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You searched for subject:(Lutalyse). Showing records 1 – 2 of 2 total matches.

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1. Potter, Kaleigh Marie. Comparison of Serial PGF2α Protocols for Control of the Estrous Cycle in Mares.

Degree: Master of Natural and Applied Science in Agriculture, School of Agriculture, 2017, Missouri State University

Prostaglandin F2α is commonly administered to manipulate the estrous cycle in mares, at a dosage of dinoprost tromethamine (Lutalyse®) at 10 mg, administered IM. My objectives were to compare three serial low-dose PGF2α protocols, and determine the most effective treatment in terms of number of injections, intensity of protocol, time allocated, and labor. Quarter Horse mares (n=11) were used in a crossover design. Lutalyse was administered at 1.1 mL per injection: treatment 1- PGF2α once 6d post-ovulation; treatment 2- PGF2α twice daily 0 d, 1 d, and 2 d, then once 3 d and 4 d post- ovulation; treatment 3- PGF2α twice daily on 2 d, then once 3 d and 4 d post- ovulation. Teasing scores were assigned daily. Rectal palpation and ultrasound were performed to measure follicular growth and detect ovulation. Blood samples were drawn on 3 d and 6 d post-ovulation to analyze plasma progesterone (P4) levels. One-way ANOVA and Tukey Method Pairwise Comparisons were used for data analysis. Between treatments on 3 d and 6 d post-ovulation, plasma P4 values were not statistically different. Mean intervals from ovulation to ovulation for treatments 1, 2, and 3 were 14.8 d ± 3.1, 12.9 d ± 6.3 d and 14.3 d ± 1.4 respectively. Mean intervals from first day of treatment to ovulation were 9.8 d ± 2.0, 12.9 d ± 6.3, and 12.6 d ±1.7. Results did not show significant statistical difference. Further research is needed on low-dose administration of PGF2α. Advisors/Committee Members: Gary Webb.

Subjects/Keywords: mare; prostaglandin; synchronization; estrous; lutalyse; Agriculture

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Potter, K. M. (2017). Comparison of Serial PGF2α Protocols for Control of the Estrous Cycle in Mares. (Masters Thesis). Missouri State University. Retrieved from https://bearworks.missouristate.edu/theses/3155

Chicago Manual of Style (16th Edition):

Potter, Kaleigh Marie. “Comparison of Serial PGF2α Protocols for Control of the Estrous Cycle in Mares.” 2017. Masters Thesis, Missouri State University. Accessed April 14, 2021. https://bearworks.missouristate.edu/theses/3155.

MLA Handbook (7th Edition):

Potter, Kaleigh Marie. “Comparison of Serial PGF2α Protocols for Control of the Estrous Cycle in Mares.” 2017. Web. 14 Apr 2021.

Vancouver:

Potter KM. Comparison of Serial PGF2α Protocols for Control of the Estrous Cycle in Mares. [Internet] [Masters thesis]. Missouri State University; 2017. [cited 2021 Apr 14]. Available from: https://bearworks.missouristate.edu/theses/3155.

Council of Science Editors:

Potter KM. Comparison of Serial PGF2α Protocols for Control of the Estrous Cycle in Mares. [Masters Thesis]. Missouri State University; 2017. Available from: https://bearworks.missouristate.edu/theses/3155


Virginia Tech

2. Wulster-Radcliffe, Meghan Carole. The Mechanism of Action of Exogenous PGF2alpha in Clearance of Nonspecific Uterine Infections in Sheep and Pigs.

Degree: PhD, Animal and Poultry Sciences, 2000, Virginia Tech

Six experiments were conducted to determine the mechanism of action of exogenous PGF2alpha on the clearance of uterine infections in sheep and pigs. The first two experiments were designed to characterize the uterine immune response to bacterial infection under progesterone dominance in pigs. The uterine immune response to infections seems to change with parity. This is probably an artifact of increased number of bacterial exposures; therefore, the third experiment was designed to evaluate the uterine immune response to multiple intrauterine bacterial inoculations. Experiments 4, 5, and 6 were designed to evaluate the effects of endogenous and exogenous PGF2alpha on the uterine immune response to uterine infections in sheep and pigs. Injections with Lutalyse (PGF2alpha analogue) during the luteal phase in sheep causes luteolysis; therefore, it impossible to evaluate the effects of Lutalyse independently of luteolysis. In order to cause an endogenous release of PGF2alpha without causing luteolysis in sheep a PGF2alpha secretagogue (oxytocin) was used in Exp. 5. And in Exp. 6, we were able to evaluate the effects of Lutalyse independently of luteolysis using pigs as a model. From these six experiments we concluded that during periods of estrogen dominance, the uterine immune system is up-regulated, and therefore, infections do not develop after intrauterine inoculation with bacteria, during periods of progesterone dominance, the uterine immune system is down-regulated, and, therefore, infections develop after intrauterine inoculation with bacteria, and stimulation of the uterus with PGF2alpha or oxytocin independently of luteolysis up-regulates the uterine immune. Advisors/Committee Members: Eng, Ludeman A. (committee member), Elgert, Klaus D. (committee member), McGilliard, Michael L. (committee member), Saacke, Richard G. (committeecochair), Lewis, Gregory S. (committeecochair).

Subjects/Keywords: Lutalyse; pigs; uterine infections; sheep

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Wulster-Radcliffe, M. C. (2000). The Mechanism of Action of Exogenous PGF2alpha in Clearance of Nonspecific Uterine Infections in Sheep and Pigs. (Doctoral Dissertation). Virginia Tech. Retrieved from http://hdl.handle.net/10919/37670

Chicago Manual of Style (16th Edition):

Wulster-Radcliffe, Meghan Carole. “The Mechanism of Action of Exogenous PGF2alpha in Clearance of Nonspecific Uterine Infections in Sheep and Pigs.” 2000. Doctoral Dissertation, Virginia Tech. Accessed April 14, 2021. http://hdl.handle.net/10919/37670.

MLA Handbook (7th Edition):

Wulster-Radcliffe, Meghan Carole. “The Mechanism of Action of Exogenous PGF2alpha in Clearance of Nonspecific Uterine Infections in Sheep and Pigs.” 2000. Web. 14 Apr 2021.

Vancouver:

Wulster-Radcliffe MC. The Mechanism of Action of Exogenous PGF2alpha in Clearance of Nonspecific Uterine Infections in Sheep and Pigs. [Internet] [Doctoral dissertation]. Virginia Tech; 2000. [cited 2021 Apr 14]. Available from: http://hdl.handle.net/10919/37670.

Council of Science Editors:

Wulster-Radcliffe MC. The Mechanism of Action of Exogenous PGF2alpha in Clearance of Nonspecific Uterine Infections in Sheep and Pigs. [Doctoral Dissertation]. Virginia Tech; 2000. Available from: http://hdl.handle.net/10919/37670

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