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1.
山下, 嘉郎.
Multicolor Flow Cytometric Analyses of CD4+ T Cell Responses to Mycobacterium tuberculosis-Related Latent Antigens : 結核潜伏期関連抗原に対するCD4陽性T細胞反応のマルチカラーフローサイトメトリーを用いた解析.
Degree: 博士(医学), 2013, Nagasaki University / 長崎大学
URL: http://hdl.handle.net/10069/35238
► Although IFN-γ release assays (IγRAs) provide increased specificity over tuberculin skin tests, the early and sensitive detection of reactivation of latently infected Mycobacterium tuberculosis is…
(more)
▼ Although IFN-γ release assays (IγRAs) provide increased specificity over tuberculin skin tests, the early and sensitive detection of reactivation of latently infected Mycobacterium tuberculosis is required to control tuberculosis (TB). Recently, a multicolor flow cytometry has been developed to study CD4+ T cell cytokine responses (IFN-γ/IL-2/TNF-a) to purified protein derivatives (PPD) and M. tuberculosis-specific antigens (ESAT-6/CFP-10) and provided useful information regarding anti-TB immunity. However, the diagnostic relevancy remains uncertain. Here, we analyzed three additional CD4+ T cell cytokine responses (IL-10/IL-13/IL-17) to latent mycobacterial antigens (a-crystallin, methylated heparin-binding hemagglutinin [HBHA], and mycobacterial DNA-binding protein 1 [MDP-1]) as well as PPD and ESAT-6/CFP-10 in 12 IGRA+ TB cases and 8 healthy controls. No significant difference in IFN-γ response was observed between TB cases and controls, which was likely due to the high variation among the individuals. However, we found a significant increase over healthy controls in (i) the IL-2 response to HBHA in recovery stage TB cases, (ii) the number of M. tuberculosisspecific polyfunctional CD4+ T cells in on-treatment and recovery stage cases, and (iii) the IL-17 response to HBHA and MDP-1 in on-treatment and recovery stage cases. These results suggest that a combination of these T cell cytokine parameters could aid in accurate diagnosis of latent TB infection.
Subjects/Keywords: tuberculosis; T cell cytokine response; latent infection
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APA (6th Edition):
山下, . (2013). Multicolor Flow Cytometric Analyses of CD4+ T Cell Responses to Mycobacterium tuberculosis-Related Latent Antigens : 結核潜伏期関連抗原に対するCD4陽性T細胞反応のマルチカラーフローサイトメトリーを用いた解析. (Thesis). Nagasaki University / 長崎大学. Retrieved from http://hdl.handle.net/10069/35238
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
山下, 嘉郎. “Multicolor Flow Cytometric Analyses of CD4+ T Cell Responses to Mycobacterium tuberculosis-Related Latent Antigens : 結核潜伏期関連抗原に対するCD4陽性T細胞反応のマルチカラーフローサイトメトリーを用いた解析.” 2013. Thesis, Nagasaki University / 長崎大学. Accessed January 22, 2021.
http://hdl.handle.net/10069/35238.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
山下, 嘉郎. “Multicolor Flow Cytometric Analyses of CD4+ T Cell Responses to Mycobacterium tuberculosis-Related Latent Antigens : 結核潜伏期関連抗原に対するCD4陽性T細胞反応のマルチカラーフローサイトメトリーを用いた解析.” 2013. Web. 22 Jan 2021.
Vancouver:
山下 . Multicolor Flow Cytometric Analyses of CD4+ T Cell Responses to Mycobacterium tuberculosis-Related Latent Antigens : 結核潜伏期関連抗原に対するCD4陽性T細胞反応のマルチカラーフローサイトメトリーを用いた解析. [Internet] [Thesis]. Nagasaki University / 長崎大学; 2013. [cited 2021 Jan 22].
Available from: http://hdl.handle.net/10069/35238.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
山下 . Multicolor Flow Cytometric Analyses of CD4+ T Cell Responses to Mycobacterium tuberculosis-Related Latent Antigens : 結核潜伏期関連抗原に対するCD4陽性T細胞反応のマルチカラーフローサイトメトリーを用いた解析. [Thesis]. Nagasaki University / 長崎大学; 2013. Available from: http://hdl.handle.net/10069/35238
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Addis Ababa University
2.
Tewodros, Tariku.
Innate Immunity to Tuberculosis in advanced HIV/AIDS patients
.
Degree: 2013, Addis Ababa University
URL: http://etd.aau.edu.et/dspace/handle/123456789/430
► Several factors influence resistance or susceptibility to tuberculosis (TB) in an immunocompromised host. Animal studies have shown the contributions innate immunity on host resistance to…
(more)
▼ Several factors influence resistance or susceptibility to tuberculosis (TB) in an immunocompromised host. Animal studies have shown the contributions innate immunity on host resistance to TB disease in the absence of intact adaptive immunity (Feng et al., 2006). We extended these observations to humans to assess the innate mechanisms that prevent the development of active TB in advanced AIDS patients with compromised CD4+ T cell functions. In a cross-sectional study, we determined macrophage mediated killing of Mycobacterium tuberculosis (M. tuberculosis ) and measured the production of inducible nitric oxide synthase (iNOS), tumor necrosis factor-alpha (TNF-α) and interleukin-10 (IL-10). We also assessed intracellular expression of IFN-γ in NK, γ/δ (CD3+ γ/δ+) and adaptive (CD3+ γ/δ -) cells in response to purified protein derivative (PPD) and live M. tuberculosis . We found better innate functions in macrophage killing and IFN-γ production in AIDS patients with
latent TB
infection compared to AIDS patients who progress to TB disease, but the differences did not reach statistical significance. The study suggests that variation in susceptibility to TB in AIDS patients could be due to innate immunity but our observation warrants confirmation in larger prospective study to consolidate this hypothesis. A better understanding of these factors might help in making preventive therapies to HIV patients that are most likely to develop TB.
Advisors/Committee Members: Dr. Rawleigh Howe (advisor).
Subjects/Keywords: Innate immunity;
Susceptibility;
Resistance;
Latent TB infection
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APA (6th Edition):
Tewodros, T. (2013). Innate Immunity to Tuberculosis in advanced HIV/AIDS patients
. (Thesis). Addis Ababa University. Retrieved from http://etd.aau.edu.et/dspace/handle/123456789/430
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Tewodros, Tariku. “Innate Immunity to Tuberculosis in advanced HIV/AIDS patients
.” 2013. Thesis, Addis Ababa University. Accessed January 22, 2021.
http://etd.aau.edu.et/dspace/handle/123456789/430.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Tewodros, Tariku. “Innate Immunity to Tuberculosis in advanced HIV/AIDS patients
.” 2013. Web. 22 Jan 2021.
Vancouver:
Tewodros T. Innate Immunity to Tuberculosis in advanced HIV/AIDS patients
. [Internet] [Thesis]. Addis Ababa University; 2013. [cited 2021 Jan 22].
Available from: http://etd.aau.edu.et/dspace/handle/123456789/430.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Tewodros T. Innate Immunity to Tuberculosis in advanced HIV/AIDS patients
. [Thesis]. Addis Ababa University; 2013. Available from: http://etd.aau.edu.et/dspace/handle/123456789/430
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Melbourne
3.
Bhuiyan, Md Abdullahil Baki.
Biology and host-pathogen interaction of Stagonosporopsis tanaceti, the cause of ray blight in pyrethrum.
Degree: 2017, University of Melbourne
URL: http://hdl.handle.net/11343/192512
► Ray blight (Stagonosporopsis tanaceti) is a major biotic constraint for pyrethrum production in Australia. The biology and host-pathogen interaction of S. tanaceti in seed, seedlings…
(more)
▼ Ray blight (Stagonosporopsis tanaceti) is a major biotic constraint for pyrethrum production in Australia. The biology and host-pathogen interaction of S. tanaceti in seed, seedlings and mature pyrethrum plants were studied in glasshouse experiments. Molecular detection and quantification of infection within pyrethrum tissues were determined using TaqMan PCR.
Direct penetration into the epidermal cells of leaves resulted in the development of brown to black necrotic lesions. Hyphae of S. tanaceti then colonised the cortical tissues intra- and intercellularly resulting in degradation of tissues and deposition of extra-cellular material in necrotic cells. Pycnidia formed within 12 days after infection in the epidermis and hypodermis of pyrethrum leaves. Quadruple staining technique was more suitable than single or dual staining for visualising fungal hyphae within the tissue because the combination of four stains enabled the hyphae to stain blue-green in contrast to the cell tissues.
Stagonosporopsis tanaceti infected only the seed coat and not the embryo with infected seed being symptomless and not deformed or discoloured. After germination, S. tanaceti infected the embryonic tissues in the seed coat and depending on the level of infection of these tissues, resulted in pre-emergence and post-emergence damping off. Degradation of whole embryonic tissues by S. tanaceti resulted in pre-emergence death while disintegration of hypocotyl/crown tissues resulted in post-emergence death. Some of the infected embryos developed into seedlings with S. tanaceti being present in the hypocotyl/ crown tissues without these tissues showing visible symptoms thus indicating a latent stage in the life cycle of the pathogen.
Stagonosporopsis tanaceti infected the cauline and petiolate leaves, crown tissues, flower stems, flower buds and rays of the flower but not the roots of pyrethrum plants. The necrotic region of flower stems extended from the peduncle to 8-11 cm down the flower stems where the epidermis, hypodermis and cortical tissues were degraded. Pycnidia that developed in the necrotic tissue of flower stems released pycnidiospores, which dispersed through wind and water-splash and then presumably settled onto the flower buds and infected the flower rays before infecting the developing seed. Pycnidia that also formed on the infected foliage released pycnidiospores that were then deposited, by water splash dispersal to the region of the crown tissue where the petioles emerged. At this point the spores germinated and infected the parenchyma cells of the hypodermis and cortical tissues of the crown. Throughout the infection cycle, vascular tissues of all plant organs were not colonised with the endodermis acting as a barrier to hyphal infection. The results of the infection and colonisation of various plant tissues has enabled a complete disease cycle of ray blight in pyrethrum to be described.
The effect of S. tanaceti on growth and development of pyrethrum was studied in two glasshouse trials where the first trial…
Subjects/Keywords: ray blight; pyrethrum; TaqMan PCR; latent infection
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Bhuiyan, M. A. B. (2017). Biology and host-pathogen interaction of Stagonosporopsis tanaceti, the cause of ray blight in pyrethrum. (Doctoral Dissertation). University of Melbourne. Retrieved from http://hdl.handle.net/11343/192512
Chicago Manual of Style (16th Edition):
Bhuiyan, Md Abdullahil Baki. “Biology and host-pathogen interaction of Stagonosporopsis tanaceti, the cause of ray blight in pyrethrum.” 2017. Doctoral Dissertation, University of Melbourne. Accessed January 22, 2021.
http://hdl.handle.net/11343/192512.
MLA Handbook (7th Edition):
Bhuiyan, Md Abdullahil Baki. “Biology and host-pathogen interaction of Stagonosporopsis tanaceti, the cause of ray blight in pyrethrum.” 2017. Web. 22 Jan 2021.
Vancouver:
Bhuiyan MAB. Biology and host-pathogen interaction of Stagonosporopsis tanaceti, the cause of ray blight in pyrethrum. [Internet] [Doctoral dissertation]. University of Melbourne; 2017. [cited 2021 Jan 22].
Available from: http://hdl.handle.net/11343/192512.
Council of Science Editors:
Bhuiyan MAB. Biology and host-pathogen interaction of Stagonosporopsis tanaceti, the cause of ray blight in pyrethrum. [Doctoral Dissertation]. University of Melbourne; 2017. Available from: http://hdl.handle.net/11343/192512

University of Edinburgh
4.
Al-Harbi, Adel Mohanna.
Challenges of tuberculosis prevention through early detection of latent tuberculosis infection in new immigrants to the State of Kuwait.
Degree: PhD, 2012, University of Edinburgh
URL: http://hdl.handle.net/1842/8939
► Introduction: Despite management advances worldwide, tuberculosis still remains a serious uncontrolled disease. The absence of either a ‘gold’ standard diagnostic test, or a conventional rapid…
(more)
▼ Introduction: Despite management advances worldwide, tuberculosis still remains a serious uncontrolled disease. The absence of either a ‘gold’ standard diagnostic test, or a conventional rapid ‘reference’ laboratory test for asymptomatic Mycobacterium tuberculosis (MTB) carriers complicates disease control. Through mandatory screening of high-risk groups, early diagnosis of latent tuberculosis infection (LTBI) cases allows recognition and better control of the tuberculosis pandemic. Materials and Methods: The current tuberculosis screening guidelines as recommended by the World Health Organization, chest X-ray and tuberculin skin test were assessed and revealed rises in TB morbidity and fatality trends in the Kuwait population (low incidence country). In order to evaluate options for LTBI diagnosis, the current work implemented a 4-month prospective, observational, repeated-measure and randomly implemented survey on 180 new immigrants to Kuwait using a structured risk factor questionnaire whilst, simultaneously evaluating the performance of the two standard diagnostics (chest X-ray and tuberculin skin test) with the new biomarker interferon gamma release assays (T-SPOT .TB test and QuantiFERON Gold In-Tube test (QNF-GIT)); which detect the release of interferon gamma (INF-γ) released from sensitization to specific MTB antigens. Results: Associations between various epidemiological risk factors - such as socio-demographic status, smoking and environmental exposure-contact - were associated in the laboratory diagnosed LTBI participants. Positive identification of LTBI prevalence detected by two radiologists was 10.1% having ‘moderate’ inter-reader agreement (Kappa = 0.505), compared to no positives being detected by three pulmonologists. TST results were negative (less than 10-mm ‘cut-off’) even in the 86.1% Bacillus Calmette-Guérin vaccinated expatriates. Estimated LTBI using QNFGIT was 28.3% compared to 41.1% positive T-SPOT .TB test. Both interferon gamma assays revealed concordant ‘abnormal’ results in 26.1% with ‘good’ agreement (kappa = 0.627). Conclusion: Detection of latent tuberculosis infection can be facilitated by introducing evidence-based diagnostic classification depending on history taking of epidemiological-related risk factors and chest X-ray plus either interferon gamma assays.
Subjects/Keywords: 616.99; tuberculosis; latent tuberculosis infection; TST; IGRA
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APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Al-Harbi, A. M. (2012). Challenges of tuberculosis prevention through early detection of latent tuberculosis infection in new immigrants to the State of Kuwait. (Doctoral Dissertation). University of Edinburgh. Retrieved from http://hdl.handle.net/1842/8939
Chicago Manual of Style (16th Edition):
Al-Harbi, Adel Mohanna. “Challenges of tuberculosis prevention through early detection of latent tuberculosis infection in new immigrants to the State of Kuwait.” 2012. Doctoral Dissertation, University of Edinburgh. Accessed January 22, 2021.
http://hdl.handle.net/1842/8939.
MLA Handbook (7th Edition):
Al-Harbi, Adel Mohanna. “Challenges of tuberculosis prevention through early detection of latent tuberculosis infection in new immigrants to the State of Kuwait.” 2012. Web. 22 Jan 2021.
Vancouver:
Al-Harbi AM. Challenges of tuberculosis prevention through early detection of latent tuberculosis infection in new immigrants to the State of Kuwait. [Internet] [Doctoral dissertation]. University of Edinburgh; 2012. [cited 2021 Jan 22].
Available from: http://hdl.handle.net/1842/8939.
Council of Science Editors:
Al-Harbi AM. Challenges of tuberculosis prevention through early detection of latent tuberculosis infection in new immigrants to the State of Kuwait. [Doctoral Dissertation]. University of Edinburgh; 2012. Available from: http://hdl.handle.net/1842/8939

Georgia State University
5.
Barron, Marissa M.
Diabetes Mellitus is Associated with Increased Prevalence of Latent Tuberculosis Infection: Findings from the National Health and Nutrition Examination Survey, 2011-2012.
Degree: MPH, Public Health, 2017, Georgia State University
URL: https://scholarworks.gsu.edu/iph_theses/545
► Background: Type 2 diabetes mellitus is associated with threefold higher risks of active tuberculosis (TB) and an estimated 15% of the 10.4 million annual…
(more)
▼ Background: Type 2 diabetes mellitus is associated with threefold higher risks of active tuberculosis (TB) and an estimated 15% of the 10.4 million annual incident TB cases are attributable to diabetes. While the relationship between diabetes and TB disease is well-established, little is known about the association between diabetes and
latent TB
infection (LTBI).
Methods: We performed a cross-sectional analysis of data from the 2011-2012 cycle of the National Health and Nutrition Examination Survey. Participants aged ³20 years were eligible for this analysis. Diabetes status was defined by glycated hemoglobin (HbA1c) as no diabetes (£5.6%), prediabetes (5.7-6.4%), and diabetes (³6.5%); participants were defined as having diabetes if they self-reported a diagnosis, regardless of HbA1c. LTBI was defined by interferon gamma release assay (IGRA) as positive, negative, or indeterminate. We used logistic regression to estimate the adjusted odds ratio and 95% confidence interval of LTBI comparing participants with diabetes and prediabetes to those with no diabetes.
Results: Overall the prevalence of diabetes was 11.4% (95%CI 9.8-13.0%) and 22.1% (95%CI 20.5-23.8%) had prediabetes. The prevalence of LTBI was 5.9% (95%CI 4.9-7.0%). After adjusting for cofounding factors, the odds of prevalent LTBI was greater among adults with diabetes (aOR 1.91, 95%CI 1.16-3.16) compared to those without diabetes.
Conclusion: Diabetes is associated with LTBI among adults in the US, even after adjusting for confounding factors. Given diabetes increases the risk of active TB, patients with co-prevalent diabetes and LTBI may be targeted for LTBI treatment.
Advisors/Committee Members: Dr. Matthew J. Magee, Dr. Kate M. Shaw.
Subjects/Keywords: latent tuberculosis infection; diabetes mellitus; obesity; tuberculosis
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APA ·
Chicago ·
MLA ·
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CSE |
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to Zotero / EndNote / Reference
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APA (6th Edition):
Barron, M. M. (2017). Diabetes Mellitus is Associated with Increased Prevalence of Latent Tuberculosis Infection: Findings from the National Health and Nutrition Examination Survey, 2011-2012. (Thesis). Georgia State University. Retrieved from https://scholarworks.gsu.edu/iph_theses/545
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Barron, Marissa M. “Diabetes Mellitus is Associated with Increased Prevalence of Latent Tuberculosis Infection: Findings from the National Health and Nutrition Examination Survey, 2011-2012.” 2017. Thesis, Georgia State University. Accessed January 22, 2021.
https://scholarworks.gsu.edu/iph_theses/545.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Barron, Marissa M. “Diabetes Mellitus is Associated with Increased Prevalence of Latent Tuberculosis Infection: Findings from the National Health and Nutrition Examination Survey, 2011-2012.” 2017. Web. 22 Jan 2021.
Vancouver:
Barron MM. Diabetes Mellitus is Associated with Increased Prevalence of Latent Tuberculosis Infection: Findings from the National Health and Nutrition Examination Survey, 2011-2012. [Internet] [Thesis]. Georgia State University; 2017. [cited 2021 Jan 22].
Available from: https://scholarworks.gsu.edu/iph_theses/545.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Barron MM. Diabetes Mellitus is Associated with Increased Prevalence of Latent Tuberculosis Infection: Findings from the National Health and Nutrition Examination Survey, 2011-2012. [Thesis]. Georgia State University; 2017. Available from: https://scholarworks.gsu.edu/iph_theses/545
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Washington
6.
Ledesma, Jorge Ricardo.
Interferon-gamma release assay levels and risk of progression to active tuberculosis: a systematic review and dose-response meta-regression analysis.
Degree: 2020, University of Washington
URL: http://hdl.handle.net/1773/46323
► Objective: To summarize and quantify the dose-response relationship between interferon-gamma release assay (IGRA) levels and the risk of progression to active tuberculosis (TB) Design: Systematic…
(more)
▼ Objective: To summarize and quantify the dose-response relationship between interferon-gamma release assay (IGRA) levels and the risk of progression to active tuberculosis (TB) Design: Systematic review and Bayesian dose-response meta-regression Data sources: PubMed and Embase from 2001 to 10 May 2020, and references from relevant systematic reviews. Eligibility criteria and data analysis: Retrospective or prospective cohort studies and clinical trials that followed individuals over time to assess the relationship between IGRA levels and risk of developing TB were included. Study results related to incident TB were extracted and two authors independently assessed the quality of included studies using the Newcastle-Ottawa scale (NOS). Data were pooled using a novel Bayesian meta-regression method to generate a dose-response risk curve. Results: 34 of 1,074 identified studies met the criteria for inclusion in the analysis. Higher levels of interferon-gamma were associated with increased risk of progression to active tuberculosis. In the dose-response curve, the risk increased sharply between interferon-gamma levels 0 and 5 IU/ml, after which the risk continued to increase moderately but at a slower pace until reaching about 15 IU/ml where the risk levels off. Compared to 0 IU/ml, the relative risk of progression to active TB among those with interferon-gamma levels of 0.35, 1, 5, 10, 15, and 20 IU/ml were: 1.67 (1.30 – 2.13), 2.91 (2.12 – 3.96), 10.13 (5.57 – 14.57), 16.42 (11.07 – 23.44), 19.11 (13.01 – 27.82), and 19.65 (13.52 – 28.82), respectively. The dose-response relationship remains consistent when limiting the analysis to studies that scored high in the NOS. Conclusions: The current practice of dichotomizing IGRA test results simplifies the TB
infection disease continuum. Evaluating the IGRA test results over a continuous scale could enable the identification of individuals at greatest risk of progression to active TB.
Advisors/Committee Members: Kyu, Hmwe H (advisor).
Subjects/Keywords: IGRA; Latent Tuberculosis Infection; Risk; Tuberculosis; Health sciences; Global Health
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Ledesma, J. R. (2020). Interferon-gamma release assay levels and risk of progression to active tuberculosis: a systematic review and dose-response meta-regression analysis. (Thesis). University of Washington. Retrieved from http://hdl.handle.net/1773/46323
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Ledesma, Jorge Ricardo. “Interferon-gamma release assay levels and risk of progression to active tuberculosis: a systematic review and dose-response meta-regression analysis.” 2020. Thesis, University of Washington. Accessed January 22, 2021.
http://hdl.handle.net/1773/46323.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Ledesma, Jorge Ricardo. “Interferon-gamma release assay levels and risk of progression to active tuberculosis: a systematic review and dose-response meta-regression analysis.” 2020. Web. 22 Jan 2021.
Vancouver:
Ledesma JR. Interferon-gamma release assay levels and risk of progression to active tuberculosis: a systematic review and dose-response meta-regression analysis. [Internet] [Thesis]. University of Washington; 2020. [cited 2021 Jan 22].
Available from: http://hdl.handle.net/1773/46323.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Ledesma JR. Interferon-gamma release assay levels and risk of progression to active tuberculosis: a systematic review and dose-response meta-regression analysis. [Thesis]. University of Washington; 2020. Available from: http://hdl.handle.net/1773/46323
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Georgia State University
7.
Wang, Zanju.
Latent Tuberculosis Infection among Immigrant and Refugee Children Aged 2-14 Years Who Arrived in the United States in 2008-2012.
Degree: MPH, Public Health, 2015, Georgia State University
URL: https://scholarworks.gsu.edu/iph_theses/411
► Abstract Background: According to Centers for Disease Control and Prevention (CDC) tuberculosis (TB) report TB case rate dropped from 3.2 to 3.0 per 100,000…
(more)
▼ Abstract
Background: According to Centers for Disease Control and Prevention (CDC) tuberculosis (TB) report TB case rate dropped from 3.2 to 3.0 per 100,000 person in 2013 in the U.S, which was a 4.3% decrease from 2012, but the proportion of total cases occurring in foreign-born persons reached to 65% of the national case total. This proportion has been increasing since 1993. Studies found that progression of
latent tuberculosis
infection (LTBI) to active TB (reactivation TB) contributed a large proportion to TB cases among foreign-born persons and posed a huge challenge to TB elimination in the U.S. The Division of Global Migration and Quarantine (DGMQ) in CDC provides Tuberculosis Screening and Treatment Technical Instructions (TB TI) for U.S.-bound immigrant and refugee overseas medical screening. The 2007 TB TI made several changes to enhance overseas medical screening for TB. One of them is requiring applicants aged 2-14 years who live in countries with a World Health Organization (WHO)-estimated TB incidence rate equal or higher than 20 cases per 100,000 population to have a tuberculin skin test (TST) or interferon gamma release assay (IGRA) to detect TB/LTBI.
Objectives: To assess LTBI prevalence among immigrant and refugee children aged 2-14 years who arrived in the United States in 2008-2012 and to explore demographic and geographic predictors among LTBI cases.
Methods: Using DGMQ data from 2008-2012, LTBI prevalence was calculated. Regression analyses were used to examine predictors of LTBI risk based upon geographic and select demographic characteristics (country of origin, sex, country-specific LTBI prevalence rate).
Results:LTBI prevalence of all 199 immigrant and refugee arrival countries vs top 16 arrival countries were 6.30% and 8.76%, respectively. Top 16 arrival countries contributed to 68.40% arrivals but contributed to 95.08% of LTBI cases. LTBI prevalence of both populations showed an increasing trend in 2008-2012. The highest five prevalence countries were the Philippines (42.74%) Vietnam (9.35%), Mexico (8.71%), Bhutan (8.31%) and China (7.80%). Regression coefficient estimates (i.e., log odds) for country of origin predictor were significant (p
Conclusions: Diagnosing and treating LTBI and continuing the battle against TB globally are critical to TB elimination in the U.S. 2007 TB TI has contributed to detecting LTBI cases, should be implemented vigorously in immigrant and refugee overseas medical screening. Receiving states should address their follow-up gaps to ensure the completion of TB/LTBI treatment. Resources need to be allocated properly to states with high TB/LTBI burden.
Advisors/Committee Members: Dr. Ruiyan Luo, Dr. Sheryl Strasser.
Subjects/Keywords: tuberculosis; TB; latent tuberculosis infection; LTBI; immigrant; refugee; children
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APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
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APA (6th Edition):
Wang, Z. (2015). Latent Tuberculosis Infection among Immigrant and Refugee Children Aged 2-14 Years Who Arrived in the United States in 2008-2012. (Thesis). Georgia State University. Retrieved from https://scholarworks.gsu.edu/iph_theses/411
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Wang, Zanju. “Latent Tuberculosis Infection among Immigrant and Refugee Children Aged 2-14 Years Who Arrived in the United States in 2008-2012.” 2015. Thesis, Georgia State University. Accessed January 22, 2021.
https://scholarworks.gsu.edu/iph_theses/411.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Wang, Zanju. “Latent Tuberculosis Infection among Immigrant and Refugee Children Aged 2-14 Years Who Arrived in the United States in 2008-2012.” 2015. Web. 22 Jan 2021.
Vancouver:
Wang Z. Latent Tuberculosis Infection among Immigrant and Refugee Children Aged 2-14 Years Who Arrived in the United States in 2008-2012. [Internet] [Thesis]. Georgia State University; 2015. [cited 2021 Jan 22].
Available from: https://scholarworks.gsu.edu/iph_theses/411.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Wang Z. Latent Tuberculosis Infection among Immigrant and Refugee Children Aged 2-14 Years Who Arrived in the United States in 2008-2012. [Thesis]. Georgia State University; 2015. Available from: https://scholarworks.gsu.edu/iph_theses/411
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
8.
Marathe, Gayatri Jayant.
LATENT TUBERCULOSIS SCREENING IN HIV-INFECTED WOMEN AT ANTENATAL CLINIC AND ANTI-RETROVIRAL THERAPY CENTER IN AN URBAN HOSPITAL IN INDIA.
Degree: 2014, Johns Hopkins University
URL: http://jhir.library.jhu.edu/handle/1774.2/38049
► Background: HIV-infected women have increased risk of reactivation of latent TB infection, making screening crucial. There are limited guidelines for latent TB screening in India.…
(more)
▼ Background: HIV-infected women have increased risk of reactivation of latent TB infection, making screening crucial. There are limited guidelines for latent TB screening in India. There is need to study the two available tests, which are known to be compromised in this population - Tuberculin Skin test (TST) and Quantiferon Gold-in-Tube assay (QGIT). Thus, our aim was to evaluate the performance of these two tests in two facilities – Antenatal Clinic (ANC) and Antiretroviral Therapy Center (ARTC). Methodology: We conducted a cross-sectional study of HIV-infected women seeking care at the ANC and ARTC within a government hospital in Pune, India. Trained staff administered sociodemographic/medical history questionnaires before TST and QGIT testing. The percent positivity, percent agreement between tests results and kappa statistic, were calculated. Multivariate logistic regression was used to study risk factors for TST and QGIT positivity. Finally for each test, the
number needed to screen (NNS) inorder to avert one TB case, was estimated in each facility. Results: Among ANC participants, 15 (11%) were TST+ and 40 (29 %) were QGIT+, with 73.2 % agreement (95% CI = 63.2-81.4, k = 0.214 (0.04 - 0.39)). Among ARTC participants, 22 (15.1 %) were TST+ and 69 (47.2 %) were QGIT+, with 62.1 % agreement (95% CI = 52-71, k=0.22 (0.09-0.34)). TST-/QGIT+ discordance was common in both groups (21% ANC, 34% ARTC). It was observed in the ANC that NNS estimate is 200 for TST alone and 73 for QGIT alone. Similarly in ARTC TST alone has an NNS of 147 compared to 47 for QGIT alone. Conclusions: The QGIT estimated a higher prevalence of LTBI as compared to TST in both facilities, more comparable to the Revised National TB Control Programme estimate of 30-40 %. Further advantage of using QGIT is the less than half of NNS estimate of TST alone in both settings. Thus there is need for development and evaluation of an algorithm with QGIT alone or two test strategy
with both TST and QGIT in these settings, considering the issues with both the tests in this population.
Subjects/Keywords: Latent Tuberculosis infection;
HIV infection;
Pregnancy;
Antenatal Clinic;
Anti-retroviral Therapy Center;
Tuberculin Skin Test;
Interferon gamma release assay
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APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Marathe, G. J. (2014). LATENT TUBERCULOSIS SCREENING IN HIV-INFECTED WOMEN AT ANTENATAL CLINIC AND ANTI-RETROVIRAL THERAPY CENTER IN AN URBAN HOSPITAL IN INDIA. (Thesis). Johns Hopkins University. Retrieved from http://jhir.library.jhu.edu/handle/1774.2/38049
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Marathe, Gayatri Jayant. “LATENT TUBERCULOSIS SCREENING IN HIV-INFECTED WOMEN AT ANTENATAL CLINIC AND ANTI-RETROVIRAL THERAPY CENTER IN AN URBAN HOSPITAL IN INDIA.” 2014. Thesis, Johns Hopkins University. Accessed January 22, 2021.
http://jhir.library.jhu.edu/handle/1774.2/38049.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Marathe, Gayatri Jayant. “LATENT TUBERCULOSIS SCREENING IN HIV-INFECTED WOMEN AT ANTENATAL CLINIC AND ANTI-RETROVIRAL THERAPY CENTER IN AN URBAN HOSPITAL IN INDIA.” 2014. Web. 22 Jan 2021.
Vancouver:
Marathe GJ. LATENT TUBERCULOSIS SCREENING IN HIV-INFECTED WOMEN AT ANTENATAL CLINIC AND ANTI-RETROVIRAL THERAPY CENTER IN AN URBAN HOSPITAL IN INDIA. [Internet] [Thesis]. Johns Hopkins University; 2014. [cited 2021 Jan 22].
Available from: http://jhir.library.jhu.edu/handle/1774.2/38049.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Marathe GJ. LATENT TUBERCULOSIS SCREENING IN HIV-INFECTED WOMEN AT ANTENATAL CLINIC AND ANTI-RETROVIRAL THERAPY CENTER IN AN URBAN HOSPITAL IN INDIA. [Thesis]. Johns Hopkins University; 2014. Available from: http://jhir.library.jhu.edu/handle/1774.2/38049
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of California – Berkeley
9.
Metcalfe, John.
Critical Evaluation of Tuberculosis Diagnostic Tests in Low- and High-Burden Settings.
Degree: Epidemiology, 2012, University of California – Berkeley
URL: http://www.escholarship.org/uc/item/2tk4j5tg
► Tuberculosis (TB) is the second leading cause of death from an infectious disease worldwide and remains a major public health challenge, particularly in resource limited…
(more)
▼ Tuberculosis (TB) is the second leading cause of death from an infectious disease worldwide and remains a major public health challenge, particularly in resource limited settings. Given the effectiveness of current treatment regimens, enhanced detection of disease in both low- and high-burden settings will be critical in making progress towards TB elimination.As TB case rates have declined in high-income settings, TB control has centered on finding and treating individuals with non-infectious latent TB infection (LTBI) in order to prevent reactivation infectious TB disease. Since 2005, the Centers for Disease Control and Prevention has recommended use of interferon-gamma release assays (IGRAs), in vitro immuno-diagnostic tests that measure effector T-cell mediated interferon-gamma (IFN-gamma) response to M. tuberculosis specific antigens, could be used for targeted screening of LTBI in all circumstances in which the tuberculin skin test (TST) is used. We found that higher quantitative IFN-gamma results were associated with active tuberculosis and added clinical value to a prediction model incorporating conventional risk factors; however, in all settings and especially within low- and middle-income countries, IGRAs are inadequate rule-out or rule-in tests for active TB. Although IGRAs are widely used in high-income countries and numerous studies have evaluated their diagnostic performance for detection of LTBI, there is limited data on the precision of IGRA results. In the largest precision study of an IGRA to date, we found considerable variability in TB response measured by QuantiFERON-TB Gold In-Tube (QFT-GIT, Cellestis, Australia); test results should be interpreted cautiously among low-risk individuals with positive TB response less than 0.59 IU/ml.In contrast to low TB burden, high income settings, TB control in low income settings focuses on early detection and treatment of individuals with active, infectious TB. In the WHO African Region, the incidence of multidrug resistant TB (MDR-TB) has tripled in the past 20 years and poses a major risk to regional TB control programs. Accurate, timely, and affordable drug susceptibility testing for patient management and in support of surveillance programs is urgently needed. In a politically unstable, high HIV prevalence region of southern Africa, we validated use of a low-cost, accelerated phenotypic method for MDR-TB detection, and provide the first report of the prevalence of MDR-TB from this country in 17 years.
Subjects/Keywords: Epidemiology; Diagnostic tests; interferon-gamma release assays; latent tuberculosis infection; Mycobacterium tuberculosis; tuberculosis
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Metcalfe, J. (2012). Critical Evaluation of Tuberculosis Diagnostic Tests in Low- and High-Burden Settings. (Thesis). University of California – Berkeley. Retrieved from http://www.escholarship.org/uc/item/2tk4j5tg
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Metcalfe, John. “Critical Evaluation of Tuberculosis Diagnostic Tests in Low- and High-Burden Settings.” 2012. Thesis, University of California – Berkeley. Accessed January 22, 2021.
http://www.escholarship.org/uc/item/2tk4j5tg.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Metcalfe, John. “Critical Evaluation of Tuberculosis Diagnostic Tests in Low- and High-Burden Settings.” 2012. Web. 22 Jan 2021.
Vancouver:
Metcalfe J. Critical Evaluation of Tuberculosis Diagnostic Tests in Low- and High-Burden Settings. [Internet] [Thesis]. University of California – Berkeley; 2012. [cited 2021 Jan 22].
Available from: http://www.escholarship.org/uc/item/2tk4j5tg.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Metcalfe J. Critical Evaluation of Tuberculosis Diagnostic Tests in Low- and High-Burden Settings. [Thesis]. University of California – Berkeley; 2012. Available from: http://www.escholarship.org/uc/item/2tk4j5tg
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
10.
Bastos, Gisele Medeiros.
Papel da proteína HspX do Mycobacterium tuberculosis na regulação de genes relacionados à adaptação morfológica de micobactérias ao período de dormência, utilizando Mycobacterium smegmatis como organismo modelo.
Degree: PhD, Análises Clínicas, 2013, University of São Paulo
URL: http://www.teses.usp.br/teses/disponiveis/9/9136/tde-25042013-152531/
;
► A manutenção da infecção latente pelo M. tuberculosis (TBIL) pode ser atribuída à sua capacidade de sobreviver durante anos no organismo humano em um estado…
(more)
▼ A manutenção da infecção latente pelo M. tuberculosis (TBIL) pode ser atribuída à sua capacidade de sobreviver durante anos no organismo humano em um estado não replicativo (dormente). A proteína HspX do M. tuberculosis, induzida sob condições de hipóxia, está fortemente associada com a manutenção da viabilidade do bacilo na TBIL. O presente estudo tem como objetivo, verificar se a superexpressão da proteína HspX altera a expressão de genes envolvidos com a síntese de componentes da parede celular, replicação do DNA e divisão celular de bacilos, assim como, na expressão de genes envolvidos com a resposta imune inata em macrófagos infectados com esses bacilos. O gene hspX foi amplificado pela PCR a partir do DNA do M. tuberculosis H37Rv, clonado no vetor de expressão pFPCA1GFP, e a proteína HspX expressa em M. smegmatis mc2155. As bactérias, nas quais, a presença da proteína recombinante foi confirmada por Western Blot, foram utilizadas, para a análise de expressão gênica tanto em bactérias quanto em macrófagos infectados. O estudo de expressão gênica foi realizado utilizando a RT-qPCR. Quando comparado aos controles, as bactérias que expressavam a proteína HspX apresentaram uma redução na expressão de genes de replicação do DNA e divisão celular, que foi acompanhado por uma tendência a filamentação das células e uma redução no tamanho das colônias. Além disso, nos macrófagos infectados com a bactéria expressando a proteína HspX, houve um aumento tanto da expressão do mRNA quanto da secreção de IL-1b, citocina importante para estabilização do granuloma, e uma redução na expressão de IRGM, gene relacionado com o processo autofágico, importante mecanismo de defesa do hospedeiro contra bactérias intracelulares. Portanto, em conjunto, essas alterações de expressão gênica, em consequência da presença da proteína HspX sugerem uma contribuição, direta ou indireta, dessa proteína para a adaptação morfológica e metabólica da bactéria dormente durante a TBIL, e consequentemente, para a resposta imune inata dos macrófagos infectados favorecendo a viabilidade intracelular dessas bactérias.
The maintenance of Mycobacterium tuberculosis infection latent (TBIL) may be attributed to its ability to persist for years in the host in a non-replicative state (dormant). The HspX protein from M. tuberculosis, induced under hypoxic, is strongly associated with maintaining the bacillus viability in TBIL. This study aims to determine if HspX overexpression chances the expression of genes involved in the synthesis of cell wall components, DNA replication and cell division of bacilli, as well as, the expression of genes involved in innate immune response of macrophages infected. The gene hspX was amplified by PCR from DNA of M. tuberculosis H37Rv, and cloned into the expression vector pFPCA1GFP. The HspX was expressed in M. smegmatis mc2155 and the recombinant protein was confirmed by Western blot. The bacterias expressing HspX were used for gene expression analysis both in bacteria and in infected macrophages by RT-PCRq. In bacterias…
Advisors/Committee Members: Hirata, Mario Hiroyuki.
Subjects/Keywords: Expressão gênica; Gene expression; Infecção latente; Latent infection; Mycobacterium tuberculosis; Mycobacterium tuberculosis
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Bastos, G. M. (2013). Papel da proteína HspX do Mycobacterium tuberculosis na regulação de genes relacionados à adaptação morfológica de micobactérias ao período de dormência, utilizando Mycobacterium smegmatis como organismo modelo. (Doctoral Dissertation). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/9/9136/tde-25042013-152531/ ;
Chicago Manual of Style (16th Edition):
Bastos, Gisele Medeiros. “Papel da proteína HspX do Mycobacterium tuberculosis na regulação de genes relacionados à adaptação morfológica de micobactérias ao período de dormência, utilizando Mycobacterium smegmatis como organismo modelo.” 2013. Doctoral Dissertation, University of São Paulo. Accessed January 22, 2021.
http://www.teses.usp.br/teses/disponiveis/9/9136/tde-25042013-152531/ ;.
MLA Handbook (7th Edition):
Bastos, Gisele Medeiros. “Papel da proteína HspX do Mycobacterium tuberculosis na regulação de genes relacionados à adaptação morfológica de micobactérias ao período de dormência, utilizando Mycobacterium smegmatis como organismo modelo.” 2013. Web. 22 Jan 2021.
Vancouver:
Bastos GM. Papel da proteína HspX do Mycobacterium tuberculosis na regulação de genes relacionados à adaptação morfológica de micobactérias ao período de dormência, utilizando Mycobacterium smegmatis como organismo modelo. [Internet] [Doctoral dissertation]. University of São Paulo; 2013. [cited 2021 Jan 22].
Available from: http://www.teses.usp.br/teses/disponiveis/9/9136/tde-25042013-152531/ ;.
Council of Science Editors:
Bastos GM. Papel da proteína HspX do Mycobacterium tuberculosis na regulação de genes relacionados à adaptação morfológica de micobactérias ao período de dormência, utilizando Mycobacterium smegmatis como organismo modelo. [Doctoral Dissertation]. University of São Paulo; 2013. Available from: http://www.teses.usp.br/teses/disponiveis/9/9136/tde-25042013-152531/ ;

University of Michigan
11.
McNamara, Lucy Alexandra.
HIV-1 Infection of Hematopoietic Progenitor Cells.
Degree: PhD, Microbiology & Immunology, 2012, University of Michigan
URL: http://hdl.handle.net/2027.42/96161
► Latent HIV infection allows virus to persist in HIV-infected individuals in spite of antiretroviral therapy. In addition to the well-studied reservoir of latent virus in…
(more)
▼ Latent HIV
infection allows virus to persist in HIV-infected individuals in spite of antiretroviral therapy. In addition to the well-studied reservoir of
latent virus in resting memory CD4+ T cells, we have recently proposed that hematopoietic progenitor cells (HPCs) in the bone marrow serve as a reservoir for
latent HIV. Here, I first investigate whether HIV envelope tropism impacts the ability of the virus to infect different types of HPCs. I find that HIV envelopes that are able to use CXCR4 as a co-receptor permit
infection of immature, multipotent HPCs defined by expression of the cell surface marker CD133, whereas CCR5-tropic HIV has a greatly reduced capacity to infect these cells. Furthermore, I find that a CXCR4-tropic HIV envelope can infect hematopoietic stem cells that support long-term, multilineage engraftment in mice. As hematopoietic stem cells can live for the entire lifespan of a person,
latent HIV
infection of these cells could create a very long-lived reservoir of virus. I next examine the cellular factors that promote latency in HPCs and find that HIV can establish a
latent infection in multiple HPC subsets, including immature HPCs.
Latent infection in these cells can be reversed by activation of the transcription factor NF-kappaB as well as by inhibition of histone deacetylases. Finally, I investigate whether the CD133+ subset of HPCs harbors HIV genomes in HAART-treated patients with undetectable viral loads. I detect HIV genomes in CD133-sorted cell populations in 6 of 11 donors, including two donors who have had undetectable viral loads for more than 8 years. Furthermore, for at least 5 of these 6 donors I demonstrate that CD3+ T cells are present at extremely low levels in the CD133-sorted populations and are therefore unlikely to contribute to the HIV DNA detected in these samples. Together, these findings illuminate the potential of long-lived, CD133+ HPCs to serve as a reservoir for
latent virus in HIV-infected individuals. Further study of how
latent infection in HPCs and T cells can be reversed to eliminate these viral reservoirs may lead us closer to a cure for HIV.
Advisors/Committee Members: Collins, Kathleen L. (committee member), Moran, John V. (committee member), Telesnitsky, Alice (committee member), Ono, Akira (committee member).
Subjects/Keywords: HIV; Latent Infection; HIV Reservoirs; HIV Coreceptor Tropism; Microbiology and Immunology; Health Sciences
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
McNamara, L. A. (2012). HIV-1 Infection of Hematopoietic Progenitor Cells. (Doctoral Dissertation). University of Michigan. Retrieved from http://hdl.handle.net/2027.42/96161
Chicago Manual of Style (16th Edition):
McNamara, Lucy Alexandra. “HIV-1 Infection of Hematopoietic Progenitor Cells.” 2012. Doctoral Dissertation, University of Michigan. Accessed January 22, 2021.
http://hdl.handle.net/2027.42/96161.
MLA Handbook (7th Edition):
McNamara, Lucy Alexandra. “HIV-1 Infection of Hematopoietic Progenitor Cells.” 2012. Web. 22 Jan 2021.
Vancouver:
McNamara LA. HIV-1 Infection of Hematopoietic Progenitor Cells. [Internet] [Doctoral dissertation]. University of Michigan; 2012. [cited 2021 Jan 22].
Available from: http://hdl.handle.net/2027.42/96161.
Council of Science Editors:
McNamara LA. HIV-1 Infection of Hematopoietic Progenitor Cells. [Doctoral Dissertation]. University of Michigan; 2012. Available from: http://hdl.handle.net/2027.42/96161
12.
이, 선홍.
Prevalence and Risk factors of Latent Tuberculosis Infection among Healthcare Workers.
Degree: 2019, Ajou University
URL: http://repository.ajou.ac.kr/handle/201003/17874
;
http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000028490
► BACKGROUND: Healthcare worker(HCW) has an increased risk for tuberculosis (TB) infection by occupational exposure. Recently, Korean government recommended diagnosis and treatment of latent tuberculosis infection…
(more)
▼ BACKGROUND: Healthcare worker(HCW) has an increased risk for tuberculosis (TB) infection by occupational exposure. Recently, Korean government recommended diagnosis and treatment of latent tuberculosis infection (LTBI) for HCWs who work at high-risk TB environment to control TB. This study was conducted to assess the prevalence and risk factors of LTBI and to estimate cumulative risk of active TB in HCWs.
METHODS: We conducted a cross-sectional study using a standard questionnaire and interferon gamma-release assay (IGRA) among HCWs in a teaching hospital. Biographical information for workplace, periods and interdepartment rotation were collected from electronic database. The predicted cumulative of active TB in HCWs with LTBI was evaluated based on a computerized algorithm.
RESULTS: Of a total of 1,407 HCWs, 138 HCWs had a positive IGRA results and prevalence of 9.8% [95% confidence interval (CI) 8.2 – 11.4]. In the univariate analysis, age, BCG vaccination, comorbidity, total working period and job positions were significant risk factors for LTBI (P value < 0.001, respectively). The prevalence of LTBI was significantly increased with age (P value < 0.001). However, working periods in TB-related department was not associated with LTBI (P value = 0.369). In the multivariate analysis, age of ≥ 50 years [odds ratio (OR) 7.522, 95% CI 3.56–15.89], job of nursing assistant (OR 2.912, 95%CI 1.283-6.608) and working periods in department in which has a low probability to care for patients with active respiratory tuberculosis, of >1 to ≤5 years (OR 1.794, 95% CI 1.029-3.130) were significantly associated with increased risk of LTBI. Median cumulative risk of active TB with LTBI was estimated to be 4.31% [interquartile range (IQR) 3.43–5.29] and 4.41% (IQR 3.14 – 5.29) in HCWs with and without experience of working in TB-related department, respectively and there was no significant difference between two groups(p = 0.715).
CONCLUSIONS: The prevalence of LTBI among HCWs might be not higher than that in general population. Given identified risk factors of LTBI and cumulative risk of active TB in HCWs, it is necessary to edit current treatment recommendation for LTBI in which risk for LTBI is classified by working department.
배경 및 목적: 의료기관종사자는 직업적 노출로 인해 결핵감염의 위험이 높다. 최근 발표된 정부정책은 결핵관리 전략으로 결핵 전파의 고위험부서에서 일하는 의료기관종사자의 잠복결핵감염을 진단하고 치료 하도록 권고하고 있다. 본 연구를 통해 정부에서 제시한 위험군 분류에 따른 치료 적용의 적절성을 검토하기 위하여 의료기관종사자의 잠복결핵 감염의 위험인자와 유병률을 평가하고 활동성 결핵감염의 누적위험도를 추정하였다.
대상 및 방법: 아주대학교 병원에 근무하는 의료기관종사자 1407명을 대상으로 설문조사, 흉부방사선검사 및 인터페론감마 방출검사를 이용 하여 단면 연구를 시행하였다. 업무부서, 부서별 근무기간, 부서간 이동 정보는 전자 데이터베이스를 통해 수집되었다. 잠복결핵감염으로 진단된 의료기관 종사자에서 활동성 결핵으로 이행하는 누적 예측 위험도는 전산화된 알고리듬을 통해 고안된 계산법을 이용하여 평가되었다.
결과: 총 1,407명 중에 138명이 인터페론감마 방출검사에서 양성으로 확인되어 본 의료기관 종사자의 잠복결핵감염 유병률은 9.82%(95% 신뢰구간 8.2–11.4)였다. 단변량 분석에서 연령(p < 0.001), 직종(p < 0.001), BCG 접종횟수(p < 0.001), 기저질환(p = 0.042), 총 근무 기간(p < 0.001), 2군 근무기간(p = 0.024), 3군 근무기간(p = 0.001), 4군 근무기간(p = 0.045)이 잠복결핵감염의 위험인자로 나타났지만 1군에서 근무한 기간은 잠복결핵감염과 유의한 연관을 보이지 않았다(p = 0.369). 다변량 분석에서 연령이 증가할수록 교차비1.081 (95%…
Advisors/Committee Members: 대학원 의학과, 201724405, 이, 선홍.
Subjects/Keywords: Latent tuberculosis infection; tuberculosis; healthcare workers; risk factor; IGRA; 의료기관종사자; 잠복결핵감염; 결핵; 인터페론감마방출검사; 위험인자
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
이, . (2019). Prevalence and Risk factors of Latent Tuberculosis Infection among Healthcare Workers. (Thesis). Ajou University. Retrieved from http://repository.ajou.ac.kr/handle/201003/17874 ; http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000028490
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
이, 선홍. “Prevalence and Risk factors of Latent Tuberculosis Infection among Healthcare Workers.” 2019. Thesis, Ajou University. Accessed January 22, 2021.
http://repository.ajou.ac.kr/handle/201003/17874 ; http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000028490.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
이, 선홍. “Prevalence and Risk factors of Latent Tuberculosis Infection among Healthcare Workers.” 2019. Web. 22 Jan 2021.
Vancouver:
이 . Prevalence and Risk factors of Latent Tuberculosis Infection among Healthcare Workers. [Internet] [Thesis]. Ajou University; 2019. [cited 2021 Jan 22].
Available from: http://repository.ajou.ac.kr/handle/201003/17874 ; http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000028490.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
이 . Prevalence and Risk factors of Latent Tuberculosis Infection among Healthcare Workers. [Thesis]. Ajou University; 2019. Available from: http://repository.ajou.ac.kr/handle/201003/17874 ; http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000028490
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Louisiana State University
13.
Chanda, Ashok Kumar.
Molecular Approaches to Detect and Control Cercospora kikuchii in Soybeans.
Degree: PhD, Plant Sciences, 2012, Louisiana State University
URL: etd-07092012-230732
;
https://digitalcommons.lsu.edu/gradschool_dissertations/3002
► Cercospora leaf blight (CLB) caused by Cercospora kikuchii, has become a troublesome disease in the southern United States. C. kikuchii produces a non-hostspecific phytotoxin and…
(more)
▼ Cercospora leaf blight (CLB) caused by Cercospora kikuchii, has become a troublesome disease in the southern United States. C. kikuchii produces a non-hostspecific phytotoxin and a pathogenicity factor known as cercosporin during infection of soybean. A quantitative real-time PCR assay was developed for detection and quantification of C. kikuchii. The sensitivity of detection is 1 pg of genomic DNA. The assay detected the presence of C. kikuchii in soybean leaves long before the appearance of disease symptoms. C. kikuchii DNA levels in soybean leaves increased slowly during early soybean development, followed by a quick increase at late reproductive stages. Results from three year field studies of soybean plants with various fungicide treatments showed that multiple fungicide applications beginning from late vegetative stages until late reproductive stages can reduce C. kikuchii growth and CLB symptom development. However, different fungicides vary in their effectiveness. In order to identify genes involved in cercosporin biosynthesis, proteins were isolated from C. kikuchii and compared between cultures grown under light (promotes toxin production up to 6 fold) and dark conditions through proteomics. Six proteins were up-regulated and two were down-regulated in C. kikuchii grown under light. Two of the up-regulated proteins [hydroxynaphthalene reductase (HNR) and adenosylhomocysteinase (AHCY)] were further studied through gene disruption. The resulting mutants showed reduced cercosporin production in vitro and virulence on soybean leaves. C. kikuchii secreted proteins from culture were also examined to identify proteins involved in the infection of soybean. Two of them showed high homology to glucan beta 1,3-glucosidase and EAP30 family proteins and identity of several proteins remains unknown. The function of these proteins in infecting soybean remains to be determined. Two small portions of AHCY gene also were inserted into a Bean Pod Mottle Virus (BPMV) derived vectors and introduced into soybean to explore the possibility of using host-induced gene silencing (HIGS) in controlling C. kikuchii infection of soybean, The target gene expression was reduced by 3.5 to 6.6-fold, and C. kikuchii growth was reduced by 16 to18-fold in the HIGS treated soybean compared to vector control plants, indicating a possible new approach to control CLB in soybean.
Subjects/Keywords: HIGS; Secreted proteins; HNR; AHCY; Latent infection; Cercosporin; Real-time PCR; CTB6; Glycine max
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APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Chanda, A. K. (2012). Molecular Approaches to Detect and Control Cercospora kikuchii in Soybeans. (Doctoral Dissertation). Louisiana State University. Retrieved from etd-07092012-230732 ; https://digitalcommons.lsu.edu/gradschool_dissertations/3002
Chicago Manual of Style (16th Edition):
Chanda, Ashok Kumar. “Molecular Approaches to Detect and Control Cercospora kikuchii in Soybeans.” 2012. Doctoral Dissertation, Louisiana State University. Accessed January 22, 2021.
etd-07092012-230732 ; https://digitalcommons.lsu.edu/gradschool_dissertations/3002.
MLA Handbook (7th Edition):
Chanda, Ashok Kumar. “Molecular Approaches to Detect and Control Cercospora kikuchii in Soybeans.” 2012. Web. 22 Jan 2021.
Vancouver:
Chanda AK. Molecular Approaches to Detect and Control Cercospora kikuchii in Soybeans. [Internet] [Doctoral dissertation]. Louisiana State University; 2012. [cited 2021 Jan 22].
Available from: etd-07092012-230732 ; https://digitalcommons.lsu.edu/gradschool_dissertations/3002.
Council of Science Editors:
Chanda AK. Molecular Approaches to Detect and Control Cercospora kikuchii in Soybeans. [Doctoral Dissertation]. Louisiana State University; 2012. Available from: etd-07092012-230732 ; https://digitalcommons.lsu.edu/gradschool_dissertations/3002

University of Georgia
14.
Ingram, Thomas William.
The genetic diversity, epidemiology, and chemical control of the causal agent of pecan anthracnose, Colletotrichum.
Degree: 2014, University of Georgia
URL: http://hdl.handle.net/10724/29857
► New genetic data shows pecan anthracnose to be caused by species within the Colletotrichum gloeosporioides species complex. Conidial germination, appressoria formation, and latent infections are…
(more)
▼ New genetic data shows pecan anthracnose to be caused by species within the Colletotrichum gloeosporioides species complex. Conidial germination, appressoria formation, and latent infections are all higher at 20 °C and 25 °C, compared to 30
°C and 35 °C. Latent infections were found in south Georgia orchards in late July 2011, and early June in 2012. Symptoms did not always develop, even when numerous latent infections were present. Field applications of strobilurins, triazoles, phosphites
and organotin combinations were effective in significantly reducing the number of foliar latent infections in 2011 and 2012. In the greenhouse the fungicides Super-Tin, Quadris Top, and ProPhyt significantly reduced the number of foliar latent infections
in pre- and post-inoculation treatments. A range of sensitivities to the triazoles, strobilurins or organotins was found in 39 isolates tested, but only 3 were completely resistant to thiophanate-methyl.
Subjects/Keywords: Colletotrichum; pecan anthracnose; organotin; triazole; strobilurin; phosphite; latent infection; fungicide sensitivity; GADPH
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Ingram, T. W. (2014). The genetic diversity, epidemiology, and chemical control of the causal agent of pecan anthracnose, Colletotrichum. (Thesis). University of Georgia. Retrieved from http://hdl.handle.net/10724/29857
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Ingram, Thomas William. “The genetic diversity, epidemiology, and chemical control of the causal agent of pecan anthracnose, Colletotrichum.” 2014. Thesis, University of Georgia. Accessed January 22, 2021.
http://hdl.handle.net/10724/29857.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Ingram, Thomas William. “The genetic diversity, epidemiology, and chemical control of the causal agent of pecan anthracnose, Colletotrichum.” 2014. Web. 22 Jan 2021.
Vancouver:
Ingram TW. The genetic diversity, epidemiology, and chemical control of the causal agent of pecan anthracnose, Colletotrichum. [Internet] [Thesis]. University of Georgia; 2014. [cited 2021 Jan 22].
Available from: http://hdl.handle.net/10724/29857.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Ingram TW. The genetic diversity, epidemiology, and chemical control of the causal agent of pecan anthracnose, Colletotrichum. [Thesis]. University of Georgia; 2014. Available from: http://hdl.handle.net/10724/29857
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Sydney
15.
Dobler, Claudia Caroline.
Towards a decision aid for treatment of latent tuberculosis infection
.
Degree: 2013, University of Sydney
URL: http://hdl.handle.net/2123/11732
► The decision to give preventive treatment to a person with latent tuberculosis infection (LTBI) is a complex one in which morbidity and mortality from potential…
(more)
▼ The decision to give preventive treatment to a person with latent tuberculosis infection (LTBI) is a complex one in which morbidity and mortality from potential progression to active tuberculosis (TB) is weighed against the morbidity and mortality associated with potential adverse effects of treatment. Without objective evidence and careful, model-based evaluation of the evidence, it is likely the risks and benefits of the two alternative strategies (treatment or no treatment) will be inaccurately assessed. It is therefore apparent that medical practitioners need assistance when making decisions about treatment of LTBI. A number of decision analyses in the past that are summarised in a systematic review in this thesis have attempted to address this issue. However, the review identified the need for a more individualised decision analysis tool. Further, the systematic review highlighted the importance of using robust estimates of key variables in any decision analysis model on LTBI treatment and it showed that the inclusion of health-related quality of life adjustments has the potential to change the decision for or against treatment of LTBI. Thus, a systematic review of quality of life in TB-related health states was conducted. A new clinical decision aid is presented that has the potential to improve physicians’ capacity to make better and more consistent decisions on treatment for LTBI by taking patients’ individual clinical characteristics into account. It showed that treatment is beneficial in the majority of scenarios for patients with evidence of LTBI. Other aspects of preventive TB treatment that were examined in this thesis include the completion rate of treatment of LTBI, the risk of developing TB among contacts of patients with TB and the prevalence of LTBI and treatment of LTBI among this group.
Subjects/Keywords: Latent tuberculosis infection;
Preventive treatment;
Decision analysis;
Tuberculosis contact tracing;
Completion of treatment
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Dobler, C. C. (2013). Towards a decision aid for treatment of latent tuberculosis infection
. (Thesis). University of Sydney. Retrieved from http://hdl.handle.net/2123/11732
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Dobler, Claudia Caroline. “Towards a decision aid for treatment of latent tuberculosis infection
.” 2013. Thesis, University of Sydney. Accessed January 22, 2021.
http://hdl.handle.net/2123/11732.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Dobler, Claudia Caroline. “Towards a decision aid for treatment of latent tuberculosis infection
.” 2013. Web. 22 Jan 2021.
Vancouver:
Dobler CC. Towards a decision aid for treatment of latent tuberculosis infection
. [Internet] [Thesis]. University of Sydney; 2013. [cited 2021 Jan 22].
Available from: http://hdl.handle.net/2123/11732.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Dobler CC. Towards a decision aid for treatment of latent tuberculosis infection
. [Thesis]. University of Sydney; 2013. Available from: http://hdl.handle.net/2123/11732
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

The Ohio State University
16.
Fluegge, Kyle.
Effects of Patient Self-Selection on Costs to Treat Latent
Tuberculosis Infection (LTBI).
Degree: PhD, Agricultural, Environmental and Developmental
Economics, 2014, The Ohio State University
URL: http://rave.ohiolink.edu/etdc/view?acc_num=osu1388665018
► The first paper uses a series of probit models to examine patient demand for isoniazid preventative therapy (9INH) for treatment of latent tuberculosis infection (LTBI)…
(more)
▼ The first paper uses a series of probit models to
examine patient demand for isoniazid preventative therapy (9INH)
for treatment of
latent tuberculosis
infection (LTBI) in an
ethnically diverse clinic population. I produce an economic model
of LTBI adherence that describes the value of immunity via acquired
(treatment with 9INH therapy) or innate (no therapeutic
intervention) means. The value of acquired versus innate immunity
to TB depends on four factors: TB contact potential,
immuno-compromised status, duration and acculturation status. This
theoretical model is tested with clinic data. Results reveal that
patients who have a greater contact potential are less likely to
complete LTBI therapy (p < 0.05), while patients with diabetes
are more likely to complete (p < 0.05). Immigration status
negatively affects completion, while acculturation positively
affects adherence (p < 0.05). The second paper uses a series of
selection models to examine the costs to treat LTBI. I use a series
of generalized Tobit models with random effects to control for
individual heterogeneity to isolate the contribution of genetic
effects to the monthly costs to treat patients who experience side
effects to 9INH. I am able to estimate the differences in 9INH
treatment costs between ethnic groups that feature distinct genetic
predispositions to suffer side effects from 9INH. Results reveal
that self-selection is present in this clinic data, although the
classic Heckman two-step estimator is inappropriate to correctly
capture this effect. I use a semi-parametric selection estimator
and compare results with the Heckman estimator. Predictive capacity
modeling shows that an ordered probit selection rule with
parametric estimator is the optimal methodology to account for
selection. The final paper uses a series of multilevel
semi-parametric selection models to examine the
comparative-effectiveness and absolute-effectiveness of isoniazid
therapy (9INH) for treatment of LTBI. The comparative models
incorporate random effects designed to control for individual
heterogeneity and semi-parametric selection estimators to isolate
the contribution of genetic effects to the total costs to treat. To
analyze absolute effectiveness, I simulate cost-effectiveness
ratios of an alternative therapy consisting of four months of
rifampin (4RIF), a drug known to cause few side effects. I compare
these ratios with bootstrapped confidence intervals of the
cost-effectiveness ratios for 9INH within each ethnic group.
Results reveal wide variations in the comparative effectiveness of
9INH across ethnic groups and biased results when the commonly
employed case deletion methodology is used. For absolute
effectiveness, 4RIF is cost-effective across all simulation
scenarios for all patient groups, except for Asians.
Advisors/Committee Members: Roe, Brian (Advisor).
Subjects/Keywords: Health Sciences; Social Research; Economics; latent tuberculosis infection, self-selection, comparative
effectiveness
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Fluegge, K. (2014). Effects of Patient Self-Selection on Costs to Treat Latent
Tuberculosis Infection (LTBI). (Doctoral Dissertation). The Ohio State University. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=osu1388665018
Chicago Manual of Style (16th Edition):
Fluegge, Kyle. “Effects of Patient Self-Selection on Costs to Treat Latent
Tuberculosis Infection (LTBI).” 2014. Doctoral Dissertation, The Ohio State University. Accessed January 22, 2021.
http://rave.ohiolink.edu/etdc/view?acc_num=osu1388665018.
MLA Handbook (7th Edition):
Fluegge, Kyle. “Effects of Patient Self-Selection on Costs to Treat Latent
Tuberculosis Infection (LTBI).” 2014. Web. 22 Jan 2021.
Vancouver:
Fluegge K. Effects of Patient Self-Selection on Costs to Treat Latent
Tuberculosis Infection (LTBI). [Internet] [Doctoral dissertation]. The Ohio State University; 2014. [cited 2021 Jan 22].
Available from: http://rave.ohiolink.edu/etdc/view?acc_num=osu1388665018.
Council of Science Editors:
Fluegge K. Effects of Patient Self-Selection on Costs to Treat Latent
Tuberculosis Infection (LTBI). [Doctoral Dissertation]. The Ohio State University; 2014. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=osu1388665018

Indian Institute of Science
17.
Baloni, Priyanka.
A Systems Biology Approach towards Understanding Host Response and Pathogen Adaptation in Latent Tuberculosis Infection.
Degree: PhD, Faculty of Science, 2018, Indian Institute of Science
URL: http://etd.iisc.ac.in/handle/2005/2967
► Mycobacterium tuberculosis, the etiological agent of tuberculosis, has adapted with the host environment and evolved to survive in harsh conditions in the host. The pathogen…
(more)
▼ Mycobacterium tuberculosis, the etiological agent of tuberculosis, has adapted with the host environment and evolved to survive in harsh conditions in the host. The pathogen has successfully evolved strategies not only to evade the host immune system but also to thrive within the host cells. Upon
infection, the pathogen is either cleared due to the host immune response, or it survives and causes active tuberculosis (TB)
infection. In a number of cases however, the pathogen is neither killed nor does it actively proliferate, but it remains dormant in the host until the environment becomes favorable. This dormant state of pathogen is responsible for
latent TB
infection (LTBI). WHO reports indicated that as much as a third of the whole world’s population is exposed to the pathogen, of which a significant proportion could be latently infected (WHO report, 2015). These individuals do not show symptoms of active TB
infection and hence are difficult to detect. The
latent TB infected (LTBI) individuals serve as a reservoir for the pathogen, which can lead to epidemics when the conditions change. Hence, it is necessary to understand the host -pathogen interactions during LTBI, as this might provide clues to developing new strategies to detect and curb a
latent infection.
Host-pathogen interactions are multifaceted, in which both species attempt to recognize and respond to each other, all of these through specific molecules making distinct interactions with the other species. The outcome of the
infection is thus decided by a complex set of host-pathogen interactions. The complexity arises since a large number of molecular components are involved, also multiplicity of interactions among these components and due to several feedback, feed forwards or other regulatory or influential loops within the system. The complexity of biological systems makes modeling and simulation an essential and critical part of systems– level studies. Systems biology studies provide an integrated framework to analyze and understand the function of biological systems.
This work addresses some of these issues with an unbiased systems-level analysis so as to identify and understand the important global changes both in the host and in the pathogen during LTBI. The broad objectives of the work was to identify the key processes that vary in the host during
latent infection, the set of metabolic reactions in the host which can be modulated to control the reactivation of
infection, global adaptation in Mycobacterium tuberculosis (Mtb) and then to utilize this knowledge to identify strategies for tackling
latent infection. A review of literature of the current understanding of latency from the pathogen and the host perspective is described in chapter 1. From this, it is clear that most available studies have focused on the role of individual molecules and individual biological processes such as granuloma formation, toll-like receptor signaling, T cell responses as well as cytokine signaling, in either initiating or maintaining a
latent infection, but there…
Advisors/Committee Members: Chandra, Nagasuma (advisor).
Subjects/Keywords: Mycobacterium Tuberculosis; Systems Biology; Latent Tuberculosis Infection (LTBI); Tuberculosis; Tuberculosis Pathogenesis; Tuberculosis Infection-Host Immune Response; Tuberculosis Vaccines; Antitubercular Agents; Mtb; Mycobacterium smegmatis; Genome-scale Metabolic Model (GSM); Latent TB Infection; Molecular Biophysics
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Baloni, P. (2018). A Systems Biology Approach towards Understanding Host Response and Pathogen Adaptation in Latent Tuberculosis Infection. (Doctoral Dissertation). Indian Institute of Science. Retrieved from http://etd.iisc.ac.in/handle/2005/2967
Chicago Manual of Style (16th Edition):
Baloni, Priyanka. “A Systems Biology Approach towards Understanding Host Response and Pathogen Adaptation in Latent Tuberculosis Infection.” 2018. Doctoral Dissertation, Indian Institute of Science. Accessed January 22, 2021.
http://etd.iisc.ac.in/handle/2005/2967.
MLA Handbook (7th Edition):
Baloni, Priyanka. “A Systems Biology Approach towards Understanding Host Response and Pathogen Adaptation in Latent Tuberculosis Infection.” 2018. Web. 22 Jan 2021.
Vancouver:
Baloni P. A Systems Biology Approach towards Understanding Host Response and Pathogen Adaptation in Latent Tuberculosis Infection. [Internet] [Doctoral dissertation]. Indian Institute of Science; 2018. [cited 2021 Jan 22].
Available from: http://etd.iisc.ac.in/handle/2005/2967.
Council of Science Editors:
Baloni P. A Systems Biology Approach towards Understanding Host Response and Pathogen Adaptation in Latent Tuberculosis Infection. [Doctoral Dissertation]. Indian Institute of Science; 2018. Available from: http://etd.iisc.ac.in/handle/2005/2967
18.
Γερακάρη, Στυλιανή.
Η επίδραση της συλλοίμωξης από ηπατοτρόπους και ηπατιτιδομιμητικούς ιούς στη φυσική εξέλιξη της χρόνια HBV και HCV ηπατοπάθειας.
Degree: 2012, National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ)
URL: http://hdl.handle.net/10442/hedi/29986
► Occult HBV infection (HBV) in patients with chronic hepatitis C (HCV) has been reported to be clinically significant and contribute to chronic liver damage, including…
(more)
▼ Occult HBV infection (HBV) in patients with chronic hepatitis C (HCV) has been reported to be clinically significant and contribute to chronic liver damage, including cirrhosis and hepatocellular carcinoma (HCC) and may be associated with worse response tο antiviral treatment. Hepatomimetic viruses, such as CMV and EBV may influence the severity of liver disease and treatment response in HCV and HBV-infected patients. The aim of this study was to evaluate the possible impact of occult HBV infection on clinical outcome of liver disease and the response to combination treatment in chronic HCV patients as well as to reveal the clinical significance of latent CMV and /or EBV infection in the progression of liver disease and the response to treatment in HCV and HBV patients. Seventy-five HBsAg negative patients with HCV infection confirmed by RT-PCR RNA and liver biopsy were evaluated. Serological assays of antiHBc and antiHBs were performed. Serum HBV DNA was evaluated using COBAS AMPLICOR HBV Monitor assay (cut off: 200 copies /ml). The values of AST, ALT, γGT, albumin, PLTs were determined. HCV genotypes were identified according to the Simmods et al. criteria. Titers of anti-CMV IgG and anti-VCA IgG were eveluated to assess “silent” infection of CMV and EBV by ELFA and ELISA, respectively. All of them had received combination therapy with peg-interferon-a plus ribavirin. The presence of HBV-DNA was correlated with epidemiological, clinical, laboratory data, HCV genotype, serological markers of HBV infection and response to the above mentioned combination therapy for HCV patients. Serum HBV DNA was detected in 33 (44.00%) HCV patients with mean:3152 IU/ml and range:260-8970 IU/ml. The prevalence of occult HBV infection was particularly high among anti-HBc (64.51%) or antiHBc plus anti-HBs positive (45.83%) patients. Occult HBV infection was also detected in 2 (10.00 %) patients negative for all HBV serum markers, although the HBV DNA titer was particularly low (<700 IU/ml). We observed that HCV patients with occult HBV infection had higher aminotransferases and γGT than patients without HBV DNA. The prevalence of occult HBV infection was in parallel with the severity of chronic liver disease. There was no significant difference in gender, age and genotype distribution in relation to the presence or absence of occult HBV infection and the response to treatment. In addition, the prevalence of latent CMV and EBV infection paralleled the severity of liver disease of HCV and HBV patients. It was higher among patients with cirrhosis and HCC, and lower among patients with normal aminotransferases. However, the difference was not statistically significant. Although the relation between genotype and treatment response is well-defined, our study revealed that other factors, such as latent HBV, CMV and/or EBV latent infection contribute to the treatment response of HCV patients. Moreover, we evaluated 30 HBV patients for occult infection with CMV and/or EBV in order to assess the possible role of occult infection. Νo…
Subjects/Keywords: Συλλοιμώξεις ιών; Λανθάνουσα HBV λοίμωξη; Λανθάνουσα CMV λοίμωξη; Λανθάνουσα EBV λοίμωξη; Επιπολασμός συλλοιμώξεων; Επίδραση συλλοιμώξεων στην ανταπόκριση στην HCV / HBV αντιική αγωγή; Viral coinfections; Occult HBV infection; Latent CMV infection; Latent EBV infection; Epidemiology of coinfections; The effect of coinfections in treatment response of HCV / HBV patients
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Γερακάρη, . . (2012). Η επίδραση της συλλοίμωξης από ηπατοτρόπους και ηπατιτιδομιμητικούς ιούς στη φυσική εξέλιξη της χρόνια HBV και HCV ηπατοπάθειας. (Thesis). National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ). Retrieved from http://hdl.handle.net/10442/hedi/29986
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Γερακάρη, Στυλιανή. “Η επίδραση της συλλοίμωξης από ηπατοτρόπους και ηπατιτιδομιμητικούς ιούς στη φυσική εξέλιξη της χρόνια HBV και HCV ηπατοπάθειας.” 2012. Thesis, National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ). Accessed January 22, 2021.
http://hdl.handle.net/10442/hedi/29986.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Γερακάρη, Στυλιανή. “Η επίδραση της συλλοίμωξης από ηπατοτρόπους και ηπατιτιδομιμητικούς ιούς στη φυσική εξέλιξη της χρόνια HBV και HCV ηπατοπάθειας.” 2012. Web. 22 Jan 2021.
Vancouver:
Γερακάρη . Η επίδραση της συλλοίμωξης από ηπατοτρόπους και ηπατιτιδομιμητικούς ιούς στη φυσική εξέλιξη της χρόνια HBV και HCV ηπατοπάθειας. [Internet] [Thesis]. National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ); 2012. [cited 2021 Jan 22].
Available from: http://hdl.handle.net/10442/hedi/29986.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Γερακάρη . Η επίδραση της συλλοίμωξης από ηπατοτρόπους και ηπατιτιδομιμητικούς ιούς στη φυσική εξέλιξη της χρόνια HBV και HCV ηπατοπάθειας. [Thesis]. National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ); 2012. Available from: http://hdl.handle.net/10442/hedi/29986
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
19.
Hall, Ingela.
Prevalens och uppföljning av latent tuberkulos bland migranter i Region Jönköpings Län.
Degree: Health and Education, 2018, University of Skövde
URL: http://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-16637
► Introduktion: Tuberkulos är en av världens mest spridda infektionssjukdomar. En tredjedel av jordens befolkning beräknas bära på bakterien utan att vara sjuka (latent tuberkulos,…
(more)
▼ Introduktion: Tuberkulos är en av världens mest spridda infektionssjukdomar. En tredjedel av jordens befolkning beräknas bära på bakterien utan att vara sjuka (latent tuberkulos, LTBI). Närmare tio procent av bärarna utvecklar aktiv tuberkulos någon gång under livet. Europa har jämförelsevis låg incidens av tuberkulos och i Sverige har antalet tuberkulosfall minskat sedan mitten av 40-talet. I Sverige ses de senaste årens ökade antal migranter som en förklaring till en tillfälligt ökad prevalens av tuberkulos. Tidig diagnostik och behandling av tuberkulos är avgörande faktorer för att förhindra smittspridning och ger den enskilde individen möjlighet att hantera sin hälsa, vilket är angeläget ur ett folkhälsoperspektiv. Landstingen/regionerna har valt olika strategier för vilka som ska inkluderas i screening för tuberkulos vid hälsoundersökningar av migranter. Syfte: Syftet med studien var att undersöka prevalens och uppföljning av latent tuberkulos bland migranter som genomgått hälsoundersökning vid vårdcentraler i Region Jönköpings län. Metod: Studien var en retrospektiv observationsstudie utifrån kvantitativ ansats. Data samlades in genom journalgranskning och 361 journaler inkluderades i analyserna. Förekomst av latent och aktiv tuberkulos korrelerades med kön, ålder och ursprungsland. Resultat: Resultaten från studien visade att prevalensen av LTBI i studiepopulationen var 9.4 %. Resultaten visade att LTBI var vanligare hos män och individer > 35 år. Däremot sågs inga skillnader utifrån ursprungsland. Slutsats: Studien är av begränsad storlek och därmed generaliserbarhet. LTBI är relativt vanligt bland migranter. Ytterligare studier behövs för att identifiera optimala rutiner för screening och förebyggande insatser i migrantgruppen.
Introduction: Tuberculosis is one of the world's most widespread infectious diseases. One third of the world’s population is expected to carry the bacterium without being ill (latent tuberculosis, LTBI). Nearly ten percent of the carriers develop active tuberculosis sometime during their lifetime. Europe has a comparatively low incidence of tuberculosis and in Sweden the number of cases of tuberculosis has decreased since the mid-40s. In Sweden, the increased number of immigrants in recent years is seen as an explanation for a temporarily increased prevalence of tuberculosis. Early diagnosis and treatment of tuberculosis are key factors in preventing the spread of infection and giving the individual the opportunity to manage their health, which is important from a public health perspective. The county councils/regions have chosen different strategies for whom to be included in screening for tuberculosis in health surveys of immigrants. Aim: The aim of the study was to investigate the prevalence and follow-up of latent tuberculosis among immigrants who have undergone a health examination at health centers in the County of Jönköping. Method: The study was a retrospective observation study based on quantitative approach. Data was…
Subjects/Keywords: age; infection disease; latent tuberculosis; immigrant; risk country; infektionssjukdom; latent tuberkulos; migrant; riskland; ålder; Public Health, Global Health, Social Medicine and Epidemiology; Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi
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MLA ·
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APA (6th Edition):
Hall, I. (2018). Prevalens och uppföljning av latent tuberkulos bland migranter i Region Jönköpings Län. (Thesis). University of Skövde. Retrieved from http://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-16637
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Hall, Ingela. “Prevalens och uppföljning av latent tuberkulos bland migranter i Region Jönköpings Län.” 2018. Thesis, University of Skövde. Accessed January 22, 2021.
http://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-16637.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Hall, Ingela. “Prevalens och uppföljning av latent tuberkulos bland migranter i Region Jönköpings Län.” 2018. Web. 22 Jan 2021.
Vancouver:
Hall I. Prevalens och uppföljning av latent tuberkulos bland migranter i Region Jönköpings Län. [Internet] [Thesis]. University of Skövde; 2018. [cited 2021 Jan 22].
Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-16637.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Hall I. Prevalens och uppföljning av latent tuberkulos bland migranter i Region Jönköpings Län. [Thesis]. University of Skövde; 2018. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-16637
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Georgia
20.
Kakaire, Robert.
Risk for latent tuberculosis infection among household and non-household contacts of TB cases in an urban African setting.
Degree: 2018, University of Georgia
URL: http://hdl.handle.net/10724/38395
► Statement of the Problem: Tuberculosis remains a major global public health problem. About 25 percent of the world’s population is infected with Mycobacterium tuberculosis (M.…
(more)
▼ Statement of the Problem: Tuberculosis remains a major global public health problem. About 25 percent of the world’s population is infected with Mycobacterium tuberculosis (M. tuberculosis). Although individuals with latent tuberculosis are
not infectious, they are at risk of developing active disease and becoming the next pool of infectious individuals. Studies show that risk for progression to disease once infected may range from 5% in children who are recently exposed to as high as 16%
among individuals infected with the human immunodeficiency virus. Purpose: To identify individuals in the community who are latently infected with tuberculosis. Methods: We conducted two inter-related studies; Study 1 was to examine the effect of
household and non-household exposure to an infectious tuberculosis case on the prevalence of latent tuberculosis infection in the community. We identified index TB cases and matched them with controls who in turn enumerated their social contacts who were
then approached and asked to participate in the study. Diagnosis of latent tuberculosis infection was by tuberculin skin test. The second was an incident cohort study to investigate whether differences in the prevalence of latent tuberculosis infection
between men and women observed in previous studies could be due to differences in the incidence of latent tuberculosis infection. A cohort of tuberculin skin test negative individuals was enrolled between 2014 and 2016 and were followed -up and a repeat
TST was placed to determine tuberculin skin test conversion. Main results: Infection was highest among household case contacts and lowest in household contacts of controls. Prevalent infection among non-household case contacts was similar to that of
non-household control contacts. The incidence study found that men had a higher risk for infection than women. Fifty-one percent of converters were men representing an incidence rate of 16.2 per 100PYO while 48.4% of the converters were women
representing an incidence rate of 10.6 per 100PYO among women.
Subjects/Keywords: Prevalence; Latent tuberculosis infection; Household and Non-household; Index TB cases; Controls; Social contacts; Incidence rate; Converter; Men; Women
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APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Kakaire, R. (2018). Risk for latent tuberculosis infection among household and non-household contacts of TB cases in an urban African setting. (Thesis). University of Georgia. Retrieved from http://hdl.handle.net/10724/38395
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Kakaire, Robert. “Risk for latent tuberculosis infection among household and non-household contacts of TB cases in an urban African setting.” 2018. Thesis, University of Georgia. Accessed January 22, 2021.
http://hdl.handle.net/10724/38395.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Kakaire, Robert. “Risk for latent tuberculosis infection among household and non-household contacts of TB cases in an urban African setting.” 2018. Web. 22 Jan 2021.
Vancouver:
Kakaire R. Risk for latent tuberculosis infection among household and non-household contacts of TB cases in an urban African setting. [Internet] [Thesis]. University of Georgia; 2018. [cited 2021 Jan 22].
Available from: http://hdl.handle.net/10724/38395.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Kakaire R. Risk for latent tuberculosis infection among household and non-household contacts of TB cases in an urban African setting. [Thesis]. University of Georgia; 2018. Available from: http://hdl.handle.net/10724/38395
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Florida
21.
Chapman, Helena Jeanne.
Adherence to Tuberculosis Infection Control Measures: Addressing the "Knowledge-Action" Gap among Healthcare Workers in the Dominican Republic.
Degree: PhD, Public Health - Environmental and Global Health, 2016, University of Florida
URL: https://ufdc.ufl.edu/UFE0050628
Subjects/Keywords: control; dominican; healthcare; infection; latent; powerlessness; republic; tuberculosis; workers
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Chapman, H. J. (2016). Adherence to Tuberculosis Infection Control Measures: Addressing the "Knowledge-Action" Gap among Healthcare Workers in the Dominican Republic. (Doctoral Dissertation). University of Florida. Retrieved from https://ufdc.ufl.edu/UFE0050628
Chicago Manual of Style (16th Edition):
Chapman, Helena Jeanne. “Adherence to Tuberculosis Infection Control Measures: Addressing the "Knowledge-Action" Gap among Healthcare Workers in the Dominican Republic.” 2016. Doctoral Dissertation, University of Florida. Accessed January 22, 2021.
https://ufdc.ufl.edu/UFE0050628.
MLA Handbook (7th Edition):
Chapman, Helena Jeanne. “Adherence to Tuberculosis Infection Control Measures: Addressing the "Knowledge-Action" Gap among Healthcare Workers in the Dominican Republic.” 2016. Web. 22 Jan 2021.
Vancouver:
Chapman HJ. Adherence to Tuberculosis Infection Control Measures: Addressing the "Knowledge-Action" Gap among Healthcare Workers in the Dominican Republic. [Internet] [Doctoral dissertation]. University of Florida; 2016. [cited 2021 Jan 22].
Available from: https://ufdc.ufl.edu/UFE0050628.
Council of Science Editors:
Chapman HJ. Adherence to Tuberculosis Infection Control Measures: Addressing the "Knowledge-Action" Gap among Healthcare Workers in the Dominican Republic. [Doctoral Dissertation]. University of Florida; 2016. Available from: https://ufdc.ufl.edu/UFE0050628

University of Otago
22.
Apriani, Lika.
Infection control and latent tuberculosis infection in health care workers in Indonesia
.
Degree: University of Otago
URL: http://hdl.handle.net/10523/9717
► Background: Health care workers (HCWs) and health care students (HCSs), especially in low and middle-income countries (LMICs) are particularly vulnerable to being infected with Mycobacterium…
(more)
▼ Background: Health care workers (HCWs) and health care students (HCSs), especially in low and middle-income countries (LMICs) are particularly vulnerable to being infected with Mycobacterium tuberculosis. The extent of
latent TB
infection (LTBI) among HCWs and HCSs in LMICs, and in Indonesia, is currently unknown, as is the degree of implementation of
infection control measures in Indonesian health settings.
Objective: This thesis aimed to: 1) describe the prevalence and incidence of LTBI in HCWs in LMICs and to identify associated risk factors, 2) assess the implementation of TB
infection control measures in primary health centres (PHCs) in Bandung, Indonesia, 3) estimate the prevalence of LTBI measured by tuberculin skin test (TST) and identify factors associated with LTBI in HCWs in a tertiary referral hospital, and 4) estimate the prevalence of LTBI by interferon-gamma release assays (IGRA) and TST, the one-year test conversion rates, and identify associated risk factors in HCSs.
Methods and results: In a systematic review of 85 studies published from 2005 to 2017 the prevalence of LTBI in HCWs using TST ranged from 8-98% (mean 49%), and for HCSs from 1-74% (mean 32%). Using IGRA, the prevalence in HCWs ranged from 9-86% (mean 39%), and in HCSs from 10-44% (mean 24%). HCWs from countries with an annual TB incidence of >300/100,000 had the highest prevalence of test positivity. The annual incidence of LTBI ranged from 1-38% (mean 17%) in HCWs, and 3-8% (mean 5%) in HCSs, when estimated from serial TST, and from 10-30% (mean 18%) and 8% (one study), when estimated with IGRA in HCWs and HCSs respectively. Occupational factors associated with LTBI in HCWs were those that involved more direct contact with a TB patient or prolonged exposure. Only 15 studies reported any TB
infection control measures.
A cross sectional study assessing the implementation of TB
infection control practices was conducted in 24 selected PHCs in Bandung, Indonesia. The evaluation of four key areas showed that TB
infection control measures were generally not implemented. The median number of TB
infection control measures implemented was 21 of 41 assessed. PHCs with laboratory facilities and high TB case numbers were more likely to implement TB
infection control measures compared to other PHCs.
A cross-sectional study examining the prevalence of LTBI measured by TST was conducted in 395 HCWs working in one public tertiary referral hospital in Bandung. The prevalence of positive TST was 75.1% (95% confidence interval 69.4-80.0%). The risk of TST positivity increased with increasing work years and was high across the hospital, suggesting that hospital wide measures are needed to counter the risk.
A cohort study was conducted in HCSs entering their clinical training programme. At baseline, the prevalence of a positive IGRA was 18.5% (n=379), and of a positive TST was 32.7% (n=272). At one-year follow up, the risk of M. tuberculosis
infection according to IGRA conversion was 8.9% (n=293) and according to TST was 35.4% (n=180). Discordance…
Advisors/Committee Members: Hill, Philip (advisor).
Subjects/Keywords: Tuberculosis;
Infection control;
latent tuberculosis infection;
health care worker;
health care student;
Indonesia
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Apriani, L. (n.d.). Infection control and latent tuberculosis infection in health care workers in Indonesia
. (Doctoral Dissertation). University of Otago. Retrieved from http://hdl.handle.net/10523/9717
Note: this citation may be lacking information needed for this citation format:
No year of publication.
Chicago Manual of Style (16th Edition):
Apriani, Lika. “Infection control and latent tuberculosis infection in health care workers in Indonesia
.” Doctoral Dissertation, University of Otago. Accessed January 22, 2021.
http://hdl.handle.net/10523/9717.
Note: this citation may be lacking information needed for this citation format:
No year of publication.
MLA Handbook (7th Edition):
Apriani, Lika. “Infection control and latent tuberculosis infection in health care workers in Indonesia
.” Web. 22 Jan 2021.
Note: this citation may be lacking information needed for this citation format:
No year of publication.
Vancouver:
Apriani L. Infection control and latent tuberculosis infection in health care workers in Indonesia
. [Internet] [Doctoral dissertation]. University of Otago; [cited 2021 Jan 22].
Available from: http://hdl.handle.net/10523/9717.
Note: this citation may be lacking information needed for this citation format:
No year of publication.
Council of Science Editors:
Apriani L. Infection control and latent tuberculosis infection in health care workers in Indonesia
. [Doctoral Dissertation]. University of Otago; Available from: http://hdl.handle.net/10523/9717
Note: this citation may be lacking information needed for this citation format:
No year of publication.

Universidade Federal de Santa Maria
23.
Sandra Vanderli Mayer-Winkelmann.
DISTRIBUIÇÃO DO DNA DOS HERPESVÍRUS BOVINO TIPOS 1 (BHV-1) E 5 (BHV-5) NO ENCÉFALO DE COELHOS DURANTE A INFECÇÃO LATENTE.
Degree: 2005, Universidade Federal de Santa Maria
URL: http://coralx.ufsm.br/tede/tde_busca/arquivo.php?codArquivo=1550
► O herpesvírus bovino tipo 5 (BHV-5) é um importante agente etiológico de meningoencefalite em bovinos e estabelece infecção latente em seus hospedeiros, principalmente nos gânglios…
(more)
▼ O herpesvírus bovino tipo 5 (BHV-5) é um importante agente etiológico de meningoencefalite em bovinos e estabelece infecção latente em seus hospedeiros, principalmente nos gânglios dos nervos sensoriais. No entanto, a colonização de áreas profundas do cérebro com DNA viral pode ter implicações importantes na patogenia da infecção pelo BHV-5 após a reativação da infecção latente. Neste estudo, foi investigada a distribuição do DNA do BHV-5 no cérebro de coelhos infectados experimentalmente, antes e após a reativação da infecção latente, utilizando um nested-PCR para uma seqüência do gene da glicoproteína B. Dezoito coelhos infectados pela via intranasal com um isolado brasileiro de BHV-5 foram divididos em dois grupos: coelhos do grupo A (n=8) foram submetidos a eutanásia 60 dias pós inoculação (pi) para a coleta de tecidos; animais do grupo B (n=7) foram submetidos a administração de dexametasona no dia 60 pi. Para comparação foram utilizados dois grupos de coelhos inoculados com o BHV-1 (C, n=3 e D, n=3), cada grupo sendo submetido a um dos tratamentos acima, respectivamente. Nos animais do grupo A, o DNA viral foi consistentemente detectado no gânglio trigêmeo (8/8), freqüentemente no cerebelo (6/8), com menor freqüência na ponte e córtex anterior (3/8) e ocasionalmente no tálamo (2/8) e córtices ventro-lateral, dorso-lateral e posterior, pedúnculo cerebral e tálamo (1/8). Nos animais previamente submetidos à reativação, a distribuição do DNA viral foi mais ampla, sendo detectado mais consistentemente, além do TG (7/7), nos córtices ventro-lateral (6/7), e posterior (5/7), ponte e tálamo (4/7) e menos freqüentemente no pedúnculo cerebral (3/7). Em contrapartida, os animais inoculados com o BHV-1 apresentaram o DNA viral latente em poucos tecidos além do TG, e não apresentaram alterações importantes na distribuição do DNA viral após a reativação. Esses resultados demonstraram que o DNA latente do BHV-5 - e não o do BHV-1 - pode estar presente em várias áreas do cérebro de coelhos infectados experimentalmente. A reativação induzida por dexametasona resulta na reativação viral e provavelmente na colonização de áreas adicionais no cérebro. Com base nesses resultados pode-se especular que a reativação do DNA viral latente nestas regiões pode contribuir para a recrudescência de doença neurológica observada após a reativação da infecção latente pelo BHV-5.
Bovine herpesvirus type 5 (BHV-5) is a major etiologic agent of meningo-encephalitis in cattle and establishes lifelong latent infection in trigeminal ganglia and also in other areas of the brain. Colonization of deep areas of the brain with latent viral DNA may have important implications on the pathogenesis of BHV-5 neurological infection upon reactivation. In this study, we investigated the distribution of BHV-5 DNA in the brain of experimentally infected rabbits a laboratory model for BHV-5 infection - prior and subsequently to virus reactivation, using a nested PCR for the glycoprotein B gene. Eighteen rabbits inoculated intranasally with a Brazilian BHV-5…
Advisors/Committee Members: Eduardo Furtado Flores, Luizinho Caron, Luciane Teresinha Lovato.
Subjects/Keywords: herpesvírus bovino tipos 1 e 5; BHV-5; BHV-1; infecção latente; coelhos; MEDICINA VETERINARIA; bovine herpesvirus type 5; BHV-5; BHV-1; latent infection; rabbits
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Mayer-Winkelmann, S. V. (2005). DISTRIBUIÇÃO DO DNA DOS HERPESVÍRUS BOVINO TIPOS 1 (BHV-1) E 5 (BHV-5) NO ENCÉFALO DE COELHOS DURANTE A INFECÇÃO LATENTE. (Thesis). Universidade Federal de Santa Maria. Retrieved from http://coralx.ufsm.br/tede/tde_busca/arquivo.php?codArquivo=1550
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Mayer-Winkelmann, Sandra Vanderli. “DISTRIBUIÇÃO DO DNA DOS HERPESVÍRUS BOVINO TIPOS 1 (BHV-1) E 5 (BHV-5) NO ENCÉFALO DE COELHOS DURANTE A INFECÇÃO LATENTE.” 2005. Thesis, Universidade Federal de Santa Maria. Accessed January 22, 2021.
http://coralx.ufsm.br/tede/tde_busca/arquivo.php?codArquivo=1550.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Mayer-Winkelmann, Sandra Vanderli. “DISTRIBUIÇÃO DO DNA DOS HERPESVÍRUS BOVINO TIPOS 1 (BHV-1) E 5 (BHV-5) NO ENCÉFALO DE COELHOS DURANTE A INFECÇÃO LATENTE.” 2005. Web. 22 Jan 2021.
Vancouver:
Mayer-Winkelmann SV. DISTRIBUIÇÃO DO DNA DOS HERPESVÍRUS BOVINO TIPOS 1 (BHV-1) E 5 (BHV-5) NO ENCÉFALO DE COELHOS DURANTE A INFECÇÃO LATENTE. [Internet] [Thesis]. Universidade Federal de Santa Maria; 2005. [cited 2021 Jan 22].
Available from: http://coralx.ufsm.br/tede/tde_busca/arquivo.php?codArquivo=1550.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Mayer-Winkelmann SV. DISTRIBUIÇÃO DO DNA DOS HERPESVÍRUS BOVINO TIPOS 1 (BHV-1) E 5 (BHV-5) NO ENCÉFALO DE COELHOS DURANTE A INFECÇÃO LATENTE. [Thesis]. Universidade Federal de Santa Maria; 2005. Available from: http://coralx.ufsm.br/tede/tde_busca/arquivo.php?codArquivo=1550
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
24.
Thaísa Reis dos Santos.
Detecção molecular do herpesvírus canino tipo-1 em cadelas com histórico de desordens reprodutivas no sudeste do brasil.
Degree: 2014, Federal University of Uberlândia
URL: http://www.bdtd.ufu.br//tde_busca/arquivo.php?codArquivo=5437
► O Herpesvírus canino tipo 1 (CaHV-1) está associado a desordens reprodutivas e mortalidade neonatal, podendo ser encontrado em cães saudáveis assintomáticos ou associado a manifestações…
(more)
▼ O Herpesvírus canino tipo 1 (CaHV-1) está associado a desordens reprodutivas e mortalidade neonatal, podendo ser encontrado em cães saudáveis assintomáticos ou associado a manifestações clínicas variadas como lesões vesiculares genitais, infecções oculares e doença respiratória. O objetivo deste estudo foi detectar a presença do CaHV-1, através da reação em cadeia de polimerase (PRC), em amostras de urina e em swab ocular e vaginal de cadelas na cidade de Uberlândia, Minas Gerais, Brasil. Foram utilizadas 20 cadelas com histórico ou sinais de desordens reprodutivas. Dois animais apresentaram resultado positivo na PCR (10%) nas amostras de urina e secreção ocular, respectivamente, um diagnosticado com piometra e outro saudável e histórico de natimortalidade. Todas as amostras de secreção vaginal foram negativas. No sequenciamento de DNA as amostras positivas apresentaram 100% de similaridade de nucleotídeos com outras quatro cepas de CaHV-1 já descritas e depositadas no Genbank. Os cães positivos na PCR no presente estudo provavelmente eram portadores de infecção latente. A detecção do DNA viral nas amostras avaliadas confirma a presença do CaHV-1 na população canina do município de Uberlândia. Trata-se da primeira detecção molecular do agente na região sudeste do Brasil.
Canine herpesvirus-1 (CaHV-1) is known to cause reproductive disorders and fatal infections in puppies, and may also be found in asymptomatic dogs or related to vaginal vesicular lesions, ocular infections and respiratory diseases. The aim of this study was investigate the ocurrence of CaHV-1 using the polymerase chain reaction (PCR) within urine samples, ocular and vaginal swab samples from Uberlândia, MG, Brazil. Twenty mature bitches, with at least one estrous and reproductive disorders history and/or symptoms were used. Two out of twenty dogs (10%) were positive in the urine and ocular swab samples, respectively, one with pyometra diagnosis and another one healthy with history of stillbirth. No positive results were detected within vaginal swab samples. Sequence analysis of the DNA polymerase gene of the positive samples indicated 100% identity with the sequence of the four CaHV-1 strains selected from Genbank. These findings suggest that positive dogs might be CaHV-1 latent carriers. Additionally, the results confirm the presence of CaHV-1 circulating within urban canine population of Uberlândia, MG. This is the first report that a CaHV-1 infection has been detected in the Southeast Brazil.
Advisors/Committee Members: Anna Monteiro Correia Lima Ribeiro, Alessandra Aparecida Medeiros, Joely Ferreira Figueiredo Bittar, Selwyn Arlington Headley.
Subjects/Keywords: Herpesvírus canino; Infecção latente; Reação em cadeia de polimerase; Doenças reprodutivas; MEDICINA VETERINARIA; Veterinária; Cão - Doenças; Canine Herpesvirus; Latent infection; Polymerase chain reaction; Reproduction diseases
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Santos, T. R. d. (2014). Detecção molecular do herpesvírus canino tipo-1 em cadelas com histórico de desordens reprodutivas no sudeste do brasil. (Thesis). Federal University of Uberlândia. Retrieved from http://www.bdtd.ufu.br//tde_busca/arquivo.php?codArquivo=5437
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Santos, Thaísa Reis dos. “Detecção molecular do herpesvírus canino tipo-1 em cadelas com histórico de desordens reprodutivas no sudeste do brasil.” 2014. Thesis, Federal University of Uberlândia. Accessed January 22, 2021.
http://www.bdtd.ufu.br//tde_busca/arquivo.php?codArquivo=5437.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Santos, Thaísa Reis dos. “Detecção molecular do herpesvírus canino tipo-1 em cadelas com histórico de desordens reprodutivas no sudeste do brasil.” 2014. Web. 22 Jan 2021.
Vancouver:
Santos TRd. Detecção molecular do herpesvírus canino tipo-1 em cadelas com histórico de desordens reprodutivas no sudeste do brasil. [Internet] [Thesis]. Federal University of Uberlândia; 2014. [cited 2021 Jan 22].
Available from: http://www.bdtd.ufu.br//tde_busca/arquivo.php?codArquivo=5437.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Santos TRd. Detecção molecular do herpesvírus canino tipo-1 em cadelas com histórico de desordens reprodutivas no sudeste do brasil. [Thesis]. Federal University of Uberlândia; 2014. Available from: http://www.bdtd.ufu.br//tde_busca/arquivo.php?codArquivo=5437
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Indian Institute of Science
25.
Deka, Geeta.
Structural and Functional Studies on Pyridoxal Kinase and Pyridoxal 5′-phosphate Dependent Enzymes.
Degree: PhD, Faculty of Science, 2018, Indian Institute of Science
URL: http://etd.iisc.ac.in/handle/2005/3779
► Most of the chemical reactions of living cells are catalyzed by protein enzymes. These enzymes are very efficient and display a high degree of specificity…
(more)
▼ Most of the chemical reactions of living cells are catalyzed by protein enzymes. These enzymes are very efficient and display a high degree of specificity with respect to the reaction catalyzed. Cellular activities depend critically on the precise three-dimensional structure and function of thousands of enzymes. Many enzymes require binding of metal ions or small organic molecules for their function. The organic molecules that are indispensible components of catalysis by proteins are called coenzymes. Pyridoxal 5ʹ-phosphate (PLP) is a versatile coenzyme found in all living cells. PLP-dependent enzymes play a key role in the function of most of the enzymes catalyzing reactions in the metabolic pathways of amino acid synthesis and degradation. The enzyme pyridoxal kinase serves to make available the co-enzyme PLP to apo-PLP dependent enzymes. Because of their key role in cellular function and their medical importance, the structure and function of PLP-dependent enzymes have been extensively investigated. In the past decade, detailed investigations on the structure and function of several PLP-dependent enzymes have been carried out in our laboratory. The enzymes studied are B. subtilis serinehydroxymethyl transferase (SHMT), S. typhimurium acetylornithine aminotransferase (AcOAT), S. typhimurium and E. coli diaminopropionate ammonia lyase (DAPAL), S. typhimurium D-serine dehydratase (DSD), S. typhimurium D-cysteine desulfhydrase (DCyD) and S. typhimurium arginine decarboxylase (ArgD).
The extensive studies conducted on PLP-dependent enzymes in our laboratory during the past decade has not only resulted in deeper understanding of their structure and function but also raised several new questions regarding substrate recognition, reaction specificity, role of active site residues in the catalytic reaction, mechanism of catalysis and potential applications of these enzymes. This thesis is an attempt to answer some of these questions. The thesis also presents the structure and function of a new protein, Salmonella typhimurium pyridoxal kinase, the enzyme that provides PLP for PLP-dependent enzymes.
Single crystal X-ray diffraction technique is the most powerful tool currently available for the elucidation of the three-dimensional structures of proteins and other biological macromolecules and for revealing the relationship between their structure and function. X-ray diffraction studies have provided in depth understanding of the topology of secondary structural elements in the three-dimensional structures of proteins, the hierarchical organization of protein domains, structural basis for the substrate specificity of enzymes, intricate details of mechanisms of enzyme catalyzed reactions, allosteric regulation of enzyme activity, mechanisms of feed-back inhibition, structural basis of protein stability, symmetry of oligomeric proteins and their possible biological implications and a myriad of other biochemical and biophysical properties of proteins. The work reported in this thesis is primarily based on X-ray diffraction…
Advisors/Committee Members: Murthy, M R N (advisor).
Subjects/Keywords: Pyridoxal Kinase; Pyridoxal 5'-Phosphate Enzymes; Salmonella Typhimurium Arginine Decarboxylase; Escherechia Coil; Latent Tuberculosis Infection; E. coli Diaminopropionate Ammonia Lyase; S. typhimurium Arginine Decarboxylase; Diaminopropionate Ammonia Lyase; Molecular Biophysics
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APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
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APA (6th Edition):
Deka, G. (2018). Structural and Functional Studies on Pyridoxal Kinase and Pyridoxal 5′-phosphate Dependent Enzymes. (Doctoral Dissertation). Indian Institute of Science. Retrieved from http://etd.iisc.ac.in/handle/2005/3779
Chicago Manual of Style (16th Edition):
Deka, Geeta. “Structural and Functional Studies on Pyridoxal Kinase and Pyridoxal 5′-phosphate Dependent Enzymes.” 2018. Doctoral Dissertation, Indian Institute of Science. Accessed January 22, 2021.
http://etd.iisc.ac.in/handle/2005/3779.
MLA Handbook (7th Edition):
Deka, Geeta. “Structural and Functional Studies on Pyridoxal Kinase and Pyridoxal 5′-phosphate Dependent Enzymes.” 2018. Web. 22 Jan 2021.
Vancouver:
Deka G. Structural and Functional Studies on Pyridoxal Kinase and Pyridoxal 5′-phosphate Dependent Enzymes. [Internet] [Doctoral dissertation]. Indian Institute of Science; 2018. [cited 2021 Jan 22].
Available from: http://etd.iisc.ac.in/handle/2005/3779.
Council of Science Editors:
Deka G. Structural and Functional Studies on Pyridoxal Kinase and Pyridoxal 5′-phosphate Dependent Enzymes. [Doctoral Dissertation]. Indian Institute of Science; 2018. Available from: http://etd.iisc.ac.in/handle/2005/3779
26.
Nguyen Truax, Fayette Khue.
Factors Affecting Medication Adherence among Vietnamese Immigrants with Latent Tuberculosis Infection: A Mixed Design.
Degree: Nursing, 2016, UCLA
URL: http://www.escholarship.org/uc/item/3b47f64v
► ABSTRACT OF THE DISSERTATIONFactors Affecting Medication Adherence among Vietnamese Immigrantswith Latent Tuberculosis Infection: A Mixed DesignbyFayette Nguyen TruaxDoctor of Philosophy in NursingUniversity of California, Los…
(more)
▼ ABSTRACT OF THE DISSERTATIONFactors Affecting Medication Adherence among Vietnamese Immigrantswith Latent Tuberculosis Infection: A Mixed DesignbyFayette Nguyen TruaxDoctor of Philosophy in NursingUniversity of California, Los Angeles, 2016Professor Adeline M. Nyamathi, Chair Completion of latent tuberculosis infection (LTBI) treatment among foreign-born Asians in the United States (US) is suboptimal, thus leading to high rates of reactivation tuberculosis (TB) among this population. Approximately 77% of TB cases in the US are from reactivation TB and foreign-born Asians have a higher reactivation rate compared to Blacks, Hispanics and Whites. In Orange County (O.C.), the annual TB case rate continues to remain steady at 6.0 cases per 100,000 in 2014 with foreign-born persons from Vietnam leading with a TB rate of 49.7%, Mexico at 14.4% and the Philippines at 12.6%. Overall the high number of active TB cases among Vietnamese immigrants, coupled with low LTBI treatment completion rate of approximately 50.1% in the overall Asian population, presents an important challenge to the national strategy of eliminating TB (Li et al., 2010). At this time, there is limited data on Vietnamese immigrants with LTBI in the US. The purpose of this mixed methods study is to identify the factors related to LTBI treatment acceptance and completion in addition to exploring the decision-making process of LTBI treatment adherence among Vietnamese immigrants. Predictors for phase 1 included: socio-demographic characteristics, basic health history, behavioral survey scores measured by Morisky Medication Adherence Scale (MMAS-8), Champion Health Belief Model Scale (CHBMS-29) and the Self-Efficacy for Appropriate Medication Use (SEAM-9). Significant predictors for multivariate analysis for treatment acceptance included individuals with a history of smoking and recent contact with an infectious TB case. For treatment completion, the top two most significant predictors in the univariate analysis included age group between 18-44 years and current employment. No significant predictors were identified in the multivariate analysis for treatment completion. There were also no significant correlations identified between the psychosocial measurements (SEAM-9, CHBMS-29, MMAS-8) and treatment completion. In phase 2, a decision-making grounded theory model entitled “The Decision-Making Model for Latent TB Infection Treatment Acceptance and Completion” was developed from the stories and testimonies of 17 Vietnamese participants. Three primary decision-making points were identified that was critical to the development of the proposed model: treatment acceptance, treatment initiation and treatment completion. Three categories emerged from participants’ data that were directly related to the decision to accept LTBI treatment, “beliefs”, “TB awareness” and “trust in healthcare”. Findings revealed the only category to influence treatment initiation was “barriers” to scheduling. Lastly, the decision to maintain adherence and complete treatment were strongly…
Subjects/Keywords: Nursing; Public health; Immigrant; Infection; Latent; Tuberculosis; Vietnamese
…177
B. The Decision-Making Model for Latent Tuberculosis Infection
Treatment Acceptance and… …latent TB
infection treatment among low-income populations. Presented at the Annual
Western… …Morisky, D. (2015). |Poster|. Latent TB
Infection among Vietnamese Immigrants… …Truax, F., Stemmler, M.S. (2014). |Podium| Latent TB
Infection among Vietnamese… …x29; have
latent tuberculosis infection (LTBI), and on average 5-10% of these…
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
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APA (6th Edition):
Nguyen Truax, F. K. (2016). Factors Affecting Medication Adherence among Vietnamese Immigrants with Latent Tuberculosis Infection: A Mixed Design. (Thesis). UCLA. Retrieved from http://www.escholarship.org/uc/item/3b47f64v
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Nguyen Truax, Fayette Khue. “Factors Affecting Medication Adherence among Vietnamese Immigrants with Latent Tuberculosis Infection: A Mixed Design.” 2016. Thesis, UCLA. Accessed January 22, 2021.
http://www.escholarship.org/uc/item/3b47f64v.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Nguyen Truax, Fayette Khue. “Factors Affecting Medication Adherence among Vietnamese Immigrants with Latent Tuberculosis Infection: A Mixed Design.” 2016. Web. 22 Jan 2021.
Vancouver:
Nguyen Truax FK. Factors Affecting Medication Adherence among Vietnamese Immigrants with Latent Tuberculosis Infection: A Mixed Design. [Internet] [Thesis]. UCLA; 2016. [cited 2021 Jan 22].
Available from: http://www.escholarship.org/uc/item/3b47f64v.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Nguyen Truax FK. Factors Affecting Medication Adherence among Vietnamese Immigrants with Latent Tuberculosis Infection: A Mixed Design. [Thesis]. UCLA; 2016. Available from: http://www.escholarship.org/uc/item/3b47f64v
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
27.
송, 호림.
The status of latent tuberculosis test and biochemical test for a person undergoing a military conscription examination.
Degree: 2017, Ajou University
URL: http://repository.ajou.ac.kr/handle/201003/16501
;
http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000025894
► According to the data, 5~10% of Tuberculosis (TB) carriers are possible to be converted to Active TB. Korea was the first of TB attack rate…
(more)
▼ According to the data, 5~10% of Tuberculosis (TB) carriers are possible to be converted to Active TB. Korea was the first of TB attack rate among OECD members in 2014, however, it shows gradually the decrease trend with the year 2011 as the peak.
PURPOSE OF RESEARCH: Based on the analyzed data about the blood test result from the recipients of military conscription examination and the status of the all of the country TB carrier, this research compared and analyzed Biochemical examination(7types and BMI-index) data between TB carrier and Negative collected from Seoul, Daejeon and Kyeong-In Military Manpower Administration. The environment of Army-camp is worse condition for disease. The treatment for TB carrier before joining the army should be very important. Under the present unclear data for TB carrier, the clear regional data will be useful to set the national health care policy up and helpful to make a plan of the national Health Project. So, the main purpose of this research is beforehand to prevent converting to Active TB with the investigation and the treatment TB carrier of the recipients of military conscription examination.
METHOD OF RESEARCH: The study participants as below are analyzed.
- age: Over 19 years
- Target area and the condition: 1) Seoul Military Manpower Administration: 18,541 the recipients from 23,Jan,2017 ~ 28,Apr,2017 2) Daejeon Military Manpower Administration: 8,513 the recipients from 23,Jan,2017 ~ 28,Apr,2017 3) Kyeong-In Military Manpower Administration: 10,681 the recipients from 23,Jan,2017 ~ 28,Apr,2017
RESULT OF RESEARCH: It showed the meaningful result between Glucose and TB carrier by the data from Seoul and Daejeon Military Manpower Administration and It showed the meaningful result between Dyslipidemia and TB carrier by the data from Kyeong-In Military Manpower Administration Based on this result, TB carrier is estimated to be the correlation with Glucose and Dyslipidemia. This suggests that a carrier of latent tuberculosis may have an association with dyslipidemia and glucose, but more extensive studies should be conducted considering the control of variables, regional characteristics and lifestyle. We will also have to research the correlation between Latent TB/TB bacillus and the various diseases more and more. Through this research we found that the infection rate of Latent TB in Korea is not low-level and understood the necessity of the continuous management and supervision. Henceforward, the limitation of this research will have to be improved and we must make an effort to lower TB attack rate and death rate with investigating the corrective infection cause by Contrastive study and Epidemiological investigation.
잠복결핵 감염자의 5-10%는 결핵으로 발전할 가능성을 지니고 있으며, 우리나라는 2014년 OECD국가 중 결핵 발생률이 1위에 달하고 있으며, 2011년을 정점으로 감소추세에 있다.
연구목적: 이 연구는 병역판정검사 대상자의 혈액검사 결과를 토대로 전국 잠복결핵 보균자 현황과 서울, 대전, 경인지방병무청 잠복결핵 보균자와 음성자간 생화학검사(7종과 BMI지수)를 분석 하였다. 군부대 환경은 질병 노출에 취약한 구조이며, 군 입대 전 잠복결핵 보균자 치료는 무엇보다 중요하다고 할 수 있다. 또한, 병역판정검사 대상자의 잠복결핵 보균자를 치료함으로써 활동성 결핵으로 발전할 가능성을 차단하고, 잠복결핵 감염자 파악이 제대로 되지 않고 있는…
Advisors/Committee Members: 보건대학원, 201530010, 송, 호림.
Subjects/Keywords: Latent tuberculosis infection; T. cholesterol; Triglycerides; Body MassIndex; γ-guanosine triphosphate; Blood Urea Nitrogen; Aspartate aminotransferase; Alanine aminotransaminase; BUN; Glucose; TG; TC. AST; ALT; γ-GTP; BMI; 잠복결핵
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
송, . (2017). The status of latent tuberculosis test and biochemical test for a person undergoing a military conscription examination. (Thesis). Ajou University. Retrieved from http://repository.ajou.ac.kr/handle/201003/16501 ; http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000025894
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
송, 호림. “The status of latent tuberculosis test and biochemical test for a person undergoing a military conscription examination.” 2017. Thesis, Ajou University. Accessed January 22, 2021.
http://repository.ajou.ac.kr/handle/201003/16501 ; http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000025894.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
송, 호림. “The status of latent tuberculosis test and biochemical test for a person undergoing a military conscription examination.” 2017. Web. 22 Jan 2021.
Vancouver:
송 . The status of latent tuberculosis test and biochemical test for a person undergoing a military conscription examination. [Internet] [Thesis]. Ajou University; 2017. [cited 2021 Jan 22].
Available from: http://repository.ajou.ac.kr/handle/201003/16501 ; http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000025894.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
송 . The status of latent tuberculosis test and biochemical test for a person undergoing a military conscription examination. [Thesis]. Ajou University; 2017. Available from: http://repository.ajou.ac.kr/handle/201003/16501 ; http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000025894
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
28.
Σπυρίδης, Νικόλαος.
Βραχύ σχήμα χημειοπροφύλαξης σε παιδιά με φυματιώδη μόλυνση.
Degree: 2007, National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ)
URL: http://hdl.handle.net/10442/hedi/23667
► This is a 150 pages doctoral document that contains 31 tables, 262 references and divided in two major sections: a general section that describes the…
(more)
▼ This is a 150 pages doctoral document that contains 31 tables, 262 references and divided in two major sections: a general section that describes the impact of tuberculosis in the world and a specific section that describes the aim, design and results of the study. In the general section there is a description of the “TB epidemic” that emerged since 1985 mainly due to the increasing incidence of HIV and immigration. The chapters of the general section also describe the delayed reaction of the international community in the fight against TB and the unique characteristics of the Paediatric tuberculosis. In the second chapter, we also describe the failure of major health organizations to consider the importance of Paediatric TB as a major strategic tool to control the disease. In the epidemiology section, we define tuberculosis, tuberculosis infection and the reasons why LTBI is in fact a subclinical disease. Other topics also covered were the pathophysiology of infection, use of TB drugs, treatment of tuberculosis and chemoprophylaxis of tuberculosis infection, the surge of MDR TB and finally the reasons behind the poor compliance to treatment of children and adults. In the chapter “Aim of the study”, we analyze the reasons why children should be studied separately from adults. Also, in that section we describe all the arguments that support the use of combination chemotherapy instead of monotherapy for the treatment of LTBI. The study was conducted in two time periods. In period 1, enrolment of patients began January 1st 1995 and ended December 31st 1998, while in the second period (period 2) enrolment started January 1st 1999 and ended December 31st 2002. During the next 3 years (2003-2005) we continued to follow all patients until three years were completed from the time the last patient was enrolled. During the first period, we compared the internationally recommended regimen of 9 months INH chemoprophylaxis for children with LTBI, with a short 4 month course of INH+RIF. During the second period we compared two short course regimes (3 months Vs 4 months) of INH+RIF. The study design was identical for the two periods and patients were randomly allocated to the different groups on the basis of their clinic number (odd or even). The recruitment criteria followed the international definitions for LTBI. Patient adherence was defined by the presence of drug metabolites in the urine, while drug related side effects were documented following the completion of a questionnaire and in certain cases by determination of liver enzymes. Follow up with chest radiographs in predetermined time periods continued up to 3 years after completion of treatment. Evaluation was completed following regular telephone communication between the clinic and the patient’s family. ................................................................................................................
Η διδακτορική διατριβή είναι ανεπτυγμένη σε 150 περίπου σελίδες, περιέχει 31 πίνακες, 262 βιβλιογραφικές αναφορές και περιλαμβάνει γενικό και ειδικό…
Subjects/Keywords: Φυματίωση; Χημειοπροφύλαξη; Παιδιά; Λανθάνουσα φυματιώδης μόλυνση; Tuberculosis; Chemoprophylaxis; Children; Latent tuberculosis infection
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APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Σπυρίδης, . . (2007). Βραχύ σχήμα χημειοπροφύλαξης σε παιδιά με φυματιώδη μόλυνση. (Thesis). National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ). Retrieved from http://hdl.handle.net/10442/hedi/23667
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Σπυρίδης, Νικόλαος. “Βραχύ σχήμα χημειοπροφύλαξης σε παιδιά με φυματιώδη μόλυνση.” 2007. Thesis, National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ). Accessed January 22, 2021.
http://hdl.handle.net/10442/hedi/23667.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Σπυρίδης, Νικόλαος. “Βραχύ σχήμα χημειοπροφύλαξης σε παιδιά με φυματιώδη μόλυνση.” 2007. Web. 22 Jan 2021.
Vancouver:
Σπυρίδης . Βραχύ σχήμα χημειοπροφύλαξης σε παιδιά με φυματιώδη μόλυνση. [Internet] [Thesis]. National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ); 2007. [cited 2021 Jan 22].
Available from: http://hdl.handle.net/10442/hedi/23667.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Σπυρίδης . Βραχύ σχήμα χημειοπροφύλαξης σε παιδιά με φυματιώδη μόλυνση. [Thesis]. National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ); 2007. Available from: http://hdl.handle.net/10442/hedi/23667
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Virginia Tech
29.
Stimson, Erin Leigh.
Detection of Feline Leukemia Virus in Feline Bone Marrow Using Polymerase Chain Reaction.
Degree: MS, Veterinary Medical Sciences, 2000, Virginia Tech
URL: http://hdl.handle.net/10919/31627
► Detection of Feline Leukemia Virus in Bone Marrow Using Polymerase Chain Reaction Erin Leigh Stimson Latent feline leukemia virus (FeLV) infections, in which proviral DNA…
(more)
▼ Detection of Feline Leukemia Virus in Bone Marrow Using Polymerase Chain Reaction
Erin Leigh Stimson
Latent feline leukemia virus (FeLV) infections, in which proviral DNA is integrated into host DNA, but not actively transcribed, are suspected to be associated with many diseases. Bone marrow is the suspected site of the majority of
latent infections. The purpose of this study was to determine if polymerase chain reaction (PCR) could detect FeLV proviral DNA in bone marrow and provide a method of detecting
latent infections. Blood and bone marrow samples from fifty cats and bone marrow from one fetus were collected; sixteen had FeLV-associated diseases. Serum ELISA, blood and bone marrow immunofluorescent antibody test (IFA), and blood and bone marrow PCR were performed on each cat, and IFA and PCR on bone marrow of the fetus. Forty-one cats were FeLV negative. Five cats and one fetus were persistently infected with FeLV. Four cats were discordant; two ELISA positive with other tests negative, one bone marrow IFA negative with other tests positive, and one bone marrow IFA positive with other tests negative. No cats were positive on bone marrow PCR only. These results indicate that PCR can detect FeLV in bone marrow, but no cats in this study harbored FeLV only in the bone marrow. Not all cats with FeLV-associated diseases are persistently or latently infected with FeLV.
Advisors/Committee Members: Troy, Gregory C. (committeechair), Toth, Thomas E. (committee member), Forrester, S. Dru (committee member).
Subjects/Keywords: polymerase chain reaction; feline leukemia virus; bone marrow; latent infection
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APA ·
Chicago ·
MLA ·
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CSE |
Export
to Zotero / EndNote / Reference
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APA (6th Edition):
Stimson, E. L. (2000). Detection of Feline Leukemia Virus in Feline Bone Marrow Using Polymerase Chain Reaction. (Masters Thesis). Virginia Tech. Retrieved from http://hdl.handle.net/10919/31627
Chicago Manual of Style (16th Edition):
Stimson, Erin Leigh. “Detection of Feline Leukemia Virus in Feline Bone Marrow Using Polymerase Chain Reaction.” 2000. Masters Thesis, Virginia Tech. Accessed January 22, 2021.
http://hdl.handle.net/10919/31627.
MLA Handbook (7th Edition):
Stimson, Erin Leigh. “Detection of Feline Leukemia Virus in Feline Bone Marrow Using Polymerase Chain Reaction.” 2000. Web. 22 Jan 2021.
Vancouver:
Stimson EL. Detection of Feline Leukemia Virus in Feline Bone Marrow Using Polymerase Chain Reaction. [Internet] [Masters thesis]. Virginia Tech; 2000. [cited 2021 Jan 22].
Available from: http://hdl.handle.net/10919/31627.
Council of Science Editors:
Stimson EL. Detection of Feline Leukemia Virus in Feline Bone Marrow Using Polymerase Chain Reaction. [Masters Thesis]. Virginia Tech; 2000. Available from: http://hdl.handle.net/10919/31627
30.
Νικολοπούλου, Μαρία-Μελίτα.
Έλεγχος λανθάνουσας φυματίωσης με την ταυτόχρονη διενέργεια φυματινοαντίδρασης και δοκιμασίας προσδιορισμού ιντερφερόνης-γ σε πληθυσμιακές ομάδες με αυξημένο κίνδυνο ανάπτυξης TBC.
Degree: 2012, University of Ioannina; Πανεπιστήμιο Ιωαννίνων
URL: http://hdl.handle.net/10442/hedi/26950
► Tuberculosis (TB) remains one of the most fatal infectious diseases worldwide, accounting for more than 2 million deaths annually. One-third of the world’s population is…
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▼ Tuberculosis (TB) remains one of the most fatal infectious diseases worldwide, accounting for more than 2 million deaths annually. One-third of the world’s population is infected with Mycobacterium tuberculosis while World Health Organization estimates a prevalence of 19 new cases/ 100 000/ year in Greece, among the highest in Western Europe. A critical step in the elimination of tuberculosis would be the prompt diagnosis of latent tuberculosis. For more than a century and until recently, Mantoux has been the only method for the assessment of infection with the Mycobacterium of tuberculosis. The above technique has some drawbacks, the most important of which is the occurrence of false positive results due to infection with non-tuberculous mycobacteria or after the vaccination with BCG that has as a result the application of unnecessary treatment. A major breakthrough in recent years has been the development of new techniques, called interferon-γ release assays. With the above techniques, T cell release of interferon- γ in response to stimulation to antigens specific for the Mycobacterium of tuberculosis, is measured. Two assays have become commercially available: QuantiFERON – TB Gold assay and T-SPOT. TB. A major challenge is the prompt diagnosis and treatment of tuberculosis in the elderly who are at increased risk of incurring TBC reactivation due to the impairment of cell immunity and the co-existence of acute or chronic diseases. In Greece, a large percentage of geriatric population lives in nursing homes. There have been only a few studies investigating the effect of contact with people suffering from active tuberculosis in such settings while there are no explicit and unified recommendations in regard policies and practices of TB screening among elderly residents and staff working in nursing homes. In Greece there have been no studies comparing the efficacy of interferon-γ release assays and Mantoux in BCG vaccinated populations and estimating the value of IGRA in the diagnosis of latent tuberculosis in the elderly. The aim of the first phase of the present study is to compare Mantoux and the interferon-γ release assays, in particular Quantiferon TB Gold in tube assay, in Greek Army recruits that have been vaccinated with BCG in their childhood and had not been exposed to tuberculosis in the past. We also studied the effect on TST of the interval since BCG vaccination. Of 56368 subjects who enlisted at all recruitment centers throughout Greece 1765 were enrolled in our study. We excluded 15 recruits with chronic medical conditions, because of receiving treatment for either active or latent tuberculosis, and due recent exposure to patients suffering from active tuberculosis. A total number of 1750 recruits were finally enrolled in our study. Of a total of 1750 subject 96 (5.4%) were TST-positive with an induration size ≥ 10 mm. The 111 participants with TST≥0 mm were divided in four groups according to the defined TST grouping values. The first group included subjects with TST induration 1-4 mm the second group…
Subjects/Keywords: Φυματίωση, Λανθάνουσα; Φυματινοαντίδραση Mantoux; Δοκιμασία QuantiFERON-TB Gold - In Tube; Εμβολιασμένοι με BCG; Ηλικιωμένοι; Latent tuberculosis infection; Mantoux method; Interferon - γ release assay (QFT - GIT); BCG vaccinated; Elderly
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APA (6th Edition):
Νικολοπούλου, . . (2012). Έλεγχος λανθάνουσας φυματίωσης με την ταυτόχρονη διενέργεια φυματινοαντίδρασης και δοκιμασίας προσδιορισμού ιντερφερόνης-γ σε πληθυσμιακές ομάδες με αυξημένο κίνδυνο ανάπτυξης TBC. (Thesis). University of Ioannina; Πανεπιστήμιο Ιωαννίνων. Retrieved from http://hdl.handle.net/10442/hedi/26950
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Νικολοπούλου, Μαρία-Μελίτα. “Έλεγχος λανθάνουσας φυματίωσης με την ταυτόχρονη διενέργεια φυματινοαντίδρασης και δοκιμασίας προσδιορισμού ιντερφερόνης-γ σε πληθυσμιακές ομάδες με αυξημένο κίνδυνο ανάπτυξης TBC.” 2012. Thesis, University of Ioannina; Πανεπιστήμιο Ιωαννίνων. Accessed January 22, 2021.
http://hdl.handle.net/10442/hedi/26950.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Νικολοπούλου, Μαρία-Μελίτα. “Έλεγχος λανθάνουσας φυματίωσης με την ταυτόχρονη διενέργεια φυματινοαντίδρασης και δοκιμασίας προσδιορισμού ιντερφερόνης-γ σε πληθυσμιακές ομάδες με αυξημένο κίνδυνο ανάπτυξης TBC.” 2012. Web. 22 Jan 2021.
Vancouver:
Νικολοπούλου . Έλεγχος λανθάνουσας φυματίωσης με την ταυτόχρονη διενέργεια φυματινοαντίδρασης και δοκιμασίας προσδιορισμού ιντερφερόνης-γ σε πληθυσμιακές ομάδες με αυξημένο κίνδυνο ανάπτυξης TBC. [Internet] [Thesis]. University of Ioannina; Πανεπιστήμιο Ιωαννίνων; 2012. [cited 2021 Jan 22].
Available from: http://hdl.handle.net/10442/hedi/26950.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Νικολοπούλου . Έλεγχος λανθάνουσας φυματίωσης με την ταυτόχρονη διενέργεια φυματινοαντίδρασης και δοκιμασίας προσδιορισμού ιντερφερόνης-γ σε πληθυσμιακές ομάδες με αυξημένο κίνδυνο ανάπτυξης TBC. [Thesis]. University of Ioannina; Πανεπιστήμιο Ιωαννίνων; 2012. Available from: http://hdl.handle.net/10442/hedi/26950
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
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