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You searched for subject:(Long Residence Time). One record found.

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1. Vilums, Maris. Small changes for long term impact: optimization of structure kinetic properties : a case of CCR2 antagonists.

Degree: 2014, Leiden Academic Centre for Drug Research (LACDR), Faculty of Science, Leiden University

This thesis focuses on a new approach in drug discovery, the so-called drug-target residence time. Next to more traditional drug discovery efforts, which are based on structure-affinity relationships, this thesis describes the use of an additional parameter – the structure-kinetic relationships. Knowledge of this additional parameter at the early stages of drug discovery may help the pharmaceutical industry to generate better drug candidates. Additionally, it could save big expenses in the later stages of drug discovery by minimizing the attrition rate of drug candidates due to efficacy problems. In more detail, this thesis focuses on the synthesis of new high affinity and long residence time small molecule antagonists for the chemokine receptor CCR2 - a potential target for the treatment of various inflammatory diseases.

Subjects/Keywords: Structure-Kinetics Relationships; Long Residence Time; CCR2 antagonists; Indane; Inflammatory diseases; Structure-Kinetics Relationships; Long Residence Time; CCR2 antagonists; Indane; Inflammatory diseases

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Vilums, M. (2014). Small changes for long term impact: optimization of structure kinetic properties : a case of CCR2 antagonists. (Doctoral Dissertation). Leiden Academic Centre for Drug Research (LACDR), Faculty of Science, Leiden University. Retrieved from http://hdl.handle.net/1887/29811

Chicago Manual of Style (16th Edition):

Vilums, Maris. “Small changes for long term impact: optimization of structure kinetic properties : a case of CCR2 antagonists.” 2014. Doctoral Dissertation, Leiden Academic Centre for Drug Research (LACDR), Faculty of Science, Leiden University. Accessed August 10, 2020. http://hdl.handle.net/1887/29811.

MLA Handbook (7th Edition):

Vilums, Maris. “Small changes for long term impact: optimization of structure kinetic properties : a case of CCR2 antagonists.” 2014. Web. 10 Aug 2020.

Vancouver:

Vilums M. Small changes for long term impact: optimization of structure kinetic properties : a case of CCR2 antagonists. [Internet] [Doctoral dissertation]. Leiden Academic Centre for Drug Research (LACDR), Faculty of Science, Leiden University; 2014. [cited 2020 Aug 10]. Available from: http://hdl.handle.net/1887/29811.

Council of Science Editors:

Vilums M. Small changes for long term impact: optimization of structure kinetic properties : a case of CCR2 antagonists. [Doctoral Dissertation]. Leiden Academic Centre for Drug Research (LACDR), Faculty of Science, Leiden University; 2014. Available from: http://hdl.handle.net/1887/29811

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