subject:(Lung)

Oklahoma State University

1. Wang, Yang. Functions of Micrornas in Lung Injury and Development.

Degree: Veterinary Pathobiology, 2011, Oklahoma State University

► The purpose of this study is to figure out what are the functions of microRNAs in lung development and injury. First, a microRNA microarray was… (more)

Subjects/Keywords: lung; microrna

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Wang, Y. (2011). Functions of Micrornas in Lung Injury and Development. (Thesis). Oklahoma State University. Retrieved from http://hdl.handle.net/11244/7677

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Wang, Yang. “Functions of Micrornas in Lung Injury and Development.” 2011. Thesis, Oklahoma State University. Accessed February 23, 2020. http://hdl.handle.net/11244/7677.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Wang, Yang. “Functions of Micrornas in Lung Injury and Development.” 2011. Web. 23 Feb 2020.

Vancouver:

Wang Y. Functions of Micrornas in Lung Injury and Development. [Internet] [Thesis]. Oklahoma State University; 2011. [cited 2020 Feb 23]. Available from: http://hdl.handle.net/11244/7677.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Wang Y. Functions of Micrornas in Lung Injury and Development. [Thesis]. Oklahoma State University; 2011. Available from: http://hdl.handle.net/11244/7677

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universidad de Cantabria

2. Duerto Álvarez, Jorge. Efecto a largo plazo en los injertos renales de un protocolo de manejo intensivo del donante multiorgánico.

Degree: 2016, Universidad de Cantabria

URL: http://hdl.handle.net/10902/9627

► La escasez de órganos disponibles para trasplante es la principal limitación en el desarrollo de esta terapia. Esto es especialmente acusado en el trasplante pulmonar,… (more)

Subjects/Keywords: Lung donor

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Duerto Álvarez, J. (2016). Efecto a largo plazo en los injertos renales de un protocolo de manejo intensivo del donante multiorgánico. (Doctoral Dissertation). Universidad de Cantabria. Retrieved from http://hdl.handle.net/10902/9627

Chicago Manual of Style (16^th Edition):

Duerto Álvarez, Jorge. “Efecto a largo plazo en los injertos renales de un protocolo de manejo intensivo del donante multiorgánico.” 2016. Doctoral Dissertation, Universidad de Cantabria. Accessed February 23, 2020. http://hdl.handle.net/10902/9627.

MLA Handbook (7^th Edition):

Duerto Álvarez, Jorge. “Efecto a largo plazo en los injertos renales de un protocolo de manejo intensivo del donante multiorgánico.” 2016. Web. 23 Feb 2020.

Vancouver:

Duerto Álvarez J. Efecto a largo plazo en los injertos renales de un protocolo de manejo intensivo del donante multiorgánico. [Internet] [Doctoral dissertation]. Universidad de Cantabria; 2016. [cited 2020 Feb 23]. Available from: http://hdl.handle.net/10902/9627.

Council of Science Editors:

Duerto Álvarez J. Efecto a largo plazo en los injertos renales de un protocolo de manejo intensivo del donante multiorgánico. [Doctoral Dissertation]. Universidad de Cantabria; 2016. Available from: http://hdl.handle.net/10902/9627

University of Southern California

3. Selamat, Suhaida Adura. DNA methylation changes in the development of lung adenocarcinoma.

Degree: PhD, Genetic, Molecular and Cellular Biology, 2012, University of Southern California

URL: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/2645/rec/2066

► Lung cancer accounted for 13% of total cancer cases and 18% of cancer deaths globally in 2008. The combination of increasing smoking prevalence in many… (more)

Subjects/Keywords: DNA methylation; lung adenocarcinoma; lung cancer; epigenetics

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Selamat, S. A. (2012). DNA methylation changes in the development of lung adenocarcinoma. (Doctoral Dissertation). University of Southern California. Retrieved from http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/2645/rec/2066

Chicago Manual of Style (16^th Edition):

Selamat, Suhaida Adura. “DNA methylation changes in the development of lung adenocarcinoma.” 2012. Doctoral Dissertation, University of Southern California. Accessed February 23, 2020. http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/2645/rec/2066.

MLA Handbook (7^th Edition):

Selamat, Suhaida Adura. “DNA methylation changes in the development of lung adenocarcinoma.” 2012. Web. 23 Feb 2020.

Vancouver:

Selamat SA. DNA methylation changes in the development of lung adenocarcinoma. [Internet] [Doctoral dissertation]. University of Southern California; 2012. [cited 2020 Feb 23]. Available from: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/2645/rec/2066.

Council of Science Editors:

Selamat SA. DNA methylation changes in the development of lung adenocarcinoma. [Doctoral Dissertation]. University of Southern California; 2012. Available from: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/2645/rec/2066

4. Sinzala, Martha. Prevalence and factors associated with acute occupational lung disease among Cotton Ginnery workers in Katete District.

Degree: 2014, University of Zimbabwe

URL: http://dspace.unza.zm/handle/123456789/3206

► The presence of byssinosis among workers in cotton ginneries has been well documented in studies from several countries.However, no studies had been performed among cotton… (more)

▼ The presence of byssinosis among workers in cotton ginneries has been well documented in studies from several countries.However, no studies had been performed among cotton workers in the Eastern Province of Zambia. In view of this, a cross sectional study design with 151 sample elements, drawn from Dunavant Ginnery in Katete, was employed. The main purpose of the study was to find out the prevalence of byssinosis among cotton ginnery workers. A survey questionnaire and lung function tests were conducted by a trained technician using a spirobank G spirometer. At the time of the study, the workers were employed in five departments and just about half n= 77 (51.1%) were involved in carding with 48.1% involved in other jobs. The longest a worker had served the company was 180 months or fifteen years and the least was barely one month.Out of the 151 workers, only 50 workers (33.1%) did not experience any symptoms of byssinosis. A greater number suffered from chest tightness and/or shortness of breath on most of first days back at work and on the first and other days of the working week. However, 76 (50.6%) of the workers showed a reduction in one symptom over the weekends and an increase in another within the week. Using the generally accepted World Health Organisation (WHO) (1983) criteria, this study found evidence for byssinosis among cotton workers with the highest prevalence of among those who at the time of the study had been engaged in carding, blending, and cleaning processes. The prevalence of byssinosis among cotton workers was 67%. Lung functional tests showed a peculiar trend of decline from day one today four in this sample under study. Of the four lung function tests, Forced Expiratory Volume per second (FEVs) and Forced Vital Capacity (FVC) showed more consistent reduction changes. However, all lung function tests were not significantly associated with work induced byssinotic symptoms. It can, therefore, be concluded on the basis of the study that byssinosis occurs in cotton workers particularly in those who are exposed to high concentrations of dust for a longer period especially in unmanaged and unprotected working environments. The study recommends the provision of protective clothing, environmental hygiene and periodic medical examination at two yearly intervals to identify those who ultimately will have to leave the industry because of progressive symptoms.

Subjects/Keywords: Lung Disease; Respiratory Distress; Lung Diseases

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Sinzala, M. (2014). Prevalence and factors associated with acute occupational lung disease among Cotton Ginnery workers in Katete District. (Thesis). University of Zimbabwe. Retrieved from http://dspace.unza.zm/handle/123456789/3206

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Sinzala, Martha. “Prevalence and factors associated with acute occupational lung disease among Cotton Ginnery workers in Katete District.” 2014. Thesis, University of Zimbabwe. Accessed February 23, 2020. http://dspace.unza.zm/handle/123456789/3206.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Sinzala, Martha. “Prevalence and factors associated with acute occupational lung disease among Cotton Ginnery workers in Katete District.” 2014. Web. 23 Feb 2020.

Vancouver:

Sinzala M. Prevalence and factors associated with acute occupational lung disease among Cotton Ginnery workers in Katete District. [Internet] [Thesis]. University of Zimbabwe; 2014. [cited 2020 Feb 23]. Available from: http://dspace.unza.zm/handle/123456789/3206.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Sinzala M. Prevalence and factors associated with acute occupational lung disease among Cotton Ginnery workers in Katete District. [Thesis]. University of Zimbabwe; 2014. Available from: http://dspace.unza.zm/handle/123456789/3206

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

5. Wang, Zihao. Conceptualization and design of a future chest drainage canister.

Degree: Umeå Institute of Design, 2016, Umeå University

URL: http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-125683

► Changsha city in Hunan province, China. Place: Changsha Center Hospital, Hunan province. City Area: 11,819 square kilometers City population: 714.66 million I watched the… (more)

Subjects/Keywords: Damaged lung; chest drainage system; collapsed lung

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Wang, Z. (2016). Conceptualization and design of a future chest drainage canister. (Thesis). Umeå University. Retrieved from http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-125683

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Wang, Zihao. “Conceptualization and design of a future chest drainage canister.” 2016. Thesis, Umeå University. Accessed February 23, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-125683.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Wang, Zihao. “Conceptualization and design of a future chest drainage canister.” 2016. Web. 23 Feb 2020.

Vancouver:

Wang Z. Conceptualization and design of a future chest drainage canister. [Internet] [Thesis]. Umeå University; 2016. [cited 2020 Feb 23]. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-125683.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Wang Z. Conceptualization and design of a future chest drainage canister. [Thesis]. Umeå University; 2016. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-125683

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Temple University

6. Stabler, Collin Turner. Optimizing Endothelial Repopulation of Decellularized Lung.

Degree: PhD, 2016, Temple University

URL: http://digital.library.temple.edu/u?/p245801coll10,388434

►

Bioengineering

Decellularized lung tissue has been recognized as a potential platform to engineer whole lung organs suitable for transplantation or for modeling a variety of… (more)

▼

Bioengineering

Decellularized lung tissue has been recognized as a potential platform to engineer whole lung organs suitable for transplantation or for modeling a variety of lung diseases. However many technical hurdles remain before this potential may be fully realized. Inability to efficiently re-endothelialize the pulmonary vasculature with a functional endothelium appears to be the primary cause of failure of recellularized lung scaffolds in early transplant studies. This dissertation research aims to enhance the re-endothelialization of decellularized rodent lung scaffolds with rat lung microvascular endothelial cells. This was achieved by adjusting the posture of the lung to a supine position during cell seeding through the pulmonary artery. The supine position allowed for significantly more homogeneous seeding and better cell retention in the apex regions of all lobes than the traditional upright position, especially in the right upper and left lobes. Additionally, the supine position allowed for greater cell retention within large diameter vessels (proximal – 100 µm to 5,000 µm) than the upright position, with little to no difference in the small diameter distal vessels. Endothelial cell adhesion in the proximal regions of the pulmonary vasculature in the decellularized lung was dependent on the binding of endothelial cell integrins, specifically α1β1, α2β1 and α5β1 integrins to, respectively, collagen type-I, type-IV and fibronectin in the residual ECM. Following in vitro maturation of the seeded constructs under perfusion culture, the seeded endothelial cells spread along the vascular wall, leading to a partial re-establishment of endothelial barrier function as inferred from a custom-designed leakage assay. The results of this dissertation research suggest that attention to cellular distribution within the whole organ is of paramount importance for restoring proper vascular function.

Temple University – Theses

Advisors/Committee Members: Lelkes, Peter I.;, Pleshko, Nancy, Marcinkiewicz, Cezary, Wolfson, Marla R., Schulman, Edward S.;.

Subjects/Keywords: Biomedical engineering;

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Stabler, C. T. (2016). Optimizing Endothelial Repopulation of Decellularized Lung. (Doctoral Dissertation). Temple University. Retrieved from http://digital.library.temple.edu/u?/p245801coll10,388434

Chicago Manual of Style (16^th Edition):

Stabler, Collin Turner. “Optimizing Endothelial Repopulation of Decellularized Lung.” 2016. Doctoral Dissertation, Temple University. Accessed February 23, 2020. http://digital.library.temple.edu/u?/p245801coll10,388434.

MLA Handbook (7^th Edition):

Stabler, Collin Turner. “Optimizing Endothelial Repopulation of Decellularized Lung.” 2016. Web. 23 Feb 2020.

Vancouver:

Stabler CT. Optimizing Endothelial Repopulation of Decellularized Lung. [Internet] [Doctoral dissertation]. Temple University; 2016. [cited 2020 Feb 23]. Available from: http://digital.library.temple.edu/u?/p245801coll10,388434.

Council of Science Editors:

Stabler CT. Optimizing Endothelial Repopulation of Decellularized Lung. [Doctoral Dissertation]. Temple University; 2016. Available from: http://digital.library.temple.edu/u?/p245801coll10,388434

Harvard University

7. Li, Richard. Venous Thromboembolism Risk in Patients With Locally Advanced Non-Small Cell Lung Cancer.

Degree: Doctor of Medicine, 2016, Harvard University

URL: http://nrs.harvard.edu/urn-3:HUL.InstRepos:40620276

►

Background: Patients with non-small cell lung cancer (NSCLC) are known to be at high risk for venous thromboembolism (VTE), but previous studies have not specifically… (more)

Subjects/Keywords: lung cancer; thromboembolism

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Li, R. (2016). Venous Thromboembolism Risk in Patients With Locally Advanced Non-Small Cell Lung Cancer. (Doctoral Dissertation). Harvard University. Retrieved from http://nrs.harvard.edu/urn-3:HUL.InstRepos:40620276

Chicago Manual of Style (16^th Edition):

Li, Richard. “Venous Thromboembolism Risk in Patients With Locally Advanced Non-Small Cell Lung Cancer.” 2016. Doctoral Dissertation, Harvard University. Accessed February 23, 2020. http://nrs.harvard.edu/urn-3:HUL.InstRepos:40620276.

MLA Handbook (7^th Edition):

Li, Richard. “Venous Thromboembolism Risk in Patients With Locally Advanced Non-Small Cell Lung Cancer.” 2016. Web. 23 Feb 2020.

Vancouver:

Li R. Venous Thromboembolism Risk in Patients With Locally Advanced Non-Small Cell Lung Cancer. [Internet] [Doctoral dissertation]. Harvard University; 2016. [cited 2020 Feb 23]. Available from: http://nrs.harvard.edu/urn-3:HUL.InstRepos:40620276.

Council of Science Editors:

Li R. Venous Thromboembolism Risk in Patients With Locally Advanced Non-Small Cell Lung Cancer. [Doctoral Dissertation]. Harvard University; 2016. Available from: http://nrs.harvard.edu/urn-3:HUL.InstRepos:40620276

University of Dundee

8. Robertson, Holly. Mechanisms of repression of the transcription factor NRF2 by KEAP1- and B-TrCP-dependent ubiquitin ligases and how the dysregulation of NRF2 contributes to lung cancer progression.

Degree: PhD, 2019, University of Dundee

URL: https://discovery.dundee.ac.uk/en/studentTheses/4a7f87db-89f1-4bc4-b273-1bd7eb72ab0e ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.775364

► Lung cancer is the leading cause of cancer related mortality worldwide and since the discovery of the important role that NRF2 plays in regulating the… (more)

▼ Lung cancer is the leading cause of cancer related mortality worldwide and since the discovery of the important role that NRF2 plays in regulating the expression of phase II drug metabolism genes, NRF2 has been a highly studied therapeutic target. NRF2 signalling is often elevated in lung cancer due to mutations in NFE2L2, the gene that encodes NRF2; and KEAP1, the cytoplasmic regulator of NRF2. Since it became established that elevated NRF2 signalling provides a beneficial role to the tumour through enhancing proliferation, enabling survival in highly oxidative conditions and enhancing resistance to chemotherapeutic drugs; many groups have focussed on understanding KEAP1-independent forms of NRF2 regulation. It is now widely accepted that GSK-3 phosphorylation of the Neh6 domain of NRF2 is fundamental for SCFβ-TrCP-mediated degradation of the transcription factor. Previous work by other groups has indicated a potential role for a priming kinase to pre-phosphorylate the Neh6 domain and subsequently enhance GSK-3 mediated phosphorylation and resulting 26S proteasomal degradation. In the first results chapter of this thesis it was demonstrated using the DYRK family of isoenzymes that the presence of a priming kinase enhances GSK-3 phosphorylation and stimulates NRF2 degradation. Also, it has been shown that DYRK family members carry out priming of NRF2 through phosphorylating Ser-347, which enhances subsequent phosphorylation of Ser-342 and Ser-338 by GSK-3; regulating both NRF2 activity and stability. Additionally, it was shown that altering the phosphorylation status of Ser-347 impacts cell proliferation and chemo-sensitivity to platinum-based compounds. The ability of other kinases to phosphorylate the Neh6 domain was also revealed. In the second results chapter of this thesis a bioinformatics style approach was utilized to analyse the impact of mutations in KEAP1, NFE2L2 and CUL3; in terms of their effect on NRF2 activity using the expression of NRF2-target genes as a read out. The following points were highlighted from this analysis; (1) KEAP1 mutations are more prevalent than NFE2L2 and CUL3 mutations in both lung cancer cell lines and tumours; (2) KEAP1 and NFE2L2 mutations vary in there associated zygosity's, with KEAP1 mutations being predominantly homozygous and NFE2L2 mutations being predominantly heterozygous; (3) mutations in KEAP1 coexist with mutations in KRAS whereas, mutations in NFE2L2 co-exist with mutations in TP53 and (4) lung cancer cell lines and tumours harbouring mutations in KEAP1 have greater expression of NRF2-target genes than those harbouring either NFE2L2 or CUL3 mutations. In the third and final results chapter, both a panel of commercial cell lines and an in-house generated CRISPR/Cas9 panel of cell lines have been shown in multiple experiments to validate the bioinformatics findings of the previous chapter. Also, in this chapter it was identified that KEAP1 mutant cells are more reliant on the glutathione biosynthesis pathway for survival and therefore more sensitive to alterations in…

Subjects/Keywords: NRF2; Lung Cancer

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Robertson, H. (2019). Mechanisms of repression of the transcription factor NRF2 by KEAP1- and B-TrCP-dependent ubiquitin ligases and how the dysregulation of NRF2 contributes to lung cancer progression. (Doctoral Dissertation). University of Dundee. Retrieved from https://discovery.dundee.ac.uk/en/studentTheses/4a7f87db-89f1-4bc4-b273-1bd7eb72ab0e ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.775364

Chicago Manual of Style (16^th Edition):

Robertson, Holly. “Mechanisms of repression of the transcription factor NRF2 by KEAP1- and B-TrCP-dependent ubiquitin ligases and how the dysregulation of NRF2 contributes to lung cancer progression.” 2019. Doctoral Dissertation, University of Dundee. Accessed February 23, 2020. https://discovery.dundee.ac.uk/en/studentTheses/4a7f87db-89f1-4bc4-b273-1bd7eb72ab0e ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.775364.

MLA Handbook (7^th Edition):

Robertson, Holly. “Mechanisms of repression of the transcription factor NRF2 by KEAP1- and B-TrCP-dependent ubiquitin ligases and how the dysregulation of NRF2 contributes to lung cancer progression.” 2019. Web. 23 Feb 2020.

Vancouver:

Robertson H. Mechanisms of repression of the transcription factor NRF2 by KEAP1- and B-TrCP-dependent ubiquitin ligases and how the dysregulation of NRF2 contributes to lung cancer progression. [Internet] [Doctoral dissertation]. University of Dundee; 2019. [cited 2020 Feb 23]. Available from: https://discovery.dundee.ac.uk/en/studentTheses/4a7f87db-89f1-4bc4-b273-1bd7eb72ab0e ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.775364.

Council of Science Editors:

Robertson H. Mechanisms of repression of the transcription factor NRF2 by KEAP1- and B-TrCP-dependent ubiquitin ligases and how the dysregulation of NRF2 contributes to lung cancer progression. [Doctoral Dissertation]. University of Dundee; 2019. Available from: https://discovery.dundee.ac.uk/en/studentTheses/4a7f87db-89f1-4bc4-b273-1bd7eb72ab0e ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.775364

University of New South Wales

9. Wong, Sze Wing (Alice). Functions of S100A8 in lung cancer.

Degree: Medical Sciences, 2018, University of New South Wales

URL: http://handle.unsw.edu.au/1959.4/60230

► S100A8 is an anti-inflammatory oxidant scavenger protein that induces IL-10 in airway epithelial cells in normal lungs following inhalation. These mechanisms contribute to its ability… (more)

Subjects/Keywords: Lung cancer; S100A8

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Wong, S. W. (. (2018). Functions of S100A8 in lung cancer. (Doctoral Dissertation). University of New South Wales. Retrieved from http://handle.unsw.edu.au/1959.4/60230

Chicago Manual of Style (16^th Edition):

Wong, Sze Wing (Alice). “Functions of S100A8 in lung cancer.” 2018. Doctoral Dissertation, University of New South Wales. Accessed February 23, 2020. http://handle.unsw.edu.au/1959.4/60230.

MLA Handbook (7^th Edition):

Wong, Sze Wing (Alice). “Functions of S100A8 in lung cancer.” 2018. Web. 23 Feb 2020.

Vancouver:

Wong SW(. Functions of S100A8 in lung cancer. [Internet] [Doctoral dissertation]. University of New South Wales; 2018. [cited 2020 Feb 23]. Available from: http://handle.unsw.edu.au/1959.4/60230.

Council of Science Editors:

Wong SW(. Functions of S100A8 in lung cancer. [Doctoral Dissertation]. University of New South Wales; 2018. Available from: http://handle.unsw.edu.au/1959.4/60230

Dalhousie University

10. Leary, Del. MODELING OF SPATIAL AND TEMPORAL HETEROGENEITY OF THE HUMAN LUNG.

Degree: PhD, Department of Physics & Atmospheric Science, 2013, Dalhousie University

URL: http://hdl.handle.net/10222/36311

► This thesis investigates variability in airway caliber and the distribution of ventilation within the human lung as thought to occur in asthma. Currently, the understanding… (more)

▼ This thesis investigates variability in airway caliber and the distribution of ventilation within the human lung as thought to occur in asthma. Currently, the understanding of how an integrated network of airways can lead to temporal and spatial variation as found in the human lung is unclear. Throughout this thesis, a multibranch airway tree model was used in a forward modeling approach. In a variability study, the mean airway resistance (RL) was observed to be proportional to the standard deviation in airway resistance (SDRL) as reported in the literature under several conditions of airway diameter indicating the strong robustness of this behavior. The model predicted previously reported RL distributions and the reported proportionality of SDRL and RL, but only when we included coherency between airways. In a second study, patient specific ventilation was investigated using an image functional approach by closing specific airways (creating defects) identified by hyperpolarized 3He MRI from asthmatic subjects. Impedance predictions from the imposed heterogeneous ventilation were then calculated and correlated to 3He MRI ventilation defect percent (VDP), plethysmography, and spirometry data. These predictions suggest the forced oscillation technique (FOT) to be a superior metric toward the evaluation of the VDP. In a third study, we investigated how asymmetric branching could play a role in ventilation defect emergence and persistence. At high muscle activation levels simulating an asthmatic episode, airway trees with greater asymmetry reached steady state sooner, with defects that were more persistent in location, had lower RL values (~50%), and greater EL values (~25%) after bronchoconstriction. These results suggest the initial formation of ventilation defects was dependent on airway instability; however, the location and persistence of ventilation defects may be due to geometric airway structure. By modeling the contribution of ventilation defects to lung impedance, we were able to show that defects can play a role in governing the relationship between RL and its variation, and the effect of defects through VDP could be better assessed using FOT. Moreover, lung structure contributed to the emergence and persistence of ventilation defects, meaning that defects could be potentially ameliorated through structural intervention. Advisors/Committee Members: Jason Bates (external-examiner), Jordan Kyriakidis (graduate-coordinator), Steven Beyea, Grace Parraga, Andrew Rutenberg (thesis-reader), Geoff Maksym (thesis-supervisor), Not Applicable (ethics-approval), Yes (manuscripts), Yes (copyright-release).

Subjects/Keywords: lung modeling; temporal variability; spatial variability; human lung; lung mechanics

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Leary, D. (2013). MODELING OF SPATIAL AND TEMPORAL HETEROGENEITY OF THE HUMAN LUNG. (Doctoral Dissertation). Dalhousie University. Retrieved from http://hdl.handle.net/10222/36311

Chicago Manual of Style (16^th Edition):

Leary, Del. “MODELING OF SPATIAL AND TEMPORAL HETEROGENEITY OF THE HUMAN LUNG.” 2013. Doctoral Dissertation, Dalhousie University. Accessed February 23, 2020. http://hdl.handle.net/10222/36311.

MLA Handbook (7^th Edition):

Leary, Del. “MODELING OF SPATIAL AND TEMPORAL HETEROGENEITY OF THE HUMAN LUNG.” 2013. Web. 23 Feb 2020.

Vancouver:

Leary D. MODELING OF SPATIAL AND TEMPORAL HETEROGENEITY OF THE HUMAN LUNG. [Internet] [Doctoral dissertation]. Dalhousie University; 2013. [cited 2020 Feb 23]. Available from: http://hdl.handle.net/10222/36311.

Council of Science Editors:

Leary D. MODELING OF SPATIAL AND TEMPORAL HETEROGENEITY OF THE HUMAN LUNG. [Doctoral Dissertation]. Dalhousie University; 2013. Available from: http://hdl.handle.net/10222/36311

University of Toronto

11. Reck dos Santos, Pedro Augusto. Development of In Vivo Lung Perfusion Strategy for the Treatment of Lung Metastases.

Degree: 2015, University of Toronto

URL: http://hdl.handle.net/1807/69694

►

In Vivo Lung Perfusion (IVLP) can potentially enhance the treatment of lung metastases by allowing the delivery of elevated doses of chemotherapy to the lungs… (more)

Subjects/Keywords: In Vivo Lung Perfusion; Isolated Lung Perfusion; Locoregional Therapy; Lung Metastases; Pulmonary Metastasectomy; Sarcomas; 0576

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Reck dos Santos, P. A. (2015). Development of In Vivo Lung Perfusion Strategy for the Treatment of Lung Metastases. (Masters Thesis). University of Toronto. Retrieved from http://hdl.handle.net/1807/69694

Chicago Manual of Style (16^th Edition):

Reck dos Santos, Pedro Augusto. “Development of In Vivo Lung Perfusion Strategy for the Treatment of Lung Metastases.” 2015. Masters Thesis, University of Toronto. Accessed February 23, 2020. http://hdl.handle.net/1807/69694.

MLA Handbook (7^th Edition):

Reck dos Santos, Pedro Augusto. “Development of In Vivo Lung Perfusion Strategy for the Treatment of Lung Metastases.” 2015. Web. 23 Feb 2020.

Vancouver:

Reck dos Santos PA. Development of In Vivo Lung Perfusion Strategy for the Treatment of Lung Metastases. [Internet] [Masters thesis]. University of Toronto; 2015. [cited 2020 Feb 23]. Available from: http://hdl.handle.net/1807/69694.

Council of Science Editors:

Reck dos Santos PA. Development of In Vivo Lung Perfusion Strategy for the Treatment of Lung Metastases. [Masters Thesis]. University of Toronto; 2015. Available from: http://hdl.handle.net/1807/69694

University of Gothenburg / Göteborgs Universitet

12. Wallinder, Andreas. Ex Vivo Lung Perfusion - clinical and experimental studies.

Degree: 2014, University of Gothenburg / Göteborgs Universitet

URL: http://hdl.handle.net/2077/35943

► For patients who are suffering from end-stage lung disease, lung transplantation is a life-prolonging therapy. The number of donor lungs is limited and the majority… (more)

▼ For patients who are suffering from end-stage lung disease, lung transplantation is a life-prolonging therapy. The number of donor lungs is limited and the majority of available donor lungs, in some regions up to 85%, are discarded due to known or presumed organ dysfunction. Lung donations after cardiac death (DCD) and increased utilization of lungs from donations after brain death (DBD) could increase the availability of donor organs. Ex vivo lung perfusion (EVLP) is a method that has been developed for the preservation and evaluation of donor lungs during continuous perfusion and ventilation. EVLP is applicable to lungs harvested from DCD, as well as to the lungs of DBD with suboptimal lung function. Method: In Papers I and II, an uncontrolled DCD situation was simulated in a pig model. The currently suggested protocol for DCD lung procurement, involving post-mortem administration of heparin followed by chest compressions and intrapleural cooling of the lungs to 12°C, was compared to a simplified procurement method that does not use heparin and employs a less-invasive cooling technique. In Papers III–V, the methods and results for EVLP for the salvage of initially rejected human donor lungs were investigated. Rejected donor lungs with inferior function were retrieved and connected to the EVLP system. Assessments of lung function, with respect to circulatory and respiratory parameters, were performed. EVLP-treated lungs that were deemed to have normal function were transplanted into recipients from the conventional waiting list for transplantation. The short-term and long-term outcomes for the recipients of the EVLP-treated lungs were compared to a consecutive series of patients who received non- EVLP lungs prepared according to the standard protocol. Results: In Papers I and II, the lung function assessed during EVLP and at post-EVLP analyses in terms of the water content of lung tissues and markers of lung injury, did not differ significantly between the treatment and control groups. In Papers III–V, 25 pairs of rejected donor lungs underwent EVLP. Eighteen double lungs and four single lungs were transplanted after EVLP, and the recipients (EVLP group; N=22) were compared with recipients of conventionally prepared lungs (Control group; N=115). The median time to extubation (p=0.26) and the median stay in the intensive care unit (p=0.06) did not differ significantly for the two groups. Primary graft dysfunction higher than grade 1 was noted for 14% of the recipients in the EVLP group and 11% of the Control group at 72 hours post-transplantation. The cumulative 1-year survival rates were 89% for the EVLP group and 82% for the Control group. The cumulative survival rates for up to three years of follow-up were comparable for these two groups (p=0.67). Conclusion: Papers I and II provide support for the notion that a no-touch period of 1 hour after death in cases of uncontrolled DCD would not compromise donor lung function. This would allow the next-of-kin to spend time with the deceased and to facilitate the…

Subjects/Keywords: Lung transplantation; Ex vivo lung perfusion; Donation after cardiac death; Donor lung procurement

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Wallinder, A. (2014). Ex Vivo Lung Perfusion - clinical and experimental studies. (Thesis). University of Gothenburg / Göteborgs Universitet. Retrieved from http://hdl.handle.net/2077/35943

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Wallinder, Andreas. “Ex Vivo Lung Perfusion - clinical and experimental studies.” 2014. Thesis, University of Gothenburg / Göteborgs Universitet. Accessed February 23, 2020. http://hdl.handle.net/2077/35943.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Wallinder, Andreas. “Ex Vivo Lung Perfusion - clinical and experimental studies.” 2014. Web. 23 Feb 2020.

Vancouver:

Wallinder A. Ex Vivo Lung Perfusion - clinical and experimental studies. [Internet] [Thesis]. University of Gothenburg / Göteborgs Universitet; 2014. [cited 2020 Feb 23]. Available from: http://hdl.handle.net/2077/35943.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Wallinder A. Ex Vivo Lung Perfusion - clinical and experimental studies. [Thesis]. University of Gothenburg / Göteborgs Universitet; 2014. Available from: http://hdl.handle.net/2077/35943

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Dundee

13. Buchanan, Deans. The clinical care of patients with lung cancer : identifying and supporting those with unmet care needs.

Degree: Thesis (M.D.), 2010, University of Dundee

URL: http://hdl.handle.net/10588/43cf70da-fac1-41d5-be95-213521128c52

► Lung cancer has developed from a rare condition into the leading cause of cancerrelated death in the United Kingdom. Lung cancer patients face a disease… (more)

▼ Lung cancer has developed from a rare condition into the leading cause of cancerrelated death in the United Kingdom. Lung cancer patients face a disease with a high symptom burden, increased psychosocial needs and a high mortality. Supportive care needs are often relevant from diagnosis. Despite this there are no clear follow-up structures for lung cancer patients that address both cancer management and supportive care. The aims of this study were to evaluate supportive care needs, assess predictors of such needs and identify factors which could aid service provision within Stobhill lung cancer services. Methods Supportive care needs were measured using an adapted Palliative Outcome Scale (POS), incorporated within a larger questionnaire. All lung cancer patients attending the clinic could complete this questionnaire. Respiratory symptoms, performance status, service usage, preferences and satisfaction were also assessed. Data were stratified to allow evaluation of three clinical groupings: all patients, newly diagnosed patients and patients in the last three months of life. Analyses were phased: descriptive analyses, univariate tests of association and multivariate regression. Results Three hundred and fifty three lung cancer patients completed questionnaires. The high symptom burden in lung cancer was confirmed. Anxiety, pain and dyspnoea were identified as the key issues. Poor performance status was identified to be an independent predictor of increased POS score, increased anxiety, increased pain and increased dyspnoea. There was no independent relationship between POS and survival. Although the majority of patients were satisfied with the care received, there was uncertainty regarding who was in charge of care and some disparity in preferred structure for follow-up. Conclusions Despite recent advances in lung cancer management, improvements are still required to address unmet supportive care needs of patients. Particular attention should be given to those with poorer performance status to effectively identify and meet such needs.

Subjects/Keywords: Lung cancer; Supportive care; Symptoms

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Buchanan, D. (2010). The clinical care of patients with lung cancer : identifying and supporting those with unmet care needs. (Doctoral Dissertation). University of Dundee. Retrieved from http://hdl.handle.net/10588/43cf70da-fac1-41d5-be95-213521128c52

Chicago Manual of Style (16^th Edition):

Buchanan, Deans. “The clinical care of patients with lung cancer : identifying and supporting those with unmet care needs.” 2010. Doctoral Dissertation, University of Dundee. Accessed February 23, 2020. http://hdl.handle.net/10588/43cf70da-fac1-41d5-be95-213521128c52.

MLA Handbook (7^th Edition):

Buchanan, Deans. “The clinical care of patients with lung cancer : identifying and supporting those with unmet care needs.” 2010. Web. 23 Feb 2020.

Vancouver:

Buchanan D. The clinical care of patients with lung cancer : identifying and supporting those with unmet care needs. [Internet] [Doctoral dissertation]. University of Dundee; 2010. [cited 2020 Feb 23]. Available from: http://hdl.handle.net/10588/43cf70da-fac1-41d5-be95-213521128c52.

Council of Science Editors:

Buchanan D. The clinical care of patients with lung cancer : identifying and supporting those with unmet care needs. [Doctoral Dissertation]. University of Dundee; 2010. Available from: http://hdl.handle.net/10588/43cf70da-fac1-41d5-be95-213521128c52

University of Alberta

14. Al-Hallak, MHD Kamal. Inhalable nanoparticles in lung cancer treatment; efficacy, safety, distribution and nanoparticle-macrophage interactions.

Degree: PhD, Faculty of Pharmacy and Pharmaceutical Sciences, 2012, University of Alberta

URL: https://era.library.ualberta.ca/files/mk61rj53p

► In 2002, lung cancer was responsible for 17.6% of the total worldwide deaths from cancer. Beyond the three traditional forms of cancer treatment, surgery, radiation… (more)

▼ In 2002, lung cancer was responsible for 17.6% of the total worldwide deaths from cancer. Beyond the three traditional forms of cancer treatment, surgery, radiation therapy, and chemotherapy, targeted drug delivery therapy has shown to be a potential treatment option. The design of a successful delivery system requires consideration of many factors, some of which include (i) the location and main organ(s) affected; (ii) the complexity of the associated physiological changes; (iii) the changes in receptor expression in cancerous cells; (iv) the physiochemical properties of the delivery system; (v) the interactions between the cancerous cells and other adjuvant cells, such as macrophages, with the delivery system; and (vi) the safety and tolerability of the delivery system. Considering the above factors of a successful delivery system, the aim of the present work was to design an innovative delivery system for lung cancer treatment incorporating inhalable nanoparticles (NP). To achieve this goal, several objectives were developed: (i) to investigate the interactions of different NP formulations with macrophages and the resulting effects on the behavior of macrophages; (ii) to assess and correlate the pulmonary toxicity of inhalable NPs using in vivo and in vitro methods; (iii) to develop a method to assess in real-time the effect of the formulation modifications on the uptake by macrophages of NPs; (iv) to assess the in vivo efficacy of an innovative formulation of effervescent inhalable NPs, thus actively releasing NPs; and finally, (v) to investigate the distribution of effervescent inhalable NPs after pulmonary delivery. Our results demonstrate that after exposure to NPs, macrophages undergo cellular changes to gain the ability to produce Th1 cytokines that are able to affect the viability of cancerous cells. The tolerability of inhalable NPs was related mainly to the additives used in the NP formulation. There was a good correlation between the in vivo and in vitro results. Effervescent inhalable NPs proved to be an effective and tolerable treatment for lung cancer treatment. Whole body autoradiography showed that inhalable NPs were able to achieve deep lung deposition and become distributed in time over the whole lung with some extra-pulmonary distribution.

Subjects/Keywords: inhalable nanoparticles; Lung cancer; Macrophages

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Al-Hallak, M. K. (2012). Inhalable nanoparticles in lung cancer treatment; efficacy, safety, distribution and nanoparticle-macrophage interactions. (Doctoral Dissertation). University of Alberta. Retrieved from https://era.library.ualberta.ca/files/mk61rj53p

Chicago Manual of Style (16^th Edition):

Al-Hallak, MHD Kamal. “Inhalable nanoparticles in lung cancer treatment; efficacy, safety, distribution and nanoparticle-macrophage interactions.” 2012. Doctoral Dissertation, University of Alberta. Accessed February 23, 2020. https://era.library.ualberta.ca/files/mk61rj53p.

MLA Handbook (7^th Edition):

Al-Hallak, MHD Kamal. “Inhalable nanoparticles in lung cancer treatment; efficacy, safety, distribution and nanoparticle-macrophage interactions.” 2012. Web. 23 Feb 2020.

Vancouver:

Al-Hallak MK. Inhalable nanoparticles in lung cancer treatment; efficacy, safety, distribution and nanoparticle-macrophage interactions. [Internet] [Doctoral dissertation]. University of Alberta; 2012. [cited 2020 Feb 23]. Available from: https://era.library.ualberta.ca/files/mk61rj53p.

Council of Science Editors:

Al-Hallak MK. Inhalable nanoparticles in lung cancer treatment; efficacy, safety, distribution and nanoparticle-macrophage interactions. [Doctoral Dissertation]. University of Alberta; 2012. Available from: https://era.library.ualberta.ca/files/mk61rj53p

University of Alberta

15. Noice, Lori. A Quantitative Analysis of Four Dimensional Computed Tomography.

Degree: MS, Physics, 2010, University of Alberta

URL: https://era.library.ualberta.ca/files/0z708x912

► This project assesses the four dimensional computed tomography (4DCT) capabilities of the Philips Brilliance Big Bore CT scanner (Philips Medical Systems, Cleveland, OH). A mechanical… (more)

Subjects/Keywords: 4DCT, CT, lung, motion management

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Noice, L. (2010). A Quantitative Analysis of Four Dimensional Computed Tomography. (Masters Thesis). University of Alberta. Retrieved from https://era.library.ualberta.ca/files/0z708x912

Chicago Manual of Style (16^th Edition):

Noice, Lori. “A Quantitative Analysis of Four Dimensional Computed Tomography.” 2010. Masters Thesis, University of Alberta. Accessed February 23, 2020. https://era.library.ualberta.ca/files/0z708x912.

MLA Handbook (7^th Edition):

Noice, Lori. “A Quantitative Analysis of Four Dimensional Computed Tomography.” 2010. Web. 23 Feb 2020.

Vancouver:

Noice L. A Quantitative Analysis of Four Dimensional Computed Tomography. [Internet] [Masters thesis]. University of Alberta; 2010. [cited 2020 Feb 23]. Available from: https://era.library.ualberta.ca/files/0z708x912.

Council of Science Editors:

Noice L. A Quantitative Analysis of Four Dimensional Computed Tomography. [Masters Thesis]. University of Alberta; 2010. Available from: https://era.library.ualberta.ca/files/0z708x912

Texas A&M University

16. Partouche Sebban, Julien 1978-. Clinical Implementation of Hypofractionated Radiation therapy for Lung Malignancies.

Degree: 2012, Texas A&M University

URL: http://hdl.handle.net/1969.1/157710

► For patients with oligometastases, metastases limited in number and site, the use of radiation therapy treatment with a hypofractionated dose scheme has been proposed as… (more)

▼ For patients with oligometastases, metastases limited in number and site, the use of radiation therapy treatment with a hypofractionated dose scheme has been proposed as a potential ablative approach. There are a limited number of prospective studies looking at hypofractionated radiation therapy (HRT) for lung oligometastasis. Normal lung tissue complication and radiation planning technique are significant limiting factors for the implementation of hypofractionated lung metastasis. The problem statement of this study is how to improve the clinical implementation of HRT for lung metastasis exploring lung toxicity predictors, and developing an efficient radiation planning method. In the first study, we analyzed the dose distribution for 28 patients with lung oligometastasis and treated with HRT to multiple metastases in the lungs. We identified several significant predictors for lung radiation pneumonitis (RP) including the mean lung dose (MLD), V13 and V20. In addition a dose-effect relation between the lung normalized total dose (NTD) and RP may exist up to 48 Gy in three fractions. The dose-response parameters derived in our study appear to agree with other hypofractionated results published in the literature. In the second study, we used an inverse planning algorithm to develop a new radiation planning method by limiting the number of segments per beam angle down to 1 segment. Single segment plans were able to significantly improve tumor coverage and conformality, reduce the risk of lung RP, while simplifying the planning process and delivery. Target conformality and normal lung tissue sparing did not gain much improvement from an increase of plan complexity to five segments over the simplified one segment technique. The automation of our method is a good alternative to more traditional methods and offers significant dosimetric benefits. In the third study, we verified the single segment planning technique via patient specific quality assurance (QA) in a motion phantom. We found good agreement between calculated and measured doses via thermoluminescent detectors (TLD) inside the target. A dose to distance agreement of 3%/3 mm and 2%/2 mm between calculation and film measurements for representative plans in a motion phantom was verified at 98.99% and 97.15%, respectively. Advisors/Committee Members: Ford, John R (advisor), Poston, John W (committee member), Braby, Leslie A (committee member), Walker, Michael (committee member).

Subjects/Keywords: radiation therapy; lung; hypofractionated

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Partouche Sebban, J. 1. (2012). Clinical Implementation of Hypofractionated Radiation therapy for Lung Malignancies. (Thesis). Texas A&M University. Retrieved from http://hdl.handle.net/1969.1/157710

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Partouche Sebban, Julien 1978-. “Clinical Implementation of Hypofractionated Radiation therapy for Lung Malignancies.” 2012. Thesis, Texas A&M University. Accessed February 23, 2020. http://hdl.handle.net/1969.1/157710.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Partouche Sebban, Julien 1978-. “Clinical Implementation of Hypofractionated Radiation therapy for Lung Malignancies.” 2012. Web. 23 Feb 2020.

Vancouver:

Partouche Sebban J1. Clinical Implementation of Hypofractionated Radiation therapy for Lung Malignancies. [Internet] [Thesis]. Texas A&M University; 2012. [cited 2020 Feb 23]. Available from: http://hdl.handle.net/1969.1/157710.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Partouche Sebban J1. Clinical Implementation of Hypofractionated Radiation therapy for Lung Malignancies. [Thesis]. Texas A&M University; 2012. Available from: http://hdl.handle.net/1969.1/157710

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Dundee

17. Buchanan, Deans. The clinical care of patients with lung cancer : identifying and supporting those with unmet care needs.

Degree: Thesis (M.D.), 2010, University of Dundee

URL: http://hdl.handle.net/10588/1047

► Lung cancer has developed from a rare condition into the leading cause of cancerrelated death in the United Kingdom. Lung cancer patients face a disease… (more)

▼ Lung cancer has developed from a rare condition into the leading cause of cancerrelated death in the United Kingdom. Lung cancer patients face a disease with a high symptom burden, increased psychosocial needs and a high mortality. Supportive care needs are often relevant from diagnosis. Despite this there are no clear follow-up structures for lung cancer patients that address both cancer management and supportive care. The aims of this study were to evaluate supportive care needs, assess predictors of such needs and identify factors which could aid service provision within Stobhill lung cancer services. Methods Supportive care needs were measured using an adapted Palliative Outcome Scale (POS), incorporated within a larger questionnaire. All lung cancer patients attending the clinic could complete this questionnaire. Respiratory symptoms, performance status, service usage, preferences and satisfaction were also assessed. Data were stratified to allow evaluation of three clinical groupings: all patients, newly diagnosed patients and patients in the last three months of life. Analyses were phased: descriptive analyses, univariate tests of association and multivariate regression. Results Three hundred and fifty three lung cancer patients completed questionnaires. The high symptom burden in lung cancer was confirmed. Anxiety, pain and dyspnoea were identified as the key issues. Poor performance status was identified to be an independent predictor of increased POS score, increased anxiety, increased pain and increased dyspnoea. There was no independent relationship between POS and survival. Although the majority of patients were satisfied with the care received, there was uncertainty regarding who was in charge of care and some disparity in preferred structure for follow-up. Conclusions Despite recent advances in lung cancer management, improvements are still required to address unmet supportive care needs of patients. Particular attention should be given to those with poorer performance status to effectively identify and meet such needs.

Subjects/Keywords: Lung cancer; Supportive care; Symptoms

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Buchanan, D. (2010). The clinical care of patients with lung cancer : identifying and supporting those with unmet care needs. (Doctoral Dissertation). University of Dundee. Retrieved from http://hdl.handle.net/10588/1047

Chicago Manual of Style (16^th Edition):

Buchanan, Deans. “The clinical care of patients with lung cancer : identifying and supporting those with unmet care needs.” 2010. Doctoral Dissertation, University of Dundee. Accessed February 23, 2020. http://hdl.handle.net/10588/1047.

MLA Handbook (7^th Edition):

Buchanan, Deans. “The clinical care of patients with lung cancer : identifying and supporting those with unmet care needs.” 2010. Web. 23 Feb 2020.

Vancouver:

Buchanan D. The clinical care of patients with lung cancer : identifying and supporting those with unmet care needs. [Internet] [Doctoral dissertation]. University of Dundee; 2010. [cited 2020 Feb 23]. Available from: http://hdl.handle.net/10588/1047.

Council of Science Editors:

Buchanan D. The clinical care of patients with lung cancer : identifying and supporting those with unmet care needs. [Doctoral Dissertation]. University of Dundee; 2010. Available from: http://hdl.handle.net/10588/1047

University of Manchester

18. Pariollaud, Marie. Role of REV-ERBα in the regulation of lung inflammation.

Degree: PhD, 2017, University of Manchester

URL: https://www.research.manchester.ac.uk/portal/en/theses/role-of-reverbalpha-in-the-regulation-of-lung-inflammation(140db598-4670-4605-8c8e-f589fec33e69).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.703035

► The clock-controlled nuclear receptor REV-ERBα has emerged as a critical regulator of multiple pathways involved in metabolism, development and immunity. Recent evidence has highlighted a… (more)

▼ The clock-controlled nuclear receptor REV-ERBα has emerged as a critical regulator of multiple pathways involved in metabolism, development and immunity. Recent evidence has highlighted a major role for the clock in epithelial cells regulating lung inflammation, mediated by control of neutrophil chemokine expression. In this thesis, I examined the role of REV-ERBα in pulmonary immunity, using in-vivo gene targeting and nebulised lipopolysaccharide (LPS), a model for gram-negative bacterial infection, ex-vivo cell biology approaches and in vitro cell models. Initial studies of Rev-Erbα knock-out mice revealed an increase in pulmonary neutrophilia and inflammation upon aerosolised LPS challenge. Moreover, by selectively deleting the REV-ERBα DNA binding domain (DBD) in the mouse bronchial epithelium, I observed exaggerated inflammatory responses to LPS and augmented CXCL5 secretion. Interestingly, a dual deletion of REV-ERBα DBD and REV-ERBβ in mouse bronchial epithelium had a more dramatic effect on neutrophil recruitment and chemokine secretion than deletion of just the REV-ERBα DBD; in both basal and bacterial challenged conditions. Ex-vivo analysis revealed bronchial epithelial cells and macrophages both responded to novel REV-ERBα synthetic ligand GSK1362 but displayed divergent inflammatory responses in presence of this compound. Finally, I observed a striking loss of REV-ERBα protein upon pro-inflammatory challenge. Further analysis revealed this degradation was dependent on the 26S proteasome and driven by sumoylation and ubiquitination of REV-ERBα. However, by using novel REV-ERB ligand GSK1362, these post-translational modifications were blocked and the protein protected from degradation. Collectively, my results propose a new model for a central role for REV-ERBα in conferring clock control to lung neutrophilic inflammation. I have also identified a feed-forward circuit activated by inflammatory stimuli, leading to suppression of the endogenous anti-inflammatory REV-ERBα protein. Finally, I have discovered a novel mechanism for small-molecule regulation of REV-ERBα, operating via suppression of endogenous protein ubiquitination process. These observations implicate REV-ERBα as a novel therapeutic target in human inflammatory disease.

Subjects/Keywords: 616.2; Inflammation; Lung; REV-ERB

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Pariollaud, M. (2017). Role of REV-ERBα in the regulation of lung inflammation. (Doctoral Dissertation). University of Manchester. Retrieved from https://www.research.manchester.ac.uk/portal/en/theses/role-of-reverbalpha-in-the-regulation-of-lung-inflammation(140db598-4670-4605-8c8e-f589fec33e69).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.703035

Chicago Manual of Style (16^th Edition):

Pariollaud, Marie. “Role of REV-ERBα in the regulation of lung inflammation.” 2017. Doctoral Dissertation, University of Manchester. Accessed February 23, 2020. https://www.research.manchester.ac.uk/portal/en/theses/role-of-reverbalpha-in-the-regulation-of-lung-inflammation(140db598-4670-4605-8c8e-f589fec33e69).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.703035.

MLA Handbook (7^th Edition):

Pariollaud, Marie. “Role of REV-ERBα in the regulation of lung inflammation.” 2017. Web. 23 Feb 2020.

Vancouver:

Pariollaud M. Role of REV-ERBα in the regulation of lung inflammation. [Internet] [Doctoral dissertation]. University of Manchester; 2017. [cited 2020 Feb 23]. Available from: https://www.research.manchester.ac.uk/portal/en/theses/role-of-reverbalpha-in-the-regulation-of-lung-inflammation(140db598-4670-4605-8c8e-f589fec33e69).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.703035.

Council of Science Editors:

Pariollaud M. Role of REV-ERBα in the regulation of lung inflammation. [Doctoral Dissertation]. University of Manchester; 2017. Available from: https://www.research.manchester.ac.uk/portal/en/theses/role-of-reverbalpha-in-the-regulation-of-lung-inflammation(140db598-4670-4605-8c8e-f589fec33e69).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.703035

University of Minnesota

19. Turgut, Aylin. Generating cells for lung tissue engineering.

Degree: MS, Stem Cell Biology, 2014, University of Minnesota

URL: http://hdl.handle.net/11299/165640

► Decellularization of essential organs such as the lung has become an integral part of regenerative medicine. As the availability of donors is very low reseeding… (more)

Subjects/Keywords: Bioreactor; Decellularize; Differentiation; Endoderm; Lung

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Turgut, A. (2014). Generating cells for lung tissue engineering. (Masters Thesis). University of Minnesota. Retrieved from http://hdl.handle.net/11299/165640

Chicago Manual of Style (16^th Edition):

Turgut, Aylin. “Generating cells for lung tissue engineering.” 2014. Masters Thesis, University of Minnesota. Accessed February 23, 2020. http://hdl.handle.net/11299/165640.

MLA Handbook (7^th Edition):

Turgut, Aylin. “Generating cells for lung tissue engineering.” 2014. Web. 23 Feb 2020.

Vancouver:

Turgut A. Generating cells for lung tissue engineering. [Internet] [Masters thesis]. University of Minnesota; 2014. [cited 2020 Feb 23]. Available from: http://hdl.handle.net/11299/165640.

Council of Science Editors:

Turgut A. Generating cells for lung tissue engineering. [Masters Thesis]. University of Minnesota; 2014. Available from: http://hdl.handle.net/11299/165640

North Carolina State University

20. Cesta, Mark Francis. Contribution of Bacterial Lipopolysaccharide to Carbon Nanotube- and Vanadium Pentoxide-Induced Pulmonary Fibrosis in Rats.

Degree: PhD, Comparative Biomedical Sciences, 2010, North Carolina State University

URL: http://www.lib.ncsu.edu/resolver/1840.16/6162

► Pulmonary fibrosis is typically accompanied by inflammation, which is thought to play a role in its pathogenesis, and occurs with occupational exposure to particulates and… (more)

▼ Pulmonary fibrosis is typically accompanied by inflammation, which is thought to play a role in its pathogenesis, and occurs with occupational exposure to particulates and metals, such as asbestos and vanadium pentoxide (V2O5). Lipopolysaccharide (LPS), a model of acute lung injury and inflammation, chronic bronchitis, and pulmonary fibrosis, upregulates platelet-derived growth factor receptor (PDGF-RÎ±) in rat lung fibroblasts (RLF). PDGF, a potent mitogen and chemoattractant for mesenchymal cells, is an important mediator in fibrotic lung diseases. This dissertation examines the effects of pre-existing inflammation, induced by LPS, on carbon nanotube (CNT)- and V2O5-induced pulmonary fibrosis in rats and the involvement of PDGF signaling. Rats were pretreated with 2.5 mg/kg LPS by intranasal aspiration, followed 24 hr later by 4 mg /kg CNT, carbon black (CB), or V2O5 administered by intratracheal instillation. Total and differential cell counts, lactate dehydrogenase (LDH), total protein, and PDGF and transforming growth factor-Î² (TGF-Î²) protein levels (by ELISA) were examined in bronchoalveolar lavage (BAL) fluid of control and CB- and MWCNT â€“exposed rats. Lungs from all animals were collected for histopathological analysis, immunohistochemistry, and qPCR of the Pdgf-a, Pdgf-c, Pdgf-rÎ±, and Tgf-Î² genes. Pdgf-a, Pdgf-c, Pdgf-rÎ±, Tgf-Î², and Col1a2 gene expression was also measured in vitro in RLF and NR8383 rat alveolar macrophages in response to CNT or CB with and without LPS. In vivo, CNT and CB caused fibroproliferative, granulomatous lesions, which were located primarily in the alveolar ducts and alveoli. Pretreatment with LPS significantly increased collagen deposition associated with these lesions. In the BAL fluid, LPS pretreatment lead to increases in LDH, total protein, and PDGF-AA protein in rats exposed to MWCNT, and an increase in inflammatory cells in CB-exposed rats compared to controls. In vitro, LPS stimulated Pdgf-rÎ± gene expression in RLF, and LPS and nanoparticles synergistically increased Pdgf-a expression in NR8383 cells. Combined LPS/V2O5 exposure augmented V2O5-induced pulmonary inflammation, airway epithelial necrosis, and fibrosis and amplified in vivo collagen gene expression. The airway lesions were of particular interest because LPS pretreatment increased the incidence of bronchiolitis obliterans-like lesions, including subepithelial fibrosis and intraluminal fibrotic polyps. These data confirm that LPS pretreatment augments the fibrotic effects of CNT and V2O5 in rats, which likely involves enhanced PDGF signaling. This dissertation provides evidence that pre-existing pulmonary inflammation, as occurs with chronic obstructive pulmonary diseases or cigarette smoking, can enhance pulmonary fibrotic responses to environmental agents. Furthermore, exposure to environmental LPS may play a role in the pathogenesis of some fibrotic lung diseases. Advisors/Committee Members: Dr. James C. Bonner, Committee Co-Chair (advisor), Dr. David E. Malarkey, Committee Member (advisor), Dr. Kenneth B. Adler, Committee Member (advisor), Dr. Philip L. Sannes, Committee Chair (advisor).

Subjects/Keywords: lung; lipoplysaccharide; nanotube; vanadium; fibrosis

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Cesta, M. F. (2010). Contribution of Bacterial Lipopolysaccharide to Carbon Nanotube- and Vanadium Pentoxide-Induced Pulmonary Fibrosis in Rats. (Doctoral Dissertation). North Carolina State University. Retrieved from http://www.lib.ncsu.edu/resolver/1840.16/6162

Chicago Manual of Style (16^th Edition):

Cesta, Mark Francis. “Contribution of Bacterial Lipopolysaccharide to Carbon Nanotube- and Vanadium Pentoxide-Induced Pulmonary Fibrosis in Rats.” 2010. Doctoral Dissertation, North Carolina State University. Accessed February 23, 2020. http://www.lib.ncsu.edu/resolver/1840.16/6162.

MLA Handbook (7^th Edition):

Cesta, Mark Francis. “Contribution of Bacterial Lipopolysaccharide to Carbon Nanotube- and Vanadium Pentoxide-Induced Pulmonary Fibrosis in Rats.” 2010. Web. 23 Feb 2020.

Vancouver:

Cesta MF. Contribution of Bacterial Lipopolysaccharide to Carbon Nanotube- and Vanadium Pentoxide-Induced Pulmonary Fibrosis in Rats. [Internet] [Doctoral dissertation]. North Carolina State University; 2010. [cited 2020 Feb 23]. Available from: http://www.lib.ncsu.edu/resolver/1840.16/6162.

Council of Science Editors:

Cesta MF. Contribution of Bacterial Lipopolysaccharide to Carbon Nanotube- and Vanadium Pentoxide-Induced Pulmonary Fibrosis in Rats. [Doctoral Dissertation]. North Carolina State University; 2010. Available from: http://www.lib.ncsu.edu/resolver/1840.16/6162

Rochester Institute of Technology

21. Steffens, Jonathan. Comparison of particle deposition for realistic adult and adolescent upper airway geometries using unsteady computational fluid dynamics.

Degree: Mechanical Engineering, 2010, Rochester Institute of Technology

URL: https://scholarworks.rit.edu/theses/7253

► Particle deposition in the respiratory tract is studied in order to better understand the negative health effects due to cigarette smoke inhalation. Until recently, idealized… (more)

▼ Particle deposition in the respiratory tract is studied in order to better understand the negative health effects due to cigarette smoke inhalation. Until recently, idealized models of the respiratory airways based on the original Weibel model have been used to calculate deposition. These models consist of symmetric bifurcating airways and do not take into account variations of airway diameter, and asymmetry in the human respiratory tract. Until recently, little work has been done to accurately recreate the entire upper respiratory tract including the oral cavity, pharynx, and larynx. Technological improvement has changed the way in which researchers approach this problem. With the advent of high resolution scans of the respiratory tract, accurate replica models can be created to better predict cigarette smoke particle (CSP) deposition. These models recreate actual lung geometries found in patients. For this thesis, two realistic geometric models are created. One is based on an adult male and the other on an adolescent male. CSP deposition is determined for both models in order to compare the difference cased by age in smoking. In addition, an unsteady breathing curve, indicative of realistic smoking behavior is utilized to more accurately represent the breathing conditions. Both models consist of the oral cavity, throat, larynx, trachea, and first five to seven generations of the lungs. The adult model is based on a dental cast of the mouth, a CT scan of the throat and larynx, and images based on the National Institute of Health's Visible Human Project for the tracheobronchial tree. The adolescent model is based upon a scaled oral cavity and CT scans of the rest of the reparatory tract. The program 3D Doctor is used to reconstruct the two dimensional CT scan images into a three dimensional model. VPSculpt and SolidWorks are used to combine the different parts of the models and clean up the geometry. The geometry is meshed in Gambit and exported to the Computational Fluid Dynamics (CFD) software package Fluent to perform the fluid flow and particle deposition analysis. The Fluent Discrete Phase Model (DPM) is used to determine particle trajectories and deposition. It is found that deposition increases with the size of the inhaled particles. Particles tend to deposit towards the back of the throat, the area of the trachea just below the glottis, and at bifurcations in the airways. However, when compared to other studies in literature, deposition tended to be higher with smaller particle sizes, but more comparable with larger particle sizes. Adolescent deposition was found to be lower than adult deposition for all particle sizes. Advisors/Committee Members: Robinson, Risa.

Subjects/Keywords: Adolescent; CFD; Lung morphology; Unsteady

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Steffens, J. (2010). Comparison of particle deposition for realistic adult and adolescent upper airway geometries using unsteady computational fluid dynamics. (Thesis). Rochester Institute of Technology. Retrieved from https://scholarworks.rit.edu/theses/7253

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Steffens, Jonathan. “Comparison of particle deposition for realistic adult and adolescent upper airway geometries using unsteady computational fluid dynamics.” 2010. Thesis, Rochester Institute of Technology. Accessed February 23, 2020. https://scholarworks.rit.edu/theses/7253.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Steffens, Jonathan. “Comparison of particle deposition for realistic adult and adolescent upper airway geometries using unsteady computational fluid dynamics.” 2010. Web. 23 Feb 2020.

Vancouver:

Steffens J. Comparison of particle deposition for realistic adult and adolescent upper airway geometries using unsteady computational fluid dynamics. [Internet] [Thesis]. Rochester Institute of Technology; 2010. [cited 2020 Feb 23]. Available from: https://scholarworks.rit.edu/theses/7253.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Steffens J. Comparison of particle deposition for realistic adult and adolescent upper airway geometries using unsteady computational fluid dynamics. [Thesis]. Rochester Institute of Technology; 2010. Available from: https://scholarworks.rit.edu/theses/7253

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Western Australia

22. Sng, Joo Li Natasha. The role of β-catenin in activated EGFR-driven lung tumourigenesis.

Degree: M.Med.Sc., 2011, University of Western Australia

URL: http://repository.uwa.edu.au:80/R/?func=dbin-jump-full&object_id=32218&local_base=GEN01-INS01

►

Lung cancer is associated with a high mortality rate, with Non-Small Cell Lung Cancer (NSCLC) accounting for the majority of cases. Mutations in the epidermal… (more)

▼

Lung cancer is associated with a high mortality rate, with Non-Small Cell Lung Cancer (NSCLC) accounting for the majority of cases. Mutations in the epidermal growth factor receptor (EGFR) kinase domain have been shown to confer tumourigenic behaviour in NSCLC. At present, there is limited knowledge of lung cancer development and of the mechanism of resistance of these tumours to novel therapeutic approaches using EGFR inhibitors. Genome-wide expression analysis has revealed that cyclin D1 is one of the most strongly down-regulated genes following treatment of H1975 lung tumour cells with an inhibitor of tyrosine kinase. Additionally, nuclear accumulation of β-catenin correlates with the blast crisis phase of CML, which is driven by the oncogenic tyrosine kinase Bcr- Abl. These two observations have led us to hypothesize that oncogenic EGFR mutations trigger tyrosine phosphorylation of β-catenin, thereby inducing the expression of cell cycle regulators such as cyclin D1. To investigate this potential cross-talk between EGFR and Wnt signalling pathways, we used established NSCLC cell lines and also developed a BEAS-2B isogenic cell line to perform a series of gene expression studies. Using this approach, we found that NSCLC cell lines harbouring EGFR mutations express higher levels of active β-catenin in the cytoplasm and nucleus compared to cell lines with wild-type EGFR. This was further verified in the BEAS-2B isogenic cell line. Moreover, mutant EGFR was found to directly activate the Wnt/ β-catenin pathway and this could play a role in the development of resistance to EGFR inhibitors.

Increased levels of β-catenin were also observed in both murine and human primary lung cancer samples containing mutant EGFR. These findings suggest that β-catenin could be a novel therapeutic target in lung cancer. Ongoing studies in this area involve the development of a β-catenin knock-out mouse model to investigate how the absence of β-catenin affects lung tumourigenesis and to identify possible new therapeutic approaches for this disease.

Lung cancer is associated with a high mortality rate, with Non-Small Cell Lung Cancer (NSCLC) accounting for the majority of cases. Mutations in the epidermal growth factor receptor (EGFR) kinase domain have been shown to confer tumourigenic behaviour in NSCLC. At present, there is limited knowledge of lung cancer development and of the mechanism of resistance of these tumours to novel therapeutic approaches using EGFR inhibitors. Genome-wide expression analysis has revealed that cyclin D1 is one of the most strongly down-regulated genes following treatment of H1975 lung tumour cells with an inhibitor of tyrosine kinase. Additionally, nuclear accumulation of β-catenin correlates with the blast crisis phase of CML, which is driven by the oncogenic tyrosine kinase Bcr- Abl. These two observations have led us to hypothesize that oncogenic EGFR mutations trigger tyrosine phosphorylation of β-catenin, thereby inducing the expression of cell cycle regulators such as cyclin D1. To…

Subjects/Keywords: EGFR; Lung tumour; Beta-catenin

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Sng, J. L. N. (2011). The role of β-catenin in activated EGFR-driven lung tumourigenesis. (Masters Thesis). University of Western Australia. Retrieved from http://repository.uwa.edu.au:80/R/?func=dbin-jump-full&object_id=32218&local_base=GEN01-INS01

Chicago Manual of Style (16^th Edition):

Sng, Joo Li Natasha. “The role of β-catenin in activated EGFR-driven lung tumourigenesis.” 2011. Masters Thesis, University of Western Australia. Accessed February 23, 2020. http://repository.uwa.edu.au:80/R/?func=dbin-jump-full&object_id=32218&local_base=GEN01-INS01.

MLA Handbook (7^th Edition):

Sng, Joo Li Natasha. “The role of β-catenin in activated EGFR-driven lung tumourigenesis.” 2011. Web. 23 Feb 2020.

Vancouver:

Sng JLN. The role of β-catenin in activated EGFR-driven lung tumourigenesis. [Internet] [Masters thesis]. University of Western Australia; 2011. [cited 2020 Feb 23]. Available from: http://repository.uwa.edu.au:80/R/?func=dbin-jump-full&object_id=32218&local_base=GEN01-INS01.

Council of Science Editors:

Sng JLN. The role of β-catenin in activated EGFR-driven lung tumourigenesis. [Masters Thesis]. University of Western Australia; 2011. Available from: http://repository.uwa.edu.au:80/R/?func=dbin-jump-full&object_id=32218&local_base=GEN01-INS01

University of Western Australia

23. Logie, Karla Maree. Structural and functional respiratory abnormalities in a contemporary cohort of 9-11 year old children born very preterm.

Degree: PhD, 2012, University of Western Australia

URL: http://repository.uwa.edu.au:80/R/?func=dbin-jump-full&object_id=40070&local_base=GEN01-INS01

►

[Truncated abstract] Advances in neonatal care have shifted the pathophysiology of preterm birth and bronchopulmonary dysplasia (BPD) such that the impact of contemporaneous preterm birth… (more)

▼

[Truncated abstract] Advances in neonatal care have shifted the pathophysiology of preterm birth and bronchopulmonary dysplasia (BPD) such that the impact of contemporaneous preterm birth on long-term respiratory health remains unclear. We aimed to quantify midchildhood respiratory function and structure in children born very preterm (≤ 32 weeks gestational age), regardless of neonatal BPD status. We investigated if these outcomes were associated with neonatal characteristics and respiratory symptoms. Lung structure was assessed using a modified low-dose chest computed tomography (CT) protocol and lung function assessed by tests of forced oscillation (FOT), static lung volumes, spirometry and gas transfer (DLCO). We studied 158 children in total, including 46 term controls and 112 preterm children born ≤ 32 weeks gestation with 69 children diagnosed with BPD during the neonatal period. All preterm children received neonatal care at King Edward Memorial Hospital, Perth. Neonatal demographics of gender, gestation, birth weight and durations of supplemental oxygen, and CPAP accurately represented the very preterm population born during this era, with only duration of mechanical ventilation (MV) higher in the study BPD group. Respiratory symptoms were more prevalent in preterm children than a local birth cohort sample, with similar prevalences of symptoms between the first year of life and at mid-childhood. We compared the preterm cohort to the term cohort for each lung function measurement, with further analysis according to BPD status. Lung volumes measurements revealed increased FRC, FRC/TLC (%) and LCI in the preterm cohort, but no differences in VC, TLC, RV or RV/TLC (%), with increased FRC also associated with use of asthma medications in the preceding 3 months. Analysis of BPD and Non-BPD subgroups revealed FRC/TLC (%) to be significantly higher in the BPD compared to term children with no other differences between term, Non-BPD or BPD groups...

[Truncated abstract] Advances in neonatal care have shifted the pathophysiology of preterm birth and bronchopulmonary dysplasia (BPD) such that the impact of contemporaneous preterm birth on long-term respiratory health remains unclear. We aimed to quantify midchildhood respiratory function and structure in children born very preterm (≤ 32 weeks gestational age), regardless of neonatal BPD status. We investigated if these outcomes were associated with neonatal characteristics and respiratory symptoms. Lung structure was assessed using a modified low-dose chest computed tomography (CT) protocol and lung function assessed by tests of forced oscillation (FOT), static lung volumes, spirometry and gas transfer (DLCO). We studied 158 children in total, including 46 term controls and 112 preterm children born ≤ 32 weeks gestation with 69 children diagnosed with BPD during the neonatal period. All preterm children received neonatal care at King Edward Memorial Hospital, Perth. Neonatal demographics of gender, gestation, birth weight and durations of supplemental oxygen, and…

Subjects/Keywords: Preterm children; Lung function; Structure

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Logie, K. M. (2012). Structural and functional respiratory abnormalities in a contemporary cohort of 9-11 year old children born very preterm. (Doctoral Dissertation). University of Western Australia. Retrieved from http://repository.uwa.edu.au:80/R/?func=dbin-jump-full&object_id=40070&local_base=GEN01-INS01

Chicago Manual of Style (16^th Edition):

Logie, Karla Maree. “Structural and functional respiratory abnormalities in a contemporary cohort of 9-11 year old children born very preterm.” 2012. Doctoral Dissertation, University of Western Australia. Accessed February 23, 2020. http://repository.uwa.edu.au:80/R/?func=dbin-jump-full&object_id=40070&local_base=GEN01-INS01.

MLA Handbook (7^th Edition):

Logie, Karla Maree. “Structural and functional respiratory abnormalities in a contemporary cohort of 9-11 year old children born very preterm.” 2012. Web. 23 Feb 2020.

Vancouver:

Logie KM. Structural and functional respiratory abnormalities in a contemporary cohort of 9-11 year old children born very preterm. [Internet] [Doctoral dissertation]. University of Western Australia; 2012. [cited 2020 Feb 23]. Available from: http://repository.uwa.edu.au:80/R/?func=dbin-jump-full&object_id=40070&local_base=GEN01-INS01.

Council of Science Editors:

Logie KM. Structural and functional respiratory abnormalities in a contemporary cohort of 9-11 year old children born very preterm. [Doctoral Dissertation]. University of Western Australia; 2012. Available from: http://repository.uwa.edu.au:80/R/?func=dbin-jump-full&object_id=40070&local_base=GEN01-INS01

Universiteit Utrecht

24. Breeveld, A.R. Shape of the exposure response relation for crystalline silica and risk of lung cancer.

Degree: 2011, Universiteit Utrecht

URL: http://dspace.library.uu.nl:8080/handle/1874/209135

► Crystalline silica exposure mostly occurs in occupational settings such as mining, construction, several industries (e.g. foundries) and agriculture. Occupational exposure to silica dust is known… (more)

Subjects/Keywords: crystalline silica; lung cancer

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Breeveld, A. R. (2011). Shape of the exposure response relation for crystalline silica and risk of lung cancer. (Masters Thesis). Universiteit Utrecht. Retrieved from http://dspace.library.uu.nl:8080/handle/1874/209135

Chicago Manual of Style (16^th Edition):

Breeveld, A R. “Shape of the exposure response relation for crystalline silica and risk of lung cancer.” 2011. Masters Thesis, Universiteit Utrecht. Accessed February 23, 2020. http://dspace.library.uu.nl:8080/handle/1874/209135.

MLA Handbook (7^th Edition):

Breeveld, A R. “Shape of the exposure response relation for crystalline silica and risk of lung cancer.” 2011. Web. 23 Feb 2020.

Vancouver:

Breeveld AR. Shape of the exposure response relation for crystalline silica and risk of lung cancer. [Internet] [Masters thesis]. Universiteit Utrecht; 2011. [cited 2020 Feb 23]. Available from: http://dspace.library.uu.nl:8080/handle/1874/209135.

Council of Science Editors:

Breeveld AR. Shape of the exposure response relation for crystalline silica and risk of lung cancer. [Masters Thesis]. Universiteit Utrecht; 2011. Available from: http://dspace.library.uu.nl:8080/handle/1874/209135

25. 坪内, 拡伸. Rikkunshito ameliorates bleomycin-induced acute lung injury in a ghrelin-independent manner : 六君子湯投与はブレオマイシン誘導性急性肺障害をグレリン非依存性に改善する.

Degree: 博士(医学), 2014, University of Miyazaki / 宮崎大学

URL: http://hdl.handle.net/10458/5039

以下に掲載:American Journal of Physiology - Lung Cellular and Molecular Physiology. 2014, 306, 3, p.L233-L245, doi:10.1152/ajplung.00096.2013.

Subjects/Keywords: rikkunshito; acute lung injury; ghrelin

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

坪内, �. (2014). Rikkunshito ameliorates bleomycin-induced acute lung injury in a ghrelin-independent manner : 六君子湯投与はブレオマイシン誘導性急性肺障害をグレリン非依存性に改善する. (Thesis). University of Miyazaki / 宮崎大学. Retrieved from http://hdl.handle.net/10458/5039

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

坪内, 拡伸. “Rikkunshito ameliorates bleomycin-induced acute lung injury in a ghrelin-independent manner : 六君子湯投与はブレオマイシン誘導性急性肺障害をグレリン非依存性に改善する.” 2014. Thesis, University of Miyazaki / 宮崎大学. Accessed February 23, 2020. http://hdl.handle.net/10458/5039.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

坪内, 拡伸. “Rikkunshito ameliorates bleomycin-induced acute lung injury in a ghrelin-independent manner : 六君子湯投与はブレオマイシン誘導性急性肺障害をグレリン非依存性に改善する.” 2014. Web. 23 Feb 2020.

Vancouver:

坪内 �. Rikkunshito ameliorates bleomycin-induced acute lung injury in a ghrelin-independent manner : 六君子湯投与はブレオマイシン誘導性急性肺障害をグレリン非依存性に改善する. [Internet] [Thesis]. University of Miyazaki / 宮崎大学; 2014. [cited 2020 Feb 23]. Available from: http://hdl.handle.net/10458/5039.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

坪内 �. Rikkunshito ameliorates bleomycin-induced acute lung injury in a ghrelin-independent manner : 六君子湯投与はブレオマイシン誘導性急性肺障害をグレリン非依存性に改善する. [Thesis]. University of Miyazaki / 宮崎大学; 2014. Available from: http://hdl.handle.net/10458/5039

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Penn State University

26. Crampsie, Melissa Ashley. INVESTIGATION OF THE MECHANISM OF ACTION OF ISOTHIOCYANATE.

Degree: PhD, Pharmacology, 2011, Penn State University

URL: https://etda.libraries.psu.edu/catalog/12391

► Goals of Dissertation Research Lung cancer is currently the leading cause of cancer deaths among men and women and has a survival rate of only… (more)

▼ Goals of Dissertation Research Lung cancer is currently the leading cause of cancer deaths among men and women and has a survival rate of only 16%. Because nearly 90% of lung cancer cases are attributed to smoking tobacco and tobacco related lung cancer has a latency period of 20-30 years from time of exposure to invasive disease, intervention before invasive disease with a chemical agent, termed chemoprevention, is a well suited approach for this particular disease. Research suggests that many natural compounds, often found in the human diet, have chemopreventive properties and are actively being explored and/or can make excellent lead compounds. Our lab, using rational drug design techniques, developed a novel isoselenocyanate compound known as phenylbutyl isoselenocyanate (ISC-4) based on naturally occurring compounds found in cruciferous vegetables. The central hypothesis of this research was that ISC-4, based on its design, would function as a potent and effective anti-cancer agent and could be used as a chemopreventive agent. Specific Aims Specific Aim 1: To determine the effects of replacing the sulfur atom of a panel of phenyl alkyl isothiocyanates with selenium to form a new panel of phenyl alkyl isoselenocyanates (Chapter 2). A structure activity study was performed on the panel of parent isothiocyanate compounds and the resulting panel of isoselenocyanate compounds to determine if mechanistic characteristics were retained and to ascertain a reason for increased activity. Specific Aim 2: Testing the hypothesis that ISC-4 has potential as a chemopreventive agent (Chapter 3). This drug was found to potently target and inhibit carcinogen bioactivation by cytochrome P450 enzymes, including the tobacco specific nitrosamine procarcinogen, N-nitrosyl ketone (NNK). When bioactivated, NNK can lead to mutations in DNA and ultimately result in tumorigenesis. A series of experiments were conducted to assess chemopreventive properties including bioavailability, anti-initiation, and DNA adduct studies, all of which were needed as proof of concept before performing an animal bioassay. Specific Aim 3: Testing ISC-4 as a chemopreventive agent in a lung cancer chemoprevention bioassay (Chapter 4). Using an A/J mouse model, ISC-4 at varying doses and along with its sulfur analog PBITC were tested for the ability to inhibit NNK induced lung tumorigenesis over a 24 week period of time. Original Breakthroughs and Findings Isoselenocyanate (ISC) compounds were actually found to have increased activity with cellular thiols compared to their corresponding sulfur analogs leading to the hypothesis that specific protein modifications and redox activity in the cell are responsible for the increased activities seen with the ISC compounds. As Phase I cytochrome P450s were identified early as a significant protein target of ISC-4, the cancer chemopreventive properties of this compound were explored. ISC-4 was found to be orally bioavailable, able to transcriptionally induce Phase II detoxification enzymes, and inhibit DNA adduct formation…

Subjects/Keywords: ISC-4; lung cancer; chemoprevention

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Crampsie, M. A. (2011). INVESTIGATION OF THE MECHANISM OF ACTION OF ISOTHIOCYANATE. (Doctoral Dissertation). Penn State University. Retrieved from https://etda.libraries.psu.edu/catalog/12391

Chicago Manual of Style (16^th Edition):

Crampsie, Melissa Ashley. “INVESTIGATION OF THE MECHANISM OF ACTION OF ISOTHIOCYANATE.” 2011. Doctoral Dissertation, Penn State University. Accessed February 23, 2020. https://etda.libraries.psu.edu/catalog/12391.

MLA Handbook (7^th Edition):

Crampsie, Melissa Ashley. “INVESTIGATION OF THE MECHANISM OF ACTION OF ISOTHIOCYANATE.” 2011. Web. 23 Feb 2020.

Vancouver:

Crampsie MA. INVESTIGATION OF THE MECHANISM OF ACTION OF ISOTHIOCYANATE. [Internet] [Doctoral dissertation]. Penn State University; 2011. [cited 2020 Feb 23]. Available from: https://etda.libraries.psu.edu/catalog/12391.

Council of Science Editors:

Crampsie MA. INVESTIGATION OF THE MECHANISM OF ACTION OF ISOTHIOCYANATE. [Doctoral Dissertation]. Penn State University; 2011. Available from: https://etda.libraries.psu.edu/catalog/12391

UCLA

27. Grimes, Brandon Scott. The immune contexture and genomic landscape of lung adenomatous premalignancy.

Degree: Clinical Research, 2017, UCLA

URL: http://www.escholarship.org/uc/item/5691h7fs

► Rationale/Objective: Over the past 30 years, the five-year survival rate for lung cancer has increased by only 5%. A better understanding of genomic alterations and… (more)

Subjects/Keywords: Biostatistics; Lung Cancer; Neoepitopes; Premalignancy

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Grimes, B. S. (2017). The immune contexture and genomic landscape of lung adenomatous premalignancy. (Thesis). UCLA. Retrieved from http://www.escholarship.org/uc/item/5691h7fs

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Grimes, Brandon Scott. “The immune contexture and genomic landscape of lung adenomatous premalignancy.” 2017. Thesis, UCLA. Accessed February 23, 2020. http://www.escholarship.org/uc/item/5691h7fs.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Grimes, Brandon Scott. “The immune contexture and genomic landscape of lung adenomatous premalignancy.” 2017. Web. 23 Feb 2020.

Vancouver:

Grimes BS. The immune contexture and genomic landscape of lung adenomatous premalignancy. [Internet] [Thesis]. UCLA; 2017. [cited 2020 Feb 23]. Available from: http://www.escholarship.org/uc/item/5691h7fs.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Grimes BS. The immune contexture and genomic landscape of lung adenomatous premalignancy. [Thesis]. UCLA; 2017. Available from: http://www.escholarship.org/uc/item/5691h7fs

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Saskatchewan

28. Babcock, Kerry Kent Ronald. The effects of anatomic resolution, respiratory variations and dose calculation methods on lung dosimetry.

Degree: 2010, University of Saskatchewan

URL: http://hdl.handle.net/10388/etd-01042010-110745

► The goal of this thesis was to explore the effects of dose resolution, respiratory variation and dose calculation method on dose accuracy. To achieve this,… (more)

▼ The goal of this thesis was to explore the effects of dose resolution, respiratory variation and dose calculation method on dose accuracy. To achieve this, two models of lung were created. The first model, called TISSUE, approximated the connective alveolar tissues of the lung. The second model, called BRANCH, approximated the lungs bronchial, arterial and venous branching networks. Both models were varied to represent the full inhalation, full exhalation and midbreath phases of the respiration cycle. To explore the effects of dose resolution and respiratory variation on dose accuracy, each model was converted into a CT dataset and imported into a Monte Carlo simulation. The resulting dose distributions were compared and contrasted against dose distributions from Monte Carlo simulations which included the explicit model geometries. It was concluded that, regardless of respiratory phase, the exclusion of the connective tissue structures in the CT representation did not significantly effect the accuracy of dose calculations. However, the exclusion of the BRANCH structures resulted in dose underestimations as high as 14% local to the branching structures. As lung density decreased, the overall dose accuracy marginally decreased. To explore the effects of dose calculation method on dose accuracy, CT representations of the lung models were imported into the Pinnacle³ treatment planning system. Dose distributions were calculated using the collapsed cone convolution method and compared to those derived using the Monte Carlo method. For both lung models, it was concluded that the accuracy of the collapsed cone algorithm decreased with decreasing density. At full inhalation lung density, the collapsed cone algorithm underestimated dose by as much as 15%. Also, the accuracy of the CCC method decreased with decreasing field size. Further work is needed to determine the source of the discrepancy. Advisors/Committee Members: Sidhu, Narinder, Pywell, Rob, Mayer, Monique, Xiao, Chijin, Kendall, Edward, Igarashi, Ru, Rogers, Dave.

Subjects/Keywords: accuracy; Monte Carlo; lung dosimetry

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Babcock, K. K. R. (2010). The effects of anatomic resolution, respiratory variations and dose calculation methods on lung dosimetry. (Thesis). University of Saskatchewan. Retrieved from http://hdl.handle.net/10388/etd-01042010-110745

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Babcock, Kerry Kent Ronald. “The effects of anatomic resolution, respiratory variations and dose calculation methods on lung dosimetry.” 2010. Thesis, University of Saskatchewan. Accessed February 23, 2020. http://hdl.handle.net/10388/etd-01042010-110745.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Babcock, Kerry Kent Ronald. “The effects of anatomic resolution, respiratory variations and dose calculation methods on lung dosimetry.” 2010. Web. 23 Feb 2020.

Vancouver:

Babcock KKR. The effects of anatomic resolution, respiratory variations and dose calculation methods on lung dosimetry. [Internet] [Thesis]. University of Saskatchewan; 2010. [cited 2020 Feb 23]. Available from: http://hdl.handle.net/10388/etd-01042010-110745.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Babcock KKR. The effects of anatomic resolution, respiratory variations and dose calculation methods on lung dosimetry. [Thesis]. University of Saskatchewan; 2010. Available from: http://hdl.handle.net/10388/etd-01042010-110745

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

29. Pomerenke, Anna Ewa. Investigating the immune responses of COPD lung tissue explants to viral stimuli.

Degree: 2015, University of Manchester

URL: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:275700

► Rationale Chronic obstructive pulmonary disease (COPD) is one of the leading causes of deaths worldwide. Patients with COPD have episodes of aggravated symptoms called exacerbations… (more)

▼ Rationale Chronic obstructive pulmonary disease (COPD) is one of the leading causes of deaths worldwide. Patients with COPD have episodes of aggravated symptoms called exacerbations caused by pathogens or pollution. Respiratory viruses are associated with a significant number of COPD exacerbations with the most common virus being the rhinovirus (RV). The mechanisms by which RVs trigger COPD exacerbations are still unclear. Using human whole lung tissue explants (WTE), a novel model of RV-induced COPD exacerbations is proposed.Methods WTE from COPD patients and smokers were initially stimulated with TLR ligands that are known to activate the same receptors as RV: poly(I:C) for TLR3 and R848 for TLR7/8 activation. Pro-inflammatory cytokines and type I and III IFN gene expression was measured by ELISA and qRT-PCR, respectively. A neutralising antibody against TNFα, a corticosteroid, and a panel of inhibitors targeting TLR pathway (p38 MAPK, IKK-2 and IRAK1/4) was applied to the tissue from COPD patients to establish which signalling pathways are responsible for the inflammatory response and IFN release. Explants from COPD patients and smokers was also exposed to two RV serotypes, RV-16 and RV-1B, in order to compare findings with a clinically relevant stimulant. Results Poly(I:C) and R848 caused a significant increase of protein and gene expression of pro-inflammatory cytokines (TNFα, CCL5 and IL-6). Type I and III IFN gene expression was also significantly increased. Using the two ligands together caused a synergistic release of TNFα and CCL5. Tissue from COPD patients released more pro-inflammatory cytokines and expressed less IFNβ when compared to smokers. TNFα neutralisation inhibited subsequent release of CCL5 and IL-6. Dexamethasone and p38 MAPK inhibitor decreased TLR3- and TLR7/8-induced pro-inflammatory response whereas IKK-2 and IRAK1/4 inhibition had little effect on cytokine release. Dexamethasone and IKK-2 showed limited effect on IFN gene expression whereas p38 MAPK inhibitor significantly decreased and IRAK1/4 inhibition enhanced IFN expression. RV-16 induced modest but significant pro-inflammatory response in lung tissue, whereas RV-1B did not induce cytokine release. Both serotypes induced type I and III IFN gene expression. Tissue from COPD patients showed a lower expression of IFNβ and IFNλ when compared to smokers.Conclusion This tissue explant was responsive to both synthetic TLR ligands and RV. The release of pro-inflammatory cytokines in response to TLR stimulation was partially inhibited by steroid. p38 MAPK is involved in TLR-induced inflammation but it also further decreases the already impaired IFN gene expression in COPD tissue. The role of IKK-2 and IRAK1/4 in TLR-induced innate immune response remains unclear. This model is a valuable system to study the mechanisms underlying RV-induced COPD exacerbations and also to test new inhibitors in the whole tissue environment. Advisors/Committee Members: HERRICK, SARAH SE, LINDSAY, MARK MA, Herrick, Sarah, Lindsay, Mark, Singh, Sukh.

Subjects/Keywords: COPD; Lung tissue; Rhinovirus; TLR

11 more images…

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Pomerenke, A. E. (2015). Investigating the immune responses of COPD lung tissue explants to viral stimuli. (Doctoral Dissertation). University of Manchester. Retrieved from http://www.manchester.ac.uk/escholar/uk-ac-man-scw:275700

Chicago Manual of Style (16^th Edition):

Pomerenke, Anna Ewa. “Investigating the immune responses of COPD lung tissue explants to viral stimuli.” 2015. Doctoral Dissertation, University of Manchester. Accessed February 23, 2020. http://www.manchester.ac.uk/escholar/uk-ac-man-scw:275700.

MLA Handbook (7^th Edition):

Pomerenke, Anna Ewa. “Investigating the immune responses of COPD lung tissue explants to viral stimuli.” 2015. Web. 23 Feb 2020.

Vancouver:

Pomerenke AE. Investigating the immune responses of COPD lung tissue explants to viral stimuli. [Internet] [Doctoral dissertation]. University of Manchester; 2015. [cited 2020 Feb 23]. Available from: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:275700.

Council of Science Editors:

Pomerenke AE. Investigating the immune responses of COPD lung tissue explants to viral stimuli. [Doctoral Dissertation]. University of Manchester; 2015. Available from: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:275700

University of Edinburgh

30. Glendinning, Laura. Sheep lung microbiota.

Degree: PhD, 2017, University of Edinburgh

URL: http://hdl.handle.net/1842/29541

► Until recently it was assumed that the healthy mammalian lung did not harbour a microbiota, unlike other body sites. However, through the use of sequencing… (more)

▼ Until recently it was assumed that the healthy mammalian lung did not harbour a microbiota, unlike other body sites. However, through the use of sequencing based technologies this has been shown to not be the case. Low biomass communities of microbes can be identified in the healthy lung and the lung microbiota in various diseases states has been shown to differ form these 'healthy' communities. The sheep respiratory microbiota is of interest from both an animal health perspective and due to the potential use of the sheep as a large animal model for studying the lung microbiota. In this thesis I seek to characterise the composition and variability of the sheep lung microbiota; the differences between the sheep upper and lower respiratory tract bacterial communities and to assess whether exhaled breath condensate collection can be used as a non-invasive lung microbiota sampling method. To study the bacterial communities present in samples I have used 16S rRNA gene sequencing and analysis. In Chapter 3 I examine the inter-individual and spatial variability present within the sheep lung microbiota. Protected specimen brushings were collected from three lung segments in six animals at three time-points. In a separate sheep a greater number of brushings was taken (n=16) in order to examine the amount of variability over a smaller spatial scale. I find that there can be large differences between the bacterial communities isolated from different locations within the lung, even over short distances. Samples also cluster by the sheep from which they were taken, indicating a host specific influence on the lung microbiota. In Chapter 4 I compare whole lung washes and oropharyngeal swabs from 40 lambs in order to examine the differences between the upper and lower respiratory tract microbiotas. I find that oropharyngeal swabs separate into rumen-like or upper respiratory tract-like bacterial communities. Despite the fact that in humans the upper and lower respiratory microbiotas have been shown to have similar compositions, the sheep lung microbiota samples in this study do not resemble either oropharyngeal samples or reagent only controls. In my first two results chapters, lung sampling methods were used which involved either anaesthesia combined with a bronchoscopic procedure (Chapter 3) or samples being taken from dead animals (Chapter 4). In Chapter 5 I assess whether there is a less invasive way of taking lung microbiota samples from a living individual, both to minimise the procedural stress on animals used as models and to increase the pool of potential volunteers for human lung microbiota studies. I compared samples taken via protected specimen brushings to samples taken via exhaled breath condensate collection, a less invasive sampling technique. I find that condensate samples contain less bacterial DNA and different bacteria than brushing samples, indicating that it is unlikely they could be used as a replacement for invasive sampling methods. In my final results chapter I compare the results across Chapters 3, 4 and 5…

Subjects/Keywords: lung microbiota; sheep microbiota; 16S

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Glendinning, L. (2017). Sheep lung microbiota. (Doctoral Dissertation). University of Edinburgh. Retrieved from http://hdl.handle.net/1842/29541

Chicago Manual of Style (16^th Edition):

Glendinning, Laura. “Sheep lung microbiota.” 2017. Doctoral Dissertation, University of Edinburgh. Accessed February 23, 2020. http://hdl.handle.net/1842/29541.

MLA Handbook (7^th Edition):

Glendinning, Laura. “Sheep lung microbiota.” 2017. Web. 23 Feb 2020.

Vancouver:

Glendinning L. Sheep lung microbiota. [Internet] [Doctoral dissertation]. University of Edinburgh; 2017. [cited 2020 Feb 23]. Available from: http://hdl.handle.net/1842/29541.

Council of Science Editors:

Glendinning L. Sheep lung microbiota. [Doctoral Dissertation]. University of Edinburgh; 2017. Available from: http://hdl.handle.net/1842/29541

		in
And / Or
		in
And / Or
		in
And / Or
		in

Open Access Theses and Dissertations