subject:(Lung)

University of Cape Town

1. Oosthuizen, Sarel Francois. A Radiological study of the Right Lung.

Degree: Doctoral, Medicine, 1943, University of Cape Town

URL: http://hdl.handle.net/11427/31911

The purpose of this thesis is to illustrate the author's observations on radiological investigations of the right lung both in the living body and at post-mortem, and to describe certain aspects of anatomical, clinical, pathological and radiological interest.

Subjects/Keywords: Lung

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APA (6^th Edition):

Oosthuizen, S. F. (1943). A Radiological study of the Right Lung. (Doctoral Dissertation). University of Cape Town. Retrieved from http://hdl.handle.net/11427/31911

Chicago Manual of Style (16^th Edition):

Oosthuizen, Sarel Francois. “A Radiological study of the Right Lung.” 1943. Doctoral Dissertation, University of Cape Town. Accessed February 26, 2021. http://hdl.handle.net/11427/31911.

MLA Handbook (7^th Edition):

Oosthuizen, Sarel Francois. “A Radiological study of the Right Lung.” 1943. Web. 26 Feb 2021.

Vancouver:

Oosthuizen SF. A Radiological study of the Right Lung. [Internet] [Doctoral dissertation]. University of Cape Town; 1943. [cited 2021 Feb 26]. Available from: http://hdl.handle.net/11427/31911.

Council of Science Editors:

Oosthuizen SF. A Radiological study of the Right Lung. [Doctoral Dissertation]. University of Cape Town; 1943. Available from: http://hdl.handle.net/11427/31911

Universidad de Cantabria

2. Duerto Álvarez, Jorge. Efecto a largo plazo en los injertos renales de un protocolo de manejo intensivo del donante multiorgánico.

Degree: 2016, Universidad de Cantabria

URL: http://hdl.handle.net/10902/9627

► La escasez de órganos disponibles para trasplante es la principal limitación en el desarrollo de esta terapia. Esto es especialmente acusado en el trasplante pulmonar,… (more)

Subjects/Keywords: Lung donor

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APA (6^th Edition):

Duerto Álvarez, J. (2016). Efecto a largo plazo en los injertos renales de un protocolo de manejo intensivo del donante multiorgánico. (Doctoral Dissertation). Universidad de Cantabria. Retrieved from http://hdl.handle.net/10902/9627

Chicago Manual of Style (16^th Edition):

Duerto Álvarez, Jorge. “Efecto a largo plazo en los injertos renales de un protocolo de manejo intensivo del donante multiorgánico.” 2016. Doctoral Dissertation, Universidad de Cantabria. Accessed February 26, 2021. http://hdl.handle.net/10902/9627.

MLA Handbook (7^th Edition):

Duerto Álvarez, Jorge. “Efecto a largo plazo en los injertos renales de un protocolo de manejo intensivo del donante multiorgánico.” 2016. Web. 26 Feb 2021.

Vancouver:

Duerto Álvarez J. Efecto a largo plazo en los injertos renales de un protocolo de manejo intensivo del donante multiorgánico. [Internet] [Doctoral dissertation]. Universidad de Cantabria; 2016. [cited 2021 Feb 26]. Available from: http://hdl.handle.net/10902/9627.

Council of Science Editors:

Duerto Álvarez J. Efecto a largo plazo en los injertos renales de un protocolo de manejo intensivo del donante multiorgánico. [Doctoral Dissertation]. Universidad de Cantabria; 2016. Available from: http://hdl.handle.net/10902/9627

Oklahoma State University

3. Wang, Yang. Functions of Micrornas in Lung Injury and Development.

Degree: Veterinary Pathobiology, 2011, Oklahoma State University

URL: http://hdl.handle.net/11244/7677

► The purpose of this study is to figure out what are the functions of microRNAs in lung development and injury. First, a microRNA microarray was… (more)

Subjects/Keywords: lung; microrna

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APA (6^th Edition):

Wang, Y. (2011). Functions of Micrornas in Lung Injury and Development. (Thesis). Oklahoma State University. Retrieved from http://hdl.handle.net/11244/7677

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Wang, Yang. “Functions of Micrornas in Lung Injury and Development.” 2011. Thesis, Oklahoma State University. Accessed February 26, 2021. http://hdl.handle.net/11244/7677.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Wang, Yang. “Functions of Micrornas in Lung Injury and Development.” 2011. Web. 26 Feb 2021.

Vancouver:

Wang Y. Functions of Micrornas in Lung Injury and Development. [Internet] [Thesis]. Oklahoma State University; 2011. [cited 2021 Feb 26]. Available from: http://hdl.handle.net/11244/7677.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Wang Y. Functions of Micrornas in Lung Injury and Development. [Thesis]. Oklahoma State University; 2011. Available from: http://hdl.handle.net/11244/7677

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

4. Sinzala, Martha. Prevalence and factors associated with acute occupational lung disease among Cotton Ginnery workers in Katete District.

Degree: 2014, University of Zimbabwe

URL: http://dspace.unza.zm/handle/123456789/3206

► The presence of byssinosis among workers in cotton ginneries has been well documented in studies from several countries.However, no studies had been performed among cotton… (more)

▼ The presence of byssinosis among workers in cotton ginneries has been well documented in studies from several countries.However, no studies had been performed among cotton workers in the Eastern Province of Zambia. In view of this, a cross sectional study design with 151 sample elements, drawn from Dunavant Ginnery in Katete, was employed. The main purpose of the study was to find out the prevalence of byssinosis among cotton ginnery workers. A survey questionnaire and lung function tests were conducted by a trained technician using a spirobank G spirometer. At the time of the study, the workers were employed in five departments and just about half n= 77 (51.1%) were involved in carding with 48.1% involved in other jobs. The longest a worker had served the company was 180 months or fifteen years and the least was barely one month.Out of the 151 workers, only 50 workers (33.1%) did not experience any symptoms of byssinosis. A greater number suffered from chest tightness and/or shortness of breath on most of first days back at work and on the first and other days of the working week. However, 76 (50.6%) of the workers showed a reduction in one symptom over the weekends and an increase in another within the week. Using the generally accepted World Health Organisation (WHO) (1983) criteria, this study found evidence for byssinosis among cotton workers with the highest prevalence of among those who at the time of the study had been engaged in carding, blending, and cleaning processes. The prevalence of byssinosis among cotton workers was 67%. Lung functional tests showed a peculiar trend of decline from day one today four in this sample under study. Of the four lung function tests, Forced Expiratory Volume per second (FEVs) and Forced Vital Capacity (FVC) showed more consistent reduction changes. However, all lung function tests were not significantly associated with work induced byssinotic symptoms. It can, therefore, be concluded on the basis of the study that byssinosis occurs in cotton workers particularly in those who are exposed to high concentrations of dust for a longer period especially in unmanaged and unprotected working environments. The study recommends the provision of protective clothing, environmental hygiene and periodic medical examination at two yearly intervals to identify those who ultimately will have to leave the industry because of progressive symptoms.

Subjects/Keywords: Lung Disease; Respiratory Distress; Lung Diseases

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APA (6^th Edition):

Sinzala, M. (2014). Prevalence and factors associated with acute occupational lung disease among Cotton Ginnery workers in Katete District. (Thesis). University of Zimbabwe. Retrieved from http://dspace.unza.zm/handle/123456789/3206

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Sinzala, Martha. “Prevalence and factors associated with acute occupational lung disease among Cotton Ginnery workers in Katete District.” 2014. Thesis, University of Zimbabwe. Accessed February 26, 2021. http://dspace.unza.zm/handle/123456789/3206.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Sinzala, Martha. “Prevalence and factors associated with acute occupational lung disease among Cotton Ginnery workers in Katete District.” 2014. Web. 26 Feb 2021.

Vancouver:

Sinzala M. Prevalence and factors associated with acute occupational lung disease among Cotton Ginnery workers in Katete District. [Internet] [Thesis]. University of Zimbabwe; 2014. [cited 2021 Feb 26]. Available from: http://dspace.unza.zm/handle/123456789/3206.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Sinzala M. Prevalence and factors associated with acute occupational lung disease among Cotton Ginnery workers in Katete District. [Thesis]. University of Zimbabwe; 2014. Available from: http://dspace.unza.zm/handle/123456789/3206

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

5. Wang, Zihao. Conceptualization and design of a future chest drainage canister.

Degree: Umeå Institute of Design, 2016, Umeå University

URL: http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-125683

► Changsha city in Hunan province, China. Place: Changsha Center Hospital, Hunan province. City Area: 11,819 square kilometers City population: 714.66 million I watched the… (more)

Subjects/Keywords: Damaged lung; chest drainage system; collapsed lung

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APA (6^th Edition):

Wang, Z. (2016). Conceptualization and design of a future chest drainage canister. (Thesis). Umeå University. Retrieved from http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-125683

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Wang, Zihao. “Conceptualization and design of a future chest drainage canister.” 2016. Thesis, Umeå University. Accessed February 26, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-125683.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Wang, Zihao. “Conceptualization and design of a future chest drainage canister.” 2016. Web. 26 Feb 2021.

Vancouver:

Wang Z. Conceptualization and design of a future chest drainage canister. [Internet] [Thesis]. Umeå University; 2016. [cited 2021 Feb 26]. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-125683.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Wang Z. Conceptualization and design of a future chest drainage canister. [Thesis]. Umeå University; 2016. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-125683

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Southern California

6. Selamat, Suhaida Adura. DNA methylation changes in the development of lung adenocarcinoma.

Degree: PhD, Genetic, Molecular and Cellular Biology, 2012, University of Southern California

URL: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/2645/rec/2069

► Lung cancer accounted for 13% of total cancer cases and 18% of cancer deaths globally in 2008. The combination of increasing smoking prevalence in many… (more)

Subjects/Keywords: DNA methylation; lung adenocarcinoma; lung cancer; epigenetics

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APA (6^th Edition):

Selamat, S. A. (2012). DNA methylation changes in the development of lung adenocarcinoma. (Doctoral Dissertation). University of Southern California. Retrieved from http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/2645/rec/2069

Chicago Manual of Style (16^th Edition):

Selamat, Suhaida Adura. “DNA methylation changes in the development of lung adenocarcinoma.” 2012. Doctoral Dissertation, University of Southern California. Accessed February 26, 2021. http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/2645/rec/2069.

MLA Handbook (7^th Edition):

Selamat, Suhaida Adura. “DNA methylation changes in the development of lung adenocarcinoma.” 2012. Web. 26 Feb 2021.

Vancouver:

Selamat SA. DNA methylation changes in the development of lung adenocarcinoma. [Internet] [Doctoral dissertation]. University of Southern California; 2012. [cited 2021 Feb 26]. Available from: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/2645/rec/2069.

Council of Science Editors:

Selamat SA. DNA methylation changes in the development of lung adenocarcinoma. [Doctoral Dissertation]. University of Southern California; 2012. Available from: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/2645/rec/2069

Temple University

7. Stabler, Collin Turner. Optimizing Endothelial Repopulation of Decellularized Lung.

Degree: PhD, 2016, Temple University

URL: http://digital.library.temple.edu/u?/p245801coll10,388434

►

Bioengineering

Decellularized lung tissue has been recognized as a potential platform to engineer whole lung organs suitable for transplantation or for modeling a variety of… (more)

▼

Bioengineering

Decellularized lung tissue has been recognized as a potential platform to engineer whole lung organs suitable for transplantation or for modeling a variety of lung diseases. However many technical hurdles remain before this potential may be fully realized. Inability to efficiently re-endothelialize the pulmonary vasculature with a functional endothelium appears to be the primary cause of failure of recellularized lung scaffolds in early transplant studies. This dissertation research aims to enhance the re-endothelialization of decellularized rodent lung scaffolds with rat lung microvascular endothelial cells. This was achieved by adjusting the posture of the lung to a supine position during cell seeding through the pulmonary artery. The supine position allowed for significantly more homogeneous seeding and better cell retention in the apex regions of all lobes than the traditional upright position, especially in the right upper and left lobes. Additionally, the supine position allowed for greater cell retention within large diameter vessels (proximal – 100 µm to 5,000 µm) than the upright position, with little to no difference in the small diameter distal vessels. Endothelial cell adhesion in the proximal regions of the pulmonary vasculature in the decellularized lung was dependent on the binding of endothelial cell integrins, specifically α1β1, α2β1 and α5β1 integrins to, respectively, collagen type-I, type-IV and fibronectin in the residual ECM. Following in vitro maturation of the seeded constructs under perfusion culture, the seeded endothelial cells spread along the vascular wall, leading to a partial re-establishment of endothelial barrier function as inferred from a custom-designed leakage assay. The results of this dissertation research suggest that attention to cellular distribution within the whole organ is of paramount importance for restoring proper vascular function.

Temple University – Theses

Advisors/Committee Members: Lelkes, Peter I.;, Pleshko, Nancy, Marcinkiewicz, Cezary, Wolfson, Marla R., Schulman, Edward S.;.

Subjects/Keywords: Biomedical engineering;

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APA (6^th Edition):

Stabler, C. T. (2016). Optimizing Endothelial Repopulation of Decellularized Lung. (Doctoral Dissertation). Temple University. Retrieved from http://digital.library.temple.edu/u?/p245801coll10,388434

Chicago Manual of Style (16^th Edition):

Stabler, Collin Turner. “Optimizing Endothelial Repopulation of Decellularized Lung.” 2016. Doctoral Dissertation, Temple University. Accessed February 26, 2021. http://digital.library.temple.edu/u?/p245801coll10,388434.

MLA Handbook (7^th Edition):

Stabler, Collin Turner. “Optimizing Endothelial Repopulation of Decellularized Lung.” 2016. Web. 26 Feb 2021.

Vancouver:

Stabler CT. Optimizing Endothelial Repopulation of Decellularized Lung. [Internet] [Doctoral dissertation]. Temple University; 2016. [cited 2021 Feb 26]. Available from: http://digital.library.temple.edu/u?/p245801coll10,388434.

Council of Science Editors:

Stabler CT. Optimizing Endothelial Repopulation of Decellularized Lung. [Doctoral Dissertation]. Temple University; 2016. Available from: http://digital.library.temple.edu/u?/p245801coll10,388434

Harvard University

8. Li, Richard. Venous Thromboembolism Risk in Patients With Locally Advanced Non-Small Cell Lung Cancer.

Degree: Doctor of Medicine, 2016, Harvard University

URL: http://nrs.harvard.edu/urn-3:HUL.InstRepos:40620276

►

Background: Patients with non-small cell lung cancer (NSCLC) are known to be at high risk for venous thromboembolism (VTE), but previous studies have not specifically… (more)

Subjects/Keywords: lung cancer; thromboembolism

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APA (6^th Edition):

Li, R. (2016). Venous Thromboembolism Risk in Patients With Locally Advanced Non-Small Cell Lung Cancer. (Doctoral Dissertation). Harvard University. Retrieved from http://nrs.harvard.edu/urn-3:HUL.InstRepos:40620276

Chicago Manual of Style (16^th Edition):

Li, Richard. “Venous Thromboembolism Risk in Patients With Locally Advanced Non-Small Cell Lung Cancer.” 2016. Doctoral Dissertation, Harvard University. Accessed February 26, 2021. http://nrs.harvard.edu/urn-3:HUL.InstRepos:40620276.

MLA Handbook (7^th Edition):

Li, Richard. “Venous Thromboembolism Risk in Patients With Locally Advanced Non-Small Cell Lung Cancer.” 2016. Web. 26 Feb 2021.

Vancouver:

Li R. Venous Thromboembolism Risk in Patients With Locally Advanced Non-Small Cell Lung Cancer. [Internet] [Doctoral dissertation]. Harvard University; 2016. [cited 2021 Feb 26]. Available from: http://nrs.harvard.edu/urn-3:HUL.InstRepos:40620276.

Council of Science Editors:

Li R. Venous Thromboembolism Risk in Patients With Locally Advanced Non-Small Cell Lung Cancer. [Doctoral Dissertation]. Harvard University; 2016. Available from: http://nrs.harvard.edu/urn-3:HUL.InstRepos:40620276

University of Dundee

9. Robertson, Holly. Mechanisms of repression of the transcription factor NRF2 by KEAP1- and B-TrCP-dependent ubiquitin ligases and how the dysregulation of NRF2 contributes to lung cancer progression.

Degree: PhD, 2019, University of Dundee

URL: https://discovery.dundee.ac.uk/en/studentTheses/4a7f87db-89f1-4bc4-b273-1bd7eb72ab0e ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.775364

► Lung cancer is the leading cause of cancer related mortality worldwide and since the discovery of the important role that NRF2 plays in regulating the… (more)

▼ Lung cancer is the leading cause of cancer related mortality worldwide and since the discovery of the important role that NRF2 plays in regulating the expression of phase II drug metabolism genes, NRF2 has been a highly studied therapeutic target. NRF2 signalling is often elevated in lung cancer due to mutations in NFE2L2, the gene that encodes NRF2; and KEAP1, the cytoplasmic regulator of NRF2. Since it became established that elevated NRF2 signalling provides a beneficial role to the tumour through enhancing proliferation, enabling survival in highly oxidative conditions and enhancing resistance to chemotherapeutic drugs; many groups have focussed on understanding KEAP1-independent forms of NRF2 regulation. It is now widely accepted that GSK-3 phosphorylation of the Neh6 domain of NRF2 is fundamental for SCFβ-TrCP-mediated degradation of the transcription factor. Previous work by other groups has indicated a potential role for a priming kinase to pre-phosphorylate the Neh6 domain and subsequently enhance GSK-3 mediated phosphorylation and resulting 26S proteasomal degradation. In the first results chapter of this thesis it was demonstrated using the DYRK family of isoenzymes that the presence of a priming kinase enhances GSK-3 phosphorylation and stimulates NRF2 degradation. Also, it has been shown that DYRK family members carry out priming of NRF2 through phosphorylating Ser-347, which enhances subsequent phosphorylation of Ser-342 and Ser-338 by GSK-3; regulating both NRF2 activity and stability. Additionally, it was shown that altering the phosphorylation status of Ser-347 impacts cell proliferation and chemo-sensitivity to platinum-based compounds. The ability of other kinases to phosphorylate the Neh6 domain was also revealed. In the second results chapter of this thesis a bioinformatics style approach was utilized to analyse the impact of mutations in KEAP1, NFE2L2 and CUL3; in terms of their effect on NRF2 activity using the expression of NRF2-target genes as a read out. The following points were highlighted from this analysis; (1) KEAP1 mutations are more prevalent than NFE2L2 and CUL3 mutations in both lung cancer cell lines and tumours; (2) KEAP1 and NFE2L2 mutations vary in there associated zygosity's, with KEAP1 mutations being predominantly homozygous and NFE2L2 mutations being predominantly heterozygous; (3) mutations in KEAP1 coexist with mutations in KRAS whereas, mutations in NFE2L2 co-exist with mutations in TP53 and (4) lung cancer cell lines and tumours harbouring mutations in KEAP1 have greater expression of NRF2-target genes than those harbouring either NFE2L2 or CUL3 mutations. In the third and final results chapter, both a panel of commercial cell lines and an in-house generated CRISPR/Cas9 panel of cell lines have been shown in multiple experiments to validate the bioinformatics findings of the previous chapter. Also, in this chapter it was identified that KEAP1 mutant cells are more reliant on the glutathione biosynthesis pathway for survival and therefore more sensitive to alterations in…

Subjects/Keywords: NRF2; Lung Cancer

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APA (6^th Edition):

Robertson, H. (2019). Mechanisms of repression of the transcription factor NRF2 by KEAP1- and B-TrCP-dependent ubiquitin ligases and how the dysregulation of NRF2 contributes to lung cancer progression. (Doctoral Dissertation). University of Dundee. Retrieved from https://discovery.dundee.ac.uk/en/studentTheses/4a7f87db-89f1-4bc4-b273-1bd7eb72ab0e ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.775364

Chicago Manual of Style (16^th Edition):

Robertson, Holly. “Mechanisms of repression of the transcription factor NRF2 by KEAP1- and B-TrCP-dependent ubiquitin ligases and how the dysregulation of NRF2 contributes to lung cancer progression.” 2019. Doctoral Dissertation, University of Dundee. Accessed February 26, 2021. https://discovery.dundee.ac.uk/en/studentTheses/4a7f87db-89f1-4bc4-b273-1bd7eb72ab0e ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.775364.

MLA Handbook (7^th Edition):

Robertson, Holly. “Mechanisms of repression of the transcription factor NRF2 by KEAP1- and B-TrCP-dependent ubiquitin ligases and how the dysregulation of NRF2 contributes to lung cancer progression.” 2019. Web. 26 Feb 2021.

Vancouver:

Robertson H. Mechanisms of repression of the transcription factor NRF2 by KEAP1- and B-TrCP-dependent ubiquitin ligases and how the dysregulation of NRF2 contributes to lung cancer progression. [Internet] [Doctoral dissertation]. University of Dundee; 2019. [cited 2021 Feb 26]. Available from: https://discovery.dundee.ac.uk/en/studentTheses/4a7f87db-89f1-4bc4-b273-1bd7eb72ab0e ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.775364.

Council of Science Editors:

Robertson H. Mechanisms of repression of the transcription factor NRF2 by KEAP1- and B-TrCP-dependent ubiquitin ligases and how the dysregulation of NRF2 contributes to lung cancer progression. [Doctoral Dissertation]. University of Dundee; 2019. Available from: https://discovery.dundee.ac.uk/en/studentTheses/4a7f87db-89f1-4bc4-b273-1bd7eb72ab0e ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.775364

University of New South Wales

10. Wong, Sze Wing (Alice). Functions of S100A8 in lung cancer.

Degree: Medical Sciences, 2018, University of New South Wales

URL: http://handle.unsw.edu.au/1959.4/60230 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:51254/SOURCE02?view=true

► S100A8 is an anti-inflammatory oxidant scavenger protein that induces IL-10 in airway epithelial cells in normal lungs following inhalation. These mechanisms contribute to its ability… (more)

Subjects/Keywords: Lung cancer; S100A8

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APA (6^th Edition):

Wong, S. W. (. (2018). Functions of S100A8 in lung cancer. (Doctoral Dissertation). University of New South Wales. Retrieved from http://handle.unsw.edu.au/1959.4/60230 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:51254/SOURCE02?view=true

Chicago Manual of Style (16^th Edition):

Wong, Sze Wing (Alice). “Functions of S100A8 in lung cancer.” 2018. Doctoral Dissertation, University of New South Wales. Accessed February 26, 2021. http://handle.unsw.edu.au/1959.4/60230 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:51254/SOURCE02?view=true.

MLA Handbook (7^th Edition):

Wong, Sze Wing (Alice). “Functions of S100A8 in lung cancer.” 2018. Web. 26 Feb 2021.

Vancouver:

Wong SW(. Functions of S100A8 in lung cancer. [Internet] [Doctoral dissertation]. University of New South Wales; 2018. [cited 2021 Feb 26]. Available from: http://handle.unsw.edu.au/1959.4/60230 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:51254/SOURCE02?view=true.

Council of Science Editors:

Wong SW(. Functions of S100A8 in lung cancer. [Doctoral Dissertation]. University of New South Wales; 2018. Available from: http://handle.unsw.edu.au/1959.4/60230 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:51254/SOURCE02?view=true

Dalhousie University

11. Leary, Del. MODELING OF SPATIAL AND TEMPORAL HETEROGENEITY OF THE HUMAN LUNG.

Degree: PhD, Department of Physics & Atmospheric Science, 2013, Dalhousie University

URL: http://hdl.handle.net/10222/36311

► This thesis investigates variability in airway caliber and the distribution of ventilation within the human lung as thought to occur in asthma. Currently, the understanding… (more)

▼ This thesis investigates variability in airway caliber and the distribution of ventilation within the human lung as thought to occur in asthma. Currently, the understanding of how an integrated network of airways can lead to temporal and spatial variation as found in the human lung is unclear. Throughout this thesis, a multibranch airway tree model was used in a forward modeling approach. In a variability study, the mean airway resistance (RL) was observed to be proportional to the standard deviation in airway resistance (SDRL) as reported in the literature under several conditions of airway diameter indicating the strong robustness of this behavior. The model predicted previously reported RL distributions and the reported proportionality of SDRL and RL, but only when we included coherency between airways. In a second study, patient specific ventilation was investigated using an image functional approach by closing specific airways (creating defects) identified by hyperpolarized 3He MRI from asthmatic subjects. Impedance predictions from the imposed heterogeneous ventilation were then calculated and correlated to 3He MRI ventilation defect percent (VDP), plethysmography, and spirometry data. These predictions suggest the forced oscillation technique (FOT) to be a superior metric toward the evaluation of the VDP. In a third study, we investigated how asymmetric branching could play a role in ventilation defect emergence and persistence. At high muscle activation levels simulating an asthmatic episode, airway trees with greater asymmetry reached steady state sooner, with defects that were more persistent in location, had lower RL values (~50%), and greater EL values (~25%) after bronchoconstriction. These results suggest the initial formation of ventilation defects was dependent on airway instability; however, the location and persistence of ventilation defects may be due to geometric airway structure. By modeling the contribution of ventilation defects to lung impedance, we were able to show that defects can play a role in governing the relationship between RL and its variation, and the effect of defects through VDP could be better assessed using FOT. Moreover, lung structure contributed to the emergence and persistence of ventilation defects, meaning that defects could be potentially ameliorated through structural intervention. Advisors/Committee Members: Jason Bates (external-examiner), Jordan Kyriakidis (graduate-coordinator), Steven Beyea, Grace Parraga, Andrew Rutenberg (thesis-reader), Geoff Maksym (thesis-supervisor), Not Applicable (ethics-approval), Yes (manuscripts), Yes (copyright-release).

Subjects/Keywords: lung modeling; temporal variability; spatial variability; human lung; lung mechanics

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APA (6^th Edition):

Leary, D. (2013). MODELING OF SPATIAL AND TEMPORAL HETEROGENEITY OF THE HUMAN LUNG. (Doctoral Dissertation). Dalhousie University. Retrieved from http://hdl.handle.net/10222/36311

Chicago Manual of Style (16^th Edition):

Leary, Del. “MODELING OF SPATIAL AND TEMPORAL HETEROGENEITY OF THE HUMAN LUNG.” 2013. Doctoral Dissertation, Dalhousie University. Accessed February 26, 2021. http://hdl.handle.net/10222/36311.

MLA Handbook (7^th Edition):

Leary, Del. “MODELING OF SPATIAL AND TEMPORAL HETEROGENEITY OF THE HUMAN LUNG.” 2013. Web. 26 Feb 2021.

Vancouver:

Leary D. MODELING OF SPATIAL AND TEMPORAL HETEROGENEITY OF THE HUMAN LUNG. [Internet] [Doctoral dissertation]. Dalhousie University; 2013. [cited 2021 Feb 26]. Available from: http://hdl.handle.net/10222/36311.

Council of Science Editors:

Leary D. MODELING OF SPATIAL AND TEMPORAL HETEROGENEITY OF THE HUMAN LUNG. [Doctoral Dissertation]. Dalhousie University; 2013. Available from: http://hdl.handle.net/10222/36311

University of Toronto

12. Reck dos Santos, Pedro Augusto. Development of In Vivo Lung Perfusion Strategy for the Treatment of Lung Metastases.

Degree: 2015, University of Toronto

URL: http://hdl.handle.net/1807/69694

►

In Vivo Lung Perfusion (IVLP) can potentially enhance the treatment of lung metastases by allowing the delivery of elevated doses of chemotherapy to the lungs… (more)

Subjects/Keywords: In Vivo Lung Perfusion; Isolated Lung Perfusion; Locoregional Therapy; Lung Metastases; Pulmonary Metastasectomy; Sarcomas; 0576

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APA (6^th Edition):

Reck dos Santos, P. A. (2015). Development of In Vivo Lung Perfusion Strategy for the Treatment of Lung Metastases. (Masters Thesis). University of Toronto. Retrieved from http://hdl.handle.net/1807/69694

Chicago Manual of Style (16^th Edition):

Reck dos Santos, Pedro Augusto. “Development of In Vivo Lung Perfusion Strategy for the Treatment of Lung Metastases.” 2015. Masters Thesis, University of Toronto. Accessed February 26, 2021. http://hdl.handle.net/1807/69694.

MLA Handbook (7^th Edition):

Reck dos Santos, Pedro Augusto. “Development of In Vivo Lung Perfusion Strategy for the Treatment of Lung Metastases.” 2015. Web. 26 Feb 2021.

Vancouver:

Reck dos Santos PA. Development of In Vivo Lung Perfusion Strategy for the Treatment of Lung Metastases. [Internet] [Masters thesis]. University of Toronto; 2015. [cited 2021 Feb 26]. Available from: http://hdl.handle.net/1807/69694.

Council of Science Editors:

Reck dos Santos PA. Development of In Vivo Lung Perfusion Strategy for the Treatment of Lung Metastases. [Masters Thesis]. University of Toronto; 2015. Available from: http://hdl.handle.net/1807/69694

University of Gothenburg / Göteborgs Universitet

13. Wallinder, Andreas. Ex Vivo Lung Perfusion - clinical and experimental studies.

Degree: 2014, University of Gothenburg / Göteborgs Universitet

URL: http://hdl.handle.net/2077/35943

► For patients who are suffering from end-stage lung disease, lung transplantation is a life-prolonging therapy. The number of donor lungs is limited and the majority… (more)

▼ For patients who are suffering from end-stage lung disease, lung transplantation is a life-prolonging therapy. The number of donor lungs is limited and the majority of available donor lungs, in some regions up to 85%, are discarded due to known or presumed organ dysfunction. Lung donations after cardiac death (DCD) and increased utilization of lungs from donations after brain death (DBD) could increase the availability of donor organs. Ex vivo lung perfusion (EVLP) is a method that has been developed for the preservation and evaluation of donor lungs during continuous perfusion and ventilation. EVLP is applicable to lungs harvested from DCD, as well as to the lungs of DBD with suboptimal lung function. Method: In Papers I and II, an uncontrolled DCD situation was simulated in a pig model. The currently suggested protocol for DCD lung procurement, involving post-mortem administration of heparin followed by chest compressions and intrapleural cooling of the lungs to 12°C, was compared to a simplified procurement method that does not use heparin and employs a less-invasive cooling technique. In Papers III–V, the methods and results for EVLP for the salvage of initially rejected human donor lungs were investigated. Rejected donor lungs with inferior function were retrieved and connected to the EVLP system. Assessments of lung function, with respect to circulatory and respiratory parameters, were performed. EVLP-treated lungs that were deemed to have normal function were transplanted into recipients from the conventional waiting list for transplantation. The short-term and long-term outcomes for the recipients of the EVLP-treated lungs were compared to a consecutive series of patients who received non- EVLP lungs prepared according to the standard protocol. Results: In Papers I and II, the lung function assessed during EVLP and at post-EVLP analyses in terms of the water content of lung tissues and markers of lung injury, did not differ significantly between the treatment and control groups. In Papers III–V, 25 pairs of rejected donor lungs underwent EVLP. Eighteen double lungs and four single lungs were transplanted after EVLP, and the recipients (EVLP group; N=22) were compared with recipients of conventionally prepared lungs (Control group; N=115). The median time to extubation (p=0.26) and the median stay in the intensive care unit (p=0.06) did not differ significantly for the two groups. Primary graft dysfunction higher than grade 1 was noted for 14% of the recipients in the EVLP group and 11% of the Control group at 72 hours post-transplantation. The cumulative 1-year survival rates were 89% for the EVLP group and 82% for the Control group. The cumulative survival rates for up to three years of follow-up were comparable for these two groups (p=0.67). Conclusion: Papers I and II provide support for the notion that a no-touch period of 1 hour after death in cases of uncontrolled DCD would not compromise donor lung function. This would allow the next-of-kin to spend time with the deceased and to facilitate the…

Subjects/Keywords: Lung transplantation; Ex vivo lung perfusion; Donation after cardiac death; Donor lung procurement

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APA (6^th Edition):

Wallinder, A. (2014). Ex Vivo Lung Perfusion - clinical and experimental studies. (Thesis). University of Gothenburg / Göteborgs Universitet. Retrieved from http://hdl.handle.net/2077/35943

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Wallinder, Andreas. “Ex Vivo Lung Perfusion - clinical and experimental studies.” 2014. Thesis, University of Gothenburg / Göteborgs Universitet. Accessed February 26, 2021. http://hdl.handle.net/2077/35943.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Wallinder, Andreas. “Ex Vivo Lung Perfusion - clinical and experimental studies.” 2014. Web. 26 Feb 2021.

Vancouver:

Wallinder A. Ex Vivo Lung Perfusion - clinical and experimental studies. [Internet] [Thesis]. University of Gothenburg / Göteborgs Universitet; 2014. [cited 2021 Feb 26]. Available from: http://hdl.handle.net/2077/35943.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Wallinder A. Ex Vivo Lung Perfusion - clinical and experimental studies. [Thesis]. University of Gothenburg / Göteborgs Universitet; 2014. Available from: http://hdl.handle.net/2077/35943

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universiteit Utrecht

14. Breeveld, A.R. Shape of the exposure response relation for crystalline silica and risk of lung cancer.

Degree: 2011, Universiteit Utrecht

URL: http://dspace.library.uu.nl:8080/handle/1874/209135

► Crystalline silica exposure mostly occurs in occupational settings such as mining, construction, several industries (e.g. foundries) and agriculture. Occupational exposure to silica dust is known… (more)

Subjects/Keywords: crystalline silica; lung cancer

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APA (6^th Edition):

Breeveld, A. R. (2011). Shape of the exposure response relation for crystalline silica and risk of lung cancer. (Masters Thesis). Universiteit Utrecht. Retrieved from http://dspace.library.uu.nl:8080/handle/1874/209135

Chicago Manual of Style (16^th Edition):

Breeveld, A R. “Shape of the exposure response relation for crystalline silica and risk of lung cancer.” 2011. Masters Thesis, Universiteit Utrecht. Accessed February 26, 2021. http://dspace.library.uu.nl:8080/handle/1874/209135.

MLA Handbook (7^th Edition):

Breeveld, A R. “Shape of the exposure response relation for crystalline silica and risk of lung cancer.” 2011. Web. 26 Feb 2021.

Vancouver:

Breeveld AR. Shape of the exposure response relation for crystalline silica and risk of lung cancer. [Internet] [Masters thesis]. Universiteit Utrecht; 2011. [cited 2021 Feb 26]. Available from: http://dspace.library.uu.nl:8080/handle/1874/209135.

Council of Science Editors:

Breeveld AR. Shape of the exposure response relation for crystalline silica and risk of lung cancer. [Masters Thesis]. Universiteit Utrecht; 2011. Available from: http://dspace.library.uu.nl:8080/handle/1874/209135

15. 坪内, 拡伸. Rikkunshito ameliorates bleomycin-induced acute lung injury in a ghrelin-independent manner : 六君子湯投与はブレオマイシン誘導性急性肺障害をグレリン非依存性に改善する.

Degree: 博士(医学), 2014, University of Miyazaki / 宮崎大学

URL: http://hdl.handle.net/10458/5039

以下に掲載:American Journal of Physiology - Lung Cellular and Molecular Physiology. 2014, 306, 3, p.L233-L245, doi:10.1152/ajplung.00096.2013.

Subjects/Keywords: rikkunshito; acute lung injury; ghrelin

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APA (6^th Edition):

坪内, �. (2014). Rikkunshito ameliorates bleomycin-induced acute lung injury in a ghrelin-independent manner : 六君子湯投与はブレオマイシン誘導性急性肺障害をグレリン非依存性に改善する. (Thesis). University of Miyazaki / 宮崎大学. Retrieved from http://hdl.handle.net/10458/5039

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

坪内, 拡伸. “Rikkunshito ameliorates bleomycin-induced acute lung injury in a ghrelin-independent manner : 六君子湯投与はブレオマイシン誘導性急性肺障害をグレリン非依存性に改善する.” 2014. Thesis, University of Miyazaki / 宮崎大学. Accessed February 26, 2021. http://hdl.handle.net/10458/5039.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

坪内, 拡伸. “Rikkunshito ameliorates bleomycin-induced acute lung injury in a ghrelin-independent manner : 六君子湯投与はブレオマイシン誘導性急性肺障害をグレリン非依存性に改善する.” 2014. Web. 26 Feb 2021.

Vancouver:

坪内 �. Rikkunshito ameliorates bleomycin-induced acute lung injury in a ghrelin-independent manner : 六君子湯投与はブレオマイシン誘導性急性肺障害をグレリン非依存性に改善する. [Internet] [Thesis]. University of Miyazaki / 宮崎大学; 2014. [cited 2021 Feb 26]. Available from: http://hdl.handle.net/10458/5039.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

坪内 �. Rikkunshito ameliorates bleomycin-induced acute lung injury in a ghrelin-independent manner : 六君子湯投与はブレオマイシン誘導性急性肺障害をグレリン非依存性に改善する. [Thesis]. University of Miyazaki / 宮崎大学; 2014. Available from: http://hdl.handle.net/10458/5039

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Alberta

16. Al-Hallak, MHD Kamal. Inhalable nanoparticles in lung cancer treatment; efficacy, safety, distribution and nanoparticle-macrophage interactions.

Degree: PhD, Faculty of Pharmacy and Pharmaceutical Sciences, 2012, University of Alberta

URL: https://era.library.ualberta.ca/files/mk61rj53p

► In 2002, lung cancer was responsible for 17.6% of the total worldwide deaths from cancer. Beyond the three traditional forms of cancer treatment, surgery, radiation… (more)

▼ In 2002, lung cancer was responsible for 17.6% of the total worldwide deaths from cancer. Beyond the three traditional forms of cancer treatment, surgery, radiation therapy, and chemotherapy, targeted drug delivery therapy has shown to be a potential treatment option. The design of a successful delivery system requires consideration of many factors, some of which include (i) the location and main organ(s) affected; (ii) the complexity of the associated physiological changes; (iii) the changes in receptor expression in cancerous cells; (iv) the physiochemical properties of the delivery system; (v) the interactions between the cancerous cells and other adjuvant cells, such as macrophages, with the delivery system; and (vi) the safety and tolerability of the delivery system. Considering the above factors of a successful delivery system, the aim of the present work was to design an innovative delivery system for lung cancer treatment incorporating inhalable nanoparticles (NP). To achieve this goal, several objectives were developed: (i) to investigate the interactions of different NP formulations with macrophages and the resulting effects on the behavior of macrophages; (ii) to assess and correlate the pulmonary toxicity of inhalable NPs using in vivo and in vitro methods; (iii) to develop a method to assess in real-time the effect of the formulation modifications on the uptake by macrophages of NPs; (iv) to assess the in vivo efficacy of an innovative formulation of effervescent inhalable NPs, thus actively releasing NPs; and finally, (v) to investigate the distribution of effervescent inhalable NPs after pulmonary delivery. Our results demonstrate that after exposure to NPs, macrophages undergo cellular changes to gain the ability to produce Th1 cytokines that are able to affect the viability of cancerous cells. The tolerability of inhalable NPs was related mainly to the additives used in the NP formulation. There was a good correlation between the in vivo and in vitro results. Effervescent inhalable NPs proved to be an effective and tolerable treatment for lung cancer treatment. Whole body autoradiography showed that inhalable NPs were able to achieve deep lung deposition and become distributed in time over the whole lung with some extra-pulmonary distribution.

Subjects/Keywords: inhalable nanoparticles; Lung cancer; Macrophages

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APA (6^th Edition):

Al-Hallak, M. K. (2012). Inhalable nanoparticles in lung cancer treatment; efficacy, safety, distribution and nanoparticle-macrophage interactions. (Doctoral Dissertation). University of Alberta. Retrieved from https://era.library.ualberta.ca/files/mk61rj53p

Chicago Manual of Style (16^th Edition):

Al-Hallak, MHD Kamal. “Inhalable nanoparticles in lung cancer treatment; efficacy, safety, distribution and nanoparticle-macrophage interactions.” 2012. Doctoral Dissertation, University of Alberta. Accessed February 26, 2021. https://era.library.ualberta.ca/files/mk61rj53p.

MLA Handbook (7^th Edition):

Al-Hallak, MHD Kamal. “Inhalable nanoparticles in lung cancer treatment; efficacy, safety, distribution and nanoparticle-macrophage interactions.” 2012. Web. 26 Feb 2021.

Vancouver:

Al-Hallak MK. Inhalable nanoparticles in lung cancer treatment; efficacy, safety, distribution and nanoparticle-macrophage interactions. [Internet] [Doctoral dissertation]. University of Alberta; 2012. [cited 2021 Feb 26]. Available from: https://era.library.ualberta.ca/files/mk61rj53p.

Council of Science Editors:

Al-Hallak MK. Inhalable nanoparticles in lung cancer treatment; efficacy, safety, distribution and nanoparticle-macrophage interactions. [Doctoral Dissertation]. University of Alberta; 2012. Available from: https://era.library.ualberta.ca/files/mk61rj53p

University of Alberta

17. Noice, Lori. A Quantitative Analysis of Four Dimensional Computed Tomography.

Degree: MS, Physics, 2010, University of Alberta

URL: https://era.library.ualberta.ca/files/0z708x912

► This project assesses the four dimensional computed tomography (4DCT) capabilities of the Philips Brilliance Big Bore CT scanner (Philips Medical Systems, Cleveland, OH). A mechanical… (more)

Subjects/Keywords: 4DCT, CT, lung, motion management

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APA (6^th Edition):

Noice, L. (2010). A Quantitative Analysis of Four Dimensional Computed Tomography. (Masters Thesis). University of Alberta. Retrieved from https://era.library.ualberta.ca/files/0z708x912

Chicago Manual of Style (16^th Edition):

Noice, Lori. “A Quantitative Analysis of Four Dimensional Computed Tomography.” 2010. Masters Thesis, University of Alberta. Accessed February 26, 2021. https://era.library.ualberta.ca/files/0z708x912.

MLA Handbook (7^th Edition):

Noice, Lori. “A Quantitative Analysis of Four Dimensional Computed Tomography.” 2010. Web. 26 Feb 2021.

Vancouver:

Noice L. A Quantitative Analysis of Four Dimensional Computed Tomography. [Internet] [Masters thesis]. University of Alberta; 2010. [cited 2021 Feb 26]. Available from: https://era.library.ualberta.ca/files/0z708x912.

Council of Science Editors:

Noice L. A Quantitative Analysis of Four Dimensional Computed Tomography. [Masters Thesis]. University of Alberta; 2010. Available from: https://era.library.ualberta.ca/files/0z708x912

Cornell University

18. Jirapatnakul, Artit. Computer Methods For Pulmonary Nodule Characterization From Ct Images.

Degree: M.S., Electrical Engineering, Electrical Engineering, 2011, Cornell University

URL: http://hdl.handle.net/1813/29192

► Computed tomography (CT) scans provide radiologists a non-invasive method of imaging internal structures of the body. Although CT scans have enabled the earlier detection of… (more)

▼ Computed tomography (CT) scans provide radiologists a non-invasive method of imaging internal structures of the body. Although CT scans have enabled the earlier detection of suspicious nodules, these nodules are often small and difficult to accurately classify for radiologists. An automated system was developed to classify a pulmonary nodule based on image features extracted from a single CT scan. Several critical issues related to performance evaluation of such systems were also examined. The image features considered in the system were: statistics from the density distribution, shape, curvature, and boundary features. The shape and density features were computed through moment analysis of the segmented nodule. Local curvature was computed from a triangle-tessellated surface of the nodule; the statistics of the distribution of curvatures were used as features in the system. Finally, the boundary of the nodule was examined to quantify the transition region between the nodule and lung parenchyma. This was accomplished by combining the grayscale information and 3D model to measure the gradient on the surface of the nodule. These methods resulted in a total of 43 features. For compari- son, 2D features were computed for the density and shape features, resulting in 26 features. Four feature classification schemes were evaluated: logistic regression, k-nearest-neighbors, distance-weighted nearest-neighbors, and support vector machines (SVM). These features and classifiers were validated on a large dataset of 259 nodules. The best performance, an area under the ROC curve (AUC) of 0.702, was achieved using 3D features and the logistic regression classifier. A major consideration when evaluating a nodule classification system is whether the system presents an improvement over a baseline performance. Since the majority of large nodules in many datasets are malignant, the impact of nodule size on the performance of the classification system was examined. This was accomplished by comparing the performance of the system with feature sets that included sizedependent features to feature sets that excluded those features.The performance of size alone, estimated using a size-threshold classifier, was an AUC of 0.653. For the SVM classifier, removing size-dependent features reduced the performance from an AUC of 0.69 to 0.61. To approximate the performance that might be obtained on a dataset without a size bias, a subset of cases was selected where the benign and malignant nodules were of similar sizes. On this subset, size was not a very powerful feature with an AUC of 0.507, and features that were not dependent on size performed better than size-dependent features for SVM, with an AUC of 0.63 compared to 0.52. While other methods have been proposed for performing nodule classification, this is the first study to comprehensively look at the performance impact from datasets with nodules that exhibit a bias in size. Advisors/Committee Members: Reeves, Anthony P (chair), Doerschuk, Peter (committee member).

Subjects/Keywords: pulmonary nodule; characterization; lung cancer

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APA (6^th Edition):

Jirapatnakul, A. (2011). Computer Methods For Pulmonary Nodule Characterization From Ct Images. (Masters Thesis). Cornell University. Retrieved from http://hdl.handle.net/1813/29192

Chicago Manual of Style (16^th Edition):

Jirapatnakul, Artit. “Computer Methods For Pulmonary Nodule Characterization From Ct Images.” 2011. Masters Thesis, Cornell University. Accessed February 26, 2021. http://hdl.handle.net/1813/29192.

MLA Handbook (7^th Edition):

Jirapatnakul, Artit. “Computer Methods For Pulmonary Nodule Characterization From Ct Images.” 2011. Web. 26 Feb 2021.

Vancouver:

Jirapatnakul A. Computer Methods For Pulmonary Nodule Characterization From Ct Images. [Internet] [Masters thesis]. Cornell University; 2011. [cited 2021 Feb 26]. Available from: http://hdl.handle.net/1813/29192.

Council of Science Editors:

Jirapatnakul A. Computer Methods For Pulmonary Nodule Characterization From Ct Images. [Masters Thesis]. Cornell University; 2011. Available from: http://hdl.handle.net/1813/29192

Cornell University

19. Tang, Wenbo. The Role Of Genetics, Nutrition, And Cigarette Smoking In The Longitudinal Change In Lung Function.

Degree: PhD, Nutrition, 2013, Cornell University

URL: http://hdl.handle.net/1813/34378

► Lung function is an important predictor of population morbidity and mortality. Decline in lung function is a natural part of aging, but accelerated loss in… (more)

▼ Lung function is an important predictor of population morbidity and mortality. Decline in lung function is a natural part of aging, but accelerated loss in lung function over time is a harbinger of chronic obstructive pulmonary disease (COPD), a leading cause of death globally. Smoking is widely recognized as the key risk factor for reduced lung function and COPD, although additional risk factors, such as genetics and nutrition, have been suggested to also play important roles in contributing to changes in lung function. The overall aim of this research was to investigate the role of, and interaction between, genetics, nutrition, and cigarette smoking in relation to the longitudinal change in lung function, as an indicator of COPD susceptibility. First, we explored the association between genetic variation within a network of antioxidant enzyme genes and the rate of change in lung function in a prospective cohort study of African and European American elderly adults; this study also investigated gene-bysmoking interaction. Evidence of association was identified for genetic variants in several candidate genes, among which were two novel genes (mGST3 and IDH3B) that interacted with smoking in both races/ethnicities. Second, to expand the scope of investigation to all common genetic variants iii throughout the entire human genome, we conducted a large-scale meta-analysis of genomewide association studies of longitudinal change in lung function in a consortium of 14 individual cohort studies of adults of European ancestry. We found evidence of association at two novel genetic loci (IL16/STARD5/TMC3 and ME3) in the meta-analysis and performed additional gene expression analyses to demonstrate that both loci harbor candidate genes with biologically plausible functional links to lung function. Finally, we explored the role of nutrition directly by investigating the relation between overall dietary patterns and longitudinal change in lung function in a prospective cohort of male adults, considering diet-by-smoking interaction. We identified two distinct dietary patterns by applying principal component analysis to food frequency questionnaire data, and found that a prudent diet rich in fruits, vegetables, fish, and poultry attenuated the accelerated decline in lung function in cigarette smokers, but had no association in non-smokers. iv Advisors/Committee Members: Cassano, Patricia Ann (chair), Wells, Martin Timothy (committee member), Clark, Andrew (committee member), Caudill, Marie A. (committee member).

Subjects/Keywords: Lung function; Genetics; Nutrition

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APA (6^th Edition):

Tang, W. (2013). The Role Of Genetics, Nutrition, And Cigarette Smoking In The Longitudinal Change In Lung Function. (Doctoral Dissertation). Cornell University. Retrieved from http://hdl.handle.net/1813/34378

Chicago Manual of Style (16^th Edition):

Tang, Wenbo. “The Role Of Genetics, Nutrition, And Cigarette Smoking In The Longitudinal Change In Lung Function.” 2013. Doctoral Dissertation, Cornell University. Accessed February 26, 2021. http://hdl.handle.net/1813/34378.

MLA Handbook (7^th Edition):

Tang, Wenbo. “The Role Of Genetics, Nutrition, And Cigarette Smoking In The Longitudinal Change In Lung Function.” 2013. Web. 26 Feb 2021.

Vancouver:

Tang W. The Role Of Genetics, Nutrition, And Cigarette Smoking In The Longitudinal Change In Lung Function. [Internet] [Doctoral dissertation]. Cornell University; 2013. [cited 2021 Feb 26]. Available from: http://hdl.handle.net/1813/34378.

Council of Science Editors:

Tang W. The Role Of Genetics, Nutrition, And Cigarette Smoking In The Longitudinal Change In Lung Function. [Doctoral Dissertation]. Cornell University; 2013. Available from: http://hdl.handle.net/1813/34378

Vanderbilt University

20. Samanta, Debangshu. Long-term smoking-mediated downregulation of Smad3 induces tumorigenicity and carboplatin resistance in non-small cell lung cancer.

Degree: PhD, Cancer Biology, 2012, Vanderbilt University

URL: http://hdl.handle.net/1803/12131

► Inactivating mutations in TGF-©¬ receptors and Smad signal transducers that contribute to resistance to TGF-©¬, are associated with only very small number of NSCLC. The… (more)

▼ Inactivating mutations in TGF-©¬ receptors and Smad signal transducers that contribute to resistance to TGF-©¬, are associated with only very small number of NSCLC. The Smad dependent pathway is involved in the tumor suppressive functions of TGF-¥â. Epidemiological studies have demonstrated that most cases of lung cancer (85-90%) are directly attributable to cigarette smoking. However, nothing is known how smoking is involved in inhibiting tumor suppressor functions of TGF-©¬ and whether or how the chemo resistance of platinum-based drugs seen in lung cancer patients who are smokers is dependent on this pathway. To address this issue, lung adenocarcinoma A549 and immortalized bronchial epithelial HPL1A cells were chronically treated (300 days) with cigarette smoke condensate (CSC) and Dimethyl sulphoxide (DMSO, as a control) to mimic the conditions of long-term cigarette smoking. Prolonged exposure of these cells to CSC resulted in decreased Smad-mediated TGF-¥â signaling due to reduced expression of Smad3 both in the protein and mRNA level. The decrease in Smad3 is due to histone deacetylation. Long-term CSC treatment reduced apoptosis, increased cell viability, decreased TGF-¥â-mediated growth inhibition, and enhanced tumorigenicity both in vitro and in vivo. Re-expression of Smad3 in the long-term CSC treated cells reversed the cancerous phenotypes observed due to long-term CSC treatment. Looking further into public databases revealed that the expression of Smad3 is lower in lung tumors of current smokers compared to that observed in never-smokers. The long-term CSC treatment also rendered the cells resistant to platinum-based chemotherapy; by up regulating Bcl2. Blocking the effect of Bcl2 both by small molecule inhibitor ABT-737 and siRNA approaches re-sensitized the cells to platinum-based chemotherapy. The re-expression of exogenous Smad3 in the long-term CSC treated cells, decreased the Bcl2 levels and re-sensitized the cells to platinum-based chemotherapy. Thus, Smad3 controls the expression of Bcl2 and sensitivity to platinum based drugs in our model system. Collectively, these data provide evidence that cigarette smoking promotes tumorigenicity and makes the cells resistant to platinum-based chemotherapy by abrogating apoptosis, partly by reducing expression of Smad3. Advisors/Committee Members: Pran K. Datta (committee member), Mark deCaestecker (committee member), Lawrence J. Marnett (committee member), David P. Carbone (committee member), Jin Chen (Committee Chair).

Subjects/Keywords: Smoking; Lung cancer; Smad3; Chemoresistance

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Samanta, D. (2012). Long-term smoking-mediated downregulation of Smad3 induces tumorigenicity and carboplatin resistance in non-small cell lung cancer. (Doctoral Dissertation). Vanderbilt University. Retrieved from http://hdl.handle.net/1803/12131

Chicago Manual of Style (16^th Edition):

Samanta, Debangshu. “Long-term smoking-mediated downregulation of Smad3 induces tumorigenicity and carboplatin resistance in non-small cell lung cancer.” 2012. Doctoral Dissertation, Vanderbilt University. Accessed February 26, 2021. http://hdl.handle.net/1803/12131.

MLA Handbook (7^th Edition):

Samanta, Debangshu. “Long-term smoking-mediated downregulation of Smad3 induces tumorigenicity and carboplatin resistance in non-small cell lung cancer.” 2012. Web. 26 Feb 2021.

Vancouver:

Samanta D. Long-term smoking-mediated downregulation of Smad3 induces tumorigenicity and carboplatin resistance in non-small cell lung cancer. [Internet] [Doctoral dissertation]. Vanderbilt University; 2012. [cited 2021 Feb 26]. Available from: http://hdl.handle.net/1803/12131.

Council of Science Editors:

Samanta D. Long-term smoking-mediated downregulation of Smad3 induces tumorigenicity and carboplatin resistance in non-small cell lung cancer. [Doctoral Dissertation]. Vanderbilt University; 2012. Available from: http://hdl.handle.net/1803/12131

Vanderbilt University

21. Meador, Catherine Belle. Optimizing the sequence of targeted therapy in EGFR-mutant lung adenocarcinoma.

Degree: PhD, Cancer Biology, 2015, Vanderbilt University

URL: http://hdl.handle.net/1803/13334

► EGFR-mutant lung cancers are highly sensitive to EGFR tyrosine kinase inhibitors (TKIs; erlotinib/gefitinib/afatinib), but tumors develop drug resistance within 9-16 months. Resistance to gefitinib/erlotinib commonly… (more)

▼ EGFR-mutant lung cancers are highly sensitive to EGFR tyrosine kinase inhibitors (TKIs; erlotinib/gefitinib/afatinib), but tumors develop drug resistance within 9-16 months. Resistance to gefitinib/erlotinib commonly occurs via a second-site EGFR mutation, T790M. Two strategies to overcome T790M+ resistance are mutant-specific EGFR TKIs, such as AZD9291, and dual inhibition of EGFR with afatinib plus the anti-EGFR antibody, cetuximab (A+C). Unfortunately, ‘second-line’ acquired resistance to A+C and AZD9291, after ‘first-line’ acquired resistance to erlotinib/gefitinib/afatinib, also occurs. To prevent/delay resistance to AZD9291, the combination of AZD9291 plus selumetinib (MEK1/2 inhibitor; AZD6244/ARRY-142886) is also currently being tested in a Phase I clinical trial (NCT02143466). The effects of sequential and combination treatment with various anti-EGFR agents on tumor evolution and drug resistance are largely unknown. In these studies, we modeled drug resistance pre-clinically to: 1. Assess the heterogeneity of mechanisms of first-line resistance to erlotinib and afatinib 2. Determine the optimum order of treatment with A+C vs. AZD9291 in the setting of T790M+ EGFR-mutant lung tumors 3. Elucidate mechanisms of first- and second-line acquired resistance to AZD9291 and 4. Elucidate mechanisms of resistance to AZD9291 plus selumetinib. Next-generation sequencing of genomic DNA from cell line models of resistance to erlotinib/afatinib revealed multiple potentially functional genomic changes within a given pool of resistant cells (including T790M). We also found that AZD9291 is more potent than A+C at inhibiting cell growth in the setting of T790M+ resistance to erlotinib. A+C-resistant cell lines remain sensitive to AZD9291, but AZD9291-resistant cell lines are cross-resistant to A+C. Resistance to AZD9291 is associated with dysregulation of MAPK signaling and can be overcome by addition of the MEK 1/2 inhibitor, selumetinib. Finally, AZD9291 plus selumetinib-resistant cell lines display increased baseline phospho-MEK/ERK and are sensitive to in vitro treatment with an ERK inhibitor, SCH772984 or alternative MEK inhibitor, trametinib. These studies provide a more comprehensive understanding of how EGFR-mutant tumors undergo rewiring of their signaling circuitry in response to single-agent EGFR- and combined EGFR+MEK-inhibition. This work, emphasizing a mechanistic understanding of the effects of therapies on tumor evolution, provides a framework for future clinical trials testing different treatment sequences. Advisors/Committee Members: Christine Lovly (committee member), Jennifer Pietenpol (committee member), William Pao (committee member), Rebecca Cook (Committee Chair).

Subjects/Keywords: targeted therapy; EGFR; lung cancer

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Meador, C. B. (2015). Optimizing the sequence of targeted therapy in EGFR-mutant lung adenocarcinoma. (Doctoral Dissertation). Vanderbilt University. Retrieved from http://hdl.handle.net/1803/13334

Chicago Manual of Style (16^th Edition):

Meador, Catherine Belle. “Optimizing the sequence of targeted therapy in EGFR-mutant lung adenocarcinoma.” 2015. Doctoral Dissertation, Vanderbilt University. Accessed February 26, 2021. http://hdl.handle.net/1803/13334.

MLA Handbook (7^th Edition):

Meador, Catherine Belle. “Optimizing the sequence of targeted therapy in EGFR-mutant lung adenocarcinoma.” 2015. Web. 26 Feb 2021.

Vancouver:

Meador CB. Optimizing the sequence of targeted therapy in EGFR-mutant lung adenocarcinoma. [Internet] [Doctoral dissertation]. Vanderbilt University; 2015. [cited 2021 Feb 26]. Available from: http://hdl.handle.net/1803/13334.

Council of Science Editors:

Meador CB. Optimizing the sequence of targeted therapy in EGFR-mutant lung adenocarcinoma. [Doctoral Dissertation]. Vanderbilt University; 2015. Available from: http://hdl.handle.net/1803/13334

Texas A&M University

22. Partouche Sebban, Julien 1978-. Clinical Implementation of Hypofractionated Radiation therapy for Lung Malignancies.

Degree: PhD, Nuclear Engineering, 2012, Texas A&M University

URL: http://hdl.handle.net/1969.1/157710

► For patients with oligometastases, metastases limited in number and site, the use of radiation therapy treatment with a hypofractionated dose scheme has been proposed as… (more)

▼ For patients with oligometastases, metastases limited in number and site, the use of radiation therapy treatment with a hypofractionated dose scheme has been proposed as a potential ablative approach. There are a limited number of prospective studies looking at hypofractionated radiation therapy (HRT) for lung oligometastasis. Normal lung tissue complication and radiation planning technique are significant limiting factors for the implementation of hypofractionated lung metastasis. The problem statement of this study is how to improve the clinical implementation of HRT for lung metastasis exploring lung toxicity predictors, and developing an efficient radiation planning method. In the first study, we analyzed the dose distribution for 28 patients with lung oligometastasis and treated with HRT to multiple metastases in the lungs. We identified several significant predictors for lung radiation pneumonitis (RP) including the mean lung dose (MLD), V13 and V20. In addition a dose-effect relation between the lung normalized total dose (NTD) and RP may exist up to 48 Gy in three fractions. The dose-response parameters derived in our study appear to agree with other hypofractionated results published in the literature. In the second study, we used an inverse planning algorithm to develop a new radiation planning method by limiting the number of segments per beam angle down to 1 segment. Single segment plans were able to significantly improve tumor coverage and conformality, reduce the risk of lung RP, while simplifying the planning process and delivery. Target conformality and normal lung tissue sparing did not gain much improvement from an increase of plan complexity to five segments over the simplified one segment technique. The automation of our method is a good alternative to more traditional methods and offers significant dosimetric benefits. In the third study, we verified the single segment planning technique via patient specific quality assurance (QA) in a motion phantom. We found good agreement between calculated and measured doses via thermoluminescent detectors (TLD) inside the target. A dose to distance agreement of 3%/3 mm and 2%/2 mm between calculation and film measurements for representative plans in a motion phantom was verified at 98.99% and 97.15%, respectively. Advisors/Committee Members: Ford, John R (advisor), Poston, John W (committee member), Braby, Leslie A (committee member), Walker, Michael (committee member).

Subjects/Keywords: radiation therapy; lung; hypofractionated

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APA (6^th Edition):

Partouche Sebban, J. 1. (2012). Clinical Implementation of Hypofractionated Radiation therapy for Lung Malignancies. (Doctoral Dissertation). Texas A&M University. Retrieved from http://hdl.handle.net/1969.1/157710

Chicago Manual of Style (16^th Edition):

Partouche Sebban, Julien 1978-. “Clinical Implementation of Hypofractionated Radiation therapy for Lung Malignancies.” 2012. Doctoral Dissertation, Texas A&M University. Accessed February 26, 2021. http://hdl.handle.net/1969.1/157710.

MLA Handbook (7^th Edition):

Partouche Sebban, Julien 1978-. “Clinical Implementation of Hypofractionated Radiation therapy for Lung Malignancies.” 2012. Web. 26 Feb 2021.

Vancouver:

Partouche Sebban J1. Clinical Implementation of Hypofractionated Radiation therapy for Lung Malignancies. [Internet] [Doctoral dissertation]. Texas A&M University; 2012. [cited 2021 Feb 26]. Available from: http://hdl.handle.net/1969.1/157710.

Council of Science Editors:

Partouche Sebban J1. Clinical Implementation of Hypofractionated Radiation therapy for Lung Malignancies. [Doctoral Dissertation]. Texas A&M University; 2012. Available from: http://hdl.handle.net/1969.1/157710

Penn State University

23. Crampsie, Melissa Ashley. INVESTIGATION OF THE MECHANISM OF ACTION OF ISOTHIOCYANATE DERIVED ISOSELENOCYANATES AND THE CHEMOPREVENTIVE POTENTIAL OF PHENYLBUTYL ISOSELENOCYANATE .

Degree: 2011, Penn State University

URL: https://submit-etda.libraries.psu.edu/catalog/12391

► Goals of Dissertation Research Lung cancer is currently the leading cause of cancer deaths among men and women and has a survival rate of only… (more)

▼ Goals of Dissertation Research Lung cancer is currently the leading cause of cancer deaths among men and women and has a survival rate of only 16%. Because nearly 90% of lung cancer cases are attributed to smoking tobacco and tobacco related lung cancer has a latency period of 20-30 years from time of exposure to invasive disease, intervention before invasive disease with a chemical agent, termed chemoprevention, is a well suited approach for this particular disease. Research suggests that many natural compounds, often found in the human diet, have chemopreventive properties and are actively being explored and/or can make excellent lead compounds. Our lab, using rational drug design techniques, developed a novel isoselenocyanate compound known as phenylbutyl isoselenocyanate (ISC-4) based on naturally occurring compounds found in cruciferous vegetables. The central hypothesis of this research was that ISC-4, based on its design, would function as a potent and effective anti-cancer agent and could be used as a chemopreventive agent. Specific Aims Specific Aim 1: To determine the effects of replacing the sulfur atom of a panel of phenyl alkyl isothiocyanates with selenium to form a new panel of phenyl alkyl isoselenocyanates (Chapter 2). A structure activity study was performed on the panel of parent isothiocyanate compounds and the resulting panel of isoselenocyanate compounds to determine if mechanistic characteristics were retained and to ascertain a reason for increased activity. Specific Aim 2: Testing the hypothesis that ISC-4 has potential as a chemopreventive agent (Chapter 3). This drug was found to potently target and inhibit carcinogen bioactivation by cytochrome P450 enzymes, including the tobacco specific nitrosamine procarcinogen, N-nitrosyl ketone (NNK). When bioactivated, NNK can lead to mutations in DNA and ultimately result in tumorigenesis. A series of experiments were conducted to assess chemopreventive properties including bioavailability, anti-initiation, and DNA adduct studies, all of which were needed as proof of concept before performing an animal bioassay. Specific Aim 3: Testing ISC-4 as a chemopreventive agent in a lung cancer chemoprevention bioassay (Chapter 4). Using an A/J mouse model, ISC-4 at varying doses and along with its sulfur analog PBITC were tested for the ability to inhibit NNK induced lung tumorigenesis over a 24 week period of time. Original Breakthroughs and Findings Isoselenocyanate (ISC) compounds were actually found to have increased activity with cellular thiols compared to their corresponding sulfur analogs leading to the hypothesis that specific protein modifications and redox activity in the cell are responsible for the increased activities seen with the ISC compounds. As Phase I cytochrome P450s were identified early as a significant protein target of ISC-4, the cancer chemopreventive properties of this compound were explored. ISC-4 was found to be orally bioavailable, able to transcriptionally induce Phase II detoxification enzymes, and inhibit DNA adduct… Advisors/Committee Members: Shantu G Amin, Dissertation Advisor/Co-Advisor, Shantu G Amin, Committee Chair/Co-Chair, Arun Kumar Sharma, Committee Chair/Co-Chair, Kelly J Karpa, Committee Member, Bogdan Prokopczyk, Committee Member, Gary H Perdew, Committee Member, Richard Robert Young, Committee Member.

Subjects/Keywords: ISC-4; lung cancer; chemoprevention

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APA (6^th Edition):

Crampsie, M. A. (2011). INVESTIGATION OF THE MECHANISM OF ACTION OF ISOTHIOCYANATE DERIVED ISOSELENOCYANATES AND THE CHEMOPREVENTIVE POTENTIAL OF PHENYLBUTYL ISOSELENOCYANATE . (Thesis). Penn State University. Retrieved from https://submit-etda.libraries.psu.edu/catalog/12391

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Crampsie, Melissa Ashley. “INVESTIGATION OF THE MECHANISM OF ACTION OF ISOTHIOCYANATE DERIVED ISOSELENOCYANATES AND THE CHEMOPREVENTIVE POTENTIAL OF PHENYLBUTYL ISOSELENOCYANATE .” 2011. Thesis, Penn State University. Accessed February 26, 2021. https://submit-etda.libraries.psu.edu/catalog/12391.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Crampsie, Melissa Ashley. “INVESTIGATION OF THE MECHANISM OF ACTION OF ISOTHIOCYANATE DERIVED ISOSELENOCYANATES AND THE CHEMOPREVENTIVE POTENTIAL OF PHENYLBUTYL ISOSELENOCYANATE .” 2011. Web. 26 Feb 2021.

Vancouver:

Crampsie MA. INVESTIGATION OF THE MECHANISM OF ACTION OF ISOTHIOCYANATE DERIVED ISOSELENOCYANATES AND THE CHEMOPREVENTIVE POTENTIAL OF PHENYLBUTYL ISOSELENOCYANATE . [Internet] [Thesis]. Penn State University; 2011. [cited 2021 Feb 26]. Available from: https://submit-etda.libraries.psu.edu/catalog/12391.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Crampsie MA. INVESTIGATION OF THE MECHANISM OF ACTION OF ISOTHIOCYANATE DERIVED ISOSELENOCYANATES AND THE CHEMOPREVENTIVE POTENTIAL OF PHENYLBUTYL ISOSELENOCYANATE . [Thesis]. Penn State University; 2011. Available from: https://submit-etda.libraries.psu.edu/catalog/12391

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Texas Southwestern Medical Center

24. Patrick, David M. Regulation of Cellular Growth and Differentiation by MicroRNAs -21 and -451.

Degree: 2013, University of Texas Southwestern Medical Center

URL: http://hdl.handle.net/2152.5/1705

► MicroRNAs are small RNAs approximately 20-24 nucleotides in length that are conserved throughout evolution. MicroRNA genes are transcribed by RNA polymerase II and are processed… (more)

▼ MicroRNAs are small RNAs approximately 20-24 nucleotides in length that are conserved throughout evolution. MicroRNA genes are transcribed by RNA polymerase II and are processed both in the nucleus and the cytoplasm from longer precursor RNAs. Functionally, microRNAs interact with Argonaute proteins and guide the formation of a complex with messenger RNAs by Watson-Crick base-pair formation between the microRNA and mRNA. This association stimulates the formation of the microRNA-RNA-induced silencing complex which, upon association with essential adaptor molecules such as GW182, recruits transcriptional repressors and mRNA destabilizers. Essential developmental processes such as embryonic stem cell differentiation and cardiovascular development have been shown to be dependent upon microRNAs. MicroRNAs also participate in a variety of disease processes including tumorigenesis and cardiovascular disease. MicroRNA-451 (miR-451) is regulated during erythrocyte terminal differentiation. The expression of miR-451 is restricted to late erythrocyte precursors and terminally differentiated erythrocytes. We therefore hypothesized that miR-451 plays a role in terminal erythroid differentiation. Deletion of miR-451 in mice results in a terminal erythroid differentiation defect both embryonically and in adulthood. These animals display a reduction in hematocrit and an inability to sustain a high erythropoietic rate. Transient inhibition of miR-451 results in the same defect. Transcript profiling of miR-451-/- erythroblasts revealed upregulation of 14-3-3ξ, a molecule implicated in the regulation of hematopoiesis. Knockdown of 14-3-3ξ with shRNA in miR-451-/- erythroblasts attenuates the differentiation defect. These data show the essential role of miR-451 repression of 14-3-3ξ during terminal erythrocyte differentiation. Finally, the potent effect of miR-451 inhibition on erythrocyte production suggests that this strategy may be efficacious for the treatment of polycythemia vera, a myeloproliferative neoplasm characterzed by excessive erythrocyte production. Inhibition of miR-451 in a mouse model of PV significantly reduces disease burden. MicroRNA-21 (miR-21) is regulated in a variety of both human and mouse models of disease. MiR-21 has been widely reported as a driver of tumorigenesis and is consistently upregulated in cardiac remodeling. It has been suggested that miR-21 plays a protective role during cardiac hypertrophy, however, an opposing report suggests that miR-21 inhibition is beneficial in a mouse model of cardiac remodeling. We therefore hypothesized that miR-21 played an essential role in cardiac hypertrophy and remodeling. Deletion of miR-21 in mice resulted in no observable phenotype. MiR-21-/- displayed cardiac remodeling, cardiac stress-responsive gene activation, and reduction in cardiac function in response to four cardiac stress models: thoracic aortic constriction, angiotensin II infusion, calcineurin overexpression, and myocardial infarction. Moreover, inhibition of miR-21 with an LNA-modified miR-21… Advisors/Committee Members: Olson, Eric N., MacDonald, Raymond J., Hill, Joseph A., Johnson, Jane E., Huang, Lily.

Subjects/Keywords: Lung Neoplasms; MicroRNAs; Polycythemia Vera

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APA (6^th Edition):

Patrick, D. M. (2013). Regulation of Cellular Growth and Differentiation by MicroRNAs -21 and -451. (Thesis). University of Texas Southwestern Medical Center. Retrieved from http://hdl.handle.net/2152.5/1705

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Patrick, David M. “Regulation of Cellular Growth and Differentiation by MicroRNAs -21 and -451.” 2013. Thesis, University of Texas Southwestern Medical Center. Accessed February 26, 2021. http://hdl.handle.net/2152.5/1705.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Patrick, David M. “Regulation of Cellular Growth and Differentiation by MicroRNAs -21 and -451.” 2013. Web. 26 Feb 2021.

Vancouver:

Patrick DM. Regulation of Cellular Growth and Differentiation by MicroRNAs -21 and -451. [Internet] [Thesis]. University of Texas Southwestern Medical Center; 2013. [cited 2021 Feb 26]. Available from: http://hdl.handle.net/2152.5/1705.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Patrick DM. Regulation of Cellular Growth and Differentiation by MicroRNAs -21 and -451. [Thesis]. University of Texas Southwestern Medical Center; 2013. Available from: http://hdl.handle.net/2152.5/1705

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Texas Southwestern Medical Center

25. Thomas, Anna Johnson. Engagement in Care among Patients with Lung Cancer.

Degree: 2016, University of Texas Southwestern Medical Center

URL: http://hdl.handle.net/2152.5/5746

► BACKGROUND: Engagement in care broadly refers to patients' knowledge, skills, ability and willingness to play an active role in their health. Patient activation is a… (more)

Subjects/Keywords: Depression; Lung Neoplasms; Patient Participation

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APA (6^th Edition):

Thomas, A. J. (2016). Engagement in Care among Patients with Lung Cancer. (Thesis). University of Texas Southwestern Medical Center. Retrieved from http://hdl.handle.net/2152.5/5746

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Thomas, Anna Johnson. “Engagement in Care among Patients with Lung Cancer.” 2016. Thesis, University of Texas Southwestern Medical Center. Accessed February 26, 2021. http://hdl.handle.net/2152.5/5746.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Thomas, Anna Johnson. “Engagement in Care among Patients with Lung Cancer.” 2016. Web. 26 Feb 2021.

Vancouver:

Thomas AJ. Engagement in Care among Patients with Lung Cancer. [Internet] [Thesis]. University of Texas Southwestern Medical Center; 2016. [cited 2021 Feb 26]. Available from: http://hdl.handle.net/2152.5/5746.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Thomas AJ. Engagement in Care among Patients with Lung Cancer. [Thesis]. University of Texas Southwestern Medical Center; 2016. Available from: http://hdl.handle.net/2152.5/5746

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

North Carolina State University

26. Cesta, Mark Francis. Contribution of Bacterial Lipopolysaccharide to Carbon Nanotube- and Vanadium Pentoxide-Induced Pulmonary Fibrosis in Rats.

Degree: PhD, Comparative Biomedical Sciences, 2010, North Carolina State University

URL: http://www.lib.ncsu.edu/resolver/1840.16/6162

► Pulmonary fibrosis is typically accompanied by inflammation, which is thought to play a role in its pathogenesis, and occurs with occupational exposure to particulates and… (more)

▼ Pulmonary fibrosis is typically accompanied by inflammation, which is thought to play a role in its pathogenesis, and occurs with occupational exposure to particulates and metals, such as asbestos and vanadium pentoxide (V2O5). Lipopolysaccharide (LPS), a model of acute lung injury and inflammation, chronic bronchitis, and pulmonary fibrosis, upregulates platelet-derived growth factor receptor (PDGF-RÎ±) in rat lung fibroblasts (RLF). PDGF, a potent mitogen and chemoattractant for mesenchymal cells, is an important mediator in fibrotic lung diseases. This dissertation examines the effects of pre-existing inflammation, induced by LPS, on carbon nanotube (CNT)- and V2O5-induced pulmonary fibrosis in rats and the involvement of PDGF signaling. Rats were pretreated with 2.5 mg/kg LPS by intranasal aspiration, followed 24 hr later by 4 mg /kg CNT, carbon black (CB), or V2O5 administered by intratracheal instillation. Total and differential cell counts, lactate dehydrogenase (LDH), total protein, and PDGF and transforming growth factor-Î² (TGF-Î²) protein levels (by ELISA) were examined in bronchoalveolar lavage (BAL) fluid of control and CB- and MWCNT â€“exposed rats. Lungs from all animals were collected for histopathological analysis, immunohistochemistry, and qPCR of the Pdgf-a, Pdgf-c, Pdgf-rÎ±, and Tgf-Î² genes. Pdgf-a, Pdgf-c, Pdgf-rÎ±, Tgf-Î², and Col1a2 gene expression was also measured in vitro in RLF and NR8383 rat alveolar macrophages in response to CNT or CB with and without LPS. In vivo, CNT and CB caused fibroproliferative, granulomatous lesions, which were located primarily in the alveolar ducts and alveoli. Pretreatment with LPS significantly increased collagen deposition associated with these lesions. In the BAL fluid, LPS pretreatment lead to increases in LDH, total protein, and PDGF-AA protein in rats exposed to MWCNT, and an increase in inflammatory cells in CB-exposed rats compared to controls. In vitro, LPS stimulated Pdgf-rÎ± gene expression in RLF, and LPS and nanoparticles synergistically increased Pdgf-a expression in NR8383 cells. Combined LPS/V2O5 exposure augmented V2O5-induced pulmonary inflammation, airway epithelial necrosis, and fibrosis and amplified in vivo collagen gene expression. The airway lesions were of particular interest because LPS pretreatment increased the incidence of bronchiolitis obliterans-like lesions, including subepithelial fibrosis and intraluminal fibrotic polyps. These data confirm that LPS pretreatment augments the fibrotic effects of CNT and V2O5 in rats, which likely involves enhanced PDGF signaling. This dissertation provides evidence that pre-existing pulmonary inflammation, as occurs with chronic obstructive pulmonary diseases or cigarette smoking, can enhance pulmonary fibrotic responses to environmental agents. Furthermore, exposure to environmental LPS may play a role in the pathogenesis of some fibrotic lung diseases. Advisors/Committee Members: Dr. James C. Bonner, Committee Co-Chair (advisor), Dr. David E. Malarkey, Committee Member (advisor), Dr. Kenneth B. Adler, Committee Member (advisor), Dr. Philip L. Sannes, Committee Chair (advisor).

Subjects/Keywords: lung; lipoplysaccharide; nanotube; vanadium; fibrosis

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APA (6^th Edition):

Cesta, M. F. (2010). Contribution of Bacterial Lipopolysaccharide to Carbon Nanotube- and Vanadium Pentoxide-Induced Pulmonary Fibrosis in Rats. (Doctoral Dissertation). North Carolina State University. Retrieved from http://www.lib.ncsu.edu/resolver/1840.16/6162

Chicago Manual of Style (16^th Edition):

Cesta, Mark Francis. “Contribution of Bacterial Lipopolysaccharide to Carbon Nanotube- and Vanadium Pentoxide-Induced Pulmonary Fibrosis in Rats.” 2010. Doctoral Dissertation, North Carolina State University. Accessed February 26, 2021. http://www.lib.ncsu.edu/resolver/1840.16/6162.

MLA Handbook (7^th Edition):

Cesta, Mark Francis. “Contribution of Bacterial Lipopolysaccharide to Carbon Nanotube- and Vanadium Pentoxide-Induced Pulmonary Fibrosis in Rats.” 2010. Web. 26 Feb 2021.

Vancouver:

Cesta MF. Contribution of Bacterial Lipopolysaccharide to Carbon Nanotube- and Vanadium Pentoxide-Induced Pulmonary Fibrosis in Rats. [Internet] [Doctoral dissertation]. North Carolina State University; 2010. [cited 2021 Feb 26]. Available from: http://www.lib.ncsu.edu/resolver/1840.16/6162.

Council of Science Editors:

Cesta MF. Contribution of Bacterial Lipopolysaccharide to Carbon Nanotube- and Vanadium Pentoxide-Induced Pulmonary Fibrosis in Rats. [Doctoral Dissertation]. North Carolina State University; 2010. Available from: http://www.lib.ncsu.edu/resolver/1840.16/6162

University of Toronto

27. Babaev, Arkady. The Effect of Red Blood Cell-derived Lipids on Epithelial and Endothelial Injury.

Degree: 2015, University of Toronto

URL: http://hdl.handle.net/1807/69581

►

Transfusion-related acute lung injury (TRALI) is a major complication resulting from transfusion and the leading cause of transfusion-related fatalities. In recent years, focus has shifted… (more)

Subjects/Keywords: Injury; Lung; RBC; TRALI; 0719

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APA (6^th Edition):

Babaev, A. (2015). The Effect of Red Blood Cell-derived Lipids on Epithelial and Endothelial Injury. (Masters Thesis). University of Toronto. Retrieved from http://hdl.handle.net/1807/69581

Chicago Manual of Style (16^th Edition):

Babaev, Arkady. “The Effect of Red Blood Cell-derived Lipids on Epithelial and Endothelial Injury.” 2015. Masters Thesis, University of Toronto. Accessed February 26, 2021. http://hdl.handle.net/1807/69581.

MLA Handbook (7^th Edition):

Babaev, Arkady. “The Effect of Red Blood Cell-derived Lipids on Epithelial and Endothelial Injury.” 2015. Web. 26 Feb 2021.

Vancouver:

Babaev A. The Effect of Red Blood Cell-derived Lipids on Epithelial and Endothelial Injury. [Internet] [Masters thesis]. University of Toronto; 2015. [cited 2021 Feb 26]. Available from: http://hdl.handle.net/1807/69581.

Council of Science Editors:

Babaev A. The Effect of Red Blood Cell-derived Lipids on Epithelial and Endothelial Injury. [Masters Thesis]. University of Toronto; 2015. Available from: http://hdl.handle.net/1807/69581

University of Toronto

28. Frost, Geoffrey. The Effect of Rotation on the Decellularization of Porcine Lungs.

Degree: 2012, University of Toronto

URL: http://hdl.handle.net/1807/33422

►

This thesis examines the challenges of decellularizing porcine lungs. The thesis identifies hydrostatic pressure and the role it plays in perfusate distribution within the lung… (more)

Subjects/Keywords: Decellularization; Lung; Porcine; Rotation; 0541

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Frost, G. (2012). The Effect of Rotation on the Decellularization of Porcine Lungs. (Masters Thesis). University of Toronto. Retrieved from http://hdl.handle.net/1807/33422

Chicago Manual of Style (16^th Edition):

Frost, Geoffrey. “The Effect of Rotation on the Decellularization of Porcine Lungs.” 2012. Masters Thesis, University of Toronto. Accessed February 26, 2021. http://hdl.handle.net/1807/33422.

MLA Handbook (7^th Edition):

Frost, Geoffrey. “The Effect of Rotation on the Decellularization of Porcine Lungs.” 2012. Web. 26 Feb 2021.

Vancouver:

Frost G. The Effect of Rotation on the Decellularization of Porcine Lungs. [Internet] [Masters thesis]. University of Toronto; 2012. [cited 2021 Feb 26]. Available from: http://hdl.handle.net/1807/33422.

Council of Science Editors:

Frost G. The Effect of Rotation on the Decellularization of Porcine Lungs. [Masters Thesis]. University of Toronto; 2012. Available from: http://hdl.handle.net/1807/33422

University of Guelph

29. ter Woort, Federica. Histologic Evaluation of the Lung in Actively Racing Horses.

Degree: Doctor of Veterinary Science, Department of Clinical Studies, 2012, University of Guelph

URL: https://atrium.lib.uoguelph.ca/xmlui/handle/10214/3910

► Inflammatory Airway Disease has been reported in young racehorses worldwide. The aim of this study was to determine the prevalence of airway inflammation in an… (more)

Subjects/Keywords: Racing; Horse; Histology; lung; inflammation

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

ter Woort, F. (2012). Histologic Evaluation of the Lung in Actively Racing Horses. (Doctoral Dissertation). University of Guelph. Retrieved from https://atrium.lib.uoguelph.ca/xmlui/handle/10214/3910

Chicago Manual of Style (16^th Edition):

ter Woort, Federica. “Histologic Evaluation of the Lung in Actively Racing Horses.” 2012. Doctoral Dissertation, University of Guelph. Accessed February 26, 2021. https://atrium.lib.uoguelph.ca/xmlui/handle/10214/3910.

MLA Handbook (7^th Edition):

ter Woort, Federica. “Histologic Evaluation of the Lung in Actively Racing Horses.” 2012. Web. 26 Feb 2021.

Vancouver:

ter Woort F. Histologic Evaluation of the Lung in Actively Racing Horses. [Internet] [Doctoral dissertation]. University of Guelph; 2012. [cited 2021 Feb 26]. Available from: https://atrium.lib.uoguelph.ca/xmlui/handle/10214/3910.

Council of Science Editors:

ter Woort F. Histologic Evaluation of the Lung in Actively Racing Horses. [Doctoral Dissertation]. University of Guelph; 2012. Available from: https://atrium.lib.uoguelph.ca/xmlui/handle/10214/3910

University of Illinois – Chicago

30. Chen, Jr-Shin. Improved Lung Nodules Detection with Active Contour Method and Machine Learning Based Classification.

Degree: 2015, University of Illinois – Chicago

URL: http://hdl.handle.net/10027/19404

► Computed tomography (CT) scan is one of the widely used medical diagnostic procedures to generate section images of the lung. CT scan employs computer-processed X-rays… (more)

Subjects/Keywords: Lung nodule; CT; Active contour

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Chen, J. (2015). Improved Lung Nodules Detection with Active Contour Method and Machine Learning Based Classification. (Thesis). University of Illinois – Chicago. Retrieved from http://hdl.handle.net/10027/19404

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Chen, Jr-Shin. “Improved Lung Nodules Detection with Active Contour Method and Machine Learning Based Classification.” 2015. Thesis, University of Illinois – Chicago. Accessed February 26, 2021. http://hdl.handle.net/10027/19404.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Chen, Jr-Shin. “Improved Lung Nodules Detection with Active Contour Method and Machine Learning Based Classification.” 2015. Web. 26 Feb 2021.

Vancouver:

Chen J. Improved Lung Nodules Detection with Active Contour Method and Machine Learning Based Classification. [Internet] [Thesis]. University of Illinois – Chicago; 2015. [cited 2021 Feb 26]. Available from: http://hdl.handle.net/10027/19404.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Chen J. Improved Lung Nodules Detection with Active Contour Method and Machine Learning Based Classification. [Thesis]. University of Illinois – Chicago; 2015. Available from: http://hdl.handle.net/10027/19404

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Open Access Theses and Dissertations