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You searched for subject:(MST1 2). Showing records 1 – 3 of 3 total matches.

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NSYSU

1. Li, Yu-wei. The role of Mst1/Mst2 in early brain development and glioblastoma formation of the mice.

Degree: Master, Institute of Biomedical Sciences, 2016, NSYSU

Glioblastoma multiforme (GBM) is the most aggressive and malignant primary brain tumor. Primary glioblastomas have a worse prognosis with a median survival of less than 2 years after diagnosis. The Hippo signaling transduction pathway plays multiple functions during organ development, adult tissues homeostasis and tumorigenesis, and its downstream mediator yes-associated protein 1 (YAP1) is known to function as a potent oncogene, which is amplified and overexpressed in various human cancers. The goal of this study is to study the role of Hippo pathway in GBM carcinogenesis. First, we selected primary murine glioblastoma cancer cell lines as an in vitro model system to study the functional roles of Hippo pathway in regulating the proliferation, adhesion and migration of GBM cells in vitro. Second, to identify the role of Hippo pathway in brain development, we selected GFAP drive Cre transgenic system to cross with conditional Mst1/Mst2 loxp mice to specific knockout Mst1/Mst2 (upstream kinases of Hippo pathway) expression in the glial cells during brain development. Moreover, to discovery the important function of the Hippo signaling involved in the development of GBM, we have established mouse models of GBM (activation of KrasG12D combined with p53 loss) for studying the critical roles of Hippo pathway in GBM progression. An understanding of the temporal regulation of Hippo during GBM progression and the identification of activation Hippo signaling combined p53 induced a transcriptional profilesâ with respect to upstream activators and downstream networks, which may play an important node in the design of clinical approaches targeting Hippo signaling for the treatment of GBM. Advisors/Committee Members: Hung-Wen Huamg (chair), Chen, Chun-Lin (chair), Kuang-hung Cheng (committee member).

Subjects/Keywords: Mouse model; Glioma; YAP1; MST1/2; Hippo pathway; Glioblastoma; Apoptosis; Verteporfin

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APA (6th Edition):

Li, Y. (2016). The role of Mst1/Mst2 in early brain development and glioblastoma formation of the mice. (Thesis). NSYSU. Retrieved from http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0628116-114955

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Li, Yu-wei. “The role of Mst1/Mst2 in early brain development and glioblastoma formation of the mice.” 2016. Thesis, NSYSU. Accessed April 15, 2021. http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0628116-114955.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Li, Yu-wei. “The role of Mst1/Mst2 in early brain development and glioblastoma formation of the mice.” 2016. Web. 15 Apr 2021.

Vancouver:

Li Y. The role of Mst1/Mst2 in early brain development and glioblastoma formation of the mice. [Internet] [Thesis]. NSYSU; 2016. [cited 2021 Apr 15]. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0628116-114955.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Li Y. The role of Mst1/Mst2 in early brain development and glioblastoma formation of the mice. [Thesis]. NSYSU; 2016. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0628116-114955

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation


University of Guelph

2. Carvajal, Diana. Role of Hippo Signaling Pathway During Bovine Oocyte Maturation In-Vitro.

Degree: MS, Department of Biomedical Sciences, 2018, University of Guelph

Oocyte development is strictly regulated by several ovarian signaling pathways. One of these pathways is the Hippo signaling pathway, known for its role in cell proliferation and apoptosis. Limited but substantial evidence has demonstrated that the Hippo signaling pathway plays a significant role in ovarian function. However, its involvement during specific stages of oocyte development remains elusive. This is the first report characterizing the expression and protein localization of Hippo pathway components during bovine oocyte maturation. Results provide new knowledge that the Hippo signaling pathway is involved during oocyte maturation in bovine species, and that the expression and localization of the components depend greatly on the presence or absence of cumulus cells and on specific stages of development. Results also provide insight about the role of cumulus cells in modulating pathway components and the importance of these components during oocyte maturation, which contribute to the development of competent oocytes. Advisors/Committee Members: Madan, Pavneesh (advisor).

Subjects/Keywords: Hippo signaling pathway; MST1/2; LATS1/2; YAP; TAZ; Oocyte maturation; Bovine

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Carvajal, D. (2018). Role of Hippo Signaling Pathway During Bovine Oocyte Maturation In-Vitro. (Masters Thesis). University of Guelph. Retrieved from https://atrium.lib.uoguelph.ca/xmlui/handle/10214/14579

Chicago Manual of Style (16th Edition):

Carvajal, Diana. “Role of Hippo Signaling Pathway During Bovine Oocyte Maturation In-Vitro.” 2018. Masters Thesis, University of Guelph. Accessed April 15, 2021. https://atrium.lib.uoguelph.ca/xmlui/handle/10214/14579.

MLA Handbook (7th Edition):

Carvajal, Diana. “Role of Hippo Signaling Pathway During Bovine Oocyte Maturation In-Vitro.” 2018. Web. 15 Apr 2021.

Vancouver:

Carvajal D. Role of Hippo Signaling Pathway During Bovine Oocyte Maturation In-Vitro. [Internet] [Masters thesis]. University of Guelph; 2018. [cited 2021 Apr 15]. Available from: https://atrium.lib.uoguelph.ca/xmlui/handle/10214/14579.

Council of Science Editors:

Carvajal D. Role of Hippo Signaling Pathway During Bovine Oocyte Maturation In-Vitro. [Masters Thesis]. University of Guelph; 2018. Available from: https://atrium.lib.uoguelph.ca/xmlui/handle/10214/14579


University of Guelph

3. Sharma, Jyoti. Role Of Hippo Signaling Pathway In Bovine Preimplantation Embryo Development.

Degree: MS, Department of Biomedical Sciences, 2016, University of Guelph

Blastocyst formation is an important milestone in preimplantation embryo development. During murine preimplantation embryogenesis, the Hippo signaling pathway is known to play a significant role in lineage segregation and henceforth the formation of blastocyst. However, the role of this cell-signaling pathway during bovine embryogenesis remains elusive. Thus, the aim of present study was to characterize Hippo signaling pathway during bovine preimplantation embryo development. mRNA transcripts of Hippo signaling pathway constituents (Crb3, Mst2, Yap1 and Taz) were observed during all the stages of bovine preimplantation embryo development. In order to evaluate the localization of Hippo pathway components, embryos at timed stages of development were stained using specific antibodies and observed with laser confocal microscope. While MST1/2 proteins were located in the cytoplasm during various stages of bovine embryonic development, TAZ and p-YAP were detected in the nucleus during morula and blastocyst stages. Localization of TAZ and p-YAP proteins were distinct in the bovine model as compared to the mouse model, suggesting the Hippo signaling pathway to be regulated differently in early bovine embryos. Oxidative stress is known to be an important factor causing the activation of Hippo signaling pathway in mice. No significant effect of oxidative stress was observed on the gene expression profile and the protein expression of Hippo signaling pathway constituents on treatment with H2O2 or Catalase in bovine preimplantation. embryogenesis. These results suggest that oxidative stress factor might not be an eminent factor affecting the expression of Hippo signaling pathway constituents in early bovine embryogenesis. Advisors/Committee Members: Madan, Pavneesh (advisor).

Subjects/Keywords: Preimplantation embryo development; Blastocyst; Trophectoderm; Inner Cell Mass; Hippo signaling pathway; MST1/2 Kinase; LATS1/2 Kinase; YAP1; TAZ

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Sharma, J. (2016). Role Of Hippo Signaling Pathway In Bovine Preimplantation Embryo Development. (Masters Thesis). University of Guelph. Retrieved from https://atrium.lib.uoguelph.ca/xmlui/handle/10214/9998

Chicago Manual of Style (16th Edition):

Sharma, Jyoti. “Role Of Hippo Signaling Pathway In Bovine Preimplantation Embryo Development.” 2016. Masters Thesis, University of Guelph. Accessed April 15, 2021. https://atrium.lib.uoguelph.ca/xmlui/handle/10214/9998.

MLA Handbook (7th Edition):

Sharma, Jyoti. “Role Of Hippo Signaling Pathway In Bovine Preimplantation Embryo Development.” 2016. Web. 15 Apr 2021.

Vancouver:

Sharma J. Role Of Hippo Signaling Pathway In Bovine Preimplantation Embryo Development. [Internet] [Masters thesis]. University of Guelph; 2016. [cited 2021 Apr 15]. Available from: https://atrium.lib.uoguelph.ca/xmlui/handle/10214/9998.

Council of Science Editors:

Sharma J. Role Of Hippo Signaling Pathway In Bovine Preimplantation Embryo Development. [Masters Thesis]. University of Guelph; 2016. Available from: https://atrium.lib.uoguelph.ca/xmlui/handle/10214/9998

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