subject:(Macromolecule)

1. Piguet, Fabien. Etude théorique et expérimentale de la translocation de macromolécules à travers un nanopore : Theoretical and experimental study of the translocation of macromolecules through nanopores.

Degree: Docteur es, Physique - Cergy, 2014, Cergy-Pontoise

URL: http://www.theses.fr/2014CERG0728

► La translocation, le passage d'une macromolécule à travers un pore inséré dans une membrane, est impliquée dans de nombreux processus biologiques. On peut citer comme… (more)

▼ La translocation, le passage d'une macromolécule à travers un pore inséré dans une membrane, est impliquée dans de nombreux processus biologiques. On peut citer comme exemple le transport d'ARN ou de protéines entre les composants de la cellule, et l'infection d'une cellule par le passage d'un ADN viral à travers la membrane cellulaire. Aujourd'hui la translocation est aussi la base d'applications technologiques, comme le fait d'utiliser les pores en tant que détecteurs pour le séquençage rapide de molécules ou en tant que filtre moléculaire. La compréhension du processus de translocation est importante à la fois d'un point de vue fondamental et pour la fabrication de nouveaux dispositifs de translocation à usage spécifique. Dans cette thèse, nous réalisons des expériences et des simulations informatiques pour étudier certains des effets les plus importants mis en jeu lors de la translocation.Nous utilisons des simulations informatiques avec un modèle à ``gros grain'' pour étudier qualitativement l'influence d'une interaction attractive entre les parois du pore et un polymère en train de transloquer. Nous montrons que la position de l'interaction influence la fréquence d'entrée et le temps de résidence du polymère dans le pore. La fréquence d'entrée est plus grande lorsque l'entrée du pore est attractive. Le comportement du temps de résidence avec la longueur du polymère est qualitativement et quantitativement affecté par la position de l'interaction dans le pore. Cependant, quelle que soit la position de l'interaction, nous observons que le temps de translocation augmente linéairement avec la longueur du polymère lorsque le polymère est plus long que le pore. Cette observation est qualitativement en accord avec des données expérimentales publiées.Lorsque la translocation est lente, la corrélation entre les mouvements des monomères confinés dans le pore peut jouer un rôle important. Cet effet n'a pas été pris en compte jusqu'à présent. Nous développons un nouveau modèle pour la translocation de polymères, inspiré par le processus d'exclusion asymétrique (ASEP process), qui permet d'étudier spécifiquement cet effet. Nous montrons que les mouvements corrélés des monomères confinés dans le pore génèrent un comportement du temps de résidence avec la longueur du polymère qui est qualitativement similaire à ce qui est habituellement interprété comme la présence d'une barrière d'énergie libre dans le processus de translocation, même lorsqu'une telle barrière n'existe pas. Notre modèle réduit fortement le temps de simulation comparé aux simulations de dynamique moléculaire traditionnelles (quelques secondes contre quelques mois pour un système similaire). Cette accélération provient de l'idéalisation des portions du polymère à l'extérieur du pore. Une telle idéalisation est également présente dans les modèles largement utlisés de type Fokker-Planck, mais dans notre cas le comportement de la partie de la chaîne confinée dans le pore est mieux modélisé.Enfin nous réalisons des expériences pour tester l'existence d'un flot… Advisors/Committee Members: Foster, Damien Paul (thesis director), Oukhaled, Abdelghani (thesis director).

Subjects/Keywords: Translocation; Macromolécule; Nanopore; Translocation; Macromolecule; Nanopore

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APA (6^th Edition):

Piguet, F. (2014). Etude théorique et expérimentale de la translocation de macromolécules à travers un nanopore : Theoretical and experimental study of the translocation of macromolecules through nanopores. (Doctoral Dissertation). Cergy-Pontoise. Retrieved from http://www.theses.fr/2014CERG0728

Chicago Manual of Style (16^th Edition):

Piguet, Fabien. “Etude théorique et expérimentale de la translocation de macromolécules à travers un nanopore : Theoretical and experimental study of the translocation of macromolecules through nanopores.” 2014. Doctoral Dissertation, Cergy-Pontoise. Accessed March 08, 2021. http://www.theses.fr/2014CERG0728.

MLA Handbook (7^th Edition):

Piguet, Fabien. “Etude théorique et expérimentale de la translocation de macromolécules à travers un nanopore : Theoretical and experimental study of the translocation of macromolecules through nanopores.” 2014. Web. 08 Mar 2021.

Vancouver:

Piguet F. Etude théorique et expérimentale de la translocation de macromolécules à travers un nanopore : Theoretical and experimental study of the translocation of macromolecules through nanopores. [Internet] [Doctoral dissertation]. Cergy-Pontoise; 2014. [cited 2021 Mar 08]. Available from: http://www.theses.fr/2014CERG0728.

Council of Science Editors:

Piguet F. Etude théorique et expérimentale de la translocation de macromolécules à travers un nanopore : Theoretical and experimental study of the translocation of macromolecules through nanopores. [Doctoral Dissertation]. Cergy-Pontoise; 2014. Available from: http://www.theses.fr/2014CERG0728

Bucknell University

2. McFadden, Benjamin. Synthesis Of Triblock Copolymers By Radical Trap Assisted-Atom Transfer Radical Coupling.

Degree: 2013, Bucknell University

URL: https://digitalcommons.bucknell.edu/masters_theses/101

► Monobrominated diblock copolymers composed of poly(styrene) (PSt), poly(methylacrylate) (PMA), or poly(methyl methacrylate) (PMMA) were synthesized by consecutive atom transfer radical polymerizations (ATRP). The brominated diblocks… (more)

Subjects/Keywords: triblock; polymer; macromolecule; ATRP; ATRC; RTA-ATRC

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APA (6^th Edition):

McFadden, B. (2013). Synthesis Of Triblock Copolymers By Radical Trap Assisted-Atom Transfer Radical Coupling. (Thesis). Bucknell University. Retrieved from https://digitalcommons.bucknell.edu/masters_theses/101

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

McFadden, Benjamin. “Synthesis Of Triblock Copolymers By Radical Trap Assisted-Atom Transfer Radical Coupling.” 2013. Thesis, Bucknell University. Accessed March 08, 2021. https://digitalcommons.bucknell.edu/masters_theses/101.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

McFadden, Benjamin. “Synthesis Of Triblock Copolymers By Radical Trap Assisted-Atom Transfer Radical Coupling.” 2013. Web. 08 Mar 2021.

Vancouver:

McFadden B. Synthesis Of Triblock Copolymers By Radical Trap Assisted-Atom Transfer Radical Coupling. [Internet] [Thesis]. Bucknell University; 2013. [cited 2021 Mar 08]. Available from: https://digitalcommons.bucknell.edu/masters_theses/101.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

McFadden B. Synthesis Of Triblock Copolymers By Radical Trap Assisted-Atom Transfer Radical Coupling. [Thesis]. Bucknell University; 2013. Available from: https://digitalcommons.bucknell.edu/masters_theses/101

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

3. Locke, Ian Wyn. Preparation and computational study of novel fullerene intercalation compounds.

Degree: PhD, 1999, University of Sussex

URL: https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.299956

Subjects/Keywords: 546; Phosphorus; Macromolecule

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APA (6^th Edition):

Locke, I. W. (1999). Preparation and computational study of novel fullerene intercalation compounds. (Doctoral Dissertation). University of Sussex. Retrieved from https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.299956

Chicago Manual of Style (16^th Edition):

Locke, Ian Wyn. “Preparation and computational study of novel fullerene intercalation compounds.” 1999. Doctoral Dissertation, University of Sussex. Accessed March 08, 2021. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.299956.

MLA Handbook (7^th Edition):

Locke, Ian Wyn. “Preparation and computational study of novel fullerene intercalation compounds.” 1999. Web. 08 Mar 2021.

Vancouver:

Locke IW. Preparation and computational study of novel fullerene intercalation compounds. [Internet] [Doctoral dissertation]. University of Sussex; 1999. [cited 2021 Mar 08]. Available from: https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.299956.

Council of Science Editors:

Locke IW. Preparation and computational study of novel fullerene intercalation compounds. [Doctoral Dissertation]. University of Sussex; 1999. Available from: https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.299956

University of Florida

4. Sims, Michael B. Leveraging Imine Chemistry to Design Dynamic Macromolecules at the Residual, Microstructural, and Topological Scale.

Degree: PhD, Chemistry, 2019, University of Florida

URL: https://ufdc.ufl.edu/UFE0055978

► The reversibility of imine chemistry makes it a powerful tool for the precise construction and deconstruction of macromolecules. In the work presented in this dissertation,… (more)

Subjects/Keywords: dynamic – hyperbranched – imine – macromolecule – polymer – polymerization

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APA (6^th Edition):

Sims, M. B. (2019). Leveraging Imine Chemistry to Design Dynamic Macromolecules at the Residual, Microstructural, and Topological Scale. (Doctoral Dissertation). University of Florida. Retrieved from https://ufdc.ufl.edu/UFE0055978

Chicago Manual of Style (16^th Edition):

Sims, Michael B. “Leveraging Imine Chemistry to Design Dynamic Macromolecules at the Residual, Microstructural, and Topological Scale.” 2019. Doctoral Dissertation, University of Florida. Accessed March 08, 2021. https://ufdc.ufl.edu/UFE0055978.

MLA Handbook (7^th Edition):

Sims, Michael B. “Leveraging Imine Chemistry to Design Dynamic Macromolecules at the Residual, Microstructural, and Topological Scale.” 2019. Web. 08 Mar 2021.

Vancouver:

Sims MB. Leveraging Imine Chemistry to Design Dynamic Macromolecules at the Residual, Microstructural, and Topological Scale. [Internet] [Doctoral dissertation]. University of Florida; 2019. [cited 2021 Mar 08]. Available from: https://ufdc.ufl.edu/UFE0055978.

Council of Science Editors:

Sims MB. Leveraging Imine Chemistry to Design Dynamic Macromolecules at the Residual, Microstructural, and Topological Scale. [Doctoral Dissertation]. University of Florida; 2019. Available from: https://ufdc.ufl.edu/UFE0055978

5. Recht, Raphaël. Mise au point de méthodes de détection d’interaction ligand-macromolécule par RMN du 19F : Setting up a method to detect ligand-macromolecule interaction through 19F NMR.

Degree: Docteur es, Biophysique et biologie structurale, 2016, Université de Strasbourg

URL: http://www.theses.fr/2016STRAJ055

►

Les interactions biologiques sont régies par des mécanismes complexes, qui mêlent différentes échelles, de temps comme de taille. C’est le cas du ribosome, un complexe… (more)

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Les interactions biologiques sont régies par des mécanismes complexes, qui mêlent différentes échelles, de temps comme de taille. C’est le cas du ribosome, un complexe nucléoprotéique responsable de la traduction de l’ARNm en protéines, et ce faisant, une cible thérapeutique primordiale. Or la taille du ribosome procaryote 70S (2.4 MDa) rend difficile l’applications des techniques classiques de criblage de ligands. Au cours de ma thèse, j’ai exploré la possibilité d’utiliser la RMN du fluor pour caractériser les interactions entre des ligands et le ribosome procaryote. Cette approche a été motivée par l’apport de nouvelles méthodes de détection pouvant coupler la versatilité de la RMN (Résonance Magnétique Nucléaire) avec les propriétés de l’atome de fluor. L’atome 19F se prête parfaitement à la RMN, avec son rapport gyromagnétique proche du proton et son abondance isotopique naturelle de 100%. De plus, le fluor est bio-orthogonal au Vivant. Enfin, les caractéristiques physico-chimiques du fluor sont bien exploitées dans la pharmacopée (un quart des antibiotiques en possèdent un groupement).

Biological interactions are under the control of complex mechanisms, across different scales, in time of in size. It is particularly true for the ribosome, a nucleoprotein responsible for the mRNA translation into proteins, and thus, a primary therapeutic target. The size of the prokaryotic 70S ribosome (2.4 MDa) is a problem for the application of classical ligand screening method. During my thesis, I explored using fluorine NMR to characterize the interaction between ligands and the prokaryotic ribosome. This strategy was motivated by new detection approaches that can combine NMR (Nuclear Magnetic Resonance) versatility with the fluorine atom properties. The 19F atom is perfectly suited for NMR, with its gyromagnetic ratio close to the proton one and its isotopic abundance of 100%. Moreover, the fluorine is absent from natural compounds. Finally, the physicochemical characteristics of fluorine are well exploited in the pharmacopeia (a fourth of all antibiotics has a fluorine moiety).

Advisors/Committee Members: Kieffer, Bruno (thesis director), Yusupov, Marat (thesis director).

Subjects/Keywords: RMN; Fluor; Criblage; Interaction; Ligand; Macromolecule; Ribosome; NMR; Fluorine; Screening; Interaction; Ligand; Macromolecule; Ribosome; 571.4

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APA (6^th Edition):

Recht, R. (2016). Mise au point de méthodes de détection d’interaction ligand-macromolécule par RMN du 19F : Setting up a method to detect ligand-macromolecule interaction through 19F NMR. (Doctoral Dissertation). Université de Strasbourg. Retrieved from http://www.theses.fr/2016STRAJ055

Chicago Manual of Style (16^th Edition):

Recht, Raphaël. “Mise au point de méthodes de détection d’interaction ligand-macromolécule par RMN du 19F : Setting up a method to detect ligand-macromolecule interaction through 19F NMR.” 2016. Doctoral Dissertation, Université de Strasbourg. Accessed March 08, 2021. http://www.theses.fr/2016STRAJ055.

MLA Handbook (7^th Edition):

Recht, Raphaël. “Mise au point de méthodes de détection d’interaction ligand-macromolécule par RMN du 19F : Setting up a method to detect ligand-macromolecule interaction through 19F NMR.” 2016. Web. 08 Mar 2021.

Vancouver:

Recht R. Mise au point de méthodes de détection d’interaction ligand-macromolécule par RMN du 19F : Setting up a method to detect ligand-macromolecule interaction through 19F NMR. [Internet] [Doctoral dissertation]. Université de Strasbourg; 2016. [cited 2021 Mar 08]. Available from: http://www.theses.fr/2016STRAJ055.

Council of Science Editors:

Recht R. Mise au point de méthodes de détection d’interaction ligand-macromolécule par RMN du 19F : Setting up a method to detect ligand-macromolecule interaction through 19F NMR. [Doctoral Dissertation]. Université de Strasbourg; 2016. Available from: http://www.theses.fr/2016STRAJ055

North Carolina State University

6. Walker, Teri Anne. Modification of Polymer Blend Phase Behavior with High-Pressure Carbon Dioxide.

Degree: PhD, Chemical Engineering, 2003, North Carolina State University

URL: http://www.lib.ncsu.edu/resolver/1840.16/4080

► While much progress has been made since the time of Flory and Huggins in the understanding of polymer blend thermodynamics, and ongoing research continues to… (more)

▼ While much progress has been made since the time of Flory and Huggins in the understanding of polymer blend thermodynamics, and ongoing research continues to elucidate how polymer blend phase behavior is affected by the presence of small-molecule solvents or exposure to elevated pressures, very little work has been reported on the combined effects of a pressurized small-molecule solvent on polymer blend phase behavior. The focus of this research is to improve the current state of fundamental understanding regarding how and why the phase behavior of polymer blends changes as pressurized carbon dioxide (CO₂) is added. The first part of this work provides a broad overview of previous efforts that explore various thermodynamic and kinetic processes involving the use of CO₂ in conjunction with multicomponent polymer systems. The following chapters discuss details of research performed primarily on three blend systems: polystyrene (PS)/polyisoprene (PI), poly(vinylidene fluoride) (PVDF)/ poly(methyl methacrylate) (PMMA), and polydimethylsiloxane (PDMS)/poly(ethylmethylsiloxane) (PEMS). The competing roles of hydrostatic pressure and CO₂ dissolution on the phase behavior of both the PS/PI and the PDMS/PEMS blends, which exhibit upper critical solution temperature (UCST) behavior, are systematically established. Additionally, a complete pseudo-binary temperature-composition phase diagram of the PDMS/PEMS blend is generated as a function of CO₂ pressure. To compare the predictive abilities of the Flory-Huggins and Sanchez-Lacombe equations of state, interaction parameters of the PDMS/PEMS blend are predicted as functions of temperature and CO₂ pressure. The phase behavior of, as well as intermolecular interactions in, PMMA/PVDF blends have been probed in the presence of CO₂ by small-angle neutron and x-ray scattering (SANS and SAXS, respectively). These PMMA/PVDF blends, which display both UCST and lower critical solution temperature (LCST) behavior, are also characterized before and after exposure to CO₂ by transmission electron microscopy and differential scanning calorimetry, which together confirm the propensity for CO₂-induced PVDF crystallization. Advisors/Committee Members: Saad A. Khan, Committee Co-Chair (advisor), Jan Genzer, Committee Member (advisor), Joseph M. DeSimone, Committee Member (advisor), Richard J. Spontak, Committee Chair (advisor).

Subjects/Keywords: specrophotometry; miscibility; cloud curve; macromolecule

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APA (6^th Edition):

Walker, T. A. (2003). Modification of Polymer Blend Phase Behavior with High-Pressure Carbon Dioxide. (Doctoral Dissertation). North Carolina State University. Retrieved from http://www.lib.ncsu.edu/resolver/1840.16/4080

Chicago Manual of Style (16^th Edition):

Walker, Teri Anne. “Modification of Polymer Blend Phase Behavior with High-Pressure Carbon Dioxide.” 2003. Doctoral Dissertation, North Carolina State University. Accessed March 08, 2021. http://www.lib.ncsu.edu/resolver/1840.16/4080.

MLA Handbook (7^th Edition):

Walker, Teri Anne. “Modification of Polymer Blend Phase Behavior with High-Pressure Carbon Dioxide.” 2003. Web. 08 Mar 2021.

Vancouver:

Walker TA. Modification of Polymer Blend Phase Behavior with High-Pressure Carbon Dioxide. [Internet] [Doctoral dissertation]. North Carolina State University; 2003. [cited 2021 Mar 08]. Available from: http://www.lib.ncsu.edu/resolver/1840.16/4080.

Council of Science Editors:

Walker TA. Modification of Polymer Blend Phase Behavior with High-Pressure Carbon Dioxide. [Doctoral Dissertation]. North Carolina State University; 2003. Available from: http://www.lib.ncsu.edu/resolver/1840.16/4080

University of Adelaide

7. Ngo, Huy Tien. Supramolecular chemistry of beta- and gamma- cyclodextrin dimers.

Degree: 2010, University of Adelaide

URL: http://hdl.handle.net/2440/65552

► Native and modified cyclodextrins (CDs) act as robust hosts for a variety of guest species in water, and therefore are at the centre of supramolecular… (more)

▼ Native and modified cyclodextrins (CDs) act as robust hosts for a variety of guest species in water, and therefore are at the centre of supramolecular chemistry. Covalently linked CD dimers provide many advantages over native CDs in complexation of guest species in terms of their stability, selectivity or flexibility. The studies underpinning this thesis are based on the β-cyclodextrin dimers, N,N’-bis((2AS,3AS)-3A-deoxy-β-cyclodextrin-3A-yl) succinamide, 33βCD₂suc, and N,N′-bis(6A-deoxy-B-cyclodextrin-6A-yl) succinamide, 66βCD₂suc, and the γ-cyclodextrin dimers, N,N′-bis((2AS,3AS)-3A-deoxy-γ-cyclodextrin-3A-yl) succinamide, 33γCD2suc, and N,N′’-bis(6A-deoxy-γ-cyclodextrin-6A-yl) succinamide, 66γCD2suc, in which the two βCD or γCD cavities are joined together through either the C₃A or C₆A carbons of altropyranose or glucopyranose units, respectively. Often in supramolecular systems, several competing equilibria exist, as exemplified by host–guest complexation and guest aggregation. The complexation of dimerising cationic pyronines B and Y, PB⁺ and PY⁺, by βCD and the βCD dimers, 33βC₂suc and 66βCD₂suc, has been studied by UV–vis, fluorescence and ¹H NMR spectroscopy. The complexation constants for the 1:1 host–guest complexes are reported as are the dimerisation constants for PB⁺ and PY⁺. The modes of complexation, dimerisation and fluorescence quenching are discussed in light of the structural differences and the 1D and 2D ¹H NMR spectroscopic data. The competitive equilibria between the dimerisation and host–guest complexation of hematoporphyrin, HP²⁻, by γCD and two newly synthesised γCD dimers, 33γCD₂suc and 66γCD₂suc, have been simultaneously quantified by UV–vis and fluorescence spectroscopy. The competing equilibrium constants, thermodynamic parameters and molecular modelling are reported and the nature of interaction between HP²⁻ and γCD and the γCD dimer hosts is discussed. The new 3% randomly substituted 1-naphthyl-sulfonamide poly(acrylate)s, PAA1NSen and PAA1NShn, have been prepared by 3% random substitution of either N-(2- aminoethyl)-1-naphthyl-sulfonamide or N-(6-aminohexyl)-1-naphthyl-sulfonamide onto the poly(acrylate) backbone. The complexation of the 1-naphthyl substituents by βCD and γCD and their succinamide–linked dimers, 33βCD₂suc, 66βCD₂suc, 33γCD₂suc and 66γCD₂suc, have been quantified by fluorescence spectroscopy. The competition between 1-naphthyl substituent aggregation and host–guest complexation by the linked CD dimers and the 1-naphthyl substituents in forming inter–polymer strand cross–links is examined in aqueous solution at the macroscopic level by rheology and at the molecular level by 2D ¹H NOESY NMR and fluorescence spectroscopy. Advisors/Committee Members: Lincoln, Stephen Frederick (advisor), School of Chemistry and Physics (school).

Subjects/Keywords: cyclodextrin; supramolecular chemistry; host-guest complex; polymer; macromolecule

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APA (6^th Edition):

Ngo, H. T. (2010). Supramolecular chemistry of beta- and gamma- cyclodextrin dimers. (Thesis). University of Adelaide. Retrieved from http://hdl.handle.net/2440/65552

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Ngo, Huy Tien. “Supramolecular chemistry of beta- and gamma- cyclodextrin dimers.” 2010. Thesis, University of Adelaide. Accessed March 08, 2021. http://hdl.handle.net/2440/65552.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Ngo, Huy Tien. “Supramolecular chemistry of beta- and gamma- cyclodextrin dimers.” 2010. Web. 08 Mar 2021.

Vancouver:

Ngo HT. Supramolecular chemistry of beta- and gamma- cyclodextrin dimers. [Internet] [Thesis]. University of Adelaide; 2010. [cited 2021 Mar 08]. Available from: http://hdl.handle.net/2440/65552.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Ngo HT. Supramolecular chemistry of beta- and gamma- cyclodextrin dimers. [Thesis]. University of Adelaide; 2010. Available from: http://hdl.handle.net/2440/65552

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

8. Wang, Jinghui. Characterization & Application of Immobilized Biomacromolecules using Microcantilever and QCM Sensors.

Degree: PhD, Engineering, 2014, Rice University

URL: http://hdl.handle.net/1911/77571

► The structure and function of immobilized biomacromolecules are likely to be altered because of the solid surface. The long-term objective of this thesis is to… (more)

▼ The structure and function of immobilized biomacromolecules are likely to be altered because of the solid surface. The long-term objective of this thesis is to develop surface-based biosensors for the characterization and application of biomacromolecules at the liquid-solid interface. In this study, two analytical surface-sensitive sensors are utilized: microcantilevers and quartz crystal microbalance with dissipation (QCM-D). Each offers unique information regarding the molecules of interest. In particular, the systems that are covered in this thesis include the detection of target analytes using specific recognition elements and the characterization of supported lipid membranes. This research has led to a better understanding of the effect of solid surfaces on protein structure and function, as well as the ability to engineer biomolecular surfaces with great control. There are two detection systems that were studied: a phage-derived peptide system for the detection of pathogenic bacteria Salmonella and an antibody displacement assay for the detection of an explosive, 2,4,6-trinitrotoluene (TNT). The microcantilever responds to changes in the surface free energy on the sensor surface by monitoring changes in its deflection. The physisorption or chemisorption of molecules to the cantilever surface induces a mismatch in the surface stress, causing the cantilever to bend. The multiplexed measurement is able to quickly determine the binding affinities of various phage-derived peptides, improving the screening efficiency of the peptides derived from phage display libraries for Salmonella detection. The microcantilever-based technique provides a novel biosensor to rapidly and accurately detect pathogens and holds potential to be further developed as a screening method to identify pathogen-specific recognition elements. QCM measures mass changes on the sensor surface by monitoring the frequency change of the crystal. The combination of a competition assay with QCM using an anti-TNT antibody is able to distinguish a TNT molecule among molecules of similar structure at low concentrations, leading a sensitive and selective assay. The reliability of this method was further investigated in more real environments simulated by fertilizer solution and seawater. Furthermore, this method could be also applied in gas phase detection of TNT, as well as the detection of other chemicals, such as environmental pollutants and illegal drugs. In both of these detection assays, a mathematical model was developed to quantify the binding of the target molecules with the molecules of interest. In the second half of the thesis, the microcantilever sensor is applied to characterize supported lipid bilayers (SLBs), an interesting biomacromolecular assembly that holds great importance as a model system for membranes. Through monitoring the cantilever deflection, the formation of the SLB, its temperature induced phase transitions, and its interactions with membrane-active molecules are investigated. With increasing temperature, the lipid acyl… Advisors/Committee Members: Biswal, Sibani Lisa (advisor), Segatori, Laura (committee member), Wong, Michael S. (committee member), McDevitt, John T. (committee member), Suh, Junghae (committee member).

Subjects/Keywords: Macromolecule; Biosensors; Chemical engineering

10 more images…

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APA (6^th Edition):

Wang, J. (2014). Characterization & Application of Immobilized Biomacromolecules using Microcantilever and QCM Sensors. (Doctoral Dissertation). Rice University. Retrieved from http://hdl.handle.net/1911/77571

Chicago Manual of Style (16^th Edition):

Wang, Jinghui. “Characterization & Application of Immobilized Biomacromolecules using Microcantilever and QCM Sensors.” 2014. Doctoral Dissertation, Rice University. Accessed March 08, 2021. http://hdl.handle.net/1911/77571.

MLA Handbook (7^th Edition):

Wang, Jinghui. “Characterization & Application of Immobilized Biomacromolecules using Microcantilever and QCM Sensors.” 2014. Web. 08 Mar 2021.

Vancouver:

Wang J. Characterization & Application of Immobilized Biomacromolecules using Microcantilever and QCM Sensors. [Internet] [Doctoral dissertation]. Rice University; 2014. [cited 2021 Mar 08]. Available from: http://hdl.handle.net/1911/77571.

Council of Science Editors:

Wang J. Characterization & Application of Immobilized Biomacromolecules using Microcantilever and QCM Sensors. [Doctoral Dissertation]. Rice University; 2014. Available from: http://hdl.handle.net/1911/77571

9. Mattson, Kaila Marie. Advancing Control in Polymer Chemistry.

Degree: 2016, University of California – eScholarship, University of California

URL: http://www.escholarship.org/uc/item/8xv1r35x

► Controlling molecular weight, architecture, and comonomer incorporation in polymers is of paramount importance for the preparation of functional materials. This dissertation will highlight the development… (more)

Subjects/Keywords: Chemistry; Polymer chemistry; Materials Science; Anionic Polymerization; Controlled Radical Polymerization; Macromolecule; Polymer; Surface; Synthesis

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APA (6^th Edition):

Mattson, K. M. (2016). Advancing Control in Polymer Chemistry. (Thesis). University of California – eScholarship, University of California. Retrieved from http://www.escholarship.org/uc/item/8xv1r35x

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Mattson, Kaila Marie. “Advancing Control in Polymer Chemistry.” 2016. Thesis, University of California – eScholarship, University of California. Accessed March 08, 2021. http://www.escholarship.org/uc/item/8xv1r35x.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Mattson, Kaila Marie. “Advancing Control in Polymer Chemistry.” 2016. Web. 08 Mar 2021.

Vancouver:

Mattson KM. Advancing Control in Polymer Chemistry. [Internet] [Thesis]. University of California – eScholarship, University of California; 2016. [cited 2021 Mar 08]. Available from: http://www.escholarship.org/uc/item/8xv1r35x.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Mattson KM. Advancing Control in Polymer Chemistry. [Thesis]. University of California – eScholarship, University of California; 2016. Available from: http://www.escholarship.org/uc/item/8xv1r35x

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

10. Xu, Zaikun. Developing A Bitwise Macromolecular Assembly Simulator.

Degree: MA, Molecular Biosciences, 2014, University of Kansas

URL: http://hdl.handle.net/1808/16809

► Macromolecular machines play fundamental roles in many cellular tasks, from intracellular transport to protein synthesis and degradation. The majority of these machines must adopt a… (more)

Subjects/Keywords: Bioinformatics; Assembly; Bitwise; Macromolecule; Simulator

…helpful to introduce a formal notation regarding our representation of the macromolecule itself… …a function of size of the ring in a stacked ring macromolecule. 15 Figures a 0 4 1 3…

15 more images…

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APA (6^th Edition):

Xu, Z. (2014). Developing A Bitwise Macromolecular Assembly Simulator. (Masters Thesis). University of Kansas. Retrieved from http://hdl.handle.net/1808/16809

Chicago Manual of Style (16^th Edition):

Xu, Zaikun. “Developing A Bitwise Macromolecular Assembly Simulator.” 2014. Masters Thesis, University of Kansas. Accessed March 08, 2021. http://hdl.handle.net/1808/16809.

MLA Handbook (7^th Edition):

Xu, Zaikun. “Developing A Bitwise Macromolecular Assembly Simulator.” 2014. Web. 08 Mar 2021.

Vancouver:

Xu Z. Developing A Bitwise Macromolecular Assembly Simulator. [Internet] [Masters thesis]. University of Kansas; 2014. [cited 2021 Mar 08]. Available from: http://hdl.handle.net/1808/16809.

Council of Science Editors:

Xu Z. Developing A Bitwise Macromolecular Assembly Simulator. [Masters Thesis]. University of Kansas; 2014. Available from: http://hdl.handle.net/1808/16809

University of New South Wales

11. Blunden, Bianca. Macromolecular Ruthenium Chemotherapeutics A Unique Approach to Metastatic Cancer Treatment.

Degree: Centre for Advanced Macromolecular Design, 2014, University of New South Wales

URL: http://handle.unsw.edu.au/1959.4/53550 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:12245/SOURCE02?view=true

► Novel macromolecular ruthenium chemotherapeutics were designed, synthesised and investigated in comparison to small drugs. Ruthenium possesses unique properties that have led to the development of… (more)

▼ Novel macromolecular ruthenium chemotherapeutics were designed, synthesised and investigated in comparison to small drugs. Ruthenium possesses unique properties that have led to the development of exceptionally promising anticancer and antimetastatic therapeutics. The ruthenium(III) and ruthenium(II) drugs, NAMI-A [trans-RuCl4(DMSO)Im]-ImH+ and RAPTA-C [RuCl2(p-cymene)(PTA)], respectively, are two such candidates. The amplified benefit that can be gained by incorporating drugs into macromolecules has not previously been investigated for ruthenium agents.Two novel approaches to the synthesis of two types of rationally designed polymers, both containing ruthenium, were developed based on the ruthenium anticancer drugs NAMI-A and RAPTA-C. Both approaches utilised a distinct ligand of each drug. The first approach relied on the polymerisation of 4-vinyl imidazole via RAFT polymerisation. This created a macromolecular ligand for ruthenium(III) to which a ruthenium precursor could be subsequently conjugated. The second approach used the inherent activity of the amide group on the PTA ligand of RAPTA-C to allow for conjugation to poly(2-iodoethyl methacrylate) via the substitution of the reactive halide. Two pathways were investigated to conjugate RAPTA-C to the polymer and both routes were tested using n-butyl iodide as a model compound. 1D and 2D NMR experiments were used to assess the conjugation and elucidate the superior pathway: a two-step reaction involving the conjugation of PTA via its reactive amine and subsequent complexation to form RAPTA-C.Nano-sized carriers were designed to increase the cell uptake of these macromolecular drugs micelles and nanotubes. Amphiphilic block copolymers incorporating NAMI-A or RAPTA-C were developed and self-assembled into micelles. RAPTA-C was also attached to cyclopeptide-polymer conjugates and self-assembled into nanotubes. A 1.5-times increase in cytotoxicity was found for NAMI-A micelles, and an outstanding 10-fold increase was found for both RAPTA-C micelles and nanotubes, when compared to the free drugs. An initial exploration into the antimetastatic activity revealed that the NAMI-A and RAPTA-C polymeric micelles significantly improved the inhibitory effects on both the migration and invasion of human breast cancer cells, indicating that it is highly probable that these nanoparticles will inhibit metastases in vivo. Thus, this work provides a substantial basis for the progression of these macromolecular chemotherapeutics into advanced biological studies. Advisors/Committee Members: Stenzel, Martina, Centre for Advanced Macromolecular Design, Faculty of Engineering, UNSW, Thomas, Donald, Mark Wainwright Analytical Centre, UNSW.

Subjects/Keywords: Chemotherapeutic; Macromolecule; Ruthenium; RAPTA-C; NAMI-A; Nanoparticle; Antimetastatic; Anticancer; Polymer; NMR; Nanotube

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APA (6^th Edition):

Blunden, B. (2014). Macromolecular Ruthenium Chemotherapeutics A Unique Approach to Metastatic Cancer Treatment. (Doctoral Dissertation). University of New South Wales. Retrieved from http://handle.unsw.edu.au/1959.4/53550 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:12245/SOURCE02?view=true

Chicago Manual of Style (16^th Edition):

Blunden, Bianca. “Macromolecular Ruthenium Chemotherapeutics A Unique Approach to Metastatic Cancer Treatment.” 2014. Doctoral Dissertation, University of New South Wales. Accessed March 08, 2021. http://handle.unsw.edu.au/1959.4/53550 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:12245/SOURCE02?view=true.

MLA Handbook (7^th Edition):

Blunden, Bianca. “Macromolecular Ruthenium Chemotherapeutics A Unique Approach to Metastatic Cancer Treatment.” 2014. Web. 08 Mar 2021.

Vancouver:

Blunden B. Macromolecular Ruthenium Chemotherapeutics A Unique Approach to Metastatic Cancer Treatment. [Internet] [Doctoral dissertation]. University of New South Wales; 2014. [cited 2021 Mar 08]. Available from: http://handle.unsw.edu.au/1959.4/53550 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:12245/SOURCE02?view=true.

Council of Science Editors:

Blunden B. Macromolecular Ruthenium Chemotherapeutics A Unique Approach to Metastatic Cancer Treatment. [Doctoral Dissertation]. University of New South Wales; 2014. Available from: http://handle.unsw.edu.au/1959.4/53550 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:12245/SOURCE02?view=true

12. Duan, Gang. Harnessing Interfacial Phenomena Involving Macromolecules For Emulsion Processing.

Degree: 2018, University of Pennsylvania

URL: https://repository.upenn.edu/edissertations/3109

► An emulsion is a mixture of two immiscible solutions, one dispersed in the other. Intrinsically, most emulsions are thermodynamically unstable and thus active agents called… (more)

▼ An emulsion is a mixture of two immiscible solutions, one dispersed in the other. Intrinsically, most emulsions are thermodynamically unstable and thus active agents called surfactant are added to the mixture to stabilize the interface. The surfactant lowers the interfacial tension and provides steric and/or electrostatic repulsion at the fluid interfaces to enhance the stability of emulsions. Macromolecules, either intrinsically surface active or not, have attracted lots of attention for emulsion processing. On one hand, advances in polymeric synthesis technique present various polymeric surfactants waiting to be exploited. On the other hand, macromolecules present the platform for versatile modification that can result in assemblies with special properties. Various natural materials are also macromolecules, waiting to be exploited as replacements for synthetic surfactants of petrochemical origins. In this thesis, ion pairing and microfluidic techniques are used to expand the macromolecules’ application and to investigate the composition effect of polymeric surfactants in emulsion processing. Polyelectrolyte is extracted into an organic phase via ion pairing with an oppositely charged surfactant. The formed ion pair retain the polyelectrolyte’s capability to form complexes. It complexes with oppositely charged polyelectrolyte and is exploited for one-step polyelectrolyte microcapsules generation. Meanwhile, the composition effect of a set of polymeric surfactants, Pluronics, on flow-induced phase inversion emulsification (FIPIE) is studied. Through microfluidic technology, emulsion phase inversion process at the single droplet level is monitored. We find strong correlation between the molecular weight (MW) and the lengths of individual blocks of the Pluronics and the tendency of droplets to undergo (FIPIE). In Chapter 4, dynamic ion pairing between polyelectrolyte and surfactant is used to induce phase inversion emulsification (PIE). The ion pair formation is controlled as a function of the solution pH and surfactant concentration. Both oil-in-water (O/W) and water-in-oil (W/O) emulsions are formed and PIE from W/O to O/W emulsion is demonstrated. In summary, macromolecules possess rich behaviors at the emulsion interfaces. The macromolecule and surfactant association, such as ion pairing, form assemblies with distinct properties, expanding common materials’ application for versatile emulsion processing.

Subjects/Keywords: Emulsion; Macromolecule; Chemical Engineering; Engineering

…macromolecule and surfactant association, such as ion pairing, form assemblies with distinct… …attached to a macromolecule, the resulting macromolecular entity can have rich emulsification…

10 more images…

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APA (6^th Edition):

Duan, G. (2018). Harnessing Interfacial Phenomena Involving Macromolecules For Emulsion Processing. (Thesis). University of Pennsylvania. Retrieved from https://repository.upenn.edu/edissertations/3109

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Duan, Gang. “Harnessing Interfacial Phenomena Involving Macromolecules For Emulsion Processing.” 2018. Thesis, University of Pennsylvania. Accessed March 08, 2021. https://repository.upenn.edu/edissertations/3109.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Duan, Gang. “Harnessing Interfacial Phenomena Involving Macromolecules For Emulsion Processing.” 2018. Web. 08 Mar 2021.

Vancouver:

Duan G. Harnessing Interfacial Phenomena Involving Macromolecules For Emulsion Processing. [Internet] [Thesis]. University of Pennsylvania; 2018. [cited 2021 Mar 08]. Available from: https://repository.upenn.edu/edissertations/3109.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Duan G. Harnessing Interfacial Phenomena Involving Macromolecules For Emulsion Processing. [Thesis]. University of Pennsylvania; 2018. Available from: https://repository.upenn.edu/edissertations/3109

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

King Abdullah University of Science and Technology

13. Villalobos, Luis Francisco. Complexation-Induced Phase Separation: Preparation of Metal-Rich Polymeric Membranes.

Degree: Physical Science and Engineering (PSE) Division, 2017, King Abdullah University of Science and Technology

URL: http://hdl.handle.net/10754/625433

► The majority of state-of-the-art polymeric membranes for industrial or medical applications are fabricated by phase inversion. Complexation induced phase separation (CIPS)—a surprising variation of this… (more)

▼ The majority of state-of-the-art polymeric membranes for industrial or medical applications are fabricated by phase inversion. Complexation induced phase separation (CIPS)—a surprising variation of this well-known process—allows direct fabrication of hybrid membranes in existing facilities. In the CIPS process, a first step forms the thin metal-rich selective layer of the membrane, and a succeeding step the porous support. Precipitation of the selective layer takes place in the same solvent used to dissolve the polymer and is induced by a small concentration of metal ions. These ions form metal-coordination-based crosslinks leading to the formation of a solid skin floating on top of the liquid polymer film. A subsequent precipitation in a nonsolvent bath leads to the formation of the porous support structure. Forming the dense layer and porous support by different mechanisms while maintaining the simplicity of a phase inversion process, results in unprecedented control over the final structure of the membrane. The thickness and morphology of the dense layer as well as the porosity of the support can be controlled over a wide range by manipulating simple process parameters. CIPS facilitates control over (i) the thickness of the dense layer throughout several orders of magnitude—from less than 15 nm to more than 6 μm, (ii) the type and amount of metal ions loaded in the dense layer, (iii) the morphology of the membrane surface, and (iv) the porosity and structure of the support. The nature of the CIPS process facilitates a precise loading of a high concentration of metal ions that are located in only the top layer of the membrane. Moreover, these metal ions can be converted—during the membrane fabrication process—to nanoparticles or crystals. This simple method opens up fascinating possibilities for the fabrication of metal-rich polymeric membranes with a new set of properties. This dissertation describes the process in depth and explores promising applications: (i) catalytic membranes containing palladium nanoparticles (PdNPs), (ii) antibiofouling tight-UF membranes containing silver chloride (AgCl) crystals, and (iii) palladiumrich PBI hollow fibers for H2 recovery. Advisors/Committee Members: Peinemann, Klaus-Viktor (advisor), Pinnau, Ingo (committee member), Eddaoudi, Mohamed (committee member), Freeman, Benny Dean (committee member).

Subjects/Keywords: asymmetric membrane; macromolecule-metal complex; Phase Inversion; Hydrogen recovery; Anti-biofouling; Catalytic membrane

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APA (6^th Edition):

Villalobos, L. F. (2017). Complexation-Induced Phase Separation: Preparation of Metal-Rich Polymeric Membranes. (Thesis). King Abdullah University of Science and Technology. Retrieved from http://hdl.handle.net/10754/625433

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Villalobos, Luis Francisco. “Complexation-Induced Phase Separation: Preparation of Metal-Rich Polymeric Membranes.” 2017. Thesis, King Abdullah University of Science and Technology. Accessed March 08, 2021. http://hdl.handle.net/10754/625433.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Villalobos, Luis Francisco. “Complexation-Induced Phase Separation: Preparation of Metal-Rich Polymeric Membranes.” 2017. Web. 08 Mar 2021.

Vancouver:

Villalobos LF. Complexation-Induced Phase Separation: Preparation of Metal-Rich Polymeric Membranes. [Internet] [Thesis]. King Abdullah University of Science and Technology; 2017. [cited 2021 Mar 08]. Available from: http://hdl.handle.net/10754/625433.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Villalobos LF. Complexation-Induced Phase Separation: Preparation of Metal-Rich Polymeric Membranes. [Thesis]. King Abdullah University of Science and Technology; 2017. Available from: http://hdl.handle.net/10754/625433

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Michigan

14. Kojima, Taisuke. Development Of Microcompartmentalization Using Macromolecules And Liquid-Liquid Interfaces.

Degree: PhD, Macromolecular Science and Engineering, 2016, University of Michigan

URL: http://hdl.handle.net/2027.42/120885

► Compartmentalization combined with regulated exchange and release of biomaterials is the key biological function. At the subcellular level, organelles sequester enzymes and substrates for storage… (more)

▼ Compartmentalization combined with regulated exchange and release of biomaterials is the key biological function. At the subcellular level, organelles sequester enzymes and substrates for storage while processing and releasing on demand. At the organism level, appropriate cellular compartmentalization gives rise to tissue organization and higher order function. Man-made bioreaction compartmentalization typically relies on micro-reactors constructed with glass, silicon, hard plastic, or amiphiphilic molecular walls. Reactors with such physical barriers, in return for excellent compartmentalization, lack amenability to molecular and cellular release and exchange as seen in the body. This thesis describes the engineering of multi-compartment bioreactors that utilize stable reagent partitioning within immiscible aqueous solutions. The all aqueous compartmentalization scheme, when combined with a micropatterned surface that pins the liquid-liquid interfaces, enable versatile direct printing of arbitrary multi-compartment bioreactor networks. Additionally, the lack of physical barriers at the liquid-liquid interface between the different aqueous compartments allows use of phase-altering chemicals to trigger rapid and selective mixing of materials between compartments in ways not possible with conventional miroreactors. Specific examples demonstrated include a compartmentalized cascade reaction that utilizes glucose and oxygen as nutrients to catalzye the production of different colored dyes within microcompartments and the localization-enhanced degradation of the microcompartments with a polysaccharide-degrading enzyme. In a separate strategy, a shrinking microreactor platform was created using oil dehydration. These shrinking bioreactors were utilized for micro-scale ATPS phase diagram determination and also adopted for micro-scale self-assembly of CdTe nanoparticles. Finally, surface-templated hydrogel micropatterning was used to compartmentalize cancer cells as well as limit diffusion of chemoattractants. This platform revealed the importance of extracellular matrix-mediated capture and localization of chemoattractants in triggering cancer cell migration that lead to a breakdown of cellular compartmentalization, tissue dis-organization and cancer metastasis. In addition to the specific demonstrations and biological insights obtained, the described macromolecular phase-separation microreactor platforms are versatile in configuration possibilities, particularly when combined with microfabrication technologies, and amenable to further explore materials science and biomedical engineering applications. Advisors/Committee Members: Takayama, Shuichi (committee member), Kotov, Nicholas (committee member), Lahann, Joerg (committee member), Robertson, Richard E (committee member), Tuteja, Anish (committee member).

Subjects/Keywords: Compartmentalization; Microreactor; Macromolecule; Liquid-liquid Interface; Biomedical Engineering; Engineering (General); Materials Science and Engineering; Chemistry; Science (General); Engineering; Science

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APA (6^th Edition):

Kojima, T. (2016). Development Of Microcompartmentalization Using Macromolecules And Liquid-Liquid Interfaces. (Doctoral Dissertation). University of Michigan. Retrieved from http://hdl.handle.net/2027.42/120885

Chicago Manual of Style (16^th Edition):

Kojima, Taisuke. “Development Of Microcompartmentalization Using Macromolecules And Liquid-Liquid Interfaces.” 2016. Doctoral Dissertation, University of Michigan. Accessed March 08, 2021. http://hdl.handle.net/2027.42/120885.

MLA Handbook (7^th Edition):

Kojima, Taisuke. “Development Of Microcompartmentalization Using Macromolecules And Liquid-Liquid Interfaces.” 2016. Web. 08 Mar 2021.

Vancouver:

Kojima T. Development Of Microcompartmentalization Using Macromolecules And Liquid-Liquid Interfaces. [Internet] [Doctoral dissertation]. University of Michigan; 2016. [cited 2021 Mar 08]. Available from: http://hdl.handle.net/2027.42/120885.

Council of Science Editors:

Kojima T. Development Of Microcompartmentalization Using Macromolecules And Liquid-Liquid Interfaces. [Doctoral Dissertation]. University of Michigan; 2016. Available from: http://hdl.handle.net/2027.42/120885

Vanderbilt University

15. Allison, Brittany Ann. Computational Design of Protein-Ligand Interfaces Using RosettaLigand.

Degree: PhD, Chemistry, 2016, Vanderbilt University

URL: http://hdl.handle.net/1803/11616

► Computational design of protein-ligand interfaces expands understanding of the basic forces involved in molecular recognition, and also contributes to the development of protein therapeutics. My… (more)

▼ Computational design of protein-ligand interfaces expands understanding of the basic forces involved in molecular recognition, and also contributes to the development of protein therapeutics. My dissertation research contributes to this body of knowledge through a series of Specific Aims. Specific Aim 1 involves screening a diverse set of small molecules for intrinsic binding affinity to my protein, HisF. 28 binding ligands were identified by using nuclear magnetic resonance (NMR) techniques by tracking chemical shift peaks. This also allows us to calculation dissociation constants, which ranged between 340 – 1110 µM. These binding ligands were then computationally docked into HisF using RosettaLigand of the Rosetta modeling suite. Computational results were compared to the experimental data to identify strengths/weaknesses of the program. These results are the focus of Chapter 3, “Experimental and Computational Identification of Naïve Binders to a TIM-Barrel Protein Scaffold” (first author), to be submitted soon. Specific Aim 2 involved optimizing RosettaLigand to design proteins that bind small molecules. The software was tested for accuracy and efficiency using a set of protein-ligand crystal structures, and these results are the focus of my 2014 published manuscript and Chapter 2, “Computational Design of Protein-Small Molecule Interfaces” (first author). A detailed description of how to utilize RosettaLigand is the focus of Chapter 4, “Rosetta and Design of Ligand Binding Sites” (secondary author), manuscript accepted. Specific Aim 3 combines the first two aims, to redesign the protein interface to bind the small molecules more tightly than the wild type protein. We have used RosettaLigand to redesign HisF to bind one VU0068924 more tightly, with binding affinity improving from 442 µM to 23 µM. This is the focus of Appendix C “Designed C9S_HisF Binds VU0068924 More Tightly”, and will be the focus of a future manuscript. For each project, the protocols, scripts, command-lines, experiments not described in the manuscript are included in the appendix. The models, code, scripts, and figures are included in the thesis directory that accompanies the thesis. Advisors/Committee Members: Brian O. Bachmann, Ph.D. (committee member), Michael P. Stone, PhD. (committee member), John A. Capra, Ph.D. (committee member), Jens Meiler, Ph.D. (Committee Chair).

Subjects/Keywords: protein engineering; protein ligand binding; RosettaLigand; Rosetta; protein small molecule interactions; interface design; computational design; ligand macromolecule recognition; NMR; binding affinity

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APA (6^th Edition):

Allison, B. A. (2016). Computational Design of Protein-Ligand Interfaces Using RosettaLigand. (Doctoral Dissertation). Vanderbilt University. Retrieved from http://hdl.handle.net/1803/11616

Chicago Manual of Style (16^th Edition):

Allison, Brittany Ann. “Computational Design of Protein-Ligand Interfaces Using RosettaLigand.” 2016. Doctoral Dissertation, Vanderbilt University. Accessed March 08, 2021. http://hdl.handle.net/1803/11616.

MLA Handbook (7^th Edition):

Allison, Brittany Ann. “Computational Design of Protein-Ligand Interfaces Using RosettaLigand.” 2016. Web. 08 Mar 2021.

Vancouver:

Allison BA. Computational Design of Protein-Ligand Interfaces Using RosettaLigand. [Internet] [Doctoral dissertation]. Vanderbilt University; 2016. [cited 2021 Mar 08]. Available from: http://hdl.handle.net/1803/11616.

Council of Science Editors:

Allison BA. Computational Design of Protein-Ligand Interfaces Using RosettaLigand. [Doctoral Dissertation]. Vanderbilt University; 2016. Available from: http://hdl.handle.net/1803/11616

Texas A&M University

16. McLean, Megan Elizabeth. Synthesis and characterization of covalently-linked dendrimer bioconjugates and the non-covalent self-assembly of streptavidin-based megamers.

Degree: PhD, Chemistry, 2005, Texas A&M University

URL: http://hdl.handle.net/1969.1/1319

► This work details the attachment of dendrimers to proteins, peptides and single stranded DNA (ssDNA). Dendrimers based on melamine satisfy many of the synthetic demands… (more)

▼ This work details the attachment of dendrimers to proteins, peptides and single stranded DNA (ssDNA). Dendrimers based on melamine satisfy many of the synthetic demands in the field of bioconjugate chemistry including: monodispersity, synthetic flexibility and scalability. The solution-phase syntheses of both ssDNA-dendrimer and peptide-dendrimer bioconjugates is described, and thorough characterization by matrix-assisted laser desorption ionization/ time-of-flight (MALDI-TOF) mass spectrometry, UV-vis spectroscopy, fluorescence spectroscopy, and polyacrylamide gel electrophoresis is discussed. Non-covalent DNA-dendrimer complexes have been shown to facilitate antisense gene delivery, but are vulnerable to dissociation and subsequent enzymatic degradation within the cell. In an effort to prepare biocompatible antisense agents capable of effectively shielding ssDNA from intracellular nuclease digestion, disulfide-linked ssDNA-dendrimers were prepared and rigorously characterized to rule out the possibility of an electrostatic-based interaction. Hybridization assays were performed to determine if the covalently-attached dendrimer affected the ability of the attached ssDNA strand to anneal with a complementary sequence to form double-stranded DNA (dsDNA)-dendrimers. Results indicate that ssDNA-dendrimer conjugates readily anneal to complementary ssDNA strands either in solution or attached to gold surfaces. Nuclease digestions of conjugates in solution suggested that enzymatic manipulation of dsDNA-dendrimers is possible, offering promise for DNA-based computation and other fields of DNA-nanotechnology. Much larger bioconjugates consisting of dendrimers, proteins and peptides were prepared with the goal of obtaining molecular weights sufficient for enhanced permeability and retention (EPR) in tumors. While the dendrimer provides the advantages of a purely synthetic route for drug delivery, the protein portion of the bioconjugate provides a monodisperse, macromolecular scaffold for the non-covalent self-assembly of the dendrimers. The strategy presented herein is based on the strong interaction between biotin and the 60 kD tetrameric protein streptavidin. Each monomer of streptavidin is capable of binding 1 biotin molecule, thus when biotin functionalized peptide-dendrimers are added to streptavidin they bind to form a cluster of dendrimers, or a megamer. The biotinylated peptides that link the dendrimers to the streptavidin core provide a way to actively target specific cell types for drug delivery. Megamer formation through the addition of tetrameric streptavidin was successful as indicated by MALDI-TOF, UV-vis titration and gel electrophoresis assays. Advisors/Committee Members: Simanek, Eric (advisor), Pepper, Alan (committee member), Sulikowski, Gary (committee member), Crooks, Richard (committee member).

Subjects/Keywords: bioconjugate; dendrimer; nanotechnology; drug delivery; macromolecule; gene therapy

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APA (6^th Edition):

McLean, M. E. (2005). Synthesis and characterization of covalently-linked dendrimer bioconjugates and the non-covalent self-assembly of streptavidin-based megamers. (Doctoral Dissertation). Texas A&M University. Retrieved from http://hdl.handle.net/1969.1/1319

Chicago Manual of Style (16^th Edition):

McLean, Megan Elizabeth. “Synthesis and characterization of covalently-linked dendrimer bioconjugates and the non-covalent self-assembly of streptavidin-based megamers.” 2005. Doctoral Dissertation, Texas A&M University. Accessed March 08, 2021. http://hdl.handle.net/1969.1/1319.

MLA Handbook (7^th Edition):

McLean, Megan Elizabeth. “Synthesis and characterization of covalently-linked dendrimer bioconjugates and the non-covalent self-assembly of streptavidin-based megamers.” 2005. Web. 08 Mar 2021.

Vancouver:

McLean ME. Synthesis and characterization of covalently-linked dendrimer bioconjugates and the non-covalent self-assembly of streptavidin-based megamers. [Internet] [Doctoral dissertation]. Texas A&M University; 2005. [cited 2021 Mar 08]. Available from: http://hdl.handle.net/1969.1/1319.

Council of Science Editors:

McLean ME. Synthesis and characterization of covalently-linked dendrimer bioconjugates and the non-covalent self-assembly of streptavidin-based megamers. [Doctoral Dissertation]. Texas A&M University; 2005. Available from: http://hdl.handle.net/1969.1/1319

Freie Universität Berlin

17. Najjar, Iris. Polysulfated dendrons as drug delivery systems for enzymes in cancer therapy.

Degree: 2018, Freie Universität Berlin

URL: https://refubium.fu-berlin.de/handle/fub188/12343

► Introduction: Conventional chemotherapeutic drugs are mostly associated with high systemic cytotoxicity because of their low selectivity. Selectivity can be increased by the use of targeted… (more)

▼ Introduction: Conventional chemotherapeutic drugs are mostly associated with high systemic cytotoxicity because of their low selectivity. Selectivity can be increased by the use of targeted drug delivery systems which lead to lower side effects and better therapeutic outcomes. Dendritic polymers have shown to be promising targeted drug delivery systems (TDDS) in cancer. In this thesis, the MacroDel (Macromolecular Delivery), a synthetic polysulfated Dendron made of glycerol monomers, is evaluated regarding its ability to act as a TDDS for enzymes. Several enzymes have high cytotoxic potential. However, the inability to transport them to their cytoplasmatic target has been the major reason why enzymes have rarely been used in chemotherapies. By using the example of RNase, DNase and Asparaginase, this thesis analyses the potential of MacroDels as targeted drug delivery systems for enzymes in cancer treatment. Methods: The conjugation of the enzymes to the MacroDel was controlled through native gelelectrophoresis and the enzyme activity after conjugation through photometry. The MacroDel and the MacroDel-enzyme conjugates were conjugated to ICC-dyes. The in vitro uptake and distribution were then analysed on all cancer cell lines using flow cytometry and fluorescence microscopy. The in vivo analysis was performed on Nude-Fox1nu mices transplanted with the human coloncarcinoma HT29 and a gastropancreatic tumor. Cytotoxicity of the MacroDel and its enzyme-conjugates were examined in vitro using MTT-assays. The uptake of the MacroDel and its conjugates were analysed by inhibiting OATP1B1 with Rifamycin. Results: It could be shown that the conjugation of enzymes to the MacroDel is possible without losing enzymatic activity. Furthermore, it could be demonstrated that all cancer cell lines take up the MacroDel and the MacroDel-enzyme conjugates in vitro and accumulate in vivo in cancer tissues. Their uptake is downregulated by the Inhibition of OATP-Transporters. Additionally the MacroDel and the MacroDel-enzyme conjugates show a cytotoxic effect on several cancer cell lines in vitro. Conclusion: For the first time, it could be shown that MacroDels are able to target enzymes to cancer tissues. Furthermore, it could be demonstrated that MacroDels and the MacroDel-enzyme conjugates are directly uptaken into the cytoplasm of cancer cells by transporters. Consequently, MacroDels represent a promising TDDS for enzymes in cancer that should be further investigated. Also the MacroDel would enable the targeting of a multitude of new cytoplasmatic structures that were inaccessible before. Advisors/Committee Members: w (gender), N.N. (firstReferee), N.N. (furtherReferee).

Subjects/Keywords: polysulfated macromolecule; macrodel; dendron; dendritic polyglycerolsulfate; targeted drug delivery system; 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Najjar, I. (2018). Polysulfated dendrons as drug delivery systems for enzymes in cancer therapy. (Thesis). Freie Universität Berlin. Retrieved from https://refubium.fu-berlin.de/handle/fub188/12343

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Najjar, Iris. “Polysulfated dendrons as drug delivery systems for enzymes in cancer therapy.” 2018. Thesis, Freie Universität Berlin. Accessed March 08, 2021. https://refubium.fu-berlin.de/handle/fub188/12343.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Najjar, Iris. “Polysulfated dendrons as drug delivery systems for enzymes in cancer therapy.” 2018. Web. 08 Mar 2021.

Vancouver:

Najjar I. Polysulfated dendrons as drug delivery systems for enzymes in cancer therapy. [Internet] [Thesis]. Freie Universität Berlin; 2018. [cited 2021 Mar 08]. Available from: https://refubium.fu-berlin.de/handle/fub188/12343.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Najjar I. Polysulfated dendrons as drug delivery systems for enzymes in cancer therapy. [Thesis]. Freie Universität Berlin; 2018. Available from: https://refubium.fu-berlin.de/handle/fub188/12343

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

18. RUAN GANG. Controlled release of anticancer drugs, proteins and liposomes by polymeric microspheres.

Degree: 2004, National University of Singapore

URL: http://scholarbank.nus.edu.sg/handle/10635/13973

Subjects/Keywords: Taxol; Drug delivery; Microencapsulation; Biodegradable Polymer; Supramolecular Structure; Macromolecule.

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

GANG, R. (2004). Controlled release of anticancer drugs, proteins and liposomes by polymeric microspheres. (Thesis). National University of Singapore. Retrieved from http://scholarbank.nus.edu.sg/handle/10635/13973

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

GANG, RUAN. “Controlled release of anticancer drugs, proteins and liposomes by polymeric microspheres.” 2004. Thesis, National University of Singapore. Accessed March 08, 2021. http://scholarbank.nus.edu.sg/handle/10635/13973.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

GANG, RUAN. “Controlled release of anticancer drugs, proteins and liposomes by polymeric microspheres.” 2004. Web. 08 Mar 2021.

Vancouver:

GANG R. Controlled release of anticancer drugs, proteins and liposomes by polymeric microspheres. [Internet] [Thesis]. National University of Singapore; 2004. [cited 2021 Mar 08]. Available from: http://scholarbank.nus.edu.sg/handle/10635/13973.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

GANG R. Controlled release of anticancer drugs, proteins and liposomes by polymeric microspheres. [Thesis]. National University of Singapore; 2004. Available from: http://scholarbank.nus.edu.sg/handle/10635/13973

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Virginia Tech

19. Chakraborty, Promita. A Computational Framework for Interacting with Physical Molecular Models of the Polypeptide Chain.

Degree: PhD, Computer Science and Applications, 2014, Virginia Tech

URL: http://hdl.handle.net/10919/47932

► Although nonflexible, scaled molecular models like Pauling-Corey's and its descendants have made significant contributions in structural biology research and pedagogy, recent technical advances in 3D… (more)

▼ Although nonflexible, scaled molecular models like Pauling-Corey's and its descendants have made significant contributions in structural biology research and pedagogy, recent technical advances in 3D printing and electronics make it possible to go one step further in designing physical models of biomacromolecules: to make them conformationally dynamic. We report the design, construction, and validation of a flexible, scaled, physical model of the polypeptide chain, which accurately reproduces the bond rotational degrees-of-freedom in the peptide backbone. The coarse-grained backbone model consists of repeating amide and alpha-carbon units, connected by mechanical bonds (corresponding to phi and psi angles) that include realistic barriers to rotation that closely approximate those found at the molecular scale. Longer-range hydrogen-bonding interactions are also incorporated, allowing the chain to easily fold into stable secondary structures. This physical model can serve as the basis for linking tangible bio-macromolecular models directly to the vast array of existing computational tools to provide an enhanced and interactive human-computer interface. We have explored the boundaries of this direction at the interface of computational tools and physical models of biological macromolecules at the nano-scale. Using a CAD-biocomputational framework, we have provided a methodology to design and build physical protein models focusing on shape and dynamics. We have also developed a workflow and an interface implemented for such bio-modeling tools. This physical-digital interface paradigm, at the intersection of native state proteins (P), computational models (C) and physical models (P), provides new opportunities for building an interactive computational modeling tool for protein folding and drug design. Furthermore, this model is easily constructed with readily obtainable parts and promises to be a tremendous educational aid to the intuitive understanding of chain folding as the basis for macromolecular structure. Advisors/Committee Members: Zuckermann, Ronald N. (committeechair), Onufriev, Alexey (committeechair), Ramakrishnan, Naren (committee member), Zhang, Liqing (committee member), Derisi, Joseph L. (committee member).

Subjects/Keywords: Physical models; polypeptides; Ramachandran plot; 3D-printing; molecular model; protein folding; structural biology; biochemistry education; physical-digital interface; macromolecule; Peppytide

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Chakraborty, P. (2014). A Computational Framework for Interacting with Physical Molecular Models of the Polypeptide Chain. (Doctoral Dissertation). Virginia Tech. Retrieved from http://hdl.handle.net/10919/47932

Chicago Manual of Style (16^th Edition):

Chakraborty, Promita. “A Computational Framework for Interacting with Physical Molecular Models of the Polypeptide Chain.” 2014. Doctoral Dissertation, Virginia Tech. Accessed March 08, 2021. http://hdl.handle.net/10919/47932.

MLA Handbook (7^th Edition):

Chakraborty, Promita. “A Computational Framework for Interacting with Physical Molecular Models of the Polypeptide Chain.” 2014. Web. 08 Mar 2021.

Vancouver:

Chakraborty P. A Computational Framework for Interacting with Physical Molecular Models of the Polypeptide Chain. [Internet] [Doctoral dissertation]. Virginia Tech; 2014. [cited 2021 Mar 08]. Available from: http://hdl.handle.net/10919/47932.

Council of Science Editors:

Chakraborty P. A Computational Framework for Interacting with Physical Molecular Models of the Polypeptide Chain. [Doctoral Dissertation]. Virginia Tech; 2014. Available from: http://hdl.handle.net/10919/47932

University of Arizona

20. Lauters, Michael E. Organic Opto-Electronic Devices for Data Storage and Solid-State Lighting .

Degree: 2006, University of Arizona

URL: http://hdl.handle.net/10150/193770

► Metal/organic/indium tin oxide (ITO) structures, including OLEDs, are demonstrated to contain multiple nonvolatile conductance states that can be programmed by the application of an external… (more)

▼ Metal/organic/indium tin oxide (ITO) structures, including OLEDs, are demonstrated to contain multiple nonvolatile conductance states that can be programmed by the application of an external bias above a certain threshold voltage (Vth). These conductance states are stable and in turn can be probed by the use of a bias lower in value than Vth. The unbiased retention time of states is greater than several weeks, and more than 48,000 write-read-rewrite-read cycles have been performed with minimal degradation. It is found that the programming of a continuum of conductance states is possible, and techniques to do so are outlined. The electrical conductivity of the highest and lowest states can differ by six orders of magnitude. Switching speeds below 50 ns are shown, resulting in an energy requirement of about 100 pJ to switch from one conductance state to another. The memory phenomenon is shown to be influenced by the active layer thickness and anode/surface roughness while temperature dependence is limited. The electrical characteristics of these devices are consistent with metal diffusion or filament phenomena found in metal-insulator-metal structures, suggesting a possible mechanism by which the states are stored.Electroluminescent devices employing several new organic-inorganic lumophore-functionalized macromolecules are presented. In this study, macromolecules incorporating several lumophores covalently bonded to the vertices of a cubical core structure based on Polyhedral Oligomeric Silsesquioxane (POSS) in multiple configurations are implemented as light-emitting centers. The hole-transporting polymer poly(N-vinylcarbazole) (PVK) and electron-transporting additive 2-(4-biphenylyl)-5-(4-tert-butylphenyl)1,3,4-oxadiazole (PBD) are used as a two-part host to enhance the carrier transport in these simple solution-processed single-layer devices. A study of energy transfer in several systems is carried out to understand the requirements needed to create white-light emission from a single macromolecule. A single macromolecule incorporating twenty-one blue and one yellow lumophore is shown to exhibit field-independent stable white-light electroluminescence with Commission Internationale de l'Eclairage (CIE) coordinates of (0.31, 0.37). An external quantum efficiency of 0.55 percent and a maximum brightness of 1600 cd/m2 are attained with simple solution-processed single-layer devices. High solubility and ease of purification give these macromolecule white-light emitters advantages over their small molecule and polymeric type counterparts. Advisors/Committee Members: Sarid, Dror (advisor), Jabbour, Ghassan (committeemember), Milster, Thomas (committeemember).

Subjects/Keywords: Organic Light Emitting Diode; Memory; Conductance States; MIM; Macromolecule

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Lauters, M. E. (2006). Organic Opto-Electronic Devices for Data Storage and Solid-State Lighting . (Doctoral Dissertation). University of Arizona. Retrieved from http://hdl.handle.net/10150/193770

Chicago Manual of Style (16^th Edition):

Lauters, Michael E. “Organic Opto-Electronic Devices for Data Storage and Solid-State Lighting .” 2006. Doctoral Dissertation, University of Arizona. Accessed March 08, 2021. http://hdl.handle.net/10150/193770.

MLA Handbook (7^th Edition):

Lauters, Michael E. “Organic Opto-Electronic Devices for Data Storage and Solid-State Lighting .” 2006. Web. 08 Mar 2021.

Vancouver:

Lauters ME. Organic Opto-Electronic Devices for Data Storage and Solid-State Lighting . [Internet] [Doctoral dissertation]. University of Arizona; 2006. [cited 2021 Mar 08]. Available from: http://hdl.handle.net/10150/193770.

Council of Science Editors:

Lauters ME. Organic Opto-Electronic Devices for Data Storage and Solid-State Lighting . [Doctoral Dissertation]. University of Arizona; 2006. Available from: http://hdl.handle.net/10150/193770

Virginia Tech

21. Gordon, John Carroll. A new computationally facile approximation of electrostatic potential suitable for macromolecules.

Degree: MS, Computer Science, 2007, Virginia Tech

URL: http://hdl.handle.net/10919/31216

► The electrostatic properties of a molecule are often essential in determining its behavior; as such, the ability to approximate these electrostatic potentials computationally is often… (more)

Subjects/Keywords: Virus; Macromolecule; GEM; APLB; Poisson-Boltzmann; Electrostatic potential

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Gordon, J. C. (2007). A new computationally facile approximation of electrostatic potential suitable for macromolecules. (Masters Thesis). Virginia Tech. Retrieved from http://hdl.handle.net/10919/31216

Chicago Manual of Style (16^th Edition):

Gordon, John Carroll. “A new computationally facile approximation of electrostatic potential suitable for macromolecules.” 2007. Masters Thesis, Virginia Tech. Accessed March 08, 2021. http://hdl.handle.net/10919/31216.

MLA Handbook (7^th Edition):

Gordon, John Carroll. “A new computationally facile approximation of electrostatic potential suitable for macromolecules.” 2007. Web. 08 Mar 2021.

Vancouver:

Gordon JC. A new computationally facile approximation of electrostatic potential suitable for macromolecules. [Internet] [Masters thesis]. Virginia Tech; 2007. [cited 2021 Mar 08]. Available from: http://hdl.handle.net/10919/31216.

Council of Science Editors:

Gordon JC. A new computationally facile approximation of electrostatic potential suitable for macromolecules. [Masters Thesis]. Virginia Tech; 2007. Available from: http://hdl.handle.net/10919/31216

McMaster University

22. Li, Su. Living Polystyrene Anions Terminated with Difulvene.

Degree: MSc, 1991, McMaster University

URL: http://hdl.handle.net/11375/19382

►

This project proposal is focused on the development of a novel class of Viscosity Index improvers. A bench-top method for living anionic polymerization has… (more)

Subjects/Keywords: living; polystyrene; anions; difulvene; polymerization; macromolecule; functional groups; nuclear; magnetic

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APA (6^th Edition):

Li, S. (1991). Living Polystyrene Anions Terminated with Difulvene. (Masters Thesis). McMaster University. Retrieved from http://hdl.handle.net/11375/19382

Chicago Manual of Style (16^th Edition):

Li, Su. “Living Polystyrene Anions Terminated with Difulvene.” 1991. Masters Thesis, McMaster University. Accessed March 08, 2021. http://hdl.handle.net/11375/19382.

MLA Handbook (7^th Edition):

Li, Su. “Living Polystyrene Anions Terminated with Difulvene.” 1991. Web. 08 Mar 2021.

Vancouver:

Li S. Living Polystyrene Anions Terminated with Difulvene. [Internet] [Masters thesis]. McMaster University; 1991. [cited 2021 Mar 08]. Available from: http://hdl.handle.net/11375/19382.

Council of Science Editors:

Li S. Living Polystyrene Anions Terminated with Difulvene. [Masters Thesis]. McMaster University; 1991. Available from: http://hdl.handle.net/11375/19382

23. Seddiki, Nadir. Import of macromolecules : structural studies of the Pesticin toxin and of an engineered variant : Import des macromelecules : analyses structurales de la toxine bactérienne pesticine et d'un derive hybride.

Degree: Docteur es, Microbiologie, biologie végétale et biotechnologies, 2010, Aix-Marseille 2

URL: http://www.theses.fr/2010AIX22077

►

Chez les bactéries à Gram-négatif, deux systèmes très bien conservés et essentiels à la survie de la cellule bactérienne ont été identifiés : les systèmes… (more)

▼

Chez les bactéries à Gram-négatif, deux systèmes très bien conservés et essentiels à la survie de la cellule bactérienne ont été identifiés : les systèmes Tol et TonB. Ces deux systèmes utilisent la force proton motrice, issue de la membrane interne et transfert l’énergie associée pour le transport actif de molécules (TonB) ou nécessaire au maintien de l’intégrité membranaire (Tol). Ces 2 systèmes ont été détournés de leurs fonctions initiales et parasités par les colicines, leur conférant un rôle primordial dans le mécanisme d’import de la colicine. Une colicine est une bactériocine (toxine) produite par Escherichia coli pour tuer des souches apparentées. Ce sont des toxines spécifiques et hautement actives. Cependant E.coli a développé des mécanismes de protection afin de résister à l’action cytotoxique des colicines. Ces mécanismes de résistance consistent essentiellement à produire des protéines d’immunité, qui vont pour la plupart se fixer sur le domaine catalytique de la colicine et l’empêcher d’exercer son action létale. La bactérie Yersinia pestis, agent de la peste, possède une colicin-like bactériocine, la pesticine, dont l’activité est de dégrader le peptidoglycane. L’action de la pesticine est inhibée par une protéine d’immunité, Pim, localisée dans le périplasme. Le principal objectif de ce projet est de comprendre les mécanismes d’inhibition de la pesticine par sa protéine d’immunité, grâce à des données biochimiques et structurales, mais aussi d’apporter des solutions pour contourner ce problème de résistance. La structure de la pesticine révèle des homologies structurales avec le T4 lysozyme du bactériophage T4. Pour contourner le problème de la résistance bactérienne liée à la protéine d’immunité, une solution a été de fusionner le domaine de réception/translocation de la pesticine avec le T4 lysozyme. Nous avons ainsi pu créer et résoudre la structure tridimensionnelle d’une protéine chimère fonctionnelle, capable de se fixer sur FyuA (récepteur de la pesticine) et tuer une souche exprimant ce récepteur et dont l’activité létale n’est pas inhibée par Pim.

In Gram-negative bacteria, two essential systems for cell survival have been characterized: the Tol and TonB system. Both Ton and Tol systems are very well conserved in Gram-negative bacteria and coupled to the proton motive force across the inner membrane, acting as energy transducers for active transport (Ton) or maintenance of outer envelope integrity (Tol). Both systems have been embezzled from their primary function and hijacked by colicins as part of the colicin killing pathway. Colicin is a bacteriocin (toxin) produced by and toxic to some strains of Escherichia coli. Colicins are highly effective toxins. However E.coli could develop protective mechanisms to resist to colicin cytotoxic effect. These mechanisms essentially consist to produce an immunity protein. These proteins bind to colicin catalytic domain and inhibit its lethal activity. Yersinia pestis, plague agent, possesses its own colicin-like bacteriocin, Pesticin, which degrades…

Advisors/Committee Members: Buchanan, Susan K. (thesis director), Lloubès, Roland (thesis director).

Subjects/Keywords: Importation de macromolecule; Resistance; Protéine d'immunité; Import of macromolecules; Tol and TonB sytems; Colicins; Resistance; Immunity protein; Pesticin; Pim; Reception; Translocation; FyuA; Chimera

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Seddiki, N. (2010). Import of macromolecules : structural studies of the Pesticin toxin and of an engineered variant : Import des macromelecules : analyses structurales de la toxine bactérienne pesticine et d'un derive hybride. (Doctoral Dissertation). Aix-Marseille 2. Retrieved from http://www.theses.fr/2010AIX22077

Chicago Manual of Style (16^th Edition):

Seddiki, Nadir. “Import of macromolecules : structural studies of the Pesticin toxin and of an engineered variant : Import des macromelecules : analyses structurales de la toxine bactérienne pesticine et d'un derive hybride.” 2010. Doctoral Dissertation, Aix-Marseille 2. Accessed March 08, 2021. http://www.theses.fr/2010AIX22077.

MLA Handbook (7^th Edition):

Seddiki, Nadir. “Import of macromolecules : structural studies of the Pesticin toxin and of an engineered variant : Import des macromelecules : analyses structurales de la toxine bactérienne pesticine et d'un derive hybride.” 2010. Web. 08 Mar 2021.

Vancouver:

Seddiki N. Import of macromolecules : structural studies of the Pesticin toxin and of an engineered variant : Import des macromelecules : analyses structurales de la toxine bactérienne pesticine et d'un derive hybride. [Internet] [Doctoral dissertation]. Aix-Marseille 2; 2010. [cited 2021 Mar 08]. Available from: http://www.theses.fr/2010AIX22077.

Council of Science Editors:

Seddiki N. Import of macromolecules : structural studies of the Pesticin toxin and of an engineered variant : Import des macromelecules : analyses structurales de la toxine bactérienne pesticine et d'un derive hybride. [Doctoral Dissertation]. Aix-Marseille 2; 2010. Available from: http://www.theses.fr/2010AIX22077

24. Sagou, Sagou Jean-Pierre. Influence de cations métalliques sur les propriétés physico-chimiques de carboxyméthyl-dextrane fonctionnalisé : Influence of metallic cations on physico-chemical properties of functionalized carboxymethyldextran macromolecules.

Degree: Docteur es, Géosciences, 2008, Lorraine INP

URL: http://www.theses.fr/2008INPL072N

►

Le présent travail est destiné à acquérir un ensemble de données expérimentales et quantitatives cohérentes sur le comportement physico-chimique d'un système constitué d'un polysaccharide linéaire,… (more)

▼

Le présent travail est destiné à acquérir un ensemble de données expérimentales et quantitatives cohérentes sur le comportement physico-chimique d'un système constitué d'un polysaccharide linéaire, flexible et chimiquement fonctionnalisé en groupements carboxyliques, le carboxyméthyl-dextrane (CMD) et d'un milieu ionique comportant des cations d'affinité variée pour ces fonctions : Na+, Ca2+ et Cd2+. La densité de sites et leur constante de dissociation - complexation ont été déterminées par titrage potentiométrique avec des électrodes spécifiques (proton et cadmium). Les propriétés électro-hydrodynamiques et les transitions conformationnelles ont été étudiées en combinant la conductimétrie, l'électrophorèse, la diffusion dynamique de lumière et la viscosimétrie. Enfin, la stabilité colloïdale en relation avec les interactions intermoléculaires a été étudiée par turbidimétrie et diffusion dynamique de lumière. En présence d'ions monovalents, le comportement du CMD, typique d’une particule microgel molle, est déterminé par la force ionique et la concentration en polysaccharide. A basse force ionique, le CMD est en condition de bon solvant lorsqu'il est peu concentré tandis que le recouvrement des doubles-couches électriques autour des macromolécules détermine les propriétés électro-hydrodynamiques du CMD en régime concentré. A haute salinité, les interactions électrostatiques intramoléculaires et interparticulaires sont négligeables, et la macromolécule a un comportement caractéristique de polymère en mauvais solvant à haute fraction volumique. En présence de cations divalents, le calcium, et plus encore le cadmium, entrent en compétition avec le proton pour l’occupation des sites carboxyliques, ce qui s’accompagne par une réorganisation locale des chaînes polymères. A haute force ionique, la taille élevée des agrégats, la vitesse initiale d'agrégation élevée, ainsi que la persistance d'une forte turbidité au maximum d'effet, suggèrent que les agrégats sont formés en régime de type agrégation limitée par la diffusion des particules (DLA)

The present work focused on the acquisition of experimental and quantitative data on the physico-chemical properties of a linear, flexible and chemically functionalized polysaccharide by carboxymethyl grafting, yielding carboxymethyldextran macromolecules (CMD) and an aqueous electrolyte containing various ions Na+, Ca2+ et Cd2+ with different chemical affinity for these chemical functions. Charge density and complexation – dissociation constants have been evaluated using specific electrodes-based potentiometric titration. The electro-hydrodynamic properties and the conformational transitions were examined through electrical conductivity increment measurements, electrophoresis, dynamic light scattering and viscosimetry. Also, colloidal stability has been investigated by means of turbidimetry and dynamic light scattering. In the presence of monovalent ions, the behaviour of CMD, typically that of a soft microgel particle, is strongly depending on ionic strength and polysaccharide…

Advisors/Committee Members: Thomas, Fabien (thesis director), Duval, Jérôme (thesis director).

Subjects/Keywords: Carboxyméthyl-dextrane; Macromolécule; Electro-hydrodynamique; Gonflement; Effet de solvant; Complexation; Interaction électrostatique; Carboxymethyldextran; Swelling; Solvent effect; Complexation; Macromolecule; Electro-hydrodynamic; Electrostatic interaction

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Sagou, S. J. (2008). Influence de cations métalliques sur les propriétés physico-chimiques de carboxyméthyl-dextrane fonctionnalisé : Influence of metallic cations on physico-chemical properties of functionalized carboxymethyldextran macromolecules. (Doctoral Dissertation). Lorraine INP. Retrieved from http://www.theses.fr/2008INPL072N

Chicago Manual of Style (16^th Edition):

Sagou, Sagou Jean-Pierre. “Influence de cations métalliques sur les propriétés physico-chimiques de carboxyméthyl-dextrane fonctionnalisé : Influence of metallic cations on physico-chemical properties of functionalized carboxymethyldextran macromolecules.” 2008. Doctoral Dissertation, Lorraine INP. Accessed March 08, 2021. http://www.theses.fr/2008INPL072N.

MLA Handbook (7^th Edition):

Sagou, Sagou Jean-Pierre. “Influence de cations métalliques sur les propriétés physico-chimiques de carboxyméthyl-dextrane fonctionnalisé : Influence of metallic cations on physico-chemical properties of functionalized carboxymethyldextran macromolecules.” 2008. Web. 08 Mar 2021.

Vancouver:

Sagou SJ. Influence de cations métalliques sur les propriétés physico-chimiques de carboxyméthyl-dextrane fonctionnalisé : Influence of metallic cations on physico-chemical properties of functionalized carboxymethyldextran macromolecules. [Internet] [Doctoral dissertation]. Lorraine INP; 2008. [cited 2021 Mar 08]. Available from: http://www.theses.fr/2008INPL072N.

Council of Science Editors:

Sagou SJ. Influence de cations métalliques sur les propriétés physico-chimiques de carboxyméthyl-dextrane fonctionnalisé : Influence of metallic cations on physico-chemical properties of functionalized carboxymethyldextran macromolecules. [Doctoral Dissertation]. Lorraine INP; 2008. Available from: http://www.theses.fr/2008INPL072N

Virginia Tech

25. Hogan, Shelly Patricia. Grape Extracts for Type 2 Diabetes Treatment Through Specific Inhibition of α-Glucosidase and Antioxidant Protection.

Degree: PhD, Food Science and Technology, 2009, Virginia Tech

URL: http://hdl.handle.net/10919/26725

► Research was conducted to investigate the effect of phenolic compounds derived from inherently rich antioxidant grape extracts (GE) on α-glucosidase inhibitory activity in vitro and… (more)

▼ Research was conducted to investigate the effect of phenolic compounds derived from inherently rich antioxidant grape extracts (GE) on α-glucosidase inhibitory activity in vitro and in vivo blood glucose control, oxidative stress, and inflammation associated with obesity-induced type 2 diabetes. Because intestinal α-glucosidase plays a key role in the digestion and absorption of complex carbohydrates, the inhibition of this enzyme is a metabolic target for managing diabetes by improving post-prandial blood glucose control. Initially, red Norton wine grape (Vitis aestivalis) and pomace extracts were evaluated and determined to have notable phenolic content and antioxidant properties. Next, grape skin (GSE) and pomace extract (GPE) were tested and both had in vitro yeast and mammalian α-glucosidase inhibitory activity. The GSE was 32-times more potent at inhibiting yeast α-glucosidase than acarbose, a commercial oral hypoglycemic agent. From HPLC and LC-MS analysis, three phenolics from the GSE (resveratrol, ellagic acid, and catechin) were identified as active inhibitory compounds. The acute administration of GPE (400 mg/kg bw) to mice reduced postprandial blood glucose level by 35% following an oral glucose tolerance test compared to the control. The daily supplementation (250 mg/kg bw) of GSE and GPE for 12-weeks to mice affected fasting blood glucose levels, oxidative stress, and inflammatory biomarkers associated with obesity and type 2 diabetes. At the end of the study, the GSE group gained significantly (P < 0.05) more weight (24.6 g) than the control, high fat, or GPE groups (11.2, 20.2, 19.6 g, respectively). Both GSE and GPE groups had lower fasting blood glucose levels (119.3 and 134.2 mg/dL, respectively) compared to the high fat group (144.6 mg/dL). The 12-week supplementation of GSE was associated with a higher plasma oxygen radical absorbance capacity (ORAC), lower liver lipid peroxidation as measure by TBARS, and lower levels of inflammation as measured by plasma C-reactive protein compared to the high fat group. In conclusion, our collective observations from these studies provide insight into the potential effects of antioxidant rich grape extracts on diabetes-related biomarkers through a dual mechanism of antioxidant protection and specific inhibition of intestinal α-glucosidases. Advisors/Committee Members: Zhou, Kequan Kevin (committeechair), Duncan, Susan E. (committee member), O'Keefe, Sean F. (committee member), Bevan, David R. (committee member), Liu, Dongmin (committee member).

Subjects/Keywords: oxidative stress; diabetes; bioactive phenolic compounds; α-glucosidase; enzyme kinetics; macromolecule; Functional foods

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Hogan, S. P. (2009). Grape Extracts for Type 2 Diabetes Treatment Through Specific Inhibition of α-Glucosidase and Antioxidant Protection. (Doctoral Dissertation). Virginia Tech. Retrieved from http://hdl.handle.net/10919/26725

Chicago Manual of Style (16^th Edition):

Hogan, Shelly Patricia. “Grape Extracts for Type 2 Diabetes Treatment Through Specific Inhibition of α-Glucosidase and Antioxidant Protection.” 2009. Doctoral Dissertation, Virginia Tech. Accessed March 08, 2021. http://hdl.handle.net/10919/26725.

MLA Handbook (7^th Edition):

Hogan, Shelly Patricia. “Grape Extracts for Type 2 Diabetes Treatment Through Specific Inhibition of α-Glucosidase and Antioxidant Protection.” 2009. Web. 08 Mar 2021.

Vancouver:

Hogan SP. Grape Extracts for Type 2 Diabetes Treatment Through Specific Inhibition of α-Glucosidase and Antioxidant Protection. [Internet] [Doctoral dissertation]. Virginia Tech; 2009. [cited 2021 Mar 08]. Available from: http://hdl.handle.net/10919/26725.

Council of Science Editors:

Hogan SP. Grape Extracts for Type 2 Diabetes Treatment Through Specific Inhibition of α-Glucosidase and Antioxidant Protection. [Doctoral Dissertation]. Virginia Tech; 2009. Available from: http://hdl.handle.net/10919/26725

The Ohio State University

26. Ihms, Elihu Carl. Integrative Investigation and Modeling of Macromolecular Complexes.

Degree: PhD, Biophysics, 2015, The Ohio State University

URL: http://rave.ohiolink.edu/etdc/view?acc_num=osu1429547886

► Many processes in biological systems are dependent upon complex regulatory schemes, often arranged in scale-free networks. Because of the difficulties in studying the nuanced behavior… (more)

▼ Many processes in biological systems are dependent upon complex regulatory schemes, often arranged in scale-free networks. Because of the difficulties in studying the nuanced behavior of such complicated systems, understanding the interactions between the individual nodes is essential to grasp the system as a whole. A highly productive example is the mechanism controlling tryptophan biosynthesis in Bacillus species. Thirty years of investigation into this system has resulted in paradigmatic examples of biosensors, response-amplification schemes, and closed-loop control.Despite this thorough inquest, many important processes within the TRAP system are still poorly understood; several are investigated with a variety of experimental techniques and analytical approaches in this work. One is the feedback rescue mechanism provided by the protein Anti-TRAP (AT) – although a crystal structure of a TRAP-AT complex is available, this static representation has proved to be misleading. Here, we show that the TRAP-Anti-TRAP interaction is actually quite complex, because the components the polydentate nature of each component leads to the formation of large heteropolymers at physiological ratios. These complexes are studied extensively with a broad range of structural, thermodynamic, and kinetic experiments.In addition to the complicated behavior they display in combination, the individual components themselves display fascinating properties that are tied to their regulatory function. Because TRAP is a homopolymer of eleven identical subunits, its activation by binding up to eleven tryptophans provides an unparalleled opportunity to examine binding cooperativity. The nature of this thermodynamic coupling mechanism is investigated in this work, leading to the realization that the presence of just a few bound tryptophan molecules causes profound changes in TRAP long before a majority of its active sites are occupied. AT, which also exists as a homopolymer of three identical subunits, can self-associate with an important effect on its regulatory properties. The assembly of AT subunits and their configurational dynamics are investigated in detail in this work, providing insight into not just the behavior of TRAP and Anti-TRAP, but oligomeric proteins as a whole.The exceptional complexity and quality of data provided by this system has necessitated the development and validation of new tools, as existing methods have often found to be inadequate. One of tbhe new tools described here, MESMER, provides a powerful and fully integrated analysis of heterogenous structural data, and has already started to find use in the scientific community. Advisors/Committee Members: Foster, Mark (Advisor).

Subjects/Keywords: Biochemistry; Biophysics; Molecular Physics; Molecules; Polymers; Macromolecular complexes; Integrative modeling; Computational biophysics; Reversible oligomerization; Quantitative modeling; Gene regulation networks; Macromolecule structure and configurational dynamics

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Ihms, E. C. (2015). Integrative Investigation and Modeling of Macromolecular Complexes. (Doctoral Dissertation). The Ohio State University. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=osu1429547886

Chicago Manual of Style (16^th Edition):

Ihms, Elihu Carl. “Integrative Investigation and Modeling of Macromolecular Complexes.” 2015. Doctoral Dissertation, The Ohio State University. Accessed March 08, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=osu1429547886.

MLA Handbook (7^th Edition):

Ihms, Elihu Carl. “Integrative Investigation and Modeling of Macromolecular Complexes.” 2015. Web. 08 Mar 2021.

Vancouver:

Ihms EC. Integrative Investigation and Modeling of Macromolecular Complexes. [Internet] [Doctoral dissertation]. The Ohio State University; 2015. [cited 2021 Mar 08]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=osu1429547886.

Council of Science Editors:

Ihms EC. Integrative Investigation and Modeling of Macromolecular Complexes. [Doctoral Dissertation]. The Ohio State University; 2015. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=osu1429547886

University of Michigan

27. Karanfil, Tanju. Oxygen sensitivity of natural and synthetic organic macromolecule sorption by activated carbon.

Degree: PhD, Health and Environmental Sciences, 1995, University of Michigan

URL: http://hdl.handle.net/2027.42/129624

► The influence of dissolved oxygen (DO) on the sorption of natural and synthetic dissolved organic matter (DOM) by granular activated carbon (GAC) was investigated. The… (more)

▼ The influence of dissolved oxygen (DO) on the sorption of natural and synthetic dissolved organic matter (DOM) by granular activated carbon (GAC) was investigated. The sorption behavior of six of the nine DOMs tested were significantly affected by the presence of DO; these six DOMs included polymaleic acid (PMA), peat humic acid, (PMA), Leonardite humic acid, Suwannee river fulvic acid, and Laurentian fulvic and humic acids. The sorption of Aldrich and Soil humic acids and polystyrene sulfonate (PSS) was not sensitive to the presence or absence of DO. Sensitivity of sorption to DO generally increased with decreasing molecular size, polydispersity, aromaticity and increasing acidity for the five natural DOMs. Sorption of the low molecular weight fractions of PHA, an oxygen-sensitive DOM, was almost twice as great as that of the whole material. Sorption of the low molecular weight fractions of Aldrich HA, an oxygen-insensitive DOM, did not show any sensitivity to oxygen. Investigation of the influence of aqueous chemistry on the oxygen sensitivity of DOM sorption revealed that PMA, PHA, and Laurentian fulvic acid sensitivities decreased with decreasing pH and with increasing ionic strength. This suggests that linear, flexible and open DOM molecular configurations are more sensitive to the presence of oxygen. Measurements of the oxygen sensitivity of PMA and Laurentian fulvic acid, and o-cresol sorption on different GAC surfaces indicated that oxygen sensitivity decreases markedly with increasing number of GAC surface functional (acid/base) groups, suggesting that polymerization occurs on surface sites other than those containing acidic or basic surface functional groups. The two raw materials from which the experimental carbons were produced, wood and coal, were found to influence oxygen sensitivity of DOM and o-cresol sorption differently. The similar trends observed for the two DOMs and the o-cresol used for this study indirectly indicate that the polymerization of DOMs and o-cresol occur on the similar surfaces. The effects of preloading of carbons with DOMs on the subsequent sorption of trichloroethylene (oxygen-insensitive) were observed to be greater when the preloading occurred under oxic conditions than under anoxic conditions, for the same degree of preloading. N₂-surface area measurements indicated that this difference is a result of the blockage of GAC pores by polymerized DOM molecules. Preloading was similarly found to decrease uptake of o-cresol (oxygen-sensitive) by 20% and 45% under anoxic and oxic conditions, respectively. Advisors/Committee Members: Jr., Walter J. Weber, (advisor).

Subjects/Keywords: Activated; Carbon; Dissolved Organic Matter; Fulvic Acid; Macromolecule; Natural; Oxygen; Peat Humic Acid; Polymaleic Acid; Sensitivity; Sorption; Synthetic

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Karanfil, T. (1995). Oxygen sensitivity of natural and synthetic organic macromolecule sorption by activated carbon. (Doctoral Dissertation). University of Michigan. Retrieved from http://hdl.handle.net/2027.42/129624

Chicago Manual of Style (16^th Edition):

Karanfil, Tanju. “Oxygen sensitivity of natural and synthetic organic macromolecule sorption by activated carbon.” 1995. Doctoral Dissertation, University of Michigan. Accessed March 08, 2021. http://hdl.handle.net/2027.42/129624.

MLA Handbook (7^th Edition):

Karanfil, Tanju. “Oxygen sensitivity of natural and synthetic organic macromolecule sorption by activated carbon.” 1995. Web. 08 Mar 2021.

Vancouver:

Karanfil T. Oxygen sensitivity of natural and synthetic organic macromolecule sorption by activated carbon. [Internet] [Doctoral dissertation]. University of Michigan; 1995. [cited 2021 Mar 08]. Available from: http://hdl.handle.net/2027.42/129624.

Council of Science Editors:

Karanfil T. Oxygen sensitivity of natural and synthetic organic macromolecule sorption by activated carbon. [Doctoral Dissertation]. University of Michigan; 1995. Available from: http://hdl.handle.net/2027.42/129624

28. Sherrell, Darren. Diffraction spectroscopy of metalloproteins.

Degree: 2014, University of Saskatchewan

URL: http://hdl.handle.net/10388/ETD-2014-03-1460

► X-ray absorption is not only element specific, but atom specific: two atoms of the same element in different states or in different neighbourhoods will have… (more)

Subjects/Keywords: X-ray Crystallography; X-Ray Absorption Spectroscopy; Diffraction Anomalous Fine Structure; Diffraction Spectroscopy; Metalloprotein; Redox; Macromolecule

…x29; and serves to explain the structure-function relationship of a macromolecule [9… …a macromolecule comes at a cost. For the protein’s three-dimensional structure to be… …crystallography are measurements of electron density of the macromolecule; atomic positions are located… …macromolecule.! ! 1.6! The Experiment! ! One of the driving forces behind these experiments is to…

10 more images…

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Sherrell, D. (2014). Diffraction spectroscopy of metalloproteins. (Thesis). University of Saskatchewan. Retrieved from http://hdl.handle.net/10388/ETD-2014-03-1460

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Sherrell, Darren. “Diffraction spectroscopy of metalloproteins.” 2014. Thesis, University of Saskatchewan. Accessed March 08, 2021. http://hdl.handle.net/10388/ETD-2014-03-1460.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Sherrell, Darren. “Diffraction spectroscopy of metalloproteins.” 2014. Web. 08 Mar 2021.

Vancouver:

Sherrell D. Diffraction spectroscopy of metalloproteins. [Internet] [Thesis]. University of Saskatchewan; 2014. [cited 2021 Mar 08]. Available from: http://hdl.handle.net/10388/ETD-2014-03-1460.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Sherrell D. Diffraction spectroscopy of metalloproteins. [Thesis]. University of Saskatchewan; 2014. Available from: http://hdl.handle.net/10388/ETD-2014-03-1460

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

29. Penner, Jacob. Magnetic Resonance Spectroscopy Investigations of Alzheimer Disease.

Degree: 2014, University of Western Ontario

URL: https://ir.lib.uwo.ca/etd/2190

► Alzheimer disease is a progressively devastating neurodegenerative disease of the brain that impairs cognition and is ultimately fatal. Cholinesterase inhibitors are the current standard treatment… (more)

Subjects/Keywords: Alzheimer disease; cholinesterase inhibitors; high magnetic field; macromolecule removal; Magnetic Resonance Spectroscopy; metabolite quantification; Medical Biophysics

…1.5.2 Echo time considerations .. �� 1.5.3 Macromolecule removal… …metabolite quantification incorporating subject-specific macromolecule removal 4.1 4.2 36 36 37 38… …subject-specific macromolecule removal �� .. 5.1.4 Conclusions… …metabolites following an inversion pulse �� …... �� . Full, macromolecule, and… …metabolite spectra following macromolecule removal .. Typical 7T in vivo 1H MR spectrum with fit…

9 more images…

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APA (6^th Edition):

Penner, J. (2014). Magnetic Resonance Spectroscopy Investigations of Alzheimer Disease. (Thesis). University of Western Ontario. Retrieved from https://ir.lib.uwo.ca/etd/2190

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Penner, Jacob. “Magnetic Resonance Spectroscopy Investigations of Alzheimer Disease.” 2014. Thesis, University of Western Ontario. Accessed March 08, 2021. https://ir.lib.uwo.ca/etd/2190.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Penner, Jacob. “Magnetic Resonance Spectroscopy Investigations of Alzheimer Disease.” 2014. Web. 08 Mar 2021.

Vancouver:

Penner J. Magnetic Resonance Spectroscopy Investigations of Alzheimer Disease. [Internet] [Thesis]. University of Western Ontario; 2014. [cited 2021 Mar 08]. Available from: https://ir.lib.uwo.ca/etd/2190.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Penner J. Magnetic Resonance Spectroscopy Investigations of Alzheimer Disease. [Thesis]. University of Western Ontario; 2014. Available from: https://ir.lib.uwo.ca/etd/2190

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

30. Chaaban, Abdul Amir. Etude de l'organisation structurale des nanocolloïdes humiques : Study of the structural organization of humic nanocolloids.

Degree: Docteur es, Hydrologie, hydrochimie, sol, environnement, 2016, Université Toulouse III – Paul Sabatier

URL: http://www.theses.fr/2016TOU30062

►

L'organisation des substances humiques à l'échelle moléculaire reste une question largement débattue, et à ce jour, il n'a pas été possible de trancher entre une… (more)

▼

L'organisation des substances humiques à l'échelle moléculaire reste une question largement débattue, et à ce jour, il n'a pas été possible de trancher entre une structure polymérique en pelotte plus ou moins flexible et un assemblage supramoléculaire de molecules hétérogènes associées par des liaisons hydrogènes et des interactions hydrophobes. Dans cette thèse, nous étudions la reconformation induite par l'addition de tensio-actifs cationiques (Chlorure de C n-trimethylammonium) sur une série de substances humiques (acides fulvique et humiques) ainsi que sur de la matière organique naturelle contenue dans des eaux noires. Des mesures de turbidité, de diffusion de lumière, mobilité électrophorétique, tension de surface, spectroscopie de fluorescence, diffusion des neutrons aux petits angles, et cryomicroscopie à transmission, permettent de decrire les complexes formés entre le tensio-actif et la matière humique. L'association matière humique/tensio-actif dépend à la fois d'interactions d'origine électrostatique et hydrophobe. Une série de structures moléculaires, vésicules, disques, globules, pseudo-micelles, est observée en cryomicroscopie selon la concentration en surfactant. La séquence obtenue est cohérente avec un système catanionique, en d'autres termes une partie de la matière humique est amphiphile et s'organise en assemblage supramoléculaire. L'addition de tensio-actif modifie également fortement le spectre de fluorescence de la matière humique, les nouvelles bandes bien résolues présentes sur le spectre indiquant une restructuration majeure de l'assemblage supramoléculaire.

The structural organization of humic nanocolloids remains a matter of harsh debate, and surprisingly, it is yet not possible to decide between an arrangement of the humic matter in the form of randomly coiled macromolecules more or less connected, and a supramolecular organization of small heterogeneous molecules linked by hydrogen bonds and hydrophobic interactions. In this study, we investigate the reconformation induced by the addition of cationic surfactants (C n-trimethylammonium chloride) of varying alkyl chain length with a series of humic substances (HS) and Dissolved Organic matter (DOM) from two blackwater rivers of the Central Amazon. Turbidity measurements, Dynamic light scattering, electrophoretic mobility, surface tension, fluorescence spectroscopy, small angle neutron scattering and cryo-transmission electron microscopy (cryo-TEM), are combined to describe the Humic Substance/Surfactant complexes obtained. The association between the oppositely charged HS and cationic surfactant is driven by both electrostatic and hydrophobic interactions. A variety of molecular structures, unilamellar vesicles, disks, globules, spheroidal micelles, are visualized by cryo-TEM depending on surfactant concentration. Such sequence, consistent with those displayed by catanionic systems, provides an independent confirmation of both the amphiphilic nature of HS and of its supramolecular organization. In addition, the molecular rearrangement…

Advisors/Committee Members: Lartiges, Bruno (thesis director), Saad, Zeinab (thesis director), Kazpard, Véronique (thesis director).

Subjects/Keywords: Substances humiques; Tensioactif cationique; Organisation structurelle; Polymère macromolécule; Supramoléculaire; Cryogénique microscopie; Électronique à transmission; Spectroscopie de fluorescence; Humic substances; Cationic surfactant; Structural organization; Polymer macromolecule; Cryogenic tranmission electron microscopy; Fluorescence spectroscopy

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Chaaban, A. A. (2016). Etude de l'organisation structurale des nanocolloïdes humiques : Study of the structural organization of humic nanocolloids. (Doctoral Dissertation). Université Toulouse III – Paul Sabatier. Retrieved from http://www.theses.fr/2016TOU30062

Chicago Manual of Style (16^th Edition):

Chaaban, Abdul Amir. “Etude de l'organisation structurale des nanocolloïdes humiques : Study of the structural organization of humic nanocolloids.” 2016. Doctoral Dissertation, Université Toulouse III – Paul Sabatier. Accessed March 08, 2021. http://www.theses.fr/2016TOU30062.

MLA Handbook (7^th Edition):

Chaaban, Abdul Amir. “Etude de l'organisation structurale des nanocolloïdes humiques : Study of the structural organization of humic nanocolloids.” 2016. Web. 08 Mar 2021.

Vancouver:

Chaaban AA. Etude de l'organisation structurale des nanocolloïdes humiques : Study of the structural organization of humic nanocolloids. [Internet] [Doctoral dissertation]. Université Toulouse III – Paul Sabatier; 2016. [cited 2021 Mar 08]. Available from: http://www.theses.fr/2016TOU30062.

Council of Science Editors:

Chaaban AA. Etude de l'organisation structurale des nanocolloïdes humiques : Study of the structural organization of humic nanocolloids. [Doctoral Dissertation]. Université Toulouse III – Paul Sabatier; 2016. Available from: http://www.theses.fr/2016TOU30062

Open Access Theses and Dissertations