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University of Cape Town
1.
Oosthuizen, Sarel Francois.
A Radiological study of the Right Lung.
Degree: Doctoral, Medicine, 1943, University of Cape Town
URL: http://hdl.handle.net/11427/31911
The purpose of this thesis is to illustrate the author's observations on radiological investigations of the right lung both in the living body and at post-mortem, and to describe certain aspects of anatomical, clinical, pathological and radiological interest.
Subjects/Keywords: Lung
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APA (6th Edition):
Oosthuizen, S. F. (1943). A Radiological study of the Right Lung. (Doctoral Dissertation). University of Cape Town. Retrieved from http://hdl.handle.net/11427/31911
Chicago Manual of Style (16th Edition):
Oosthuizen, Sarel Francois. “A Radiological study of the Right Lung.” 1943. Doctoral Dissertation, University of Cape Town. Accessed February 26, 2021.
http://hdl.handle.net/11427/31911.
MLA Handbook (7th Edition):
Oosthuizen, Sarel Francois. “A Radiological study of the Right Lung.” 1943. Web. 26 Feb 2021.
Vancouver:
Oosthuizen SF. A Radiological study of the Right Lung. [Internet] [Doctoral dissertation]. University of Cape Town; 1943. [cited 2021 Feb 26].
Available from: http://hdl.handle.net/11427/31911.
Council of Science Editors:
Oosthuizen SF. A Radiological study of the Right Lung. [Doctoral Dissertation]. University of Cape Town; 1943. Available from: http://hdl.handle.net/11427/31911

Universidad de Cantabria
2.
Duerto Álvarez, Jorge.
Efecto a largo plazo en los injertos renales de un protocolo de manejo intensivo del donante multiorgánico.
Degree: 2016, Universidad de Cantabria
URL: http://hdl.handle.net/10902/9627
► La escasez de órganos disponibles para trasplante es la principal limitación en el desarrollo de esta terapia. Esto es especialmente acusado en el trasplante pulmonar,…
(more)
▼ La escasez de órganos disponibles para trasplante es la principal limitación en el desarrollo de esta terapia. Esto es especialmente acusado en el trasplante pulmonar, donde solo el 20% de los donantes proporcionan injertos válidos para trasplante. La mayoría de las propuestas de manejo del donante pulmonar basadas en una ventilación mecánica protectora y maniobras de reclutamiento, el manejo hemodinámico invasivo con restricción hídrica y hormonoterapia se centran únicamente en el resultado del injerto pulmonar, sin estudiar la influencia en el resto de órganos trasplantados. Este trabajo estudio evalúa el impacto de un protocolo de manejo intensivo del donante pulmonar sobre el injerto renal a largo plazo.
Las conclusiones son:
La aplicación de este protocolo de manejo del donante multiorgánico aumenta la tasa de injertos pulmonares válidos para trasplante.
Los receptores de estos injertos pulmonares presentan una supervivencia a 5 años similar respecto a los receptores cuyos donantes fueron manejados de forma tradicional.
A pesar de que se observó una tendencia a presentar mayor función retrasada del injerto renal, la supervivencia de los injertos renales a 5 años fue similar, confirmando que no se afecta a la funcionalidad renal.
Advisors/Committee Members: Miñambres García, Eduardo (advisor), Universidad de Cantabria (other).
Subjects/Keywords: Lung donor
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APA (6th Edition):
Duerto Álvarez, J. (2016). Efecto a largo plazo en los injertos renales de un protocolo de manejo intensivo del donante multiorgánico. (Doctoral Dissertation). Universidad de Cantabria. Retrieved from http://hdl.handle.net/10902/9627
Chicago Manual of Style (16th Edition):
Duerto Álvarez, Jorge. “Efecto a largo plazo en los injertos renales de un protocolo de manejo intensivo del donante multiorgánico.” 2016. Doctoral Dissertation, Universidad de Cantabria. Accessed February 26, 2021.
http://hdl.handle.net/10902/9627.
MLA Handbook (7th Edition):
Duerto Álvarez, Jorge. “Efecto a largo plazo en los injertos renales de un protocolo de manejo intensivo del donante multiorgánico.” 2016. Web. 26 Feb 2021.
Vancouver:
Duerto Álvarez J. Efecto a largo plazo en los injertos renales de un protocolo de manejo intensivo del donante multiorgánico. [Internet] [Doctoral dissertation]. Universidad de Cantabria; 2016. [cited 2021 Feb 26].
Available from: http://hdl.handle.net/10902/9627.
Council of Science Editors:
Duerto Álvarez J. Efecto a largo plazo en los injertos renales de un protocolo de manejo intensivo del donante multiorgánico. [Doctoral Dissertation]. Universidad de Cantabria; 2016. Available from: http://hdl.handle.net/10902/9627

Oklahoma State University
3.
Wang, Yang.
Functions of Micrornas in Lung Injury and Development.
Degree: Veterinary Pathobiology, 2011, Oklahoma State University
URL: http://hdl.handle.net/11244/7677
► The purpose of this study is to figure out what are the functions of microRNAs in lung development and injury. First, a microRNA microarray was…
(more)
▼ The purpose of this study is to figure out what are the functions of microRNAs in lung development and injury. First, a microRNA microarray was set up to profile expression pattern of microRNAs in various biological processes in the lung. Lung specific microRNAs were identified using this method. Expression patterns of microRNAs in fetal lung development and alveolar epithelial cell trans-differentiation were also uncovered with this platform. The expression profiles were then verified with Northern blots and microRNA qRT-PCR. Expression of miR-127 in the fetal lung reach peak at the late stage of fetal development. Overexpression of miR-127 interrupted fetal lung morphogenesis. miR-375 is significantly decreased during alveolar epithelial cell trans-differentiation. Overexpression of miR-375 interrupted this process by inhibiting the Wnt/β-catenin signaling pathway. Expression of miR-124 is decreased during fetal lung development. miR-124 inhibits fetal alveolar epithelial cell maturation, as indicated
Subjects/Keywords: lung; microrna
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APA (6th Edition):
Wang, Y. (2011). Functions of Micrornas in Lung Injury and Development. (Thesis). Oklahoma State University. Retrieved from http://hdl.handle.net/11244/7677
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Wang, Yang. “Functions of Micrornas in Lung Injury and Development.” 2011. Thesis, Oklahoma State University. Accessed February 26, 2021.
http://hdl.handle.net/11244/7677.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Wang, Yang. “Functions of Micrornas in Lung Injury and Development.” 2011. Web. 26 Feb 2021.
Vancouver:
Wang Y. Functions of Micrornas in Lung Injury and Development. [Internet] [Thesis]. Oklahoma State University; 2011. [cited 2021 Feb 26].
Available from: http://hdl.handle.net/11244/7677.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Wang Y. Functions of Micrornas in Lung Injury and Development. [Thesis]. Oklahoma State University; 2011. Available from: http://hdl.handle.net/11244/7677
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
4.
Sinzala, Martha.
Prevalence and factors associated with acute occupational lung disease among Cotton Ginnery workers in Katete District.
Degree: 2014, University of Zimbabwe
URL: http://dspace.unza.zm/handle/123456789/3206
► The presence of byssinosis among workers in cotton ginneries has been well documented in studies from several countries.However, no studies had been performed among cotton…
(more)
▼ The presence of byssinosis among workers in cotton ginneries has been well documented in studies from several countries.However, no studies had been performed among cotton workers in the Eastern Province of Zambia. In view of this, a cross sectional study design with 151 sample elements, drawn from Dunavant Ginnery in Katete, was employed. The main purpose of the study was to find out the prevalence of byssinosis among cotton ginnery workers. A survey questionnaire and lung function tests were conducted by a trained technician using a spirobank G spirometer. At the time of the study, the workers were employed in five departments and just about half n= 77 (51.1%) were involved in carding with 48.1% involved in other jobs. The longest a worker had served the company was 180 months or fifteen years and the least was barely one month.Out of the 151 workers, only 50 workers (33.1%) did not experience any symptoms of byssinosis. A greater number suffered from chest tightness and/or shortness of breath on most of first days back at work and on the first and other days of the working week. However, 76 (50.6%) of the workers showed a reduction in one symptom over the weekends and an increase in another within the week. Using the generally accepted World Health Organisation (WHO) (1983) criteria, this study found evidence for byssinosis among cotton workers with the highest prevalence of among those who at the time of the study had been engaged in carding, blending, and cleaning processes. The prevalence of byssinosis among cotton workers was 67%. Lung functional tests showed a peculiar trend of decline from day one today four in this sample under study. Of the four lung function tests, Forced Expiratory Volume per second (FEVs) and Forced Vital Capacity (FVC) showed more consistent reduction changes. However, all lung function tests were not significantly associated with work induced byssinotic symptoms. It can, therefore, be concluded on the basis of the study that byssinosis occurs in cotton workers particularly in those who are exposed to high concentrations of dust for a longer period especially in unmanaged and unprotected working environments. The study recommends the provision of protective clothing, environmental hygiene and periodic medical examination at two yearly intervals to identify those who ultimately will have to leave the industry because of progressive symptoms.
Subjects/Keywords: Lung Disease; Respiratory Distress; Lung Diseases
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Sinzala, M. (2014). Prevalence and factors associated with acute occupational lung disease among Cotton Ginnery workers in Katete District. (Thesis). University of Zimbabwe. Retrieved from http://dspace.unza.zm/handle/123456789/3206
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Sinzala, Martha. “Prevalence and factors associated with acute occupational lung disease among Cotton Ginnery workers in Katete District.” 2014. Thesis, University of Zimbabwe. Accessed February 26, 2021.
http://dspace.unza.zm/handle/123456789/3206.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Sinzala, Martha. “Prevalence and factors associated with acute occupational lung disease among Cotton Ginnery workers in Katete District.” 2014. Web. 26 Feb 2021.
Vancouver:
Sinzala M. Prevalence and factors associated with acute occupational lung disease among Cotton Ginnery workers in Katete District. [Internet] [Thesis]. University of Zimbabwe; 2014. [cited 2021 Feb 26].
Available from: http://dspace.unza.zm/handle/123456789/3206.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Sinzala M. Prevalence and factors associated with acute occupational lung disease among Cotton Ginnery workers in Katete District. [Thesis]. University of Zimbabwe; 2014. Available from: http://dspace.unza.zm/handle/123456789/3206
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
5.
Wang, Zihao.
Conceptualization and design of a future chest drainage canister.
Degree: Umeå Institute of Design, 2016, Umeå University
URL: http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-125683
► Changsha city in Hunan province, China. Place: Changsha Center Hospital, Hunan province. City Area: 11,819 square kilometers City population: 714.66 million I watched the…
(more)
▼ Changsha city in Hunan province, China. Place: Changsha Center Hospital, Hunan province. City Area: 11,819 square kilometers City population: 714.66 million I watched the whole process of chest drainage surgery, introduced by Yang Jicheng, who is a thoracic surgeon attending doctor at this capital. During the field research in China, I also had research opportunity of chest drainage management, mostly performed by nurses, where I found out lots of design opportunities about the Chong canister, which was the most popular chest drainage canister used all over the China Then I went back to Umea, Sweden, met Fredrik Homner who is a thoracic surgery doctor working in Norrlands University Hospital for almost 30 years. I told him what I saw in China and we exchanged lots of opinion about chest drainage. I realized that Chinese chest drainage patients were suffering unnecessary pain from outmoded equipment, which in Sweden they had already updated since 20 years ago. Whit help of Fredrik Holmner, I had opportunity to watch the whole process of pulmonary resection and endoscope technical, the focus of this process was the insertion of chest drainage tube at the end of this 5 hours surgery. After I had seen so many materials related to chest drainage, I found out my design focus, which was the Maquet Oasis Drain, that had been recognized as the most advanced chest drainage equipment in the world and had been widely used in Europe and United States.
Subjects/Keywords: Damaged lung; chest drainage system; collapsed lung
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APA ·
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Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Wang, Z. (2016). Conceptualization and design of a future chest drainage canister. (Thesis). Umeå University. Retrieved from http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-125683
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Wang, Zihao. “Conceptualization and design of a future chest drainage canister.” 2016. Thesis, Umeå University. Accessed February 26, 2021.
http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-125683.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Wang, Zihao. “Conceptualization and design of a future chest drainage canister.” 2016. Web. 26 Feb 2021.
Vancouver:
Wang Z. Conceptualization and design of a future chest drainage canister. [Internet] [Thesis]. Umeå University; 2016. [cited 2021 Feb 26].
Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-125683.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Wang Z. Conceptualization and design of a future chest drainage canister. [Thesis]. Umeå University; 2016. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-125683
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Southern California
6.
Selamat, Suhaida Adura.
DNA methylation changes in the development of lung
adenocarcinoma.
Degree: PhD, Genetic, Molecular and Cellular Biology, 2012, University of Southern California
URL: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/2645/rec/2069
► Lung cancer accounted for 13% of total cancer cases and 18% of cancer deaths globally in 2008. The combination of increasing smoking prevalence in many…
(more)
▼ Lung cancer accounted for 13% of total cancer cases
and 18% of cancer deaths globally in 2008. The combination of
increasing smoking prevalence in many developing countries and a
long latency period predicts that
lung cancer will remain a major
world health problem for decades to come. This work focuses on DNA
methylation in
lung adenocarcinoma, a subtype of
lung cancer that
is the most prevalent in the United States, as well as the most
common amongst women and non-smokers. We built on previously
identified DNA methylation early detection markers by delineating
the timing of these changes in preneoplastic lesions. We then used
genome-scale DNA methylation profiling to identify novel potential
blood-based non-small cell
lung cancer biomarkers, and integrated
DNA methylation information with gene expression data to identify
DNA methylation changes that may lead to functional consequences in
the development of cancer. Additionally, we identified a DNA
methylation based subgroup of
lung adenocarcinoma that is
associated with KRAS mutations and smoking status, as well as
explored the use of paraffin-embedded tissues to facilitate larger
genome-scale DNA methylation studies. Our findings provide insights
into the roles that DNA methylation may play in the development of
lung adenocarcinoma, as well as potential DNA methylation markers
for the early detection or risk assessment of the
disease.
Advisors/Committee Members: Laird-Offringa, Ite A. (Committee Chair), Siegmund, Kimberly (Committee Member), Borok, Zea (Committee Member).
Subjects/Keywords: DNA methylation; lung adenocarcinoma; lung cancer; epigenetics
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APA (6th Edition):
Selamat, S. A. (2012). DNA methylation changes in the development of lung
adenocarcinoma. (Doctoral Dissertation). University of Southern California. Retrieved from http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/2645/rec/2069
Chicago Manual of Style (16th Edition):
Selamat, Suhaida Adura. “DNA methylation changes in the development of lung
adenocarcinoma.” 2012. Doctoral Dissertation, University of Southern California. Accessed February 26, 2021.
http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/2645/rec/2069.
MLA Handbook (7th Edition):
Selamat, Suhaida Adura. “DNA methylation changes in the development of lung
adenocarcinoma.” 2012. Web. 26 Feb 2021.
Vancouver:
Selamat SA. DNA methylation changes in the development of lung
adenocarcinoma. [Internet] [Doctoral dissertation]. University of Southern California; 2012. [cited 2021 Feb 26].
Available from: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/2645/rec/2069.
Council of Science Editors:
Selamat SA. DNA methylation changes in the development of lung
adenocarcinoma. [Doctoral Dissertation]. University of Southern California; 2012. Available from: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/2645/rec/2069

Temple University
7.
Stabler, Collin Turner.
Optimizing Endothelial Repopulation of Decellularized Lung.
Degree: PhD, 2016, Temple University
URL: http://digital.library.temple.edu/u?/p245801coll10,388434
► Bioengineering
Decellularized lung tissue has been recognized as a potential platform to engineer whole lung organs suitable for transplantation or for modeling a variety of…
(more)
▼ Bioengineering
Decellularized lung tissue has been recognized as a potential platform to engineer whole lung organs suitable for transplantation or for modeling a variety of lung diseases. However many technical hurdles remain before this potential may be fully realized. Inability to efficiently re-endothelialize the pulmonary vasculature with a functional endothelium appears to be the primary cause of failure of recellularized lung scaffolds in early transplant studies. This dissertation research aims to enhance the re-endothelialization of decellularized rodent lung scaffolds with rat lung microvascular endothelial cells. This was achieved by adjusting the posture of the lung to a supine position during cell seeding through the pulmonary artery. The supine position allowed for significantly more homogeneous seeding and better cell retention in the apex regions of all lobes than the traditional upright position, especially in the right upper and left lobes. Additionally, the supine position allowed for greater cell retention within large diameter vessels (proximal – 100 µm to 5,000 µm) than the upright position, with little to no difference in the small diameter distal vessels. Endothelial cell adhesion in the proximal regions of the pulmonary vasculature in the decellularized lung was dependent on the binding of endothelial cell integrins, specifically α1β1, α2β1 and α5β1 integrins to, respectively, collagen type-I, type-IV and fibronectin in the residual ECM. Following in vitro maturation of the seeded constructs under perfusion culture, the seeded endothelial cells spread along the vascular wall, leading to a partial re-establishment of endothelial barrier function as inferred from a custom-designed leakage assay. The results of this dissertation research suggest that attention to cellular distribution within the whole organ is of paramount importance for restoring proper vascular function.
Temple University – Theses
Advisors/Committee Members: Lelkes, Peter I.;, Pleshko, Nancy, Marcinkiewicz, Cezary, Wolfson, Marla R., Schulman, Edward S.;.
Subjects/Keywords: Biomedical engineering;
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APA ·
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MLA ·
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APA (6th Edition):
Stabler, C. T. (2016). Optimizing Endothelial Repopulation of Decellularized Lung. (Doctoral Dissertation). Temple University. Retrieved from http://digital.library.temple.edu/u?/p245801coll10,388434
Chicago Manual of Style (16th Edition):
Stabler, Collin Turner. “Optimizing Endothelial Repopulation of Decellularized Lung.” 2016. Doctoral Dissertation, Temple University. Accessed February 26, 2021.
http://digital.library.temple.edu/u?/p245801coll10,388434.
MLA Handbook (7th Edition):
Stabler, Collin Turner. “Optimizing Endothelial Repopulation of Decellularized Lung.” 2016. Web. 26 Feb 2021.
Vancouver:
Stabler CT. Optimizing Endothelial Repopulation of Decellularized Lung. [Internet] [Doctoral dissertation]. Temple University; 2016. [cited 2021 Feb 26].
Available from: http://digital.library.temple.edu/u?/p245801coll10,388434.
Council of Science Editors:
Stabler CT. Optimizing Endothelial Repopulation of Decellularized Lung. [Doctoral Dissertation]. Temple University; 2016. Available from: http://digital.library.temple.edu/u?/p245801coll10,388434

Harvard University
8.
Li, Richard.
Venous Thromboembolism Risk in Patients With Locally Advanced Non-Small Cell Lung Cancer.
Degree: Doctor of Medicine, 2016, Harvard University
URL: http://nrs.harvard.edu/urn-3:HUL.InstRepos:40620276
► Background: Patients with non-small cell lung cancer (NSCLC) are known to be at high risk for venous thromboembolism (VTE), but previous studies have not specifically…
(more)
▼ Background: Patients with non-small cell lung cancer (NSCLC) are known to be at high risk for venous thromboembolism (VTE), but previous studies have not specifically analyzed locally advanced disease. We performed a retrospective VTE risks analysis in a cohort of locally advanced NSCLC treated with definitive radiation.
Methods: The cohort consisted of 629 patients with stage II-III NSCLC treated at a single institution from January 2003 to December 2012. All patients received definitive therapy with curative intent. Fine and Gray’s competing-risks regression model, accounting for death and distant metastasis as competing risks, was used to identify significant predictors of VTE risk, and cumulative incidence estimates were generated using the competing-risks model.
Results: At a median follow-up of 31 months, 127 patients developed a VTE, with 80% of events occurring in the first year after treatment initiation. 1-year and 3-year overall cumulative incidence estimates were 13.5% and 15.4%, respectively. On univariate analysis, stage IIIB and N3 nodal disease were associated with increased VTE risk. In the final multivariate model, N3 nodal disease was associated with increased VTE risk (Hazard ratio 1.64; 95% CI 1.06-2.54; p=0.027).
Conclusions: Patients with locally advanced NSCLC are at high risk for VTE, especially in the first year after treatment initiation, with a 1-year cumulative incidence of 13.5%. N3 nodal staging was associated with significantly higher VTE risk compared to N0-N2 staging.
Scholarly Project
Subjects/Keywords: lung cancer; thromboembolism
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Li, R. (2016). Venous Thromboembolism Risk in Patients With Locally Advanced Non-Small Cell Lung Cancer. (Doctoral Dissertation). Harvard University. Retrieved from http://nrs.harvard.edu/urn-3:HUL.InstRepos:40620276
Chicago Manual of Style (16th Edition):
Li, Richard. “Venous Thromboembolism Risk in Patients With Locally Advanced Non-Small Cell Lung Cancer.” 2016. Doctoral Dissertation, Harvard University. Accessed February 26, 2021.
http://nrs.harvard.edu/urn-3:HUL.InstRepos:40620276.
MLA Handbook (7th Edition):
Li, Richard. “Venous Thromboembolism Risk in Patients With Locally Advanced Non-Small Cell Lung Cancer.” 2016. Web. 26 Feb 2021.
Vancouver:
Li R. Venous Thromboembolism Risk in Patients With Locally Advanced Non-Small Cell Lung Cancer. [Internet] [Doctoral dissertation]. Harvard University; 2016. [cited 2021 Feb 26].
Available from: http://nrs.harvard.edu/urn-3:HUL.InstRepos:40620276.
Council of Science Editors:
Li R. Venous Thromboembolism Risk in Patients With Locally Advanced Non-Small Cell Lung Cancer. [Doctoral Dissertation]. Harvard University; 2016. Available from: http://nrs.harvard.edu/urn-3:HUL.InstRepos:40620276

University of Dundee
9.
Robertson, Holly.
Mechanisms of repression of the transcription factor NRF2 by KEAP1- and B-TrCP-dependent ubiquitin ligases and how the dysregulation of NRF2 contributes to lung cancer progression.
Degree: PhD, 2019, University of Dundee
URL: https://discovery.dundee.ac.uk/en/studentTheses/4a7f87db-89f1-4bc4-b273-1bd7eb72ab0e
;
https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.775364
► Lung cancer is the leading cause of cancer related mortality worldwide and since the discovery of the important role that NRF2 plays in regulating the…
(more)
▼ Lung cancer is the leading cause of cancer related mortality worldwide and since the discovery of the important role that NRF2 plays in regulating the expression of phase II drug metabolism genes, NRF2 has been a highly studied therapeutic target. NRF2 signalling is often elevated in lung cancer due to mutations in NFE2L2, the gene that encodes NRF2; and KEAP1, the cytoplasmic regulator of NRF2. Since it became established that elevated NRF2 signalling provides a beneficial role to the tumour through enhancing proliferation, enabling survival in highly oxidative conditions and enhancing resistance to chemotherapeutic drugs; many groups have focussed on understanding KEAP1-independent forms of NRF2 regulation. It is now widely accepted that GSK-3 phosphorylation of the Neh6 domain of NRF2 is fundamental for SCFβ-TrCP-mediated degradation of the transcription factor. Previous work by other groups has indicated a potential role for a priming kinase to pre-phosphorylate the Neh6 domain and subsequently enhance GSK-3 mediated phosphorylation and resulting 26S proteasomal degradation. In the first results chapter of this thesis it was demonstrated using the DYRK family of isoenzymes that the presence of a priming kinase enhances GSK-3 phosphorylation and stimulates NRF2 degradation. Also, it has been shown that DYRK family members carry out priming of NRF2 through phosphorylating Ser-347, which enhances subsequent phosphorylation of Ser-342 and Ser-338 by GSK-3; regulating both NRF2 activity and stability. Additionally, it was shown that altering the phosphorylation status of Ser-347 impacts cell proliferation and chemo-sensitivity to platinum-based compounds. The ability of other kinases to phosphorylate the Neh6 domain was also revealed. In the second results chapter of this thesis a bioinformatics style approach was utilized to analyse the impact of mutations in KEAP1, NFE2L2 and CUL3; in terms of their effect on NRF2 activity using the expression of NRF2-target genes as a read out. The following points were highlighted from this analysis; (1) KEAP1 mutations are more prevalent than NFE2L2 and CUL3 mutations in both lung cancer cell lines and tumours; (2) KEAP1 and NFE2L2 mutations vary in there associated zygosity's, with KEAP1 mutations being predominantly homozygous and NFE2L2 mutations being predominantly heterozygous; (3) mutations in KEAP1 coexist with mutations in KRAS whereas, mutations in NFE2L2 co-exist with mutations in TP53 and (4) lung cancer cell lines and tumours harbouring mutations in KEAP1 have greater expression of NRF2-target genes than those harbouring either NFE2L2 or CUL3 mutations. In the third and final results chapter, both a panel of commercial cell lines and an in-house generated CRISPR/Cas9 panel of cell lines have been shown in multiple experiments to validate the bioinformatics findings of the previous chapter. Also, in this chapter it was identified that KEAP1 mutant cells are more reliant on the glutathione biosynthesis pathway for survival and therefore more sensitive to alterations in…
Subjects/Keywords: NRF2; Lung Cancer
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APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
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APA (6th Edition):
Robertson, H. (2019). Mechanisms of repression of the transcription factor NRF2 by KEAP1- and B-TrCP-dependent ubiquitin ligases and how the dysregulation of NRF2 contributes to lung cancer progression. (Doctoral Dissertation). University of Dundee. Retrieved from https://discovery.dundee.ac.uk/en/studentTheses/4a7f87db-89f1-4bc4-b273-1bd7eb72ab0e ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.775364
Chicago Manual of Style (16th Edition):
Robertson, Holly. “Mechanisms of repression of the transcription factor NRF2 by KEAP1- and B-TrCP-dependent ubiquitin ligases and how the dysregulation of NRF2 contributes to lung cancer progression.” 2019. Doctoral Dissertation, University of Dundee. Accessed February 26, 2021.
https://discovery.dundee.ac.uk/en/studentTheses/4a7f87db-89f1-4bc4-b273-1bd7eb72ab0e ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.775364.
MLA Handbook (7th Edition):
Robertson, Holly. “Mechanisms of repression of the transcription factor NRF2 by KEAP1- and B-TrCP-dependent ubiquitin ligases and how the dysregulation of NRF2 contributes to lung cancer progression.” 2019. Web. 26 Feb 2021.
Vancouver:
Robertson H. Mechanisms of repression of the transcription factor NRF2 by KEAP1- and B-TrCP-dependent ubiquitin ligases and how the dysregulation of NRF2 contributes to lung cancer progression. [Internet] [Doctoral dissertation]. University of Dundee; 2019. [cited 2021 Feb 26].
Available from: https://discovery.dundee.ac.uk/en/studentTheses/4a7f87db-89f1-4bc4-b273-1bd7eb72ab0e ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.775364.
Council of Science Editors:
Robertson H. Mechanisms of repression of the transcription factor NRF2 by KEAP1- and B-TrCP-dependent ubiquitin ligases and how the dysregulation of NRF2 contributes to lung cancer progression. [Doctoral Dissertation]. University of Dundee; 2019. Available from: https://discovery.dundee.ac.uk/en/studentTheses/4a7f87db-89f1-4bc4-b273-1bd7eb72ab0e ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.775364

University of New South Wales
10.
Wong, Sze Wing (Alice).
Functions of S100A8 in lung cancer.
Degree: Medical Sciences, 2018, University of New South Wales
URL: http://handle.unsw.edu.au/1959.4/60230
;
https://unsworks.unsw.edu.au/fapi/datastream/unsworks:51254/SOURCE02?view=true
► S100A8 is an anti-inflammatory oxidant scavenger protein that induces IL-10 in airway epithelial cells in normal lungs following inhalation. These mechanisms contribute to its ability…
(more)
▼ S100A8 is an anti-inflammatory oxidant scavenger protein that induces IL-10 in airway epithelial cells in normal lungs following inhalation. These mechanisms contribute to its ability to attenuate endotoxin-induced acute lung injury by suppressing proinflammatory mediator induction. Sustained chronic inflammation promotes activation of myeloid-derived suppressor cells (MDSC) to reduce T cell surveillance by producing toxic reactive oxygen species and nitric oxide, and depleting the essential nutrient, arginine. MDSC accumulation facilitates tumour progression and is associated with reduced survival in lung cancer. S100A8 is upregulated in human lung cancer and the associations of S100 proteins with MDSC suggest a potential immunomodulatory role. We proposed that the anti-inflammatory and antioxidative properties of S100A8 improved outcomes in lung cancer. Remarkably, repeated S100A8 inhalation prolonged survival by up to 40% in mice implanted with orthotopic lung cancer (from 19±1 to 27±1 days). Tumour-bearing mice treated with S100A8 harvested at earlier time points were compared with vehicle-treated controls to identify potential changes in the microenvironment. At mid-point of survival, S100A8 significantly suppressed key cytokines that promote MDSC expansion and activation, with concomitant reduced MDSC numbers in lungs and spleen. Importantly, S100A8 also increased CD4 and NK-T cell numbers in these organs, suppressed nitrite levels and selectively enhanced activities of key antioxidant enzymes in lungs. S100A8 also upregulated thioredoxin reductase activity in lungs 3 days post-inhalation. Results suggest that S100A8 created a favourable microenvironment for effector T cell recruitment and function. Lung cancer is generally associated with poor prognosis and with limited treatment options, and S100A8 may enhance immunoprotection. Its delivery in combination with currently-available treatments may improve clinical outcomes.
Subjects/Keywords: Lung cancer; S100A8
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Wong, S. W. (. (2018). Functions of S100A8 in lung cancer. (Doctoral Dissertation). University of New South Wales. Retrieved from http://handle.unsw.edu.au/1959.4/60230 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:51254/SOURCE02?view=true
Chicago Manual of Style (16th Edition):
Wong, Sze Wing (Alice). “Functions of S100A8 in lung cancer.” 2018. Doctoral Dissertation, University of New South Wales. Accessed February 26, 2021.
http://handle.unsw.edu.au/1959.4/60230 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:51254/SOURCE02?view=true.
MLA Handbook (7th Edition):
Wong, Sze Wing (Alice). “Functions of S100A8 in lung cancer.” 2018. Web. 26 Feb 2021.
Vancouver:
Wong SW(. Functions of S100A8 in lung cancer. [Internet] [Doctoral dissertation]. University of New South Wales; 2018. [cited 2021 Feb 26].
Available from: http://handle.unsw.edu.au/1959.4/60230 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:51254/SOURCE02?view=true.
Council of Science Editors:
Wong SW(. Functions of S100A8 in lung cancer. [Doctoral Dissertation]. University of New South Wales; 2018. Available from: http://handle.unsw.edu.au/1959.4/60230 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:51254/SOURCE02?view=true

Dalhousie University
11.
Leary, Del.
MODELING OF SPATIAL AND TEMPORAL HETEROGENEITY OF THE HUMAN
LUNG.
Degree: PhD, Department of Physics & Atmospheric
Science, 2013, Dalhousie University
URL: http://hdl.handle.net/10222/36311
► This thesis investigates variability in airway caliber and the distribution of ventilation within the human lung as thought to occur in asthma. Currently, the understanding…
(more)
▼ This thesis investigates variability in airway caliber
and the distribution of ventilation within the human
lung as
thought to occur in asthma. Currently, the understanding of how an
integrated network of airways can lead to temporal and spatial
variation as found in the human
lung is unclear. Throughout this
thesis, a multibranch airway tree model was used in a forward
modeling approach. In a variability study, the mean airway
resistance (RL) was observed to be proportional to the standard
deviation in airway resistance (SDRL) as reported in the literature
under several conditions of airway diameter indicating the strong
robustness of this behavior. The model predicted previously
reported RL distributions and the reported proportionality of SDRL
and RL, but only when we included coherency between airways. In a
second study, patient specific ventilation was investigated using
an image functional approach by closing specific airways (creating
defects) identified by hyperpolarized 3He MRI from asthmatic
subjects. Impedance predictions from the imposed heterogeneous
ventilation were then calculated and correlated to 3He MRI
ventilation defect percent (VDP), plethysmography, and spirometry
data. These predictions suggest the forced oscillation technique
(FOT) to be a superior metric toward the evaluation of the VDP. In
a third study, we investigated how asymmetric branching could play
a role in ventilation defect emergence and persistence. At high
muscle activation levels simulating an asthmatic episode, airway
trees with greater asymmetry reached steady state sooner, with
defects that were more persistent in location, had lower RL values
(~50%), and greater EL values (~25%) after bronchoconstriction.
These results suggest the initial formation of ventilation defects
was dependent on airway instability; however, the location and
persistence of ventilation defects may be due to geometric airway
structure. By modeling the contribution of ventilation defects to
lung impedance, we were able to show that defects can play a role
in governing the relationship between RL and its variation, and the
effect of defects through VDP could be better assessed using FOT.
Moreover,
lung structure contributed to the emergence and
persistence of ventilation defects, meaning that defects could be
potentially ameliorated through structural
intervention.
Advisors/Committee Members: Jason Bates (external-examiner), Jordan Kyriakidis (graduate-coordinator), Steven Beyea, Grace Parraga, Andrew Rutenberg (thesis-reader), Geoff Maksym (thesis-supervisor), Not Applicable (ethics-approval), Yes (manuscripts), Yes (copyright-release).
Subjects/Keywords: lung modeling; temporal variability; spatial variability;
human lung; lung mechanics
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Leary, D. (2013). MODELING OF SPATIAL AND TEMPORAL HETEROGENEITY OF THE HUMAN
LUNG. (Doctoral Dissertation). Dalhousie University. Retrieved from http://hdl.handle.net/10222/36311
Chicago Manual of Style (16th Edition):
Leary, Del. “MODELING OF SPATIAL AND TEMPORAL HETEROGENEITY OF THE HUMAN
LUNG.” 2013. Doctoral Dissertation, Dalhousie University. Accessed February 26, 2021.
http://hdl.handle.net/10222/36311.
MLA Handbook (7th Edition):
Leary, Del. “MODELING OF SPATIAL AND TEMPORAL HETEROGENEITY OF THE HUMAN
LUNG.” 2013. Web. 26 Feb 2021.
Vancouver:
Leary D. MODELING OF SPATIAL AND TEMPORAL HETEROGENEITY OF THE HUMAN
LUNG. [Internet] [Doctoral dissertation]. Dalhousie University; 2013. [cited 2021 Feb 26].
Available from: http://hdl.handle.net/10222/36311.
Council of Science Editors:
Leary D. MODELING OF SPATIAL AND TEMPORAL HETEROGENEITY OF THE HUMAN
LUNG. [Doctoral Dissertation]. Dalhousie University; 2013. Available from: http://hdl.handle.net/10222/36311

University of Toronto
12.
Reck dos Santos, Pedro Augusto.
Development of In Vivo Lung Perfusion Strategy for the Treatment of Lung Metastases.
Degree: 2015, University of Toronto
URL: http://hdl.handle.net/1807/69694
► In Vivo Lung Perfusion (IVLP) can potentially enhance the treatment of lung metastases by allowing the delivery of elevated doses of chemotherapy to the lungs…
(more)
▼ In Vivo Lung Perfusion (IVLP) can potentially enhance the treatment of lung metastases by allowing the delivery of elevated doses of chemotherapy to the lungs without systemic exposure. Previously, experimental and clinical studies reported questionable efficacy and frequent lung toxicity, hindering the broad application of this technique. We have developed a modified IVLP strategy that avoids acute lung injury using a protective mode of ventilation/perfusion. Our IVLP strategy enabled an extended perfusion time using chemotherapy doses usually given intravenously to patients. Additionally, we successfully administered higher chemotherapy levels in a safe manner and found higher lung tissue levels of chemotherapeutic drugs compared to previous studies. Importantly, these findings were possible without acute lung injury, demonstrating a likely protective effect of our IVLP strategy. This is a significant step towards a safer and more effective IVLP technique to help patients with pulmonary metastases, minimizing the adverse effects of chemotherapy to the lungs.
M.Sc.
Advisors/Committee Members: Cypel, Marcelo, Medical Science.
Subjects/Keywords: In Vivo Lung Perfusion; Isolated Lung Perfusion; Locoregional Therapy; Lung Metastases; Pulmonary Metastasectomy; Sarcomas; 0576
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Reck dos Santos, P. A. (2015). Development of In Vivo Lung Perfusion Strategy for the Treatment of Lung Metastases. (Masters Thesis). University of Toronto. Retrieved from http://hdl.handle.net/1807/69694
Chicago Manual of Style (16th Edition):
Reck dos Santos, Pedro Augusto. “Development of In Vivo Lung Perfusion Strategy for the Treatment of Lung Metastases.” 2015. Masters Thesis, University of Toronto. Accessed February 26, 2021.
http://hdl.handle.net/1807/69694.
MLA Handbook (7th Edition):
Reck dos Santos, Pedro Augusto. “Development of In Vivo Lung Perfusion Strategy for the Treatment of Lung Metastases.” 2015. Web. 26 Feb 2021.
Vancouver:
Reck dos Santos PA. Development of In Vivo Lung Perfusion Strategy for the Treatment of Lung Metastases. [Internet] [Masters thesis]. University of Toronto; 2015. [cited 2021 Feb 26].
Available from: http://hdl.handle.net/1807/69694.
Council of Science Editors:
Reck dos Santos PA. Development of In Vivo Lung Perfusion Strategy for the Treatment of Lung Metastases. [Masters Thesis]. University of Toronto; 2015. Available from: http://hdl.handle.net/1807/69694

University of Gothenburg / Göteborgs Universitet
13.
Wallinder, Andreas.
Ex Vivo Lung Perfusion - clinical and experimental studies.
Degree: 2014, University of Gothenburg / Göteborgs Universitet
URL: http://hdl.handle.net/2077/35943
► For patients who are suffering from end-stage lung disease, lung transplantation is a life-prolonging therapy. The number of donor lungs is limited and the majority…
(more)
▼ For patients who are suffering from end-stage lung disease, lung transplantation is a life-prolonging therapy. The number of donor lungs is limited and the majority of available donor lungs, in some regions up to 85%, are discarded due to known or presumed organ dysfunction. Lung donations after cardiac death (DCD) and increased utilization of lungs from donations after brain death (DBD) could increase the availability of donor organs. Ex vivo lung perfusion (EVLP) is a method that has been developed for the preservation and evaluation of donor lungs during continuous perfusion and ventilation. EVLP is applicable to lungs harvested from DCD, as well as to the lungs of DBD with suboptimal lung function.
Method: In Papers I and II, an uncontrolled DCD situation was simulated in a pig model. The currently suggested protocol for DCD lung procurement, involving post-mortem administration of heparin followed by chest compressions and intrapleural cooling of the lungs to 12°C, was compared to a simplified procurement method that does not use heparin and employs a less-invasive cooling technique. In Papers III–V, the methods and results for EVLP for the salvage of initially rejected human donor lungs were investigated. Rejected donor lungs with inferior function were retrieved and connected to the EVLP system. Assessments of lung function, with respect to circulatory and respiratory parameters, were performed. EVLP-treated lungs that were deemed to have normal function were transplanted into recipients from the conventional waiting list for transplantation. The short-term and long-term outcomes for the recipients of the EVLP-treated lungs were compared to a consecutive series of patients who received non- EVLP lungs prepared according to the standard protocol.
Results: In Papers I and II, the lung function assessed during EVLP and at post-EVLP analyses in terms of the water content of lung tissues and markers of lung injury, did not differ significantly between the treatment and control groups. In Papers III–V, 25 pairs of rejected donor lungs underwent EVLP. Eighteen double lungs and four single lungs were transplanted after EVLP, and the recipients (EVLP group; N=22) were compared with recipients of conventionally prepared lungs (Control group; N=115). The median time to extubation (p=0.26) and the median stay in the intensive care unit (p=0.06) did not differ significantly for the two groups. Primary graft dysfunction higher than grade 1 was noted for 14% of the recipients in the EVLP group and 11% of the Control group at 72 hours post-transplantation. The cumulative 1-year survival rates were 89% for the EVLP group and 82% for the Control group. The cumulative survival rates for up to three years of follow-up were comparable for these two groups (p=0.67).
Conclusion: Papers I and II provide support for the notion that a no-touch period of 1 hour after death in cases of uncontrolled DCD would not compromise donor lung function. This would allow the next-of-kin to spend time with the deceased and to facilitate the…
Subjects/Keywords: Lung transplantation; Ex vivo lung perfusion; Donation after cardiac death; Donor lung procurement
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Wallinder, A. (2014). Ex Vivo Lung Perfusion - clinical and experimental studies. (Thesis). University of Gothenburg / Göteborgs Universitet. Retrieved from http://hdl.handle.net/2077/35943
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Wallinder, Andreas. “Ex Vivo Lung Perfusion - clinical and experimental studies.” 2014. Thesis, University of Gothenburg / Göteborgs Universitet. Accessed February 26, 2021.
http://hdl.handle.net/2077/35943.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Wallinder, Andreas. “Ex Vivo Lung Perfusion - clinical and experimental studies.” 2014. Web. 26 Feb 2021.
Vancouver:
Wallinder A. Ex Vivo Lung Perfusion - clinical and experimental studies. [Internet] [Thesis]. University of Gothenburg / Göteborgs Universitet; 2014. [cited 2021 Feb 26].
Available from: http://hdl.handle.net/2077/35943.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Wallinder A. Ex Vivo Lung Perfusion - clinical and experimental studies. [Thesis]. University of Gothenburg / Göteborgs Universitet; 2014. Available from: http://hdl.handle.net/2077/35943
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universiteit Utrecht
14.
Breeveld, A.R.
Shape of the exposure response relation for crystalline silica and risk of lung cancer.
Degree: 2011, Universiteit Utrecht
URL: http://dspace.library.uu.nl:8080/handle/1874/209135
► Crystalline silica exposure mostly occurs in occupational settings such as mining, construction, several industries (e.g. foundries) and agriculture. Occupational exposure to silica dust is known…
(more)
▼ Crystalline silica exposure mostly occurs in occupational settings such as mining, construction, several industries (e.g. foundries) and agriculture. Occupational exposure to silica dust is known to be related to several non-malignant respiratory health effects. In addition respirable crystalline silica has been classified as malignant by the International Agency for Research on Cancer (IARC) since 1997. However, conflicting data has fueled a debate against this classification for the past decade. In the presented study quantitative data on the exposure response relationship between occupational crystalline silica exposure and risk of
lung cancer was evaluated by applying a formal meta regression. Data was collected from studies used in a meta-analysis performed by Lacasse and co-workers in 2009 and more recent studies which reported quantitatively on the relation between crystalline silica and
lung cancer. The main aim was to shed light on the actual shape of the exposure response relation for respirable crystalline silica and
lung cancer. Both a linear and a natural spline model were fitted to the data. The natural spline model fitted the data better and showed a small, but statistically significant (p =0.04) increase in
lung cancer risk resulting from increasing crystalline silica exposure. This increase however was only observed at relatively low levels of cumulative exposure to crystalline silica.
Advisors/Committee Members: Kromhout, H.
Subjects/Keywords: crystalline silica; lung cancer
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APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Breeveld, A. R. (2011). Shape of the exposure response relation for crystalline silica and risk of lung cancer. (Masters Thesis). Universiteit Utrecht. Retrieved from http://dspace.library.uu.nl:8080/handle/1874/209135
Chicago Manual of Style (16th Edition):
Breeveld, A R. “Shape of the exposure response relation for crystalline silica and risk of lung cancer.” 2011. Masters Thesis, Universiteit Utrecht. Accessed February 26, 2021.
http://dspace.library.uu.nl:8080/handle/1874/209135.
MLA Handbook (7th Edition):
Breeveld, A R. “Shape of the exposure response relation for crystalline silica and risk of lung cancer.” 2011. Web. 26 Feb 2021.
Vancouver:
Breeveld AR. Shape of the exposure response relation for crystalline silica and risk of lung cancer. [Internet] [Masters thesis]. Universiteit Utrecht; 2011. [cited 2021 Feb 26].
Available from: http://dspace.library.uu.nl:8080/handle/1874/209135.
Council of Science Editors:
Breeveld AR. Shape of the exposure response relation for crystalline silica and risk of lung cancer. [Masters Thesis]. Universiteit Utrecht; 2011. Available from: http://dspace.library.uu.nl:8080/handle/1874/209135
15.
坪内, 拡伸.
Rikkunshito ameliorates bleomycin-induced acute lung injury in a ghrelin-independent manner : 六君子湯投与はブレオマイシン誘導性急性肺障害をグレリン非依存性に改善する.
Degree: 博士(医学), 2014, University of Miyazaki / 宮崎大学
URL: http://hdl.handle.net/10458/5039
以下に掲載:American Journal of Physiology - Lung Cellular and Molecular Physiology. 2014, 306, 3, p.L233-L245, doi:10.1152/ajplung.00096.2013.
Subjects/Keywords: rikkunshito; acute lung injury; ghrelin
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
坪内, . (2014). Rikkunshito ameliorates bleomycin-induced acute lung injury in a ghrelin-independent manner : 六君子湯投与はブレオマイシン誘導性急性肺障害をグレリン非依存性に改善する. (Thesis). University of Miyazaki / 宮崎大学. Retrieved from http://hdl.handle.net/10458/5039
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
坪内, 拡伸. “Rikkunshito ameliorates bleomycin-induced acute lung injury in a ghrelin-independent manner : 六君子湯投与はブレオマイシン誘導性急性肺障害をグレリン非依存性に改善する.” 2014. Thesis, University of Miyazaki / 宮崎大学. Accessed February 26, 2021.
http://hdl.handle.net/10458/5039.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
坪内, 拡伸. “Rikkunshito ameliorates bleomycin-induced acute lung injury in a ghrelin-independent manner : 六君子湯投与はブレオマイシン誘導性急性肺障害をグレリン非依存性に改善する.” 2014. Web. 26 Feb 2021.
Vancouver:
坪内 . Rikkunshito ameliorates bleomycin-induced acute lung injury in a ghrelin-independent manner : 六君子湯投与はブレオマイシン誘導性急性肺障害をグレリン非依存性に改善する. [Internet] [Thesis]. University of Miyazaki / 宮崎大学; 2014. [cited 2021 Feb 26].
Available from: http://hdl.handle.net/10458/5039.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
坪内 . Rikkunshito ameliorates bleomycin-induced acute lung injury in a ghrelin-independent manner : 六君子湯投与はブレオマイシン誘導性急性肺障害をグレリン非依存性に改善する. [Thesis]. University of Miyazaki / 宮崎大学; 2014. Available from: http://hdl.handle.net/10458/5039
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Alberta
16.
Al-Hallak, MHD Kamal.
Inhalable nanoparticles in lung cancer treatment; efficacy,
safety, distribution and nanoparticle-macrophage
interactions.
Degree: PhD, Faculty of Pharmacy and Pharmaceutical
Sciences, 2012, University of Alberta
URL: https://era.library.ualberta.ca/files/mk61rj53p
► In 2002, lung cancer was responsible for 17.6% of the total worldwide deaths from cancer. Beyond the three traditional forms of cancer treatment, surgery, radiation…
(more)
▼ In 2002, lung cancer was responsible for 17.6% of the
total worldwide deaths from cancer. Beyond the three traditional
forms of cancer treatment, surgery, radiation therapy, and
chemotherapy, targeted drug delivery therapy has shown to be a
potential treatment option. The design of a successful delivery
system requires consideration of many factors, some of which
include (i) the location and main organ(s) affected; (ii) the
complexity of the associated physiological changes; (iii) the
changes in receptor expression in cancerous cells; (iv) the
physiochemical properties of the delivery system; (v) the
interactions between the cancerous cells and other adjuvant cells,
such as macrophages, with the delivery system; and (vi) the safety
and tolerability of the delivery system. Considering the above
factors of a successful delivery system, the aim of the present
work was to design an innovative delivery system for lung cancer
treatment incorporating inhalable nanoparticles (NP). To achieve
this goal, several objectives were developed: (i) to investigate
the interactions of different NP formulations with macrophages and
the resulting effects on the behavior of macrophages; (ii) to
assess and correlate the pulmonary toxicity of inhalable NPs using
in vivo and in vitro methods; (iii) to develop a method to assess
in real-time the effect of the formulation modifications on the
uptake by macrophages of NPs; (iv) to assess the in vivo efficacy
of an innovative formulation of effervescent inhalable NPs, thus
actively releasing NPs; and finally, (v) to investigate the
distribution of effervescent inhalable NPs after pulmonary
delivery. Our results demonstrate that after exposure to NPs,
macrophages undergo cellular changes to gain the ability to produce
Th1 cytokines that are able to affect the viability of cancerous
cells. The tolerability of inhalable NPs was related mainly to the
additives used in the NP formulation. There was a good correlation
between the in vivo and in vitro results. Effervescent inhalable
NPs proved to be an effective and tolerable treatment for lung
cancer treatment. Whole body autoradiography showed that inhalable
NPs were able to achieve deep lung deposition and become
distributed in time over the whole lung with some extra-pulmonary
distribution.
Subjects/Keywords: inhalable nanoparticles; Lung cancer; Macrophages
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APA (6th Edition):
Al-Hallak, M. K. (2012). Inhalable nanoparticles in lung cancer treatment; efficacy,
safety, distribution and nanoparticle-macrophage
interactions. (Doctoral Dissertation). University of Alberta. Retrieved from https://era.library.ualberta.ca/files/mk61rj53p
Chicago Manual of Style (16th Edition):
Al-Hallak, MHD Kamal. “Inhalable nanoparticles in lung cancer treatment; efficacy,
safety, distribution and nanoparticle-macrophage
interactions.” 2012. Doctoral Dissertation, University of Alberta. Accessed February 26, 2021.
https://era.library.ualberta.ca/files/mk61rj53p.
MLA Handbook (7th Edition):
Al-Hallak, MHD Kamal. “Inhalable nanoparticles in lung cancer treatment; efficacy,
safety, distribution and nanoparticle-macrophage
interactions.” 2012. Web. 26 Feb 2021.
Vancouver:
Al-Hallak MK. Inhalable nanoparticles in lung cancer treatment; efficacy,
safety, distribution and nanoparticle-macrophage
interactions. [Internet] [Doctoral dissertation]. University of Alberta; 2012. [cited 2021 Feb 26].
Available from: https://era.library.ualberta.ca/files/mk61rj53p.
Council of Science Editors:
Al-Hallak MK. Inhalable nanoparticles in lung cancer treatment; efficacy,
safety, distribution and nanoparticle-macrophage
interactions. [Doctoral Dissertation]. University of Alberta; 2012. Available from: https://era.library.ualberta.ca/files/mk61rj53p

University of Alberta
17.
Noice, Lori.
A Quantitative Analysis of Four Dimensional Computed
Tomography.
Degree: MS, Physics, 2010, University of Alberta
URL: https://era.library.ualberta.ca/files/0z708x912
► This project assesses the four dimensional computed tomography (4DCT) capabilities of the Philips Brilliance Big Bore CT scanner (Philips Medical Systems, Cleveland, OH). A mechanical…
(more)
▼ This project assesses the four dimensional computed
tomography (4DCT) capabilities of the Philips Brilliance Big Bore
CT scanner (Philips Medical Systems, Cleveland, OH). A mechanical
phantom imparts clinically relevant motions to acrylic spheres of
various diameters. The size, shape, and position of these spheres,
as measured with 4DCT, are compared to their true size, shape, and
position. An evaluation of image quality is also performed. Maximum
discrepancies between physical and imaged volumes, for all sphere
sizes and motion ranges, did not exceed 2.6 mm (mean = 1.2 mm,
standard deviation = 0.4 mm). For approximately tissue equivalent
density objects, mean CT# in 4DCT images differed from those in
standard clinical thoracic images by only a few Hounsfield units.
Measured geometric precision along with the accuracy of mean CT#s
observed in 4DCT phase images indicate that 4DCT is an appropriate
imaging technique for treatment planning.
Subjects/Keywords: 4DCT, CT, lung, motion management
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Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Noice, L. (2010). A Quantitative Analysis of Four Dimensional Computed
Tomography. (Masters Thesis). University of Alberta. Retrieved from https://era.library.ualberta.ca/files/0z708x912
Chicago Manual of Style (16th Edition):
Noice, Lori. “A Quantitative Analysis of Four Dimensional Computed
Tomography.” 2010. Masters Thesis, University of Alberta. Accessed February 26, 2021.
https://era.library.ualberta.ca/files/0z708x912.
MLA Handbook (7th Edition):
Noice, Lori. “A Quantitative Analysis of Four Dimensional Computed
Tomography.” 2010. Web. 26 Feb 2021.
Vancouver:
Noice L. A Quantitative Analysis of Four Dimensional Computed
Tomography. [Internet] [Masters thesis]. University of Alberta; 2010. [cited 2021 Feb 26].
Available from: https://era.library.ualberta.ca/files/0z708x912.
Council of Science Editors:
Noice L. A Quantitative Analysis of Four Dimensional Computed
Tomography. [Masters Thesis]. University of Alberta; 2010. Available from: https://era.library.ualberta.ca/files/0z708x912

Cornell University
18.
Jirapatnakul, Artit.
Computer Methods For Pulmonary Nodule Characterization From Ct Images.
Degree: M.S., Electrical Engineering, Electrical Engineering, 2011, Cornell University
URL: http://hdl.handle.net/1813/29192
► Computed tomography (CT) scans provide radiologists a non-invasive method of imaging internal structures of the body. Although CT scans have enabled the earlier detection of…
(more)
▼ Computed tomography (CT) scans provide radiologists a non-invasive method of imaging internal structures of the body. Although CT scans have enabled the earlier detection of suspicious nodules, these nodules are often small and difficult to accurately classify for radiologists. An automated system was developed to classify a pulmonary nodule based on image features extracted from a single CT scan. Several critical issues related to performance evaluation of such systems were also examined. The image features considered in the system were: statistics from the density distribution, shape, curvature, and boundary features. The shape and density features were computed through moment analysis of the segmented nodule. Local curvature was computed from a triangle-tessellated surface of the nodule; the statistics of the distribution of curvatures were used as features in the system. Finally, the boundary of the nodule was examined to quantify the transition region between the nodule and
lung parenchyma. This was accomplished by combining the grayscale information and 3D model to measure the gradient on the surface of the nodule. These methods resulted in a total of 43 features. For compari- son, 2D features were computed for the density and shape features, resulting in 26 features. Four feature classification schemes were evaluated: logistic regression, k-nearest-neighbors, distance-weighted nearest-neighbors, and support vector machines (SVM). These features and classifiers were validated on a large dataset of 259 nodules. The best performance, an area under the ROC curve (AUC) of 0.702, was achieved using 3D features and the logistic regression classifier. A major consideration when evaluating a nodule classification system is whether the system presents an improvement over a baseline performance. Since the majority of large nodules in many datasets are malignant, the impact of nodule size on the performance of the classification system was examined. This was accomplished by comparing the performance of the system with feature sets that included sizedependent features to feature sets that excluded those features.The performance of size alone, estimated using a size-threshold classifier, was an AUC of 0.653. For the SVM classifier, removing size-dependent features reduced the performance from an AUC of 0.69 to 0.61. To approximate the performance that might be obtained on a dataset without a size bias, a subset of cases was selected where the benign and malignant nodules were of similar sizes. On this subset, size was not a very powerful feature with an AUC of 0.507, and features that were not dependent on size performed better than size-dependent features for SVM, with an AUC of 0.63 compared to 0.52. While other methods have been proposed for performing nodule classification, this is the first study to comprehensively look at the performance impact from datasets with nodules that exhibit a bias in size.
Advisors/Committee Members: Reeves, Anthony P (chair), Doerschuk, Peter (committee member).
Subjects/Keywords: pulmonary nodule; characterization; lung cancer
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Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
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APA (6th Edition):
Jirapatnakul, A. (2011). Computer Methods For Pulmonary Nodule Characterization From Ct Images. (Masters Thesis). Cornell University. Retrieved from http://hdl.handle.net/1813/29192
Chicago Manual of Style (16th Edition):
Jirapatnakul, Artit. “Computer Methods For Pulmonary Nodule Characterization From Ct Images.” 2011. Masters Thesis, Cornell University. Accessed February 26, 2021.
http://hdl.handle.net/1813/29192.
MLA Handbook (7th Edition):
Jirapatnakul, Artit. “Computer Methods For Pulmonary Nodule Characterization From Ct Images.” 2011. Web. 26 Feb 2021.
Vancouver:
Jirapatnakul A. Computer Methods For Pulmonary Nodule Characterization From Ct Images. [Internet] [Masters thesis]. Cornell University; 2011. [cited 2021 Feb 26].
Available from: http://hdl.handle.net/1813/29192.
Council of Science Editors:
Jirapatnakul A. Computer Methods For Pulmonary Nodule Characterization From Ct Images. [Masters Thesis]. Cornell University; 2011. Available from: http://hdl.handle.net/1813/29192

Cornell University
19.
Tang, Wenbo.
The Role Of Genetics, Nutrition, And Cigarette Smoking In The Longitudinal Change In Lung Function.
Degree: PhD, Nutrition, 2013, Cornell University
URL: http://hdl.handle.net/1813/34378
► Lung function is an important predictor of population morbidity and mortality. Decline in lung function is a natural part of aging, but accelerated loss in…
(more)
▼ Lung function is an important predictor of population morbidity and mortality. Decline in
lung function is a natural part of aging, but accelerated loss in
lung function over time is a harbinger of chronic obstructive pulmonary disease (COPD), a leading cause of death globally. Smoking is widely recognized as the key risk factor for reduced
lung function and COPD, although additional risk factors, such as genetics and nutrition, have been suggested to also play important roles in contributing to changes in
lung function. The overall aim of this research was to investigate the role of, and interaction between, genetics, nutrition, and cigarette smoking in relation to the longitudinal change in
lung function, as an indicator of COPD susceptibility. First, we explored the association between genetic variation within a network of antioxidant enzyme genes and the rate of change in
lung function in a prospective cohort study of African and European American elderly adults; this study also investigated gene-bysmoking interaction. Evidence of association was identified for genetic variants in several candidate genes, among which were two novel genes (mGST3 and IDH3B) that interacted with smoking in both races/ethnicities. Second, to expand the scope of investigation to all common genetic variants iii throughout the entire human genome, we conducted a large-scale meta-analysis of genomewide association studies of longitudinal change in
lung function in a consortium of 14 individual cohort studies of adults of European ancestry. We found evidence of association at two novel genetic loci (IL16/STARD5/TMC3 and ME3) in the meta-analysis and performed additional gene expression analyses to demonstrate that both loci harbor candidate genes with biologically plausible functional links to
lung function. Finally, we explored the role of nutrition directly by investigating the relation between overall dietary patterns and longitudinal change in
lung function in a prospective cohort of male adults, considering diet-by-smoking interaction. We identified two distinct dietary patterns by applying principal component analysis to food frequency questionnaire data, and found that a prudent diet rich in fruits, vegetables, fish, and poultry attenuated the accelerated decline in
lung function in cigarette smokers, but had no association in non-smokers. iv
Advisors/Committee Members: Cassano, Patricia Ann (chair), Wells, Martin Timothy (committee member), Clark, Andrew (committee member), Caudill, Marie A. (committee member).
Subjects/Keywords: Lung function; Genetics; Nutrition
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APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Tang, W. (2013). The Role Of Genetics, Nutrition, And Cigarette Smoking In The Longitudinal Change In Lung Function. (Doctoral Dissertation). Cornell University. Retrieved from http://hdl.handle.net/1813/34378
Chicago Manual of Style (16th Edition):
Tang, Wenbo. “The Role Of Genetics, Nutrition, And Cigarette Smoking In The Longitudinal Change In Lung Function.” 2013. Doctoral Dissertation, Cornell University. Accessed February 26, 2021.
http://hdl.handle.net/1813/34378.
MLA Handbook (7th Edition):
Tang, Wenbo. “The Role Of Genetics, Nutrition, And Cigarette Smoking In The Longitudinal Change In Lung Function.” 2013. Web. 26 Feb 2021.
Vancouver:
Tang W. The Role Of Genetics, Nutrition, And Cigarette Smoking In The Longitudinal Change In Lung Function. [Internet] [Doctoral dissertation]. Cornell University; 2013. [cited 2021 Feb 26].
Available from: http://hdl.handle.net/1813/34378.
Council of Science Editors:
Tang W. The Role Of Genetics, Nutrition, And Cigarette Smoking In The Longitudinal Change In Lung Function. [Doctoral Dissertation]. Cornell University; 2013. Available from: http://hdl.handle.net/1813/34378

Vanderbilt University
20.
Samanta, Debangshu.
Long-term smoking-mediated downregulation of Smad3 induces tumorigenicity and carboplatin resistance in non-small cell lung cancer.
Degree: PhD, Cancer Biology, 2012, Vanderbilt University
URL: http://hdl.handle.net/1803/12131
► Inactivating mutations in TGF-©¬ receptors and Smad signal transducers that contribute to resistance to TGF-©¬, are associated with only very small number of NSCLC. The…
(more)
▼ Inactivating mutations in TGF-©¬ receptors and Smad signal transducers that contribute to resistance to TGF-©¬, are associated with only very small number of NSCLC. The Smad dependent pathway is involved in the tumor suppressive functions of TGF-¥â. Epidemiological studies have demonstrated that most cases of
lung cancer (85-90%) are directly attributable to cigarette smoking. However, nothing is known how smoking is involved in inhibiting tumor suppressor functions of TGF-©¬ and whether or how the chemo resistance of platinum-based drugs seen in
lung cancer patients who are smokers is dependent on this pathway. To address this issue,
lung adenocarcinoma A549 and immortalized bronchial epithelial HPL1A cells were chronically treated (300 days) with cigarette smoke condensate (CSC) and Dimethyl sulphoxide (DMSO, as a control) to mimic the conditions of long-term cigarette smoking. Prolonged exposure of these cells to CSC resulted in decreased Smad-mediated TGF-¥â signaling due to reduced expression of Smad3 both in the protein and mRNA level. The decrease in Smad3 is due to histone deacetylation. Long-term CSC treatment reduced apoptosis, increased cell viability, decreased TGF-¥â-mediated growth inhibition, and enhanced tumorigenicity both in vitro and in vivo. Re-expression of Smad3 in the long-term CSC treated cells reversed the cancerous phenotypes observed due to long-term CSC treatment. Looking further into public databases revealed that the expression of Smad3 is lower in
lung tumors of current smokers compared to that observed in never-smokers. The long-term CSC treatment also rendered the cells resistant to platinum-based chemotherapy; by up regulating Bcl2. Blocking the effect of Bcl2 both by small molecule inhibitor ABT-737 and siRNA approaches re-sensitized the cells to platinum-based chemotherapy. The re-expression of exogenous Smad3 in the long-term CSC treated cells, decreased the Bcl2 levels and re-sensitized the cells to platinum-based chemotherapy. Thus, Smad3 controls the expression of Bcl2 and sensitivity to platinum based drugs in our model system. Collectively, these data provide evidence that cigarette smoking promotes tumorigenicity and makes the cells resistant to platinum-based chemotherapy by abrogating apoptosis, partly by reducing expression of Smad3.
Advisors/Committee Members: Pran K. Datta (committee member), Mark deCaestecker (committee member), Lawrence J. Marnett (committee member), David P. Carbone (committee member), Jin Chen (Committee Chair).
Subjects/Keywords: Smoking; Lung cancer; Smad3; Chemoresistance
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Samanta, D. (2012). Long-term smoking-mediated downregulation of Smad3 induces tumorigenicity and carboplatin resistance in non-small cell lung cancer. (Doctoral Dissertation). Vanderbilt University. Retrieved from http://hdl.handle.net/1803/12131
Chicago Manual of Style (16th Edition):
Samanta, Debangshu. “Long-term smoking-mediated downregulation of Smad3 induces tumorigenicity and carboplatin resistance in non-small cell lung cancer.” 2012. Doctoral Dissertation, Vanderbilt University. Accessed February 26, 2021.
http://hdl.handle.net/1803/12131.
MLA Handbook (7th Edition):
Samanta, Debangshu. “Long-term smoking-mediated downregulation of Smad3 induces tumorigenicity and carboplatin resistance in non-small cell lung cancer.” 2012. Web. 26 Feb 2021.
Vancouver:
Samanta D. Long-term smoking-mediated downregulation of Smad3 induces tumorigenicity and carboplatin resistance in non-small cell lung cancer. [Internet] [Doctoral dissertation]. Vanderbilt University; 2012. [cited 2021 Feb 26].
Available from: http://hdl.handle.net/1803/12131.
Council of Science Editors:
Samanta D. Long-term smoking-mediated downregulation of Smad3 induces tumorigenicity and carboplatin resistance in non-small cell lung cancer. [Doctoral Dissertation]. Vanderbilt University; 2012. Available from: http://hdl.handle.net/1803/12131

Vanderbilt University
21.
Meador, Catherine Belle.
Optimizing the sequence of targeted therapy in EGFR-mutant lung adenocarcinoma.
Degree: PhD, Cancer Biology, 2015, Vanderbilt University
URL: http://hdl.handle.net/1803/13334
► EGFR-mutant lung cancers are highly sensitive to EGFR tyrosine kinase inhibitors (TKIs; erlotinib/gefitinib/afatinib), but tumors develop drug resistance within 9-16 months. Resistance to gefitinib/erlotinib commonly…
(more)
▼ EGFR-mutant
lung cancers are highly sensitive to EGFR tyrosine kinase inhibitors (TKIs; erlotinib/gefitinib/afatinib), but tumors develop drug resistance within 9-16 months. Resistance to gefitinib/erlotinib commonly occurs via a second-site EGFR mutation, T790M. Two strategies to overcome T790M+ resistance are mutant-specific EGFR TKIs, such as AZD9291, and dual inhibition of EGFR with afatinib plus the anti-EGFR antibody, cetuximab (A+C). Unfortunately, ‘second-line’ acquired resistance to A+C and AZD9291, after ‘first-line’ acquired resistance to erlotinib/gefitinib/afatinib, also occurs. To prevent/delay resistance to AZD9291, the combination of AZD9291 plus selumetinib (MEK1/2 inhibitor; AZD6244/ARRY-142886) is also currently being tested in a Phase I clinical trial (NCT02143466). The effects of sequential and combination treatment with various anti-EGFR agents on tumor evolution and drug resistance are largely unknown. In these studies, we modeled drug resistance pre-clinically to: 1. Assess the heterogeneity of mechanisms of first-line resistance to erlotinib and afatinib 2. Determine the optimum order of treatment with A+C vs. AZD9291 in the setting of T790M+ EGFR-mutant
lung tumors 3. Elucidate mechanisms of first- and second-line acquired resistance to AZD9291 and 4. Elucidate mechanisms of resistance to AZD9291 plus selumetinib. Next-generation sequencing of genomic DNA from cell line models of resistance to erlotinib/afatinib revealed multiple potentially functional genomic changes within a given pool of resistant cells (including T790M). We also found that AZD9291 is more potent than A+C at inhibiting cell growth in the setting of T790M+ resistance to erlotinib. A+C-resistant cell lines remain sensitive to AZD9291, but AZD9291-resistant cell lines are cross-resistant to A+C. Resistance to AZD9291 is associated with dysregulation of MAPK signaling and can be overcome by addition of the MEK 1/2 inhibitor, selumetinib. Finally, AZD9291 plus selumetinib-resistant cell lines display increased baseline phospho-MEK/ERK and are sensitive to in vitro treatment with an ERK inhibitor, SCH772984 or alternative MEK inhibitor, trametinib. These studies provide a more comprehensive understanding of how EGFR-mutant tumors undergo rewiring of their signaling circuitry in response to single-agent EGFR- and combined EGFR+MEK-inhibition. This work, emphasizing a mechanistic understanding of the effects of therapies on tumor evolution, provides a framework for future clinical trials testing different treatment sequences.
Advisors/Committee Members: Christine Lovly (committee member), Jennifer Pietenpol (committee member), William Pao (committee member), Rebecca Cook (Committee Chair).
Subjects/Keywords: targeted therapy; EGFR; lung cancer
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APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Meador, C. B. (2015). Optimizing the sequence of targeted therapy in EGFR-mutant lung adenocarcinoma. (Doctoral Dissertation). Vanderbilt University. Retrieved from http://hdl.handle.net/1803/13334
Chicago Manual of Style (16th Edition):
Meador, Catherine Belle. “Optimizing the sequence of targeted therapy in EGFR-mutant lung adenocarcinoma.” 2015. Doctoral Dissertation, Vanderbilt University. Accessed February 26, 2021.
http://hdl.handle.net/1803/13334.
MLA Handbook (7th Edition):
Meador, Catherine Belle. “Optimizing the sequence of targeted therapy in EGFR-mutant lung adenocarcinoma.” 2015. Web. 26 Feb 2021.
Vancouver:
Meador CB. Optimizing the sequence of targeted therapy in EGFR-mutant lung adenocarcinoma. [Internet] [Doctoral dissertation]. Vanderbilt University; 2015. [cited 2021 Feb 26].
Available from: http://hdl.handle.net/1803/13334.
Council of Science Editors:
Meador CB. Optimizing the sequence of targeted therapy in EGFR-mutant lung adenocarcinoma. [Doctoral Dissertation]. Vanderbilt University; 2015. Available from: http://hdl.handle.net/1803/13334

Texas A&M University
22.
Partouche Sebban, Julien 1978-.
Clinical Implementation of Hypofractionated Radiation therapy for Lung Malignancies.
Degree: PhD, Nuclear Engineering, 2012, Texas A&M University
URL: http://hdl.handle.net/1969.1/157710
► For patients with oligometastases, metastases limited in number and site, the use of radiation therapy treatment with a hypofractionated dose scheme has been proposed as…
(more)
▼ For patients with oligometastases, metastases limited in number and site, the use of radiation therapy treatment with a hypofractionated dose scheme has been proposed as a potential ablative approach. There are a limited number of prospective studies looking at hypofractionated radiation therapy (HRT) for
lung oligometastasis. Normal
lung tissue complication and radiation planning technique are significant limiting factors for the implementation of hypofractionated
lung metastasis. The problem statement of this study is how to improve the clinical implementation of HRT for
lung metastasis exploring
lung toxicity predictors, and developing an efficient radiation planning method.
In the first study, we analyzed the dose distribution for 28 patients with
lung oligometastasis and treated with HRT to multiple metastases in the lungs. We identified several significant predictors for
lung radiation pneumonitis (RP) including the mean
lung dose (MLD), V13 and V20. In addition a dose-effect relation between the
lung normalized total dose (NTD) and RP may exist up to 48 Gy in three fractions. The dose-response parameters derived in our study appear to agree with other hypofractionated results published in the literature.
In the second study, we used an inverse planning algorithm to develop a new radiation planning method by limiting the number of segments per beam angle down to 1 segment. Single segment plans were able to significantly improve tumor coverage and conformality, reduce the risk of
lung RP, while simplifying the planning process and delivery. Target conformality and normal
lung tissue sparing did not gain much improvement from an increase of plan complexity to five segments over the simplified one segment technique. The automation of our method is a good alternative to more traditional methods and offers significant dosimetric benefits.
In the third study, we verified the single segment planning technique via patient specific quality assurance (QA) in a motion phantom. We found good agreement between calculated and measured doses via thermoluminescent detectors (TLD) inside the target. A dose to distance agreement of 3%/3 mm and 2%/2 mm between calculation and film measurements for representative plans in a motion phantom was verified at 98.99% and 97.15%, respectively.
Advisors/Committee Members: Ford, John R (advisor), Poston, John W (committee member), Braby, Leslie A (committee member), Walker, Michael (committee member).
Subjects/Keywords: radiation therapy; lung; hypofractionated
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APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Partouche Sebban, J. 1. (2012). Clinical Implementation of Hypofractionated Radiation therapy for Lung Malignancies. (Doctoral Dissertation). Texas A&M University. Retrieved from http://hdl.handle.net/1969.1/157710
Chicago Manual of Style (16th Edition):
Partouche Sebban, Julien 1978-. “Clinical Implementation of Hypofractionated Radiation therapy for Lung Malignancies.” 2012. Doctoral Dissertation, Texas A&M University. Accessed February 26, 2021.
http://hdl.handle.net/1969.1/157710.
MLA Handbook (7th Edition):
Partouche Sebban, Julien 1978-. “Clinical Implementation of Hypofractionated Radiation therapy for Lung Malignancies.” 2012. Web. 26 Feb 2021.
Vancouver:
Partouche Sebban J1. Clinical Implementation of Hypofractionated Radiation therapy for Lung Malignancies. [Internet] [Doctoral dissertation]. Texas A&M University; 2012. [cited 2021 Feb 26].
Available from: http://hdl.handle.net/1969.1/157710.
Council of Science Editors:
Partouche Sebban J1. Clinical Implementation of Hypofractionated Radiation therapy for Lung Malignancies. [Doctoral Dissertation]. Texas A&M University; 2012. Available from: http://hdl.handle.net/1969.1/157710

Penn State University
23.
Crampsie, Melissa Ashley.
INVESTIGATION OF THE MECHANISM OF ACTION OF ISOTHIOCYANATE
DERIVED ISOSELENOCYANATES AND THE CHEMOPREVENTIVE POTENTIAL OF
PHENYLBUTYL ISOSELENOCYANATE
.
Degree: 2011, Penn State University
URL: https://submit-etda.libraries.psu.edu/catalog/12391
► Goals of Dissertation Research Lung cancer is currently the leading cause of cancer deaths among men and women and has a survival rate of only…
(more)
▼ Goals of Dissertation Research
Lung cancer is currently the leading cause of cancer deaths among men and women and has a survival rate of only 16%. Because nearly 90% of
lung cancer cases are attributed to smoking tobacco and tobacco related
lung cancer has a latency period of 20-30 years from time of exposure to invasive disease, intervention before invasive disease with a chemical agent, termed chemoprevention, is a well suited approach for this particular disease. Research suggests that many natural compounds, often found in the human diet, have chemopreventive properties and are actively being explored and/or can make excellent lead compounds. Our lab, using rational drug design techniques, developed a novel isoselenocyanate compound known as phenylbutyl isoselenocyanate (ISC-4) based on naturally occurring compounds found in cruciferous vegetables. The central hypothesis of this research was that ISC-4, based on its design, would function as a potent and effective anti-cancer agent and could be used as a chemopreventive agent.
Specific Aims
Specific Aim 1: To determine the effects of replacing the sulfur atom of a panel of phenyl alkyl isothiocyanates with selenium to form a new panel of phenyl alkyl isoselenocyanates (Chapter 2). A structure activity study was performed on the panel of parent isothiocyanate compounds and the resulting panel of isoselenocyanate compounds to determine if mechanistic characteristics were retained and to ascertain a reason for increased activity.
Specific Aim 2: Testing the hypothesis that ISC-4 has potential as a chemopreventive agent (Chapter 3). This drug was found to potently target and inhibit carcinogen bioactivation by cytochrome P450 enzymes, including the tobacco specific nitrosamine procarcinogen, N-nitrosyl ketone (NNK). When bioactivated, NNK can lead to mutations in DNA and ultimately result in tumorigenesis. A series of experiments were conducted to assess chemopreventive properties including bioavailability, anti-initiation, and DNA adduct studies, all of which were needed as proof of concept before performing an animal bioassay.
Specific Aim 3: Testing ISC-4 as a chemopreventive agent in a
lung cancer chemoprevention bioassay (Chapter 4). Using an A/J mouse model, ISC-4 at varying doses and along with its sulfur analog PBITC were tested for the ability to inhibit NNK induced
lung tumorigenesis over a 24 week period of time.
Original Breakthroughs and Findings
Isoselenocyanate (ISC) compounds were actually found to have increased activity with cellular thiols compared to their corresponding sulfur analogs leading to the hypothesis that specific protein modifications and redox activity in the cell are responsible for the increased activities seen with the ISC compounds. As Phase I cytochrome P450s were identified early as a significant protein target of ISC-4, the cancer chemopreventive properties of this compound were explored. ISC-4 was found to be orally bioavailable, able to transcriptionally induce Phase II detoxification enzymes, and inhibit DNA adduct…
Advisors/Committee Members: Shantu G Amin, Dissertation Advisor/Co-Advisor, Shantu G Amin, Committee Chair/Co-Chair, Arun Kumar Sharma, Committee Chair/Co-Chair, Kelly J Karpa, Committee Member, Bogdan Prokopczyk, Committee Member, Gary H Perdew, Committee Member, Richard Robert Young, Committee Member.
Subjects/Keywords: ISC-4; lung cancer; chemoprevention
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APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Crampsie, M. A. (2011). INVESTIGATION OF THE MECHANISM OF ACTION OF ISOTHIOCYANATE
DERIVED ISOSELENOCYANATES AND THE CHEMOPREVENTIVE POTENTIAL OF
PHENYLBUTYL ISOSELENOCYANATE
. (Thesis). Penn State University. Retrieved from https://submit-etda.libraries.psu.edu/catalog/12391
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Crampsie, Melissa Ashley. “INVESTIGATION OF THE MECHANISM OF ACTION OF ISOTHIOCYANATE
DERIVED ISOSELENOCYANATES AND THE CHEMOPREVENTIVE POTENTIAL OF
PHENYLBUTYL ISOSELENOCYANATE
.” 2011. Thesis, Penn State University. Accessed February 26, 2021.
https://submit-etda.libraries.psu.edu/catalog/12391.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Crampsie, Melissa Ashley. “INVESTIGATION OF THE MECHANISM OF ACTION OF ISOTHIOCYANATE
DERIVED ISOSELENOCYANATES AND THE CHEMOPREVENTIVE POTENTIAL OF
PHENYLBUTYL ISOSELENOCYANATE
.” 2011. Web. 26 Feb 2021.
Vancouver:
Crampsie MA. INVESTIGATION OF THE MECHANISM OF ACTION OF ISOTHIOCYANATE
DERIVED ISOSELENOCYANATES AND THE CHEMOPREVENTIVE POTENTIAL OF
PHENYLBUTYL ISOSELENOCYANATE
. [Internet] [Thesis]. Penn State University; 2011. [cited 2021 Feb 26].
Available from: https://submit-etda.libraries.psu.edu/catalog/12391.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Crampsie MA. INVESTIGATION OF THE MECHANISM OF ACTION OF ISOTHIOCYANATE
DERIVED ISOSELENOCYANATES AND THE CHEMOPREVENTIVE POTENTIAL OF
PHENYLBUTYL ISOSELENOCYANATE
. [Thesis]. Penn State University; 2011. Available from: https://submit-etda.libraries.psu.edu/catalog/12391
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Texas Southwestern Medical Center
24.
Patrick, David M.
Regulation of Cellular Growth and Differentiation by MicroRNAs -21 and -451.
Degree: 2013, University of Texas Southwestern Medical Center
URL: http://hdl.handle.net/2152.5/1705
► MicroRNAs are small RNAs approximately 20-24 nucleotides in length that are conserved throughout evolution. MicroRNA genes are transcribed by RNA polymerase II and are processed…
(more)
▼ MicroRNAs are small RNAs approximately 20-24 nucleotides in length that are conserved throughout evolution. MicroRNA genes are transcribed by RNA polymerase II and are processed both in the nucleus and the cytoplasm from longer precursor RNAs. Functionally, microRNAs interact with Argonaute proteins and guide the formation of a complex with messenger RNAs by Watson-Crick base-pair formation between the microRNA and mRNA. This association stimulates the formation of the microRNA-RNA-induced silencing complex which, upon association with essential adaptor molecules such as GW182, recruits transcriptional repressors and mRNA destabilizers. Essential developmental processes such as embryonic stem cell differentiation and cardiovascular development have been shown to be dependent upon microRNAs. MicroRNAs also participate in a variety of disease processes including tumorigenesis and cardiovascular disease.
MicroRNA-451 (miR-451) is regulated during erythrocyte terminal differentiation. The expression of miR-451 is restricted to late erythrocyte precursors and terminally differentiated erythrocytes. We therefore hypothesized that miR-451 plays a role in terminal erythroid differentiation. Deletion of miR-451 in mice results in a terminal erythroid differentiation defect both embryonically and in adulthood. These animals display a reduction in hematocrit and an inability to sustain a high erythropoietic rate. Transient inhibition of miR-451 results in the same defect. Transcript profiling of miR-451-/- erythroblasts revealed upregulation of 14-3-3ξ, a molecule implicated in the regulation of hematopoiesis. Knockdown of 14-3-3ξ with shRNA in miR-451-/- erythroblasts attenuates the differentiation defect. These data show the essential role of miR-451 repression of 14-3-3ξ during terminal erythrocyte differentiation. Finally, the potent effect of miR-451 inhibition on erythrocyte production suggests that this strategy may be efficacious for the treatment of polycythemia vera, a myeloproliferative neoplasm characterzed by excessive erythrocyte production. Inhibition of miR-451 in a mouse model of PV significantly reduces disease burden.
MicroRNA-21 (miR-21) is regulated in a variety of both human and mouse models of disease. MiR-21 has been widely reported as a driver of tumorigenesis and is consistently upregulated in cardiac remodeling. It has been suggested that miR-21 plays a protective role during cardiac hypertrophy, however, an opposing report suggests that miR-21 inhibition is beneficial in a mouse model of cardiac remodeling. We therefore hypothesized that miR-21 played an essential role in cardiac hypertrophy and remodeling. Deletion of miR-21 in mice resulted in no observable phenotype. MiR-21-/- displayed cardiac remodeling, cardiac stress-responsive gene activation, and reduction in cardiac function in response to four cardiac stress models: thoracic aortic constriction, angiotensin II infusion, calcineurin overexpression, and myocardial infarction. Moreover, inhibition of miR-21 with an LNA-modified miR-21…
Advisors/Committee Members: Olson, Eric N., MacDonald, Raymond J., Hill, Joseph A., Johnson, Jane E., Huang, Lily.
Subjects/Keywords: Lung Neoplasms; MicroRNAs; Polycythemia Vera
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Patrick, D. M. (2013). Regulation of Cellular Growth and Differentiation by MicroRNAs -21 and -451. (Thesis). University of Texas Southwestern Medical Center. Retrieved from http://hdl.handle.net/2152.5/1705
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Patrick, David M. “Regulation of Cellular Growth and Differentiation by MicroRNAs -21 and -451.” 2013. Thesis, University of Texas Southwestern Medical Center. Accessed February 26, 2021.
http://hdl.handle.net/2152.5/1705.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Patrick, David M. “Regulation of Cellular Growth and Differentiation by MicroRNAs -21 and -451.” 2013. Web. 26 Feb 2021.
Vancouver:
Patrick DM. Regulation of Cellular Growth and Differentiation by MicroRNAs -21 and -451. [Internet] [Thesis]. University of Texas Southwestern Medical Center; 2013. [cited 2021 Feb 26].
Available from: http://hdl.handle.net/2152.5/1705.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Patrick DM. Regulation of Cellular Growth and Differentiation by MicroRNAs -21 and -451. [Thesis]. University of Texas Southwestern Medical Center; 2013. Available from: http://hdl.handle.net/2152.5/1705
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Texas Southwestern Medical Center
25.
Thomas, Anna Johnson.
Engagement in Care among Patients with Lung Cancer.
Degree: 2016, University of Texas Southwestern Medical Center
URL: http://hdl.handle.net/2152.5/5746
► BACKGROUND: Engagement in care broadly refers to patients' knowledge, skills, ability and willingness to play an active role in their health. Patient activation is a…
(more)
▼ BACKGROUND: Engagement in care broadly refers to patients' knowledge, skills, ability and willingness to play an active role in their health. Patient activation is a core component of engagement and has been associated with better care outcomes in several chronic health populations. Despite these findings, patient activation has been understudied in oncology populations broadly, with little focus on
lung cancer patients specifically.
OBJECTIVE: The primary aim of this study was to describe patient activation among surveyed
lung cancer patients. A second aim was to explore specific demographic, smoking-related, and psychosocial correlates of patient activation.
METHOD: The sample included 231
lung patients who participated in a cross-sectional, multisite study. Patients completed a patient activation self-report instrument, along with demographic, clinical, and psychosocial measures.
ANALYSIS: Data related to study aims were analyzed using univariate and multivariable analysis.
RESULTS: Among
lung cancer patients, overall patient activation scores were significantly lower for current smokers compared to former and never smokers (F (2, 218) = 4.50, p = 0.01), for men when compared with women (F (1, 220) = 8.75, p < 0.01), and for those who reported clinically significant depressive symptoms when compared with those who did not (F (1, 219) = 13.95, p < 0.001). In multivariable analysis, these significant main effects of smoking status, gender, and depressive symptoms remained.
DISCUSSION: Among
lung cancer patients, those who were current smokers, were male, and those who endorsed high depressive symptomatology were likely to have the lowest activation scores in the sample. Practical recommendations include clinically identifying these high-risk patients through assessment and addressing activation via evidence based intervention.
Advisors/Committee Members: Hamann, Heidi, Kendall, Jeffrey, Germann, Julie, Howe-Martin, Laura, Whitfill, Travis.
Subjects/Keywords: Depression; Lung Neoplasms; Patient Participation
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APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Thomas, A. J. (2016). Engagement in Care among Patients with Lung Cancer. (Thesis). University of Texas Southwestern Medical Center. Retrieved from http://hdl.handle.net/2152.5/5746
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Thomas, Anna Johnson. “Engagement in Care among Patients with Lung Cancer.” 2016. Thesis, University of Texas Southwestern Medical Center. Accessed February 26, 2021.
http://hdl.handle.net/2152.5/5746.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Thomas, Anna Johnson. “Engagement in Care among Patients with Lung Cancer.” 2016. Web. 26 Feb 2021.
Vancouver:
Thomas AJ. Engagement in Care among Patients with Lung Cancer. [Internet] [Thesis]. University of Texas Southwestern Medical Center; 2016. [cited 2021 Feb 26].
Available from: http://hdl.handle.net/2152.5/5746.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Thomas AJ. Engagement in Care among Patients with Lung Cancer. [Thesis]. University of Texas Southwestern Medical Center; 2016. Available from: http://hdl.handle.net/2152.5/5746
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

North Carolina State University
26.
Cesta, Mark Francis.
Contribution of Bacterial Lipopolysaccharide to Carbon Nanotube- and Vanadium Pentoxide-Induced Pulmonary Fibrosis in Rats.
Degree: PhD, Comparative Biomedical Sciences, 2010, North Carolina State University
URL: http://www.lib.ncsu.edu/resolver/1840.16/6162
► Pulmonary fibrosis is typically accompanied by inflammation, which is thought to play a role in its pathogenesis, and occurs with occupational exposure to particulates and…
(more)
▼ Pulmonary fibrosis is typically accompanied by inflammation, which is thought to play a role in its pathogenesis, and occurs with occupational exposure to particulates and metals, such as asbestos and vanadium pentoxide (V2O5). Lipopolysaccharide (LPS), a model of acute
lung injury and inflammation, chronic bronchitis, and pulmonary fibrosis, upregulates platelet-derived growth factor receptor (PDGF-Rα) in rat
lung fibroblasts (RLF). PDGF, a potent mitogen and chemoattractant for mesenchymal cells, is an important mediator in fibrotic
lung diseases. This dissertation examines the effects of pre-existing inflammation, induced by LPS, on carbon nanotube (CNT)- and V2O5-induced pulmonary fibrosis in rats and the involvement of PDGF signaling. Rats were pretreated with 2.5 mg/kg LPS by intranasal aspiration, followed 24 hr later by 4 mg /kg CNT, carbon black (CB), or V2O5 administered by intratracheal instillation. Total and differential cell counts, lactate dehydrogenase (LDH), total protein, and PDGF and transforming growth factor-β (TGF-β) protein levels (by ELISA) were examined in bronchoalveolar lavage (BAL) fluid of control and CB- and MWCNT –exposed rats. Lungs from all animals were collected for histopathological analysis, immunohistochemistry, and qPCR of the Pdgf-a, Pdgf-c, Pdgf-rα, and Tgf-β genes. Pdgf-a, Pdgf-c, Pdgf-rα, Tgf-β, and Col1a2 gene expression was also measured in vitro in RLF and NR8383 rat alveolar macrophages in response to CNT or CB with and without LPS. In vivo, CNT and CB caused fibroproliferative, granulomatous lesions, which were located primarily in the alveolar ducts and alveoli. Pretreatment with LPS significantly increased collagen deposition associated with these lesions. In the BAL fluid, LPS pretreatment lead to increases in LDH, total protein, and PDGF-AA protein in rats exposed to MWCNT, and an increase in inflammatory cells in CB-exposed rats compared to controls. In vitro, LPS stimulated Pdgf-rα gene expression in RLF, and LPS and nanoparticles synergistically increased Pdgf-a expression in NR8383 cells. Combined LPS/V2O5 exposure augmented V2O5-induced pulmonary inflammation, airway epithelial necrosis, and fibrosis and amplified in vivo collagen gene expression. The airway lesions were of particular interest because LPS pretreatment increased the incidence of bronchiolitis obliterans-like lesions, including subepithelial fibrosis and intraluminal fibrotic polyps. These data confirm that LPS pretreatment augments the fibrotic effects of CNT and V2O5 in rats, which likely involves enhanced PDGF signaling. This dissertation provides evidence that pre-existing pulmonary inflammation, as occurs with chronic obstructive pulmonary diseases or cigarette smoking, can enhance pulmonary fibrotic responses to environmental agents. Furthermore, exposure to environmental LPS may play a role in the pathogenesis of some fibrotic
lung diseases.
Advisors/Committee Members: Dr. James C. Bonner, Committee Co-Chair (advisor), Dr. David E. Malarkey, Committee Member (advisor), Dr. Kenneth B. Adler, Committee Member (advisor), Dr. Philip L. Sannes, Committee Chair (advisor).
Subjects/Keywords: lung; lipoplysaccharide; nanotube; vanadium; fibrosis
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Cesta, M. F. (2010). Contribution of Bacterial Lipopolysaccharide to Carbon Nanotube- and Vanadium Pentoxide-Induced Pulmonary Fibrosis in Rats. (Doctoral Dissertation). North Carolina State University. Retrieved from http://www.lib.ncsu.edu/resolver/1840.16/6162
Chicago Manual of Style (16th Edition):
Cesta, Mark Francis. “Contribution of Bacterial Lipopolysaccharide to Carbon Nanotube- and Vanadium Pentoxide-Induced Pulmonary Fibrosis in Rats.” 2010. Doctoral Dissertation, North Carolina State University. Accessed February 26, 2021.
http://www.lib.ncsu.edu/resolver/1840.16/6162.
MLA Handbook (7th Edition):
Cesta, Mark Francis. “Contribution of Bacterial Lipopolysaccharide to Carbon Nanotube- and Vanadium Pentoxide-Induced Pulmonary Fibrosis in Rats.” 2010. Web. 26 Feb 2021.
Vancouver:
Cesta MF. Contribution of Bacterial Lipopolysaccharide to Carbon Nanotube- and Vanadium Pentoxide-Induced Pulmonary Fibrosis in Rats. [Internet] [Doctoral dissertation]. North Carolina State University; 2010. [cited 2021 Feb 26].
Available from: http://www.lib.ncsu.edu/resolver/1840.16/6162.
Council of Science Editors:
Cesta MF. Contribution of Bacterial Lipopolysaccharide to Carbon Nanotube- and Vanadium Pentoxide-Induced Pulmonary Fibrosis in Rats. [Doctoral Dissertation]. North Carolina State University; 2010. Available from: http://www.lib.ncsu.edu/resolver/1840.16/6162

University of Toronto
27.
Babaev, Arkady.
The Effect of Red Blood Cell-derived Lipids on Epithelial and Endothelial Injury.
Degree: 2015, University of Toronto
URL: http://hdl.handle.net/1807/69581
► Transfusion-related acute lung injury (TRALI) is a major complication resulting from transfusion and the leading cause of transfusion-related fatalities. In recent years, focus has shifted…
(more)
▼ Transfusion-related acute lung injury (TRALI) is a major complication resulting from transfusion and the leading cause of transfusion-related fatalities. In recent years, focus has shifted from the antibody-mediated pathogenesis narrative to the role played by stored red blood cell (RBC)-derived breakdown components on acute lung injury. Existing evidence on the harms of RBC-derived oxidized lipids encouraged closer investigation into their role in TRALI. Herein we designed an in-vitro model to test epithelial and endothelial injury caused by RBC-derived lipid 5(S)-hydroxy-6,8,11,14-eicosatetraenoic acid (5-HETE) and its metabolite 5-oxo-6,8,11,14-eicosatetraenoic acid (5-oxoETE) by assessing cytotoxicity, apoptosis, and inflammation with and without treatment with oxoeicosanoid receptor 1 (OXE) antagonist, Gue1654. Our results showed that 0.5 µM 5-oxoETE and 5-HETE have cytotoxic, apoptotic, and pro-inflammatory effects on lung epithelial and endothelial cells following 8-hour stimulation mediated via lipid-OXE receptor complex. We reported herein that Gue1654 can inhibit the RBC-derived lipid-induced epithelial and endothelial cell injury.
M.Sc.
Advisors/Committee Members: Zhang, Haibo, Hare, Gregory M.T., Physiology.
Subjects/Keywords: Injury; Lung; RBC; TRALI; 0719
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Babaev, A. (2015). The Effect of Red Blood Cell-derived Lipids on Epithelial and Endothelial Injury. (Masters Thesis). University of Toronto. Retrieved from http://hdl.handle.net/1807/69581
Chicago Manual of Style (16th Edition):
Babaev, Arkady. “The Effect of Red Blood Cell-derived Lipids on Epithelial and Endothelial Injury.” 2015. Masters Thesis, University of Toronto. Accessed February 26, 2021.
http://hdl.handle.net/1807/69581.
MLA Handbook (7th Edition):
Babaev, Arkady. “The Effect of Red Blood Cell-derived Lipids on Epithelial and Endothelial Injury.” 2015. Web. 26 Feb 2021.
Vancouver:
Babaev A. The Effect of Red Blood Cell-derived Lipids on Epithelial and Endothelial Injury. [Internet] [Masters thesis]. University of Toronto; 2015. [cited 2021 Feb 26].
Available from: http://hdl.handle.net/1807/69581.
Council of Science Editors:
Babaev A. The Effect of Red Blood Cell-derived Lipids on Epithelial and Endothelial Injury. [Masters Thesis]. University of Toronto; 2015. Available from: http://hdl.handle.net/1807/69581

University of Toronto
28.
Frost, Geoffrey.
The Effect of Rotation on the Decellularization of Porcine Lungs.
Degree: 2012, University of Toronto
URL: http://hdl.handle.net/1807/33422
► This thesis examines the challenges of decellularizing porcine lungs. The thesis identifies hydrostatic pressure and the role it plays in perfusate distribution within the lung…
(more)
▼ This thesis examines the challenges of decellularizing porcine lungs. The thesis identifies hydrostatic pressure and the role it plays in perfusate distribution within the lung as a potential roadblock for the decellularization of porcine lungs. The thesis examines methods for mitigating the affect of hydrostatic pressure on the decellularization of porcine lungs. Specifically, the thesis details the design and construction of a vessel that rotates lungs during decellularization. This rotating vessel is evaluated in comparison to two other, non-rotation based, decellularization methods. The rotation device is found to more extensively decellularize the lung than either of the other two options. The thesis concludes by examining what other areas of work could be conducted in this field.
MAST
Advisors/Committee Members: Waddell, Thomas K., Biomedical Engineering.
Subjects/Keywords: Decellularization; Lung; Porcine; Rotation; 0541
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APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Frost, G. (2012). The Effect of Rotation on the Decellularization of Porcine Lungs. (Masters Thesis). University of Toronto. Retrieved from http://hdl.handle.net/1807/33422
Chicago Manual of Style (16th Edition):
Frost, Geoffrey. “The Effect of Rotation on the Decellularization of Porcine Lungs.” 2012. Masters Thesis, University of Toronto. Accessed February 26, 2021.
http://hdl.handle.net/1807/33422.
MLA Handbook (7th Edition):
Frost, Geoffrey. “The Effect of Rotation on the Decellularization of Porcine Lungs.” 2012. Web. 26 Feb 2021.
Vancouver:
Frost G. The Effect of Rotation on the Decellularization of Porcine Lungs. [Internet] [Masters thesis]. University of Toronto; 2012. [cited 2021 Feb 26].
Available from: http://hdl.handle.net/1807/33422.
Council of Science Editors:
Frost G. The Effect of Rotation on the Decellularization of Porcine Lungs. [Masters Thesis]. University of Toronto; 2012. Available from: http://hdl.handle.net/1807/33422

University of Guelph
29.
ter Woort, Federica.
Histologic Evaluation of the Lung in Actively Racing Horses.
Degree: Doctor of Veterinary Science, Department of Clinical Studies, 2012, University of Guelph
URL: https://atrium.lib.uoguelph.ca/xmlui/handle/10214/3910
► Inflammatory Airway Disease has been reported in young racehorses worldwide. The aim of this study was to determine the prevalence of airway inflammation in an…
(more)
▼ Inflammatory Airway Disease has been reported in young racehorses worldwide. The aim of this study was to determine the prevalence of airway inflammation in an actively racing population of horses and to describe and quantify the degree of
lung lesions in this population of horses. The Ontario Death Registry program provided a unique opportunity to evaluate the lungs of actively racing horses that died or were euthanized due to catastrophic injuries while racing or training.
Lung sections of 95 horses were included in the study and evaluated using a previously validated histological airway scoring system. Additionally, staining with Toluidine blue and immunohistochemical labeling was performed on a subset of horses to further characterize the inflammation. Inflammatory cell infiltration, smooth muscle hyperplasia and hemosiderin were commonly found. The airway lesion scores were significantly higher in the caudal and dorsal sections of the lungs than in other areas. There was no correlation between the individual scores and either breed, sex, age, cause of death or performance index. The inflammatory and smooth muscle scores were normally distributed and the hemosiderin score was not. The inflammatory cell infiltration was composed of mononuclear cells, with increased number of mast cells and eosinophils in 3/20 and 12/95 horses respectively. Immunohistochemical labeling showed the inflammation around the airway to be composed of 41.0% CD3-positive T cells and 5.8% CD79a-positive B cells. In addition to the airway findings, inflammatory cell aggregates were observed around the pulmonary blood vessels and in the alveolar septa in 67/95 and 71/95 horses respectively. In conclusion, this study provides a histologic evaluation of a population of actively racing horses in which airway inflammation is a common finding.
Advisors/Committee Members: Viel, Laurent (advisor).
Subjects/Keywords: Racing; Horse; Histology; lung; inflammation
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
ter Woort, F. (2012). Histologic Evaluation of the Lung in Actively Racing Horses. (Doctoral Dissertation). University of Guelph. Retrieved from https://atrium.lib.uoguelph.ca/xmlui/handle/10214/3910
Chicago Manual of Style (16th Edition):
ter Woort, Federica. “Histologic Evaluation of the Lung in Actively Racing Horses.” 2012. Doctoral Dissertation, University of Guelph. Accessed February 26, 2021.
https://atrium.lib.uoguelph.ca/xmlui/handle/10214/3910.
MLA Handbook (7th Edition):
ter Woort, Federica. “Histologic Evaluation of the Lung in Actively Racing Horses.” 2012. Web. 26 Feb 2021.
Vancouver:
ter Woort F. Histologic Evaluation of the Lung in Actively Racing Horses. [Internet] [Doctoral dissertation]. University of Guelph; 2012. [cited 2021 Feb 26].
Available from: https://atrium.lib.uoguelph.ca/xmlui/handle/10214/3910.
Council of Science Editors:
ter Woort F. Histologic Evaluation of the Lung in Actively Racing Horses. [Doctoral Dissertation]. University of Guelph; 2012. Available from: https://atrium.lib.uoguelph.ca/xmlui/handle/10214/3910

University of Illinois – Chicago
30.
Chen, Jr-Shin.
Improved Lung Nodules Detection with Active Contour Method and Machine Learning Based Classification.
Degree: 2015, University of Illinois – Chicago
URL: http://hdl.handle.net/10027/19404
► Computed tomography (CT) scan is one of the widely used medical diagnostic procedures to generate section images of the lung. CT scan employs computer-processed X-rays…
(more)
▼ Computed tomography (CT) scan is one of the widely used medical diagnostic procedures to generate section images of the
lung. CT scan employs computer-processed X-rays that rotates around the patient’s body, and stacks the tomographic images in three dimensional (3D) form for an easier identification of abnormalities. Due to the high mortality rate from
lung cancer, CT scan alone may be insufficient for early detection of
lung nodules.
In order to improve detection accuracy, we propose a Computer Aided Detection (CAD) system to identify
lung nodules. The system uses active contour method to build three-dimensional model from the scans. Then we can get the 3D
lung model without trachea, bronchus, and nodules. By using the reversed out 3D model and threshold method, we can have the 3D models of trachea, bronchus, and nodules. To identify the nodules from the others, we use machine learning method to classify the features from the 3D modules. The proposed system shows 72.22% sensitivity for nodule within 8mm to 90mm with 0.16 false positive per dataset
Advisors/Committee Members: Lu, Hui (advisor), Magin, Richard (committee member), Dai, Yang (committee member).
Subjects/Keywords: Lung nodule; CT; Active contour
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Chen, J. (2015). Improved Lung Nodules Detection with Active Contour Method and Machine Learning Based Classification. (Thesis). University of Illinois – Chicago. Retrieved from http://hdl.handle.net/10027/19404
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Chen, Jr-Shin. “Improved Lung Nodules Detection with Active Contour Method and Machine Learning Based Classification.” 2015. Thesis, University of Illinois – Chicago. Accessed February 26, 2021.
http://hdl.handle.net/10027/19404.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Chen, Jr-Shin. “Improved Lung Nodules Detection with Active Contour Method and Machine Learning Based Classification.” 2015. Web. 26 Feb 2021.
Vancouver:
Chen J. Improved Lung Nodules Detection with Active Contour Method and Machine Learning Based Classification. [Internet] [Thesis]. University of Illinois – Chicago; 2015. [cited 2021 Feb 26].
Available from: http://hdl.handle.net/10027/19404.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Chen J. Improved Lung Nodules Detection with Active Contour Method and Machine Learning Based Classification. [Thesis]. University of Illinois – Chicago; 2015. Available from: http://hdl.handle.net/10027/19404
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
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