subject:(Mammary Glands Animal metabolism 60)

1. Roarty, Kevin Patrick. The role of TGF-[beta] and Wnt5a in mammary gland development and tumorigenesis.

Degree: PhD, 2008, University of Alabama – Birmingham

URL: http://contentdm.mhsl.uab.edu/u?/etd,337

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Breast cancer is the second most common cancer worldwide behind lung cancer, affecting women of all ages, races, ethnicities, and socioeconomic strata. Concerted efforts have… (more)

Subjects/Keywords: Gene Expression Regulation, Developmental <; br>; Mammary Glands, Animal – growth & development <; br>; Mammary Glands, Animal – metabolism <; br>; Transforming Growth Factor beta1 – pharmacology <; br>; Wnt Proteins – metabolism

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Roarty, K. P. (2008). The role of TGF-[beta] and Wnt5a in mammary gland development and tumorigenesis. (Doctoral Dissertation). University of Alabama – Birmingham. Retrieved from http://contentdm.mhsl.uab.edu/u?/etd,337

Chicago Manual of Style (16^th Edition):

Roarty, Kevin Patrick. “The role of TGF-[beta] and Wnt5a in mammary gland development and tumorigenesis.” 2008. Doctoral Dissertation, University of Alabama – Birmingham. Accessed December 05, 2019. http://contentdm.mhsl.uab.edu/u?/etd,337.

MLA Handbook (7^th Edition):

Roarty, Kevin Patrick. “The role of TGF-[beta] and Wnt5a in mammary gland development and tumorigenesis.” 2008. Web. 05 Dec 2019.

Vancouver:

Roarty KP. The role of TGF-[beta] and Wnt5a in mammary gland development and tumorigenesis. [Internet] [Doctoral dissertation]. University of Alabama – Birmingham; 2008. [cited 2019 Dec 05]. Available from: http://contentdm.mhsl.uab.edu/u?/etd,337.

Council of Science Editors:

Roarty KP. The role of TGF-[beta] and Wnt5a in mammary gland development and tumorigenesis. [Doctoral Dissertation]. University of Alabama – Birmingham; 2008. Available from: http://contentdm.mhsl.uab.edu/u?/etd,337

2. Raghuraman, Nandini. Prepubertal bisphenol A exposure in the rat mammary gland : mechanism of action for carcinogenesis.

Degree: MS, 2007, University of Alabama – Birmingham

URL: http://contentdm.mhsl.uab.edu/u?/etd,586

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Bisphenol A (BPA) is commonly used in the production of polycarbonate plastic, epoxy resins, and dental sealants. BPA has been shown to advance puberty and… (more)

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Bisphenol A (BPA) is commonly used in the production of polycarbonate plastic, epoxy resins, and dental sealants. BPA has been shown to advance puberty and disrupt estrous cyclicity, identifying it as an endocrine disruptor. It has previously been reported that rats treated with BPA during the prepubertal period are more susceptible to irregular estrous cycles since hormone levels during this period can result in permanent changes due to developmental programming. The goal of this research was to identify differentially expressed proteins in mammary glands of rats treated early in postnatal life with BPA. For this study, lactating dams were gavaged with 250 μg BPA/kg body weight or an equivalent volume of sesame oil on days 1-20 post partum. Mammary glands from 21 and 50-day rats were subjected to 2-D gel electrophoresis and mass spectrometry for discovery proteomics or paraffin blocked for proliferation and apoptosis IHC studies. Using 2-D gel analysis, MALDI-TOF mass spectrometry, and western blot analysis we have determined that GRP78 was down regulated and RAD51 homolog 2 was up-regulated in mammary glands of BPA treated compared to control treated 21 day old rats. Immuno-blot analysis confirmed the differential regulation and identity of these proteins. RAD51 homolog 2 functions in DNA maintenance, participating in a common DNA damage response pathway associated with double-strand break repair, an observation that points to BPA’s potential to cause DNA damage. GRP78 is a chaperone protein involved in the folding and assembly of proteins, down-regulation of which can result in excessive cellular stress. Ki67 staining showed a slight, but not significant increase in cell proliferation in 50-day treated groups. The rate of apoptosis was significantly decreased in 50-day old BPA treated rats as compared to control. Prepubertal BPA exposure, hence, has the ability to increase susceptibility to chemically induced mammary cancer by regulating important proteins in the DNA damage response and protein folding pathways, as well as altering apoptosis.

M.S.

1 online resource (x, 32 p.) : ill. (some col.), facsim., digital, PDF file.

Biology

Natural Sciences and Mathematics

UNRESTRICTED

Advisors/Committee Members: Lamartiniere, Coral A., Robert Angus, Stephen A. Watts.

Subjects/Keywords: Bisphenol A – Physiological effect <; br>; Bisphenol A – Mechanism of action <; br>; Mammary glands – Effect of chemicals on <; br>; Mammary glands – Cancer – Susceptibility <; br>; Mammary glands – Cancer – Animal models <; br>; DNA damage <; br>; Rats – Physiology.

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Raghuraman, N. (2007). Prepubertal bisphenol A exposure in the rat mammary gland : mechanism of action for carcinogenesis. (Masters Thesis). University of Alabama – Birmingham. Retrieved from http://contentdm.mhsl.uab.edu/u?/etd,586

Chicago Manual of Style (16^th Edition):

Raghuraman, Nandini. “Prepubertal bisphenol A exposure in the rat mammary gland : mechanism of action for carcinogenesis.” 2007. Masters Thesis, University of Alabama – Birmingham. Accessed December 05, 2019. http://contentdm.mhsl.uab.edu/u?/etd,586.

MLA Handbook (7^th Edition):

Raghuraman, Nandini. “Prepubertal bisphenol A exposure in the rat mammary gland : mechanism of action for carcinogenesis.” 2007. Web. 05 Dec 2019.

Vancouver:

Raghuraman N. Prepubertal bisphenol A exposure in the rat mammary gland : mechanism of action for carcinogenesis. [Internet] [Masters thesis]. University of Alabama – Birmingham; 2007. [cited 2019 Dec 05]. Available from: http://contentdm.mhsl.uab.edu/u?/etd,586.

Council of Science Editors:

Raghuraman N. Prepubertal bisphenol A exposure in the rat mammary gland : mechanism of action for carcinogenesis. [Masters Thesis]. University of Alabama – Birmingham; 2007. Available from: http://contentdm.mhsl.uab.edu/u?/etd,586

3. Jenkins, Sarah B. The effects of bisphenol A (BPA) on ErbB2-positive breast cancer.

Degree: PhD, 2009, University of Alabama – Birmingham

URL: http://contentdm.mhsl.uab.edu/u?/etd,808

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Bisphenol A (BPA) is a synthetically made compound used to produce a myriad of consumer goods. Recent studies have shown BPA to leach from these… (more)

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Bisphenol A (BPA) is a synthetically made compound used to produce a myriad of consumer goods. Recent studies have shown BPA to leach from these products in appreciable amounts, resulting in nearly ubiquitous exposure. In this study, we assessed whether chronic administration to a range of low concentrations of BPA could accelerate spontaneously developing mammary cancer using a transgenic model that over-expresses wild type ErbB2/neu transgene (MMTV-erbB2). MMTV-erbB2 mice were provided drinking water containing 0 (control), 2.5 (BPA 2.5), 25 (BPA 25), 250 (BPA 250), or 2500 (BPA 2500) μg BPA/L from eight weeks of age until sacrifice. This range of BPA concentrations can be divided into two categories: 1) environmentally relevant doses of BPA (BPA 2.5 and BPA 25), and 2) regulatory-based doses of BPA (BPA 250 and BPA 2500). Chronic consumption of BPA 2.5 and BPA 25 significantly decreased tumor latency and increased tumor multiplicity, burden, and the rate of pulmonary metastasis. All doses of BPA significantly increased cell proliferation in the mammary gland. The rate of apoptosis was increased in the higher doses, with BPA 2500 achieving statistical significance. When these end points were taken together to estimate a ratio of cellproliferation- to-apoptosis in the mammary gland, a non-monotonic dose response resulted. This end point provided the best prediction of effects induced by each concentration of BPA on mammary tumor development in MMTV-erbB2 mice. Changes in response to representative doses from environmentally relevant (BPA 25) and regulatory-based (BPA 2500) doses of BPA were noted. BPA 25 treatment significantly stunted mammary gland development. It suppressed ductal tree length, extension, and area while increasing the average number of terminal end buds present in the mammary gland. BPA 25 significantly decreased the protein expression of estrogen receptor alpha and progesterone receptor A while significantly increasing expression and activation of erbB2, erbB3, IGF-1 receptor, and Akt. These effects were absent from BPA 2500. Collectively, these effects are likely due to the ability of BPA 25, but not BPA 2500, to retard mammary gland growth and development and cause aberrant activation of growth factor receptor and Akt signaling in the mammary gland.

1 online resource (xiii, 158 p. : ill., digital, PDF file)

Pharmacology and Toxicology;

Joint Health Sciences;

Bisphenol A ErbB2 mammary gland

UNRESTRICTED

Advisors/Committee Members: Lamartiniere, Coral A., Carpenter, D. Mark , Eltoum, Isam-Eldin , Grubbs, Clinton J. , Krontiras, Helen , Mobley, James A..

Subjects/Keywords: 9,10-Dimethyl-1,2-benzanthracene – toxicity<; br>; Carcinogens – toxicity<; br>; Mammary Glands, Animal – drug effects<; br>; Phenols – toxicity

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Jenkins, S. B. (2009). The effects of bisphenol A (BPA) on ErbB2-positive breast cancer. (Doctoral Dissertation). University of Alabama – Birmingham. Retrieved from http://contentdm.mhsl.uab.edu/u?/etd,808

Chicago Manual of Style (16^th Edition):

Jenkins, Sarah B. “The effects of bisphenol A (BPA) on ErbB2-positive breast cancer.” 2009. Doctoral Dissertation, University of Alabama – Birmingham. Accessed December 05, 2019. http://contentdm.mhsl.uab.edu/u?/etd,808.

MLA Handbook (7^th Edition):

Jenkins, Sarah B. “The effects of bisphenol A (BPA) on ErbB2-positive breast cancer.” 2009. Web. 05 Dec 2019.

Vancouver:

Jenkins SB. The effects of bisphenol A (BPA) on ErbB2-positive breast cancer. [Internet] [Doctoral dissertation]. University of Alabama – Birmingham; 2009. [cited 2019 Dec 05]. Available from: http://contentdm.mhsl.uab.edu/u?/etd,808.

Council of Science Editors:

Jenkins SB. The effects of bisphenol A (BPA) on ErbB2-positive breast cancer. [Doctoral Dissertation]. University of Alabama – Birmingham; 2009. Available from: http://contentdm.mhsl.uab.edu/u?/etd,808

4. Baxley, Sarah. The role of WNT5A in mammary gland development.

Degree: PhD, 2010, University of Alabama – Birmingham

URL: http://contentdm.mhsl.uab.edu/u?/etd,1812

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Transforming growth factor {esc}gb {esc}s(TGF-{esc}gb{esc}s) negatively regulates mammary gland development and requires Wnt5a to exert some of these effects on mammary gland development. Wnt5a is… (more)

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Transforming growth factor {esc}gb {esc}s(TGF-{esc}gb{esc}s) negatively regulates mammary gland development and requires Wnt5a to exert some of these effects on mammary gland development. Wnt5a is a non-canonical signaling Wnt that is expressed in all stages of mammary gland development except lactation. Using slow release pellets containing Wnt5a, as well as Wnt5a null tissue, we previously showed that Wnt5a also acts to limit mammary development. Initial studies revealed a potential role for TGF-{esc}gb {esc}sand Wnt5a in regulating mammary gland progenitor cells, indicating they may act to regulate the stem and progenitor cell population. In order to study the role of Wnt5a on mammary stem and progenitor cell maintenance, we wanted to create a new mouse model. Here, we generated transgenic mice that overexpress Wnt5a in the mammary epithelium using the MMTV promoter (M5a mice). Lactation was impaired in two high Wnt5a expressing lines. Lactation defects could not be explained by differences in apoptosis, lineage differentiation, milk synthesis or secretion. Instead, Wnt5a overexpression led to a failure in oxytocin response and milk ejection, similar to mice with a mutation in Connexin43 (Cx43), we examined Cx43 phosphorylation and localization in M5a mice. In wild type mice, Cx43 switched from a phosphorylated to a more hypophosphorylated form after parturition. In contrast, Cx43 was maintained in the phosphorylated form after parturition in M5a mice. Similarly, mammary myoepithelial cells grown in culture and treated with Wnt5a exhibited altered Cx43 phosphorylation relative to vehicle treated control cells. We propose that Wnt5a inhibits the response to oxytocin and prevents milk ejection through regulation of Cx43 phosphorylation. Additionally, we examined the effects of Wnt5a and TGF-{esc}gb {esc}son mammary stem cell populations and found no direct, significant effects on stem cell number. Although Wnt5a and TGF-{esc}gb {esc}smay not regulate stem cell number, we hypothesize they may direct other aspects of stem or progenitor cell maintenance, such as progenitor proliferation or stem cell self-renewal. Overall, we conclude that Wnt5a and TGF-{esc}gb {esc}smay regulate the mammary progenitor cell population. Additionally, Wnt5a overexpression can alter mammary Cx43 phosphorylation at parturition, inhibiting the milk ejection response.

1 online resource (x, 85 pages) :illustrations

University of Alabama at Birmingham2010.

Cell Biology

Joint Health Sciences

UNRESTRICTED

Advisors/Committee Members: Rosa Serra, Anupam Agarwal , Chenbei Chang , Andra Frost , Christopher Klug , Jianbo Wang..

Subjects/Keywords: Breast Neoplasms<; br>; Lactation<; br>; Mammary Glands, Animal – metabolism<; br>; Mammary Neoplasms, Experimental – metabolism.<; br>; Transforming Growth Factor beta – metabolism<; br>; Wnt Proteins – metabolism.

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Baxley, S. (2010). The role of WNT5A in mammary gland development. (Doctoral Dissertation). University of Alabama – Birmingham. Retrieved from http://contentdm.mhsl.uab.edu/u?/etd,1812

Chicago Manual of Style (16^th Edition):

Baxley, Sarah. “The role of WNT5A in mammary gland development.” 2010. Doctoral Dissertation, University of Alabama – Birmingham. Accessed December 05, 2019. http://contentdm.mhsl.uab.edu/u?/etd,1812.

MLA Handbook (7^th Edition):

Baxley, Sarah. “The role of WNT5A in mammary gland development.” 2010. Web. 05 Dec 2019.

Vancouver:

Baxley S. The role of WNT5A in mammary gland development. [Internet] [Doctoral dissertation]. University of Alabama – Birmingham; 2010. [cited 2019 Dec 05]. Available from: http://contentdm.mhsl.uab.edu/u?/etd,1812.

Council of Science Editors:

Baxley S. The role of WNT5A in mammary gland development. [Doctoral Dissertation]. University of Alabama – Birmingham; 2010. Available from: http://contentdm.mhsl.uab.edu/u?/etd,1812

The Ohio State University

5. Read, Merrill S. The effect of hormones on the intermediary metabolism of mammary glands.

Degree: PhD, Graduate School, 1956, The Ohio State University

URL: http://rave.ohiolink.edu/etdc/view?acc_num=osu1485795295568557

Subjects/Keywords: Chemistry; Hormones; Mammary glands; Metabolism

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Read, M. S. (1956). The effect of hormones on the intermediary metabolism of mammary glands. (Doctoral Dissertation). The Ohio State University. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=osu1485795295568557

Chicago Manual of Style (16^th Edition):

Read, Merrill S. “The effect of hormones on the intermediary metabolism of mammary glands.” 1956. Doctoral Dissertation, The Ohio State University. Accessed December 05, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=osu1485795295568557.

MLA Handbook (7^th Edition):

Read, Merrill S. “The effect of hormones on the intermediary metabolism of mammary glands.” 1956. Web. 05 Dec 2019.

Vancouver:

Read MS. The effect of hormones on the intermediary metabolism of mammary glands. [Internet] [Doctoral dissertation]. The Ohio State University; 1956. [cited 2019 Dec 05]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=osu1485795295568557.

Council of Science Editors:

Read MS. The effect of hormones on the intermediary metabolism of mammary glands. [Doctoral Dissertation]. The Ohio State University; 1956. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=osu1485795295568557

6. Cook, Leah M. (Leah Marie). Understanding molecular mechanisms of breast cancer metastasis using genetically-engineered mice.

Degree: PhD, 2011, University of Alabama – Birmingham

URL: http://contentdm.mhsl.uab.edu/u?/etd,1045

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Morbidity and mortality of breast cancer patients are drastically increased when primary tumor cells metastasize to distant organ sites. Effective treatment of metastatic disease has… (more)

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Morbidity and mortality of breast cancer patients are drastically increased when primary tumor cells metastasize to distant organ sites. Effective treatment of metastatic disease has been limited; therefore, an increased molecular understanding to identify biomarkers and therapeutic targets is needed. Breast cancer metastasis suppressor 1 (BRMS1) suppresses development of metastases when expressed in a variety of cancer types, including metastatic mammary carcinoma. Little is known of Brms1 function throughout the initiation and progression of mammary carcinoma. Thus Brms1 transgenic mice (derived on C57BL/6 background) were generated by utilizing MMTV promoter expression (for mammary-selective overexpression) or the β-actin promoter (for ubiquitous Brms1 overexpression) fused to Brms1 cDNA. The goal of this study was to investigate mechanisms of Brms1- mediated metastasis suppression in transgenic mice that express Brms1 using polyoma middle T (PyMT) oncogeneinduced models. Brms1 expression did not significantly alter onset or growth of the primary tumors. When expressed ubiquitously, Brms1 suppressed pulmonary metastasis and promoted apoptosis of tumor cells located in the lungs but not in the mammary glands. Ubiquitous Brms1 overexpression also altered cytokine signaling in primary tumors, a phenomenon that has not been previously reported. Surprisingly, selective expression of Brms1 in the mammary gland using the MMTV promoter did not significantly block metastasis nor did it promote apoptosis in lungs. To determine the impact of host genetic background on Brms1-mediated metastasis suppression, congenic PyMT mice were crossed with Brms1 transgenic mice. Brms1 expression did not significantly alter primary tumor onset or growth. Ubiquitous Brms1 overexpression suppressed metastasis when compared to control littermates, though not significantly. Interestingly, there was no development of metastasis when Brms1 was overexpressed selectively in mammary glands of congenic crossed mice. These results show that tissue- or cell type-specific over-expression of Brms1 is important for Brms1-mediated metastasis suppression. Brms1-mediated apoptosis at secondary tissue sites may be a potential mechanism of metastasis suppression. Additionally, these results suggest that Brms1-mediated metastasis suppression is dependent on host genetic background. Understanding tissue- or cell-specific expression of Brms1 and how host genetics modify Brms1 function will be a major advance to enable correct interpretation of clinical samples.

1 online resource (xiii, 150 p.) : ill., digital, PDF file.

Pathology;

Joint Health Sciences;

mammary carcinoma metastasis metastasis suppressor gene mouse models transgenic polyoma middle T

UNRESTRICTED

Advisors/Committee Members: Welch, Danny R., Hurst, Douglas R. , Carroll, Steven L. , Frost, Andra A. , Grubbs, Clinton J. , Lamartiniere, Coral A. , Serra, Rosa A..

Subjects/Keywords: Breast Neoplasms – pathology<; br>; Mammary Neoplasms, Animal<; br>; Mice, Transgenic<; br>; Neoplasm Metastasis – pathology<; br>; Tumor Microenvironment<; br>; Tumor Suppressor Proteins – genetics<; br>; Tumor Suppressor Proteins – metabolism

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Cook, L. M. (. M. (2011). Understanding molecular mechanisms of breast cancer metastasis using genetically-engineered mice. (Doctoral Dissertation). University of Alabama – Birmingham. Retrieved from http://contentdm.mhsl.uab.edu/u?/etd,1045

Chicago Manual of Style (16^th Edition):

Cook, Leah M (Leah Marie). “Understanding molecular mechanisms of breast cancer metastasis using genetically-engineered mice.” 2011. Doctoral Dissertation, University of Alabama – Birmingham. Accessed December 05, 2019. http://contentdm.mhsl.uab.edu/u?/etd,1045.

MLA Handbook (7^th Edition):

Cook, Leah M (Leah Marie). “Understanding molecular mechanisms of breast cancer metastasis using genetically-engineered mice.” 2011. Web. 05 Dec 2019.

Vancouver:

Cook LM(M. Understanding molecular mechanisms of breast cancer metastasis using genetically-engineered mice. [Internet] [Doctoral dissertation]. University of Alabama – Birmingham; 2011. [cited 2019 Dec 05]. Available from: http://contentdm.mhsl.uab.edu/u?/etd,1045.

Council of Science Editors:

Cook LM(M. Understanding molecular mechanisms of breast cancer metastasis using genetically-engineered mice. [Doctoral Dissertation]. University of Alabama – Birmingham; 2011. Available from: http://contentdm.mhsl.uab.edu/u?/etd,1045

Massey University

7. Biet, Juliane. Effect of mechanical stress o the integrity, signalling mechanisms and function of bovine mammary epithelial cells : a thesis submitted in partial fulfilment of the requirements for the degree of Doctor of Philosophy in Animal Science at Massey University, Manawatū, Palmerston North, New Zealand .

Degree: 2014, Massey University

URL: http://hdl.handle.net/10179/7214

► Mammary gland engorgement due to milk accumulation in late lactation leads to changes in cell morphology and has been recognised as a potential key initiator… (more)

▼ Mammary gland engorgement due to milk accumulation in late lactation leads to changes in cell morphology and has been recognised as a potential key initiator of involution and remodelling of the mammary gland. The physical distension of mammary epithelial cells (MEC), due to udder filling, is likely to result in mechanical tension on cell-cell and cell-matrix interactions. Cell-cell and cellmatrix junctions provide tissue integrity, promote cell polarity, guarantee sufficient communication between cells to ensure synchronised milk secretion and support cell survival. Their disruption may be one of the early initiators of the mammary gland remodelling process. As a consequence, the primary goal of this study was to determine the potential effects of MEC stretch on changes in cell sensing within the mechanical micro-environment in the initiation of bovine MEC involution. During this investigation, particular emphasis was put on three potential mechanosensors: tight junctions (TJ), focal adhesions (FA) and primary cilia (PC), and their regulation in the early stages of involution using in vivo and in vitro experimental approaches. Static, biaxial in vitro cell stretch and acute physical distension in vivo resulted in changes in TJ protein expression levels implying a potential disruption of cell-cell communication as well as communication with the cell‟s cytoskeleton. Furthermore, down-regulation of Akt and pAkt following different periods of mechanical strain applied in vitro and decreased levels of pAkt following acute physical distension in vivo indicated a disruption of β1-integrin-FAK survival signalling through the PI3K-Akt pathway downstream of FA interactions. Increased numbers of ciliated MEC following extended periods of non-milking indicated a dedifferentiation of MEC. Furthermore, increased levels of STAT6 transcription (part of PC signalling following mechanical stimulation) factor indicates the initiation of macrophage accumulation and promotion of tissue remodelling of the bovine mammary gland. In conclusion, this study supports the hypothesis that local factors play an important role during bovine mammary gland involution and that mechanical stimulation may play a part in the initiation of this process.

Subjects/Keywords: Mammary glands; Epithelial cells; Bovine mammary glands

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APA (6^th Edition):

Biet, J. (2014). Effect of mechanical stress o the integrity, signalling mechanisms and function of bovine mammary epithelial cells : a thesis submitted in partial fulfilment of the requirements for the degree of Doctor of Philosophy in Animal Science at Massey University, Manawatū, Palmerston North, New Zealand . (Thesis). Massey University. Retrieved from http://hdl.handle.net/10179/7214

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Biet, Juliane. “Effect of mechanical stress o the integrity, signalling mechanisms and function of bovine mammary epithelial cells : a thesis submitted in partial fulfilment of the requirements for the degree of Doctor of Philosophy in Animal Science at Massey University, Manawatū, Palmerston North, New Zealand .” 2014. Thesis, Massey University. Accessed December 05, 2019. http://hdl.handle.net/10179/7214.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Biet, Juliane. “Effect of mechanical stress o the integrity, signalling mechanisms and function of bovine mammary epithelial cells : a thesis submitted in partial fulfilment of the requirements for the degree of Doctor of Philosophy in Animal Science at Massey University, Manawatū, Palmerston North, New Zealand .” 2014. Web. 05 Dec 2019.

Vancouver:

Biet J. Effect of mechanical stress o the integrity, signalling mechanisms and function of bovine mammary epithelial cells : a thesis submitted in partial fulfilment of the requirements for the degree of Doctor of Philosophy in Animal Science at Massey University, Manawatū, Palmerston North, New Zealand . [Internet] [Thesis]. Massey University; 2014. [cited 2019 Dec 05]. Available from: http://hdl.handle.net/10179/7214.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Biet J. Effect of mechanical stress o the integrity, signalling mechanisms and function of bovine mammary epithelial cells : a thesis submitted in partial fulfilment of the requirements for the degree of Doctor of Philosophy in Animal Science at Massey University, Manawatū, Palmerston North, New Zealand . [Thesis]. Massey University; 2014. Available from: http://hdl.handle.net/10179/7214

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Michigan State University

8. Dimenna, Gary Patrick. The regulation of fatty acid oxidation in bovine mammary tissue.

Degree: PhD, Department of Dairy Science and Institute of Nutrition, 1978, Michigan State University

URL: http://etd.lib.msu.edu/islandora/object/etd:42102

Subjects/Keywords: Fatty acid metabolism; Mammary glands; Cows

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APA (6^th Edition):

Dimenna, G. P. (1978). The regulation of fatty acid oxidation in bovine mammary tissue. (Doctoral Dissertation). Michigan State University. Retrieved from http://etd.lib.msu.edu/islandora/object/etd:42102

Chicago Manual of Style (16^th Edition):

Dimenna, Gary Patrick. “The regulation of fatty acid oxidation in bovine mammary tissue.” 1978. Doctoral Dissertation, Michigan State University. Accessed December 05, 2019. http://etd.lib.msu.edu/islandora/object/etd:42102.

MLA Handbook (7^th Edition):

Dimenna, Gary Patrick. “The regulation of fatty acid oxidation in bovine mammary tissue.” 1978. Web. 05 Dec 2019.

Vancouver:

Dimenna GP. The regulation of fatty acid oxidation in bovine mammary tissue. [Internet] [Doctoral dissertation]. Michigan State University; 1978. [cited 2019 Dec 05]. Available from: http://etd.lib.msu.edu/islandora/object/etd:42102.

Council of Science Editors:

Dimenna GP. The regulation of fatty acid oxidation in bovine mammary tissue. [Doctoral Dissertation]. Michigan State University; 1978. Available from: http://etd.lib.msu.edu/islandora/object/etd:42102

Swedish University of Agricultural Sciences

9. Fall, Nils. Health and reproduction in organic and conventional swedish dairy cows.

Degree: 2009, Swedish University of Agricultural Sciences

URL: http://pub.epsilon.slu.se/2069/

► This thesis compares indicators of animal health and reproduction in organically and conventionally managed dairy cows in Sweden. The first part of the thesis is… (more)

Subjects/Keywords: dairy cows; animal health; mammary glands; milk yield; animal performance; reproduction performance; metabolism; alternative agriculture; sweden; organic; dairy cow; udder health; milk yield; length of productive life; reproductive performance; metabolic profile

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APA (6^th Edition):

Fall, N. (2009). Health and reproduction in organic and conventional swedish dairy cows. (Doctoral Dissertation). Swedish University of Agricultural Sciences. Retrieved from http://pub.epsilon.slu.se/2069/

Chicago Manual of Style (16^th Edition):

Fall, Nils. “Health and reproduction in organic and conventional swedish dairy cows.” 2009. Doctoral Dissertation, Swedish University of Agricultural Sciences. Accessed December 05, 2019. http://pub.epsilon.slu.se/2069/.

MLA Handbook (7^th Edition):

Fall, Nils. “Health and reproduction in organic and conventional swedish dairy cows.” 2009. Web. 05 Dec 2019.

Vancouver:

Fall N. Health and reproduction in organic and conventional swedish dairy cows. [Internet] [Doctoral dissertation]. Swedish University of Agricultural Sciences; 2009. [cited 2019 Dec 05]. Available from: http://pub.epsilon.slu.se/2069/.

Council of Science Editors:

Fall N. Health and reproduction in organic and conventional swedish dairy cows. [Doctoral Dissertation]. Swedish University of Agricultural Sciences; 2009. Available from: http://pub.epsilon.slu.se/2069/

Michigan State University

10. Etchebarne, Brett Eric. IGF-I and leptin hormonal infusions alter the cell proliferation and transcriptional profile of the prepubertal bovine mammary gland.

Degree: PhD, Department of Animal Science, 2006, Michigan State University

URL: http://etd.lib.msu.edu/islandora/object/etd:34090

Subjects/Keywords: Cattle; Nutrition; Energy metabolism; Mammary glands; Epithelial cells

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APA (6^th Edition):

Etchebarne, B. E. (2006). IGF-I and leptin hormonal infusions alter the cell proliferation and transcriptional profile of the prepubertal bovine mammary gland. (Doctoral Dissertation). Michigan State University. Retrieved from http://etd.lib.msu.edu/islandora/object/etd:34090

Chicago Manual of Style (16^th Edition):

Etchebarne, Brett Eric. “IGF-I and leptin hormonal infusions alter the cell proliferation and transcriptional profile of the prepubertal bovine mammary gland.” 2006. Doctoral Dissertation, Michigan State University. Accessed December 05, 2019. http://etd.lib.msu.edu/islandora/object/etd:34090.

MLA Handbook (7^th Edition):

Etchebarne, Brett Eric. “IGF-I and leptin hormonal infusions alter the cell proliferation and transcriptional profile of the prepubertal bovine mammary gland.” 2006. Web. 05 Dec 2019.

Vancouver:

Etchebarne BE. IGF-I and leptin hormonal infusions alter the cell proliferation and transcriptional profile of the prepubertal bovine mammary gland. [Internet] [Doctoral dissertation]. Michigan State University; 2006. [cited 2019 Dec 05]. Available from: http://etd.lib.msu.edu/islandora/object/etd:34090.

Council of Science Editors:

Etchebarne BE. IGF-I and leptin hormonal infusions alter the cell proliferation and transcriptional profile of the prepubertal bovine mammary gland. [Doctoral Dissertation]. Michigan State University; 2006. Available from: http://etd.lib.msu.edu/islandora/object/etd:34090

11. Yonamine, Camila Miyagui. Clonagem de serino proteases do veneno da cascavel Crotalus durissus terrificus e expressão da giroxina em célula de mamífero.

Degree: Mestrado, Tecnologia Nuclear - Aplicações, 2007, University of São Paulo

URL: http://www.teses.usp.br/teses/disponiveis/85/85131/tde-16052012-081641/ ;

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As serino proteases participam de diversos processos fisiológicos (tal como o de coagulação) e patológicos. Essas enzimas estão amplamente distribuídas entre as espécies, são também… (more)

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As serino proteases participam de diversos processos fisiológicos (tal como o de coagulação) e patológicos. Essas enzimas estão amplamente distribuídas entre as espécies, são também toxinas dos venenos de serpentes, sendo denominadas SVSPs (snake venom serine proteases). Essas SVSPs são multifuncionais e contêm uma tríade catalítica formada pelos aminoácidos HDS. Algumas SVSPs são comercialmente disponíveis, sendo indicadas para o tratamento de infarto do miocárdio, tromboses e embolia pulmonar. No veneno de Crotalus durissus terrificus estão descritas até o momento, apenas duas SVSPs sendo que a mais estudada é a giroxina que representa cerca de 2,5% do veneno total. No presente estudo foi reportado a clonagem de sete serino proteases amplificadas a partir de uma biblioteca de cDNA de glândula de veneno de um único espécime adulto de Crotalus durissus terrificus. Estes clones foram analisados com relação à organização do cDNA, estrutura e prováveis funções. A construção do modelo tridimensional da giroxina permitiu verificar as similaridades com tripsina, trombina e outras SVSPs. A glicosilação e a presença de muitas pontes dissulfetos dificultam a obtenção das SVSP recombinantes na forma solúvel e com atividade, por expressão em E.coli. Assim, neste trabalho foi abordada a expressão em células de mamífero (que realiza as modificações pós-traducionais) com resultados promissores. Para tanto, o peptídeo sinal de Igk, a seqüência madura e a região 3 UTR da giroxina foram clonados no vetor pED, originando um novo vetor (pED-Giro). Este vetor carrega o peptídeo sinal de Igk, o que possibilitou a secreção da giroxina para o meio de cultura. O vetor pED-Giro foi transfectado em células CHO DXB11 dhfr e COS-7. A giroxina foi detectada no extrato total das células COS-7 por western blot e, em seguida, purificada do meio de cultura com coluna de afinidade (Benzamidina Sepharose) e demonstrado sua integridade pelo ensaio de atividade esterásica.

The serine proteases affect several physiological processes (such as the coagulation cascade) and pathological ones. These enzymes are widely distributed beyond the species; they are also toxins from snake venoms and are called SVSPs (snake venom serine proteases). These SVSPs are multifunctional and have a catalytic triad formed by HDS amino acids. Some of them are commercially available for use in clinical treatment for heart attack, tromboses and pulmonary embolism. So far, in Crotalus durissus terrificus venom only two SVSPs are described and gyroxin is considered the most studied SVSP which represents about 2,5% of the total venom. In the present study was reported the cloning of seven serine proteases amplified from a cDNA library of a venomous gland of a single adult specimen from Crotalus durissus terrificus venom. These clones have been analyzed in relation to the cDNA organization, structure and probable functions. The three-dimensional model of the gyroxin made possible the analysis of similarities with trypsin, thrombin and other SVSPs. The glycosylation and many…

Advisors/Committee Members: Camillo, Maria Aparecida Pires.

Subjects/Keywords: animal cells; clonagem; cloning; Crotalus; enzyme; escherica coli; expressão; giroxina; mammary glands; serine proteinases; serino proteases; snakes; thrombin; trypsin; venoms

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Yonamine, C. M. (2007). Clonagem de serino proteases do veneno da cascavel Crotalus durissus terrificus e expressão da giroxina em célula de mamífero. (Masters Thesis). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/85/85131/tde-16052012-081641/ ;

Chicago Manual of Style (16^th Edition):

Yonamine, Camila Miyagui. “Clonagem de serino proteases do veneno da cascavel Crotalus durissus terrificus e expressão da giroxina em célula de mamífero.” 2007. Masters Thesis, University of São Paulo. Accessed December 05, 2019. http://www.teses.usp.br/teses/disponiveis/85/85131/tde-16052012-081641/ ;.

MLA Handbook (7^th Edition):

Yonamine, Camila Miyagui. “Clonagem de serino proteases do veneno da cascavel Crotalus durissus terrificus e expressão da giroxina em célula de mamífero.” 2007. Web. 05 Dec 2019.

Vancouver:

Yonamine CM. Clonagem de serino proteases do veneno da cascavel Crotalus durissus terrificus e expressão da giroxina em célula de mamífero. [Internet] [Masters thesis]. University of São Paulo; 2007. [cited 2019 Dec 05]. Available from: http://www.teses.usp.br/teses/disponiveis/85/85131/tde-16052012-081641/ ;.

Council of Science Editors:

Yonamine CM. Clonagem de serino proteases do veneno da cascavel Crotalus durissus terrificus e expressão da giroxina em célula de mamífero. [Masters Thesis]. University of São Paulo; 2007. Available from: http://www.teses.usp.br/teses/disponiveis/85/85131/tde-16052012-081641/ ;

Rutgers University

12. Butler, Kristie Lynn, 1989-. Role of Bcl-2 proteins in stress-induced apoptosis in a non-transformed mammary epithelial cell line.

Degree: MS, Microbiology and Molecular Genetics, 2014, Rutgers University

URL: https://rucore.libraries.rutgers.edu/rutgers-lib/44023/

► Apoptosis is the process of programmed cell death characterized by morphological and physiological changes executed by cells in response to a stimulus. The apoptotic process… (more)

▼ Apoptosis is the process of programmed cell death characterized by morphological and physiological changes executed by cells in response to a stimulus. The apoptotic process contributes to the loss of milk secreting cells (i.e. mammary epithelial cells) that occurs in the bovine mammary gland once peak lactation has occurred. However, the specific mechanisms by which this occurs are unknown. The goal of this work was to examine the role of the Bcl-2 family of proteins in regulating apoptosis in the bovine mammary epithelial cell line, MAC-T. The Bcl-2 family is divided into three categories based on protein function and combinations of four Bcl-2 homology (BH) domains. Anti-apoptotic multidomain proteins, such as Bcl-2 and Mcl-1, prevent apoptosis by binding to pro-apoptotic members of the family. Pro-apoptotic multidomain proteins, such as Bax, help to regulate apoptosis at the mitochondrial outer membrane. Pro-apoptotic BH3-only proteins, such as Bad and Bim, act as messengers between the anti-apoptotic and pro-apoptotic proteins. To investigate the roles of Bcl-2 proteins in apoptosis, MAC-T cells were treated with anisomycin (ANS), an activator of the intrinsic apoptotic pathway. ANS had little effect on Bcl-2 or Bax mRNA levels while it induced a 40 to 60% decrease in levels of Bad mRNA. Protein expression of Bax did not change during apoptosis, while Bcl-2, Mcl-1, and Bad expression decreased to varying degrees. The greatest change in protein levels was observed for Mcl-1, whose expression was nearly non-detectable after 4 h of treatment with ANS. Bim was phosphorylated in response to ANS but this was not caused by JNK or p38 signaling. Knock-down of Bim using siRNA decreased the ability of ANS to induce apoptosis. Mcl-1 and Bim protein expression changed in a similar time frame, therefore, interactions between the two proteins were evaluated using co-immunoprecipitation experiments. Mcl-1 and Bim interacted both basally and after treatment with ANS. The significance of Bim phosphorylation, the kinase responsible for its phosphorylation, and the functional significance of the interaction between Bim and Mcl-1 in stress-induced apoptosis remain to be determined. Advisors/Committee Members: Cohick, Wendie (chair), Belden, William (internal member), Di, Rong (internal member).

Subjects/Keywords: Apoptosis; Mammary glands – Secretions; Proteins – Affinity labeling

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Butler, Kristie Lynn, 1. (2014). Role of Bcl-2 proteins in stress-induced apoptosis in a non-transformed mammary epithelial cell line. (Masters Thesis). Rutgers University. Retrieved from https://rucore.libraries.rutgers.edu/rutgers-lib/44023/

Chicago Manual of Style (16^th Edition):

Butler, Kristie Lynn, 1989-. “Role of Bcl-2 proteins in stress-induced apoptosis in a non-transformed mammary epithelial cell line.” 2014. Masters Thesis, Rutgers University. Accessed December 05, 2019. https://rucore.libraries.rutgers.edu/rutgers-lib/44023/.

MLA Handbook (7^th Edition):

Butler, Kristie Lynn, 1989-. “Role of Bcl-2 proteins in stress-induced apoptosis in a non-transformed mammary epithelial cell line.” 2014. Web. 05 Dec 2019.

Vancouver:

Butler, Kristie Lynn 1. Role of Bcl-2 proteins in stress-induced apoptosis in a non-transformed mammary epithelial cell line. [Internet] [Masters thesis]. Rutgers University; 2014. [cited 2019 Dec 05]. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/44023/.

Council of Science Editors:

Butler, Kristie Lynn 1. Role of Bcl-2 proteins in stress-induced apoptosis in a non-transformed mammary epithelial cell line. [Masters Thesis]. Rutgers University; 2014. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/44023/

Michigan State University

13. Kuo, Chao-Hen. The purification and characterization of [beta]-galactosidase from rat mammary gland.

Degree: MS, 1976, Michigan State University

URL: http://etd.lib.msu.edu/islandora/object/etd:11956

Subjects/Keywords: Mammary glands; Rats

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Kuo, C. (1976). The purification and characterization of [beta]-galactosidase from rat mammary gland. (Masters Thesis). Michigan State University. Retrieved from http://etd.lib.msu.edu/islandora/object/etd:11956

Chicago Manual of Style (16^th Edition):

Kuo, Chao-Hen. “The purification and characterization of [beta]-galactosidase from rat mammary gland.” 1976. Masters Thesis, Michigan State University. Accessed December 05, 2019. http://etd.lib.msu.edu/islandora/object/etd:11956.

MLA Handbook (7^th Edition):

Kuo, Chao-Hen. “The purification and characterization of [beta]-galactosidase from rat mammary gland.” 1976. Web. 05 Dec 2019.

Vancouver:

Kuo C. The purification and characterization of [beta]-galactosidase from rat mammary gland. [Internet] [Masters thesis]. Michigan State University; 1976. [cited 2019 Dec 05]. Available from: http://etd.lib.msu.edu/islandora/object/etd:11956.

Council of Science Editors:

Kuo C. The purification and characterization of [beta]-galactosidase from rat mammary gland. [Masters Thesis]. Michigan State University; 1976. Available from: http://etd.lib.msu.edu/islandora/object/etd:11956

Michigan State University

14. Sinha, Yagya Nand. The normal mammary gland development of rats 10 to 100 days of age.

Degree: MS, Dept. of Dairy, 1964, Michigan State University

URL: http://etd.lib.msu.edu/islandora/object/etd:13067

Subjects/Keywords: Mammary glands; Rats

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Sinha, Y. N. (1964). The normal mammary gland development of rats 10 to 100 days of age. (Masters Thesis). Michigan State University. Retrieved from http://etd.lib.msu.edu/islandora/object/etd:13067

Chicago Manual of Style (16^th Edition):

Sinha, Yagya Nand. “The normal mammary gland development of rats 10 to 100 days of age.” 1964. Masters Thesis, Michigan State University. Accessed December 05, 2019. http://etd.lib.msu.edu/islandora/object/etd:13067.

MLA Handbook (7^th Edition):

Sinha, Yagya Nand. “The normal mammary gland development of rats 10 to 100 days of age.” 1964. Web. 05 Dec 2019.

Vancouver:

Sinha YN. The normal mammary gland development of rats 10 to 100 days of age. [Internet] [Masters thesis]. Michigan State University; 1964. [cited 2019 Dec 05]. Available from: http://etd.lib.msu.edu/islandora/object/etd:13067.

Council of Science Editors:

Sinha YN. The normal mammary gland development of rats 10 to 100 days of age. [Masters Thesis]. Michigan State University; 1964. Available from: http://etd.lib.msu.edu/islandora/object/etd:13067

Michigan State University

15. Steyert, Donald Harrison, 1940-. Purification of a steroid binding protein in mammary gland.

Degree: PhD, Department of Dairy, 1971, Michigan State University

URL: http://etd.lib.msu.edu/islandora/object/etd:35867

Subjects/Keywords: Mammary glands; Proteins

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Steyert, Donald Harrison, 1. (1971). Purification of a steroid binding protein in mammary gland. (Doctoral Dissertation). Michigan State University. Retrieved from http://etd.lib.msu.edu/islandora/object/etd:35867

Chicago Manual of Style (16^th Edition):

Steyert, Donald Harrison, 1940-. “Purification of a steroid binding protein in mammary gland.” 1971. Doctoral Dissertation, Michigan State University. Accessed December 05, 2019. http://etd.lib.msu.edu/islandora/object/etd:35867.

MLA Handbook (7^th Edition):

Steyert, Donald Harrison, 1940-. “Purification of a steroid binding protein in mammary gland.” 1971. Web. 05 Dec 2019.

Vancouver:

Steyert, Donald Harrison 1. Purification of a steroid binding protein in mammary gland. [Internet] [Doctoral dissertation]. Michigan State University; 1971. [cited 2019 Dec 05]. Available from: http://etd.lib.msu.edu/islandora/object/etd:35867.

Council of Science Editors:

Steyert, Donald Harrison 1. Purification of a steroid binding protein in mammary gland. [Doctoral Dissertation]. Michigan State University; 1971. Available from: http://etd.lib.msu.edu/islandora/object/etd:35867

Michigan State University

16. Johnston, Raymond Frank. The effects of estrogen on mammary structure of adrenalectomized and thiouracil treated castrate rats.

Degree: MS, 1948, Michigan State University

URL: http://etd.lib.msu.edu/islandora/object/etd:15648

Subjects/Keywords: Estrogen; Mammary glands

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Johnston, R. F. (1948). The effects of estrogen on mammary structure of adrenalectomized and thiouracil treated castrate rats. (Masters Thesis). Michigan State University. Retrieved from http://etd.lib.msu.edu/islandora/object/etd:15648

Chicago Manual of Style (16^th Edition):

Johnston, Raymond Frank. “The effects of estrogen on mammary structure of adrenalectomized and thiouracil treated castrate rats.” 1948. Masters Thesis, Michigan State University. Accessed December 05, 2019. http://etd.lib.msu.edu/islandora/object/etd:15648.

MLA Handbook (7^th Edition):

Johnston, Raymond Frank. “The effects of estrogen on mammary structure of adrenalectomized and thiouracil treated castrate rats.” 1948. Web. 05 Dec 2019.

Vancouver:

Johnston RF. The effects of estrogen on mammary structure of adrenalectomized and thiouracil treated castrate rats. [Internet] [Masters thesis]. Michigan State University; 1948. [cited 2019 Dec 05]. Available from: http://etd.lib.msu.edu/islandora/object/etd:15648.

Council of Science Editors:

Johnston RF. The effects of estrogen on mammary structure of adrenalectomized and thiouracil treated castrate rats. [Masters Thesis]. Michigan State University; 1948. Available from: http://etd.lib.msu.edu/islandora/object/etd:15648

Michigan State University

17. Gupta, Bhola Nath, 1937-. Physical and chemical response of mammary gland to endotoxin.

Degree: PhD, Department of Pathology, 1971, Michigan State University

URL: http://etd.lib.msu.edu/islandora/object/etd:40627

Subjects/Keywords: Mammary glands; Endotoxins

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APA (6^th Edition):

Gupta, Bhola Nath, 1. (1971). Physical and chemical response of mammary gland to endotoxin. (Doctoral Dissertation). Michigan State University. Retrieved from http://etd.lib.msu.edu/islandora/object/etd:40627

Chicago Manual of Style (16^th Edition):

Gupta, Bhola Nath, 1937-. “Physical and chemical response of mammary gland to endotoxin.” 1971. Doctoral Dissertation, Michigan State University. Accessed December 05, 2019. http://etd.lib.msu.edu/islandora/object/etd:40627.

MLA Handbook (7^th Edition):

Gupta, Bhola Nath, 1937-. “Physical and chemical response of mammary gland to endotoxin.” 1971. Web. 05 Dec 2019.

Vancouver:

Gupta, Bhola Nath 1. Physical and chemical response of mammary gland to endotoxin. [Internet] [Doctoral dissertation]. Michigan State University; 1971. [cited 2019 Dec 05]. Available from: http://etd.lib.msu.edu/islandora/object/etd:40627.

Council of Science Editors:

Gupta, Bhola Nath 1. Physical and chemical response of mammary gland to endotoxin. [Doctoral Dissertation]. Michigan State University; 1971. Available from: http://etd.lib.msu.edu/islandora/object/etd:40627

18. Polter, Abigail Marie. Regulation of GSK3 in the pathophysiology and treatment of mood disorders.

Degree: PhD, 2010, University of Alabama – Birmingham

URL: http://contentdm.mhsl.uab.edu/u?/etd,1108

►

Mood disorders are devastating psychiatric illnesses that will affect as many as one in every five persons worldwide over the course of their lifetime. Significant… (more)

▼

Mood disorders are devastating psychiatric illnesses that will affect as many as one in every five persons worldwide over the course of their lifetime. Significant gaps still remain in our understanding of these illnesses and outcomes for many patients are far from optimal. Glycogen Synthase Kinase 3 (GSK3) is a protein kinase that is increasingly recognized as playing an important role in a number of neuronal functions, as well as in pathological states such as mood disorders. GSK3 is inhibited in the brain by phosphorylation on an N-terminal serine. Several treatments for mood disorders, including lithium, antidepressants, and atypical antipsychotics increase this inhibitory phosphorylation, suggesting that it may be an important mechanism for the regulation of mood. In these studies, we investigate the role of serine phosphorylation of GSK3 in the treatment and pathophysiology of mood disorders. To investigate the mechanisms of mood disorder treatment, we first examined activation of Akt, an upstream regulating kinase of GSK3, in response to serotonin. Both an acute increase in serotonin and chronic antidepressant treatment result in a functional activation of the Akt signaling pathway. Similarly, activation of 5-HT1A receptors were found to increase phosphorylation of GSK3 through activation of the PI3K/Akt pathway, and phosphorylation of GSK3 was found to be necessary for 5-HT1A receptor-mediated inhibition of conditioned fear memories. Antagonism of 5-HT2A receptors was found to inhibit GSK3 through activation of Akt, while activation of 5-HT2A receptors was found to increase inhibitory phosphorylation of GSK3 only in the absence of β-arrestin2. Furthermore, loss of β-arrestin2 potentiates the antidepressant-induced increase in phosphorylated GSK3 as well as the behavioral response to antidepressants. Finally, we investigated the behavioral effects of decreased serine-phosphorylation of GSK3 using knock-in mice with GSK3 that is immune to serine phosphorylation. We found that loss of this phosphorylation resulted in increased behavioral susceptibility to induction of both manic- and depressive-like states. The studies presented here demonstrate that serine phosphorylation of GSK3 plays a critical role in mood disorder pathology. This gives us novel insights into the regulation of mood, and may provide avenues for the development of more effective treatments for mood disorders.

1 online resource (x, 250 p.) : ill., digital, PDF file.

Neurobiology;

Joint Health Sciences;

GSK3 Akt Mood Disorders Serotonin Antidepressants Behavior

UNRESTRICTED

Advisors/Committee Members: Li. Xiaohua, Hablitz, John , Jope, Richard , Theibert, Anne , Wilson, Scott.

Subjects/Keywords: Behavior, Animal – physiology<; br>; Brain – metabolism<; br>; Exploratory Behavior – physiology<; br>; Forkhead Transcription Factors – metabolism<; br>; Glycogen Synthase Kinase 3<; br>; Mood Disorders<; br>; Receptor, Serotonin, 5-HT1A – metabolism<; br>; Serine – metabolism<; br>; Serotonin – metabolism<; br>; Signal Transduction

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Polter, A. M. (2010). Regulation of GSK3 in the pathophysiology and treatment of mood disorders. (Doctoral Dissertation). University of Alabama – Birmingham. Retrieved from http://contentdm.mhsl.uab.edu/u?/etd,1108

Chicago Manual of Style (16^th Edition):

Polter, Abigail Marie. “Regulation of GSK3 in the pathophysiology and treatment of mood disorders.” 2010. Doctoral Dissertation, University of Alabama – Birmingham. Accessed December 05, 2019. http://contentdm.mhsl.uab.edu/u?/etd,1108.

MLA Handbook (7^th Edition):

Polter, Abigail Marie. “Regulation of GSK3 in the pathophysiology and treatment of mood disorders.” 2010. Web. 05 Dec 2019.

Vancouver:

Polter AM. Regulation of GSK3 in the pathophysiology and treatment of mood disorders. [Internet] [Doctoral dissertation]. University of Alabama – Birmingham; 2010. [cited 2019 Dec 05]. Available from: http://contentdm.mhsl.uab.edu/u?/etd,1108.

Council of Science Editors:

Polter AM. Regulation of GSK3 in the pathophysiology and treatment of mood disorders. [Doctoral Dissertation]. University of Alabama – Birmingham; 2010. Available from: http://contentdm.mhsl.uab.edu/u?/etd,1108

19. Almeida, Omer Cavalcanti de. Concentração arterial, retenção de metabólitos pela glândula mamária e concentração de CLA no leite de cabras, em resposta à ingestão de fontes de ácidos graxos poliinsaturados ou doses crescentes de óleo de soja.

Degree: PhD, Ciência Animal e Pastagens, 2008, University of São Paulo

URL: http://www.teses.usp.br/teses/disponiveis/11/11139/tde-25072008-103027/ ;

► Os objetivos dos experimentos (I e II) foram avaliar os efeitos da inclusão de 2% de fontes de ácidos graxos poliinsaturados (óleo de soja, de… (more)

▼ Os objetivos dos experimentos (I e II) foram avaliar os efeitos da inclusão de 2% de fontes de ácidos graxos poliinsaturados (óleo de soja, de linhaça e de peixe) e doses crescentes de óleo de soja (0, 30, 60 e 90 g/dia) sobre o consumo, digestibilidade dos nutrientes no trato digestório total, produção e composição do leite, perfil de ácidos graxos arterial e no leite, concentração arterial e retenção de metabólitos pela glândula mamária das cabras em lactação. Dois meses antes do início do experimento, os animais foram preparados cirurgicamente para exteriorização subcutânea de ambas as artérias carótidas a fim de facilitar a colheita do sangue arterial. Os animais foram alojados em baias individuais onde receberam ração com 40% de silagem de milho e 60% de concentrado, com base na matéria seca. No experimento 1, foram utilizadas quatro cabras Saanen multíparas, produzindo 2,4 kg/dia e com 35 dias de lactação e foram distribuídas em Quadrado Latino 4 x 4 com período experimental de 112 dias. Cada subperíodo teve a duração de 24 dias de adaptação e 4 dias de colheita. Os tratamentos do experimento I foram: a) ração sem adição de óleo (controle); b) controle mais 2% de óleo de soja (OS); c) controle mais 2% de óleo de linhaça (OL) e d) controle mais 2% de óleo de peixe (OP). No experimento 2, foram utilizadas quatro cabras Saanen multíparas, produzindo 3,7 kg/dia e com 35 dias de lactação e foram distribuídas em Quadrado Latino 4 x 4 com período experimental de 112 dias. Cada período teve a duração de 24 dias de adaptação e 4 dias de colheita. Os tratamentos do experimento 2 foram: Ração controle mais o fornecimento oral de doses de óleo de soja (0, 30, 60 e 90 g). No experimento l, a inclusão dos óleos não influenciou o consumo da matéria seca (CMS), da matéria orgânica (CMO), da fibra em detergente neutro (CFDN) e da proteína bruta (CPB), embora tenha havido efeito quando o CMS e o de CMO foram relacionados com o peso metabólico. O CEE foi influenciado pelos óleos. As digestibilidades da MS, MO, FDN, PB e do EE no trato digestório total não foram influenciadas. Não houve efeito na produção de leite e nos seus componentes (gordura, proteína, lactose, sólidos totais e extrato seco desengordurado), embora tenha havido efeito no perfil de ácidos graxos. O óleo de peixe promoveu elevação (350%) na concentração do ácido vacênico (C18:1 t11) no leite, alem de maiores elevações na concentração arterial do ácido vacênico (376%) e na relação C18:1 t11, C18:2 c9, t11 (1111%). A adição dos óleos nas rações, não influenciou a concentração arterial e a retenção de metabólitos (glicose, ß- hidroxibutirato) pela glândula mamária. No experimento 2, as doses de óleo de soja alteraram o CMS e o CMO, assim como a digestibilidade da MS e do EE. Não houve efeito na produção de leite, porém a concentração de gordura diminuiu com as doses de óleo. Os perfis de ácidos graxos no leite e no sangue arterial foram influenciados pelas doses de óleo de soja. O aparecimento do C18:2 t10, c12 no leite culminou com a redução de gordura (558%). A… Advisors/Committee Members: Pires, Alexandre Vaz.

Subjects/Keywords: Ácidos graxos; Caprinos leiteiros; CLA; Digestibilidade; Fatty acids; Glândulas mamárias de animal - Metabolismo; Goats.; Lactação animal; Leite.; Lipids supply; Mammary metabolism

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APA (6^th Edition):

Almeida, O. C. d. (2008). Concentração arterial, retenção de metabólitos pela glândula mamária e concentração de CLA no leite de cabras, em resposta à ingestão de fontes de ácidos graxos poliinsaturados ou doses crescentes de óleo de soja. (Doctoral Dissertation). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/11/11139/tde-25072008-103027/ ;

Chicago Manual of Style (16^th Edition):

Almeida, Omer Cavalcanti de. “Concentração arterial, retenção de metabólitos pela glândula mamária e concentração de CLA no leite de cabras, em resposta à ingestão de fontes de ácidos graxos poliinsaturados ou doses crescentes de óleo de soja.” 2008. Doctoral Dissertation, University of São Paulo. Accessed December 05, 2019. http://www.teses.usp.br/teses/disponiveis/11/11139/tde-25072008-103027/ ;.

MLA Handbook (7^th Edition):

Almeida, Omer Cavalcanti de. “Concentração arterial, retenção de metabólitos pela glândula mamária e concentração de CLA no leite de cabras, em resposta à ingestão de fontes de ácidos graxos poliinsaturados ou doses crescentes de óleo de soja.” 2008. Web. 05 Dec 2019.

Vancouver:

Almeida OCd. Concentração arterial, retenção de metabólitos pela glândula mamária e concentração de CLA no leite de cabras, em resposta à ingestão de fontes de ácidos graxos poliinsaturados ou doses crescentes de óleo de soja. [Internet] [Doctoral dissertation]. University of São Paulo; 2008. [cited 2019 Dec 05]. Available from: http://www.teses.usp.br/teses/disponiveis/11/11139/tde-25072008-103027/ ;.

Council of Science Editors:

Almeida OCd. Concentração arterial, retenção de metabólitos pela glândula mamária e concentração de CLA no leite de cabras, em resposta à ingestão de fontes de ácidos graxos poliinsaturados ou doses crescentes de óleo de soja. [Doctoral Dissertation]. University of São Paulo; 2008. Available from: http://www.teses.usp.br/teses/disponiveis/11/11139/tde-25072008-103027/ ;

University of Florida

20. Johnson, Amber. Prenatal Androgen and Estrogen Signaling in the Sexually Dimorphic Development of the Mammary Glands.

Degree: 2014, University of Florida

URL: http://ufdc.ufl.edu/AA00059449

► Mammary gland development begins prenatally in both male and female mice, but adult male mice do not have nipples or mammary glands. In society today,… (more)

Subjects/Keywords: Adults; Androgen receptors; Androgens; Estrogen receptors; Estrogens; Mammary development; Mammary glands; Masculinity; Nipples; Women; Androgens; Estrogen; Mammary glands; Mice

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Johnson, A. (2014). Prenatal Androgen and Estrogen Signaling in the Sexually Dimorphic Development of the Mammary Glands. (Thesis). University of Florida. Retrieved from http://ufdc.ufl.edu/AA00059449

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Johnson, Amber. “Prenatal Androgen and Estrogen Signaling in the Sexually Dimorphic Development of the Mammary Glands.” 2014. Thesis, University of Florida. Accessed December 05, 2019. http://ufdc.ufl.edu/AA00059449.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Johnson, Amber. “Prenatal Androgen and Estrogen Signaling in the Sexually Dimorphic Development of the Mammary Glands.” 2014. Web. 05 Dec 2019.

Vancouver:

Johnson A. Prenatal Androgen and Estrogen Signaling in the Sexually Dimorphic Development of the Mammary Glands. [Internet] [Thesis]. University of Florida; 2014. [cited 2019 Dec 05]. Available from: http://ufdc.ufl.edu/AA00059449.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Johnson A. Prenatal Androgen and Estrogen Signaling in the Sexually Dimorphic Development of the Mammary Glands. [Thesis]. University of Florida; 2014. Available from: http://ufdc.ufl.edu/AA00059449

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

21. Babinszky, L. Energy metabolism and lactation performance of primiparous sows as affected by dietary fat and vitamin E.

Degree: 1992, Agricultural University

URL: http://library.wur.nl/WebQuery/wurpubs/18217 ; urn:nbn:nl:ui:32-18217 ; urn:nbn:nl:ui:32-18217 ; http://library.wur.nl/WebQuery/wurpubs/18217

► In this thesis different levels of dietary fat (37, 43, 75 and 125 g/kg DM, respectively) and vitamin E (from 14 to 151 mg… (more)

Subjects/Keywords: metabolisme; voer; zeugen; varkens; vrouwelijke dieren; melkklieren; melksecretie; lactatie; diervoedering; Fysiologie van de diervoeding; metabolism; feeds; sows; pigs; female animals; mammary glands; milk secretion; lactation; animal feeding; Animal Nutrition Physiology

Record Details Similar Records Cite « Share

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Babinszky, L. (1992). Energy metabolism and lactation performance of primiparous sows as affected by dietary fat and vitamin E. (Doctoral Dissertation). Agricultural University. Retrieved from http://library.wur.nl/WebQuery/wurpubs/18217 ; urn:nbn:nl:ui:32-18217 ; urn:nbn:nl:ui:32-18217 ; http://library.wur.nl/WebQuery/wurpubs/18217

Chicago Manual of Style (16^th Edition):

Babinszky, L. “Energy metabolism and lactation performance of primiparous sows as affected by dietary fat and vitamin E.” 1992. Doctoral Dissertation, Agricultural University. Accessed December 05, 2019. http://library.wur.nl/WebQuery/wurpubs/18217 ; urn:nbn:nl:ui:32-18217 ; urn:nbn:nl:ui:32-18217 ; http://library.wur.nl/WebQuery/wurpubs/18217.

MLA Handbook (7^th Edition):

Babinszky, L. “Energy metabolism and lactation performance of primiparous sows as affected by dietary fat and vitamin E.” 1992. Web. 05 Dec 2019.

Vancouver:

Babinszky L. Energy metabolism and lactation performance of primiparous sows as affected by dietary fat and vitamin E. [Internet] [Doctoral dissertation]. Agricultural University; 1992. [cited 2019 Dec 05]. Available from: http://library.wur.nl/WebQuery/wurpubs/18217 ; urn:nbn:nl:ui:32-18217 ; urn:nbn:nl:ui:32-18217 ; http://library.wur.nl/WebQuery/wurpubs/18217.

Council of Science Editors:

Babinszky L. Energy metabolism and lactation performance of primiparous sows as affected by dietary fat and vitamin E. [Doctoral Dissertation]. Agricultural University; 1992. Available from: http://library.wur.nl/WebQuery/wurpubs/18217 ; urn:nbn:nl:ui:32-18217 ; urn:nbn:nl:ui:32-18217 ; http://library.wur.nl/WebQuery/wurpubs/18217

University of Florida

22. Kensinger, Ronald Scott, 1953-. Studies on conceptus hormone production during the period of mammogenesis and lactogenesis in the cow (Bos taurus) and pig (Sus scrofa).

Degree: 1982, University of Florida

URL: http://ufdc.ufl.edu/AA00026568

Subjects/Keywords: Acetates; DNA; Estrogens; Gilts; Hormones; Lactation; Mammary development; Mammary glands; Milk synthesis; Pregnancy; Animal Science thesis Ph. D; Cattle – Reproduction; Lactation; Mammary glands; Swine – Reproduction

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Kensinger, Ronald Scott, 1. (1982). Studies on conceptus hormone production during the period of mammogenesis and lactogenesis in the cow (Bos taurus) and pig (Sus scrofa). (Thesis). University of Florida. Retrieved from http://ufdc.ufl.edu/AA00026568

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Kensinger, Ronald Scott, 1953-. “Studies on conceptus hormone production during the period of mammogenesis and lactogenesis in the cow (Bos taurus) and pig (Sus scrofa).” 1982. Thesis, University of Florida. Accessed December 05, 2019. http://ufdc.ufl.edu/AA00026568.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Kensinger, Ronald Scott, 1953-. “Studies on conceptus hormone production during the period of mammogenesis and lactogenesis in the cow (Bos taurus) and pig (Sus scrofa).” 1982. Web. 05 Dec 2019.

Vancouver:

Kensinger, Ronald Scott 1. Studies on conceptus hormone production during the period of mammogenesis and lactogenesis in the cow (Bos taurus) and pig (Sus scrofa). [Internet] [Thesis]. University of Florida; 1982. [cited 2019 Dec 05]. Available from: http://ufdc.ufl.edu/AA00026568.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Kensinger, Ronald Scott 1. Studies on conceptus hormone production during the period of mammogenesis and lactogenesis in the cow (Bos taurus) and pig (Sus scrofa). [Thesis]. University of Florida; 1982. Available from: http://ufdc.ufl.edu/AA00026568

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

23. Machamer, James Brian. Lim Kinase 1 And Twinstar In Synaptic Plasticity Of Drosophila Motoneurons.

Degree: PhD, 2010, University of Alabama – Birmingham

URL: http://contentdm.mhsl.uab.edu/u?/etd,1429

►

Modification of the actin cytoskeleton is essential for synaptic plasticity, which is believed to underlie the brain's capacity for learning and memory. Regulation of the… (more)

▼

Modification of the actin cytoskeleton is essential for synaptic plasticity, which is believed to underlie the brain's capacity for learning and memory. Regulation of the actin cytoskeleton by LIM Kinases (LIMK1 and LIMK2) and their downstream targets Actin Depolymerization Factor/Cofilin (ADF/Cofilin) in the mouse forebrain modulates dendritic spine morphology, synaptic function, long-term potentiation (LTP), and learning and memory, but appear dispensable for the regulation of most forms of presynaptic plasticity. However, these analyses were performed in mice mutant for single members of these gene families, and thus the interpretation of these results is confounded by potential compensatory activity of homologous genes. The objective of this study is to characterize the role of the single Drosophila homolog of the LIMK family (dLIMK1) and the single neuronally-expressed Drosophila homolog of ADF/Cofilin (Twinstar; Tsr) in morphological and functional plasticity of motoneurons. Additionally, we wish to investigate the actin-based cellular mechanisms that contribute to these forms of synaptic plasticity. We found that dLIMK1 acts via Tsr to restrain synaptic growth in the presynaptic terminal, especially by restraining the formation of immature branching boutons. Functionally, we found that Tsr activity is important for the proper Ca²⁺-cooperativity of vesicle fusion and normal paired-pulse facilitation (PPF), and that both dLIMK1 and Tsr are required for proper tetanus-induced potentiation (TIP). Furthermore, both dLIMK1 mutants and tsr mutants displayed synaptic depression. These results demonstrate that dLIMK1 and Tsr modulate developmentally-regulated morphological and activity-dependent functional plasticity of Drosophila motoneurons and illustrate the conservation of mechanisms regulating neuronal branching between postsynaptic excitatory neurons in mice and presynaptic motoneurons in Drosophila. These results suggest that the lack of alterations in presynaptic forms of plasticity in mice mutant for LIMK1 or non-muscle cofilin (n-Cof) is a consequence of compensation by LIMK2 and ADF, respectively.

PhD

1 online resource (xix, 151 p.) :ill., digital, PDF file.

Cell Biology

Joint Health Sciences

actin ADF/Cofilin bouton Drosophila LIM Kinase NMJ

UNRESTRICTED

Subjects/Keywords: alpha-Crystallin A Chain – metabolism.<; br>; Cataract – metabolism.<; br>; Disease Models, Animal<; br>; Lens, Crystalline – metabolism<; br>; Peptide Fragments – metabolism<; br>; Singlet Oxygen.

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Machamer, J. B. (2010). Lim Kinase 1 And Twinstar In Synaptic Plasticity Of Drosophila Motoneurons. (Doctoral Dissertation). University of Alabama – Birmingham. Retrieved from http://contentdm.mhsl.uab.edu/u?/etd,1429

Chicago Manual of Style (16^th Edition):

Machamer, James Brian. “Lim Kinase 1 And Twinstar In Synaptic Plasticity Of Drosophila Motoneurons.” 2010. Doctoral Dissertation, University of Alabama – Birmingham. Accessed December 05, 2019. http://contentdm.mhsl.uab.edu/u?/etd,1429.

MLA Handbook (7^th Edition):

Machamer, James Brian. “Lim Kinase 1 And Twinstar In Synaptic Plasticity Of Drosophila Motoneurons.” 2010. Web. 05 Dec 2019.

Vancouver:

Machamer JB. Lim Kinase 1 And Twinstar In Synaptic Plasticity Of Drosophila Motoneurons. [Internet] [Doctoral dissertation]. University of Alabama – Birmingham; 2010. [cited 2019 Dec 05]. Available from: http://contentdm.mhsl.uab.edu/u?/etd,1429.

Council of Science Editors:

Machamer JB. Lim Kinase 1 And Twinstar In Synaptic Plasticity Of Drosophila Motoneurons. [Doctoral Dissertation]. University of Alabama – Birmingham; 2010. Available from: http://contentdm.mhsl.uab.edu/u?/etd,1429

Texas A&M University

24. Marich, James Edward. The chromatin structure of endogenous MTV proviruses in Mus musculus.

Degree: MS, biochemistry, 2012, Texas A&M University

URL: http://hdl.handle.net/1969.1/ETD-TAMU-1985-THESIS-M333

Subjects/Keywords: biochemistry.; Major biochemistry.; Breast - Cancer - Animal models.; Mammary glands - Tumors.; Mice - Diseases.

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Marich, J. E. (2012). The chromatin structure of endogenous MTV proviruses in Mus musculus. (Masters Thesis). Texas A&M University. Retrieved from http://hdl.handle.net/1969.1/ETD-TAMU-1985-THESIS-M333

Chicago Manual of Style (16^th Edition):

Marich, James Edward. “The chromatin structure of endogenous MTV proviruses in Mus musculus.” 2012. Masters Thesis, Texas A&M University. Accessed December 05, 2019. http://hdl.handle.net/1969.1/ETD-TAMU-1985-THESIS-M333.

MLA Handbook (7^th Edition):

Marich, James Edward. “The chromatin structure of endogenous MTV proviruses in Mus musculus.” 2012. Web. 05 Dec 2019.

Vancouver:

Marich JE. The chromatin structure of endogenous MTV proviruses in Mus musculus. [Internet] [Masters thesis]. Texas A&M University; 2012. [cited 2019 Dec 05]. Available from: http://hdl.handle.net/1969.1/ETD-TAMU-1985-THESIS-M333.

Council of Science Editors:

Marich JE. The chromatin structure of endogenous MTV proviruses in Mus musculus. [Masters Thesis]. Texas A&M University; 2012. Available from: http://hdl.handle.net/1969.1/ETD-TAMU-1985-THESIS-M333

Iowa State University

25. Ferreri, Laurance Faye. Experimental lactogenesis: Role of pituitary, adrenal, and ovarian hormones in initiating milk secretion in rats.

Degree: 1971, Iowa State University

URL: https://lib.dr.iastate.edu/rtd/4451

Subjects/Keywords: Lactation; Mammary glands; Hormones; Rats; Physiology; Animal Sciences; Physiology; Veterinary Physiology

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Ferreri, L. F. (1971). Experimental lactogenesis: Role of pituitary, adrenal, and ovarian hormones in initiating milk secretion in rats. (Thesis). Iowa State University. Retrieved from https://lib.dr.iastate.edu/rtd/4451

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Ferreri, Laurance Faye. “Experimental lactogenesis: Role of pituitary, adrenal, and ovarian hormones in initiating milk secretion in rats.” 1971. Thesis, Iowa State University. Accessed December 05, 2019. https://lib.dr.iastate.edu/rtd/4451.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Ferreri, Laurance Faye. “Experimental lactogenesis: Role of pituitary, adrenal, and ovarian hormones in initiating milk secretion in rats.” 1971. Web. 05 Dec 2019.

Vancouver:

Ferreri LF. Experimental lactogenesis: Role of pituitary, adrenal, and ovarian hormones in initiating milk secretion in rats. [Internet] [Thesis]. Iowa State University; 1971. [cited 2019 Dec 05]. Available from: https://lib.dr.iastate.edu/rtd/4451.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Ferreri LF. Experimental lactogenesis: Role of pituitary, adrenal, and ovarian hormones in initiating milk secretion in rats. [Thesis]. Iowa State University; 1971. Available from: https://lib.dr.iastate.edu/rtd/4451

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Michigan State University

26. Weldon, William C. Effects of elevated dietary energy and protein during late gestation on mammary development in gilts.

Degree: MS, Department of Animal Science, 1988, Michigan State University

URL: http://etd.lib.msu.edu/islandora/object/etd:20299

Subjects/Keywords: Swine – Feeding and feeds; Mammary glands; Sows; Proteins in animal nutrition

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Weldon, W. C. (1988). Effects of elevated dietary energy and protein during late gestation on mammary development in gilts. (Masters Thesis). Michigan State University. Retrieved from http://etd.lib.msu.edu/islandora/object/etd:20299

Chicago Manual of Style (16^th Edition):

Weldon, William C. “Effects of elevated dietary energy and protein during late gestation on mammary development in gilts.” 1988. Masters Thesis, Michigan State University. Accessed December 05, 2019. http://etd.lib.msu.edu/islandora/object/etd:20299.

MLA Handbook (7^th Edition):

Weldon, William C. “Effects of elevated dietary energy and protein during late gestation on mammary development in gilts.” 1988. Web. 05 Dec 2019.

Vancouver:

Weldon WC. Effects of elevated dietary energy and protein during late gestation on mammary development in gilts. [Internet] [Masters thesis]. Michigan State University; 1988. [cited 2019 Dec 05]. Available from: http://etd.lib.msu.edu/islandora/object/etd:20299.

Council of Science Editors:

Weldon WC. Effects of elevated dietary energy and protein during late gestation on mammary development in gilts. [Masters Thesis]. Michigan State University; 1988. Available from: http://etd.lib.msu.edu/islandora/object/etd:20299

27. McConnell, Sean C. Hemoglobin switching, thalassemia and sickle cell disease in humanized knockin mice.

Degree: PhD, 2011, University of Alabama – Birmingham

URL: http://contentdm.mhsl.uab.edu/u?/etd,1155

►

In this dissertation we describe knockin mouse models for the study of human hemoglobin disorders. These knockin human globin genes, in contrast to transgenes, replace… (more)

Subjects/Keywords: Disease Models, Animal<; br>; Fetal Hemoglobin – genetics<; br>; Fetal Hemoglobin – metabolism<; br>; beta-Globins – genetics<; br>; beta-Globins – metabolism<; br>; gamma-Globins – genetics<; br>; gamma-Globins – metabolism<; br>; beta-Thalassemia – therapy<; br>

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

McConnell, S. C. (2011). Hemoglobin switching, thalassemia and sickle cell disease in humanized knockin mice. (Doctoral Dissertation). University of Alabama – Birmingham. Retrieved from http://contentdm.mhsl.uab.edu/u?/etd,1155

Chicago Manual of Style (16^th Edition):

McConnell, Sean C. “Hemoglobin switching, thalassemia and sickle cell disease in humanized knockin mice.” 2011. Doctoral Dissertation, University of Alabama – Birmingham. Accessed December 05, 2019. http://contentdm.mhsl.uab.edu/u?/etd,1155.

MLA Handbook (7^th Edition):

McConnell, Sean C. “Hemoglobin switching, thalassemia and sickle cell disease in humanized knockin mice.” 2011. Web. 05 Dec 2019.

Vancouver:

McConnell SC. Hemoglobin switching, thalassemia and sickle cell disease in humanized knockin mice. [Internet] [Doctoral dissertation]. University of Alabama – Birmingham; 2011. [cited 2019 Dec 05]. Available from: http://contentdm.mhsl.uab.edu/u?/etd,1155.

Council of Science Editors:

McConnell SC. Hemoglobin switching, thalassemia and sickle cell disease in humanized knockin mice. [Doctoral Dissertation]. University of Alabama – Birmingham; 2011. Available from: http://contentdm.mhsl.uab.edu/u?/etd,1155

28. Huffman, Derek M. Calorie restriction, exercise and body fat : effects on cancer and markers of longevity.

Degree: PhD, 2007, University of Alabama – Birmingham

URL: http://contentdm.mhsl.uab.edu/u?/etd,596

►

The benefits of calorie restriction (CR) have historically been attributed to a reduction in food intake. More recently, reduced fat stores have been proposed as… (more)

▼

The benefits of calorie restriction (CR) have historically been attributed to a reduction in food intake. More recently, reduced fat stores have been proposed as an important mediator of CR, spurring interest into the potential for changes in energy expenditure and body composition as a CR mimetic. In order to better understand the relationship of body composition, energetics, cancer and longevity, four separate studies were performed. In Experimental Aim 1, a mouse model of prostate cancer (TRAMP) was used to determine if leanness rather than reduced food intake is responsible for the cancer-preventative effect of CR. It was found that increasing energy expenditure via thermoregulation under fixed-food intake conditions, resulted in smaller, leaner mice, which had less cancer incidence and progression. This finding suggests that in terms of cancer prevention, leanness rather calorie intake per se, is more closely associated with the benefits associated with CR. In Experimental Aim 2, results suggest that the longevity protein SIRT1 is elevated in mouse and human prostate cancer, and may be paradoxically implicated in tumor promotion. Experimental Aim 3 found that liver SIRT1 was not significantly affected by acute or chronic exercise. Finally, the results from Aim 4 found that exercised mice were significantly leaner than their weight-matched counterparts which were calorie restricted. However, CR and exercise had disparate effects on longevity biomarkers, including more favorable changes in the insulin/IGF-1 axis with CR, while exercisers had less DNA damage. The results of this experiment imply that the inability of exercise in prior studies to increase lifespan could be due to a failure to fully mimic the physiologic effects of CR. More studies are needed to determine if the inability of exercise to fully mimic CR is inherent to exercise itself, or if the life-prolonging action of CR work independently of changes in energy balance and body composition.

1 online resource (x, 183 p. : ill., digital, PDF file)

Nutrition Sciences;

Health Professions;

exercise cancer aging longevity caloric restriction obesity

UNRESTRICTED

Advisors/Committee Members: Nagy, Tim R., Bamman, Marcas M. , Elgavish, Ada , Grizzle, William E. , Piyathilake, Chandrika J. , Tollefsbol, Trygve O..

Subjects/Keywords: Adenocarcinoma<; br>; Aging<; br>; Biological Markers – metabolism<; br>; Caloric Restriction<; br>; Gene Expression Regulation, Neoplastic<; br>; Physical Conditioning, Animal – physiology<; br>; Prostatic Neoplasms<; br>; Sirtuins – genetics

Record Details Similar Records Cite « Share

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Huffman, D. M. (2007). Calorie restriction, exercise and body fat : effects on cancer and markers of longevity. (Doctoral Dissertation). University of Alabama – Birmingham. Retrieved from http://contentdm.mhsl.uab.edu/u?/etd,596

Chicago Manual of Style (16^th Edition):

Huffman, Derek M. “Calorie restriction, exercise and body fat : effects on cancer and markers of longevity.” 2007. Doctoral Dissertation, University of Alabama – Birmingham. Accessed December 05, 2019. http://contentdm.mhsl.uab.edu/u?/etd,596.

MLA Handbook (7^th Edition):

Huffman, Derek M. “Calorie restriction, exercise and body fat : effects on cancer and markers of longevity.” 2007. Web. 05 Dec 2019.

Vancouver:

Huffman DM. Calorie restriction, exercise and body fat : effects on cancer and markers of longevity. [Internet] [Doctoral dissertation]. University of Alabama – Birmingham; 2007. [cited 2019 Dec 05]. Available from: http://contentdm.mhsl.uab.edu/u?/etd,596.

Council of Science Editors:

Huffman DM. Calorie restriction, exercise and body fat : effects on cancer and markers of longevity. [Doctoral Dissertation]. University of Alabama – Birmingham; 2007. Available from: http://contentdm.mhsl.uab.edu/u?/etd,596

29. Gao, Hong. Patterns of differential mRNA and protein expression during minus lens conpensation and recovery in tree shrew sclera.

Degree: PhD, 2009, University of Alabama – Birmingham

URL: http://contentdm.mhsl.uab.edu/u?/etd,749

►

During the juvenile period of human development, an emmetropization mechanism uses visual signals to precisely guide the axial length elongation rate of the eyes to… (more)

▼

During the juvenile period of human development, an emmetropization mechanism uses visual signals to precisely guide the axial length elongation rate of the eyes to the optical power to keep the images in sharp focus. However, almost a third of the U.S. population develops axial myopia, in which the eye is elongated relative to the focal plane. The aims of the study were to examine 27 genes and 6 proteins in tree shrew sclera for potential differential expression patterns during minus lens compensation and during recovery. The study hypothesized that, in response to hyperopia produced by a –5 D lens, specific molecules initiate and participate in ECM remodeling, which raises the scleral creep rate and increases the rate of axial elongation; and during recovery, some of the same molecules produce a reversed pattern mRNA, while other molecules are activated or return to normal such that the scleral creep rate is decreased and the axial elongation rate is slowed in response to the myopia that occurs when the –5 D lens is removed. Overall, nineteen of the genes showed differential changes in mRNA levels. Besides all three TGFβ isoforms and the three receptor subtypes, six matricellular proteins, THBS-1 and 2, TNC, SPARC, SPP1 and TGFBI also showed differential mRNA changes. Among them, THBS1 also showed positive correlation between the differential mRNA and protein levels. Changes in MT1-MMP and TIMP3 confirmed results of previous studies, but the possible involvement of ADAMTS 1 and 5 were new results involving matrix metalloproteinases. In general, this study showed that scleral fibroblasts differentiate between retinal “go” signals and retinal “stop” signals. This suggests that differential responses by the scleral fibroblasts contain important information about how scleral remodeling occurs during minus lens compensation and recovery. A signature of changes in gene expression that characterizes changes during compensation and recovery may help us to understand whether the sclera responds similarly to all types of “go” signals received from the retina, and if it responds similarly to all types of “stop” signals even when the visual stimulus producing those signals is different.

1 online resource (ix,138 p. : ill., digital, PDF file)

Vision Science

Optometry

tree shrew myopia emmetropization gene expression and protein quantification

UNRESTRICTED

Advisors/Committee Members: Norton, Thomas T., Cui, Xiangqin , Gross, Alecia K. , Murphy-Ullrich, Joanne E. , Pittler, Steven J..

Subjects/Keywords: Eye – anatomy & histology<; br>; Eye Proteins – metabolism<; br>; Gene Expression<; br>; Models, Animal<; br>; Myopia – etiology<; br>; RNA, Messenger – analysis<; br>; Sclera – cytology<; br>; Tupaiidae

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Gao, H. (2009). Patterns of differential mRNA and protein expression during minus lens conpensation and recovery in tree shrew sclera. (Doctoral Dissertation). University of Alabama – Birmingham. Retrieved from http://contentdm.mhsl.uab.edu/u?/etd,749

Chicago Manual of Style (16^th Edition):

Gao, Hong. “Patterns of differential mRNA and protein expression during minus lens conpensation and recovery in tree shrew sclera.” 2009. Doctoral Dissertation, University of Alabama – Birmingham. Accessed December 05, 2019. http://contentdm.mhsl.uab.edu/u?/etd,749.

MLA Handbook (7^th Edition):

Gao, Hong. “Patterns of differential mRNA and protein expression during minus lens conpensation and recovery in tree shrew sclera.” 2009. Web. 05 Dec 2019.

Vancouver:

Gao H. Patterns of differential mRNA and protein expression during minus lens conpensation and recovery in tree shrew sclera. [Internet] [Doctoral dissertation]. University of Alabama – Birmingham; 2009. [cited 2019 Dec 05]. Available from: http://contentdm.mhsl.uab.edu/u?/etd,749.

Council of Science Editors:

Gao H. Patterns of differential mRNA and protein expression during minus lens conpensation and recovery in tree shrew sclera. [Doctoral Dissertation]. University of Alabama – Birmingham; 2009. Available from: http://contentdm.mhsl.uab.edu/u?/etd,749

Michigan State University

30. Zhu, Yirong. Effects of pubertal high fat diet and overweight on mammary tumorigenesis in FVB and BALB/c mice.

Degree: 2016, Michigan State University

URL: http://etd.lib.msu.edu/islandora/object/etd:4014

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Thesis Ph. D. Michigan State University. Cell and Molecular Biology 2016.

High animal fat diet (HFD) has long been suspected to increase breast cancer risk.… (more)

Subjects/Keywords: Mammary glands – Tumors – Etiology; Mammary glands – Tumors – Nutritional aspects; Breast – Tumors – Etiology; Breast – Cancer – Nutritional aspects; Carcinogenesis; Biology; Cellular biology; Physiology

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Zhu, Y. (2016). Effects of pubertal high fat diet and overweight on mammary tumorigenesis in FVB and BALB/c mice. (Thesis). Michigan State University. Retrieved from http://etd.lib.msu.edu/islandora/object/etd:4014

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Zhu, Yirong. “Effects of pubertal high fat diet and overweight on mammary tumorigenesis in FVB and BALB/c mice.” 2016. Thesis, Michigan State University. Accessed December 05, 2019. http://etd.lib.msu.edu/islandora/object/etd:4014.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Zhu, Yirong. “Effects of pubertal high fat diet and overweight on mammary tumorigenesis in FVB and BALB/c mice.” 2016. Web. 05 Dec 2019.

Vancouver:

Zhu Y. Effects of pubertal high fat diet and overweight on mammary tumorigenesis in FVB and BALB/c mice. [Internet] [Thesis]. Michigan State University; 2016. [cited 2019 Dec 05]. Available from: http://etd.lib.msu.edu/islandora/object/etd:4014.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Zhu Y. Effects of pubertal high fat diet and overweight on mammary tumorigenesis in FVB and BALB/c mice. [Thesis]. Michigan State University; 2016. Available from: http://etd.lib.msu.edu/islandora/object/etd:4014

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Open Access Theses and Dissertations