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Degree: h_md  Dates: Last 2 Years

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University of Birmingham

1. Whitters, Deborah. The role of impaired serum bactericidal activity in chronic pseudomonas aeruginosa infection in non cystic fibrosis bronchiectasis .

Degree: h_md, College of Medical & Dental Sciences, 2018, University of Birmingham

Non Cystic Fibrosis bronchiectasis is characterised by perpetual neutrophilic inflammation in the lungs. The ongoing vicious cycle of bronchiectasis leads to further damage to already damaged airways and is a culmination of repeated infection, inflammation and failure of the host response to maintain sterility of the airway, despite a sophisticated innate and adaptive immune system. Pseudomonas aeruginosa commonly colonises the lungs of patients with bronchiectasis. I hypothesised that the concept of inhibitory antibodies in the serum may be a feature of Pseudomonas aeruginosa colonisation through a specific interaction between the host adaptive immune system and strain specific features. Here I have identified a mechanism where some patients colonised with Pseudomonas aeruginosa produce IgG2 antibodies specifically against the O antigen of bacterial LPS, which rather than promote complement-mediated killing actually inhibits it.

Subjects/Keywords: R Medicine (General)

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Whitters, D. (2018). The role of impaired serum bactericidal activity in chronic pseudomonas aeruginosa infection in non cystic fibrosis bronchiectasis . (Thesis). University of Birmingham. Retrieved from http://etheses.bham.ac.uk//id/eprint/8548/

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Whitters, Deborah. “The role of impaired serum bactericidal activity in chronic pseudomonas aeruginosa infection in non cystic fibrosis bronchiectasis .” 2018. Thesis, University of Birmingham. Accessed January 23, 2020. http://etheses.bham.ac.uk//id/eprint/8548/.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Whitters, Deborah. “The role of impaired serum bactericidal activity in chronic pseudomonas aeruginosa infection in non cystic fibrosis bronchiectasis .” 2018. Web. 23 Jan 2020.

Vancouver:

Whitters D. The role of impaired serum bactericidal activity in chronic pseudomonas aeruginosa infection in non cystic fibrosis bronchiectasis . [Internet] [Thesis]. University of Birmingham; 2018. [cited 2020 Jan 23]. Available from: http://etheses.bham.ac.uk//id/eprint/8548/.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Whitters D. The role of impaired serum bactericidal activity in chronic pseudomonas aeruginosa infection in non cystic fibrosis bronchiectasis . [Thesis]. University of Birmingham; 2018. Available from: http://etheses.bham.ac.uk//id/eprint/8548/

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

2. Altaf, Quratul-ain. Sleep in patients with type 2 diabetes: the impact of sleep apnoea, sleep duration, and sleep quality on clinical outcomes.

Degree: h_md, College of Medical & Dental Sciences, 2018, University of Birmingham

Introduction: Type 2 Diabetes (T2DM) and sleep-related disorders share common risk factors such as obesity; but the interrelationships between T2DM and sleep disorders are not well examined. Aims: In this thesis I aimed to assess: 1. The longitudinal impact of obstructive sleep apnoea (OSA) on micro vascular complications in patient with T2DM. 2. The relationship between sleep quality, sleep duration and adiposity in patients with T2DM Methods: To examine the first aim, I utilized the data collected from a previous project that examined the cross-sectional associations between OSA and micro vascular complications in patients with T2DM and followed up the study participants longitudinally using 1-2-1 interviews and electronic health records. For aim 2, I conducted a crosssectional study in patients with young-onset T2DM who were recruited from Heart of England NHS Foundation Trust and primary care. Result: For Aim 1: Depending on the micro vascular outcome examined, we had approximately 200 patients in the analysis. Patients were followed up for 2.5 years for renal outcomes, and 4-4.5 years for retinopathy and neuropathy outcomes. The prevalence of OSA was 63%. I found that baseline OSA was significantly associated with greater decline of eGFR and greater progression to pre-proliferative and proliferative retinopathy. I also found that OSA was associated with progression to a combined outcome of foot insensitivity or diabetic foot ulceration but this was a non-significant trend (p=0.06). In addition, I found that patients who received and were compliant with continuous positive airway pressure (CPAP) treatment (delivered during routine care) had improvements in heart rate variability parameters by study end. For Aim 2: Poor sleep quality and shorter sleep duration were associated with increased total body fat% after adjustment for potential confounders. Conclusion: I found that OSA plays an important role in the progression of micro vascular complications in patients with T2DM. Whether treatment with CPAP has a favourable impact on micro vascular complications is currently being examined in a randomized controlled trial. I also found that sleep duration and quality are associated with increased adiposity. The direction of this relationship need to be examined in longitudinal studies and interventional trials.

Subjects/Keywords: QH301 Biology; R Medicine (General)

…free fatty acids FML: F-wave minimal latency FRF: fundamental respiratory frequency GAP… 

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Altaf, Q. (2018). Sleep in patients with type 2 diabetes: the impact of sleep apnoea, sleep duration, and sleep quality on clinical outcomes. (Thesis). University of Birmingham. Retrieved from http://etheses.bham.ac.uk//id/eprint/8270/

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Altaf, Quratul-ain. “Sleep in patients with type 2 diabetes: the impact of sleep apnoea, sleep duration, and sleep quality on clinical outcomes.” 2018. Thesis, University of Birmingham. Accessed January 23, 2020. http://etheses.bham.ac.uk//id/eprint/8270/.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Altaf, Quratul-ain. “Sleep in patients with type 2 diabetes: the impact of sleep apnoea, sleep duration, and sleep quality on clinical outcomes.” 2018. Web. 23 Jan 2020.

Vancouver:

Altaf Q. Sleep in patients with type 2 diabetes: the impact of sleep apnoea, sleep duration, and sleep quality on clinical outcomes. [Internet] [Thesis]. University of Birmingham; 2018. [cited 2020 Jan 23]. Available from: http://etheses.bham.ac.uk//id/eprint/8270/.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Altaf Q. Sleep in patients with type 2 diabetes: the impact of sleep apnoea, sleep duration, and sleep quality on clinical outcomes. [Thesis]. University of Birmingham; 2018. Available from: http://etheses.bham.ac.uk//id/eprint/8270/

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

.