subject:(Lipoproteins)

University of Otago

1. Hsu, Tien Chia. Lipoproteins and Hyperlipoproteinemia: Links to Gout .

Degree: 2012, University of Otago

► Gout and cardiovascular disease are both complex and multi-factorial with genetic predisposition and environmental triggers. Not only do both have high co-morbidity with other metabolic… (more)

▼ Gout and cardiovascular disease are both complex and multi-factorial with genetic predisposition and environmental triggers. Not only do both have high co-morbidity with other metabolic conditions, gout patients have high risk for cardiovascular events. Māori and Pacific populations have high risk for both gout and cardiovascular disease. The general aim of this study was to elucidate whether cardiovascular risk factors contribute to gout. New Zealand Caucasian and Māori/Pacific gout case and control sample sets were used. The serum lipid profile was investigated, including serum lipoprotein(a) (Lp(a)), measured with an enzyme-linked immunosorbant assay. Size exclusion chromatography was used on Māori and Pacific samples for detailed lipoprotein, apolipoprotein (apo) and lipid analyses. Increased prevalence for type III hyperlipoproteinemia (TIIIH; increased remnant lipoproteins which may result from the apo E isoform apo E2) and type IV hyperlipoproteinemia (TIVH; increased triglyceride (TG) due to increased very low density lipoprotein (VLDL) TG) was investigated. Single nucleotide polymorphisms (SNPs) in APOE determining isoforms APOE2 (rs7412) and APOE4 (rs429358) were genotyped. SNPs associated with an increased risk for cardiovascular disease were also genotyped, including rs3798220 and rs10455872 of LPA which also associate with Lp(a) levels, and rs1333049 of CDKN2BAS. Gout cases had increased total TG levels (p < 0.001) compared to gout controls in both Caucasian and Māori/Pacific sample sets. Māori and Pacific cases also had higher total and low density lipoprotein cholesterol, and lower high density lipoprotein cholesterol, than controls (p < 0.01). Chromatography analysis revealed a higher prevalence for TIVH in cases than controls (p < 0.001, odds ratio [95% confidence interval] = 7.7 [2.3 - 25.9]), due to an increased concentration of TG from an increased number of VLDL particles. No differences were found between VLDL cholesterol in cases and controls, indicating TIIIH prevalence was not increased in gout. Supporting this, APOE isoforms did not associate with gout. Lp(a) levels did not differ between Caucasian and Māori/Pacific subjects, nor by gout affliction. No associations were found between the two LPA SNPs and gout, or between the CDKN2BAS SNP and gout. The current study implicates that hypertriglyceridemia, inherent of the metabolic syndrome, is a linking factor between gout and cardiovascular disease. Future research exploring the relationship between the two diseases should be directed in this area, including testing genetic variants associated with hypertriglyceridemia for association with gout. Advisors/Committee Members: Merriman, Tony R (advisor).

Subjects/Keywords: gout; lipoproteins

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APA (6^th Edition):

Hsu, T. C. (2012). Lipoproteins and Hyperlipoproteinemia: Links to Gout . (Masters Thesis). University of Otago. Retrieved from http://hdl.handle.net/10523/2170

Chicago Manual of Style (16^th Edition):

Hsu, Tien Chia. “Lipoproteins and Hyperlipoproteinemia: Links to Gout .” 2012. Masters Thesis, University of Otago. Accessed March 03, 2021. http://hdl.handle.net/10523/2170.

MLA Handbook (7^th Edition):

Hsu, Tien Chia. “Lipoproteins and Hyperlipoproteinemia: Links to Gout .” 2012. Web. 03 Mar 2021.

Vancouver:

Hsu TC. Lipoproteins and Hyperlipoproteinemia: Links to Gout . [Internet] [Masters thesis]. University of Otago; 2012. [cited 2021 Mar 03]. Available from: http://hdl.handle.net/10523/2170.

Council of Science Editors:

Hsu TC. Lipoproteins and Hyperlipoproteinemia: Links to Gout . [Masters Thesis]. University of Otago; 2012. Available from: http://hdl.handle.net/10523/2170

Boston University

2. Baskys, Bronius. Nature of postheparin plasma clearing factor.

Degree: PhD, Immunochemistry, 1959, Boston University

URL: http://hdl.handle.net/2144/22327

Subjects/Keywords: Lipoproteins

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APA (6^th Edition):

Baskys, B. (1959). Nature of postheparin plasma clearing factor. (Doctoral Dissertation). Boston University. Retrieved from http://hdl.handle.net/2144/22327

Chicago Manual of Style (16^th Edition):

Baskys, Bronius. “Nature of postheparin plasma clearing factor.” 1959. Doctoral Dissertation, Boston University. Accessed March 03, 2021. http://hdl.handle.net/2144/22327.

MLA Handbook (7^th Edition):

Baskys, Bronius. “Nature of postheparin plasma clearing factor.” 1959. Web. 03 Mar 2021.

Vancouver:

Baskys B. Nature of postheparin plasma clearing factor. [Internet] [Doctoral dissertation]. Boston University; 1959. [cited 2021 Mar 03]. Available from: http://hdl.handle.net/2144/22327.

Council of Science Editors:

Baskys B. Nature of postheparin plasma clearing factor. [Doctoral Dissertation]. Boston University; 1959. Available from: http://hdl.handle.net/2144/22327

McGill University

3. Galis, Zorina S. Distribution of endogenous lipoproteins and sulfated proteoglycans in normal rabbit aorta and in atherosclerotic lesions induced by endothelial injury.

Degree: PhD, Department of Pathology, 1992, McGill University

URL: https://escholarship.mcgill.ca/downloads/wd375z824.pdf ; https://escholarship.mcgill.ca/concern/theses/gt54kq48n

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The effects of an endothelial injury, produced by balloon catheterization of the aorta in normocholesterolemic rabbits, were studied by immunocytochemical and biochemical methods. Apolipoprotein B… (more)

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The effects of an endothelial injury, produced by balloon catheterization of the aorta in normocholesterolemic rabbits, were studied by immunocytochemical and biochemical methods. Apolipoprotein B (apo B), as a marker for endogenous lipoproteins (LP), was detected by quantitative gold immunocytochemistry. In contrast to normal aortas, where apo B distribution was limited to the innermost regions, in previously injured aortas, apo B accumulated in advanced lesions developed under the regenerated endothelium, both in the extracellular space and inside foam cells, demonstrating the atherosclerotic nature of the lesions. In order to establish the putative role of chondroitin sulfate (CS) proteoglycans (PG), known for their great in vitro affinity for LP, the overall and ultrastructural distribution, as well as the biochemical properties of CS-PG molecules extracted from normal and injured aortas were examined. […]

Le projet concerne l'étude du rôle qu'une lésion de l'endothélium vasculaire peut jouer dans le développement de lésions athéromateuses. Les lésions sont obtenues expérimentalement chez le lapin suite à la cathéterisation de l'aorte. La distribution des lipoprotéines (LP) endogènes considérées athérogènes, détectées par un anticorps qui reconnait l'apolipoprotéine B (apo B) de lapin, a été étudiée par immunocytochimie ultrastructurelle quantitative à l'or colloïdal, dans des tissus provenant des aortes normales ou lésées. Dans les aortes normales, la distribution de l'apo Best restreinte a la couche endothéliale. Par contraste, dans les aortes lésées l'apo Best accumulée dans les lésions développées sous l'endothélium régénère, autant dans l'espace intercellulaire que dans les cellules, confirmant leur nature athéromateuse. Les caractéristiques biochimiques et morphologiques des proteoglycanes (PG) contenant des chaines de sulfate de chondroïtine, qui interagissent avec grande affinité avec LP in vitro, et on suppose par conséquent qu'ils soient aussi responsables de leur immobilisation dans les lésions athéromateuses, ont été analysées dans des tissus provenant des aortes normales ou lésées. […]

Advisors/Committee Members: Moore, Sean (Supervisor).

Subjects/Keywords: Lipoproteins

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APA (6^th Edition):

Galis, Z. S. (1992). Distribution of endogenous lipoproteins and sulfated proteoglycans in normal rabbit aorta and in atherosclerotic lesions induced by endothelial injury. (Doctoral Dissertation). McGill University. Retrieved from https://escholarship.mcgill.ca/downloads/wd375z824.pdf ; https://escholarship.mcgill.ca/concern/theses/gt54kq48n

Chicago Manual of Style (16^th Edition):

Galis, Zorina S. “Distribution of endogenous lipoproteins and sulfated proteoglycans in normal rabbit aorta and in atherosclerotic lesions induced by endothelial injury.” 1992. Doctoral Dissertation, McGill University. Accessed March 03, 2021. https://escholarship.mcgill.ca/downloads/wd375z824.pdf ; https://escholarship.mcgill.ca/concern/theses/gt54kq48n.

MLA Handbook (7^th Edition):

Galis, Zorina S. “Distribution of endogenous lipoproteins and sulfated proteoglycans in normal rabbit aorta and in atherosclerotic lesions induced by endothelial injury.” 1992. Web. 03 Mar 2021.

Vancouver:

Galis ZS. Distribution of endogenous lipoproteins and sulfated proteoglycans in normal rabbit aorta and in atherosclerotic lesions induced by endothelial injury. [Internet] [Doctoral dissertation]. McGill University; 1992. [cited 2021 Mar 03]. Available from: https://escholarship.mcgill.ca/downloads/wd375z824.pdf ; https://escholarship.mcgill.ca/concern/theses/gt54kq48n.

Council of Science Editors:

Galis ZS. Distribution of endogenous lipoproteins and sulfated proteoglycans in normal rabbit aorta and in atherosclerotic lesions induced by endothelial injury. [Doctoral Dissertation]. McGill University; 1992. Available from: https://escholarship.mcgill.ca/downloads/wd375z824.pdf ; https://escholarship.mcgill.ca/concern/theses/gt54kq48n

4. Suresh Kumar, N. Metabolism of very low density lipoproteins in primary cultures of rat hepatocytes;.

Degree: 2015, University of Kerala

URL: http://shodhganga.inflibnet.ac.in/handle/10603/54515

newline

Advisors/Committee Members: Kurup, P.A..

Subjects/Keywords: hepatocytes; lipoproteins

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APA (6^th Edition):

Suresh Kumar, N. (2015). Metabolism of very low density lipoproteins in primary cultures of rat hepatocytes;. (Thesis). University of Kerala. Retrieved from http://shodhganga.inflibnet.ac.in/handle/10603/54515

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Suresh Kumar, N. “Metabolism of very low density lipoproteins in primary cultures of rat hepatocytes;.” 2015. Thesis, University of Kerala. Accessed March 03, 2021. http://shodhganga.inflibnet.ac.in/handle/10603/54515.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Suresh Kumar, N. “Metabolism of very low density lipoproteins in primary cultures of rat hepatocytes;.” 2015. Web. 03 Mar 2021.

Vancouver:

Suresh Kumar N. Metabolism of very low density lipoproteins in primary cultures of rat hepatocytes;. [Internet] [Thesis]. University of Kerala; 2015. [cited 2021 Mar 03]. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/54515.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Suresh Kumar N. Metabolism of very low density lipoproteins in primary cultures of rat hepatocytes;. [Thesis]. University of Kerala; 2015. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/54515

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Toronto

5. Judd, Andrew. Investigating Surface Lipoprotein Translocation in Neisseria meningitidis.

Degree: 2014, University of Toronto

URL: http://hdl.handle.net/1807/71546

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Neisseria meningitidis infections are a major cause of bacterial meningitis cases around the world. During an infection, Neisseria meningitidis employs surface lipoproteins in nutrient acquisition… (more)

Subjects/Keywords: Surface Lipoproteins; Neisseria meningitidis; 0487

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APA (6^th Edition):

Judd, A. (2014). Investigating Surface Lipoprotein Translocation in Neisseria meningitidis. (Masters Thesis). University of Toronto. Retrieved from http://hdl.handle.net/1807/71546

Chicago Manual of Style (16^th Edition):

Judd, Andrew. “Investigating Surface Lipoprotein Translocation in Neisseria meningitidis.” 2014. Masters Thesis, University of Toronto. Accessed March 03, 2021. http://hdl.handle.net/1807/71546.

MLA Handbook (7^th Edition):

Judd, Andrew. “Investigating Surface Lipoprotein Translocation in Neisseria meningitidis.” 2014. Web. 03 Mar 2021.

Vancouver:

Judd A. Investigating Surface Lipoprotein Translocation in Neisseria meningitidis. [Internet] [Masters thesis]. University of Toronto; 2014. [cited 2021 Mar 03]. Available from: http://hdl.handle.net/1807/71546.

Council of Science Editors:

Judd A. Investigating Surface Lipoprotein Translocation in Neisseria meningitidis. [Masters Thesis]. University of Toronto; 2014. Available from: http://hdl.handle.net/1807/71546

University of Gothenburg / Göteborgs Universitet

6. Cramér, Kim, 1924-1992. Studies on human serum §-lipoproteins, including their protein moiety.

Degree: 1961, University of Gothenburg / Göteborgs Universitet

URL: http://hdl.handle.net/2077/17427

Subjects/Keywords: Lipoproteins; LDL

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APA (6^th Edition):

Cramér, Kim, 1. (1961). Studies on human serum §-lipoproteins, including their protein moiety. (Thesis). University of Gothenburg / Göteborgs Universitet. Retrieved from http://hdl.handle.net/2077/17427

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Cramér, Kim, 1924-1992. “Studies on human serum §-lipoproteins, including their protein moiety.” 1961. Thesis, University of Gothenburg / Göteborgs Universitet. Accessed March 03, 2021. http://hdl.handle.net/2077/17427.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Cramér, Kim, 1924-1992. “Studies on human serum §-lipoproteins, including their protein moiety.” 1961. Web. 03 Mar 2021.

Vancouver:

Cramér, Kim 1. Studies on human serum §-lipoproteins, including their protein moiety. [Internet] [Thesis]. University of Gothenburg / Göteborgs Universitet; 1961. [cited 2021 Mar 03]. Available from: http://hdl.handle.net/2077/17427.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Cramér, Kim 1. Studies on human serum §-lipoproteins, including their protein moiety. [Thesis]. University of Gothenburg / Göteborgs Universitet; 1961. Available from: http://hdl.handle.net/2077/17427

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Hong Kong

7. Lynn, Edward G. The role of lipoproteins in the development of glomerulosclerosis: y Edward G. Lynn.

Degree: 2000, University of Hong Kong

URL: http://hdl.handle.net/10722/32031

Subjects/Keywords: Lipoproteins.; Hypertriglyceridemia.

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APA (6^th Edition):

Lynn, E. G. (2000). The role of lipoproteins in the development of glomerulosclerosis: y Edward G. Lynn. (Thesis). University of Hong Kong. Retrieved from http://hdl.handle.net/10722/32031

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Lynn, Edward G. “The role of lipoproteins in the development of glomerulosclerosis: y Edward G. Lynn.” 2000. Thesis, University of Hong Kong. Accessed March 03, 2021. http://hdl.handle.net/10722/32031.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Lynn, Edward G. “The role of lipoproteins in the development of glomerulosclerosis: y Edward G. Lynn.” 2000. Web. 03 Mar 2021.

Vancouver:

Lynn EG. The role of lipoproteins in the development of glomerulosclerosis: y Edward G. Lynn. [Internet] [Thesis]. University of Hong Kong; 2000. [cited 2021 Mar 03]. Available from: http://hdl.handle.net/10722/32031.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Lynn EG. The role of lipoproteins in the development of glomerulosclerosis: y Edward G. Lynn. [Thesis]. University of Hong Kong; 2000. Available from: http://hdl.handle.net/10722/32031

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of British Columbia

8. Kocal, James Thomas. Characterization of the very low density lipoproteins and apoproteins of egg yolk granules.

Degree: PhD, Food Science, 1977, University of British Columbia

URL: http://hdl.handle.net/2429/21548

► The very low density lipoproteins (VLDL (MF)) from the granules of hen's egg yolk were isolated by a combination of preparative ultracentrifugation and agarose gel… (more)

▼ The very low density lipoproteins (VLDL (MF)) from the granules of hen's egg yolk were isolated by a combination of preparative ultracentrifugation and agarose gel filtration. Ultracentrifugal, electrophoretic and chromatographic analyses were performed to characterize and assess the purity of the VLDL (MF) and apoVLDL. The Beckman Prep UV Scanner accessory to the ultracentrifuge was used in conjunction with an on-line data acquisition system for the determination of flotation/sedimentation coefficients. The software that was developed to permit rapid data analysis using this system is described. An agarose disc gel electrophoretic system was developed which, in combination with the use of sudan black B prestained lipoproteins, allowed for rapid electrophoretic analysis of large VLDL (MF) particles. Flotation velocity analysis of VLDL (MF) indicated a heterogeneous preparation with two major floating boundaries (Sf 75 and 207S). Alkylation of VLDL (MF) with iodoacetamide to prevent aggregation due to oxidation of sulfhydryl groups decreased the flotation rates of the macromolecules to Sf 41 and 108S. It is possible that the VLDL (MF) particles exist in a partially aggregated state in fresh egg yolk. Concanavalin A affinity chromatography of VLDL (MF) produced a retained and an unretained fraction. The retained fraction contained twice as much total carbohydrate as the unfractionated VLDL (MF), while the unretained VLDL (MF) contained half as much carbohydrate. All fractions were glycoproteins containing hexose, hexosamine and sialic acid sugar residues. VLDL (MF) was partially delipidated with n-heptane which preferentially extracted the neutral lipids and preserved the solubility of the phospholipid-protein residues. Two fractions were isolated by gel filtration and characterized by analytical ultracentrifugation and by their phospholipid/protein ratios. VLDL (MF) was delipidated using sodium deoxycholate (NaDOC) and ethanol-ether procedures. Removal of lipids by both methods produced aggregated apoprotein, but the NaDOC apoprotein remained soluble. That obtained from ethanol-ether was precipitated, but could be solubilized in sodium dodecylsulfate (SDS) or urea. Tetramethylurea (TMU) was used to delipidate VLDL (MF) and dissociate the apoprotein. Electrophoretic analysis indicated the presence of three apoprotein subunits, one of which was an aggregate of the other two. SDS electrophoresis of the proteins extracted from the TMU gels demonstrated that each band was heterogeneous, containing many polypeptides. ApoVLDL was dissociated into 22 polypeptides (MW ranging from 9,600-136,000 daltons) in the presence of urea, SDS and 2-mercapto-ethanol (BME). Fourteen of these bands were glycoprotein in nature, staining positively with Schiff reagent. In the absence of BME, only 18 bands were resolved, most of which contained higher molecular weight aggregates not present in the reduced samples. The apoVLDL was fractionated on 6% agarose columns containing 8M urea or 2mM SDS. Two apoprotein fractions were…

Subjects/Keywords: Eggs; Lipoproteins

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APA (6^th Edition):

Kocal, J. T. (1977). Characterization of the very low density lipoproteins and apoproteins of egg yolk granules. (Doctoral Dissertation). University of British Columbia. Retrieved from http://hdl.handle.net/2429/21548

Chicago Manual of Style (16^th Edition):

Kocal, James Thomas. “Characterization of the very low density lipoproteins and apoproteins of egg yolk granules.” 1977. Doctoral Dissertation, University of British Columbia. Accessed March 03, 2021. http://hdl.handle.net/2429/21548.

MLA Handbook (7^th Edition):

Kocal, James Thomas. “Characterization of the very low density lipoproteins and apoproteins of egg yolk granules.” 1977. Web. 03 Mar 2021.

Vancouver:

Kocal JT. Characterization of the very low density lipoproteins and apoproteins of egg yolk granules. [Internet] [Doctoral dissertation]. University of British Columbia; 1977. [cited 2021 Mar 03]. Available from: http://hdl.handle.net/2429/21548.

Council of Science Editors:

Kocal JT. Characterization of the very low density lipoproteins and apoproteins of egg yolk granules. [Doctoral Dissertation]. University of British Columbia; 1977. Available from: http://hdl.handle.net/2429/21548

University of Sydney

9. Ng, Chun Yi. The role of macrophage phenotypes in atherosclerosis .

Degree: 2018, University of Sydney

URL: http://hdl.handle.net/2123/18697

► Background and aim: The rupture of atherosclerotic plaque is the key underlying cause of cardiovascular episodes including heart attack and stroke. A key contributor to… (more)

▼ Background and aim: The rupture of atherosclerotic plaque is the key underlying cause of cardiovascular episodes including heart attack and stroke. A key contributor to plaque instability is the macrophage. We found that while M1 macrophages are associated with plaque instability, M2 macrophages are not; rather they produce matrix molecules such as collagen that provide structural integrity to the cap. Modulating the balance of macrophage phenotypes in the plaques may hence be a treatment option. However, since some matrices, particularly the proteoglycans, can retain lipoproteins in the arterial wall, this study examined what proteoglycans M1 and M2 macrophages produce, and how is their degree of lipid binding. Method: Human monocyte-like THP-1 cells or the monocytes isolated from healthy donors were differentiated into M1 and M2 macrophages (and foam cells). The structure and low-density lipoprotein (LDL) binding ability of the proteoglycans were assessed. Results: M1 and M2 macrophages secreted a range of proteoglycans such as biglycan, perlecan and versican, with M2 macrophages producing more perlecan and versican. The glycosaminoglycan (GAG) chains decorating the core protein of these proteoglycans included chondroitin sulphate and heparan sulphate. The chondroitin sulphate produced by M1 macrophages were more sulphated than M2. Heparan sulphate from both cells included non-sulphated and sulphated disaccharides, with the latter being more abundant in the M1. The M1 proteoglycans bound more LDL than those of M2 and this was mediated by heparan sulphate. In contrast, LDL binding sites were found on the M2 proteoglycan core proteins, such as perlecan, with increased LDL binding evident upon cleavage of GAGs. M2 macrophages were co-localised with perlecan and lipid accumulation in plaques, suggesting that they may help in LDL retention via perlecan. When M1 and M2 macrophages transformed into foam cells, they produced less proteoglycans. However, the proteoglycans did not differ in the degree of LDL binding between the phenotypes. Conclusion: Both M1 and M2 macrophages produced proteoglycans that could bind LDL, but in different ways: the M1 macrophage-derived proteoglycans bound LDL via heparan sulphate, whereas those produced by M2 macrophages used core proteins to bind LDL. Therefore, M1 and M2 macrophages are likely to contribute to LDL retention during the development of atherosclerosis.

Subjects/Keywords: Atherosclerosis; macrophages; proteoglycans; lipoproteins; inflammation

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APA (6^th Edition):

Ng, C. Y. (2018). The role of macrophage phenotypes in atherosclerosis . (Thesis). University of Sydney. Retrieved from http://hdl.handle.net/2123/18697

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Ng, Chun Yi. “The role of macrophage phenotypes in atherosclerosis .” 2018. Thesis, University of Sydney. Accessed March 03, 2021. http://hdl.handle.net/2123/18697.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Ng, Chun Yi. “The role of macrophage phenotypes in atherosclerosis .” 2018. Web. 03 Mar 2021.

Vancouver:

Ng CY. The role of macrophage phenotypes in atherosclerosis . [Internet] [Thesis]. University of Sydney; 2018. [cited 2021 Mar 03]. Available from: http://hdl.handle.net/2123/18697.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Ng CY. The role of macrophage phenotypes in atherosclerosis . [Thesis]. University of Sydney; 2018. Available from: http://hdl.handle.net/2123/18697

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Michigan State University

10. Swope, Fred Carlton. Characteristics of membrane lipoprotein.

Degree: PhD, Department of Food Science, 1968, Michigan State University

URL: http://etd.lib.msu.edu/islandora/object/etd:36856

Subjects/Keywords: Lipoproteins; Milk

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APA (6^th Edition):

Swope, F. C. (1968). Characteristics of membrane lipoprotein. (Doctoral Dissertation). Michigan State University. Retrieved from http://etd.lib.msu.edu/islandora/object/etd:36856

Chicago Manual of Style (16^th Edition):

Swope, Fred Carlton. “Characteristics of membrane lipoprotein.” 1968. Doctoral Dissertation, Michigan State University. Accessed March 03, 2021. http://etd.lib.msu.edu/islandora/object/etd:36856.

MLA Handbook (7^th Edition):

Swope, Fred Carlton. “Characteristics of membrane lipoprotein.” 1968. Web. 03 Mar 2021.

Vancouver:

Swope FC. Characteristics of membrane lipoprotein. [Internet] [Doctoral dissertation]. Michigan State University; 1968. [cited 2021 Mar 03]. Available from: http://etd.lib.msu.edu/islandora/object/etd:36856.

Council of Science Editors:

Swope FC. Characteristics of membrane lipoprotein. [Doctoral Dissertation]. Michigan State University; 1968. Available from: http://etd.lib.msu.edu/islandora/object/etd:36856

Universidade Nova

11. Batuca, Joana Rita. Humoral response towards high density lipoprotein : a new mechanism for atherogenesis.

Degree: 2013, Universidade Nova

URL: http://www.rcaap.pt/detail.jsp?id=oai:run.unl.pt:10362/10860

► RESUMO:Aterosclerose é uma das principais causas de morbilidade e mortalidade no mundo ocidental. É responsável, direta ou indiretamente, pela maior percentagem de gastos com a… (more)

▼ RESUMO:Aterosclerose é uma das principais causas de morbilidade e mortalidade no mundo ocidental. É responsável, direta ou indiretamente, pela maior percentagem de gastos com a saúde na maioria dos países europeus. A “teoria lipídica” da aterosclerose, que se baseia na dislipidemia como causa primária para a doença vascular tem algumas implicações práticas importantes: permite a definição de linhas de orientação e protocolos simples e ainda estabelece alvos terapêuticos que podem ser atingidos na maior parte dos casos com a atual intervenção farmacológica. A associação da aterosclerose com o sistema imunológico (a “teoria imunológica”), forneceu por sua vez novas formas de explorar os mecanismos envolvidos e abriu novas perspetivas para um conhecimento mais completo da doença. No entanto, levanta dificuldades evidentes no que diz respeito às possibilidades terapêuticas. De todos os intervenientes no processo aterosclerótico (bioquímicos, imunológicos e anatómicos), as lipoproteínas de elevada densidade (HDL) são atualmente reconhecidas como um dos fatores mais importantes na aterogénese. Isto é baseado no reconhecimento das múltiplas propriedades anti-aterogénicas das HDL como por exemplo: a anti-oxidante, a anti-inflamatória e a antitrombótica, bem como o seu importante papel na melhoraria da função endotelial. Atualmente, é consensual que as funções anti-aterogénicas das HDL vão além do seu papel no transporte reverso do colesterol (RCT) e a importância das HDL no processo aterosclerótico baseia-se não apenas no seu papel protetor impedindo a formação da placa de ateroma, mas também na estabilização destas, prevenindo a sua ruptura e, consequentemente o evento trombótico. Como fundamentais no processo aterosclerótico estão reconhecidos dois principais conjuntos de eventos: um caracterizado por alterações no metabolismo das lipoproteínas que resultam em lipoproteínas pró-inflamatórias e pró-oxidantes que interagem com os componentes celulares da parede arterial e que conduzem à formação da placa de ateroma; o outro evento é a resposta imunológica desencadeada contra um novo conjunto de antigénios que por sua vez leva à produção de citoquinas pró-inflamatórias. Dada a complexidade da HDL e das suas múltiplas funções estas lipoproteínas tornaram-se um potencial alvo para a resposta auto-imune, e cujas consequências podem explicar algumas das associações identificados em estudos clínicos e epidemiológicos. Contudo esta interação entre o sistema imunológico e HDL nunca foi exaustivamente estudada. Portanto, pomos a hipótese de que em condições oxidativas e pró-inflamatórias, um aumento do antigénio (HDL) conduz a um consequente acréscimo na produção de anticorpos anti-HDL (aHDL) responsáveis pela alteração quantitativa e / ou qualitativa das HDL. O conceito de que estes anticorpos podem contribuir tanto para a evolução a longo prazo do processo aterosclerótico, como para o desencadeamento de eventos clínicos pode também explicar a heterogeneidade encontrada em cada doente e nos grandes estudos clínicos, no que…

Subjects/Keywords: Lipoproteins, HDL; Atherosclerosis; Lipoproteins - metabolism; Immune system - ummunology; Farmacologia

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Batuca, J. R. (2013). Humoral response towards high density lipoprotein : a new mechanism for atherogenesis. (Thesis). Universidade Nova. Retrieved from http://www.rcaap.pt/detail.jsp?id=oai:run.unl.pt:10362/10860

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Batuca, Joana Rita. “Humoral response towards high density lipoprotein : a new mechanism for atherogenesis.” 2013. Thesis, Universidade Nova. Accessed March 03, 2021. http://www.rcaap.pt/detail.jsp?id=oai:run.unl.pt:10362/10860.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Batuca, Joana Rita. “Humoral response towards high density lipoprotein : a new mechanism for atherogenesis.” 2013. Web. 03 Mar 2021.

Vancouver:

Batuca JR. Humoral response towards high density lipoprotein : a new mechanism for atherogenesis. [Internet] [Thesis]. Universidade Nova; 2013. [cited 2021 Mar 03]. Available from: http://www.rcaap.pt/detail.jsp?id=oai:run.unl.pt:10362/10860.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Batuca JR. Humoral response towards high density lipoprotein : a new mechanism for atherogenesis. [Thesis]. Universidade Nova; 2013. Available from: http://www.rcaap.pt/detail.jsp?id=oai:run.unl.pt:10362/10860

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Rochester Institute of Technology

12. Alberty, Deborah J. A Study of time and temperature variables affecting apolipoprotein B-100 on iodipamide ethyl ester particles.

Degree: School of Chemistry and Materials Science (COS), 1993, Rochester Institute of Technology

URL: https://scholarworks.rit.edu/theses/735

► The hypothesis tested in the epitope stability study is that apo B bound to a synthetic core of iodipamide ethyl ester (IDE) particles retain stability,… (more)

Subjects/Keywords: Chemistry; Blood lipoproteins

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APA (6^th Edition):

Alberty, D. J. (1993). A Study of time and temperature variables affecting apolipoprotein B-100 on iodipamide ethyl ester particles. (Thesis). Rochester Institute of Technology. Retrieved from https://scholarworks.rit.edu/theses/735

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Alberty, Deborah J. “A Study of time and temperature variables affecting apolipoprotein B-100 on iodipamide ethyl ester particles.” 1993. Thesis, Rochester Institute of Technology. Accessed March 03, 2021. https://scholarworks.rit.edu/theses/735.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Alberty, Deborah J. “A Study of time and temperature variables affecting apolipoprotein B-100 on iodipamide ethyl ester particles.” 1993. Web. 03 Mar 2021.

Vancouver:

Alberty DJ. A Study of time and temperature variables affecting apolipoprotein B-100 on iodipamide ethyl ester particles. [Internet] [Thesis]. Rochester Institute of Technology; 1993. [cited 2021 Mar 03]. Available from: https://scholarworks.rit.edu/theses/735.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Alberty DJ. A Study of time and temperature variables affecting apolipoprotein B-100 on iodipamide ethyl ester particles. [Thesis]. Rochester Institute of Technology; 1993. Available from: https://scholarworks.rit.edu/theses/735

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

13. Suresh Kumar N. Metabolism of Very Low Density Lipoproteins in Primary Cultures of Rat Hepatocytes;.

Degree: 2015, University of Kerala

URL: http://shodhganga.inflibnet.ac.in/handle/10603/45876

newline

Advisors/Committee Members: Kurup P A, Sudhakaran P R.

Subjects/Keywords: Hepatocytes; Lipoproteins; Metabolism

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APA (6^th Edition):

N, S. K. (2015). Metabolism of Very Low Density Lipoproteins in Primary Cultures of Rat Hepatocytes;. (Thesis). University of Kerala. Retrieved from http://shodhganga.inflibnet.ac.in/handle/10603/45876

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

N, Suresh Kumar. “Metabolism of Very Low Density Lipoproteins in Primary Cultures of Rat Hepatocytes;.” 2015. Thesis, University of Kerala. Accessed March 03, 2021. http://shodhganga.inflibnet.ac.in/handle/10603/45876.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

N, Suresh Kumar. “Metabolism of Very Low Density Lipoproteins in Primary Cultures of Rat Hepatocytes;.” 2015. Web. 03 Mar 2021.

Vancouver:

N SK. Metabolism of Very Low Density Lipoproteins in Primary Cultures of Rat Hepatocytes;. [Internet] [Thesis]. University of Kerala; 2015. [cited 2021 Mar 03]. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/45876.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

N SK. Metabolism of Very Low Density Lipoproteins in Primary Cultures of Rat Hepatocytes;. [Thesis]. University of Kerala; 2015. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/45876

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Texas A&M University

14. Dobson, Justin P. Effects of Docosahexaenoic Acid Supplementation on Lipids, Lipoproteins and Inflammatory Markers Following Heavy Physical Training in Division I Football Athletes.

Degree: PhD, Kinesiology, 2015, Texas A&M University

URL: http://hdl.handle.net/1969.1/161241

► Dietary docosahexaenoic acid (DHA) (22:6 n-3) has been linked to many health benefits in sedentary populations, positively altering lipid profiles and reducing inflammation. The prospective… (more)

▼ Dietary docosahexaenoic acid (DHA) (22:6 n-3) has been linked to many health benefits in sedentary populations, positively altering lipid profiles and reducing inflammation. The prospective impacts of DHA supplementation in an athletic population during intensive physical training are less clear. The first investigation describes inflammatory responses and the second describes lipid and lipoprotein responses during intensive physical training with DHA supplementation in football athletes. Sixty NCAA Division I football players (20 ± 1.5 years, 187.4 ± 6.1 cm, 105.7 ± 18.9 kg) were randomly assigned to 2 g•day^-1 DHA (n=28) or corn-oil placebo (n=32). Blood samples were collected at voluntary summer training (Summer), 30 days after Summer (Pre-camp), and 24 days after Pre-camp (Post-camp). Selected cytokines (multiplex assay), WBC, percent leukocytes, total cholesterol (TC), triglycerides (TG), LDL, HDL, IDL, and VLDL cholesterol (-C) and lipoprotein particles were analyzed. One sample t-tests (α=0.05) were used to assess differences in percent change of cytokine concentration, leukocyte concentration, lipoprotein concentration, particle numbers, and density at each time point; independent t-tests (α=0.05) were used for differences between groups at Summer. Eotaxin and monocyte chemoattractant protein-1 (MCP-1) elevations were significantly attenuated in the DHA group during preseason camp compared to Placebo (P < 0.05). Regulated on activation, normal T cell expressed and secreted (RANTES) was significantly elevated in both groups (P < 0.05); however, the percent change increase in the Placebo group was 2-fold that of the DHA group. White blood cell counts decreased at Post-camp (P < 0.05) in both groups. Pre-camp percent change TG was significantly (P < 0.05) increased only in the Placebo group. Post-camp percent change TG and HDL particle number in the DHA group was significantly (P < 0.05) reduced. LDL4 number significantly increased in the DHA group (Post-camp, P < 0.05), and the Placebo group decreased in LDL-C (Pre-camp, P < 0.05). Both groups had increased HDL2b-C and HDL2a-C at Pre-camp (P<0.05). Pre-camp LDL3-C and Post-camp LDL4-C increased in the DHA group (P<0.05). RLP-C increased in the Placebo group (Pre-camp, P<0.05). Pre-camp HDL density and Post-camp LDL density decreased in the Placebo group. The DHA group decreased HDL density during preseason, but LDL density remained constant. Summer IDL-C was significantly (P < 0.05) higher in the DHA group. Percent change VLDL number was significantly (P < 0.05) increased during preseason camp. There was no difference in lipoprotein-a and C-reactive protein between groups. TC, HDL-C, and RLP number did not change over time nor differ between groups. Pre-camp homocysteine increased, while Post-camp insulin significantly (P < 0.05) decreased in the DHA group. These investigations further our knowledge of a particular omega-3 fatty acid (DHA) as a potential lipid mediator to mitigate cardiovascular risk, as well as an inflammatory modulator for possible… Advisors/Committee Members: Crouse, Stephen F (advisor), Fluckey, James D (committee member), Riechman, Steven E (committee member), Smith, Stephen B (committee member).

Subjects/Keywords: Docosahexaenoic Acid; Inflammation, Lipids; Lipoproteins; Football

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Dobson, J. P. (2015). Effects of Docosahexaenoic Acid Supplementation on Lipids, Lipoproteins and Inflammatory Markers Following Heavy Physical Training in Division I Football Athletes. (Doctoral Dissertation). Texas A&M University. Retrieved from http://hdl.handle.net/1969.1/161241

Chicago Manual of Style (16^th Edition):

Dobson, Justin P. “Effects of Docosahexaenoic Acid Supplementation on Lipids, Lipoproteins and Inflammatory Markers Following Heavy Physical Training in Division I Football Athletes.” 2015. Doctoral Dissertation, Texas A&M University. Accessed March 03, 2021. http://hdl.handle.net/1969.1/161241.

MLA Handbook (7^th Edition):

Dobson, Justin P. “Effects of Docosahexaenoic Acid Supplementation on Lipids, Lipoproteins and Inflammatory Markers Following Heavy Physical Training in Division I Football Athletes.” 2015. Web. 03 Mar 2021.

Vancouver:

Dobson JP. Effects of Docosahexaenoic Acid Supplementation on Lipids, Lipoproteins and Inflammatory Markers Following Heavy Physical Training in Division I Football Athletes. [Internet] [Doctoral dissertation]. Texas A&M University; 2015. [cited 2021 Mar 03]. Available from: http://hdl.handle.net/1969.1/161241.

Council of Science Editors:

Dobson JP. Effects of Docosahexaenoic Acid Supplementation on Lipids, Lipoproteins and Inflammatory Markers Following Heavy Physical Training in Division I Football Athletes. [Doctoral Dissertation]. Texas A&M University; 2015. Available from: http://hdl.handle.net/1969.1/161241

Texas A&M University

15. Kieffer, Adam John. Lipoprotein Density Distributions Following Diet and Exercise Interventions.

Degree: PhD, Nutrition, 2016, Texas A&M University

URL: http://hdl.handle.net/1969.1/187338

► Atherosclerotic-related cardiovascular disease (ASCVD) claims the lives of over 600,000 Americans yearly. Current methodologies of assessment do not distinguish lipoprotein density distributions and instead measure… (more)

▼ Atherosclerotic-related cardiovascular disease (ASCVD) claims the lives of over 600,000 Americans yearly. Current methodologies of assessment do not distinguish lipoprotein density distributions and instead measure lipoprotein cholesterol, with lowdensity lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDLC) of primary clinical relevance. Furthermore, the distinction between the effects of diet and exercise interventions on lipoproteins is frequently indiscernible due to the effects of energy deficit induced by interventions. High- performance lipoprotein density profiling (HPLDP) provides a cost-effective way to rapidly assess the efficacy of diet or exercise interventions. The purpose of this study is to characterize density distribution of HDL subclasses in response to diet or exercise using HPLDP. Eighty-eight untrained subjects (74% male, average age of 54 years) were pooled from two lifestyle intervention studies that met the inclusion criteria. Following 12 weeks of diet or exercise interventions (750 kcal expenditure or 750 kcal deficit), subjects lost an average of 3.72 kg weight (-3.9%), lost 3.9 kg of body fat (-11.6%), increased lean mass 0.62 kg (+1.1%), and reduced body fat percentage by 3.41% (-9.1%). Average absolute VO2 max increased 0.16 liters O2/min (+7.1%) (p<0.05). Several lipoprotein density distributions were significantly different (p<0.05) between diet and exercise interventions (expressed as percent change from baseline): triglyceride-rich lipoproteins (TRL) (-17.14 vs 19.65), low-density lipoprotein subfraction 5 (LDL5) (-26.06 vs 8.14), high-density lipoprotein subfraction 3b (HDL3b) (-21.24 vs -0.71), and high-density lipoprotein subfraction 3c (HDL3c) (-17.88 vs 7.94). To elucidate the effects of cardiorespiratory fitness, subjects were further divided into categories of increased absolute VO2 max and decreased absolute VO2 max, with no changes between groups at baseline. Associations between absolute VO2 max percent change on TRL, LDL-5, HDL-3b, and HDL-3c percent change remained significant after controlling for age, gender, and fat mass percent change. A regression equation was constructed from significant correlations and effectively predicted HDL-3c changes using absolute VO2 max measurements. A significant linear relationship between improved absolute VO2 max and increased HDL-3c subfraction AUC exists; lipoprotein subfraction quantification may reveal positive effects of exercise overlooked using traditional clinical cholesterol assessment techniques. Advisors/Committee Members: Walzem, Rosemary L (advisor), Crouse, Stephen F (committee member), Riechman, Steven E (committee member), Smith, Stephen B (committee member).

Subjects/Keywords: lipoproteins; lipid; HDL; LDL; exercise; diet

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Kieffer, A. J. (2016). Lipoprotein Density Distributions Following Diet and Exercise Interventions. (Doctoral Dissertation). Texas A&M University. Retrieved from http://hdl.handle.net/1969.1/187338

Chicago Manual of Style (16^th Edition):

Kieffer, Adam John. “Lipoprotein Density Distributions Following Diet and Exercise Interventions.” 2016. Doctoral Dissertation, Texas A&M University. Accessed March 03, 2021. http://hdl.handle.net/1969.1/187338.

MLA Handbook (7^th Edition):

Kieffer, Adam John. “Lipoprotein Density Distributions Following Diet and Exercise Interventions.” 2016. Web. 03 Mar 2021.

Vancouver:

Kieffer AJ. Lipoprotein Density Distributions Following Diet and Exercise Interventions. [Internet] [Doctoral dissertation]. Texas A&M University; 2016. [cited 2021 Mar 03]. Available from: http://hdl.handle.net/1969.1/187338.

Council of Science Editors:

Kieffer AJ. Lipoprotein Density Distributions Following Diet and Exercise Interventions. [Doctoral Dissertation]. Texas A&M University; 2016. Available from: http://hdl.handle.net/1969.1/187338

University of Johannesburg

16. Schnetler, Rozanné. Lipidomic studies of meibomian expressions and immunological tear protein analysis in patients with keratoconus and dry eye disease.

Degree: 2014, University of Johannesburg

URL: http://hdl.handle.net/10210/11392

►

M.Sc. (Biochemistry)

Dry eye disease (DED) and keratoconus (KC) continue to affect the quality of life of many South Africans (and elsewhere) and in the… (more)

▼

M.Sc. (Biochemistry)

Dry eye disease (DED) and keratoconus (KC) continue to affect the quality of life of many South Africans (and elsewhere) and in the case of KC often leads to blindness. It is estimated that DED affects 14% to 33% of the population worldwide, while 1 in 2000 of the worlds population is affected by KC. However, details of the etiology of these diseases and their biochemical ‘fingerprint’ remain uncertain. In this study, emphasis was placed on the investigation of immunological proteins in the precorneal tear film of DED and KC subjects and meibomian lipids in these individuals. Tear fluid and meibum were collected from control, DED and KC volunteers. Control subjects were non-contact lens wearers and free from ocular diseases, whereas DED subjects were diagnosed by means of an ocular surface disease index (OSDI) questionnaire. DED subjects were divided into two groups: ‘moderate DED’ and ‘severe DED’ based on OSDI. KC subjects were diagnosed by the use of a slit-lamp biomicroscopy exam. Enzymelinked immunosorbent assays were performed to quantitate secretory immunoglobulin A (sIgA), tumour necrosis factor-alpha (TNF-á) and matrix metalloproteinase-1 (MMP-1) in the collected tear fluid. Meibum was analysed with proton nuclear magnetic resonance (1H-NMR) spectroscopy and Fourier transform infrared spectroscopy (FTIR). Multivariate data analyses (PCA) were used to extract interpretable information from the multidimensional data generated from the aforementioned techniques and used to build a broad picture of the general lipidomic differences between DED, KC and healthy subjects. Tear levels of sIgA and MMP-1 were significantly decreased in patients with KC compared to control. In contrast, the tears of severe DED subjects were characterised by higher levels of TNF-á and lower levels of sIgA. In subjects with moderate DED, TNF-á levels were significantly elevated. The results of this study re-emphasize that KC and DED individuals are associated with differential expression of specific tear proteins and support the view that the severity of DED is reflected in the levels of immunological proteins present in basal tears. Differences in the chemical composition of meibum from subjects with severe DED and KC compared to control were observed, more specifically in the aliphatic region of 1H-NMR spectra and C-C rocking region of FTIR spectra. The results therefore point towards the saturated components of fatty acids (and their chemical environments) as key targets for future investigations to elucidate compositional differences between DED, KC and healthy meibum.

Subjects/Keywords: Lipid membranes; Lipoproteins; Keratoconus; Dry eye syndromes

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APA (6^th Edition):

Schnetler, R. (2014). Lipidomic studies of meibomian expressions and immunological tear protein analysis in patients with keratoconus and dry eye disease. (Thesis). University of Johannesburg. Retrieved from http://hdl.handle.net/10210/11392

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Schnetler, Rozanné. “Lipidomic studies of meibomian expressions and immunological tear protein analysis in patients with keratoconus and dry eye disease.” 2014. Thesis, University of Johannesburg. Accessed March 03, 2021. http://hdl.handle.net/10210/11392.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Schnetler, Rozanné. “Lipidomic studies of meibomian expressions and immunological tear protein analysis in patients with keratoconus and dry eye disease.” 2014. Web. 03 Mar 2021.

Vancouver:

Schnetler R. Lipidomic studies of meibomian expressions and immunological tear protein analysis in patients with keratoconus and dry eye disease. [Internet] [Thesis]. University of Johannesburg; 2014. [cited 2021 Mar 03]. Available from: http://hdl.handle.net/10210/11392.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Schnetler R. Lipidomic studies of meibomian expressions and immunological tear protein analysis in patients with keratoconus and dry eye disease. [Thesis]. University of Johannesburg; 2014. Available from: http://hdl.handle.net/10210/11392

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Texas Southwestern Medical Center

17. Agarwala, Anandita. HDL Phospholipid and ABCA1-Mediated Cholesterol Efflux Are Reduced in Patients with Very High HDL-C Who Develop Early Coronary Artery Disease.

Degree: 2014, University of Texas Southwestern Medical Center

URL: http://hdl.handle.net/2152.5/3299

► BACKGROUND: Plasma levels of high-density lipoprotein cholesterol (HDL-C) are strongly inversely associated with coronary artery disease (CAD), and high HDL-C is generally associated with apparent… (more)

Subjects/Keywords: Cholesterol; Coronary Artery Disease; Lipoproteins, HDL

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APA (6^th Edition):

Agarwala, A. (2014). HDL Phospholipid and ABCA1-Mediated Cholesterol Efflux Are Reduced in Patients with Very High HDL-C Who Develop Early Coronary Artery Disease. (Thesis). University of Texas Southwestern Medical Center. Retrieved from http://hdl.handle.net/2152.5/3299

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Agarwala, Anandita. “HDL Phospholipid and ABCA1-Mediated Cholesterol Efflux Are Reduced in Patients with Very High HDL-C Who Develop Early Coronary Artery Disease.” 2014. Thesis, University of Texas Southwestern Medical Center. Accessed March 03, 2021. http://hdl.handle.net/2152.5/3299.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Agarwala, Anandita. “HDL Phospholipid and ABCA1-Mediated Cholesterol Efflux Are Reduced in Patients with Very High HDL-C Who Develop Early Coronary Artery Disease.” 2014. Web. 03 Mar 2021.

Vancouver:

Agarwala A. HDL Phospholipid and ABCA1-Mediated Cholesterol Efflux Are Reduced in Patients with Very High HDL-C Who Develop Early Coronary Artery Disease. [Internet] [Thesis]. University of Texas Southwestern Medical Center; 2014. [cited 2021 Mar 03]. Available from: http://hdl.handle.net/2152.5/3299.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Agarwala A. HDL Phospholipid and ABCA1-Mediated Cholesterol Efflux Are Reduced in Patients with Very High HDL-C Who Develop Early Coronary Artery Disease. [Thesis]. University of Texas Southwestern Medical Center; 2014. Available from: http://hdl.handle.net/2152.5/3299

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universidade Nova

18. Cascais, Maria João Coelho Melo. Lipoproteínas e inflamação na esclerose múltipla.

Degree: 2010, Universidade Nova

URL: http://www.rcaap.pt/detail.jsp?id=oai:run.unl.pt:10362/5039

► Preâmbulo Os processos inflamatórios induzem alterações marcadas do metabolismo das lipoproteínas plasmáticas e estas, por sua vez, regulam as reacções imunitárias. Dadas as muitas relações… (more)

▼ Preâmbulo Os processos inflamatórios induzem alterações marcadas do metabolismo das lipoproteínas plasmáticas e estas, por sua vez, regulam as reacções imunitárias. Dadas as muitas relações existentes entre imunidade inata e adquirida e o metabolismo das lipoproteínas, investigámos neste trabalho a sua possível relevância para a compreensão da Esclerose Múltipla (EM), uma doença neuroinflamatória e neurodegenrativa do Sistema Nervoso Central (SNC). Como será evidente ao longo da nossa exposição, consideramos também que ao tomarmos esta doença como modelo de investigação para estas interacções, poderemos também obter informação importante sobre as bases bioquímicas de mecanismos fisiopatológicos relevantes para muitas outras entidades patológicas. Dividiu-se esta dissertação nas seguintes partes e capítulos: PARTE I – INTRODUÇÃO Capítulo I. Introdução Neste capítulo faz-se uma breve definição da Esclerose Múltipla, dos seus mecanismos patogénicos, apresentação clínica, diagnóstico e tratamento. Capítulo 2. Inflamação e Esclerose Múltipla Apresentam-se alguns marcadores inflamatórios e as suas relações com EM detalhando aqueles com relevância para a discussão deste trabalho Capítulo 3. Lipoproteínas e EM Neste local são revistas as relações do metabolismo lipoproteico com os processos inflamatórios e a sua possível relevância para a EM Capítulo 4. Fundamentos e Objectivos do Trabalho Com base na revisão efectuada neste capítulo são apresentados os objectivos deste trabalho. PARTE II - MATERIAL E MÉTODOS Neste é caracterizada a população estudada, os parâmetros determinados, e metodologia laboratorial utilizada, e métodos estatísticos usados. PARTE III – RESULTADOS Os resultados obtidos e publicados são aqui apresentados PARTE IV – DISCUSSÃO Neste local efectuamos uma discussão geral dos resultados Parte V - SÍNTESE E CONCLUSÃO PARTE VI – BIBLIOGRAFIA ANEXOS Advisors/Committee Members: Sena, Armando José Nunes Harrington.

Subjects/Keywords: Lipoproteins - metabolism ; Multiple Sclerosis - diagnosis; Bioquímica

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APA (6^th Edition):

Cascais, M. J. C. M. (2010). Lipoproteínas e inflamação na esclerose múltipla. (Thesis). Universidade Nova. Retrieved from http://www.rcaap.pt/detail.jsp?id=oai:run.unl.pt:10362/5039

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Cascais, Maria João Coelho Melo. “Lipoproteínas e inflamação na esclerose múltipla.” 2010. Thesis, Universidade Nova. Accessed March 03, 2021. http://www.rcaap.pt/detail.jsp?id=oai:run.unl.pt:10362/5039.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Cascais, Maria João Coelho Melo. “Lipoproteínas e inflamação na esclerose múltipla.” 2010. Web. 03 Mar 2021.

Vancouver:

Cascais MJCM. Lipoproteínas e inflamação na esclerose múltipla. [Internet] [Thesis]. Universidade Nova; 2010. [cited 2021 Mar 03]. Available from: http://www.rcaap.pt/detail.jsp?id=oai:run.unl.pt:10362/5039.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Cascais MJCM. Lipoproteínas e inflamação na esclerose múltipla. [Thesis]. Universidade Nova; 2010. Available from: http://www.rcaap.pt/detail.jsp?id=oai:run.unl.pt:10362/5039

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Connecticut

19. zhou, mingyong. Development of Nanoscale Oral Delivery System for Nutrients Using Egg Yolk Lipoproteins.

Degree: MS, Nutritional Science, 2018, University of Connecticut

URL: https://opencommons.uconn.edu/gs_theses/1309

► Developing delivery vehicles using food-derived biomaterials is a commonly used approach to improve bioavailability of nutrients. Egg white proteins have been extensively studied as… (more)

Subjects/Keywords: egg yolk; lipoproteins; nanoscale; delivery system

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APA (6^th Edition):

zhou, m. (2018). Development of Nanoscale Oral Delivery System for Nutrients Using Egg Yolk Lipoproteins. (Masters Thesis). University of Connecticut. Retrieved from https://opencommons.uconn.edu/gs_theses/1309

Chicago Manual of Style (16^th Edition):

zhou, mingyong. “Development of Nanoscale Oral Delivery System for Nutrients Using Egg Yolk Lipoproteins.” 2018. Masters Thesis, University of Connecticut. Accessed March 03, 2021. https://opencommons.uconn.edu/gs_theses/1309.

MLA Handbook (7^th Edition):

zhou, mingyong. “Development of Nanoscale Oral Delivery System for Nutrients Using Egg Yolk Lipoproteins.” 2018. Web. 03 Mar 2021.

Vancouver:

zhou m. Development of Nanoscale Oral Delivery System for Nutrients Using Egg Yolk Lipoproteins. [Internet] [Masters thesis]. University of Connecticut; 2018. [cited 2021 Mar 03]. Available from: https://opencommons.uconn.edu/gs_theses/1309.

Council of Science Editors:

zhou m. Development of Nanoscale Oral Delivery System for Nutrients Using Egg Yolk Lipoproteins. [Masters Thesis]. University of Connecticut; 2018. Available from: https://opencommons.uconn.edu/gs_theses/1309

University of Adelaide

20. Kee, Patrick Han-Chee. The effects of plasma factors on the remodelling and metabolism of high density lipoproteins In vivo / by Patrick Han-Chee Kee.

Degree: 2004, University of Adelaide

URL: http://hdl.handle.net/2440/22061

Subjects/Keywords: High density lipoproteins.

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APA (6^th Edition):

Kee, P. H. (2004). The effects of plasma factors on the remodelling and metabolism of high density lipoproteins In vivo / by Patrick Han-Chee Kee. (Thesis). University of Adelaide. Retrieved from http://hdl.handle.net/2440/22061

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Kee, Patrick Han-Chee. “The effects of plasma factors on the remodelling and metabolism of high density lipoproteins In vivo / by Patrick Han-Chee Kee.” 2004. Thesis, University of Adelaide. Accessed March 03, 2021. http://hdl.handle.net/2440/22061.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Kee, Patrick Han-Chee. “The effects of plasma factors on the remodelling and metabolism of high density lipoproteins In vivo / by Patrick Han-Chee Kee.” 2004. Web. 03 Mar 2021.

Vancouver:

Kee PH. The effects of plasma factors on the remodelling and metabolism of high density lipoproteins In vivo / by Patrick Han-Chee Kee. [Internet] [Thesis]. University of Adelaide; 2004. [cited 2021 Mar 03]. Available from: http://hdl.handle.net/2440/22061.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Kee PH. The effects of plasma factors on the remodelling and metabolism of high density lipoproteins In vivo / by Patrick Han-Chee Kee. [Thesis]. University of Adelaide; 2004. Available from: http://hdl.handle.net/2440/22061

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Glasgow

21. Ardern, Hazel Alison. The regulation of hepatic lipoprotein metabolism in the St Thomas' Mixed Hyperlipidaemic rabbit.

Degree: PhD, 1999, University of Glasgow

URL: http://theses.gla.ac.uk/75494/ ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.323855

► The aim of this thesis was to characterise further the lipoprotein abnormalities present in the St Thomas' Mixed Hyperlipidaemic (SMHL) rabbit, assess the suitability of… (more)

▼ The aim of this thesis was to characterise further the lipoprotein abnormalities present in the St Thomas' Mixed Hyperlipidaemic (SMHL) rabbit, assess the suitability of this strain as an animal model for the human disorder familial combined hyperlipidaemia, and to investigate the genetic defect giving rise to the disorder. The SMHL rabbit colony was derived from the original St Thomas' Hospital rabbit colony, first described in 1987 as exhibiting elevated plasma cholesterol, plasma triglyceride or both. Indirect evidence for overproduction of VLDL and LDL apoB as the underlying metabolic defect was obtained. To investigate lipoprotein metabolism in these rabbits further, we made use of techniques already in place in our laboratory, developed a liver perfusion method and took advantage of new molecular biological techniques for mRNA quantitation. All studies were performed on rabbits fed a 0.08% cholesterol diet, which was found to exaggerate an already dyslipidaemic phenotype in the SMHL rabbits. Plasma cholesterol levels were found to be elevated in both young and mature male SMHL rabbits in comparison to NZW controls (p < 0.001, p = 0.04 respectively). Plasma triglyceride levels were elevated in young SMHL rabbits compared to young NZW (p < 0.001), but there was no difference between the strains in mature rabbits. These changes were found to be as a result of an increased mass of each of the lipoproteins studied: very low density lipoprotein (VLDL)1, VLDL2, intermediate density lipoprotein (IDL) and low density lipoprotein (LDL), (Sf 60 - 400, Sf 20 - 60, Sf 12 - 20 and Sf 0 - 12 respectively) but there was no alteration in lipoprotein composition or apolipoprotein content. The SMHL rabbits exhibited insulin resistance with exaggerated free fatty acid (FFA) and insulin responses to an oral glucose dose. Cholesteryl ester transfer protein (CETP) activities were increased 3 fold in the SMHL rabbits (p < 0.01), but there were no differences in hepatic lipase (HL) or lipoprotein lipase (LPL) activities. Investigation of the kinetics of lipoprotein metabolism using stable isotope labelling of apoB, yielded poor results due to the assays being at the limit of detection. There were no significant differences in production rates or catabolic rates of any of the lipoprotein species, however, trends towards increased VLDL1 and IDL production, and decreased IDL catabolism were seen. To investigate directly the output of apoB containing lipoproteins from the liver of the SMHL rabbits, we developed a method to perfuse the rabbit livers. This involved the perfusion of the organ for 3 hours with a recirculating, oxygenated Krebs Henseleit buffer at 37°C, and the isolation of lipoproteins from the perfusate at regular intervals throughout. We performed these studies in both young and mature NZW and SMHL rabbits. In the mature rabbits, total cholesterol output was increased in the SMHL rabbits, but not significantly so, and there was no difference in total triglyceride output. VLDLi, VLDL2, IDL and LDL were separated by density…

Subjects/Keywords: 572; SMHL; Lipoproteins

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APA (6^th Edition):

Ardern, H. A. (1999). The regulation of hepatic lipoprotein metabolism in the St Thomas' Mixed Hyperlipidaemic rabbit. (Doctoral Dissertation). University of Glasgow. Retrieved from http://theses.gla.ac.uk/75494/ ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.323855

Chicago Manual of Style (16^th Edition):

Ardern, Hazel Alison. “The regulation of hepatic lipoprotein metabolism in the St Thomas' Mixed Hyperlipidaemic rabbit.” 1999. Doctoral Dissertation, University of Glasgow. Accessed March 03, 2021. http://theses.gla.ac.uk/75494/ ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.323855.

MLA Handbook (7^th Edition):

Ardern, Hazel Alison. “The regulation of hepatic lipoprotein metabolism in the St Thomas' Mixed Hyperlipidaemic rabbit.” 1999. Web. 03 Mar 2021.

Vancouver:

Ardern HA. The regulation of hepatic lipoprotein metabolism in the St Thomas' Mixed Hyperlipidaemic rabbit. [Internet] [Doctoral dissertation]. University of Glasgow; 1999. [cited 2021 Mar 03]. Available from: http://theses.gla.ac.uk/75494/ ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.323855.

Council of Science Editors:

Ardern HA. The regulation of hepatic lipoprotein metabolism in the St Thomas' Mixed Hyperlipidaemic rabbit. [Doctoral Dissertation]. University of Glasgow; 1999. Available from: http://theses.gla.ac.uk/75494/ ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.323855

22. Kilsdonk, Liesbeth. High density lipoproteins and reverse cholesterol transport.

Degree: 1992, Erasmus University Medical Center

URL: http://hdl.handle.net/1765/40215

► textabstractThe e>:periments described in this thesis were performed in order to clarify the mechanism of efflux of cellular cholesterol, a key step in reverse cholesterol… (more)

▼ textabstractThe e>:periments described in this thesis were performed in order to clarify the mechanism of efflux of cellular cholesterol, a key step in reverse cholesterol transport. It is not known which factors influence the rate of transfer of cholesterol from cells to HDL. Rate limiting steps are important steps in the efflux process and may give more insight into the mechanism of the efflux of cellular cholesterol. Possible rate limiting steps are the cholesteryl ester hydrolysis and subsequent transport of cholesterol to the plasma membrane, the desorption of cholesterol from the membrane, the binding of HDL to the membrane or the composition of the HDL particles. The major pan of the experiments described in this thesis were performed with human endothelial cells (EAhy 926 cell line). These cells are hybrids of human umbilical vein endothelial cells with lung carcinoma cells (A549 line) and show many characteristics of differentiated endothelial cells, e.g., the expression of von Wille brand factor, tissue plasminogen activator, plasminogen activtor inhibitor-type 1, and the production of prostacyclin. In addition, the cells formed confluent monolayers with contact-inhibition of cell growth. For obvious reasons (see section 1.6) we choose to measure only net mass transfer of cholesterol from the cells and first developed a method to enrich the cells with cholesterol using cationized LDL (see chapter 2). Subsequently, we studied the efflux of cholesterol from loaded EAhy 926 cells by different plasma lipoproteins, and the effects of the plasma enzyme lecithin:cholesterol acyltransferase, as described in chapters 3 and 4. In chapter 5 the effect of HDL binding on HDL-mediated cholesterol efflux was studied using modifications of HDL with tetranitromethane and dimethyl suberimidate. The effect of cell membrane phospholipid composition on HDL binding and cholesterol efflux is described in chapter 6. All these experiments were carried out with ultracentrifugally isolated HDL or HDL,. HDL is a heterogeneous population of lipoprotein particles and HDL subfractions with distinct apolipoprotein compositions can be isolated from plasma with immune-affinity columns. The different apolipoprotein composition of these HDL subfractions are expected to be important for the interaction with possible plasma membrane HDL binding proteins and may therefore clarify the role of HDL binding in the efflux of cellular cholesterol. Chapter 7 and 8 contain a description of our investigations of the role of different immunopurified HDL subfractions in the efflux of cellular cholesterol from various cell types as well as in the uptake of HDL hy hepatocytes.

Subjects/Keywords: cholesterol; density; lipoproteins

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APA (6^th Edition):

Kilsdonk, L. (1992). High density lipoproteins and reverse cholesterol transport. (Doctoral Dissertation). Erasmus University Medical Center. Retrieved from http://hdl.handle.net/1765/40215

Chicago Manual of Style (16^th Edition):

Kilsdonk, Liesbeth. “High density lipoproteins and reverse cholesterol transport.” 1992. Doctoral Dissertation, Erasmus University Medical Center. Accessed March 03, 2021. http://hdl.handle.net/1765/40215.

MLA Handbook (7^th Edition):

Kilsdonk, Liesbeth. “High density lipoproteins and reverse cholesterol transport.” 1992. Web. 03 Mar 2021.

Vancouver:

Kilsdonk L. High density lipoproteins and reverse cholesterol transport. [Internet] [Doctoral dissertation]. Erasmus University Medical Center; 1992. [cited 2021 Mar 03]. Available from: http://hdl.handle.net/1765/40215.

Council of Science Editors:

Kilsdonk L. High density lipoproteins and reverse cholesterol transport. [Doctoral Dissertation]. Erasmus University Medical Center; 1992. Available from: http://hdl.handle.net/1765/40215

23. Oerlemans, M.C. Neutral lipolytic activities in rat liver.

Degree: 1979, Erasmus University Medical Center

URL: http://hdl.handle.net/1765/25790

Subjects/Keywords: lipoproteins; liver; rat

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APA (6^th Edition):

Oerlemans, M. C. (1979). Neutral lipolytic activities in rat liver. (Doctoral Dissertation). Erasmus University Medical Center. Retrieved from http://hdl.handle.net/1765/25790

Chicago Manual of Style (16^th Edition):

Oerlemans, M C. “Neutral lipolytic activities in rat liver.” 1979. Doctoral Dissertation, Erasmus University Medical Center. Accessed March 03, 2021. http://hdl.handle.net/1765/25790.

MLA Handbook (7^th Edition):

Oerlemans, M C. “Neutral lipolytic activities in rat liver.” 1979. Web. 03 Mar 2021.

Vancouver:

Oerlemans MC. Neutral lipolytic activities in rat liver. [Internet] [Doctoral dissertation]. Erasmus University Medical Center; 1979. [cited 2021 Mar 03]. Available from: http://hdl.handle.net/1765/25790.

Council of Science Editors:

Oerlemans MC. Neutral lipolytic activities in rat liver. [Doctoral Dissertation]. Erasmus University Medical Center; 1979. Available from: http://hdl.handle.net/1765/25790

Michigan State University

24. Briones, Esperanza R. Apolipoprotein metabolism in diabetes.

Degree: PhD, Department of Food Science and Human Nutrition, 1982, Michigan State University

URL: http://etd.lib.msu.edu/islandora/object/etd:44562

Subjects/Keywords: Diabetes; Lipoproteins – Metabolism

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APA (6^th Edition):

Briones, E. R. (1982). Apolipoprotein metabolism in diabetes. (Doctoral Dissertation). Michigan State University. Retrieved from http://etd.lib.msu.edu/islandora/object/etd:44562

Chicago Manual of Style (16^th Edition):

Briones, Esperanza R. “Apolipoprotein metabolism in diabetes.” 1982. Doctoral Dissertation, Michigan State University. Accessed March 03, 2021. http://etd.lib.msu.edu/islandora/object/etd:44562.

MLA Handbook (7^th Edition):

Briones, Esperanza R. “Apolipoprotein metabolism in diabetes.” 1982. Web. 03 Mar 2021.

Vancouver:

Briones ER. Apolipoprotein metabolism in diabetes. [Internet] [Doctoral dissertation]. Michigan State University; 1982. [cited 2021 Mar 03]. Available from: http://etd.lib.msu.edu/islandora/object/etd:44562.

Council of Science Editors:

Briones ER. Apolipoprotein metabolism in diabetes. [Doctoral Dissertation]. Michigan State University; 1982. Available from: http://etd.lib.msu.edu/islandora/object/etd:44562

Michigan State University

25. Thoma, Sharon Leah. Molecular and cellular characterization of non-specific lipid transfer proteins from spinach and Arabidopsis.

Degree: PhD, Department of Botany and Plant Pathology, 1992, Michigan State University

URL: http://etd.lib.msu.edu/islandora/object/etd:22576

Subjects/Keywords: Lipoproteins; Spinach; Arabidopsis

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APA (6^th Edition):

Thoma, S. L. (1992). Molecular and cellular characterization of non-specific lipid transfer proteins from spinach and Arabidopsis. (Doctoral Dissertation). Michigan State University. Retrieved from http://etd.lib.msu.edu/islandora/object/etd:22576

Chicago Manual of Style (16^th Edition):

Thoma, Sharon Leah. “Molecular and cellular characterization of non-specific lipid transfer proteins from spinach and Arabidopsis.” 1992. Doctoral Dissertation, Michigan State University. Accessed March 03, 2021. http://etd.lib.msu.edu/islandora/object/etd:22576.

MLA Handbook (7^th Edition):

Thoma, Sharon Leah. “Molecular and cellular characterization of non-specific lipid transfer proteins from spinach and Arabidopsis.” 1992. Web. 03 Mar 2021.

Vancouver:

Thoma SL. Molecular and cellular characterization of non-specific lipid transfer proteins from spinach and Arabidopsis. [Internet] [Doctoral dissertation]. Michigan State University; 1992. [cited 2021 Mar 03]. Available from: http://etd.lib.msu.edu/islandora/object/etd:22576.

Council of Science Editors:

Thoma SL. Molecular and cellular characterization of non-specific lipid transfer proteins from spinach and Arabidopsis. [Doctoral Dissertation]. Michigan State University; 1992. Available from: http://etd.lib.msu.edu/islandora/object/etd:22576

Michigan State University

26. Najt, Charles. The role of lipid droplet protein Perilipin 2 in lipid metabolism and inflammation.

Degree: 2016, Michigan State University

URL: http://etd.lib.msu.edu/islandora/object/etd:4303

►

Thesis Ph. D. Michigan State University. Biochemistry and Molecular Biology 2016

Perturbations in lipid droplet function have been implicated in promoting several diseases including type-2… (more)

▼

Thesis Ph. D. Michigan State University. Biochemistry and Molecular Biology 2016

Perturbations in lipid droplet function have been implicated in promoting several diseases including type-2 diabetes, atherosclerosis, and cardiovascular disease, yet few studies have focused on the role of lipid droplets and associated proteins in the regulation of inflammation. The most abundant lipid droplet protein in liver, Perilipin 2 (Plin2), has been shown to promote lipid accumulation, lipid droplet proliferation, and to augment inflammation in macrophages, yet the current approaches used to study Plin2 are generally descriptive and lack details on the mechanism of action. The objective of this study is to establish a mechanistic link between Plin2’s action on the lipid droplet and the onset of lipid-based inflammation by examining recombinant Plin2, overexpression-Plin2 cells, and Plin2 liver-specific knockout mice in the context of hepatic steatosis and inflammation. Using molecular modeling, fluorescence binding, circular dichroic, and FRET techniques, we demonstrated that Plin2 contains a lipid binding site that consists of a 4-helix bundle and unique / domain. We found that Plin2 residues 119−251 are critical for highest affinity lipid binding. Both stearic acid and cholesterol interact favorably with the Plin2 cleft formed by conserved residues in helix α6 and adjacent strands within the 4-helix bundle. Findings that Plin2 contains specific domains responsible for Plin2−lipid interactions and binding are significant because it suggests a mechanism by which Plin2 may retain pro-inflammatory lipids on the lipid droplet surface to promote inflammation. To support this hypothesis we treated cells with LPS to induce inflammation. Using a novel technique that traps eicosanoids at the site of synthesis, we found that Plin2-coated lipid droplets are the site of PGE2 production. These findings are consistent with our results showing that Plin2 actively recruits COX2 to the lipid droplet surface promoting eicosanoid biosynthesis. Taken together, our findings indicate that Plin2 may exert a significant role in COX-mediated inflammation through direct interactions on the lipid droplet surface. To establish Plin2’s inflammatory effect in vivo we challenged Plin2 liver-specific knockout mice and their respective wild type controls with a methionine-choline-deficient (MCD) diet to induce a NASH phenotype of increased hepatic steatosis, inflammation, and fibrosis. Results on liver weights, body weights, fat tissue mass, and histology in wild type and Plin2 null mice fed the MCD diet revealed signs of hepatic steatosis, fibrosis, and inflammation however; these effects were blunted in the Plin2 null mice. Levels of PC and VLDL were unchanged and hepatic steatosis was reduced by hepatic ablation of Plin2 due in part to an increase in remodeling of PE to PC via the enzyme phosphatidylethanolamine methyl transferase (PEMT). We also found that Plin2 ablation influences the hepatic miRNA-biome. Two of the miRNAs affected by Plin2 ablation…

Advisors/Committee Members: Atshaves, Barbara P, Kaguni, Laurie S, Hoffmann-Benning, Susanne, Hoogstraten, Charles G, Yang, Chengfeng.

Subjects/Keywords: Lipoproteins; Lipids – Metabolism; Inflammation – Mediators; Biochemistry

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APA (6^th Edition):

Najt, C. (2016). The role of lipid droplet protein Perilipin 2 in lipid metabolism and inflammation. (Thesis). Michigan State University. Retrieved from http://etd.lib.msu.edu/islandora/object/etd:4303

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Najt, Charles. “The role of lipid droplet protein Perilipin 2 in lipid metabolism and inflammation.” 2016. Thesis, Michigan State University. Accessed March 03, 2021. http://etd.lib.msu.edu/islandora/object/etd:4303.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Najt, Charles. “The role of lipid droplet protein Perilipin 2 in lipid metabolism and inflammation.” 2016. Web. 03 Mar 2021.

Vancouver:

Najt C. The role of lipid droplet protein Perilipin 2 in lipid metabolism and inflammation. [Internet] [Thesis]. Michigan State University; 2016. [cited 2021 Mar 03]. Available from: http://etd.lib.msu.edu/islandora/object/etd:4303.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Najt C. The role of lipid droplet protein Perilipin 2 in lipid metabolism and inflammation. [Thesis]. Michigan State University; 2016. Available from: http://etd.lib.msu.edu/islandora/object/etd:4303

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Arizona

27. Whitfill, Craig Everett, 1944-. Partial separation and characterization of human serum low density lipoprotein .

Degree: 1969, University of Arizona

URL: http://hdl.handle.net/10150/347687

Subjects/Keywords: Lipoproteins.; Lipids – Analysis.

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APA (6^th Edition):

Whitfill, Craig Everett, 1. (1969). Partial separation and characterization of human serum low density lipoprotein . (Masters Thesis). University of Arizona. Retrieved from http://hdl.handle.net/10150/347687

Chicago Manual of Style (16^th Edition):

Whitfill, Craig Everett, 1944-. “Partial separation and characterization of human serum low density lipoprotein .” 1969. Masters Thesis, University of Arizona. Accessed March 03, 2021. http://hdl.handle.net/10150/347687.

MLA Handbook (7^th Edition):

Whitfill, Craig Everett, 1944-. “Partial separation and characterization of human serum low density lipoprotein .” 1969. Web. 03 Mar 2021.

Vancouver:

Whitfill, Craig Everett 1. Partial separation and characterization of human serum low density lipoprotein . [Internet] [Masters thesis]. University of Arizona; 1969. [cited 2021 Mar 03]. Available from: http://hdl.handle.net/10150/347687.

Council of Science Editors:

Whitfill, Craig Everett 1. Partial separation and characterization of human serum low density lipoprotein . [Masters Thesis]. University of Arizona; 1969. Available from: http://hdl.handle.net/10150/347687

University of Hong Kong

28. 朱瑞中. Regulation of lipoprotein uptake in mammalian cells.

Degree: 2000, University of Hong Kong

URL: http://hdl.handle.net/10722/28354

Subjects/Keywords: Homocysteine; Lipoproteins; Endothelium

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APA (6^th Edition):

朱瑞中. (2000). Regulation of lipoprotein uptake in mammalian cells. (Thesis). University of Hong Kong. Retrieved from http://hdl.handle.net/10722/28354

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

朱瑞中. “Regulation of lipoprotein uptake in mammalian cells.” 2000. Thesis, University of Hong Kong. Accessed March 03, 2021. http://hdl.handle.net/10722/28354.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

朱瑞中. “Regulation of lipoprotein uptake in mammalian cells.” 2000. Web. 03 Mar 2021.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete

Vancouver:

朱瑞中. Regulation of lipoprotein uptake in mammalian cells. [Internet] [Thesis]. University of Hong Kong; 2000. [cited 2021 Mar 03]. Available from: http://hdl.handle.net/10722/28354.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

朱瑞中. Regulation of lipoprotein uptake in mammalian cells. [Thesis]. University of Hong Kong; 2000. Available from: http://hdl.handle.net/10722/28354

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation

Delft University of Technology

29. Pieters, M.N. The interaction of high-density lipoproteins with the liver : Role in reverse cholesterol transport.

Degree: 1993, Delft University of Technology

URL: http://resolver.tudelft.nl/uuid:d1aeba30-b648-4746-a097-f4a243fcc2c9 ; urn:NBN:nl:ui:24-uuid:d1aeba30-b648-4746-a097-f4a243fcc2c9 ; urn:isbn:9090064028 ; urn:NBN:nl:ui:24-uuid:d1aeba30-b648-4746-a097-f4a243fcc2c9 ; http://resolver.tudelft.nl/uuid:d1aeba30-b648-4746-a097-f4a243fcc2c9

Subjects/Keywords: Biology; Liver; Lipoproteins

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APA (6^th Edition):

Pieters, M. N. (1993). The interaction of high-density lipoproteins with the liver : Role in reverse cholesterol transport. (Doctoral Dissertation). Delft University of Technology. Retrieved from http://resolver.tudelft.nl/uuid:d1aeba30-b648-4746-a097-f4a243fcc2c9 ; urn:NBN:nl:ui:24-uuid:d1aeba30-b648-4746-a097-f4a243fcc2c9 ; urn:isbn:9090064028 ; urn:NBN:nl:ui:24-uuid:d1aeba30-b648-4746-a097-f4a243fcc2c9 ; http://resolver.tudelft.nl/uuid:d1aeba30-b648-4746-a097-f4a243fcc2c9

Chicago Manual of Style (16^th Edition):

Pieters, M N. “The interaction of high-density lipoproteins with the liver : Role in reverse cholesterol transport.” 1993. Doctoral Dissertation, Delft University of Technology. Accessed March 03, 2021. http://resolver.tudelft.nl/uuid:d1aeba30-b648-4746-a097-f4a243fcc2c9 ; urn:NBN:nl:ui:24-uuid:d1aeba30-b648-4746-a097-f4a243fcc2c9 ; urn:isbn:9090064028 ; urn:NBN:nl:ui:24-uuid:d1aeba30-b648-4746-a097-f4a243fcc2c9 ; http://resolver.tudelft.nl/uuid:d1aeba30-b648-4746-a097-f4a243fcc2c9.

MLA Handbook (7^th Edition):

Pieters, M N. “The interaction of high-density lipoproteins with the liver : Role in reverse cholesterol transport.” 1993. Web. 03 Mar 2021.

Vancouver:

Pieters MN. The interaction of high-density lipoproteins with the liver : Role in reverse cholesterol transport. [Internet] [Doctoral dissertation]. Delft University of Technology; 1993. [cited 2021 Mar 03]. Available from: http://resolver.tudelft.nl/uuid:d1aeba30-b648-4746-a097-f4a243fcc2c9 ; urn:NBN:nl:ui:24-uuid:d1aeba30-b648-4746-a097-f4a243fcc2c9 ; urn:isbn:9090064028 ; urn:NBN:nl:ui:24-uuid:d1aeba30-b648-4746-a097-f4a243fcc2c9 ; http://resolver.tudelft.nl/uuid:d1aeba30-b648-4746-a097-f4a243fcc2c9.

Council of Science Editors:

Pieters MN. The interaction of high-density lipoproteins with the liver : Role in reverse cholesterol transport. [Doctoral Dissertation]. Delft University of Technology; 1993. Available from: http://resolver.tudelft.nl/uuid:d1aeba30-b648-4746-a097-f4a243fcc2c9 ; urn:NBN:nl:ui:24-uuid:d1aeba30-b648-4746-a097-f4a243fcc2c9 ; urn:isbn:9090064028 ; urn:NBN:nl:ui:24-uuid:d1aeba30-b648-4746-a097-f4a243fcc2c9 ; http://resolver.tudelft.nl/uuid:d1aeba30-b648-4746-a097-f4a243fcc2c9

McGill University

30. Spain, Michael J. The effects of serum low density lipoproteins on skin fibroblasts and aortic smooth muscle cells in culture.

Degree: PhD, Department of Experimental Medicine, 1979, McGill University

URL: https://escholarship.mcgill.ca/downloads/ff365762s.pdf ; https://escholarship.mcgill.ca/concern/theses/xw42nb24b

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Des facteurs majeurs dans l'athérogènes semblent être les lipoprotéines plasmatiques.L'effet des lipoprotéines sériques à faible densité (LDL) d'origine humaine fut étudiés dans des cultures de… (more)

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Des facteurs majeurs dans l'athérogènes semblent être les lipoprotéines plasmatiques.L'effet des lipoprotéines sériques à faible densité (LDL) d'origine humaine fut étudiés dans des cultures de fibroblastesde peau humaines maintenues dans un milieu additioné de sérum humain pauvre en plaquettes et dépourvu de lipoprotéines (PPLFS). Les effets produits par les LDL furent une augmentation de la vitesse de réplication cellulaire, une augmentation du contenu cellulaire en cholestérol et en protéines, une augmentation de la grosseur des cellules et un accroissement de l'accumulation des glycosaminoglycanes (GAG) dans le milieu de culture. L'effet des LDL sur la prolifération cellulaire fut aboli par l'ultrafiltration du PPLFS. Les augmentations de cholestérol et de protéine étaient proportionnelles ainsi que les augmentations en protéines et en grosseur cellulaire. Nous avons déduit de ces résultats que les augmentations en cholestérol et en protéines étaient de type structural plutôt que d'emmagasinement. Le contenu protéique élevé de cellules est dû à une diminution de leur vitesse de dégradation. [...]

Plasma lipoproteins appear to be major factors in atherogenesis. The effects of human serum low density lipoproteins (LDL) were studied in cultures of human skin fibroblasts maintained in medium supplemented with human platelet-poor, lipoprotein-free serum· (PPLFS). LDL increased the proliferation, the size, and the contents of cholesterol and protein of cells, and led to an enhanced accumulation of glycosaminoglycans (GAG) in the medium. The LDL effect on proliferation was abolished by ultrafiltration of PPLFS. Increases in cholesterol and protein were proportional as were' increases in protein and cell size. It was inferred that cholesterol and protein accumulated in structural rather than storage forms. Elevations in cellular protein content were caused by a decreased rate of protein degradation. No LDL effect on proliferation was observed in cultures of porcine aortic smooth muscle cells in PPLFS medium. No abnormalities of diabetic cell responses to LDL or of the compositions of serum lipoproteins from diabetics were found.

Advisors/Committee Members: Dr. N. Kalant.

Subjects/Keywords: Lipoproteins.; Cells, Cultured.

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APA (6^th Edition):

Spain, M. J. (1979). The effects of serum low density lipoproteins on skin fibroblasts and aortic smooth muscle cells in culture. (Doctoral Dissertation). McGill University. Retrieved from https://escholarship.mcgill.ca/downloads/ff365762s.pdf ; https://escholarship.mcgill.ca/concern/theses/xw42nb24b

Chicago Manual of Style (16^th Edition):

Spain, Michael J. “The effects of serum low density lipoproteins on skin fibroblasts and aortic smooth muscle cells in culture.” 1979. Doctoral Dissertation, McGill University. Accessed March 03, 2021. https://escholarship.mcgill.ca/downloads/ff365762s.pdf ; https://escholarship.mcgill.ca/concern/theses/xw42nb24b.

MLA Handbook (7^th Edition):

Spain, Michael J. “The effects of serum low density lipoproteins on skin fibroblasts and aortic smooth muscle cells in culture.” 1979. Web. 03 Mar 2021.

Vancouver:

Spain MJ. The effects of serum low density lipoproteins on skin fibroblasts and aortic smooth muscle cells in culture. [Internet] [Doctoral dissertation]. McGill University; 1979. [cited 2021 Mar 03]. Available from: https://escholarship.mcgill.ca/downloads/ff365762s.pdf ; https://escholarship.mcgill.ca/concern/theses/xw42nb24b.

Council of Science Editors:

Spain MJ. The effects of serum low density lipoproteins on skin fibroblasts and aortic smooth muscle cells in culture. [Doctoral Dissertation]. McGill University; 1979. Available from: https://escholarship.mcgill.ca/downloads/ff365762s.pdf ; https://escholarship.mcgill.ca/concern/theses/xw42nb24b

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