subject:(Magnetic Iron Oxide Nanocrystals)

Indian Institute of Science

1. Chalasani, Rajesh. Functionalized Nanostructures : Iron Oxide Nanocrystals and Exfoliated Inorganic Nanosheets.

Degree: PhD, Faculty of Science, 2018, Indian Institute of Science

URL: http://etd.iisc.ac.in/handle/2005/3463

► This thesis consists of two parts. The first part deals with the magnetic properties of Fe3O4 nanocrystals and their possible application in water remediation. The… (more)

Subjects/Keywords: Nanostructures; Iron Oxide Nanocrystals; Exfoliated Inorgnaic Nanosheets; Iron Oxide Nanocrystals; Magnetic Nanocrystals; Magnetic Nanoparticles; Magnetic Iron Oxide Nanocrystals; Magnetic Nanoparticles; Surfactant Intercalation; Layered Materials - Delamination; [email protected]; Inorganic Nanosheets; Layered Double Hydroxide; Oleate Capped Magnetite Nanocrystals; Nanotechnology

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Chalasani, R. (2018). Functionalized Nanostructures : Iron Oxide Nanocrystals and Exfoliated Inorganic Nanosheets. (Doctoral Dissertation). Indian Institute of Science. Retrieved from http://etd.iisc.ac.in/handle/2005/3463

Chicago Manual of Style (16^th Edition):

Chalasani, Rajesh. “Functionalized Nanostructures : Iron Oxide Nanocrystals and Exfoliated Inorganic Nanosheets.” 2018. Doctoral Dissertation, Indian Institute of Science. Accessed January 23, 2021. http://etd.iisc.ac.in/handle/2005/3463.

MLA Handbook (7^th Edition):

Chalasani, Rajesh. “Functionalized Nanostructures : Iron Oxide Nanocrystals and Exfoliated Inorganic Nanosheets.” 2018. Web. 23 Jan 2021.

Vancouver:

Chalasani R. Functionalized Nanostructures : Iron Oxide Nanocrystals and Exfoliated Inorganic Nanosheets. [Internet] [Doctoral dissertation]. Indian Institute of Science; 2018. [cited 2021 Jan 23]. Available from: http://etd.iisc.ac.in/handle/2005/3463.

Council of Science Editors:

Chalasani R. Functionalized Nanostructures : Iron Oxide Nanocrystals and Exfoliated Inorganic Nanosheets. [Doctoral Dissertation]. Indian Institute of Science; 2018. Available from: http://etd.iisc.ac.in/handle/2005/3463

Rice University

2. Mayo, John Thomas. The synthesis, characterization and application of iron oxide nanocrystals in magnetic separations for arsenic and uranium removal.

Degree: PhD, Natural Sciences, 2012, Rice University

URL: http://hdl.handle.net/1911/70343

► Arsenic and uranium in the environment are hazardous to human health and require better methods for detection and remediation. Nanocrystalline iron oxides offer a number… (more)

▼ Arsenic and uranium in the environment are hazardous to human health and require better methods for detection and remediation. Nanocrystalline iron oxides offer a number of advantages as sorbents for water purification and environmental remediation. First, highly uniform and crystalline iron oxide nanocrystals (nMAG) were prepared using thermal decomposition of iron salts in organic solutions; for the applications of interest in this thesis, a central challenge was the adaptation of these conventional synthetic methods to the needs of low infrastructure and economically disadvantaged settings. We show here that it is possible to form highly uniform and magnetically responsive nanomaterials using starting reagents and equipment that are readily available and economical. The products of this approach, termed the 'Kitchen Synthesis', are of comparable quality and effectiveness to laboratory materials. The narrow size distributions of the iron oxides produced in the laboratory synthesis made it possible to study the size-dependence of the magnetic separation efficiency of nanocrystals; generally as the diameter of particles increased they could be removed under lower applied magnetic fields. In this work we take advantage of this size-dependence to use magnetic separation as a tool to separate broadly distributed populations of magnetic materials. Such work makes it possible to use these materials in multiplexed separation and sensing schemes. With the synthesis and magnetic separation studies of these materials completed, it was possible to optimize their applications in water purification and environmental remediation. These materials removed both uranium and arsenic from contaminated samples, and had remarkably high sorption capacities – up to 12 wt% for arsenic and 30 wt% for uranium. The contaminated nMAG is removed from the drinking water by either retention in a sand column, filter, or by magnetic separation. The uranium adsorption process was also utilized for the enhanced detection of uranium in environmental matrices. By relying on α-particle detection in well-formed and dense nMAG films, it was possible to improve soil detection of uranium by more than ten-thousand-fold. Central for this work was a detailed understanding of the chemistry at the iron oxide interface, and the role of the organic coatings in mediating the sorption process. Advisors/Committee Members: Colvin, Vicki L. (advisor).

Subjects/Keywords: Applied sciences; Pure sciences; Iron oxide; Nanocrystals; Magnetic separations; Arsenic; Uranium; Inorganic chemistry; Nanoscience; Environmental engineering

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Mayo, J. T. (2012). The synthesis, characterization and application of iron oxide nanocrystals in magnetic separations for arsenic and uranium removal. (Doctoral Dissertation). Rice University. Retrieved from http://hdl.handle.net/1911/70343

Chicago Manual of Style (16^th Edition):

Mayo, John Thomas. “The synthesis, characterization and application of iron oxide nanocrystals in magnetic separations for arsenic and uranium removal.” 2012. Doctoral Dissertation, Rice University. Accessed January 23, 2021. http://hdl.handle.net/1911/70343.

MLA Handbook (7^th Edition):

Mayo, John Thomas. “The synthesis, characterization and application of iron oxide nanocrystals in magnetic separations for arsenic and uranium removal.” 2012. Web. 23 Jan 2021.

Vancouver:

Mayo JT. The synthesis, characterization and application of iron oxide nanocrystals in magnetic separations for arsenic and uranium removal. [Internet] [Doctoral dissertation]. Rice University; 2012. [cited 2021 Jan 23]. Available from: http://hdl.handle.net/1911/70343.

Council of Science Editors:

Mayo JT. The synthesis, characterization and application of iron oxide nanocrystals in magnetic separations for arsenic and uranium removal. [Doctoral Dissertation]. Rice University; 2012. Available from: http://hdl.handle.net/1911/70343

3. Kunyu, Liang. SYNTHESIS AND CHARACTERIZATION OF IRON OXIDE NANOPARTICLES FOR INCORPORATION INTO ORGANIC ELECTRONIC DEVICES.

Degree: MASc, 2018, McMaster University

URL: http://hdl.handle.net/11375/22833

►

Surface modification of electrodes becomes a powerful process to improve the performance of organic electronic devices such as organic light emitting diodes (OLEDs) and organic… (more)

▼

Surface modification of electrodes becomes a powerful process to improve the performance of organic electronic devices such as organic light emitting diodes (OLEDs) and organic photovoltaic cells (OPVs), boosting their further commercialization. Effective improvement can be achieved by introducing several types of nanoparticles onto the electrodes. Magnetic fields also have influence in the organic electronics, due to charge transport mechanisms of organic semiconducting materials. Therefore, magnetic nanoparticles are of particular interest. Magnetic γ-Fe2O3 nanoparticles have been produced using diblock copolymer reverse micelles method. The processes were elucidated in detail by Raman spectroscopy to reveal the iron oxide evolution. Compositional and structural information of individual γ-Fe2O3 nanoparticles were also characterized thoroughly by transmission electron microscopy (TEM) equipped with energy-dispersive X-ray spectroscopy (EDX) and electron energy loss spectroscopy (EELS), while their magnetic properties of the nanoparticles arrays were also evaluated by superconducting quantum interference device (SQUID) magnetometer. The low temperature annealing process was developed to facilitate the incorporation of γ-Fe2O3 nanoparticles in practical devices. Introducing γ-Fe2O3 nanoparticles onto the anode of basic OPV devices showed a positive effect on performance during the preliminary test. By using several methods, dispersion of γ-Fe2O3 nanoparticles can be tuned, examined by disLocate which is a comprehensive suite of tools for quantitative dispersion analysis. Additionally, the size of the nanoparticles can be changed simply by changing the loading ratio of FeCl3 below the maximum loading which was determined by quantum mechanical mapping using atomic force microscopy (AFM-QNM). With high control in terms of size and dispersion, the magnetic γ-Fe2O3 nanoparticles are ready to be employed to study the surface modification and magnetic effect on organic electronic devices.

Thesis

Master of Applied Science (MASc)

Advisors/Committee Members: Ayse, Turak, Engineering Physics.

Subjects/Keywords: iron oxide; nanoparticles; structure; Raman; dispersion; magnetic

10 more images…

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Kunyu, L. (2018). SYNTHESIS AND CHARACTERIZATION OF IRON OXIDE NANOPARTICLES FOR INCORPORATION INTO ORGANIC ELECTRONIC DEVICES. (Masters Thesis). McMaster University. Retrieved from http://hdl.handle.net/11375/22833

Chicago Manual of Style (16^th Edition):

Kunyu, Liang. “SYNTHESIS AND CHARACTERIZATION OF IRON OXIDE NANOPARTICLES FOR INCORPORATION INTO ORGANIC ELECTRONIC DEVICES.” 2018. Masters Thesis, McMaster University. Accessed January 23, 2021. http://hdl.handle.net/11375/22833.

MLA Handbook (7^th Edition):

Kunyu, Liang. “SYNTHESIS AND CHARACTERIZATION OF IRON OXIDE NANOPARTICLES FOR INCORPORATION INTO ORGANIC ELECTRONIC DEVICES.” 2018. Web. 23 Jan 2021.

Vancouver:

Kunyu L. SYNTHESIS AND CHARACTERIZATION OF IRON OXIDE NANOPARTICLES FOR INCORPORATION INTO ORGANIC ELECTRONIC DEVICES. [Internet] [Masters thesis]. McMaster University; 2018. [cited 2021 Jan 23]. Available from: http://hdl.handle.net/11375/22833.

Council of Science Editors:

Kunyu L. SYNTHESIS AND CHARACTERIZATION OF IRON OXIDE NANOPARTICLES FOR INCORPORATION INTO ORGANIC ELECTRONIC DEVICES. [Masters Thesis]. McMaster University; 2018. Available from: http://hdl.handle.net/11375/22833

Rice University

4. Yin, Yu. Optimizing Magnetic Iron Oxide Nanoparticles for Cancer Theranostic Applications.

Degree: MS, Engineering, 2020, Rice University

URL: http://hdl.handle.net/1911/108834

► Magnetic iron oxide nanoparticles (MIONs) have unique physical-chemical properties for a wide range of biomedical applications, including targeted drug delivery, multimodality molecular imaging, thermal therapies,… (more)

Subjects/Keywords: magnetic iron oxide nanoparticles; cancer; theranostics

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Yin, Y. (2020). Optimizing Magnetic Iron Oxide Nanoparticles for Cancer Theranostic Applications. (Masters Thesis). Rice University. Retrieved from http://hdl.handle.net/1911/108834

Chicago Manual of Style (16^th Edition):

Yin, Yu. “Optimizing Magnetic Iron Oxide Nanoparticles for Cancer Theranostic Applications.” 2020. Masters Thesis, Rice University. Accessed January 23, 2021. http://hdl.handle.net/1911/108834.

MLA Handbook (7^th Edition):

Yin, Yu. “Optimizing Magnetic Iron Oxide Nanoparticles for Cancer Theranostic Applications.” 2020. Web. 23 Jan 2021.

Vancouver:

Yin Y. Optimizing Magnetic Iron Oxide Nanoparticles for Cancer Theranostic Applications. [Internet] [Masters thesis]. Rice University; 2020. [cited 2021 Jan 23]. Available from: http://hdl.handle.net/1911/108834.

Council of Science Editors:

Yin Y. Optimizing Magnetic Iron Oxide Nanoparticles for Cancer Theranostic Applications. [Masters Thesis]. Rice University; 2020. Available from: http://hdl.handle.net/1911/108834

University of Arizona

5. Smith, Steven P. Lanthanide-containing Nanostructured Materials .

Degree: 2011, University of Arizona

URL: http://hdl.handle.net/10150/145459

► The research described in this Dissertation is concerned generally with the exploration of the potential use of lanthanide elements in nanostructured materials for the purpose… (more)

▼ The research described in this Dissertation is concerned generally with the exploration of the potential use of lanthanide elements in nanostructured materials for the purpose of modification of the magnetic and optical properties. This is explored through a focus on the development of lanthanide-containing iron oxide nanosystems. Our objectives of producing lanthanide containing nanostructured materials with potentially useful optical and magnetic applications has been achieved through the development of lanthanide-doped Fe3O4 and -Fe2O3 nanoparticles, as well as a unique core-shell magnetic-upconverting nanoparticle system.Necessary background information on nanomaterials, rationale for the study of lanthanide-containing iron oxide nanosystems and context for discussion of the results obtained in each project is provided in the Introduction Chapter. The syntheses of Fe3O4 nanoparticles doped with Eu(III) and Sm(III) are discussed, along with structural characterization and magnetic property investigation of products In Chapter 2. The following Chapter expands the study of lanthanide doping to -Fe2O3, a closely related yet distinct magnetic nanoparticle system. A completely different synthesis is attempted, and comparisons between the two systems are made.The development of novel synthetic methodologies used to create such products has yielded high-quality lanthanide-containing materials and are evidenced by TEM images displaying nearly monodisperse particles in each of our efforts. The modifications to the magnetic properties resulting from lanthanide doping include theobservation of ferromagnetism in the Fe3O4 system and increased magnetic saturation of -Fe2O3 nanoparticles, and are characterized by VSM and the visual observation of magnetic alignment of products. Our efforts towards developing a novel methodology capable of producing high quality Fe3O4 nanoparticles, and subsequent characterization of products, were published in the Journal of the American Chemical Society.Optically active, magnetic, core-shell nanoparticles are investigated in Chapter 4 for the potential uses in diagnosis and treatment of cancer. This multifunctional system uses Fe3O4 as a magnetic core, shelled by upconverting lanthanide-containing nanomaterials, and is rendered biocompatible through encapsulation of the core-shell structure by a silica shell. Added functionality is achieved through amine functionalization of the silica surface, with the goal of coupling the inorganic nanoparticle with drug targeting groups. TEM results indicate successful formation of the core-shell nanoparticles, and expected magnetic and optical properties are shown by visual observation and luminescence spectroscopy, respectively. Advisors/Committee Members: Zheng, Zhiping (advisor), Lichtenberger, Dennis (committeemember), Miranda, Katrina (committeemember), Saavedra, S. Scott (committeemember), Armstrong, Neal R. (committeemember).

Subjects/Keywords: biomedical; doping; Iron oxide; Lanthanide; magnetic; Nano

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Smith, S. P. (2011). Lanthanide-containing Nanostructured Materials . (Doctoral Dissertation). University of Arizona. Retrieved from http://hdl.handle.net/10150/145459

Chicago Manual of Style (16^th Edition):

Smith, Steven P. “Lanthanide-containing Nanostructured Materials .” 2011. Doctoral Dissertation, University of Arizona. Accessed January 23, 2021. http://hdl.handle.net/10150/145459.

MLA Handbook (7^th Edition):

Smith, Steven P. “Lanthanide-containing Nanostructured Materials .” 2011. Web. 23 Jan 2021.

Vancouver:

Smith SP. Lanthanide-containing Nanostructured Materials . [Internet] [Doctoral dissertation]. University of Arizona; 2011. [cited 2021 Jan 23]. Available from: http://hdl.handle.net/10150/145459.

Council of Science Editors:

Smith SP. Lanthanide-containing Nanostructured Materials . [Doctoral Dissertation]. University of Arizona; 2011. Available from: http://hdl.handle.net/10150/145459

Victoria University of Wellington

6. Ferguson, Peter Maurer. Iron Nanoparticles as Magnetic Resonance Imaging Contrast Agents.

Degree: 2011, Victoria University of Wellington

URL: http://hdl.handle.net/10063/4448

► Magnetic nanoparticles are effective in a range of biomedical applications including magneticresonance imaging (MRI) contrast enhancement. The efficacy of nanoparticles ascontrast agents depends mainly on… (more)

▼ Magnetic nanoparticles are effective in a range of biomedical applications including magneticresonance imaging (MRI) contrast enhancement. The efficacy of nanoparticles ascontrast agents depends mainly on the surface chemistry and magnetic properties of theparticles, with a large magnetic moment inducing efficient transverse (T₂) relaxation ofprotons. This results in improved negative enhancement of MRI contrast on T₂ weightedsequences. Iron oxide nanoparticles (FeOx NPs) have been used in MRI for 20 years andare the only commercially available T₂ contrast agents. A significantly larger magneticmoment can potentially be achieved with iron nanoparticles (Fe NPs), but developmenthas been hampered by difficulty in preparing stable particles. In this study, stable Fe NPwere prepared by a novel, simple, synthesis and compared with FeOx NP as T₂ contrastagents in a range of MRI-based biomedical applications.The effectiveness of Fe NPs versus FeOx NPs to negatively enhance MRI contrast onT₂ weighted sequences was first examined in vitro. The Fe NPs and FeOx NPs werecharacterised by electron microscopy and found to be of similar size (16nm). The Fe NPspossessed a core of highly magnetic α-Fe inside a 3nm shell of FeOx of the same crystalstructure as the pure FeOx NPs. Both types of NP were coated with the same molecule,DMSA, to produce aqueous dispersions with similar hydrodynamic particle sizes andpharmacokinetics. When dispersed in gels and examined by MRI, the Fe NPs were foundto produce more than twice the amount of T₂ contrast change per unit concentrationrelative to FeOx NPs. When cells were labelled in vitro, Fe NPs produced greater T₂contrast enhancement in all cell types tested, whilst there was no significant difference in the uptake of iron or the cytotoxicity between cells labelled with Fe or FeOx NPs.To assess the clinical applicability of the nanoparticles in vivo, FeOx NPs and Fe NPswere administered to mice and MRI experiments were performed at 1.5 T. Contrast effectsof the NPs were examined in the liver, spleen and lymph nodes, as tissues in theseorgans are rich in phagocytic cells and have a strong tendency to take up circulatingNPs. In all three organs studied, the Fe NPs produced noticeably darker contrast thanthe FeOx NPs, providing twice the contrast improvement.One of the most intensely researched applications of magnetic nanoparticles in MRI is improving detection of cancer in the lymph nodes. To model the size and NP uptake ofsmall lymph node metastases in humans, a mouse model was developed by injecting 4T1breast cancer cells directly into the mouse spleen. Analysis of mice bearing 4T1 tumoursperformed at 1.5 T showed that Fe NPs produced better contrast than FeOx NPs andimproved the detection of small tumours in the spleen as determined by two blindedradiologists. Indeed, the heightened sensitivity and specificity improved the threshold ofcancer detection on previous studies performed at 1.5 T.It was then examined whether the improved T₂ contrast could enable new MRI applicationsin vivo. A novel… Advisors/Committee Members: Hermans, Ian, Tilley, Richard.

Subjects/Keywords: Iron / iron oxide core / shell nanoparticles; Magnetic resonance imaging; MRI; Iron oxide nanoparticles

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Ferguson, P. M. (2011). Iron Nanoparticles as Magnetic Resonance Imaging Contrast Agents. (Doctoral Dissertation). Victoria University of Wellington. Retrieved from http://hdl.handle.net/10063/4448

Chicago Manual of Style (16^th Edition):

Ferguson, Peter Maurer. “Iron Nanoparticles as Magnetic Resonance Imaging Contrast Agents.” 2011. Doctoral Dissertation, Victoria University of Wellington. Accessed January 23, 2021. http://hdl.handle.net/10063/4448.

MLA Handbook (7^th Edition):

Ferguson, Peter Maurer. “Iron Nanoparticles as Magnetic Resonance Imaging Contrast Agents.” 2011. Web. 23 Jan 2021.

Vancouver:

Ferguson PM. Iron Nanoparticles as Magnetic Resonance Imaging Contrast Agents. [Internet] [Doctoral dissertation]. Victoria University of Wellington; 2011. [cited 2021 Jan 23]. Available from: http://hdl.handle.net/10063/4448.

Council of Science Editors:

Ferguson PM. Iron Nanoparticles as Magnetic Resonance Imaging Contrast Agents. [Doctoral Dissertation]. Victoria University of Wellington; 2011. Available from: http://hdl.handle.net/10063/4448

7. Κωστοπούλου, Αθανασία. Σύνθεση και χαρακτηρισμός υβριδικών δομών νανοκρυστάλλων με ρυθμιζόμενες ιδιότητες.

Degree: 2012, University of Crete (UOC); Πανεπιστήμιο Κρήτης

URL: http://hdl.handle.net/10442/hedi/28663

►

Considerable progress in the synthesis of colloidal inorganic nanocrystas has allowed their exploitation in different applications, ranging from electronics to biomedicine. A significant advancement in… (more)

▼

Considerable progress in the synthesis of colloidal inorganic nanocrystas has allowed their exploitation in different applications, ranging from electronics to biomedicine. A significant advancement in the syntheses of nanocrystals entails the capacity to afford not only single- but multi- material hybrids. This thesis presents the development of colloidal chemistry protocols and the characterization of a self-assembled secondary structure (nanocluster) and a hybrid multimaterial heterostructure. The nanoclusters involve a low cytotoxivity assembly of small γ-Fe2O3 nanocrystals (NCs). The colloidal assemblies are ferrimagnetic in aqueous dispersions and composed of crystallographically aligned NCs. The colloid of nanoclusters operates as a tunable photonic crystal under a moderate magnetic field. Their potential in biomedical diagnosis (MRI) and therapy (magnetic hyperthermia) is shown. Due to their tailored magneto-structural characteristics, the intra-cluster magnetic material volume fraction is raised, in turn producing a remarkable improvement of the transverse 1H-NMR relaxivity (4-5 times higher than that of the commercial contrast agent Endorem®) and a much higher Specific Loss Power is attained than that of other rival nanostructures. The hybrid heterostructure consists of ZnO nanorods uniformly covered by size-tunable [email protected] core-shell nanocrystals. The bi-functional [cf. with near band-edge (NBE) UV fluorescence and ferromagnetism at 300 K] nanomaterial is characterized by an extended surface coverage with small [email protected] nanodomains, where the interfacial coupling across the Fe-core and FexOy-shell generates exchange-bias, mediated by frozen interfacial spins. In the case of a lower coverage density by larger [email protected] domains, the operating Kirkendall effect between the core and the shell suppresses the exchange coupling anisotropy. Importantly, the interfacial interactions between [email protected] scale with the degree of surface coverage and a strain-induced blue-shift of the NBE is observed.

Η σημαντική πρόοδος στη σύνθεση κολλοειδών ανόργανων νανοκρυστάλλων έχει επιτρέψει και την αξιοποίησή τους σε διάφορες εφαρμογές από την ηλεκτρονική μέχρι τη βιοιατρική. Αξιοσημείωτη πρόοδος στις συνθέσεις νανοκρυστάλλων έχει οδηγήσει στη δυνατότητα παρασκευής υβριδικών νανοκρυστάλλων όχι μόνο μιας φάσης, αλλά και συνδυασμού διαφορετικών υλικών. Σε αυτήν την κατεύθυνση, η διατριβή αυτή παρουσιάζει την ανάπτυξη με μεθόδους κολλοειδούς χημείας και το χαρακτηρισμό μιας δευτερογενούς δομής που έχει σχηματιστεί από αυτοοργάνωση νανοκρυστάλλων (νανοσυσσωμάτωμα) και μιας υβριδικής ετεροδομής πολλαπλών υλικών. Το νανοσυσσωμάτωμα είναι χαμηλής κυτταροτοξικότητας και προέκυψε από αυτοοργάνωση μικρών νανοκρυστάλλων Fe2O3. Στα υδατικά τους διαλύματα είναι σιδηριμαγνητικά και αποτελούνται από κρυσταλλογραφικά προσανατολισμένους νανοκρυστάλλους. Το κολλοειδές διάλυμα των νανοσυσσωματωμάτων λειτουργεί επίσης ως ελεγχόμενος φωτονικός κρύσταλλος υπό την εφαρμογή ενός κατάλληλου μαγνητικού πεδίου. Επιπλέον, παρουσιάζεται η δυνατότητα…

Subjects/Keywords: Νανοσυσσωμάτωμα; Υβριδική ετεροδομή; Μαγνητικοί νανοκρύσταλλοι; Κολλοειδής χημεία; Απεικόνιση μαγνητικού συντονισμού; Σκιαγραφικό μέσο; Δομή πυρήνα-κελύφους; Οξείδιο του σιδήρου; Πόλωση λόγω ανταλλαγής; Μαγνητική υπερθερμία; Nanocluster; Hybrid heterostructure; Magnetic nanocrystals; Colloidal chemistry; Magnetic resonance imaging; Contrast agent; Core-shell structure; Iron oxide; Exchange bias; Magnetic Hyperthermia

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Κωστοπούλου, . �. (2012). Σύνθεση και χαρακτηρισμός υβριδικών δομών νανοκρυστάλλων με ρυθμιζόμενες ιδιότητες. (Thesis). University of Crete (UOC); Πανεπιστήμιο Κρήτης. Retrieved from http://hdl.handle.net/10442/hedi/28663

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Κωστοπούλου, Αθανασία. “Σύνθεση και χαρακτηρισμός υβριδικών δομών νανοκρυστάλλων με ρυθμιζόμενες ιδιότητες.” 2012. Thesis, University of Crete (UOC); Πανεπιστήμιο Κρήτης. Accessed January 23, 2021. http://hdl.handle.net/10442/hedi/28663.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Κωστοπούλου, Αθανασία. “Σύνθεση και χαρακτηρισμός υβριδικών δομών νανοκρυστάλλων με ρυθμιζόμενες ιδιότητες.” 2012. Web. 23 Jan 2021.

Vancouver:

Κωστοπούλου �. Σύνθεση και χαρακτηρισμός υβριδικών δομών νανοκρυστάλλων με ρυθμιζόμενες ιδιότητες. [Internet] [Thesis]. University of Crete (UOC); Πανεπιστήμιο Κρήτης; 2012. [cited 2021 Jan 23]. Available from: http://hdl.handle.net/10442/hedi/28663.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Κωστοπούλου �. Σύνθεση και χαρακτηρισμός υβριδικών δομών νανοκρυστάλλων με ρυθμιζόμενες ιδιότητες. [Thesis]. University of Crete (UOC); Πανεπιστήμιο Κρήτης; 2012. Available from: http://hdl.handle.net/10442/hedi/28663

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Texas A&M University

8. Chen, Tai-Yen. Electronic and Magnetization Dynamics of Cobalt Substituted Iron Oxide Nanocrystals.

Degree: PhD, Chemistry, 2011, Texas A&M University

URL: http://hdl.handle.net/1969.1/ETD-TAMU-2010-12-8838

► Knowledge of energy dissipation and relaxation in electron, spin, and lattice degrees of freedom is of fundamental importance from both a technological and scientific point… (more)

▼ Knowledge of energy dissipation and relaxation in electron, spin, and lattice degrees of freedom is of fundamental importance from both a technological and scientific point of view. In this dissertation, the electronic and magnetization dynamics of photoexcited colloidal cobalt substituted iron oxide nanocrystals, CoxFe3-xO4, were investigated through transient absorption and pump-probe Faraday rotation measurements. In this dissertation, linearly polarized femtosecond optical pulses at 780 nm were used to excite the weak absorption originating from the intervalence charge transfer transition (IVCT) between Fe2+ and Fe3+ ions of Fe3O4 nanocrystals. The timescale and corresponding relaxation processes of electronic relaxation dynamics of the excited IVCT state were first discussed. Size effect on electronic relaxation dynamics in Fe3O4 nanocrystals is not distinct on the basis of result from this study. One interesting feature of electronic dynamics data of photoexcited Fe3O4 nanocrystals is the creation of coherent acoustic phonons. Information on lattice temperature was obtained by measuring the period of coherent acoustic phonon as a function of excitation fluence and fit into a simple model based on Lamb’s theory. Since optical control of the magnetization can be either through optical or heating mechanisms, quantitative estimation of degree of demagnetization caused by lattice temperature is made by using Langevin function. The result from such estimation indicates the effect of lattice temperature rise on magnetization is too small to significantly affect the magnetization of Fe3O4 nanocrystals. Magnetization dynamics were studied via pump-probe Faraday rotation measurements. Optical excitation with near-infrared pulse resulted in an ultrafast demagnetization in 100fs. The energy of the excited state then relaxed through spin-lattice relaxation (SLR). Effects of surface spin and chemical tuning on the SLR were investigated by comparing the magnetization recovery timescales of nanocrystal with different particle sizes and cobalt concentration respectively. The experimental result is explained by a simple model where interior and surface spins contributed to the spin-lattice relaxation process differently. The observations suggest that spin-orbit coupling of the surface is stronger and less sensitive to stoichiometric variation than the interior spins of the nanocrystals. Advisors/Committee Members: Son, Dong Hee (advisor), Cremer, Paul S. (committee member), North, Simon W. (committee member), Schuessler, Hans A. (committee member).

Subjects/Keywords: Iron oxide nanocrystals; Dynamics; Magnetization; Faraday rotation; Spin-lattice relaxation; Lattice temperature

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Chen, T. (2011). Electronic and Magnetization Dynamics of Cobalt Substituted Iron Oxide Nanocrystals. (Doctoral Dissertation). Texas A&M University. Retrieved from http://hdl.handle.net/1969.1/ETD-TAMU-2010-12-8838

Chicago Manual of Style (16^th Edition):

Chen, Tai-Yen. “Electronic and Magnetization Dynamics of Cobalt Substituted Iron Oxide Nanocrystals.” 2011. Doctoral Dissertation, Texas A&M University. Accessed January 23, 2021. http://hdl.handle.net/1969.1/ETD-TAMU-2010-12-8838.

MLA Handbook (7^th Edition):

Chen, Tai-Yen. “Electronic and Magnetization Dynamics of Cobalt Substituted Iron Oxide Nanocrystals.” 2011. Web. 23 Jan 2021.

Vancouver:

Chen T. Electronic and Magnetization Dynamics of Cobalt Substituted Iron Oxide Nanocrystals. [Internet] [Doctoral dissertation]. Texas A&M University; 2011. [cited 2021 Jan 23]. Available from: http://hdl.handle.net/1969.1/ETD-TAMU-2010-12-8838.

Council of Science Editors:

Chen T. Electronic and Magnetization Dynamics of Cobalt Substituted Iron Oxide Nanocrystals. [Doctoral Dissertation]. Texas A&M University; 2011. Available from: http://hdl.handle.net/1969.1/ETD-TAMU-2010-12-8838

University of Western Ontario

9. Bannerman, Alexandra D. Design and Fabrication of a Multifunctional Nano-on-micro Delivery System.

Degree: 2015, University of Western Ontario

URL: https://ir.lib.uwo.ca/etd/2868

► The treatment of tumours using microbeads for embolization and drug delivery is a widely used, but often ineffective, technique. In this work, we aim to… (more)

Subjects/Keywords: microbeads; trans-arterial chemoembolization; poly(vinyl alcohol); iron oxide nanoparticles; cellulose nanocrystals; degradable hydrogel; Biomaterials

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Bannerman, A. D. (2015). Design and Fabrication of a Multifunctional Nano-on-micro Delivery System. (Thesis). University of Western Ontario. Retrieved from https://ir.lib.uwo.ca/etd/2868

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Bannerman, Alexandra D. “Design and Fabrication of a Multifunctional Nano-on-micro Delivery System.” 2015. Thesis, University of Western Ontario. Accessed January 23, 2021. https://ir.lib.uwo.ca/etd/2868.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Bannerman, Alexandra D. “Design and Fabrication of a Multifunctional Nano-on-micro Delivery System.” 2015. Web. 23 Jan 2021.

Vancouver:

Bannerman AD. Design and Fabrication of a Multifunctional Nano-on-micro Delivery System. [Internet] [Thesis]. University of Western Ontario; 2015. [cited 2021 Jan 23]. Available from: https://ir.lib.uwo.ca/etd/2868.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Bannerman AD. Design and Fabrication of a Multifunctional Nano-on-micro Delivery System. [Thesis]. University of Western Ontario; 2015. Available from: https://ir.lib.uwo.ca/etd/2868

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of New South Wales

10. Cheung, Jeffrey. Exploring size and interfacing effects of oxide nanocrystals.

Degree: Materials Science & Engineering, 2015, University of New South Wales

URL: http://handle.unsw.edu.au/1959.4/55125 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:36578/SOURCE02?view=true

► Oxide materials possess functional properties with utility in many applications ranging from electronic, optical, magnetic to catalytic. Current understandings into fundamental behaviour of oxide nanomaterials… (more)

Subjects/Keywords: Nanocrystals; Oxide; Epitaxy

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Cheung, J. (2015). Exploring size and interfacing effects of oxide nanocrystals. (Doctoral Dissertation). University of New South Wales. Retrieved from http://handle.unsw.edu.au/1959.4/55125 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:36578/SOURCE02?view=true

Chicago Manual of Style (16^th Edition):

Cheung, Jeffrey. “Exploring size and interfacing effects of oxide nanocrystals.” 2015. Doctoral Dissertation, University of New South Wales. Accessed January 23, 2021. http://handle.unsw.edu.au/1959.4/55125 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:36578/SOURCE02?view=true.

MLA Handbook (7^th Edition):

Cheung, Jeffrey. “Exploring size and interfacing effects of oxide nanocrystals.” 2015. Web. 23 Jan 2021.

Vancouver:

Cheung J. Exploring size and interfacing effects of oxide nanocrystals. [Internet] [Doctoral dissertation]. University of New South Wales; 2015. [cited 2021 Jan 23]. Available from: http://handle.unsw.edu.au/1959.4/55125 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:36578/SOURCE02?view=true.

Council of Science Editors:

Cheung J. Exploring size and interfacing effects of oxide nanocrystals. [Doctoral Dissertation]. University of New South Wales; 2015. Available from: http://handle.unsw.edu.au/1959.4/55125 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:36578/SOURCE02?view=true

Stellenbosch University

11. Van Deventer, Nedine. Electrospun composite nanofibres with magnetic carbon nanotubes.

Degree: MSc, Chemistry and Polymer Science, 2016, Stellenbosch University

URL: http://hdl.handle.net/10019.1/98333

► ENGLISH ABSTRACT: Functional composite nanofibres incorporated with magnetic carbon nanotubes (CNTs) were successfully synthesized using the electrospinning technique. This is the first example of the… (more)

▼ ENGLISH ABSTRACT: Functional composite nanofibres incorporated with magnetic carbon nanotubes (CNTs) were successfully synthesized using the electrospinning technique. This is the first example of the preparation of such composite nanofibres. In this study, a nanofibrous mat of electrospun nanofibres constitutes the polymer matrix, with the addition of various CNTs as reinforcing nanomaterials in order to form polymer/CNT nanocomposites (PCNs). Poly(methyl methacrylate) homopolymer, possessing a sufficiently high molar mass for electrospinning, was synthesized for use as polymer matrix. The effect that the polymer solution parameters, processing parameters and ambient parameters have on the fibre morphology are discussed. In a parallel study, multi-wall carbon nanotubes (MWCNTs) and magnetic CNTs (with controlled amounts of magnetic nanoparticles embedded in the walls) were chemically modified by means of oxidation and subsequent polymer grafting. Chemical modification was carried out in order to compatibilize the reinforcing nanomaterials with the polymer matrix for production of PCNs with a well dispersed and exfoliated structure. As a comparison to the magnetic CNTs mentioned above, magnetic CNTs were synthesized by decorating the surface of oxidized MWCNTs with magnetic nanoparticles. Decoration was made possible by carboxylic acid moieties present on the oxidized MWCNT backbone, which acted as anchoring sites through which chemical functionalities could be attached. Successful synthesis of MWCNT-Fe3O4 was achieved using an ex-situ and simpler single-step in-situ approach. Compatibilization with the polymer matrix for production of PCNs is achieved via the remaining carboxylic acid functionalities present as a result of initial oxidation. The various CNTs were incorporated into electrospun nanofibres as reinforcing nanomaterials and PCNs were thus formed. Increasing amounts of the various CNTs were added to the electrospinning polymer solution. By the addition of CNTs, the viscosity of the electrospinning solution increased, which prevented efficient electrospinning. The polymer concentration was, therefore, varied in specific ratios depending on the amount of CNTs incorporated. The effect the addition of CNTs has on the fibre morphology is discussed. After electrospinning, fibres in the nanometer range were obtained. Successful incorporation, and thus interaction of the CNTs with the electrospun polymer matrix, was confirmed by scanning transmission electron microscopy (STEM) images which verified the presence of well distributed CNTs which align along the electrospun polymer nanofibres due to the stretching of the fibres during electrospinning. The magnetic response of nanofibres reinforced with ex-situ and in-situ MWCNT-Fe3O4 exhibited superparamagnetic behaviour; as was proved with superconducting quantum interference device magnetometry where curves with the characteristic sigmoidal shape showing zero coercivity, zero remanence and no hysteresis loops were obtained. In summation, property enhancement of… Advisors/Committee Members: Mallon, Peter E., Stellenbosch University. Faculty of Science. Dept. of Chemistry and Polymer Science..

Subjects/Keywords: Magnetic carbon nanotubes; Iron oxide nanoparticles; Electrospinning; Nanocomposite nanofibres; UCTD

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Van Deventer, N. (2016). Electrospun composite nanofibres with magnetic carbon nanotubes. (Masters Thesis). Stellenbosch University. Retrieved from http://hdl.handle.net/10019.1/98333

Chicago Manual of Style (16^th Edition):

Van Deventer, Nedine. “Electrospun composite nanofibres with magnetic carbon nanotubes.” 2016. Masters Thesis, Stellenbosch University. Accessed January 23, 2021. http://hdl.handle.net/10019.1/98333.

MLA Handbook (7^th Edition):

Van Deventer, Nedine. “Electrospun composite nanofibres with magnetic carbon nanotubes.” 2016. Web. 23 Jan 2021.

Vancouver:

Van Deventer N. Electrospun composite nanofibres with magnetic carbon nanotubes. [Internet] [Masters thesis]. Stellenbosch University; 2016. [cited 2021 Jan 23]. Available from: http://hdl.handle.net/10019.1/98333.

Council of Science Editors:

Van Deventer N. Electrospun composite nanofibres with magnetic carbon nanotubes. [Masters Thesis]. Stellenbosch University; 2016. Available from: http://hdl.handle.net/10019.1/98333

12. HANNON, GARY. Assessing the potential of iron oxide nanoparticles to treat cancer through magnetic hyperthermia.

Degree: School of Medicine. Discipline of Clinical Medicine, 2020, Trinity College Dublin

URL: http://hdl.handle.net/2262/91585

► 5-year survival for pancreatic cancer is about 10% worldwide. A subset of this cancer, pancreatic ductal adenocarcinoma (PDAC), is estimated to become the second leading… (more)

Subjects/Keywords: Cancer; Toxicity; Iron oxide nanoparticles; Magnetic hyperthermia; Nanomedicine; Nanomaterials; Pancreatic cancer

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

HANNON, G. (2020). Assessing the potential of iron oxide nanoparticles to treat cancer through magnetic hyperthermia. (Thesis). Trinity College Dublin. Retrieved from http://hdl.handle.net/2262/91585

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

HANNON, GARY. “Assessing the potential of iron oxide nanoparticles to treat cancer through magnetic hyperthermia.” 2020. Thesis, Trinity College Dublin. Accessed January 23, 2021. http://hdl.handle.net/2262/91585.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

HANNON, GARY. “Assessing the potential of iron oxide nanoparticles to treat cancer through magnetic hyperthermia.” 2020. Web. 23 Jan 2021.

Vancouver:

HANNON G. Assessing the potential of iron oxide nanoparticles to treat cancer through magnetic hyperthermia. [Internet] [Thesis]. Trinity College Dublin; 2020. [cited 2021 Jan 23]. Available from: http://hdl.handle.net/2262/91585.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

HANNON G. Assessing the potential of iron oxide nanoparticles to treat cancer through magnetic hyperthermia. [Thesis]. Trinity College Dublin; 2020. Available from: http://hdl.handle.net/2262/91585

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universitat Autònoma de Barcelona

13. Carenza, Elisa. Engineering Iron Oxide Nanoparticles For Angiogenic Therapies.

Degree: Departament de Química, 2014, Universitat Autònoma de Barcelona

URL: http://hdl.handle.net/10803/284861

► The research was developed at the Institute of Materials Science of Barcelona (ICMAB-CSIC) and the Research Institute at Hospital Vall d'Hebron (VHIR) in Barcelona. The… (more)

▼ The research was developed at the Institute of Materials Science of Barcelona (ICMAB-CSIC) and the Research Institute at Hospital Vall d'Hebron (VHIR) in Barcelona. The main objective of the thesis is to develop materials for non-invasive therapies to promote blood vessel regeneration after an ischemic event. For that we used iron oxide magnetic nanoparticles for imaging (through Magnetic Resonance Imaging) and accumulation of proteins / cells into specific tissues under the influence of an external magnetic field. Two strategies have been developed: the first one by introducing magnetic nanoparticles in endothelial progenitor cells (EPCs) and the second one into polymeric nanocapsules together with a vascular growth factor. The thesis is organized in six chapters: CHAPTER 1 Superparamagnetic iron oxide nanoparticles (SPIONs) are known for their use in clinical diagnosis as contrast agents allowing the visualization of tissues through magnetic resonance imaging (MRI). The chapter contains a brief introduction to nanotechnology and a presentation of the magnetic properties of the materials. It also contains a review of the most common synthetic methods used to obtain superparamagnetic iron oxide nanoparticles. CHAPTER 2 In this chapter is described the synthesis of superparamagnetic iron oxide nanoparticles using two techniques: thermal decomposition and microwave assisted sol-gel route. Both methods allow to obtain monodisperse particles with size less than 20 nm and excellent magnetic properties. Particles have been successfully stabilized in water and different cell media by ionic stabilizers (tetramethylammonium hydroxide and sodium citrate). CHAPTER 3 Cerebral ischaemia is defined as the blockage of cerebral arteries, due to a thrombus or embolus, which produce tissue damage in the zone not perfused with blood. Brain tissue regeneration and repair, based on the improvement of endogenous angiogenesis, could become reality in the near future having identified endothelial progenitors (EPCs) cells in adults. The EPCs are cells that can induce revascularization and / or remodeling of blood vessels by release of angiogenic factors. Our goal is to enhance the therapeutic action of EPCs guiding them toward specific areas of the brain with an external magnetic field to enhance regeneration after cerebral stroke. Experiments of in vitro cell labeling, cell toxicity and functionality are described in this chapter. In addition we showed an in vivo experiment using animal models to demonstrate the accumulation of magnetized EPCs in the brain under a magnetic field due to an external magnet implantation. CHAPTER 4 Another strategy is to encapsulate growth factors together with magnetic nanoparticles (SPIONs) into biodegradable nanocapsules of poly (D,l-lactic-co-glycolic acid) (PLGA), so that these can be guided toward the brain injury by applying an external magnetic field. During the training period in the group of the Ecole de Pharmacie Genève-Lausanne (EPGL) I started the synthesis of polymeric nanocapsules… Advisors/Committee Members: [email protected] (authoremail), true (authoremailshow), Roig Serra, Anna (director), Rosell Novel, Anna (director), Rodriguez Viejo, Javier (tutor), true (authorsendemail).

Subjects/Keywords: Magnetic nanoparticles; Iron oxide; Angiogenic therapy; Ciències Experimentals; 61

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Carenza, E. (2014). Engineering Iron Oxide Nanoparticles For Angiogenic Therapies. (Thesis). Universitat Autònoma de Barcelona. Retrieved from http://hdl.handle.net/10803/284861

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Carenza, Elisa. “Engineering Iron Oxide Nanoparticles For Angiogenic Therapies.” 2014. Thesis, Universitat Autònoma de Barcelona. Accessed January 23, 2021. http://hdl.handle.net/10803/284861.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Carenza, Elisa. “Engineering Iron Oxide Nanoparticles For Angiogenic Therapies.” 2014. Web. 23 Jan 2021.

Vancouver:

Carenza E. Engineering Iron Oxide Nanoparticles For Angiogenic Therapies. [Internet] [Thesis]. Universitat Autònoma de Barcelona; 2014. [cited 2021 Jan 23]. Available from: http://hdl.handle.net/10803/284861.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Carenza E. Engineering Iron Oxide Nanoparticles For Angiogenic Therapies. [Thesis]. Universitat Autònoma de Barcelona; 2014. Available from: http://hdl.handle.net/10803/284861

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Illinois – Chicago

14. Pernal, Sebastian. Effects of Hydroxyapatite-Iron Oxide Nanocomposite Against Human Glioblastoma Cells.

Degree: 2016, University of Illinois – Chicago

URL: http://hdl.handle.net/10027/21574

► Cancer is the second leading cause of death in the United States and few treatments offer a panacea for all the various types of cancer… (more)

▼ Cancer is the second leading cause of death in the United States and few treatments offer a panacea for all the various types of cancer that exist. Certain superparamagnetic iron oxide nanoparticles (SPIONs) are FDA-approved as contrast agents in magnetic resonance imaging while the potential applications for SPIONs are numerous. One such application is magnetic hyperthermia (MH) where alternating magnetic fields applied to SPIONs generate heat. MH in treating cancer would cause cancer cells to deteriorate from the inside without the use of strong chemotherapeutics. SPION effectiveness is hindered by the low uptake in cancer cells and the generation of reactive oxygen species that cause harm to the healthy cells in the body. In early studies, healthy, primary mouse kidney and lung fibroblasts had an increased uptake of iron oxide nanoparticles (IONs) versus human brain cancer cells (E297 and U87) and mouse osteosarcomas (K7M2.) Hydroxyapatite (HAP), the primary ceramic in our bones, offers a solution to SPION delivery. HAP particles are commended as a biomaterial for their biodegradability and biocompatibility, and their use as a nonviral transfection agent. Dispersing IONS in HAP nanoparticles could increase the uptake in cancer cells and minimize the risk to healthy cells. The goal of this work is the construction and characterization of a hydroxyapatite-iron oxide nanocomposite (HAP-ION) usable as a device for magnetic hyperthermia, minimizing the risk to healthy cells and increasing their uptake in cancer cells. HAP-IONs retain the superparamagnetic nature of IONs, have increased uptake in cancer cells versus their ION counterparts, reduce cancer cell viability and primary cancer spheroid migration, and maintain the viability of healthy human mesenchymal stem cells (hMSCs). Further analysis of actin cytoskeleton revealed that healthy hMSCs have a reduced anisotropy in their cytoskeleton arrangement after the uptake of IONs, while primary cancerous cells have an increased anisotropy in cytoskeleton arrangement after the uptake of IONs. Nanocomposites of hydroxyapatite and IONs open a new avenue to cancer therapies that utilize MH. Advisors/Committee Members: Uskokovic, Vuk (advisor), Engelhard, Herbert H (committee member), Khetani, Salman R (committee member), Uskokovic, Vuk (chair).

Subjects/Keywords: Nanoparticles; nanocomposite; cancer; magnetic hyperthermia; glioblastoma; hydroxyapatite; iron oxide nanoparticles

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Pernal, S. (2016). Effects of Hydroxyapatite-Iron Oxide Nanocomposite Against Human Glioblastoma Cells. (Thesis). University of Illinois – Chicago. Retrieved from http://hdl.handle.net/10027/21574

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Pernal, Sebastian. “Effects of Hydroxyapatite-Iron Oxide Nanocomposite Against Human Glioblastoma Cells.” 2016. Thesis, University of Illinois – Chicago. Accessed January 23, 2021. http://hdl.handle.net/10027/21574.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Pernal, Sebastian. “Effects of Hydroxyapatite-Iron Oxide Nanocomposite Against Human Glioblastoma Cells.” 2016. Web. 23 Jan 2021.

Vancouver:

Pernal S. Effects of Hydroxyapatite-Iron Oxide Nanocomposite Against Human Glioblastoma Cells. [Internet] [Thesis]. University of Illinois – Chicago; 2016. [cited 2021 Jan 23]. Available from: http://hdl.handle.net/10027/21574.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Pernal S. Effects of Hydroxyapatite-Iron Oxide Nanocomposite Against Human Glioblastoma Cells. [Thesis]. University of Illinois – Chicago; 2016. Available from: http://hdl.handle.net/10027/21574

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Georgia

15. Scharf, Alexandra Michelle. Mri-based approach for longitudinal monitoring of intralesional therapy of mscs in a large animal model of tendonitis.

Degree: 2017, University of Georgia

URL: http://hdl.handle.net/10724/36890

► The goal of this dissertation was to establish a magnetic resonance imaging (MRI)-based tracking method for mesenchymal stem cells (MSCs) in ovine and equine models… (more)

▼ The goal of this dissertation was to establish a magnetic resonance imaging (MRI)-based tracking method for mesenchymal stem cells (MSCs) in ovine and equine models of tendonitis and to apply this method in a longitudinal assessment of cell tracking and tendon healing in vivo. The first aim was designed to establish a labeling method using superparamagnetic iron oxide nanoparticles (SPIOs) in sheep, validate detection limits in vitro and in vivo at 3 Tesla (T), and follow out sheep after injection of labeled cells for 7 and 14 days. Labeled, ovine MSCs remained viable, proliferate, and undergo tri-lineage differentiation and remained detectable in vitro in cell numbers as low as 10,000. Cells remained detectable in vivo by MRI at 7 days, as confirmed by correlative histology for dually labeled SPIO+/GFP+ cells, but cells were not confirmed at 14 days. The second aim was designed to establish a SPIO labeling method in the equine and to validate detection in a clinically relevant model of tendon injury at 1.5 T. Assays indicated no significant changes in cell viability, proliferation, migration, or tri-lineage differentiation due to the presence of SPIOs. Clusters of labeled cells were visible as signal voids in 6/6 subjects. Coalescing regions of signal void were diffusely present in the peritendinous tissues. Greater than expected delocalization of cells was present and relatively few cells were retained within collagenous tendon compared to surrounding fascia. The final aim was to non-invasively monitor cell migration and survival concurrent with healing in an ovine model of acute tendon injury over 28 weeks. SPIO-associated signal dropped off exponentially over the first 6 weeks, but remained present until 28 weeks. Standard deviation (SD) of MRI signal, signal to noise ratios (SNR), and signal difference to noise ratios (SDNR) decreased over time in all subjects. MSC-treated tendons had lower SD, SNR and SDNR than control and SPIO-MSC treated tendons at 28 weeks. Overall, SPIO-labeling appears to be an effective and safe method to label MSCs, although some drawbacks are present. MSC treatment appears to improve tendon healing, but care should be taken when assessing SPIO-labeled cells concurrently with tendon quality.

Subjects/Keywords: mesenchymal stem cells; magnetic resonance imaging; superparamagnetic iron oxide nanoparticles; tendonitis

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Scharf, A. M. (2017). Mri-based approach for longitudinal monitoring of intralesional therapy of mscs in a large animal model of tendonitis. (Thesis). University of Georgia. Retrieved from http://hdl.handle.net/10724/36890

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Scharf, Alexandra Michelle. “Mri-based approach for longitudinal monitoring of intralesional therapy of mscs in a large animal model of tendonitis.” 2017. Thesis, University of Georgia. Accessed January 23, 2021. http://hdl.handle.net/10724/36890.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Scharf, Alexandra Michelle. “Mri-based approach for longitudinal monitoring of intralesional therapy of mscs in a large animal model of tendonitis.” 2017. Web. 23 Jan 2021.

Vancouver:

Scharf AM. Mri-based approach for longitudinal monitoring of intralesional therapy of mscs in a large animal model of tendonitis. [Internet] [Thesis]. University of Georgia; 2017. [cited 2021 Jan 23]. Available from: http://hdl.handle.net/10724/36890.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Scharf AM. Mri-based approach for longitudinal monitoring of intralesional therapy of mscs in a large animal model of tendonitis. [Thesis]. University of Georgia; 2017. Available from: http://hdl.handle.net/10724/36890

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Michigan

16. Cole, Adam John. Enhancing Magnetic Iron Oxide Nanoparticle Targeting to Brain Tumors.

Degree: PhD, Pharmaceutical sciences, 2011, University of Michigan

URL: http://hdl.handle.net/2027.42/127181

► Brain tumors are highly lethal, most often resulting in a terminal prognosis. Today's standard-of-care has not significantly altered patient survival time. The status quo indicates… (more)

▼ Brain tumors are highly lethal, most often resulting in a terminal prognosis. Today's standard-of-care has not significantly altered patient survival time. The status quo indicates the need for a more targeted, multi-functional therapeutic approach. Nanotechnology has been implicated as a potential magic bullet drug carrier solution to cancer, with magnetic iron oxide nanoparticles (MNPs) representing a unique, magnetically responsive type of nanomaterial. MNPs have been targeted to brain tumors by applying an external magnetic field to lesions. The short circulation times of preferred MNPs, though, limits their availability for targeting, and, thus, tumor delivery. If plasma residence were enhanced, the question then arises: would targeting efficiency improve? This dissertation aimed to develop long-circulating MNPs suitable for enhanced magnetic brain tumor targeting. Aminosilane (A) and cross-linked starch coated, polyethylene glycol (PEG) conjugated MNP candidates were synthesized using N-hydroxysuccinimide chemistry and characterized. Candidates were similar in size (140 – 190 nm) and PEG content, (up to 1.5 mol %) and deemed magnetically suitable for targeting. Candidates were subjected to in vitro reticuloendothelial system simulations to predict long-circulating behavior in vivo. Unlike the A-platform, cross-linked starch PEG-MNPs (D5/D20) performed well in vitro showing sustained size stability in cell culture medium and up to 10-fold reduced uptake in RAW 264.7 macrophages, when compared to previously studied starch-coated MNPs (D). Simulations predicted improved circulation behavior, with intravenously administered D5/D20 (12 mg Fe/kg) showing up to an estimated 150-fold increase in tumor exposure over D in 9L-glioma bearing rats. Validated electron spin resonance methodology was used to study biodistribution of D5/D20 in tissues of elimination. MNP concentrations in the spleen were high, and, unexpectedly, appeared attenuated in the liver. Improved exposure of MNPs to rat 9L-glioma lesions resulted in enhanced magnetic brain tumor targeting (t=1 hr) with up to 1.0% injected dose (ID)/g tissue (200 g animal) delivery achieved, a 15-fold improvement over targeted D (0.07% ID/g tissue). Magnetic resonance imaging confirmed targeting enhancements. Results achieve proof-of-concept that long-circulating MNPs permit enhanced magnetic targeting of nanoparticles to brain tumors, warranting further development of the materials and strategy studied. Advisors/Committee Members: Yang, Victor C. (advisor).

Subjects/Keywords: Brain Tumors; Enhancing; Gliomas; Iron Oxide Nanoparticles; Magnetic; Nanoparticle; Polyethylene Oxide; Targeting

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Cole, A. J. (2011). Enhancing Magnetic Iron Oxide Nanoparticle Targeting to Brain Tumors. (Doctoral Dissertation). University of Michigan. Retrieved from http://hdl.handle.net/2027.42/127181

Chicago Manual of Style (16^th Edition):

Cole, Adam John. “Enhancing Magnetic Iron Oxide Nanoparticle Targeting to Brain Tumors.” 2011. Doctoral Dissertation, University of Michigan. Accessed January 23, 2021. http://hdl.handle.net/2027.42/127181.

MLA Handbook (7^th Edition):

Cole, Adam John. “Enhancing Magnetic Iron Oxide Nanoparticle Targeting to Brain Tumors.” 2011. Web. 23 Jan 2021.

Vancouver:

Cole AJ. Enhancing Magnetic Iron Oxide Nanoparticle Targeting to Brain Tumors. [Internet] [Doctoral dissertation]. University of Michigan; 2011. [cited 2021 Jan 23]. Available from: http://hdl.handle.net/2027.42/127181.

Council of Science Editors:

Cole AJ. Enhancing Magnetic Iron Oxide Nanoparticle Targeting to Brain Tumors. [Doctoral Dissertation]. University of Michigan; 2011. Available from: http://hdl.handle.net/2027.42/127181

Uniwersytet im. Adama Mickiewicza w Poznaniu

17. Leszczyński, Błażej. Nanocząstki tlenków żelaza w hipertermii magnetycznej .

Degree: 2016, Uniwersytet im. Adama Mickiewicza w Poznaniu

URL: http://hdl.handle.net/10593/14787

► Na początku pracy przedstawiono ogólne znaczenie hipertermii, jak również pokazano najważniejsze zastosowania nanocząstek magnetycznych w medycynie. W dalszej części streszczono metody wytwarzania nanocząstek. Opisano również… (more)

Subjects/Keywords: efekt hipertermiczny; magnetic hyperthermia; ciecz magnetyczna; ferrofluid; nanocząstki magnetyczne; magnetic nanoparticles; tlenki żelaza; iron oxide

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Leszczyński, B. (2016). Nanocząstki tlenków żelaza w hipertermii magnetycznej . (Doctoral Dissertation). Uniwersytet im. Adama Mickiewicza w Poznaniu. Retrieved from http://hdl.handle.net/10593/14787

Chicago Manual of Style (16^th Edition):

Leszczyński, Błażej. “Nanocząstki tlenków żelaza w hipertermii magnetycznej .” 2016. Doctoral Dissertation, Uniwersytet im. Adama Mickiewicza w Poznaniu. Accessed January 23, 2021. http://hdl.handle.net/10593/14787.

MLA Handbook (7^th Edition):

Leszczyński, Błażej. “Nanocząstki tlenków żelaza w hipertermii magnetycznej .” 2016. Web. 23 Jan 2021.

Vancouver:

Leszczyński B. Nanocząstki tlenków żelaza w hipertermii magnetycznej . [Internet] [Doctoral dissertation]. Uniwersytet im. Adama Mickiewicza w Poznaniu; 2016. [cited 2021 Jan 23]. Available from: http://hdl.handle.net/10593/14787.

Council of Science Editors:

Leszczyński B. Nanocząstki tlenków żelaza w hipertermii magnetycznej . [Doctoral Dissertation]. Uniwersytet im. Adama Mickiewicza w Poznaniu; 2016. Available from: http://hdl.handle.net/10593/14787

Georgia Tech

18. Quinto, Christopher Anthony. Developing multifunctional iron oxide nanoparticles for novel cancer therapeutic strategies.

Degree: PhD, Biomedical Engineering (Joint GT/Emory Department), 2015, Georgia Tech

URL: http://hdl.handle.net/1853/56157

► Magnetic nanoparticles hold tremendous potential to change the way we study the body and have the potential to revolutionize how we diagnose and treat disease.… (more)

Subjects/Keywords: Iron oxide nanoparticles; Drug delivery; Magnetic fluid hyperthermia; Magnetic resonance imaging; Theranostics

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Quinto, C. A. (2015). Developing multifunctional iron oxide nanoparticles for novel cancer therapeutic strategies. (Doctoral Dissertation). Georgia Tech. Retrieved from http://hdl.handle.net/1853/56157

Chicago Manual of Style (16^th Edition):

Quinto, Christopher Anthony. “Developing multifunctional iron oxide nanoparticles for novel cancer therapeutic strategies.” 2015. Doctoral Dissertation, Georgia Tech. Accessed January 23, 2021. http://hdl.handle.net/1853/56157.

MLA Handbook (7^th Edition):

Quinto, Christopher Anthony. “Developing multifunctional iron oxide nanoparticles for novel cancer therapeutic strategies.” 2015. Web. 23 Jan 2021.

Vancouver:

Quinto CA. Developing multifunctional iron oxide nanoparticles for novel cancer therapeutic strategies. [Internet] [Doctoral dissertation]. Georgia Tech; 2015. [cited 2021 Jan 23]. Available from: http://hdl.handle.net/1853/56157.

Council of Science Editors:

Quinto CA. Developing multifunctional iron oxide nanoparticles for novel cancer therapeutic strategies. [Doctoral Dissertation]. Georgia Tech; 2015. Available from: http://hdl.handle.net/1853/56157

University of Western Ontario

19. Melo, Kierstin P. Detection and Quantification of Cells using Magnetic Particle Imaging and Magnetic Microspheres.

Degree: 2020, University of Western Ontario

URL: https://ir.lib.uwo.ca/etd/7509

► Magnetic particle imaging (MPI) is an emerging imaging modality that specifically detects superparamagnetic iron oxide nanoparticles (SPIOs). Our lab has shown that cell tracking with… (more)

Subjects/Keywords: Magnetic Particle Imaging (MPI); Superparamagnetic Iron Oxide (SPIO); Micron-Sized Iron Oxide Particles (MPIO); Medical Biophysics

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Melo, K. P. (2020). Detection and Quantification of Cells using Magnetic Particle Imaging and Magnetic Microspheres. (Thesis). University of Western Ontario. Retrieved from https://ir.lib.uwo.ca/etd/7509

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Melo, Kierstin P. “Detection and Quantification of Cells using Magnetic Particle Imaging and Magnetic Microspheres.” 2020. Thesis, University of Western Ontario. Accessed January 23, 2021. https://ir.lib.uwo.ca/etd/7509.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Melo, Kierstin P. “Detection and Quantification of Cells using Magnetic Particle Imaging and Magnetic Microspheres.” 2020. Web. 23 Jan 2021.

Vancouver:

Melo KP. Detection and Quantification of Cells using Magnetic Particle Imaging and Magnetic Microspheres. [Internet] [Thesis]. University of Western Ontario; 2020. [cited 2021 Jan 23]. Available from: https://ir.lib.uwo.ca/etd/7509.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Melo KP. Detection and Quantification of Cells using Magnetic Particle Imaging and Magnetic Microspheres. [Thesis]. University of Western Ontario; 2020. Available from: https://ir.lib.uwo.ca/etd/7509

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Florida

20. Unni, Mythreyi. Semi-Batch High Temperature Synthesis of Iron-Oxide Nanoparticles for Application in Magnetically Mediated Energy Delivery.

Degree: MS, Chemical Engineering, 2015, University of Florida

URL: https://ufdc.ufl.edu/UFE0048960

► Tapping thermal energy dissipated by magnetic nanoparticles has been widely studied for biomedical applications. The heat generated is attributed to the magnetic moment of nanoparticles… (more)

▼ Tapping thermal energy dissipated by magnetic nanoparticles has been widely studied for biomedical applications. The heat generated is attributed to the magnetic moment of nanoparticles that relax either by physical rotation of the particle (Brownian mechanism) or by internal rotation of the dipole (Neel mechanism). For maximizing heat dissipation, focus has been on tuning the anisotropy constant, optimizing the physical core size, and narrowing the polydispersity of the particles. The following work emphasizes on size-tunable synthesis of superparamagnetic iron-oxide nanoparticles (SPIONs) with low polydispersity that relax by the Neel mechanism and improving their magnetic cores for magnetically mediated energy delivery applications. Fourier Transform Infrared (FTIR) studies confirmed the formation of iron oleate prepared using iron acetylacetonate and oleic acid. An attempt to achieve controlled growth was carried out by a semi-batch thermal decomposition route with continuous precursor addition. Efforts have been carried out to understand the effect of precursor drip rate, reaction temperature and surfactant concentration on nanoparticle growth with time. The physical diameter obtained from Transmission Electron Microscopy (TEM) images, the hydrodynamic diameter from Dynamic Light Scattering (DLS) measurements and the magnetic measurements from Superconducting Quantum Interference Device (SQUID) magnetometer gave evidence of the influence of varying reaction parameters on the rate of nucleation, growth and size focusing achieved during synthesis. Under an Alternating Magnetic Field (AMF) of amplitude 37.3 kA/m and frequency 343 kHz, localized heating induced in the particles was evaluated. A maximum heating efficiency was observed, as quantified by Specific Absorption Rate (SAR) measurements for particles with a magnetic core of 16 nm and physical diameter of 18 nm and that relaxed by the Neel mechanism. Though the SAR was found to peak and subsequently decrease as a function of size and relaxation time, high energy dissipation rates could not be achieved in some samples due to low yield of magnetic diameter in comparison to their physical sizes. Low magnetic diameters were due to the formation of undesirable oxides during synthesis. Ensuring transformation to magnetite or maghemite phase by thermal treatment after synthesis is envisioned to improve the magnetic diameter, and thereby the heating efficiency. ( en ) Advisors/Committee Members: RINALDI,CARLOS (committee chair).

Subjects/Keywords: Diameters; Heating; Iron oxides; Magnetic fields; Magnetism; Magnets; Monomers; Nanoparticles; Nucleation; Particle energy; heating – iron-oxide – magnetic – nanoparticle – sar

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Unni, M. (2015). Semi-Batch High Temperature Synthesis of Iron-Oxide Nanoparticles for Application in Magnetically Mediated Energy Delivery. (Masters Thesis). University of Florida. Retrieved from https://ufdc.ufl.edu/UFE0048960

Chicago Manual of Style (16^th Edition):

Unni, Mythreyi. “Semi-Batch High Temperature Synthesis of Iron-Oxide Nanoparticles for Application in Magnetically Mediated Energy Delivery.” 2015. Masters Thesis, University of Florida. Accessed January 23, 2021. https://ufdc.ufl.edu/UFE0048960.

MLA Handbook (7^th Edition):

Unni, Mythreyi. “Semi-Batch High Temperature Synthesis of Iron-Oxide Nanoparticles for Application in Magnetically Mediated Energy Delivery.” 2015. Web. 23 Jan 2021.

Vancouver:

Unni M. Semi-Batch High Temperature Synthesis of Iron-Oxide Nanoparticles for Application in Magnetically Mediated Energy Delivery. [Internet] [Masters thesis]. University of Florida; 2015. [cited 2021 Jan 23]. Available from: https://ufdc.ufl.edu/UFE0048960.

Council of Science Editors:

Unni M. Semi-Batch High Temperature Synthesis of Iron-Oxide Nanoparticles for Application in Magnetically Mediated Energy Delivery. [Masters Thesis]. University of Florida; 2015. Available from: https://ufdc.ufl.edu/UFE0048960

21. Ho, Don N. Iron Oxide, Gold-Silver Alloy, and Heterostructure Nanoparticles for Magnetic and Optical Theranostic Applications.

Degree: PhD, Chemistry, 2013, Brown University

URL: https://repository.library.brown.edu/studio/item/bdr:320491/

► Theranostics is the ability to diagnose with greater detail to disease properties and tailor specialized therapeutic regiments to a patient's unique case. Advancements in nanoparticle… (more)

▼ Theranostics is the ability to diagnose with greater detail to disease properties and tailor specialized therapeutic regiments to a patient's unique case. Advancements in nanoparticle synthesis for controlled material properties and further functionalization make the nano-scale materials promising candidates as a theranostic platform for predictive medicine, early detection, targeted therapy, and diagnostic monitoring. Here we examine iron oxide, gold-silver alloy, and gold-iron oxide dumbbell-like heterostructure nanoparticles for their combined diagnostic and therapeutic application. Iron oxide nanoparticles are used clinically as MRI contrast agents and also provide a platform for functionalization and further application of their magnetic properties. We examine the targeting of iron oxide to tumor vasculature using the tumstatin peptide in a three-dimensional in vitro tumor model and observe the therapeutic heating abilities in an alternating magnetic field. Surface enhanced fluorescence from nano-sized metal materials occurs through near-field coupling of the local electromagnetic field. We focus on controlling the surface plasmon resonance of AuAg alloy nanoparticles (AuAgNP) with a tunable method for transferring energy with fluorescent proteins. We examine the synthesis, surface modification, and localization of AuAgNPs to protein targets. We use fluorescein isothiocyanate as a model fluorophore to measure optimal energy transfer conditions. We examine green fluorescent protein as a target protein fluorophore for the protein model. Determination of alloy content, distance control, and targeting abilities for enhanced fluorescence can optimize current fluorescence imaging techniques and quantitative assays with greater sensitivity. Advanced hetero-structure nanoparticles offer added material properties and chemical functionalization over single component nanoparticles. We examine the controlled diagnostic and therapeutic capabilities of the dumbbell-like hetero-structure of gold-iron oxide nanoparticles for targeted in vivo pancreatic cancer MRI enhancement. Advisors/Committee Members: Sun, Shouheng (Director), Kim, Eunsuk (Reader), Webster, Thomas (Reader).

Subjects/Keywords: iron oxide

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Ho, D. N. (2013). Iron Oxide, Gold-Silver Alloy, and Heterostructure Nanoparticles for Magnetic and Optical Theranostic Applications. (Doctoral Dissertation). Brown University. Retrieved from https://repository.library.brown.edu/studio/item/bdr:320491/

Chicago Manual of Style (16^th Edition):

Ho, Don N. “Iron Oxide, Gold-Silver Alloy, and Heterostructure Nanoparticles for Magnetic and Optical Theranostic Applications.” 2013. Doctoral Dissertation, Brown University. Accessed January 23, 2021. https://repository.library.brown.edu/studio/item/bdr:320491/.

MLA Handbook (7^th Edition):

Ho, Don N. “Iron Oxide, Gold-Silver Alloy, and Heterostructure Nanoparticles for Magnetic and Optical Theranostic Applications.” 2013. Web. 23 Jan 2021.

Vancouver:

Ho DN. Iron Oxide, Gold-Silver Alloy, and Heterostructure Nanoparticles for Magnetic and Optical Theranostic Applications. [Internet] [Doctoral dissertation]. Brown University; 2013. [cited 2021 Jan 23]. Available from: https://repository.library.brown.edu/studio/item/bdr:320491/.

Council of Science Editors:

Ho DN. Iron Oxide, Gold-Silver Alloy, and Heterostructure Nanoparticles for Magnetic and Optical Theranostic Applications. [Doctoral Dissertation]. Brown University; 2013. Available from: https://repository.library.brown.edu/studio/item/bdr:320491/

Colorado State University

22. Beck, Lacey. Probing buried defects in zinc oxide nanoparticles using defect-mediated energy transfer.

Degree: MS(M.S.), Chemistry, 2019, Colorado State University

URL: http://hdl.handle.net/10217/197413

► Semiconductor nanocrystals are actively explored as light harvesting materials for solar energy conversion and optoelectronic applications such as solar cells and light emitting diodes. The… (more)

Subjects/Keywords: nanocrystals; energy transfer; zinc oxide

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Beck, L. (2019). Probing buried defects in zinc oxide nanoparticles using defect-mediated energy transfer. (Masters Thesis). Colorado State University. Retrieved from http://hdl.handle.net/10217/197413

Chicago Manual of Style (16^th Edition):

Beck, Lacey. “Probing buried defects in zinc oxide nanoparticles using defect-mediated energy transfer.” 2019. Masters Thesis, Colorado State University. Accessed January 23, 2021. http://hdl.handle.net/10217/197413.

MLA Handbook (7^th Edition):

Beck, Lacey. “Probing buried defects in zinc oxide nanoparticles using defect-mediated energy transfer.” 2019. Web. 23 Jan 2021.

Vancouver:

Beck L. Probing buried defects in zinc oxide nanoparticles using defect-mediated energy transfer. [Internet] [Masters thesis]. Colorado State University; 2019. [cited 2021 Jan 23]. Available from: http://hdl.handle.net/10217/197413.

Council of Science Editors:

Beck L. Probing buried defects in zinc oxide nanoparticles using defect-mediated energy transfer. [Masters Thesis]. Colorado State University; 2019. Available from: http://hdl.handle.net/10217/197413

University of Texas – Austin

23. Agrawal, Ankit, Ph. D. Tunable multiscale infrared plasmonics with metal oxide nanocrystals.

Degree: PhD, Chemical Engineering, 2017, University of Texas – Austin

URL: http://hdl.handle.net/2152/68195

► Degenerately doped semiconductor nanocrystals (NC) exhibit a localized surface plasmon resonance (LSPR) that falls in the near- to mid-IR range of the electromagnetic spectrum. Unlike… (more)

▼ Degenerately doped semiconductor nanocrystals (NC) exhibit a localized surface plasmon resonance (LSPR) that falls in the near- to mid-IR range of the electromagnetic spectrum. Unlike metal, the metal oxide LSPR characteristics can be further tuned by doping, and structural control, or by in situ electrochemical or photochemical charging. Here, we illustrate how intrinsic NC attributes like its crystal structure, shape and size, along with band structure and surface properties affects the LSPR properties and its possible applications. First, the interplay of NC shape and the intrinsic crystal structure on the LSPR was studied using model systems of In:CdO and Cs:WO₃, the latter of which has an intrinsic anisotropic crystal structure. For both systems, a change of shape from spherical to faceted NCs led to as anticipated higher near field enhancements around the particle. However, with Cs:WO₃, presence of an anisotropic hexagonal crystal structure, leads to additional strong LSPR band-splitting into two distinct peaks with comparable intensities. Second, plasmon-molecular vibration coupling, as a proof of concept for sensing applications, was shown using newly developed F and Sn codoped In₂O₃ NCs to couple to the C-H vibration of surface-bound oleate ligands. A combined theoretical and experimental approach was employed to describe the observed plasmon-plasmon coupling, the influence of coupling strength and relative detuning between the molecular vibration and LSPR on the enhancement factor, and the observed Fano lineshape by deconvoluting the combined response of the LSPR and molecular vibration in transmission, absorption, and reflection. Third, plasmon modulation through dynamic carrier density tuning was investigated using thin films of monodisperse ITO NCs with various doping level and sizes along with an in situ electrochemical setup. From the combination of the in-situ spectroelectrochemical analysis and optical modeling, it was found that often-neglected semiconductor properties, such as band structure modification upon doping and surface chemistry, strongly affect the LSPR modulation behavior. The influence of band structure and effects like Fermi level pinning by surface defect states were shown to cause a surface depletion layer that alters the LSPR properties, namely the extent of LSPR modulation, near field enhancement, and sensitivity of the LSPR to the surrounding. Advisors/Committee Members: Milliron, Delia (Delia Jane) (advisor), Goodenough, John B (committee member), Willson, Carlton G (committee member), Truskett, Thomas M (committee member), Krogel, Brian A (committee member).

Subjects/Keywords: Plasmon; Metal oxide; Nanocrystals

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Agrawal, Ankit, P. D. (2017). Tunable multiscale infrared plasmonics with metal oxide nanocrystals. (Doctoral Dissertation). University of Texas – Austin. Retrieved from http://hdl.handle.net/2152/68195

Chicago Manual of Style (16^th Edition):

Agrawal, Ankit, Ph D. “Tunable multiscale infrared plasmonics with metal oxide nanocrystals.” 2017. Doctoral Dissertation, University of Texas – Austin. Accessed January 23, 2021. http://hdl.handle.net/2152/68195.

MLA Handbook (7^th Edition):

Agrawal, Ankit, Ph D. “Tunable multiscale infrared plasmonics with metal oxide nanocrystals.” 2017. Web. 23 Jan 2021.

Vancouver:

Agrawal, Ankit PD. Tunable multiscale infrared plasmonics with metal oxide nanocrystals. [Internet] [Doctoral dissertation]. University of Texas – Austin; 2017. [cited 2021 Jan 23]. Available from: http://hdl.handle.net/2152/68195.

Council of Science Editors:

Agrawal, Ankit PD. Tunable multiscale infrared plasmonics with metal oxide nanocrystals. [Doctoral Dissertation]. University of Texas – Austin; 2017. Available from: http://hdl.handle.net/2152/68195

Northeastern University

24. Gharagouzloo, Codi Amir. Quantitative magnetic resonance imaging with magnetic nanoparticles.

Degree: PhD, Department of Bioengineering, 2016, Northeastern University

URL: http://hdl.handle.net/2047/D20211451

► The ability to measure structural and functional features of health and disease is limited by our current clinical imaging toolbox. For angiography, approximately 1-5 million… (more)

▼ The ability to measure structural and functional features of health and disease is limited by our current clinical imaging toolbox. For angiography, approximately 1-5 million people in the U.S. are not candidates for contrast-enhanced magnetic resonance angiography (CE-MRA) because of renal malfunction. For cancer, it is difficult to predict the extent the enhanced permeability and retention (EPR) effect will be present leading to drug accumulation in tumors. Ferumoxytol has previously been used as a surrogate to assess nanoparticle accumulation, but negative contrast suffers from poor discrimination of nanoparticle localization. For neuroimaging, MRI is a powerful technique for probing the deep brain but can only provide semi-quantitative information. Cerebral blood volume (CBV) is an important indicator of tissue health and function, however current techniques are 15-30% inaccurate, and only the relative CBV is typically measured to assess function. Currently, only nuclear medicine provides an effective means of absolute quantification of contrast agent induced signal. However, the radioisotopes involved in these procedures are hazardous, and thus the use of nuclear medicine is not warranted for repeat structural and functional imaging.; Here we demonstrate a novel technique that can produce CE-MRAs using magnetic nanoparticles including the FDA approved super paramagnetic iron-oxide nanoparticle (SPION) ferumoxytol with very high Contrast to Noise Ratio (CNR) in cardiovascular, cerebral, and tumor imaging in mice and rats. First, the technique is established and shown to measure clinically relevant concentrations of ferumoxytol with high fidelity range in mice. Next, a unique feature of the methodology to produce high-contrast images of purely T1-weighted signal is employed to unambiguously delineate nanoparticle accumulation in a PC3 subcutaneous tumor model with ferumoxytol accumulation 24 hours after just one dose. From this, contrast efficiency was produced compared to standard techniques with the additional benefit that pre-contrast images are not necessitated. Finally, we show unprecedented accuracy in measuring the CBV in absolute terms throughout the whole rat brain. We create a quantitative blood volume atlas and demonstrate that absolute functional measurements of CBV can be assessed by comparing the awake, CO2-challenged and anesthetized states. The method is anchored in theory and is compatible with existing clinical SPION formulations and scanners. Thus QUTE-CE shows high potential for quantitative imaging immediately applicable to human scans.

Subjects/Keywords: ferumoxytol; quantification; superparamagnetic iron oxide nanoparticle (SPION); ultra-short TE (UTE); Magnetic resonance imaging; Nanoparticles; Magnetic properties; Ferric oxide; Therapeutic use; Iron compounds; Therapeutic use; Brain; Tumors; Animal models

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Gharagouzloo, C. A. (2016). Quantitative magnetic resonance imaging with magnetic nanoparticles. (Doctoral Dissertation). Northeastern University. Retrieved from http://hdl.handle.net/2047/D20211451

Chicago Manual of Style (16^th Edition):

Gharagouzloo, Codi Amir. “Quantitative magnetic resonance imaging with magnetic nanoparticles.” 2016. Doctoral Dissertation, Northeastern University. Accessed January 23, 2021. http://hdl.handle.net/2047/D20211451.

MLA Handbook (7^th Edition):

Gharagouzloo, Codi Amir. “Quantitative magnetic resonance imaging with magnetic nanoparticles.” 2016. Web. 23 Jan 2021.

Vancouver:

Gharagouzloo CA. Quantitative magnetic resonance imaging with magnetic nanoparticles. [Internet] [Doctoral dissertation]. Northeastern University; 2016. [cited 2021 Jan 23]. Available from: http://hdl.handle.net/2047/D20211451.

Council of Science Editors:

Gharagouzloo CA. Quantitative magnetic resonance imaging with magnetic nanoparticles. [Doctoral Dissertation]. Northeastern University; 2016. Available from: http://hdl.handle.net/2047/D20211451

RMIT University

25. Arora, J. The synthesis and application of iron oxide nanoparticles for targeted imaging using MRI.

Degree: 2011, RMIT University

URL: http://researchbank.rmit.edu.au/view/rmit:161634

► The work presented in this PhD describes the use of highly magnetic iron oxide silica nanoparticles conjugated to herceptin for the targeted detection of human… (more)

Subjects/Keywords: Fields of Research; MRI; Magnetic resonance imaging; Iron oxide nanoparticles; Targeted imaging

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Arora, J. (2011). The synthesis and application of iron oxide nanoparticles for targeted imaging using MRI. (Thesis). RMIT University. Retrieved from http://researchbank.rmit.edu.au/view/rmit:161634

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Arora, J. “The synthesis and application of iron oxide nanoparticles for targeted imaging using MRI.” 2011. Thesis, RMIT University. Accessed January 23, 2021. http://researchbank.rmit.edu.au/view/rmit:161634.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Arora, J. “The synthesis and application of iron oxide nanoparticles for targeted imaging using MRI.” 2011. Web. 23 Jan 2021.

Vancouver:

Arora J. The synthesis and application of iron oxide nanoparticles for targeted imaging using MRI. [Internet] [Thesis]. RMIT University; 2011. [cited 2021 Jan 23]. Available from: http://researchbank.rmit.edu.au/view/rmit:161634.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Arora J. The synthesis and application of iron oxide nanoparticles for targeted imaging using MRI. [Thesis]. RMIT University; 2011. Available from: http://researchbank.rmit.edu.au/view/rmit:161634

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of California – Riverside

26. Daya, Radha. Hyaluronic Acid Hydrogels Loaded with Curcumin-Coated Magnetic Nanoparticles for Angiogenesis in Bone Tissue Engineering.

Degree: Bioengineering, 2017, University of California – Riverside

URL: http://www.escholarship.org/uc/item/6q9451qs

► Tissue engineering, the combination of cells, scaffolding materials, and biochemical signals is being extensively researched for tissue generation and regeneration. The potential to generate tissue… (more)

Subjects/Keywords: Biomedical engineering; Angiogenesis; Bone Marrow Stromal Cells; Curcumin; Iron Oxide (Fe3O4); Magnetic Nanoparticles; Tissue Engineering

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Daya, R. (2017). Hyaluronic Acid Hydrogels Loaded with Curcumin-Coated Magnetic Nanoparticles for Angiogenesis in Bone Tissue Engineering. (Thesis). University of California – Riverside. Retrieved from http://www.escholarship.org/uc/item/6q9451qs

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Daya, Radha. “Hyaluronic Acid Hydrogels Loaded with Curcumin-Coated Magnetic Nanoparticles for Angiogenesis in Bone Tissue Engineering.” 2017. Thesis, University of California – Riverside. Accessed January 23, 2021. http://www.escholarship.org/uc/item/6q9451qs.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Daya, Radha. “Hyaluronic Acid Hydrogels Loaded with Curcumin-Coated Magnetic Nanoparticles for Angiogenesis in Bone Tissue Engineering.” 2017. Web. 23 Jan 2021.

Vancouver:

Daya R. Hyaluronic Acid Hydrogels Loaded with Curcumin-Coated Magnetic Nanoparticles for Angiogenesis in Bone Tissue Engineering. [Internet] [Thesis]. University of California – Riverside; 2017. [cited 2021 Jan 23]. Available from: http://www.escholarship.org/uc/item/6q9451qs.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Daya R. Hyaluronic Acid Hydrogels Loaded with Curcumin-Coated Magnetic Nanoparticles for Angiogenesis in Bone Tissue Engineering. [Thesis]. University of California – Riverside; 2017. Available from: http://www.escholarship.org/uc/item/6q9451qs

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

27. Campbell, Scott Brice. ’Smart’, Injectable, Magnetic Nanocomposite Hydrogels for Biomedical Applications with a Focus on Externally-Mediated Release.

Degree: PhD, 2017, McMaster University

URL: http://hdl.handle.net/11375/20953

►

The capability of precisely controlling the kinetics of therapeutic delivery at the optimal location and rate for a given patient would have great potential to… (more)

▼

The capability of precisely controlling the kinetics of therapeutic delivery at the optimal location and rate for a given patient would have great potential to improve health and well-being in a range of current drug therapies (insulin, chemotherapeutics, vaccines, etc.). Indeed, if successfully developed, locally administered injectable drug delivery vehicles capable of remotely-triggered release would be the gold standard for many treatments. Multiple injectable nanocomposites have been investigated for this purpose that are generally comprised of a thermosensitive polymeric material and superparamagnetic iron oxide nanoparticles (SPIONs). SPIONs generate heat when exposed remote alternating magnetic fields (AMFs), and the transfer of this heat to thermosensitive polymers can be used to control the release of therapeutics. Ideally, these systems would be capable of returning to their original state and basal release rate when the external AMF trigger is removed. Several novel injectable nanocomposite materials that explore interactions between SPIONs and thermosensitive polymers to mediate drug release, from the macroscale to the nanoscale, were developed and demonstrated to be capable of remotely-triggered, AMF-mediated enhanced release. The macroscale magnetic nanocomposites have thermosensitive hydrogel and/or microgel components that regulate release based on the heat produced from SPIONs in response to an external AMF. On the millimeter-scale, a microinjection system capable of producing thermosensitive hydrogel beads that could potentially incorporate SPIONs is described. On the nanoscale, nanoparticles with a glass transition temperature and thermosensitive microgels are combined with SPIONs and investigated for their remote, AMF-mediated release characteristics. The engineered macroscale and nanoscale systems are capable of up to ~4:1 and ~7:1 enhancements in release due to an AMF application, respectively, compared to the basal release rate. Collectively, these nanocomposites represent a promising stride towards improved remote-actuation of drug release and a stepping stone for future attempts at precisely controlling the site and kinetics of drug release.

Thesis

Doctor of Philosophy (PhD)

This thesis focuses on the development of nanocomposite materials that can be injected into a specific location in the body and deliver therapeutic drugs by a remote-controlled process. These nanocomposites are composed of magnetic particles and polymers that respond to changes in temperature. The combination of these materials results in nanocomposites that can change their properties in response to specific magnetic fields to switch from releasing drug slowly (or not at all) to releasing drug quickly on demand. The changes are fully reversible and solely depend on whether the external magnetic field is switched on or off. These novel systems offer an alternative to therapies that require frequent injections, such as insulin for diabetes, or therapies that need the drug to be released in very…

Advisors/Committee Members: Hoare, Todd, Chemical Engineering.

Subjects/Keywords: drug delivery; remote controlled release; hydrogels; microgels; iron oxide nanoparticles; microinjector; magnetic

10 more images…

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Campbell, S. B. (2017). ’Smart’, Injectable, Magnetic Nanocomposite Hydrogels for Biomedical Applications with a Focus on Externally-Mediated Release. (Doctoral Dissertation). McMaster University. Retrieved from http://hdl.handle.net/11375/20953

Chicago Manual of Style (16^th Edition):

Campbell, Scott Brice. “’Smart’, Injectable, Magnetic Nanocomposite Hydrogels for Biomedical Applications with a Focus on Externally-Mediated Release.” 2017. Doctoral Dissertation, McMaster University. Accessed January 23, 2021. http://hdl.handle.net/11375/20953.

MLA Handbook (7^th Edition):

Campbell, Scott Brice. “’Smart’, Injectable, Magnetic Nanocomposite Hydrogels for Biomedical Applications with a Focus on Externally-Mediated Release.” 2017. Web. 23 Jan 2021.

Vancouver:

Campbell SB. ’Smart’, Injectable, Magnetic Nanocomposite Hydrogels for Biomedical Applications with a Focus on Externally-Mediated Release. [Internet] [Doctoral dissertation]. McMaster University; 2017. [cited 2021 Jan 23]. Available from: http://hdl.handle.net/11375/20953.

Council of Science Editors:

Campbell SB. ’Smart’, Injectable, Magnetic Nanocomposite Hydrogels for Biomedical Applications with a Focus on Externally-Mediated Release. [Doctoral Dissertation]. McMaster University; 2017. Available from: http://hdl.handle.net/11375/20953

28. Li, Jie. War against biofilms: magnetic nanoparticles as effective shield breakers.

Degree: Biosystems Engineering, 2018, University of Manitoba

URL: http://hdl.handle.net/1993/33310

► Biofilm formation on medical devices can cause persistent infections. The main feature of biofilms is their self-produced extracellular polymeric substances (EPS) that act as a… (more)

Subjects/Keywords: Biofilm; Iron-oxide magnetic nanoparticles

…used [60]. 1.3. Iron-oxide Magnetic Nanoparticles The efficient treatment of… …devices and implants [61]. Recently, iron oxide magnetic nanoparticles (MNPs)… …properties, and simple separation methodology, magnetic iron oxide (Fe3O4 and γ-Fe2O3)… …x5D;. 1.3.2. Surface coating of Iron-oxide magnetic nanoparticles Stabilization of the… …treatment. Figure 8. The biofilms were treated with 2 mL 30 mg/mL of different sizes iron-oxide…

10 more images…

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Li, J. (2018). War against biofilms: magnetic nanoparticles as effective shield breakers. (Masters Thesis). University of Manitoba. Retrieved from http://hdl.handle.net/1993/33310

Chicago Manual of Style (16^th Edition):

Li, Jie. “War against biofilms: magnetic nanoparticles as effective shield breakers.” 2018. Masters Thesis, University of Manitoba. Accessed January 23, 2021. http://hdl.handle.net/1993/33310.

MLA Handbook (7^th Edition):

Li, Jie. “War against biofilms: magnetic nanoparticles as effective shield breakers.” 2018. Web. 23 Jan 2021.

Vancouver:

Li J. War against biofilms: magnetic nanoparticles as effective shield breakers. [Internet] [Masters thesis]. University of Manitoba; 2018. [cited 2021 Jan 23]. Available from: http://hdl.handle.net/1993/33310.

Council of Science Editors:

Li J. War against biofilms: magnetic nanoparticles as effective shield breakers. [Masters Thesis]. University of Manitoba; 2018. Available from: http://hdl.handle.net/1993/33310

29. Bitar, Ahmad. Élaboration de la silice magnétique colloïdale pour application en biologie moléculaire : extraction des acides nucléiques : Preparation of colloidal silica magnetic particles for molecular biology application : nucleic acids extraction.

Degree: Docteur es, Chimie, 2013, Université Claude Bernard – Lyon I

URL: http://www.theses.fr/2013LYO10115

►

Le diagnostic moléculaire est un diagnostic basé sur l’analyse des acides nucléiques nécessite incontestablement la préparation d’échantillon. Cette préparation à pour objectif d’extraire des acides… (more)

▼

Le diagnostic moléculaire est un diagnostic basé sur l’analyse des acides nucléiques nécessite incontestablement la préparation d’échantillon. Cette préparation à pour objectif d’extraire des acides nucléiques d’un milieu généralement très complexe, de les purifier, de les concentrer voir les transporter dans des microsystèmes utilisés comme outils de diagnostic. Aujourd’hui, l’utilisation de nouvelles technologies et en particulier l’utilisation de supports solides ont permis de palier à un grand nombre de problèmes comparé aux méthodes conventionnelles. L’évolution de ces supports solides en particules colloïdales a permis de répondre à la demande des nouvelles technologies en apportant, une grande surface spécifique, une séparation rapide suite au caractère magnétique, un transport simple dans les microsystèmes et une chimie de surface modulable pour une bonne extraction de l’analyte recherchée. Ainsi, l’objet de cette étude est la synthèse de la silice magnétique submicronique en taille pour l’extraction des acides nucléiques. La synthèse de la silice magnétique a été conduite en trois étapes. Dans un premier temps, la synthèse de ferrofluide organique a été réalisée par coprécipitation des chlorures ferriques et ferreux en basic avant transfert en milieu organique. La deuxième étape a été la préparation d’émulsions magnétiques stables, fortement magnétiques (pour une séparation rapide) et de taille relativement homogène et reproductible. Le ferrofluide préparé organique préparé a été émulsionné pour préparer une émulsion huile dans l’eau (O/W) en utilisant un tensioactif anionique. L’émulsion magnétique a été ensuite encapsulée par une écorce de silice via le procédé sol-gel. Le procédé d’encapsulation a été optimisé via une étude systématique et par une caractérisation physicochimie et colloïdale complète de particules. La caractérisation morphologique des particules obtenues a montré une structure coeur magnétique et une écorce de silice parfaitement homogène. Ces particules de silice magnétique ont été utilisées pour étudier l’adsorption des acides nucléiques (fragment d’ADN) en fonction du pH et de la salinité. Les résultats montrent une bonne capacité d’adsorption des acides nucléiques et également un bon relargage. Ce résultat encourageant montre que ces particules peuvent être utilisées dans le diagnostic moléculaire où l’extraction, la purification et la concentration des acides nucléiques sont très recherchées

Currently, the genetics and DNA-based applications are developing very vast. All these applications such as gene therapy, diagnosis and PCR (polymerase chain reaction) require a previous step, which is the isolation and purification of genetic materials from their compartment. Taking care that the extraction method should produce the DNA in high purification state and in good conditions. The DNA extraction and purification are well known from long time ago, but these methods are time and organic solvents consuming. Nowadays, new nanotechnology-based techniques allow establishing rapid,…

Advisors/Committee Members: Elaissari, Abdelhamid (thesis director), Fessi, Hatem (thesis director).

Subjects/Keywords: Nanoparticules; Magnétique; Sol-Gel; Oxyde de fer; Nanoparticles; Magnetic; Sol gel process; Iron oxide; 570

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Bitar, A. (2013). Élaboration de la silice magnétique colloïdale pour application en biologie moléculaire : extraction des acides nucléiques : Preparation of colloidal silica magnetic particles for molecular biology application : nucleic acids extraction. (Doctoral Dissertation). Université Claude Bernard – Lyon I. Retrieved from http://www.theses.fr/2013LYO10115

Chicago Manual of Style (16^th Edition):

Bitar, Ahmad. “Élaboration de la silice magnétique colloïdale pour application en biologie moléculaire : extraction des acides nucléiques : Preparation of colloidal silica magnetic particles for molecular biology application : nucleic acids extraction.” 2013. Doctoral Dissertation, Université Claude Bernard – Lyon I. Accessed January 23, 2021. http://www.theses.fr/2013LYO10115.

MLA Handbook (7^th Edition):

Bitar, Ahmad. “Élaboration de la silice magnétique colloïdale pour application en biologie moléculaire : extraction des acides nucléiques : Preparation of colloidal silica magnetic particles for molecular biology application : nucleic acids extraction.” 2013. Web. 23 Jan 2021.

Vancouver:

Bitar A. Élaboration de la silice magnétique colloïdale pour application en biologie moléculaire : extraction des acides nucléiques : Preparation of colloidal silica magnetic particles for molecular biology application : nucleic acids extraction. [Internet] [Doctoral dissertation]. Université Claude Bernard – Lyon I; 2013. [cited 2021 Jan 23]. Available from: http://www.theses.fr/2013LYO10115.

Council of Science Editors:

Bitar A. Élaboration de la silice magnétique colloïdale pour application en biologie moléculaire : extraction des acides nucléiques : Preparation of colloidal silica magnetic particles for molecular biology application : nucleic acids extraction. [Doctoral Dissertation]. Université Claude Bernard – Lyon I; 2013. Available from: http://www.theses.fr/2013LYO10115

30. M. Galli. SYNTHESIS OF MAGNETIC AND OPTICAL NANOMETRIC PROBES FOR THERANOSTIC APPLICATIONS.

Degree: 2018, Università degli Studi di Milano

URL: http://hdl.handle.net/2434/547258

► The aim of this Ph.D thesis is the development of new nanometric compounds that could find possible theranostic applications in the field of nanomedicine. To… (more)

▼ The aim of this Ph.D thesis is the development of new nanometric compounds that could find possible theranostic applications in the field of nanomedicine. To this end different multimodal agents, based on magnetic iron oxide nanoparticles or poly(amidoamine)s were synthesized and characterized. To this aim we first synthesized a new luminescent metallopolymer for photodynamic therapy (PDT), based on an amphoteric and biocompatible polyamidoamine, PhenISA, to which a new organometallic Ir complex was conjugated. This polymer was able to self-assemble into nanoparticle while the Ir complex could, upon light absorption, give rise to triplet metal to ligand charge transfer excited states that can both radiatively decay, providing optical luminescence, or react with 3O2, producing cytotoxic reactive oxygen species, allowing for both imaging and PDT applications. These properties were tested by cell uptake assays and prelaminar cytotoxicity studies. Poly(amidoamine)s functionalized with different metal complexes (namely Ru and Pt) were also investigated (Chapter 1). We then prepared a new magneto-optical probes and sensitizers for photodynamic therapy. This bimodal probe was constituted by a magnetic iron oxide core and a silica shell grafted with a luminescent Re complex, acting as both optical emitter and PDT sensitizer. The silica shell was also coated by a poly(ethyleneglycol) layer to reduce the toxicity and improve the colloidal stability of the nanoprobe. The nanocomposite photophysical properties were then tested, and the cellular uptake and light-activated cytotoxicity were subsequently characterized on HeLa cells (Chapter 2). As a next work we presented a new strategy to bind peptide nucleic acids (PNA) onto the surface of iron oxide nanoparticles, that could find future application in combining the nanoparticle magnetic properties with the PNA specific targeting ability. Two different synthetic pathways were investigated, and an extensive magnetic characterization was performed to check for any influence of the conjugation strategy on the nanoparticles initial magnetic properties (Chapter 3). During my abroad period in EMPA St.gallen (CH) I worked on the possible application of magnetic nanoparticle for blood purification applications. We first developed a proof of concept study on the theranostic potential of magnetic blood purification applied to sepsis using. Bacterial removal could not only directly improve the condition of sepsis-ill patients but also help in decreasing the time needed for effective diagnosis and treatment. To this end we used commercial magnetic nanoparticles functionalized with newly developed human IgG1 monoclonal antibody against poly-N-acetylglucosamine (PNAG), a key component of the bacterial cell wall. We investigated both the nanoparticles magnetic separation efficiency and degradation properties, as well as their biocompatibility and bacteria removal capability (Chapter 4). We then synthesized hydrophobic iron oxide and iron carbide nanoparticles that were subjected to… Advisors/Committee Members: tutor: D. Maggioni, coordinator: M. Pizzotti, PIZZOTTI, MADDALENA, MAGGIONI, DANIELA.

Subjects/Keywords: magnetic nanoparticles; iron oxide nanoparticles; photodynamic therapy; polyamidoamine; Settore CHIM/03 - Chimica Generale e Inorganica

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Galli, M. (2018). SYNTHESIS OF MAGNETIC AND OPTICAL NANOMETRIC PROBES FOR THERANOSTIC APPLICATIONS. (Thesis). Università degli Studi di Milano. Retrieved from http://hdl.handle.net/2434/547258

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Galli, M.. “SYNTHESIS OF MAGNETIC AND OPTICAL NANOMETRIC PROBES FOR THERANOSTIC APPLICATIONS.” 2018. Thesis, Università degli Studi di Milano. Accessed January 23, 2021. http://hdl.handle.net/2434/547258.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Galli, M.. “SYNTHESIS OF MAGNETIC AND OPTICAL NANOMETRIC PROBES FOR THERANOSTIC APPLICATIONS.” 2018. Web. 23 Jan 2021.

Vancouver:

Galli M. SYNTHESIS OF MAGNETIC AND OPTICAL NANOMETRIC PROBES FOR THERANOSTIC APPLICATIONS. [Internet] [Thesis]. Università degli Studi di Milano; 2018. [cited 2021 Jan 23]. Available from: http://hdl.handle.net/2434/547258.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Galli M. SYNTHESIS OF MAGNETIC AND OPTICAL NANOMETRIC PROBES FOR THERANOSTIC APPLICATIONS. [Thesis]. Università degli Studi di Milano; 2018. Available from: http://hdl.handle.net/2434/547258

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

		in
And / Or
		in
And / Or
		in
And / Or
		in

Open Access Theses and Dissertations