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You searched for subject:(Macrocytosis). Showing records 1 – 3 of 3 total matches.

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University of the Western Cape

1. Mutenda, Nicholus Mbangu. Adverse effects experienced by patients on first line antiretroviral drugs used at Keetmanshoop Hospital (Namibia).

Degree: 2015, University of the Western Cape

Adverse effects are a significant factor that determine how long patients will tolerate a given antiretroviral drug regimen. They also influence treatment options, and play an important role in the much needed adherence to treatment by patients on Highly Active Antiretroviral Therapy (HAART). This study is aimed at understanding adverse effects experienced by patients on the first line antiretroviral therapy at Keetmanshoop Hospital in Namibia. Methods : A retrospective quantitative method was used to review records of patients on first line antiretroviral treatment who started treatment between November 1st 2007 and December 1st, 2008 and followed up until they reached 36 – 48 months on treatment. Records of 94 patients were found eligible to be included in the study. Data was analysed using Stata 12 data analysis software. Results : The most reported adverse effect was musculoskeletal disorders (25%) whereas headache (16%) was the least reported. Low haemoglobin (78%) was the most common recorded hematologic adverse effect whereas low red cell distribution width and low mean platelet volume were the least recorded adverse effects (0%). A Male patient was more likely to experience a low haemoglobin levels compared to a female patient (adjusted OR: 3.29, 95% CI: 1.3 – 8.3). A male patient was found to be 64% times less likely to experience a higher mean cell haemoglobin compared to a female patient (adjusted OR. 0.31, 95% CI: 0.11 – 0.87). A patient on nevirapine was more likely to experience an elevated creatinine level compared to a patient on efavirenz (adjusted OR; 36.0, 95%CI: 2.02 – 62.5). At baseline, a patient who had prior exposure to ART had an 81 times (adjusted OR: 81.4, 95%CI: 5.3 – 119, p-value=0.00) increased odds of experiencing a high mean cell volume (MCV) compared to a patient with no ART exposure. A patient with a higher CD4 count was also less likely to experience a low hemoglobin compared to a patient with low CD4 count (adjusted OR; 0.31, 95% CI: 0.12 – 0.77). The author recommends further studies with higher sample size to confirm whether higher creatinine levels are more prevalent in patients on nevirapine compared to patients on efavirenz; this will have clinical implications especially in patients with impaired renal system. Antiretroviral treatment increases chances of developing macrocytosis anaemia; clinical implication of this condition may need to be investigated. Advisors/Committee Members: Mugabo, Pierre (advisor).

Subjects/Keywords: Macrocytosis anaemia; Highly active antiretroviral therapy; Antiretroviral Therapy, Highly Active; Nevirapine

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Mutenda, N. M. (2015). Adverse effects experienced by patients on first line antiretroviral drugs used at Keetmanshoop Hospital (Namibia). (Thesis). University of the Western Cape. Retrieved from http://hdl.handle.net/11394/4549

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Mutenda, Nicholus Mbangu. “Adverse effects experienced by patients on first line antiretroviral drugs used at Keetmanshoop Hospital (Namibia). ” 2015. Thesis, University of the Western Cape. Accessed October 15, 2019. http://hdl.handle.net/11394/4549.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Mutenda, Nicholus Mbangu. “Adverse effects experienced by patients on first line antiretroviral drugs used at Keetmanshoop Hospital (Namibia). ” 2015. Web. 15 Oct 2019.

Vancouver:

Mutenda NM. Adverse effects experienced by patients on first line antiretroviral drugs used at Keetmanshoop Hospital (Namibia). [Internet] [Thesis]. University of the Western Cape; 2015. [cited 2019 Oct 15]. Available from: http://hdl.handle.net/11394/4549.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Mutenda NM. Adverse effects experienced by patients on first line antiretroviral drugs used at Keetmanshoop Hospital (Namibia). [Thesis]. University of the Western Cape; 2015. Available from: http://hdl.handle.net/11394/4549

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation


Tampere University

2. Latvala, Jaana. Effect of alcohol consumption and acetaldehyde on blood cells and molecules: pathogenic and diagnostic implications .

Degree: Lääketieteen laitos - Medical School, 2004, Tampere University

Väitöstutkimuksessa selvitettiin etanolin ja sen ensimmäisen hajoamistuotteen, asetaldehydin, veren soluille ja molekyyleille aiheuttamia muutoksia. Tutkimuksilla on merkitystä alkoholin aiheuttamien kudosvaurioiden mekanismien selvittelyssä sekä kehitettäessä uusia menetelmiä alkoholin suurkulutuksen toteamiseksi aikaisempaa varhaisemmassa vaiheessa. Asetaldehydi on erittäin reaktiivinen molekyyli, joka voi muodostaa sidostuotteita monien erilaisten valkuaisaineitten kanssa. Alkoholin suurkuluttajien verenkierrossa havaittiin tällaisia sidostuotteita sekä niitä vastaan muodostuneita, erityisesti IgA-luokan vasta-aineita. Koe-eläimissä tuotetuilla asetaldehydin ja proteiinien välisiä sidoksia tunnistavilla vasta-aineilla selvitettiin myös mahdollisuuksia uusien alkoholin suurkulutusta kuvaavien testien käyttöönottoon. Esimerkiksi asetaldehydin ja VLDL-kolesterolin välisiin sidostuotteisiin kohdistuva vasta-aine osoittautui tehokkaaksi pienillä asetaldehydipitoisuuksilla valmistettujen kondensaattien tunnistamisessa. Tämä havainto voi avata uusia mahdollisuuksia alkoholin liikakäytön toteamiseksi. Myös alkoholin käytön aiheuttamat autoimmuunivasteet voivat tutkimuksen mukaan osoittautua hyödyllisiksi esimerkiksi erilaisten maksasairauksien erottelussa. Paljon alkoholia käyttävillä henkilöillä havaittiin veressä ja luuytimessä punasolujen ja niiden esiasteiden sisältävän asetaldehydin muovaamia rakenteita. Ne saattavat olla vaikuttamassa punasolujen poikkeavuuksien syntyyn alkoholisteilla. Alkoholin suurkuluttajille on tyypillistä että verenkierron punasolut ovat kooltaan tavanomaista suurempia ja punasolujen keskitilavuus (MCV) on suurentunut. Myös veren muiden solulinjojen poikkeavat määrät ovat tavallisia. Vähäiset verihiutaleitten määrät olivat alkoholisteilla yleisempiä kuin raittiilla verrokeilla tai kohtuukäyttäjillä. Luuytimessä alkoholin suurkuluttajilla on usein poikkeavaa rautakertymää sisältäviä punasoluja sekä poikkeavaa morfologiaa, mm. ylimääräistä sytoplasmista vakuolisaatiota, punasolujen ja verihiutaleitten esiasteissa voimakkaan päihtymyksen jälkeen. Tämän perusteella potilailta, joilla nämä arvot ovat poikkeavia, tulisi aina kysyä alkoholin käyttötottumuksista.; Alcohol abuse is known to have a wide array of adverse effects on serum proteins, blood cells and their progenitors in bone marrow. The mechanisms by which it does so have not yet been estab-lished, however. Recent studies have suggested that acetaldehyde, the first metabolite of ethanol, is responsible for many of its harmful effects, being a highly reactive molecule and capable of forming stable condensates with proteins and cellular constituents. Acetaldehyde-derived protein conden-sates have also been suggested as possible new markers of alcohol abuse. The present work is focused on the effects of ethanol and acetaldehyde on blood cells and pro-teins. The formation of acetaldehyde-derived protein modifications in vivo was studied using anti-bodies recognizing acetaldehyde-modified epitopes in proteins independently of the nature…

Subjects/Keywords: alkoholi; etanoli; makrosytoosi; lipoproteiini; autovasta-aine; alcohol; ethanol; macrocytosis; lipoprotein; autoantibody

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Latvala, J. (2004). Effect of alcohol consumption and acetaldehyde on blood cells and molecules: pathogenic and diagnostic implications . (Doctoral Dissertation). Tampere University. Retrieved from https://trepo.tuni.fi/handle/10024/67269

Chicago Manual of Style (16th Edition):

Latvala, Jaana. “Effect of alcohol consumption and acetaldehyde on blood cells and molecules: pathogenic and diagnostic implications .” 2004. Doctoral Dissertation, Tampere University. Accessed October 15, 2019. https://trepo.tuni.fi/handle/10024/67269.

MLA Handbook (7th Edition):

Latvala, Jaana. “Effect of alcohol consumption and acetaldehyde on blood cells and molecules: pathogenic and diagnostic implications .” 2004. Web. 15 Oct 2019.

Vancouver:

Latvala J. Effect of alcohol consumption and acetaldehyde on blood cells and molecules: pathogenic and diagnostic implications . [Internet] [Doctoral dissertation]. Tampere University; 2004. [cited 2019 Oct 15]. Available from: https://trepo.tuni.fi/handle/10024/67269.

Council of Science Editors:

Latvala J. Effect of alcohol consumption and acetaldehyde on blood cells and molecules: pathogenic and diagnostic implications . [Doctoral Dissertation]. Tampere University; 2004. Available from: https://trepo.tuni.fi/handle/10024/67269

3. Τσαντές, Αργύριος. Διερεύνηση της ερυθροποιητικής απάντησης στην υποξαιμία ατόμων με χρόνιες πνευμονοπάθειες.

Degree: 2002, National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ)

The aim of this study is to investigate the erythropoietic response to hypoxemia in chronic pulmonary disease. The study includes three parts: 1. Macrocytosis is a common finding in patients with chronic obstructive pulmonary disease (COPD). The cause for the elevation of MCV in these patients remains elusive. In an attempt to determine the extent of macrocytosis in COPD patients and search for possible causative factors, we evaluated the hematologic parameters, F cell percentage, blood gases and serum Epo levels in 32 COPD clinically stable patients and 34 sex- and age-matched non-smoker healthy volunteers. An increased MCV was observed in almost half of the hypoxemic COPD cases (14/32 or 43.75%), while erythrocytosis developed to a lesser degree (37.5%). The erythropoietic response did not correlate with the severity of hypoxia. Moreover, no significant correlation was found between macrocytosis and hypoxemia or erythrocytosis and red cell size. In some cases the two phenomena occurred independently. The F cell percentage was significantly elevated in the COPD group (p<0.01) and was associated with MCV values (n=32, r=0.41, p<0.05). This finding supports the hypothesis we put forward to explain the macrocytosis often observed in COPD, i.e., that the acute erythropoietic stress occurring repeatedly in these patients as a result of the frequent exacerbations may lead to waves of release of relatively immature red cells from the marrow, including an increased number of F-cells, reflecting the recruitment of normally dormant BFU- E, which maintain the program for γ-chain synthesis. The fact that erythrocytosis and macrocytosis, both being triggered by hypoxemia, do not occur consistently in all COPD patients indicates that many other factors may also intervene. 2. Long treatment with theophylline is often followed by a reduction of Hb levels, which is usually ascribed to the antagonistic activity between theophylline and adenosine (ADO) which leads to decreased Epo synthesis. This view is not unanimously accepted and several alternative explanations have been proposed. To evaluate the influence of theophylline on erythropoiesis in COPD we evaluated the hematologic parameters and Epo values in 32 patients with this condition. Twelve of them had been treated with theophylline (8mg/kg, daily) for at least 1 year; the other 20 patients had never received this drug. The severity of respiratory insufficiency was almost comparable in the 2 groups. A group of 34 sex- and age-matched healthy volunteers served as controls. Our findings failed to show any significant difference of the Hb and serum Epo values between the 2 COPD groups (treated and untreated). To further explore the underlying mechanisms, we studied the development of BFU-E-derived colonies in semisolid methylcellulose cultures in blood samples from 7 patients randomly selected from the above two groups. In addition, we studied the effects of theophylline on the erythroid cell development by adding this agent in erythroid cell cultures from 6 healthy volunteers at…

Subjects/Keywords: Ερυθροποίηση; Χρόνια αποφρακτική πνευμονοπάθεια (ΧΑΠ); Μακροκυττάρωση; Ερυθροποιηικό στρες; Ερυθροποιητίνη; Κύτταρα F; Erythropoiesis; Chronic obstructive pulmonary disease (COPD); Macrocytosis; Erythropoietic stress; Erythropoietin; F cells

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Τσαντές, . . (2002). Διερεύνηση της ερυθροποιητικής απάντησης στην υποξαιμία ατόμων με χρόνιες πνευμονοπάθειες. (Thesis). National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ). Retrieved from http://hdl.handle.net/10442/hedi/22515

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Τσαντές, Αργύριος. “Διερεύνηση της ερυθροποιητικής απάντησης στην υποξαιμία ατόμων με χρόνιες πνευμονοπάθειες.” 2002. Thesis, National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ). Accessed October 15, 2019. http://hdl.handle.net/10442/hedi/22515.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Τσαντές, Αργύριος. “Διερεύνηση της ερυθροποιητικής απάντησης στην υποξαιμία ατόμων με χρόνιες πνευμονοπάθειες.” 2002. Web. 15 Oct 2019.

Vancouver:

Τσαντές . Διερεύνηση της ερυθροποιητικής απάντησης στην υποξαιμία ατόμων με χρόνιες πνευμονοπάθειες. [Internet] [Thesis]. National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ); 2002. [cited 2019 Oct 15]. Available from: http://hdl.handle.net/10442/hedi/22515.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Τσαντές . Διερεύνηση της ερυθροποιητικής απάντησης στην υποξαιμία ατόμων με χρόνιες πνευμονοπάθειες. [Thesis]. National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ); 2002. Available from: http://hdl.handle.net/10442/hedi/22515

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

.