subject:(Marine sponges)

1. Chairman, K. Biopotentials of secondary metabolites isolated from the selected marine sponges;.

Degree: 2015, Manonmaniam Sundaranar University

URL: http://shodhganga.inflibnet.ac.in/handle/10603/38405

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The largest groups of marine invertebrates as a source of secondary metabolites are the sponges The structurally diverse varieties of metabolites have high therapeutic potential… (more)

Subjects/Keywords: Biopotentials; isolated; marine sponges; metabolites

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Chairman, K. (2015). Biopotentials of secondary metabolites isolated from the selected marine sponges;. (Thesis). Manonmaniam Sundaranar University. Retrieved from http://shodhganga.inflibnet.ac.in/handle/10603/38405

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Chairman, K. “Biopotentials of secondary metabolites isolated from the selected marine sponges;.” 2015. Thesis, Manonmaniam Sundaranar University. Accessed January 22, 2021. http://shodhganga.inflibnet.ac.in/handle/10603/38405.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Chairman, K. “Biopotentials of secondary metabolites isolated from the selected marine sponges;.” 2015. Web. 22 Jan 2021.

Vancouver:

Chairman K. Biopotentials of secondary metabolites isolated from the selected marine sponges;. [Internet] [Thesis]. Manonmaniam Sundaranar University; 2015. [cited 2021 Jan 22]. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/38405.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Chairman K. Biopotentials of secondary metabolites isolated from the selected marine sponges;. [Thesis]. Manonmaniam Sundaranar University; 2015. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/38405

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

2. Gentric, Charline. La bioremédiation in situ des parcs conchylicoles par les éponges marines est-elle envisageable ? : Is bioremediation of shellfish farms by marine sponges possible ?.

Degree: Docteur es, Biotechnologie, 2016, Lorient

URL: http://www.theses.fr/2016LORIS399

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La préservation de la qualité des eaux marines et la lutte contre les pollutions liées à l'activité humaine sont devenues des enjeux mondiaux. De nombreux… (more)

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La préservation de la qualité des eaux marines et la lutte contre les pollutions liées à l'activité humaine sont devenues des enjeux mondiaux. De nombreux contaminants biologiques et polluants chimiques se retrouvent dans l’eau de mer, par conséquent dans les produits aquacoles. Ce contexte fait qu’aujourd’hui, les professionnels de la mer sont à la recherche de solutions pour préserver voire améliorer la qualité de leurs eaux. Au sein de notre biodiversité, les éponges marines sont des animaux capables de filtrer 10 000 fois leur volume en eau par jour et de retenir 80% des particules en suspension comme la matière organique, les minéraux, les bactéries et les virus. Par la même occasion, elles accumulent certains éléments traces métalliques comme le plomb, le cadmium ou le cuivre. En collaboration avec le Comité Régional de Conchyliculture de Bretagne Sud, le projet REMEDBIO dans lequel s’inscrit cette thèse se propose d'exploiter le potentiel de filtration des éponges marines du littoral breton. Les objectifs sont de contrôler le développement de bactéries pathogènes et de réduire la présence de polluants chimiques. L’éponge marine Hymeniacidon perlevis (Demospongiae) a été choisie comme modèle pour cette étude. Après avoir mis en évidence la faisabilité de la culture d’éponges marines sur l’estran, notre travail a montré, lors d’essais in vitro, une diminution de la contamination des huîtres par deux bactéries, Escherichia coli et Vibrio aestuarianus, et par le plomb, un élément trace métallique, en présence d’éponges. La dernière phase de ce travail a consisté à valoriser les résultats obtenus. Le projet d’entreprise LECOMER a débuté par le concours START’UBS (lauréat) proposé par l’Université de Bretagne Sud en 2014. Par la suite, LECOMER a été élu lauréat des Trophées de l’Innovation du Morbihan 2014.

The conservation of waters quality and the fight against pollution due to human activities havebecome global issues. Many biological contaminants and chemical pollutants are found in sea water, therefore in aquaculture products. This context fact sea professional are looking for solutions to preserve or even improve the quality of their waters. Among marine biodiversity, marine sponges filter 10 000 times their volume of water per day and retain 80 % of suspended particles such as organic matter, minerals, bacteria and viruses. In addition, sponges are therefore considered as bio-accumulators of metallic trace element such as lead, cadmium or copper. In collaboration with the Comité Régional de Conchyliculture de Bretagne Sud, REMEDBIO project proposes to exploite potential of marine sponges of the Brittany coast. One of the main priorities of this project is to reduce the impact of chemicals (heavy metals) and of biological contaminants (bacteria, viruses) on shellfish breeding. The marine sponges Hymeniacidon perlevis (Demospongiae) was chosen as the model for this study. Having demonstrated the feasibility of the culture of marine sponges on the foreshore, our work has shown, when tested in vitro, reduced…

Advisors/Committee Members: Vallée Réhel, Karine (thesis director).

Subjects/Keywords: OsHV-1; Marine sponges; Bioremediation; Lead; 660.6

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Gentric, C. (2016). La bioremédiation in situ des parcs conchylicoles par les éponges marines est-elle envisageable ? : Is bioremediation of shellfish farms by marine sponges possible ?. (Doctoral Dissertation). Lorient. Retrieved from http://www.theses.fr/2016LORIS399

Chicago Manual of Style (16^th Edition):

Gentric, Charline. “La bioremédiation in situ des parcs conchylicoles par les éponges marines est-elle envisageable ? : Is bioremediation of shellfish farms by marine sponges possible ?.” 2016. Doctoral Dissertation, Lorient. Accessed January 22, 2021. http://www.theses.fr/2016LORIS399.

MLA Handbook (7^th Edition):

Gentric, Charline. “La bioremédiation in situ des parcs conchylicoles par les éponges marines est-elle envisageable ? : Is bioremediation of shellfish farms by marine sponges possible ?.” 2016. Web. 22 Jan 2021.

Vancouver:

Gentric C. La bioremédiation in situ des parcs conchylicoles par les éponges marines est-elle envisageable ? : Is bioremediation of shellfish farms by marine sponges possible ?. [Internet] [Doctoral dissertation]. Lorient; 2016. [cited 2021 Jan 22]. Available from: http://www.theses.fr/2016LORIS399.

Council of Science Editors:

Gentric C. La bioremédiation in situ des parcs conchylicoles par les éponges marines est-elle envisageable ? : Is bioremediation of shellfish farms by marine sponges possible ?. [Doctoral Dissertation]. Lorient; 2016. Available from: http://www.theses.fr/2016LORIS399

3. Phatchareephorn Chatakul. Chemical constituents from the sponges Halichondria sp. and Aplysinopis sp.

Degree: คณะเภสัชศาสตร์ ภาควิชาเทคโนโลยีเภสัชกรรม, 2010, Prince of Songkla University

URL: http://kb.psu.ac.th/psukb/handle/2010/8870

Subjects/Keywords: Sponges; Marine pharmacology

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APA (6^th Edition):

Chatakul, P. (2010). Chemical constituents from the sponges Halichondria sp. and Aplysinopis sp. (Thesis). Prince of Songkla University. Retrieved from http://kb.psu.ac.th/psukb/handle/2010/8870

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Chatakul, Phatchareephorn. “Chemical constituents from the sponges Halichondria sp. and Aplysinopis sp. ” 2010. Thesis, Prince of Songkla University. Accessed January 22, 2021. http://kb.psu.ac.th/psukb/handle/2010/8870.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Chatakul, Phatchareephorn. “Chemical constituents from the sponges Halichondria sp. and Aplysinopis sp. ” 2010. Web. 22 Jan 2021.

Vancouver:

Chatakul P. Chemical constituents from the sponges Halichondria sp. and Aplysinopis sp. [Internet] [Thesis]. Prince of Songkla University; 2010. [cited 2021 Jan 22]. Available from: http://kb.psu.ac.th/psukb/handle/2010/8870.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Chatakul P. Chemical constituents from the sponges Halichondria sp. and Aplysinopis sp. [Thesis]. Prince of Songkla University; 2010. Available from: http://kb.psu.ac.th/psukb/handle/2010/8870

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of the Western Cape

4. Matobole, Relebohile Matthew. Matrix comparison of isolation conditions for secondary metabolite producing marine sponge associated bacteria .

Degree: 2015, University of the Western Cape

URL: http://hdl.handle.net/11394/4754

► The discovery of novel secondary metabolites has declined significantly in recent years whereas there is a rise in the number of multi-drug resistant pathogens and… (more)

▼ The discovery of novel secondary metabolites has declined significantly in recent years whereas there is a rise in the number of multi-drug resistant pathogens and other types of diseases. The decline in natural product discovery was due to high rediscovery of already known compounds and the costs in developing natural products. As a result pharmaceutical companies lost interest in investing in natural product discovery. However, there is a renewed interest in marine sponge associated microorganisms as a rich and untapped source of secondary metabolites. The objective of this study was to design a matrix to investigate the extent to which the One Strain-Many Compounds (OSMAC) approach applies to a collection of marine sponge isolates harvested from two South African marine sponge samples. Terminal restriction fragment length polymorphisms (T-RFLP) analysis was used to investigate and ascertain the two marine sponges which hosted the highest microbial diversities to be used for further culture-dependent studies. The culture-dependent studies, using 33 media which included liquid enrichment, heat treatments and antibiotic treatments, resulted in 400 sponge isolates from the two marine sponges Isodictya compressa and Higginsia bidentifera. Using antibacterial overlay assays, 31 dereplicated isolates showed antibacterial activity. Bioactivities were also exhibited against E. coli 1699 which is genetically engineered for resistance against 52 antibiotics which implies that some of the bioactive compounds could be novel. The 16S rRNA gene sequences revealed that the microbial phyla isolated from the marine sponges belonged to Actinobacteria, Firmicutes and Proteobacteria (Alphaproteobacteria and Gammaproteobacteria).Thirty isolates were selected for an OSMAC-based matrix study, 17 of which showed noantibacterial activities in preliminary screening. The application of the OSMAC approach using co-culture and 36 culture conditions resulted in 6 isolates showing antibacterial activities, three of which did not show activities in preliminary screening. One of these, a Bacillus pumilus isolated from I. compressa displayed antibacterial activity against 5 indicator strains whereas in preliminary screening it had not shown activity. The results show that marine sponges can host novel microbial species which may produce novel bioactive compounds. The results also confirm that traditional methods employing a single culture condition restricts the expression of some biosynthetic pathways of microorganisms and as a result many metabolites have yet to be identified. Advisors/Committee Members: Tuffin, Marla (advisor).

Subjects/Keywords: Secondary metabolites; Marine sponges; Microorganisms; OSMAC

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Matobole, R. M. (2015). Matrix comparison of isolation conditions for secondary metabolite producing marine sponge associated bacteria . (Thesis). University of the Western Cape. Retrieved from http://hdl.handle.net/11394/4754

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Matobole, Relebohile Matthew. “Matrix comparison of isolation conditions for secondary metabolite producing marine sponge associated bacteria .” 2015. Thesis, University of the Western Cape. Accessed January 22, 2021. http://hdl.handle.net/11394/4754.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Matobole, Relebohile Matthew. “Matrix comparison of isolation conditions for secondary metabolite producing marine sponge associated bacteria .” 2015. Web. 22 Jan 2021.

Vancouver:

Matobole RM. Matrix comparison of isolation conditions for secondary metabolite producing marine sponge associated bacteria . [Internet] [Thesis]. University of the Western Cape; 2015. [cited 2021 Jan 22]. Available from: http://hdl.handle.net/11394/4754.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Matobole RM. Matrix comparison of isolation conditions for secondary metabolite producing marine sponge associated bacteria . [Thesis]. University of the Western Cape; 2015. Available from: http://hdl.handle.net/11394/4754

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

5. Lira, Simone Possedente de. \"Metabólitos secundários biologicamente ativos isolados de esponjas marinhas e do fungo Beauveria felina de origem marinha\".

Degree: PhD, Química Analítica, 2007, University of São Paulo

URL: http://www.teses.usp.br/teses/disponiveis/75/75132/tde-05062007-112443/ ;

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Neste trabalho descreve-se o estudo química dos extratos de quatro esponjas e dois fungos de origem marinha oriundos da costa do Brasil. Os extratos de… (more)

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Neste trabalho descreve-se o estudo química dos extratos de quatro esponjas e dois fungos de origem marinha oriundos da costa do Brasil. Os extratos de três esponjas (Petromica ciocalyptoides, Topsentia ophiraphidites e Callyspongia sp.) apresentaram atividade inibitória à enzima adenosina fosforribosil transferase de Leishmania tarentolae. A partir desses extratos foram isolados 4 compostos. O trissulafato de halistanol, isolado das esponjas P. ciocalyptoides e T. ophiraphidites, e o ilhabelanol, ilhabreno e isoakaterpina, isolados da esponja Callyspongia sp. A partir do extrato bruto da esponja Axinella cf corrugata foram isolados dois derivados cumarínicos, provavelmente artefatos de isolamento do ácido 4-esculetínico, o qual é inédito como produto natural. O extrato bruto da esponja Axinella cf. corrugata apresentou atividade citotóxica, mas os compostos puros não apresentaram esta atividade. Os dois compostos puros foram testados ainda quanto sua atividade contra o vírus da SARS, na qual o éster etílico do ácido 4-esculetínico se apresentou ativo. A partir de dois extratos oriundos do fungo Beauveria felina, isolado da alga marinha Caulerpa sp, foram isoladas 17 frações puras que após diversas análises foram agrupadas em seis compostos conhecidos na literatura: a (Phe3, N-Val5) destruxina B, a cloroidrina da destruxina E, a roseotoxina B, a roseocardina, a isariina e a isariina B. Além disso, foram isolados dois compostos inéditos, a pseudodestruxina C e a cloloidrina Beta-Me-Pro da destruxina E. Os extratos brutos de Beauveria felina apresentaram atividades em bioensaios de atividade antituberculose e de citotoxicidade em linhagem de células de câncer. Os compostos puros avaliados no bioensaio antituberculose não foram ativos. Somente o composto roseotoxina B apresentou atividade citotóxica in vitro para quatro linhagens de células: mama, cólon, sistema nervoso e leucemia.

In this work we report the chemical investigation of bioactive crude extracts obtained from four sponges and two fungal strains of marine origin. The crude extracts of three sponges species (Petromica ciocalyptoides, Topsentia ophiraphidites and Callyspongia sp.) displayed inhibitory activity towards the enzyme adenine fosforribosyl transferase of Leishmania tarentolae (L-APRT). Four compounds have been isolated from these extracts: the known halistanol sulfate was isolated of sponges P. ciocalyptoides and T. ophiraphidites, while the novel ilhabelanol, ilhabrene and isoakaterpin have been isolated from the sponge Callyspongia sp. All compounds exhibited inhibition of L-APRT at micro M concentrations. Two coumarin derivatives have been isolated from the crude extract of the sponge Axinella cf. corrugata, probably as artifacts of isolation: esculetin-4-carboxylic acid methyl ester and esculetin-4-carboxylic acid ethyl ester. While the crude extract of the sponge Axinella cf. corrugata presented cytotoxic activity, the pure compounds were inactive in these assays. The esculetin-4-carboxylic acid ethyl ester was found to be an in vitro…

Advisors/Committee Members: Berlinck, Roberto Gomes de Souza.

Subjects/Keywords: cioclodepsipeptideos; cyclodepsipeptides; esponjas marinhas; fungo marinho; marine fungi; marine sponges

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Lira, S. P. d. (2007). \"Metabólitos secundários biologicamente ativos isolados de esponjas marinhas e do fungo Beauveria felina de origem marinha\". (Doctoral Dissertation). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/75/75132/tde-05062007-112443/ ;

Chicago Manual of Style (16^th Edition):

Lira, Simone Possedente de. “\"Metabólitos secundários biologicamente ativos isolados de esponjas marinhas e do fungo Beauveria felina de origem marinha\".” 2007. Doctoral Dissertation, University of São Paulo. Accessed January 22, 2021. http://www.teses.usp.br/teses/disponiveis/75/75132/tde-05062007-112443/ ;.

MLA Handbook (7^th Edition):

Lira, Simone Possedente de. “\"Metabólitos secundários biologicamente ativos isolados de esponjas marinhas e do fungo Beauveria felina de origem marinha\".” 2007. Web. 22 Jan 2021.

Vancouver:

Lira SPd. \"Metabólitos secundários biologicamente ativos isolados de esponjas marinhas e do fungo Beauveria felina de origem marinha\". [Internet] [Doctoral dissertation]. University of São Paulo; 2007. [cited 2021 Jan 22]. Available from: http://www.teses.usp.br/teses/disponiveis/75/75132/tde-05062007-112443/ ;.

Council of Science Editors:

Lira SPd. \"Metabólitos secundários biologicamente ativos isolados de esponjas marinhas e do fungo Beauveria felina de origem marinha\". [Doctoral Dissertation]. University of São Paulo; 2007. Available from: http://www.teses.usp.br/teses/disponiveis/75/75132/tde-05062007-112443/ ;

NSYSU

6. Lin, Yu-chun. The sponge assemblage and sponge-associated microbial composition at the seawater aquafarm in southern Taiwan.

Degree: Master, Department of Oceanography, 2016, NSYSU

URL: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0803116-090136

► The aim of this study was to investigate the sponge species diversity and sponge-associated microbial composition at a seawater aquafarm in southern Taiwan. During the… (more)

Subjects/Keywords: marine sponges; aquaculture; bacteria community; next generation sequencing; 16S rRNA

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Lin, Y. (2016). The sponge assemblage and sponge-associated microbial composition at the seawater aquafarm in southern Taiwan. (Thesis). NSYSU. Retrieved from http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0803116-090136

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Lin, Yu-chun. “The sponge assemblage and sponge-associated microbial composition at the seawater aquafarm in southern Taiwan.” 2016. Thesis, NSYSU. Accessed January 22, 2021. http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0803116-090136.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Lin, Yu-chun. “The sponge assemblage and sponge-associated microbial composition at the seawater aquafarm in southern Taiwan.” 2016. Web. 22 Jan 2021.

Vancouver:

Lin Y. The sponge assemblage and sponge-associated microbial composition at the seawater aquafarm in southern Taiwan. [Internet] [Thesis]. NSYSU; 2016. [cited 2021 Jan 22]. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0803116-090136.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Lin Y. The sponge assemblage and sponge-associated microbial composition at the seawater aquafarm in southern Taiwan. [Thesis]. NSYSU; 2016. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0803116-090136

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Utah

7. James, Robyn D. Studies of the biological activity of naamidine A;.

Degree: MS;, Medicinal Chemistry;, 2002, University of Utah

URL: http://content.lib.utah.edu/cdm/singleitem/collection/etd1/id/631/rec/1260

► Malignant cells can occur due to deregulation of growth factor cascades. The binding of epidermal growth factor (EGF) to its receptor culminates in the activation… (more)

▼ Malignant cells can occur due to deregulation of growth factor cascades. The binding of epidermal growth factor (EGF) to its receptor culminates in the activation of the MAP kinase pathway. This pathway has been identified as a vital link between membrane-bound Ras and nuclear events and therefore has great pharmacological potential as a target of chemotherapeutic drugs. Naamidine A is a dibenzylated 2-aminoimidazole alkaloid from the calcareous sponge Leucetta chagosensis which was reported to exhibit potent inhibition of EGF-stimulated DNA synthesis in high-throughput screens. Proliferation inhibition data collected in a cell line transfected with the EGF receptor (EGFR) gene showed modest cytotoxicity, and preliminary in vivo data demonstrated promising squamous cell carcinoma growth inhibition. Studies were undertaken to elucidate the molecular target(s) of naamidine A and to further investigate the mechanism of action. Naamidine A showed a significant effect on the mitogenic response by completely halting DNA synthesis in A-431 cells after 30 h. Also, cells examined in this time point were shown to be arrested in the G1 phase of the cell cycle. Treatment with naamidine A also produced charges in the phosphorylation states of the extracellular signal-regulated kinases (ERKs). These enzymes propagate the activation of several proteins, which can trigger proliferation, differentiation, or cell death. The hypothesis of this thesis in that ERK1 and ERK2 are the primary cellular targets of naamidine A in A-431 cells. In vitro and in-gel kinase experiments demonstrated that ERK1 is a primary molecular target for naamidine A. In-gel data, western blotting, and notable sequence similarity to ERK1 demonstrate that ERk2 is also a primary target of naamidine A. Treatment with naamidine A strongly induces the phosphotransferase activity of the ERK enzymes in A-431 cells. Naamidine A is the first known small molecular to cause this effect on the ERK kinases. This type of robust ERK signal, previously only achieved by the transfection of activated Raf of MEK, has been shown to induce and sustain increased levels of p21[CIP1] in various cell lines in the G1 phase of the cell cycle. The increase levels of p21[CIP1] bind to and inhibit cdk2, which cannot complex with cyclin E. causing cells to arrest in late G1.

Subjects/Keywords: Marine Pharmacology; Cancer; Sponges; Physiology

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

James, R. D. (2002). Studies of the biological activity of naamidine A;. (Masters Thesis). University of Utah. Retrieved from http://content.lib.utah.edu/cdm/singleitem/collection/etd1/id/631/rec/1260

Chicago Manual of Style (16^th Edition):

James, Robyn D. “Studies of the biological activity of naamidine A;.” 2002. Masters Thesis, University of Utah. Accessed January 22, 2021. http://content.lib.utah.edu/cdm/singleitem/collection/etd1/id/631/rec/1260.

MLA Handbook (7^th Edition):

James, Robyn D. “Studies of the biological activity of naamidine A;.” 2002. Web. 22 Jan 2021.

Vancouver:

James RD. Studies of the biological activity of naamidine A;. [Internet] [Masters thesis]. University of Utah; 2002. [cited 2021 Jan 22]. Available from: http://content.lib.utah.edu/cdm/singleitem/collection/etd1/id/631/rec/1260.

Council of Science Editors:

James RD. Studies of the biological activity of naamidine A;. [Masters Thesis]. University of Utah; 2002. Available from: http://content.lib.utah.edu/cdm/singleitem/collection/etd1/id/631/rec/1260

Florida Atlantic University

8. Vansach, Tifanie. Chemical Studies of Caribbean Marine Organisms.

Degree: 2019, Florida Atlantic University

URL: http://fau.digital.flvc.org/islandora/object/fau:41415

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The projects described in this dissertation concentrated on investigating Caribbean species for qualitative and quantitative chemical differences. Chapter one includes a brief update on the… (more)

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The projects described in this dissertation concentrated on investigating Caribbean species for qualitative and quantitative chemical differences. Chapter one includes a brief update on the status of natural products as drugs, a discussion of the biodiversity of Caribbean marine organisms as well as a discussion about the chemistry of algae and sponges. In chapter two, an experiment to test for possible effects of warmer, more acidic water and how that will impact coral reef organisms was conducted. Six common Caribbean coral reef sponge species were grown in seawater for 24 days ranging from values experienced at summer-maxima (temperature = 28 ºC; pH = 8.1) to those predicted for the year 2100 (T = 31 ºC; pH = 7.8). For each species, attachment rates, growth, and survival were similar between temperature and pH levels. Only two metabolite concentrations varied significantly between treatments but were similar to baseline levels. In chapter three, a chemical survey of Florida Keys algae was performed using MeOH extraction and HP-20 SPE with varying Me2CO:H2O solutions. 1H NMR spectra were collected for each fraction and analyzed for interesting signals. A Laurencia sp. was extracted and found to contain the known compound isodactylyne (61) with the structure determined using spectroscopic analyses. In chapter four, a Laurencia obtusa specimen was investigated to determine the compound causing oxygenated signals between 4.50 – 4.80 ppm in the 1H NMR spectra observed in chapter three. A large scale extraction and fractionation was performed and the compound was determined to be 1-O-palmitoyl-2-O-myristoyl-3-O-(6-sulfo-α- D-quinovo-pyranosyl)-glycerol (63). In chapter five, the isolation and structural elucidation of a new compound, furocaespitanenone (64) and two known compounds (10R)- and (10S)-10-O-methylfurocaespitanelactol 65 and 66, from a Laurencia sp. collected off of the Florida Keys using MeOH extraction and HP-20 column chromatography is described. A potential biosynthesis of 64 from furocaepsitane (68) is proposed.

2019

Degree granted: Dissertation (Ph.D.) – Florida Atlantic University, 2019.

Collection: FAU

Advisors/Committee Members: West, Lyndon M. (Thesis advisor), Florida Atlantic University (Degree grantor), Charles E. Schmidt College of Science, Department of Chemistry and Biochemistry.

Subjects/Keywords: Marine organisms; Caribbean; Algae – chemistry; Sponges – Caribbean Sea; Chemistry

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Vansach, T. (2019). Chemical Studies of Caribbean Marine Organisms. (Thesis). Florida Atlantic University. Retrieved from http://fau.digital.flvc.org/islandora/object/fau:41415

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Vansach, Tifanie. “Chemical Studies of Caribbean Marine Organisms.” 2019. Thesis, Florida Atlantic University. Accessed January 22, 2021. http://fau.digital.flvc.org/islandora/object/fau:41415.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Vansach, Tifanie. “Chemical Studies of Caribbean Marine Organisms.” 2019. Web. 22 Jan 2021.

Vancouver:

Vansach T. Chemical Studies of Caribbean Marine Organisms. [Internet] [Thesis]. Florida Atlantic University; 2019. [cited 2021 Jan 22]. Available from: http://fau.digital.flvc.org/islandora/object/fau:41415.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Vansach T. Chemical Studies of Caribbean Marine Organisms. [Thesis]. Florida Atlantic University; 2019. Available from: http://fau.digital.flvc.org/islandora/object/fau:41415

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Montana State University

9. Barnekow, David Ernest. Absolute configuration of biologically active marine natural products.

Degree: PhD, College of Letters & Science, 1989, Montana State University

URL: https://scholarworks.montana.edu/xmlui/handle/1/7082

Subjects/Keywords: Natural products.; Sponges.; Marine biology.

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Barnekow, D. E. (1989). Absolute configuration of biologically active marine natural products. (Doctoral Dissertation). Montana State University. Retrieved from https://scholarworks.montana.edu/xmlui/handle/1/7082

Chicago Manual of Style (16^th Edition):

Barnekow, David Ernest. “Absolute configuration of biologically active marine natural products.” 1989. Doctoral Dissertation, Montana State University. Accessed January 22, 2021. https://scholarworks.montana.edu/xmlui/handle/1/7082.

MLA Handbook (7^th Edition):

Barnekow, David Ernest. “Absolute configuration of biologically active marine natural products.” 1989. Web. 22 Jan 2021.

Vancouver:

Barnekow DE. Absolute configuration of biologically active marine natural products. [Internet] [Doctoral dissertation]. Montana State University; 1989. [cited 2021 Jan 22]. Available from: https://scholarworks.montana.edu/xmlui/handle/1/7082.

Council of Science Editors:

Barnekow DE. Absolute configuration of biologically active marine natural products. [Doctoral Dissertation]. Montana State University; 1989. Available from: https://scholarworks.montana.edu/xmlui/handle/1/7082

University of Cambridge

10. Wren, Stephen P. Studies towards the total synthesis of the marine-derived immunosuppressant discodermolide.

Degree: PhD, 1995, University of Cambridge

URL: https://doi.org/10.17863/CAM.19006 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.390243

Subjects/Keywords: 547; Natural products; Marine sponges

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APA (6^th Edition):

Wren, S. P. (1995). Studies towards the total synthesis of the marine-derived immunosuppressant discodermolide. (Doctoral Dissertation). University of Cambridge. Retrieved from https://doi.org/10.17863/CAM.19006 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.390243

Chicago Manual of Style (16^th Edition):

Wren, Stephen P. “Studies towards the total synthesis of the marine-derived immunosuppressant discodermolide.” 1995. Doctoral Dissertation, University of Cambridge. Accessed January 22, 2021. https://doi.org/10.17863/CAM.19006 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.390243.

MLA Handbook (7^th Edition):

Wren, Stephen P. “Studies towards the total synthesis of the marine-derived immunosuppressant discodermolide.” 1995. Web. 22 Jan 2021.

Vancouver:

Wren SP. Studies towards the total synthesis of the marine-derived immunosuppressant discodermolide. [Internet] [Doctoral dissertation]. University of Cambridge; 1995. [cited 2021 Jan 22]. Available from: https://doi.org/10.17863/CAM.19006 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.390243.

Council of Science Editors:

Wren SP. Studies towards the total synthesis of the marine-derived immunosuppressant discodermolide. [Doctoral Dissertation]. University of Cambridge; 1995. Available from: https://doi.org/10.17863/CAM.19006 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.390243

University of the Western Cape

11. Lerata, Mookho Sylvia. Discovery of cytotoxic natural products from South African marine sponges .

Degree: 2018, University of the Western Cape

URL: http://hdl.handle.net/11394/6447

► Cancer is a major health problem worldwide and killing millions of people each year. The use of natural products as chemotherapeutic agents is well established,… (more)

Subjects/Keywords: Cancer; marine sponges; Ircinia sp.; Latrunculid sp. Pyrroloiminoquinones alkaloids; furanosesterterpenes; cytotoxicity; marine natural product libraries.

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APA (6^th Edition):

Lerata, M. S. (2018). Discovery of cytotoxic natural products from South African marine sponges . (Thesis). University of the Western Cape. Retrieved from http://hdl.handle.net/11394/6447

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Lerata, Mookho Sylvia. “Discovery of cytotoxic natural products from South African marine sponges .” 2018. Thesis, University of the Western Cape. Accessed January 22, 2021. http://hdl.handle.net/11394/6447.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Lerata, Mookho Sylvia. “Discovery of cytotoxic natural products from South African marine sponges .” 2018. Web. 22 Jan 2021.

Vancouver:

Lerata MS. Discovery of cytotoxic natural products from South African marine sponges . [Internet] [Thesis]. University of the Western Cape; 2018. [cited 2021 Jan 22]. Available from: http://hdl.handle.net/11394/6447.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Lerata MS. Discovery of cytotoxic natural products from South African marine sponges . [Thesis]. University of the Western Cape; 2018. Available from: http://hdl.handle.net/11394/6447

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Florida Atlantic University

12. Plunkett, Rachel. Discovery of Loxosomella vivipara (Entoprocta: Loxosomatidae) in the Marine Sponge Hippospongia cf. gossypina (Porifera: Spongiidae) in the Florida Keys.

Degree: MS, 2016, Florida Atlantic University

URL: http://purl.flvc.org/fau/fd/FA00004791 ; (URL) http://purl.flvc.org/fau/fd/FA00004791

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Summary: Populations of a marine invertebrate symbiont were found on the outer surface and internal spaces of a keratose sponge from a shallow bay in… (more)

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Summary: Populations of a marine invertebrate symbiont were found on the outer surface and internal spaces of a keratose sponge from a shallow bay in the Florida Keys in May 2014. A total of 24 specimens of the seagrass and reef-dwelling sponge were collected between May 2014 and August 2015 to provide material to identify both host and symbiont, and elucidate information on the nature of the association. Based on a morphological analysis via light microscopy, histology, and scanning electron microscopy (SEM), and 99% similarity in aligned partial sequences from 28S and 18S nuclear ribosomal genes (rDNA), the symbiont was identified as the solitary entoproct Loxosomella vivipara Nielsen, 1966 (Entoprocta: Loxosomatidae). A partial sequence from the Internal Transcribed Spacer Region 2 (ITS2) of L. vivipara was registered to GenBank for the first time. The identity of the host sponge, based on a morphological investigation, is resolved as “velvet sponge” Hippospongia cf. gossypina Duchassing and Michelotti, 1864 (Demospongiae: Spongiidae). This is the first report of an entoproct commensal from Hippospongia cf. gossypina, a sponge that formerly had great commercial value when it was abundant throughout the Bahamas, Florida Keys and Gulf of Mexico. Other common sponge species at the study site were collected to investigate the host specificity of L. vivipara. Evidence that L. vivipara favorably selects the sponges Hippospongia cf. gossypina and Chondrilla nucula over other potential host sponges at the study site is provided. Commensalism is the most plausible justification for this relationship: L. vivipara is dependent on sponges for protection and food particles, while the sponges are unaffected by its presence. Further evidence of host-specific inquilinism is provided for L. vivipara associated with Hippospongia cf. gossypina, but not for L. vivipara associated with C. nucula. An inquilinistic association between an entoproct and sponge is a rare discovery only mentioned in one previous study. Sponge aquiferous qualities such as aperture and canal size, canal and choanocyte chamber arrangement, seawater pumping rate, and food particle size selection are likely factors that inhibit or enable inquilinism in sponge-entoproct associations – a potential topic for future researc

2016

Degree granted:

Collection: FAU

Advisors/Committee Members: Pomponi, Shirley A. (Thesis advisor), Florida Atlantic University (Degree grantor), Charles E. Schmidt College of Science, Department of Biological Sciences.

Subjects/Keywords: Marine invertebrates – Florida.; Sponges – Habitat – Florida.; Marine resources – Florida – Management.; Aquatic biology.; Entoprocta – Classification.

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Plunkett, R. (2016). Discovery of Loxosomella vivipara (Entoprocta: Loxosomatidae) in the Marine Sponge Hippospongia cf. gossypina (Porifera: Spongiidae) in the Florida Keys. (Masters Thesis). Florida Atlantic University. Retrieved from http://purl.flvc.org/fau/fd/FA00004791 ; (URL) http://purl.flvc.org/fau/fd/FA00004791

Chicago Manual of Style (16^th Edition):

Plunkett, Rachel. “Discovery of Loxosomella vivipara (Entoprocta: Loxosomatidae) in the Marine Sponge Hippospongia cf. gossypina (Porifera: Spongiidae) in the Florida Keys.” 2016. Masters Thesis, Florida Atlantic University. Accessed January 22, 2021. http://purl.flvc.org/fau/fd/FA00004791 ; (URL) http://purl.flvc.org/fau/fd/FA00004791.

MLA Handbook (7^th Edition):

Plunkett, Rachel. “Discovery of Loxosomella vivipara (Entoprocta: Loxosomatidae) in the Marine Sponge Hippospongia cf. gossypina (Porifera: Spongiidae) in the Florida Keys.” 2016. Web. 22 Jan 2021.

Vancouver:

Plunkett R. Discovery of Loxosomella vivipara (Entoprocta: Loxosomatidae) in the Marine Sponge Hippospongia cf. gossypina (Porifera: Spongiidae) in the Florida Keys. [Internet] [Masters thesis]. Florida Atlantic University; 2016. [cited 2021 Jan 22]. Available from: http://purl.flvc.org/fau/fd/FA00004791 ; (URL) http://purl.flvc.org/fau/fd/FA00004791.

Council of Science Editors:

Plunkett R. Discovery of Loxosomella vivipara (Entoprocta: Loxosomatidae) in the Marine Sponge Hippospongia cf. gossypina (Porifera: Spongiidae) in the Florida Keys. [Masters Thesis]. Florida Atlantic University; 2016. Available from: http://purl.flvc.org/fau/fd/FA00004791 ; (URL) http://purl.flvc.org/fau/fd/FA00004791

NSYSU

13. Chou , Ya-lan. Study of the Biogenic Silica Contents and Its Incorporation by Keratose Sponges.

Degree: PhD, Department of Oceanography, 2014, NSYSU

URL: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0808114-201126

► Organisms that have Biogenic silica (BSi) skeletons include diatoms, silicoflagellates, radiolarians and sponges. BSi in marine sediments is an important indicator of siliceous organism distributions… (more)

▼ Organisms that have Biogenic silica (BSi) skeletons include diatoms, silicoflagellates, radiolarians and sponges. BSi in marine sediments is an important indicator of siliceous organism distributions and paleoproductivities, but the estimation were based on diatom frustule amounts. The sponges and radiolarians were excluded from the marine siliceous biogeochemical cycle estimation in the past. However, sponges had became a role in the cycle in recent years. The siliceous demosponges and the glass sponge reefs were suggested as a sink in local silica cycles. While the glass sponges and demosponges have been investigated, more results to support the importance of sponges in silica cycle was expected. This study will focus on the sponge spicules in sediments and the keratose sponges (Order: Dictyoceratida). There are three main parts in this study: 1. The Spatial distribution of spicules in sediments around Taiwan and the Sunda Shelf. 2. An efficient wet-chemical method to determine biogenic silica content in sponges. 3. Distribution of foreign particles in the bath sponge, Spongia sp.. Thirty-one surface sediment samples were collected in South China Sea. Only sponge spicules were found in the depth from intertidal to depths of 1128 m, and the abundance of sponge spicules correlated positively and negatively with water depth and sediment grain size when coral reef sites were excluded, respectively. The low spicule abundance in shallow waters may have resulted by current conditions and the dilution effect through riverine input of terrestrial sediment. The highest spicule amount were found in coral reef sites, especially Site DBS, where the spicule number reached 7910 spicule nâ¢ g-1 sediment and 2293 spicule nâ¢ g-1 sediment in Site SK in Penghu area. The correlation of spicule in sediments and sponge biomass indicated the sponge biomass was not significantly related to spicules in sediments in Penghu intertidals, which may be influenced by local water currents and unrecorded sponge species. However, the large amount of keratose sponges could also increase the spicule amount in sediments by preserving those particles in sediment upper layers. To measure the BSi in sponges, the wet-chemical method was employed to understand if this method is efficient for determing the BSi amounts in sponges. The wet-chemical method, that was used to measure the BSi in marine sediments studies, included alkaline solution digestion and molybdosilicate yellow determination as two steps. In addition to the wet-chemical method tests, the BSi amounts in five sponge species were compared after the methodology was fixed. The results indicated stable digestion of sponge BSi can be obtained by 2M KOH with 8.5-9 hours digestion time. As for molybdosilicate yellow method, the suppressive regent was suggested to remove from experiment. Samples can obtain the stable yellow color in 50Â°C water bath for 1 hour. The obtained BSi is about 80-90% of the original particle weight. Among the five sponge species, bath sponge Spongia sp. was with the lowest… Advisors/Committee Members: Li-Lian Liu (committee member), Hin-Kiu Mok (chair), Hsing-Juh Lin (chair), Meng-Hsien Chen (chair), Chang-Feng Dai (chair).

Subjects/Keywords: bath sponge Spongia sp.; marine sediment; sponge biomass; keratose sponges; biogenic silica; wet-chemical method

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Chou , Y. (2014). Study of the Biogenic Silica Contents and Its Incorporation by Keratose Sponges. (Doctoral Dissertation). NSYSU. Retrieved from http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0808114-201126

Chicago Manual of Style (16^th Edition):

Chou , Ya-lan. “Study of the Biogenic Silica Contents and Its Incorporation by Keratose Sponges.” 2014. Doctoral Dissertation, NSYSU. Accessed January 22, 2021. http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0808114-201126.

MLA Handbook (7^th Edition):

Chou , Ya-lan. “Study of the Biogenic Silica Contents and Its Incorporation by Keratose Sponges.” 2014. Web. 22 Jan 2021.

Vancouver:

Chou Y. Study of the Biogenic Silica Contents and Its Incorporation by Keratose Sponges. [Internet] [Doctoral dissertation]. NSYSU; 2014. [cited 2021 Jan 22]. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0808114-201126.

Council of Science Editors:

Chou Y. Study of the Biogenic Silica Contents and Its Incorporation by Keratose Sponges. [Doctoral Dissertation]. NSYSU; 2014. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0808114-201126

14. Chaves-Fonnegra, Andia. Increase of Excavating Sponges on Caribbean Coral Reefs: Reproduction, Dispersal, and Coral Deterioration.

Degree: 2014, Nova Southeastern University

URL: http://nsuworks.nova.edu/occ_stuetd/5

► Coral reefs ecosystems are deteriorating and facing dramatic changes. These changes suggest a shift in dominance from corals to other benthic organisms. Particularly in the… (more)

▼ Coral reefs ecosystems are deteriorating and facing dramatic changes. These changes suggest a shift in dominance from corals to other benthic organisms. Particularly in the Caribbean Sea, with corals dying, sponges have become the leading habitat-forming benthic animals. However, little is known about what life-history traits allow organisms to proliferate in a marine system that is undergoing change. Thus, the objective of this dissertation was to try to understand the current increase of encrusting excavating sponges on deteriorating Caribbean coral reefs through the study of reproduction, recruitment and dispersal potential of the widely distributed and currently expanding species, Cliona delitrix. Different methodological approaches were used, such as histology, electron microscopy, quantification of sponges in the field, genetics, and mathematical modeling. Results are presented in four different chapters. It was found that Cliona delitrix has an extended reproductive cycle in Florida, USA, from April - May to around November - December depending on a >25°C sea-water temperature threshold. C. delitrix gametogenesis is asynchronous and it has multiple spawning events. C. delitrix is recruiting abundantly on Caribbean coral reefs, preferentially on recent coral mortality than on old coral mortality. The increase in C. delitrix and other excavating sponges can be explained by the repeated spawning and by the coincidence in time and space of larval production with the availability of new dead coral, which tend to overlap during the warmest months of the year. Eggs or larvae of C. delitrix appear to survive enough to be transported by currents over larger distances. It was found that dispersal ranges for Cliona delitrix may reach as far as ~315 km in the Florida reef track, and over ~971 km in the South Caribbean Sea, between Belize and Panama. Thus, reproduction, dispersal, and recruitment patterns of C. delitrix along with oceanographic currents, and eddies that form at different periods of time, are sustaining the spread of this sponge on coral reefs. According to mathematical models carried out, C. delitrix increase on reefs fluctuates depending of coral mortality events and available space on old dead coral (colonized by algae and other invertebrates). However, under temperature anomalies, these sponges will 2 tend to increase and take over the reef system only if heat stress and coral mortality is moderate. Under massive mortality events both corals and sponges will tend to decline, although sponges at a slower rate than corals. In general, coral excavating sponges have been favored by coral mortality, especially during past few decades. However as bioeroders, their success is also limited by the success of calcifying corals. In a reef management context and based on this dissertation’s findings, it is suggested that excavating sponges, and especially Cliona delitrix, should be more formally included in reef monitoring programs. Their increase can be used to track coral mortality events on reefs (past and…

Subjects/Keywords: Life-History Traits; Coral Reefs Death; Excavating Sponges; Climate Change; Bioindicator; Marine Biology

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APA (6^th Edition):

Chaves-Fonnegra, A. (2014). Increase of Excavating Sponges on Caribbean Coral Reefs: Reproduction, Dispersal, and Coral Deterioration. (Thesis). Nova Southeastern University. Retrieved from http://nsuworks.nova.edu/occ_stuetd/5

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Chaves-Fonnegra, Andia. “Increase of Excavating Sponges on Caribbean Coral Reefs: Reproduction, Dispersal, and Coral Deterioration.” 2014. Thesis, Nova Southeastern University. Accessed January 22, 2021. http://nsuworks.nova.edu/occ_stuetd/5.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Chaves-Fonnegra, Andia. “Increase of Excavating Sponges on Caribbean Coral Reefs: Reproduction, Dispersal, and Coral Deterioration.” 2014. Web. 22 Jan 2021.

Vancouver:

Chaves-Fonnegra A. Increase of Excavating Sponges on Caribbean Coral Reefs: Reproduction, Dispersal, and Coral Deterioration. [Internet] [Thesis]. Nova Southeastern University; 2014. [cited 2021 Jan 22]. Available from: http://nsuworks.nova.edu/occ_stuetd/5.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Chaves-Fonnegra A. Increase of Excavating Sponges on Caribbean Coral Reefs: Reproduction, Dispersal, and Coral Deterioration. [Thesis]. Nova Southeastern University; 2014. Available from: http://nsuworks.nova.edu/occ_stuetd/5

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

15. Purushottama G B. Microbial association with marine sponges available in different parts of India;.

Degree: Fisheries Microbiology, 2009, Karnataka Veterinary, Animal and Fisheries Sciences University

URL: http://shodhganga.inflibnet.ac.in/handle/10603/6990

Included

Summary p. 81-83 and Bibliography p. 84-116, Appendix included

Advisors/Committee Members: Venugopal, M N.

Subjects/Keywords: Veterinary Sciences; Fisheries Microbiology; Marine sponges

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

B, P. G. (2009). Microbial association with marine sponges available in different parts of India;. (Thesis). Karnataka Veterinary, Animal and Fisheries Sciences University. Retrieved from http://shodhganga.inflibnet.ac.in/handle/10603/6990

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

B, Purushottama G. “Microbial association with marine sponges available in different parts of India;.” 2009. Thesis, Karnataka Veterinary, Animal and Fisheries Sciences University. Accessed January 22, 2021. http://shodhganga.inflibnet.ac.in/handle/10603/6990.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

B, Purushottama G. “Microbial association with marine sponges available in different parts of India;.” 2009. Web. 22 Jan 2021.

Vancouver:

B PG. Microbial association with marine sponges available in different parts of India;. [Internet] [Thesis]. Karnataka Veterinary, Animal and Fisheries Sciences University; 2009. [cited 2021 Jan 22]. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/6990.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

B PG. Microbial association with marine sponges available in different parts of India;. [Thesis]. Karnataka Veterinary, Animal and Fisheries Sciences University; 2009. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/6990

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Wollongong

16. Zivanovic, Ana. Marine natural products isolation, screening and analogue synthesis.

Degree: Doctor of Philosophy, 2012, University of Wollongong

URL: 030401 Biologically Active Molecules, 030502 Natural Products Chemistry ; https://ro.uow.edu.au/theses/3692

► Most drugs used today demonstrate their bioactivity by acting as receptor antagonists or as enzyme inhibitors. Due to the significant role of enzymes in… (more)

▼ Most drugs used today demonstrate their bioactivity by acting as receptor antagonists or as enzyme inhibitors. Due to the significant role of enzymes in the activity of a number of disease processes, and their structural conformation that is easily accessible to inhibition by small drug like molecules, they are widely investigated as drug targets. The first step in the preparation of an enzyme inhibitor is defining the target enzyme whose function is going to be interrupted or blocked in a particular disease or infection. c-AMP Dependent protein kinase A (PKA) is an important enzyme involved in the regulation of a large number of physiological processes. As such, the inhibition of PKA has become an attractive drug target in a number of areas, in particular in immune function and for memory disorders. Interestingly, despite PKA being one of the most well characterised of all protein kinases, there are as yet no PKA inhibitors reported from marine sources. The natural environment has provided a wealth of chemically diverse, bioactive compounds that are responsible for over half of the medications currently available for a multitude of diseases. Herein, ten algal species from South East Australia assigned as Prionitis linearis, Corallina vancouveriensis, Codium fragile, Codium dimorphum, Colpomenia sinuosa, Padina sp., Phyllospora comosa, Sargassum vestitum, Sargassum sp. and Ulva lactuca were analysed. Extracts of different polarity were generated from each sample and tested for their PKA inhibitory activity, haemolytic activity and brine shrimp cytotoxicity giving novel results on bioactivity from marine algae. There are no literature data so far on the kinase inhibitory activities of extracts isolated from these algal samples and for most of the samples haemolytic data are also reported for the first time. Furthermore, the chemical (fatty acid and sterol) composition of the ten algal extracts were also analysed and compared. The bioactivity profiles of the alga samples were strongly species dependent, with no apparent correlation between PKA inhibition, haemolysis and/or brine shrimp lethality. In general, the non-polar fractions isolated from all alga samples were found to give potent biological results and displayed more activity, in particular greater PKA inhibitory activity, compared with the polar fractions. The biological activity is reflected in the different algal divisions, with the order of PKA inhibitory activity identified as follows: brown seaweeds > red seaweeds > green seaweeds.…

Subjects/Keywords: algae; marine natural products; deep-sea sponges; isatin; c-AMP dependant protein kinase

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Zivanovic, A. (2012). Marine natural products isolation, screening and analogue synthesis. (Doctoral Dissertation). University of Wollongong. Retrieved from 030401 Biologically Active Molecules, 030502 Natural Products Chemistry ; https://ro.uow.edu.au/theses/3692

Chicago Manual of Style (16^th Edition):

Zivanovic, Ana. “Marine natural products isolation, screening and analogue synthesis.” 2012. Doctoral Dissertation, University of Wollongong. Accessed January 22, 2021. 030401 Biologically Active Molecules, 030502 Natural Products Chemistry ; https://ro.uow.edu.au/theses/3692.

MLA Handbook (7^th Edition):

Zivanovic, Ana. “Marine natural products isolation, screening and analogue synthesis.” 2012. Web. 22 Jan 2021.

Vancouver:

Zivanovic A. Marine natural products isolation, screening and analogue synthesis. [Internet] [Doctoral dissertation]. University of Wollongong; 2012. [cited 2021 Jan 22]. Available from: 030401 Biologically Active Molecules, 030502 Natural Products Chemistry ; https://ro.uow.edu.au/theses/3692.

Council of Science Editors:

Zivanovic A. Marine natural products isolation, screening and analogue synthesis. [Doctoral Dissertation]. University of Wollongong; 2012. Available from: 030401 Biologically Active Molecules, 030502 Natural Products Chemistry ; https://ro.uow.edu.au/theses/3692

17. Maloubier, Melody. Spéciation et bioaccumulation dans un organisme modèle de U, Np et Am en milieu marin : Speciation and bioaccumulation in a model organism of U, Np and Am in the marine environment.

Degree: Docteur es, Chimie, 2015, Nice

URL: http://www.theses.fr/2015NICE4101

►

Le devenir des radionucléides naturels et anthropogéniques dans l’environnement demeure une préoccupation majeure des sociétés modernes nucléarisées. Parmi les compartiments environnementaux possiblement impactés, l’hydrosphère est… (more)

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Le devenir des radionucléides naturels et anthropogéniques dans l’environnement demeure une préoccupation majeure des sociétés modernes nucléarisées. Parmi les compartiments environnementaux possiblement impactés, l’hydrosphère est ubiquitaire et peut transporter des composés ou éléments sur de très longues distances. L’évènement récent de Fukushima a démontré que le milieu marin pouvait être également directement impacté ce qui amène à des questionnements tant scientifiques que sociétaux. De nombreuses études ont déjà montré que les radionucléides présents dans l’eau de mer peuvent être fortement accumulés par les organismes marins mais pour autant leur spéciation est inconnue. Or cette connaissance est essentielle afin de maîtriser les mécanismes de transfert entre l’hydrosphère et la biosphère et d'évaluer in fine l’impact global sur l’Homme. Dans ce travail, nous avons choisi de déterminer expérimentalement la spéciation de trois actinides dans l’eau de mer dopée : l’uranium(VI), le neptunium(V) et l’américium(III) (via l’analogue europium(III)) en couplant des calculs de spéciation avec les outils spectroscopiques dont la Spectroscopie Laser Résolue en Temps (SLRT) et la Spectroscopie d'Absorption des Rayons X (EXAFS). Puis nous avons étudié les processus d’accumulation sur l’éponge A. cavernicola, choisi ici car considérée comme un biomoniteur de pollution pour les métaux lourds. L’accumulation de l’europium(III), de l’américium(III) et de l’uranium(VI) dans A. cavernicola a donc été investiguée à l'échelle de traces et ultra traces. Pour l'europium, les techniques d'imagerie X et électronique ont permis de localiser l'élément accumulé et d'en préciser la spéciation.

The fate of natural and anthropogenic radionuclides in the environment remains a major concern in our modern nuclearized societies. Among the environmental compartments, the hydrosphere is ubiquitous and can transport compounds or elements over very long distances. The recent event of Fukushima demonstrated that the marine environment could be directly affected and this raises both scientific and societal questions. Moreover, some studies have already shown that radionuclides present in seawater can be strongly accumulated by marine organisms although their speciation is most of the time unknown. Yet this knowledge is essential to better understand the transfer mechanisms from the hydrosphere to the biosphere and to evaluate their global impact on humans. In this work, we chose to experimentally determine the speciation of three actinides in doped seawater: uranium(VI), neptunium(V) and americium(III) (and the chemical surrogate europium(III)) by coupling speciation modeling with spectroscopic tools among which Time-Resolved Laser-Induced Fluorescence (TRLIF) and X-ray Absorption Spectroscopy (XAS). Then, we have studied the accumulation process in the sponge A. cavernicola, chosen here because it is considered as a biomonitor of heavy metal pollution. The accumulation of europium(III), americium(III) and uranium(VI) in A. cavernicola were…

Advisors/Committee Members: Den Auwer, Christophe (thesis director), Moulin, Christophe (thesis director).

Subjects/Keywords: Spéciation; Radionucléides; Milieu marin; Éponge; EXAFS; SLRT; Speciation; Radionuclides; Marine environment; Sponges; EXAFS; TRLIF

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APA (6^th Edition):

Maloubier, M. (2015). Spéciation et bioaccumulation dans un organisme modèle de U, Np et Am en milieu marin : Speciation and bioaccumulation in a model organism of U, Np and Am in the marine environment. (Doctoral Dissertation). Nice. Retrieved from http://www.theses.fr/2015NICE4101

Chicago Manual of Style (16^th Edition):

Maloubier, Melody. “Spéciation et bioaccumulation dans un organisme modèle de U, Np et Am en milieu marin : Speciation and bioaccumulation in a model organism of U, Np and Am in the marine environment.” 2015. Doctoral Dissertation, Nice. Accessed January 22, 2021. http://www.theses.fr/2015NICE4101.

MLA Handbook (7^th Edition):

Maloubier, Melody. “Spéciation et bioaccumulation dans un organisme modèle de U, Np et Am en milieu marin : Speciation and bioaccumulation in a model organism of U, Np and Am in the marine environment.” 2015. Web. 22 Jan 2021.

Vancouver:

Maloubier M. Spéciation et bioaccumulation dans un organisme modèle de U, Np et Am en milieu marin : Speciation and bioaccumulation in a model organism of U, Np and Am in the marine environment. [Internet] [Doctoral dissertation]. Nice; 2015. [cited 2021 Jan 22]. Available from: http://www.theses.fr/2015NICE4101.

Council of Science Editors:

Maloubier M. Spéciation et bioaccumulation dans un organisme modèle de U, Np et Am en milieu marin : Speciation and bioaccumulation in a model organism of U, Np and Am in the marine environment. [Doctoral Dissertation]. Nice; 2015. Available from: http://www.theses.fr/2015NICE4101

18. Yang, Chen. Isolation, Phylogenetic Analysis and Antibiotic Activity Screening of Red Sea Sponge-Associated Actinobacteria.

Degree: 2013, King Abdullah University of Science and Technology

URL: http://hdl.handle.net/10754/293817

► Infectious disease has always been and will continue to be a heavy burden on human society worldwide. Terrestrial actinobacteria, notable as a source of antibiotics,… (more)

Subjects/Keywords: marine sponges; actinobacteria; antibiotic activity

…bioactive compounds. Considering that the microbial symbionts associated with marine sponges are… …abundant actinobacteria associated with marine sponges [47]. Recently, Hentschel et al… …conflicting findings can be united and improve the selectivity of actinobacteria from marine sponges… …17 Figure 2 Photographs of Red Sea sponges in situ… …previous studies [1-4], marine actinobacteria are good candidates in search for new…

11 more images…

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APA (6^th Edition):

Yang, C. (2013). Isolation, Phylogenetic Analysis and Antibiotic Activity Screening of Red Sea Sponge-Associated Actinobacteria. (Thesis). King Abdullah University of Science and Technology. Retrieved from http://hdl.handle.net/10754/293817

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Yang, Chen. “Isolation, Phylogenetic Analysis and Antibiotic Activity Screening of Red Sea Sponge-Associated Actinobacteria.” 2013. Thesis, King Abdullah University of Science and Technology. Accessed January 22, 2021. http://hdl.handle.net/10754/293817.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Yang, Chen. “Isolation, Phylogenetic Analysis and Antibiotic Activity Screening of Red Sea Sponge-Associated Actinobacteria.” 2013. Web. 22 Jan 2021.

Vancouver:

Yang C. Isolation, Phylogenetic Analysis and Antibiotic Activity Screening of Red Sea Sponge-Associated Actinobacteria. [Internet] [Thesis]. King Abdullah University of Science and Technology; 2013. [cited 2021 Jan 22]. Available from: http://hdl.handle.net/10754/293817.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Yang C. Isolation, Phylogenetic Analysis and Antibiotic Activity Screening of Red Sea Sponge-Associated Actinobacteria. [Thesis]. King Abdullah University of Science and Technology; 2013. Available from: http://hdl.handle.net/10754/293817

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

19. Firsova, Daria. Combining biological and chemical approaches in marine biodiscovery .

Degree: 2017, National University of Ireland – Galway

URL: http://hdl.handle.net/10379/6689

► Marine organisms are prolific producers of novel and structurally interesting metabolites. The identification of marine natural products contributes to many scientific areas including pharmacology, chemical… (more)

Subjects/Keywords: Marine natural products; High throughput screening; Colorectal cancer; Chemical screening; Sponges; Chemistry

11 more images…

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APA (6^th Edition):

Firsova, D. (2017). Combining biological and chemical approaches in marine biodiscovery . (Thesis). National University of Ireland – Galway. Retrieved from http://hdl.handle.net/10379/6689

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Firsova, Daria. “Combining biological and chemical approaches in marine biodiscovery .” 2017. Thesis, National University of Ireland – Galway. Accessed January 22, 2021. http://hdl.handle.net/10379/6689.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Firsova, Daria. “Combining biological and chemical approaches in marine biodiscovery .” 2017. Web. 22 Jan 2021.

Vancouver:

Firsova D. Combining biological and chemical approaches in marine biodiscovery . [Internet] [Thesis]. National University of Ireland – Galway; 2017. [cited 2021 Jan 22]. Available from: http://hdl.handle.net/10379/6689.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Firsova D. Combining biological and chemical approaches in marine biodiscovery . [Thesis]. National University of Ireland – Galway; 2017. Available from: http://hdl.handle.net/10379/6689

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Florida Atlantic University

20. Grima, Jennifer. Effects of stressors on differential gene expression and secondary metabolites by Axinella corrugata.

Degree: MS, 2013, Florida Atlantic University

URL: http://purl.flvc.org/fcla/dt/3360781

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Summary: Sponges are an important source of bioactive marine natural products, or secondary metabolites. The common Caribbean reef sponge, Axinella corrugata, produces an antitumor and… (more)

Subjects/Keywords: Axinellida; Sponges; Marine pharmacology; Adaptation (Biology); Gene expression; Genetic regulation; Stress (Physiology); Ecophysiology

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APA (6^th Edition):

Grima, J. (2013). Effects of stressors on differential gene expression and secondary metabolites by Axinella corrugata. (Masters Thesis). Florida Atlantic University. Retrieved from http://purl.flvc.org/fcla/dt/3360781

Chicago Manual of Style (16^th Edition):

Grima, Jennifer. “Effects of stressors on differential gene expression and secondary metabolites by Axinella corrugata.” 2013. Masters Thesis, Florida Atlantic University. Accessed January 22, 2021. http://purl.flvc.org/fcla/dt/3360781.

MLA Handbook (7^th Edition):

Grima, Jennifer. “Effects of stressors on differential gene expression and secondary metabolites by Axinella corrugata.” 2013. Web. 22 Jan 2021.

Vancouver:

Grima J. Effects of stressors on differential gene expression and secondary metabolites by Axinella corrugata. [Internet] [Masters thesis]. Florida Atlantic University; 2013. [cited 2021 Jan 22]. Available from: http://purl.flvc.org/fcla/dt/3360781.

Council of Science Editors:

Grima J. Effects of stressors on differential gene expression and secondary metabolites by Axinella corrugata. [Masters Thesis]. Florida Atlantic University; 2013. Available from: http://purl.flvc.org/fcla/dt/3360781

University of New South Wales

21. Taylor, Michael W. The ecology of marine sponge-associated bacteria.

Degree: Science. Biological, Earth and Environmental Sciences, 2004, University of New South Wales

URL: http://handle.unsw.edu.au/1959.4/64480 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:62148/SOURCE01?view=true

Subjects/Keywords: Marine bacteria; Sponges; Thesis Digitisation Program

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APA (6^th Edition):

Taylor, M. W. (2004). The ecology of marine sponge-associated bacteria. (Doctoral Dissertation). University of New South Wales. Retrieved from http://handle.unsw.edu.au/1959.4/64480 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:62148/SOURCE01?view=true

Chicago Manual of Style (16^th Edition):

Taylor, Michael W. “The ecology of marine sponge-associated bacteria.” 2004. Doctoral Dissertation, University of New South Wales. Accessed January 22, 2021. http://handle.unsw.edu.au/1959.4/64480 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:62148/SOURCE01?view=true.

MLA Handbook (7^th Edition):

Taylor, Michael W. “The ecology of marine sponge-associated bacteria.” 2004. Web. 22 Jan 2021.

Vancouver:

Taylor MW. The ecology of marine sponge-associated bacteria. [Internet] [Doctoral dissertation]. University of New South Wales; 2004. [cited 2021 Jan 22]. Available from: http://handle.unsw.edu.au/1959.4/64480 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:62148/SOURCE01?view=true.

Council of Science Editors:

Taylor MW. The ecology of marine sponge-associated bacteria. [Doctoral Dissertation]. University of New South Wales; 2004. Available from: http://handle.unsw.edu.au/1959.4/64480 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:62148/SOURCE01?view=true

Florida Atlantic University

22. Rueda de Leon, Rolando. An extraction optimization and determination of the absolute configuartion of clathric acid.

Degree: MS, 2012, Florida Atlantic University

URL: http://purl.flvc.org/FAU/3355874

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Summary: Current research in natural products has heavily focused on the identification of potent biologically active compounds, specifically for drug development. The project detailed in… (more)

Subjects/Keywords: Organic compounds – Analysis; Extraction (Chemistry); Natural products – Therapeutic use; Marine biotechology; Marine resources – Research; Sponges – Ecology

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Rueda de Leon, R. (2012). An extraction optimization and determination of the absolute configuartion of clathric acid. (Masters Thesis). Florida Atlantic University. Retrieved from http://purl.flvc.org/FAU/3355874

Chicago Manual of Style (16^th Edition):

Rueda de Leon, Rolando. “An extraction optimization and determination of the absolute configuartion of clathric acid.” 2012. Masters Thesis, Florida Atlantic University. Accessed January 22, 2021. http://purl.flvc.org/FAU/3355874.

MLA Handbook (7^th Edition):

Rueda de Leon, Rolando. “An extraction optimization and determination of the absolute configuartion of clathric acid.” 2012. Web. 22 Jan 2021.

Vancouver:

Rueda de Leon R. An extraction optimization and determination of the absolute configuartion of clathric acid. [Internet] [Masters thesis]. Florida Atlantic University; 2012. [cited 2021 Jan 22]. Available from: http://purl.flvc.org/FAU/3355874.

Council of Science Editors:

Rueda de Leon R. An extraction optimization and determination of the absolute configuartion of clathric acid. [Masters Thesis]. Florida Atlantic University; 2012. Available from: http://purl.flvc.org/FAU/3355874

Rhodes University

23. Walmsley, Tara Aisling. An investigation into the bacterial diversity associated with South African latrunculid sponges that produce bioactive secondary metabolites.

Degree: PhD, Faculty of Science, Biochemistry, Microbiology and Biotechnology, 2014, Rhodes University

URL: http://hdl.handle.net/10962/d1012943

► Algoa Bay Latrunculid sponges are well known for their production of cytotoxic pyrroloiminoquinones with speculation that these secondary metabolites may have a microbial origin. This… (more)

▼ Algoa Bay Latrunculid sponges are well known for their production of cytotoxic pyrroloiminoquinones with speculation that these secondary metabolites may have a microbial origin. This study describes a thorough investigation into the bacterial community associated with Tsitsikamma favus, Tsitsikamma scurra a newly described Latrunculia sp. and a yellow encrusting sponge associated with T. scurra. Molecular and chemical characterisation were used in conjunction with traditional taxonomy in identification of the sponge specimens. The 28S rRNA and COX1 analysis confirmed the traditional taxonomy with T. favus and T. scurra being very closely related. Chemical analysis revealed that T. favus and T. scurra shared the discorhabdins 2,4-debromo-3-dihydrodiscorhabdin C, 7,8-dehydro-3-dihydrodiscorhabdin C and 14-bromo-1-hydroxy-discorhabdin V in common with each other and Tsitsikamma pedunculata indicating that these pyrroloiminoquinones are common to Tsitsikamma sponges in general. The bacterial community associated with T. favus was explored using 16S rRNA molecular techniques including DGGE, clonal libraries of full length 16S rRNA genes, as well as 454 pyrosequencing. DGGE analysis revealed that the bacterial community associated with T. favus appeared to be highly conserved, which was confirmed by both the clone library and 454 pyrosequencing, with the Betaproteobacteria as the most dominant class. Further exploration into T. favus, as well as T. scurra, Latrunculia sp. and the yellow encrusting sponge indicated that the bacterial populations associated with each of these sponge species were conserved and species specific. OTU analysis to the species level revealed that T. favus and T. scurra shared an abundant Spirochaete species in common while the most abundant species in the Latrunculia sp. and the yellow encrusting sponge belonged to the class Betaproteobacteria. The exclusivity of the tsitsikammamines to T. favus precipitated attempts to culture the T. favus associated bacteria, with a focus on the dominant betaproteobacterium as indicated by the 16S rRNA clone library. Actinobacteria associated with the Algoa Bay sponge specimens were also cultured and the actinobacterial isolates were sent for screening against Mycobacterium aurum with two Kocuria kristinae isolates and a Streptomyces albdioflavus isolate showing good antimycobacterial activity. Advisors/Committee Members: Dorrington, R.A., Davies-Coleman, Michael Trevor.

Subjects/Keywords: Sponges – South Africa – Algoa Bay; Sponges – Classification; Metabolites – South Africa – Algoa Bay; Marine metabolites – South Africa – Algoa Bay; PQQ (Biochemistry); Bacterial diversity

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Walmsley, T. A. (2014). An investigation into the bacterial diversity associated with South African latrunculid sponges that produce bioactive secondary metabolites. (Doctoral Dissertation). Rhodes University. Retrieved from http://hdl.handle.net/10962/d1012943

Chicago Manual of Style (16^th Edition):

Walmsley, Tara Aisling. “An investigation into the bacterial diversity associated with South African latrunculid sponges that produce bioactive secondary metabolites.” 2014. Doctoral Dissertation, Rhodes University. Accessed January 22, 2021. http://hdl.handle.net/10962/d1012943.

MLA Handbook (7^th Edition):

Walmsley, Tara Aisling. “An investigation into the bacterial diversity associated with South African latrunculid sponges that produce bioactive secondary metabolites.” 2014. Web. 22 Jan 2021.

Vancouver:

Walmsley TA. An investigation into the bacterial diversity associated with South African latrunculid sponges that produce bioactive secondary metabolites. [Internet] [Doctoral dissertation]. Rhodes University; 2014. [cited 2021 Jan 22]. Available from: http://hdl.handle.net/10962/d1012943.

Council of Science Editors:

Walmsley TA. An investigation into the bacterial diversity associated with South African latrunculid sponges that produce bioactive secondary metabolites. [Doctoral Dissertation]. Rhodes University; 2014. Available from: http://hdl.handle.net/10962/d1012943

University College Cork

24. Jackson, Stephen A. Exploiting the diverse microbial ecology of marine sponges.

Degree: 2013, University College Cork

URL: http://hdl.handle.net/10468/1037

► Marine sponges (phylum Porifera) are the oldest extant metazoan animals on earth and host large populations of symbiotic microbes: Bacteria, Archaea and unicellular Eukaryota. Those… (more)

▼ Marine sponges (phylum Porifera) are the oldest extant metazoan animals on earth and host large populations of symbiotic microbes: Bacteria, Archaea and unicellular Eukaryota. Those microbes play ecological functions which are essential to the health of the host including carbon, nitrogen and sulfur cycling as well as host defence through the production of bioactive secondary metabolites which protect against infection and predation. The diversity of sponge-associated microbes is remarkable with thousands of OTUs reported from individual sponge species. Amongst those populations are sponge-specific microbes which may be specific to sponges or specific to sponge species. While marine natural product discovery concerns many animal phyla, Porifera account for the largest proportion of novel compounds. Evidence suggests that many of these compounds are the products of symbiotic microbes. Descriptions of sponge-associated microbial community structures have been advanced by the development of next-generation sequencing technologies while the discovery and exploitation of sponge derived bioactive compounds has increased due to developments in sequence-based and function-based metagenomics. Here, we use pyrosequencing to describe the bacterial communities associated with two shallow, temperate water sponges (Raspailia ramosa and Stelligera stuposa) from Irish coastal waters and to describe the bacterial and archaeal communities of a single sponge species (Inflatella pellicula) from two different depths in deep waters in the Atlantic Ocean, including at a depth of 2900m, a depth far greater than that of any previous sequence-based sponge-microbe investigation. We identified diverse microbial communities in all sponges and the presence of sponge-specific taxa recruiting to previously described and novel spongespecific clusters. We also identified archaeal communities which dominated sponge-microbe communities. We demonstrate that sponge-associated microbial communities differ from seawater communities indicating host selection processes. We used sequence-based metagenomic techniques to identify genes of potential industrial and pharmacological interest in the metagenomes of various sponge species and functionbased metagenomic screening in an attempt to identify lipolytic and antibacterial activities from metagenomic clones from the metagenome of the marine sponge Stelletta normani. In addition we have cultured diverse bacterial species from sponge tissues, many of which display antimicrobial activities against clinically relevant bacterial and yeast test strains. Other isolates represent novel species in the genus Maribacter and require emendments to the description of that genus. Advisors/Committee Members: Dobson, Alan D. W., Morrissey, John P., MarineInstitute.

Subjects/Keywords: Marine sponges; Porifera; Metazoa; Symbiotic microbes; Sponge derived bioactive compounds; Metagenomics; Pyrosequencing; Raspailia ramosa; Stelligera stuposa; Inflatella pellicula; Stelletta normani; Maribacter; Sponges

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APA (6^th Edition):

Jackson, S. A. (2013). Exploiting the diverse microbial ecology of marine sponges. (Thesis). University College Cork. Retrieved from http://hdl.handle.net/10468/1037

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Jackson, Stephen A. “Exploiting the diverse microbial ecology of marine sponges.” 2013. Thesis, University College Cork. Accessed January 22, 2021. http://hdl.handle.net/10468/1037.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Jackson, Stephen A. “Exploiting the diverse microbial ecology of marine sponges.” 2013. Web. 22 Jan 2021.

Vancouver:

Jackson SA. Exploiting the diverse microbial ecology of marine sponges. [Internet] [Thesis]. University College Cork; 2013. [cited 2021 Jan 22]. Available from: http://hdl.handle.net/10468/1037.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Jackson SA. Exploiting the diverse microbial ecology of marine sponges. [Thesis]. University College Cork; 2013. Available from: http://hdl.handle.net/10468/1037

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

25. Hassanzada, Caidra Elizabeth. Biodiversity and Ecological Dynamics of Sciophilous Benthic Communities on Artificial Plates: Emphasis on Reef Sponges.

Degree: 2015, Nova Southeastern University

URL: http://nsuworks.nova.edu/occ_stuetd/390

► Low light intensity habitats harbor unique sciophilous benthic communities and are a source of novel and unique sponge fauna. However, the community structure of these… (more)

Subjects/Keywords: Encrusting Sponges; Sponge assemblages; Species Richness; Cryptic Habitat; Marine Biology; Oceanography and Atmospheric Sciences and Meteorology

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APA (6^th Edition):

Hassanzada, C. E. (2015). Biodiversity and Ecological Dynamics of Sciophilous Benthic Communities on Artificial Plates: Emphasis on Reef Sponges. (Thesis). Nova Southeastern University. Retrieved from http://nsuworks.nova.edu/occ_stuetd/390

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Hassanzada, Caidra Elizabeth. “Biodiversity and Ecological Dynamics of Sciophilous Benthic Communities on Artificial Plates: Emphasis on Reef Sponges.” 2015. Thesis, Nova Southeastern University. Accessed January 22, 2021. http://nsuworks.nova.edu/occ_stuetd/390.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Hassanzada, Caidra Elizabeth. “Biodiversity and Ecological Dynamics of Sciophilous Benthic Communities on Artificial Plates: Emphasis on Reef Sponges.” 2015. Web. 22 Jan 2021.

Vancouver:

Hassanzada CE. Biodiversity and Ecological Dynamics of Sciophilous Benthic Communities on Artificial Plates: Emphasis on Reef Sponges. [Internet] [Thesis]. Nova Southeastern University; 2015. [cited 2021 Jan 22]. Available from: http://nsuworks.nova.edu/occ_stuetd/390.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Hassanzada CE. Biodiversity and Ecological Dynamics of Sciophilous Benthic Communities on Artificial Plates: Emphasis on Reef Sponges. [Thesis]. Nova Southeastern University; 2015. Available from: http://nsuworks.nova.edu/occ_stuetd/390

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Victoria University of Wellington

26. Keyzers, Robert Alexander. The Isolation of Biologically Active Secondary Metabolites from New Zealand Marine Organisms.

Degree: 2003, Victoria University of Wellington

URL: http://hdl.handle.net/10063/433

► An improved protocol for the screening of marine sponges using cyclic loading, PSDVB, and both 1D and 2D NMR spectroscopy is described. Using this new… (more)

Subjects/Keywords: New Zealand; Sponges; Secondary metabolism; Bioactive compounds; Marine metabolites

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APA (6^th Edition):

Keyzers, R. A. (2003). The Isolation of Biologically Active Secondary Metabolites from New Zealand Marine Organisms. (Doctoral Dissertation). Victoria University of Wellington. Retrieved from http://hdl.handle.net/10063/433

Chicago Manual of Style (16^th Edition):

Keyzers, Robert Alexander. “The Isolation of Biologically Active Secondary Metabolites from New Zealand Marine Organisms.” 2003. Doctoral Dissertation, Victoria University of Wellington. Accessed January 22, 2021. http://hdl.handle.net/10063/433.

MLA Handbook (7^th Edition):

Keyzers, Robert Alexander. “The Isolation of Biologically Active Secondary Metabolites from New Zealand Marine Organisms.” 2003. Web. 22 Jan 2021.

Vancouver:

Keyzers RA. The Isolation of Biologically Active Secondary Metabolites from New Zealand Marine Organisms. [Internet] [Doctoral dissertation]. Victoria University of Wellington; 2003. [cited 2021 Jan 22]. Available from: http://hdl.handle.net/10063/433.

Council of Science Editors:

Keyzers RA. The Isolation of Biologically Active Secondary Metabolites from New Zealand Marine Organisms. [Doctoral Dissertation]. Victoria University of Wellington; 2003. Available from: http://hdl.handle.net/10063/433

Rhodes University

27. Antunes, Edith Martins. Pyrroloiminoquinone metabolites from South African Latrunculid sponges.

Degree: Faculty of Science, Chemistry, 2003, Rhodes University

URL: http://hdl.handle.net/10962/d1005001

► An in depth chemical investigation of the major and minor pyrroloiminoquinone metabolites produced by four species of endemic South African Latrunculid sponges, collected from Algoa… (more)

▼ An in depth chemical investigation of the major and minor pyrroloiminoquinone metabolites produced by four species of endemic South African Latrunculid sponges, collected from Algoa Bay and the Tsitsikamma Marine Reserve off the south eastern coast of South Africa, yielded eleven new and twelve known pyrroloiminoquinone metabolites. The structures of the new metabolites were determined using standard spectroscopic techniques. Tsitsikamma pedunculata was shown to contain 7,8-dehydro-3-dihydro-discorhabdin C (2.1), 14-bromo-7,8-dehydro-3-dihydro-discorhabdin C (2.2), discorhabdin S (2.3), 14-bromo-1-hydroxy-discorhabdin S (2.4), 1-bromo-2-hydroxy-4-debromo-discorhabdin S (2.5), and 2,4-debromo-3-dihydro-discorhabdin C (2.6), together with the known compounds 14-bromo-discorhabdin C (1.51), 14-bromo-3-dihydro-discorhabdin C (1.52) and 3-dihydro-discorhabdin C. The metabolites from T. pedunculata were characterised by the presence of a reduced C-3 carbonyl and bromination at C-14. Compounds isolated from a second Latrunculid sponge, Latrunculia lorii, ranged from a substituted bicyclic pyrrolecarboxylic acid, makaluvic acid A (1.47), to the simple tricyclic known pyrroloiminoquinones makaluvamine C (1.33) and damirone B (1.20) and the more complex discorhabdin D type metabolites, discorhabdin M (3.2), 1-amino discorhabdin D (3.3), 1-methoxy discorhabdin D (3.4) and 1-alanyl discorhabdin D (3.5). Discorhabdin G* (3.1) was also isolated and characterised. This is the first reported occurrence of the known compounds 1.20, 1.33 and 1.47 in a Latrunculia sponge. Discorhabdin and bis-pyrroloiminoquinone type compounds predominated in Tsitsikamma favus. Three known, tsitsikammamines A (1.71) and B (1.72), 1.52, and five new pyrroloiminoquinones, tsitsikammamine N-oxime (4.1), tsitsikammamine B N-oxime (4.2), 2.1, 2.4 and 2.6, were isolated from this sponge. A fourth Latrunculid sponge (Strongylodesma sp.) yielded three known compounds, discorhabdins A (1.57), D (1.61) and 1.53, and one new pyrroloiminoquinone 3.3. The dual role of these metabolites as cytotoxic agents and pigments resulted in an attempt to relate the photochemical properties of these metabolites to their cytotoxicity. The pyrroloiminoquinone metabolites studied exhibited moderate singlet oxygen quantum yields, while three compounds (1.57, 4.1 and 4.2) were shown to be capable of producing radicals at a wavelength of 532 nm. The possibility of a correlation between the electrochemical properties and anti-cancer (HCT-116) activity of selected pyrroloiminoquinones was explored. A study of the oesophageal and ovarian cytotoxicities of two pyrroloiminoquinones (1.57 and 1.72), together with an investigation into the intercalation and topoisomerase I inhibitory activity of the bis-pyrroloiminoquinones (1.71, 1.72, 4.1 and 4.2), are presented.

Subjects/Keywords: Sponges – South Africa; PQQ (Biochemistry); Marine metabolites – South Africa

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Antunes, E. M. (2003). Pyrroloiminoquinone metabolites from South African Latrunculid sponges. (Thesis). Rhodes University. Retrieved from http://hdl.handle.net/10962/d1005001

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Antunes, Edith Martins. “Pyrroloiminoquinone metabolites from South African Latrunculid sponges.” 2003. Thesis, Rhodes University. Accessed January 22, 2021. http://hdl.handle.net/10962/d1005001.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Antunes, Edith Martins. “Pyrroloiminoquinone metabolites from South African Latrunculid sponges.” 2003. Web. 22 Jan 2021.

Vancouver:

Antunes EM. Pyrroloiminoquinone metabolites from South African Latrunculid sponges. [Internet] [Thesis]. Rhodes University; 2003. [cited 2021 Jan 22]. Available from: http://hdl.handle.net/10962/d1005001.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Antunes EM. Pyrroloiminoquinone metabolites from South African Latrunculid sponges. [Thesis]. Rhodes University; 2003. Available from: http://hdl.handle.net/10962/d1005001

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universitat de Barcelona

28. López Acosta, María. Silicon consumption by marine sponges: an empirical approach and its ecological implications.

Degree: Departament de Biologia Evolutiva, Ecologia i Ciències Ambientals, 2018, Universitat de Barcelona

URL: http://hdl.handle.net/10803/663476

► El silicio (Si), en su forma disuelta de ácido silícico (DSi), es un nutriente clave en el océano. Su disponibilidad en los ecosistemas marinos la… (more)

▼ El silicio (Si), en su forma disuelta de ácido silícico (DSi), es un nutriente clave en el océano. Su disponibilidad en los ecosistemas marinos la regulan varios grupos de organismos, los cuales consumen DSi para construir sus esqueletos de sílice (BSi). Debido a que las diatomeas son el consumidor de Si más abundante, los intentos por cuantificar el uso del Si en el océano se han centrado principalmente en estos organismos, considerando el papel de los otros usuarios de Si como irrelevante. Durante las últimas décadas, algunos estudios han sugerido que al menos otro grupo, las esponjas silíceas, también están jugando un papel no-despreciable en el consumo de Si en los ecosistemas marinos. Las esponjas marinas son animales abundantes en los ecosistemas bentónicos. Es sorprendente que, pese a que el 80% de las especies necesitan DSi para formar sus esqueletos, casi no existe información disponible sobre cómo las esponjas consume dicho nutriente. De hecho, antes del comienzo de esta tesis (inicios del 2014), solo unos pocos estudios habían investigado el consumo de DSi en esponjas marinas, con modelos cinéticos sólo disponibles para dos géneros de demosponjas. Así, el principal objetivo de este trabajo fue mejorar el conocimiento general de cómo las esponjas utilizan DSi, facilitando futuras cuantificaciones del papel de las esponjas como usuarias de Si. Primero, investigamos las cinéticas de consumo de DSi en cinco especies de esponjas, incluida, por primera vez, una especie de la Clase Hexactinellida. También examinamos las fuentes de variabilidad entre especies y entre individuos, detectando que en algunas especies pueden ocurrir cambios estacionales en las cinéticas de consumo. Además, determinamos por primera vez la tasa de uso de DSi en esponjas en su hábitat natural (in situ). Los resultados, significativamente concordantes con los estimados por modelos cinéticos obtenidos en el laboratorio, respaldan el uso de incubaciones largas (>24h) en el laboratorio para investigar las cinéticas de consumo de DSi en esponjas. Finalmente, usamos toda la información empíricamente obtenida durante esta tesis para estimar el uso de DSi por parte de una comunidad de esponjas al nivel de ecosistema: la bahía de Brest (Francia). En resumen, este trabajo muestra que las esponjas tienen un papel relevante como usuarios de Si, incluso en un ecosistema somero en donde las diatomeas contribuyen ampliamente a la biomasa fitoplanctónica. Nuestros resultados también indican que el papel de las esponjas en los ecosistemas marinos aumenta junto con la disponibilidad de DSi. Por tanto, se predice que las esponjas jueguen un papel importante como usuarios de Si en hábitats profundos y de latitudes altas, caracterizados por alta disponibilidad de DSi. Todo ello indica que las esponjas silíceas deben ser consideradas como usuarios de DSi si queremos cuantificar de forma precisa el ciclo del Si a través de los ecosistemas marinos. Advisors/Committee Members: [email protected] (authoremail), false (authoremailshow), Maldonado Barahona, Manuel (director), Palacín Cabañas, Cruz (tutor), true (authorsendemail).

Subjects/Keywords: Esponges; Esponjas; Sponges; Ecologia marina; Ecología marina; Marine ecology; Silici; Silicio; Silicon; Ciències Experimentals i Matemàtiques; 504

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

López Acosta, M. (2018). Silicon consumption by marine sponges: an empirical approach and its ecological implications. (Thesis). Universitat de Barcelona. Retrieved from http://hdl.handle.net/10803/663476

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

López Acosta, María. “Silicon consumption by marine sponges: an empirical approach and its ecological implications.” 2018. Thesis, Universitat de Barcelona. Accessed January 22, 2021. http://hdl.handle.net/10803/663476.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

López Acosta, María. “Silicon consumption by marine sponges: an empirical approach and its ecological implications.” 2018. Web. 22 Jan 2021.

Vancouver:

López Acosta M. Silicon consumption by marine sponges: an empirical approach and its ecological implications. [Internet] [Thesis]. Universitat de Barcelona; 2018. [cited 2021 Jan 22]. Available from: http://hdl.handle.net/10803/663476.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

López Acosta M. Silicon consumption by marine sponges: an empirical approach and its ecological implications. [Thesis]. Universitat de Barcelona; 2018. Available from: http://hdl.handle.net/10803/663476

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Florida Atlantic University

29. Conkling, Megan. Cellular Basis of Sponge-Sponge Associations.

Degree: MS, 2017, Florida Atlantic University

URL: http://purl.flvc.org/fau/fd/FA00004848 ; (URL) http://purl.flvc.org/fau/fd/FA00004848

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Summary: Marine sponges interact and coexist with many different organisms. A two-sponge association between Amphimedon erina and Geodia gibberosa commonly occurs in the Florida Keys.… (more)

Subjects/Keywords: Sponges – Habitat – Florida.; Marine invertebrates – Florida.; Aquatic invertebrates – Cultures and culture media.; Apoptosis.; Cell culture.; Symbiosis.

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Conkling, M. (2017). Cellular Basis of Sponge-Sponge Associations. (Masters Thesis). Florida Atlantic University. Retrieved from http://purl.flvc.org/fau/fd/FA00004848 ; (URL) http://purl.flvc.org/fau/fd/FA00004848

Chicago Manual of Style (16^th Edition):

Conkling, Megan. “Cellular Basis of Sponge-Sponge Associations.” 2017. Masters Thesis, Florida Atlantic University. Accessed January 22, 2021. http://purl.flvc.org/fau/fd/FA00004848 ; (URL) http://purl.flvc.org/fau/fd/FA00004848.

MLA Handbook (7^th Edition):

Conkling, Megan. “Cellular Basis of Sponge-Sponge Associations.” 2017. Web. 22 Jan 2021.

Vancouver:

Conkling M. Cellular Basis of Sponge-Sponge Associations. [Internet] [Masters thesis]. Florida Atlantic University; 2017. [cited 2021 Jan 22]. Available from: http://purl.flvc.org/fau/fd/FA00004848 ; (URL) http://purl.flvc.org/fau/fd/FA00004848.

Council of Science Editors:

Conkling M. Cellular Basis of Sponge-Sponge Associations. [Masters Thesis]. Florida Atlantic University; 2017. Available from: http://purl.flvc.org/fau/fd/FA00004848 ; (URL) http://purl.flvc.org/fau/fd/FA00004848

30. Bastos de lemos e silva, Siguara. Chimie et biosynthèse de substances naturelles hautement complexes de la biodiversité méditerranéenne : Chemistry and biosynthesis of highly complex marine alkaloids from Mediterranean biodiversity.

Degree: Docteur es, Chimie des substances naturelles, 2017, Université Paris-Saclay (ComUE)

URL: http://www.theses.fr/2017SACLS214

►

Le but de ce travail de doctorat est l’étude chimique et biosynthétique de familles d’alcaloïdes guanidiniques d’origine marine provenant d’éponges de Méditerranée.Le travail est divisé… (more)

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Le but de ce travail de doctorat est l’étude chimique et biosynthétique de familles d’alcaloïdes guanidiniques d’origine marine provenant d’éponges de Méditerranée.Le travail est divisé en trois parties successives : 1) l’isolement d’alcaloïdes produits par des éponges marines de l’ordre des Poeciloscerida; 2) l’élucidation de la biosynthèse de la crambescine C1 par des études in vivo d’incorporation de précurseurs marqués au 14C; 3) la synthèse biomimétique de la crambescine A2 448 et de dérivés proches.La famille des alcaloïdes guanidiniques cycliques des crambescines est au coeur de la thèse, ces substances naturelles sont produites par l’éponge incrustante Crambe crambe. Ces alcaloïdes ont été découverts dans les années 1990 et ont suscité beaucoup d’intérêt pour leurs propriétés biologiques et écologiques et leurs synthèses totales. Par contre, leur biosynthèse était encore inconnue à ce jour. La seule synthèse biomimétique disponible était basée sur une hypothèse d’origine polyacétique. Les hypothèses récentes de nos groupes ont permis de mettre en avant une origine mixte: la partie cyclique guanidinique proviendrait d’un pyrrolidinium issu de l’arginine et d’un précurseur “céto-acide” proche des acides gras. Sur la base de cette hypothèse, nous avons mis au point une expérience d’incorporation qui a ensuite inspirée une voie de synthèse biomimétique pour l’accès aux crambescines et dérivés. Les premières conclusions quant à l’origine biosynthétique de ces molécules sont les faits les plus marquants de ce travail. Nous apportons une meilleure compréhension de la biochimie des alcaloïdes guanidiniques marins de structures complexes.

This thesis aims at the study of the chemical and biogenetic origin of specialized guanidine-alkaloid metabolites produced by sponges from the Mediterranean Sea.The work is divided into three main parts: 1) isolation of alkaloids produced by sponges of the Poeciloscerida order; 2) biosynthesis of crambescin C1 by in-vivo 14C-feeding experiments with Crambe crambe sponge; 3) biomimetic synthesis of crambescin A2 448 and derivatives. The main focus of the thesis will be the family of cyclic-guanidine alkaloids "crambescins", produced by the red incrusting sponge Crambe crambe.These alkaloids were discovered in the early 90s and despite the large interest on their biological activities, ecological roles, and synthesis, their biosynthesis is still unknown.The only available biomimetic synthesis of crambescins was based on a fully polyketide origin hypothesis. Recently our groups suggested an alternative biosynthetic hypothesis in which the guanidine-core would be originated from a condensation between a guanidinated pyrrolidinium derived from arginine and a beta-keto fatty acid. Based on this hypothesis, we designed a biosynthesis experiment that inspired a biomimetic synthesis route to access the crambescins and derivatives. The insights from these studies are the first experimental conclusions about the biosynthesis of crambescins. Finally, this work leads to a better comprehension…

Advisors/Committee Members: Poupon, Erwan (thesis director).

Subjects/Keywords: Substances naturelles; Alcaloïdes; Biosynthèse; Synthèse biomimétique; Éponges marines; Natural products; Alkaloids; Biosynthesis; Biomimetic synthesis; Marine sponges

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Bastos de lemos e silva, S. (2017). Chimie et biosynthèse de substances naturelles hautement complexes de la biodiversité méditerranéenne : Chemistry and biosynthesis of highly complex marine alkaloids from Mediterranean biodiversity. (Doctoral Dissertation). Université Paris-Saclay (ComUE). Retrieved from http://www.theses.fr/2017SACLS214

Chicago Manual of Style (16^th Edition):

Bastos de lemos e silva, Siguara. “Chimie et biosynthèse de substances naturelles hautement complexes de la biodiversité méditerranéenne : Chemistry and biosynthesis of highly complex marine alkaloids from Mediterranean biodiversity.” 2017. Doctoral Dissertation, Université Paris-Saclay (ComUE). Accessed January 22, 2021. http://www.theses.fr/2017SACLS214.

MLA Handbook (7^th Edition):

Bastos de lemos e silva, Siguara. “Chimie et biosynthèse de substances naturelles hautement complexes de la biodiversité méditerranéenne : Chemistry and biosynthesis of highly complex marine alkaloids from Mediterranean biodiversity.” 2017. Web. 22 Jan 2021.

Vancouver:

Bastos de lemos e silva S. Chimie et biosynthèse de substances naturelles hautement complexes de la biodiversité méditerranéenne : Chemistry and biosynthesis of highly complex marine alkaloids from Mediterranean biodiversity. [Internet] [Doctoral dissertation]. Université Paris-Saclay (ComUE); 2017. [cited 2021 Jan 22]. Available from: http://www.theses.fr/2017SACLS214.

Council of Science Editors:

Bastos de lemos e silva S. Chimie et biosynthèse de substances naturelles hautement complexes de la biodiversité méditerranéenne : Chemistry and biosynthesis of highly complex marine alkaloids from Mediterranean biodiversity. [Doctoral Dissertation]. Université Paris-Saclay (ComUE); 2017. Available from: http://www.theses.fr/2017SACLS214

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