subject:(Laser speckle contrast imaging)

University of Texas – Austin

1. Arkin, Jeremy Sandon. Investigation into optimizing laser speckle contrast imaging illumination.

Degree: MSin Engineering, Biomedical Engineering, 2017, University of Texas – Austin

► The primary purpose of this work is to optimize the illumination parameters used for laser speckle imaging and investigate how spatial modulation of the light… (more)

Subjects/Keywords: Laser speckle contrast imaging; Illumination

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APA (6^th Edition):

Arkin, J. S. (2017). Investigation into optimizing laser speckle contrast imaging illumination. (Masters Thesis). University of Texas – Austin. Retrieved from http://hdl.handle.net/2152/61564

Chicago Manual of Style (16^th Edition):

Arkin, Jeremy Sandon. “Investigation into optimizing laser speckle contrast imaging illumination.” 2017. Masters Thesis, University of Texas – Austin. Accessed February 25, 2021. http://hdl.handle.net/2152/61564.

MLA Handbook (7^th Edition):

Arkin, Jeremy Sandon. “Investigation into optimizing laser speckle contrast imaging illumination.” 2017. Web. 25 Feb 2021.

Vancouver:

Arkin JS. Investigation into optimizing laser speckle contrast imaging illumination. [Internet] [Masters thesis]. University of Texas – Austin; 2017. [cited 2021 Feb 25]. Available from: http://hdl.handle.net/2152/61564.

Council of Science Editors:

Arkin JS. Investigation into optimizing laser speckle contrast imaging illumination. [Masters Thesis]. University of Texas – Austin; 2017. Available from: http://hdl.handle.net/2152/61564

University of Texas – Austin

2. -0656-3800. Laser speckle contrast imaging for intraoperative monitoring of cerebral blood flow.

Degree: PhD, Biomedical Engineering, 2016, University of Texas – Austin

URL: http://hdl.handle.net/2152/63850

► Ensuring adequate blood flow during surgical procedures is crucial, as prolonged ischemia can result in tissue death and lead to poor clinical outcomes. This is… (more)

▼ Ensuring adequate blood flow during surgical procedures is crucial, as prolonged ischemia can result in tissue death and lead to poor clinical outcomes. This is especially important during neurosurgery, since the brain relies on a constant supply of cerebral blood flow (CBF) to maintain normal function. Intraoperative blood flow monitoring tools are essential to detect ischemia in a timely manner, and allow surgical correction before the onset of irreversible brain injury. Laser speckle contrast imaging (LSCI) is an optical imaging method that provides blood flow maps with high spatiotemporal resolution, and overcomes many of the limitations of current intraoperative monitoring technologies. The objective of this dissertation is to demonstrate that LSCI is an effective tool for blood flow monitoring during neurosurgery, and to optimize and improve LSCI technology for clinical use. This research has two primary elements: assessing the LSCI instrumentation components in a controlled laboratory setting, and evaluating the clinical performance of LSCI during neurosurgery. The laboratory study aims to determine the optimal specifications for the clinical instrument design, using controlled static and microfluidic flow experiments. Two of the main components of the LSCI instrument are the camera used for recording, and the laser used for coherent illumination of the tissue. Thus, a broad camera and laser comparison was performed spanning a wide array of available hardware options to determine which specifications are the most important for reliable and highly sensitive flow measurements. The two-phase clinical study aims to demonstrate the performance and utility of LSCI in a neurosurgical setting as a potential tool for real-time, continuous, and noninvasive image guidance. These studies demonstrate that LSCI can produce blood flow maps consistent with expected physiological trends, and show the impact of instrument design and image acquisition techniques on image quality and quantitative flow assessment. The results from both the laboratory and clinical studies can be used to design a more sensitive and robust LSCI system, which increases its value as an intraoperative tool for monitoring blood flow. LSCI has the potential to be the next generation of neurosurgical image guidance for blood flow visualization, and the work presented in this dissertation can accelerate its clinical adoption. Advisors/Committee Members: Dunn, Andrew Kenneth, 1970- (advisor), Fox, Jr., Douglas J (committee member), Rylander, III, Henry G (committee member), Tunnell, James W (committee member), Emelianov, Stanislav Y (committee member).

Subjects/Keywords: Laser speckle contrast imaging; Cerebral blood flow; Intraoperative imaging

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APA (6^th Edition):

-0656-3800. (2016). Laser speckle contrast imaging for intraoperative monitoring of cerebral blood flow. (Doctoral Dissertation). University of Texas – Austin. Retrieved from http://hdl.handle.net/2152/63850

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete

Chicago Manual of Style (16^th Edition):

-0656-3800. “Laser speckle contrast imaging for intraoperative monitoring of cerebral blood flow.” 2016. Doctoral Dissertation, University of Texas – Austin. Accessed February 25, 2021. http://hdl.handle.net/2152/63850.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete

MLA Handbook (7^th Edition):

-0656-3800. “Laser speckle contrast imaging for intraoperative monitoring of cerebral blood flow.” 2016. Web. 25 Feb 2021.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete

Vancouver:

-0656-3800. Laser speckle contrast imaging for intraoperative monitoring of cerebral blood flow. [Internet] [Doctoral dissertation]. University of Texas – Austin; 2016. [cited 2021 Feb 25]. Available from: http://hdl.handle.net/2152/63850.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete

Council of Science Editors:

-0656-3800. Laser speckle contrast imaging for intraoperative monitoring of cerebral blood flow. [Doctoral Dissertation]. University of Texas – Austin; 2016. Available from: http://hdl.handle.net/2152/63850

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete

University of Texas – Austin

3. Davis, Mitchell Alan. Three dimensional simulation of functional neuro-vascular imaging.

Degree: PhD, Electrical and Computer Engineering, 2014, University of Texas – Austin

URL: http://hdl.handle.net/2152/38225

► Functional optical imaging has become a powerful tool for measuring physiological parameters in the brain without disrupting normal physiology. Fluorescence lifetime imaging (FLIM) has been… (more)

▼ Functional optical imaging has become a powerful tool for measuring physiological parameters in the brain without disrupting normal physiology. Fluorescence lifetime imaging (FLIM) has been shown to allow near real time mapping of oxygen tension in plasma (pO2), and Laser Speckle Contrast Imaging (LSCI) has been demonstrated to provide qualitative assessments of blood flow in the cortex. However, as both of these methods provide physiological parameters based on the spatial sampling of photons arriving at a detector, it is crucially important to understand either where the photons originated, in the case of FLIM, or which moving particles the photons have sampled, in the case of LSCI. Traditionally, these questions have been difficult to solve because of the heterogeneity of the distribution of particles which contribute to the measured signal. In both FLIM and LSCI, for example, only the light which samples the intravascular space will contribute to the signal. While analytical methods have proven to be successful at predicting the imaging depth of homogeneous materials, they are not able to predict imaging depth when measuring a fluorophore or a moving particle that is only present inside blood vessels. Unlike analytical methods, numerical methods can be used to approximate light propagation in an arbitrary geometry. While both deterministic and stochastic models of light propagation can, and have been, successfully employed to determine light fluence in an arbitrary geometry, deterministic methods are not well suited to the task of simulating light propagation in large volumes of turbid media. For this reason, three dimensional Monte Carlo simulations of light propagation combined with high resolution vascular anatomy were used to directly simulate FLIM and LSCI in the brain. Using these simulations, the imaging depth, degree of multiple scattering, and sensitivity of LSCI and FLIM to physiological changes were determined. Advisors/Committee Members: Dunn, Andrew Kenneth, 1970- (advisor), Pearce, John (committee member), Thomas, Robert (committee member), Tunnell, James (committee member), Ling, Hao (committee member).

Subjects/Keywords: Laser-tissue interactions; Vascular fluorescence imaging; Speckle contrast imaging; Dynamic light scattering; Blood flow imaging

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APA (6^th Edition):

Davis, M. A. (2014). Three dimensional simulation of functional neuro-vascular imaging. (Doctoral Dissertation). University of Texas – Austin. Retrieved from http://hdl.handle.net/2152/38225

Chicago Manual of Style (16^th Edition):

Davis, Mitchell Alan. “Three dimensional simulation of functional neuro-vascular imaging.” 2014. Doctoral Dissertation, University of Texas – Austin. Accessed February 25, 2021. http://hdl.handle.net/2152/38225.

MLA Handbook (7^th Edition):

Davis, Mitchell Alan. “Three dimensional simulation of functional neuro-vascular imaging.” 2014. Web. 25 Feb 2021.

Vancouver:

Davis MA. Three dimensional simulation of functional neuro-vascular imaging. [Internet] [Doctoral dissertation]. University of Texas – Austin; 2014. [cited 2021 Feb 25]. Available from: http://hdl.handle.net/2152/38225.

Council of Science Editors:

Davis MA. Three dimensional simulation of functional neuro-vascular imaging. [Doctoral Dissertation]. University of Texas – Austin; 2014. Available from: http://hdl.handle.net/2152/38225

4. Khalil, Adil. Processing of laser speckle contrast images : study of mathematical models and use of nonlinear analyses to investigate the impact of aging on microvascular blood flow : Traitement d’images de speckle laser : étude à partir de modèles mathématiques et utilisation d’analyses non linéaires pour appréhender l’effet de l’âge sur la microcirculation sanguine.

Degree: Docteur es, Traitement des images et du signal, 2017, Angers

URL: http://www.theses.fr/2017ANGE0006

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Le vieillissement est un facteur de risque des maladies cardiovasculaires. Il est associé à des altérations fonctionnelles et structurelles du système vasculaire.Une étude approfondie du… (more)

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Le vieillissement est un facteur de risque des maladies cardiovasculaires. Il est associé à des altérations fonctionnelles et structurelles du système vasculaire.Une étude approfondie du processus de vieillissement et le développement de systèmes d’imagerie et des traitements de données associés deviennent donc une priorité. Par l’analyse d’images de contraste par speckle laser (LSCI), l’objectif de cette thèse est d’étudier l’influence de l’âge sur la micro circulation.Pour ce faire, des données de LSCI ont été acquises sur l’avant-bras de sujets sains jeunes et âgés. A partir de modèles mathématiques, nous avons déterminé la vitesse des érythrocytes de la micro circulation chez les deux groupes de sujets. Par ailleurs, nous avons également mené une étude de la complexité de séries temporelles d’ LSCI s’appuyant sur des mesures d’entropie multi échelle. Nos résultats montrent que : 1) le groupe de sujets plus âgés présente des valeurs de vitesse des globules rouges significativement plus élevées que celles des sujets jeunes à l’hyperémie réactive post-occlusive; 2) les fluctuations des séries temporelles de LSCI dans le groupe des sujets jeunes ont une complexité supérieure à celles du groupe de sujets âgés. Ces modifications observées sur la micro circulation pourraient être attribuées à des modifications du système vasculaire dans son ensemble. La compréhension de ces altérations pourrait conduire à de nouvelles perspectives en matière de prévention et de traitement des pathologies liées à l’âge.

Aging is a primary risk factor for cardiovascular diseases. It is associated with functional and structural alterations in the vascular system. Therefore, a deep study of the aging process and the development of imaging systems and associated processing become of the utmost importance. By processing laser speckle contrast images (LSCI), this PhD work aims at studying the influence of age on microcirculation. In our work, LSCI data were acquired from the skin forearm of healthy subjects, subdivided into two age groups (younger and older). From mathematical models, we determined red blood cells velocity in microcirculation in the two groups of subjects. Moreover, we applied multiscale entropy-based algorithms to LSCI time series in order to study the complexity of microvascular signals. Our main findings are: 1) the older group has significantly higher velocity values than the younger group at post-occlusive reactive hyperaemia; 2) LSCI fluctuations in the younger group have significantly higher complexity than those of the older group. Age-related changes in skin microcirculation can be attributed to alterations in the vascular system as a whole. Understanding these changes in the microcirculatory system may give new insights for prevention and treatment of age-related diseases

Advisors/Committee Members: Humeau-Heurtier, Anne (thesis director).

Subjects/Keywords: Image de contraste par speckle laser; Analyse non linéaire; Complexité; Laser speckle contrast imaging; Image processing; Nonlinear analysis; Complexity; Entropy; 610

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APA (6^th Edition):

Khalil, A. (2017). Processing of laser speckle contrast images : study of mathematical models and use of nonlinear analyses to investigate the impact of aging on microvascular blood flow : Traitement d’images de speckle laser : étude à partir de modèles mathématiques et utilisation d’analyses non linéaires pour appréhender l’effet de l’âge sur la microcirculation sanguine. (Doctoral Dissertation). Angers. Retrieved from http://www.theses.fr/2017ANGE0006

Chicago Manual of Style (16^th Edition):

Khalil, Adil. “Processing of laser speckle contrast images : study of mathematical models and use of nonlinear analyses to investigate the impact of aging on microvascular blood flow : Traitement d’images de speckle laser : étude à partir de modèles mathématiques et utilisation d’analyses non linéaires pour appréhender l’effet de l’âge sur la microcirculation sanguine.” 2017. Doctoral Dissertation, Angers. Accessed February 25, 2021. http://www.theses.fr/2017ANGE0006.

MLA Handbook (7^th Edition):

Khalil, Adil. “Processing of laser speckle contrast images : study of mathematical models and use of nonlinear analyses to investigate the impact of aging on microvascular blood flow : Traitement d’images de speckle laser : étude à partir de modèles mathématiques et utilisation d’analyses non linéaires pour appréhender l’effet de l’âge sur la microcirculation sanguine.” 2017. Web. 25 Feb 2021.

Vancouver:

Khalil A. Processing of laser speckle contrast images : study of mathematical models and use of nonlinear analyses to investigate the impact of aging on microvascular blood flow : Traitement d’images de speckle laser : étude à partir de modèles mathématiques et utilisation d’analyses non linéaires pour appréhender l’effet de l’âge sur la microcirculation sanguine. [Internet] [Doctoral dissertation]. Angers; 2017. [cited 2021 Feb 25]. Available from: http://www.theses.fr/2017ANGE0006.

Council of Science Editors:

Khalil A. Processing of laser speckle contrast images : study of mathematical models and use of nonlinear analyses to investigate the impact of aging on microvascular blood flow : Traitement d’images de speckle laser : étude à partir de modèles mathématiques et utilisation d’analyses non linéaires pour appréhender l’effet de l’âge sur la microcirculation sanguine. [Doctoral Dissertation]. Angers; 2017. Available from: http://www.theses.fr/2017ANGE0006

Iowa State University

5. Kim, Jahyun. Repeated remote ischemic preconditioning and cutaneous microvascular responses.

Degree: 2020, Iowa State University

URL: https://lib.dr.iastate.edu/etd/18012

► Remote ischemic preconditioning (RIPC), induced by intermittent periods of sublethal ischemia and reperfusion, may be a practical, non-invasive intervention to confer protection from ischemia-reperfusion (IR)… (more)

▼ Remote ischemic preconditioning (RIPC), induced by intermittent periods of sublethal ischemia and reperfusion, may be a practical, non-invasive intervention to confer protection from ischemia-reperfusion (IR) injury. Early animal studies reliably demonstrate that prior RIPC attenuates infarct size about 23% compared to IR injury group without RIPC. Since infarct size attenuation from 20% to 12% is associated with lowered mortality, RIPC may provide clinical benefits to patients with high cardiovascular disease (CVD) risks. However, recent large clinical studies in humans found inconsistent results with respect to RIPC eliciting cardioprotection or improving clinical outcomes. These disparate results may be explained by the use of propofol as the anesthetic, coexisting conditions (e.g., diabetes, obesity, and hypertension), and other factors (e.g., medications, age, and RIPC protocol). Thus, an experimental model that is able to control for these factors is needed in order to elucidate the underlying protective mechanisms of RIPC as it applies to humans. In vivo experimental models capable of examining mechanisms of myocardial function in humans are limited. As an alternative, the cutaneous circulation is an accessible microvascular bed to non-invasively test human microvascular function in vivo. Skin microvascular function is a good indicator of global microvascular function because functional changes that evolve here parallel other circulations including the coronary microvasculature. A series of studies in the Department of Kinesiology Hemodynamics Laboratory have tested the effects of RIPC on skin microvascular function. We found that maximum vasodilatory capacity increased after seven consecutive days of RIPC; however, we did not observe an improvement in NO-mediated vasodilation. In a follow-up study, we found that one and two weeks of RIPC improved endothelial dependent vasodilation. However, the amount of skin microvascular improvement was not different between these seven consecutive days and two weeks of RIPC. Whether shorter periods of RIPC (i.e., less than 7 days) elicits similar functional improvements is unknown. The effects of a single bout of RIPC are thought to exhibit a two-phase response, an initial (lasting ~4 hours) and a delayed window of protection (lasting 3-4 days). Therefore, different frequencies of RIPC training may stimulate protective pathways differently. Thus, there may be an optimal frequency and duration of RIPC that induces prolonged improvements in microvascular responsivity without long intervention periods. It is important from a clinical standpoint to know the threshold dose needed to elicit beneficial effects of an intervention. This type of information will be useful in optimizing an RIPC-based intervention protocol aimed at improving microvascular function. Thus, the purpose of this study is to assess the extent to which shorter intervention periods (3 days of RIPC separated by rest days; 3QOD RIPC) elicit sustained skin microvascular functional alterations. Our hypothesis…

Subjects/Keywords: Endothelial function; Iontophoresis; laser speckle contrast imaging; Local heating; Skin blood flow; Vascular adaptation

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APA (6^th Edition):

Kim, J. (2020). Repeated remote ischemic preconditioning and cutaneous microvascular responses. (Thesis). Iowa State University. Retrieved from https://lib.dr.iastate.edu/etd/18012

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Kim, Jahyun. “Repeated remote ischemic preconditioning and cutaneous microvascular responses.” 2020. Thesis, Iowa State University. Accessed February 25, 2021. https://lib.dr.iastate.edu/etd/18012.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Kim, Jahyun. “Repeated remote ischemic preconditioning and cutaneous microvascular responses.” 2020. Web. 25 Feb 2021.

Vancouver:

Kim J. Repeated remote ischemic preconditioning and cutaneous microvascular responses. [Internet] [Thesis]. Iowa State University; 2020. [cited 2021 Feb 25]. Available from: https://lib.dr.iastate.edu/etd/18012.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Kim J. Repeated remote ischemic preconditioning and cutaneous microvascular responses. [Thesis]. Iowa State University; 2020. Available from: https://lib.dr.iastate.edu/etd/18012

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Michigan Technological University

6. Khaksari, Kosar. EFFECTS OF SCATTERING AND ABSORPTION ON LASER SPECKLE CONTRAST IMAGING.

Degree: PhD, Department of Biomedical Engineering, 2016, Michigan Technological University

URL: https://digitalcommons.mtu.edu/etdr/181

► Laser Speckle Contrast Imaging (LSCI) is a real-time, non-invasive method in used to investigate blood flow and perfusion in biological tissues with high temporal… (more)

▼ Laser Speckle Contrast Imaging (LSCI) is a real-time, non-invasive method in used to investigate blood flow and perfusion in biological tissues with high temporal and spatial resolution. A reduction in speckle contrast due to particle motion is the primary contrast mechanism in LSCI. Motion results in speckle fluctuations in time and reduces the contrast over a given camera integration period. There are a variety of parameters that effect contrast besides motion. The optical properties of the scattering medium are one of the parameters effecting LSCI values. Changes in blood hematocrit levels manifest as changes in optical properties. In this work, we explore the effects of different hematocrit levels on LSCI contrast values using fluid phantoms with varying optical properties. Herein, the combined effects of scattering and absorption coefficients on LSCI values are investigated using fluid phantoms. These fluid phantoms were designed to mimic the scattering and absorbing properties of blood with varying levels of hematocrit. The flow phantoms in our experiments contained different concentrations of glass microspheres (brand name Luxil) and India ink mixed with DI water. The different number of scatterers and absorbers in the phantoms mimic the scattering and absorption behaviors of blood with different number of red blood cells. An LSCI setup combined with a simple flow system was used in our experiments in order to investigate the effects of combined scattering and absorption coefficient of 121 samples with different concentrations of Luxil and India ink microspheres. The fluid phantoms were run in 2mm glass tubing on top of a plastic block using a mini peristaltic pump. An LSCI setup imaged the flow using a CCD camera. A MATLAB GUI controlled the pump and camera to provide near real-time contrast images of the flow. An 11x11 matrix of phantoms was created. Scattering coefficient was varied on the columns and absorption coefficient was varied on the rows such that the first element of the matrix is water and the last element contains the phantom with the maximum number of scatterers and absorbers. A hundred raw speckle images were recorded for each phantom experiment using the described optical setup. The experiments were conducted 3 times for each element of the matrix. The 11x11 results matrix displayed the average speckle image of all 300 raw speckle images. Additionally, the matrix was filled by the contrast images where contrast was defined as standard deviation of intensity over mean intensity. In order to compare the results numerically, we calculated the ratio of the contrast from the same size window of moving portion over the static portion of the phantoms. According to the results from LSCI experiments, an increase in scattering and absorption coefficients led to a reduction in contrast values of LSCI images. By increasing the number of scatterers and absorbers (equivalent to changing hematocrit level), the optical properties (scattering and absorption coefficient) increased, which led to a… Advisors/Committee Members: Sean J. Kirkpatrick.

Subjects/Keywords: Laser Speckle; Contrast Imaging; Optical Properties; Scattering coefficient; Absorption Coeffcient; Bioimaging and Biomedical Optics

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APA (6^th Edition):

Khaksari, K. (2016). EFFECTS OF SCATTERING AND ABSORPTION ON LASER SPECKLE CONTRAST IMAGING. (Doctoral Dissertation). Michigan Technological University. Retrieved from https://digitalcommons.mtu.edu/etdr/181

Chicago Manual of Style (16^th Edition):

Khaksari, Kosar. “EFFECTS OF SCATTERING AND ABSORPTION ON LASER SPECKLE CONTRAST IMAGING.” 2016. Doctoral Dissertation, Michigan Technological University. Accessed February 25, 2021. https://digitalcommons.mtu.edu/etdr/181.

MLA Handbook (7^th Edition):

Khaksari, Kosar. “EFFECTS OF SCATTERING AND ABSORPTION ON LASER SPECKLE CONTRAST IMAGING.” 2016. Web. 25 Feb 2021.

Vancouver:

Khaksari K. EFFECTS OF SCATTERING AND ABSORPTION ON LASER SPECKLE CONTRAST IMAGING. [Internet] [Doctoral dissertation]. Michigan Technological University; 2016. [cited 2021 Feb 25]. Available from: https://digitalcommons.mtu.edu/etdr/181.

Council of Science Editors:

Khaksari K. EFFECTS OF SCATTERING AND ABSORPTION ON LASER SPECKLE CONTRAST IMAGING. [Doctoral Dissertation]. Michigan Technological University; 2016. Available from: https://digitalcommons.mtu.edu/etdr/181

Michigan Technological University

7. Carrick, Jacob James. INTEGRATION OF INSTRUMENTATION AND PROCESSING SOFTWARE OF A LASER SPECKLE CONTRAST IMAGING SYSTEM.

Degree: MS, Department of Electrical and Computer Engineering, 2014, Michigan Technological University

URL: https://digitalcommons.mtu.edu/etds/774

► Laser speckle contrast imaging (LSCI) has the potential to be a powerful tool in medicine, but more research in the field is required so… (more)

Subjects/Keywords: Contrast; GUI; Imaging; Laser; Speckle; Biomedical Engineering and Bioengineering; Electrical and Computer Engineering; Optics

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APA (6^th Edition):

Carrick, J. J. (2014). INTEGRATION OF INSTRUMENTATION AND PROCESSING SOFTWARE OF A LASER SPECKLE CONTRAST IMAGING SYSTEM. (Masters Thesis). Michigan Technological University. Retrieved from https://digitalcommons.mtu.edu/etds/774

Chicago Manual of Style (16^th Edition):

Carrick, Jacob James. “INTEGRATION OF INSTRUMENTATION AND PROCESSING SOFTWARE OF A LASER SPECKLE CONTRAST IMAGING SYSTEM.” 2014. Masters Thesis, Michigan Technological University. Accessed February 25, 2021. https://digitalcommons.mtu.edu/etds/774.

MLA Handbook (7^th Edition):

Carrick, Jacob James. “INTEGRATION OF INSTRUMENTATION AND PROCESSING SOFTWARE OF A LASER SPECKLE CONTRAST IMAGING SYSTEM.” 2014. Web. 25 Feb 2021.

Vancouver:

Carrick JJ. INTEGRATION OF INSTRUMENTATION AND PROCESSING SOFTWARE OF A LASER SPECKLE CONTRAST IMAGING SYSTEM. [Internet] [Masters thesis]. Michigan Technological University; 2014. [cited 2021 Feb 25]. Available from: https://digitalcommons.mtu.edu/etds/774.

Council of Science Editors:

Carrick JJ. INTEGRATION OF INSTRUMENTATION AND PROCESSING SOFTWARE OF A LASER SPECKLE CONTRAST IMAGING SYSTEM. [Masters Thesis]. Michigan Technological University; 2014. Available from: https://digitalcommons.mtu.edu/etds/774

8. Gaillard-Bigot, Florence. Approches physiopathologiques et pharmacologiques de la fonction microvasculaire dans la Sclérodermie systémique : Physiopathological, pharmacological and therapeutic approaches of cutaneous microcirculation.

Degree: Docteur es, BIS - Biotechnologie, instrumentation, signal et imagerie pour la biologie, la médecine et l'environnement, 2017, Université Grenoble Alpes (ComUE)

URL: http://www.theses.fr/2017GREAS032

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La microcirculation cutanée a été proposée comme modèle d’étude de la dysfonction microvasculaire globale dans les maladies cardiovasculaires. Par ailleurs, elle est spécifiquement atteinte dans… (more)

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La microcirculation cutanée a été proposée comme modèle d’étude de la dysfonction microvasculaire globale dans les maladies cardiovasculaires. Par ailleurs, elle est spécifiquement atteinte dans la sclérodermie systémique (SSc), qui est une maladie dysimmunitaire rare, particulièrement invalidante, caractérisée par une fibrose cutanée et viscérale associée à une atteinte microvasculaire diffuse et la présence d’auto anticorps dirigés contre des antigènes cellulaires. L’exploration de la fonction microvasculaire cutanée suscite donc un réel intérêt, même s’il n’existe pas de technique standardisée pour l’étude de la fonction microvasculaire, en particulier endothéliale.La première partie de ce travail a porté sur l’étude physiologique de la microcirculation cutanée chez le volontaire sain, en utilisant les méthodes les plus récentes adaptées à l’étude fonctionnelle de la microcirculation (tests de réactivité vasculaire couplés à l’enregistrement du flux sanguin cutané par laser speckle contrast imaging). Dans une seconde partie, nous avons étudié la pathologie de la microcirculation cutanée dans la sclérodermie systémique, en utilisant les mêmes d’étude fonctionnelle de la microcirculation. La dernière partie de cette thèse a été consacrée à l’étude d’une nouvelle approche pharmacologique et thérapeutique dans la prise en charge des manifestations vasculaires cutanées périphériques identifiées chez les patients. Nous avons évalué l’effet vasodilatateur du tréprostinil, analogue de la prostacycline, sur le flux sanguin cutané de divers zones anatomiques, chez le volontaire sain, le patient atteint de SSc, le patient diabétique et lors d’un refroidissement local dans la SSc.

Cutaneous microcirculation has been proposed as a model to study the global microvascular dysfunction occurring in cardiovascular diseases. Furthermore, it is specifically impaired in systemic sclerosis (SSc), which is a rare and particularly invalidating auto-immune disease, characterized by a cutaneous and visceral fibrosis, associated with a diffuse microvascular impairment and auto-antibodies targeting some cellular antigens. The study of cutaneous microvascular function provides a real interest despite the lack of available standardized techniques, particularly to explore endothelial microvascular function.In the first part of this work, we aimed to study the physiology of cutaneous microcirculation in healthy volunteers, using the more recent methods in this field, adapted to functional study of microcirculation (vascular reactivity tests coupled with cutaneous blood flow recording by laser speckle contrast imaging). The second part of our work aimed to study the pathology of cutaneous microcirculation in SSc volunteers, by using the same functional exploration methods. The last part of this work has been dedicated to a new pharmacologic and therapeutic approach for the management of peripheral cutaneous vascular manifestations in patients, using innovating technics as cutaneous iontophoresis. We studied the vasodilator effect of…

Advisors/Committee Members: Cracowski, Jean-Luc (thesis director).

Subjects/Keywords: Microcirculation; Flux sanguin cutané; Sclérodermie systémique; Laser speckel contrast imaging; Tréprostinil; Iontophorèse; Microcirculation; Skin blood flow; Systemic sclerosis; Laser speckle contrast imaging; Treprostinil; Iontophoresis; 610

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APA (6^th Edition):

Gaillard-Bigot, F. (2017). Approches physiopathologiques et pharmacologiques de la fonction microvasculaire dans la Sclérodermie systémique : Physiopathological, pharmacological and therapeutic approaches of cutaneous microcirculation. (Doctoral Dissertation). Université Grenoble Alpes (ComUE). Retrieved from http://www.theses.fr/2017GREAS032

Chicago Manual of Style (16^th Edition):

Gaillard-Bigot, Florence. “Approches physiopathologiques et pharmacologiques de la fonction microvasculaire dans la Sclérodermie systémique : Physiopathological, pharmacological and therapeutic approaches of cutaneous microcirculation.” 2017. Doctoral Dissertation, Université Grenoble Alpes (ComUE). Accessed February 25, 2021. http://www.theses.fr/2017GREAS032.

MLA Handbook (7^th Edition):

Gaillard-Bigot, Florence. “Approches physiopathologiques et pharmacologiques de la fonction microvasculaire dans la Sclérodermie systémique : Physiopathological, pharmacological and therapeutic approaches of cutaneous microcirculation.” 2017. Web. 25 Feb 2021.

Vancouver:

Gaillard-Bigot F. Approches physiopathologiques et pharmacologiques de la fonction microvasculaire dans la Sclérodermie systémique : Physiopathological, pharmacological and therapeutic approaches of cutaneous microcirculation. [Internet] [Doctoral dissertation]. Université Grenoble Alpes (ComUE); 2017. [cited 2021 Feb 25]. Available from: http://www.theses.fr/2017GREAS032.

Council of Science Editors:

Gaillard-Bigot F. Approches physiopathologiques et pharmacologiques de la fonction microvasculaire dans la Sclérodermie systémique : Physiopathological, pharmacological and therapeutic approaches of cutaneous microcirculation. [Doctoral Dissertation]. Université Grenoble Alpes (ComUE); 2017. Available from: http://www.theses.fr/2017GREAS032

Freie Universität Berlin

9. Müller, Marc Michael. Laser Speckle Imaging for continuous intraoperative monitoring of cerebral blood flow.

Degree: 2014, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-11195

► Current intraoperative monitoring techniques of cortical perfusion like Laser Doppler are restricted in either spatial or temporal resolution. Laser Speckle Imaging is an optical method,… (more)

▼ Current intraoperative monitoring techniques of cortical perfusion like Laser Doppler are restricted in either spatial or temporal resolution. Laser Speckle Imaging is an optical method, which is already used in different clinical and research settings for non-invasive and direct assessment of cortical perfusion. The purpose of this study was to establish positive and negative prediction rates for specific perfusion thresholds of infarcted and non- infarcted tissue in the human brain. In 22 patients undergoing decompressive craniectomy for treatment of malignant hemispheric stroke Laser Speckle measurements were performed and merged with a magnet resonance imaging reconstruction of the cortical surface including the infarcted cortical tissue. Laser Speckle Imaging-specific relative cortical perfusion was calculated within the infarcted and non-infarcted area defined trough MRI. Laser Speckle Imaging-specific perfusion values (given in the arbitrary unit flux) were normalized to the mean flux in the non-infarcted area. Cumulative probability curves were computed and positive (at least 95% probability of infarction) and negative (at least 95% probability of non-infarction) prediction limits were determined. Laser Speckle Imaging permitted immediate real-time visualization and measurement of relative cortical perfusion in excellent image quality and high spatial-temporal resolution in all patients. Positive and negative prediction limits of infracted tissue were determined at 40% and 110% of baseline perfusion, respectively. Of the exposed cortical surface area across all patients, 61.7±24% were determined as infracted (below 40% normalized flux) compared to 11.2±9% as non-infarcted (above 110% normalized flux) and 27.2±16% as tissue with perfusion between the determined perfusion thresholds of 40 and 110% normalized flux. Laser Speckle Imaging is a valuable tool to sensitively predict infarcted and non-infarcted tissue in patients undergoing neurosurgical procedures due to malignant hemispheric stroke. Laser Speckle Imaging provides excellent spatial resolution and could routinely be used for intraoperative evaluation of hyper- or hypoperfusion during vascular procedures or while positioning multimodal probes for perioperative monitoring. Advisors/Committee Members: m (gender), N.N. (firstReferee), N.N. (furtherReferee).

Subjects/Keywords: Laser Speckle Imaging; Laser Speckle Contrast Analysis; blood flow velocity; malignant stroke; cerebral blood flow; 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Müller, M. M. (2014). Laser Speckle Imaging for continuous intraoperative monitoring of cerebral blood flow. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-11195

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Müller, Marc Michael. “Laser Speckle Imaging for continuous intraoperative monitoring of cerebral blood flow.” 2014. Thesis, Freie Universität Berlin. Accessed February 25, 2021. http://dx.doi.org/10.17169/refubium-11195.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Müller, Marc Michael. “Laser Speckle Imaging for continuous intraoperative monitoring of cerebral blood flow.” 2014. Web. 25 Feb 2021.

Vancouver:

Müller MM. Laser Speckle Imaging for continuous intraoperative monitoring of cerebral blood flow. [Internet] [Thesis]. Freie Universität Berlin; 2014. [cited 2021 Feb 25]. Available from: http://dx.doi.org/10.17169/refubium-11195.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Müller MM. Laser Speckle Imaging for continuous intraoperative monitoring of cerebral blood flow. [Thesis]. Freie Universität Berlin; 2014. Available from: http://dx.doi.org/10.17169/refubium-11195

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Brno University of Technology

10. Hoštáková, Nina. Detekce průtoku pomocí optických interferenčních metod: Flow detection using optical intereference methods.

Degree: 2019, Brno University of Technology

URL: http://hdl.handle.net/11012/38975

► The thesis deals with LSCI (Laser Speckle Contrast Imaging), an optical method utilizing laser speckle contrast for the estimation of blood flow changes. LSCI is… (more)

Subjects/Keywords: laserové spekle; speklový kontrast; zobrazovanie prietoku krvi; optické interferenčné metódy; fantómy biologických tkanív; laser speckle; speckle contrast; blood flow imaging; optical interference methods; biological tissue phantoms

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APA (6^th Edition):

Hoštáková, N. (2019). Detekce průtoku pomocí optických interferenčních metod: Flow detection using optical intereference methods. (Thesis). Brno University of Technology. Retrieved from http://hdl.handle.net/11012/38975

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Hoštáková, Nina. “Detekce průtoku pomocí optických interferenčních metod: Flow detection using optical intereference methods.” 2019. Thesis, Brno University of Technology. Accessed February 25, 2021. http://hdl.handle.net/11012/38975.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Hoštáková, Nina. “Detekce průtoku pomocí optických interferenčních metod: Flow detection using optical intereference methods.” 2019. Web. 25 Feb 2021.

Vancouver:

Hoštáková N. Detekce průtoku pomocí optických interferenčních metod: Flow detection using optical intereference methods. [Internet] [Thesis]. Brno University of Technology; 2019. [cited 2021 Feb 25]. Available from: http://hdl.handle.net/11012/38975.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Hoštáková N. Detekce průtoku pomocí optických interferenčních metod: Flow detection using optical intereference methods. [Thesis]. Brno University of Technology; 2019. Available from: http://hdl.handle.net/11012/38975

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Lund

11. Nilsson, Jan. Liver tissue characterization and influence of chemotherapy in liver surgery.

Degree: 2017, University of Lund

URL: https://lup.lub.lu.se/record/3765fb92-5681-4506-9f8e-8ae17420329b ; https://portal.research.lu.se/ws/files/25698568/e_spik_Jan_Nilsson.pdf

► Background & Aims: Primary liver cancer is the second most common cause of death from cancer worldwide. In the western world, the majority of liver… (more)

▼ Background & Aims: Primary liver cancer is the second most common cause of death from cancer worldwide. In the western world, the majority of liver malignancies consist of colorectal metastases. Liver resection is the primary treatment for cure in liver tumor disease. Hepatic injuries such as steatosis, steatohepatitis, fibrosis and sinusoidal obstruction syndrome, which could be a consequence of chronic liver disease and preoperative chemotherapy treatment, has negative impact on liver surgery. There is a need for an intraoperative tool for identification and quantification of these forms of liver damage. The general aim of this thesis was to evaluate methods for intraoperative liver parenchyma characterization and investigate if liver damage could be detected with these methods. In addition, the influence of chemotherapy on liver regeneration and incisional hernia incidence was investigated. Patients & methods: In study I, intraoperative sidestream dark-field imaging microcirculation measurements were performed on 40 patients before and after liver resection. In study II, intraoperative laser speckle contrast imaging measurements of liver microcirculation were performed on 10 patients. In study III, ex vivo diffuse reflectance spectroscopy measurements on excised liver tissue from 18 patients were performed. In study IV, intraoperative surface diffuse reflectance spectroscopy measurements were performed on 40 liver tumor patients. In study V, radiological liver volume measurements on 74 patients operated with a major liver resection were performed. In study VI, 256 patients’ computed tomography scans were reviewed for the presence of incisional hernia. Results & Conclusions: Liver resection leads to an increase in red blood cell velocity in the sinusoids. Patients with liver parenchymal damage have higher red blood cell velocity, lesser functional sinusoidal density and larger sinusoidal diameter. Laser speckle contrast imaging can potentially be used to achieve non-contact intraoperative hepatic microcirculation measurements but problems with movement artifacts need to be resolved. Surface diffuse reflectance spectroscopy measurements are descriptive for the entire liver and it is possible to perform measurements across the liver capsule. Liver surface diffuse reflectance spectroscopy measurements enable intraoperative steatosis grade evaluation with explicit distinction between mild-to-moderate and moderate-to-severe steatosis. Volume regeneration after a major liver resection is negatively affected by preoperative chemotherapy treatment in patients with colorectal liver metastases. The time interval between the ending of chemotherapy and operation is crucial for the power of this impact. Incisional hernia location after an extended right subcostal incision is almost exclusively in the midline. Risk factors for incisional hernia are prolonged preoperative chemotherapy, preoperative bevacizumab, and previous incisional hernia.

Subjects/Keywords: Surgery; colorectal liver metastases; liver regeneration; incisional hernia; steatosis; hepatic microcirculation; diffuse reflectance spectroscopy; DRS; sidestream dark-field imaging; SDF; laser speckle contrast imaging; LSCI

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Nilsson, J. (2017). Liver tissue characterization and influence of chemotherapy in liver surgery. (Doctoral Dissertation). University of Lund. Retrieved from https://lup.lub.lu.se/record/3765fb92-5681-4506-9f8e-8ae17420329b ; https://portal.research.lu.se/ws/files/25698568/e_spik_Jan_Nilsson.pdf

Chicago Manual of Style (16^th Edition):

Nilsson, Jan. “Liver tissue characterization and influence of chemotherapy in liver surgery.” 2017. Doctoral Dissertation, University of Lund. Accessed February 25, 2021. https://lup.lub.lu.se/record/3765fb92-5681-4506-9f8e-8ae17420329b ; https://portal.research.lu.se/ws/files/25698568/e_spik_Jan_Nilsson.pdf.

MLA Handbook (7^th Edition):

Nilsson, Jan. “Liver tissue characterization and influence of chemotherapy in liver surgery.” 2017. Web. 25 Feb 2021.

Vancouver:

Nilsson J. Liver tissue characterization and influence of chemotherapy in liver surgery. [Internet] [Doctoral dissertation]. University of Lund; 2017. [cited 2021 Feb 25]. Available from: https://lup.lub.lu.se/record/3765fb92-5681-4506-9f8e-8ae17420329b ; https://portal.research.lu.se/ws/files/25698568/e_spik_Jan_Nilsson.pdf.

Council of Science Editors:

Nilsson J. Liver tissue characterization and influence of chemotherapy in liver surgery. [Doctoral Dissertation]. University of Lund; 2017. Available from: https://lup.lub.lu.se/record/3765fb92-5681-4506-9f8e-8ae17420329b ; https://portal.research.lu.se/ws/files/25698568/e_spik_Jan_Nilsson.pdf

University of Wisconsin – Milwaukee

12. Chen, Rex Chin-Hao. Spectral and Temporal Interrogation of Cerebral Hemodynamics Via High Speed Laser Speckle Contrast Imaging.

Degree: MS, Engineering, 2015, University of Wisconsin – Milwaukee

URL: https://dc.uwm.edu/etd/1098

► Laser Speckle Contrast Imaging (LSCI) is a non-scanning wide field-of-view optical imaging technique specifically developed for cerebral blood flow (CBF) monitoring. In this project,… (more)

▼ Laser Speckle Contrast Imaging (LSCI) is a non-scanning wide field-of-view optical imaging technique specifically developed for cerebral blood flow (CBF) monitoring. In this project, a versatile Laser speckle contrast imaging system has been designed and developed to monitor CBF changes and examine the physical properties of cerebral vasculature during functional brain activation experiments. The hardware of the system consists of a high speed CMOS camera, a coherent light source, a trinocular microscope, and a PC that does camera controlling and data storage. The simplicity of the system’s hardware makes it suitable for biological experiments. In controlled flow experiments using a custom made microfluidic channel, the linearity of the CBF estimates was evaluated under high speed imaging settings. Under the camera exposure time setting in the range of tens of micro-seconds, results show a linear relationship between the CBF estimates and the flow rates within the microchannel. This validation permitted LSCI to be used in high frame rate imaging and the method is only limited by the camera speed. In an in vivo experiment, the amount of oxygen intake via breathing by a rat was reduced to 12% to induce the dilation of the vessels. Results demonstrated a positive correlation between the system’s CBF estimates and the pulse wave velocity derived from aortic blood pressure. To exemplify the instantaneous pulsatility flow study acquired at high sampling rate, a pulsatile cerebral blood flow analysis was conducted on two vessels, an arteriole and a venule. The pulsatile waveform results, captured under sampling rate close to 2000 Hz. The pulse of the arteriole rises 13ms faster than the pulse of the venule, and it takes 6ms longer for the pulse of the arteriole to fall below the lower fall-time boundary. By using the second order derivative (accelerated) CBF estimates, the vascular stiffness was evaluated. Results show the arteriole and the venule have increased-vascular-stiffness indices of 0.95 and 0.74. On the other side, the arteriole and the venule have decreased-vascular-stiffness indices of 0.125 and 0.35. Both vascular stiffness indices suggested that the wall of arteriole is more rigid than the venule. The proposed LSCI system can monitor the mean flow over function activation experiment, and the interrogation of blood flow in terms of physiological oscillations. The proposed vascular stiffness metrics for estimating the stroke preliminary symptom, may eventually lead to insights of stroke and its causes. Advisors/Committee Members: Ramin Pashaie.

Subjects/Keywords: Blood Flow Pulse Wave Analysis; Cerebral Blood Flow Monitoring; High Speed Laser Speckle Contrast Imaging; Vascular Stiffness Index; Bioimaging and Biomedical Optics; Biomedical Engineering and Bioengineering; Electrical and Electronics

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Chen, R. C. (2015). Spectral and Temporal Interrogation of Cerebral Hemodynamics Via High Speed Laser Speckle Contrast Imaging. (Thesis). University of Wisconsin – Milwaukee. Retrieved from https://dc.uwm.edu/etd/1098

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Chen, Rex Chin-Hao. “Spectral and Temporal Interrogation of Cerebral Hemodynamics Via High Speed Laser Speckle Contrast Imaging.” 2015. Thesis, University of Wisconsin – Milwaukee. Accessed February 25, 2021. https://dc.uwm.edu/etd/1098.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Chen, Rex Chin-Hao. “Spectral and Temporal Interrogation of Cerebral Hemodynamics Via High Speed Laser Speckle Contrast Imaging.” 2015. Web. 25 Feb 2021.

Vancouver:

Chen RC. Spectral and Temporal Interrogation of Cerebral Hemodynamics Via High Speed Laser Speckle Contrast Imaging. [Internet] [Thesis]. University of Wisconsin – Milwaukee; 2015. [cited 2021 Feb 25]. Available from: https://dc.uwm.edu/etd/1098.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Chen RC. Spectral and Temporal Interrogation of Cerebral Hemodynamics Via High Speed Laser Speckle Contrast Imaging. [Thesis]. University of Wisconsin – Milwaukee; 2015. Available from: https://dc.uwm.edu/etd/1098

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universidade do Estado do Rio de Janeiro

13. Alessandra Saldanha Matheus Fernandes da Costa. Análise da sensibilidade e especificidade da avaliação da microcirculação através do laser speckle contraste por imagem e dos níveis de biomarcadores de disfunção endotelial com base no Endo-PAT em pacientes com Diabetes tipo 1.

Degree: PhD, 2016, Universidade do Estado do Rio de Janeiro

URL: http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=11113 ;

► A disfunção endotelial (DE), no Diabetes Mellitus tipo 1 (DM1), aparece como um denominador comum na fisiopatologia das complicações micro e macrovasculares e representa um… (more)

▼ A disfunção endotelial (DE), no Diabetes Mellitus tipo 1 (DM1), aparece como um denominador comum na fisiopatologia das complicações micro e macrovasculares e representa um marcador precoce do risco cardiovascular (RCV). Nossos objetivos foram: determinar a sensibilidade e a especificidade da avaliação da microcirculação através da metodologia do laser speckle contraste por imagem (LSCI) e dos níveis dos biomarcadores (sVCAM-1 e sICAM-1) com base no ponto de corte do índice de hiperemia reativa (RHI) oriundo da tonometria arterial periférica (PAT), que caracterize a DE no DM1 e identificar os parâmetros clínicos, demográficos e laboratoriais associados ao comprometimento da função endotelial, nestes pacientes. Pacientes com DM1 e com idade ≥ 12 anos foram submetidos a um questionário clínico-epidemiológico. Amostras sanguíneas e urinarias foram coletadas para o perfil lipídico, controle glicêmico, níveis de proteína C-reativa e albuminúria. A reatividade vascular foi avaliada no antebraço através da técnica de LSCI no estado basal, durante a hiperemia reativa pós oclusiva (HRPO) e durante a iontoforese de Acetilcolina (ACh) com correntes anódicas crescentes e a PAT foi realizada fornecendo o RHI através do Endo-PAT. As dosagens de sICAM-1 e sVCAM-1 foram realizadas em ensaios multiplex (Tecnologia xMAP). Foram avaliados 189 pacientes, sendo 97 mulheres (51,3 %), idade de 32 13 anos, duração de doença de 16 (6-21) anos e média HbA1c 9.2% (2.2). De acordo com a análise da curva Receiver Operating Characteristics (ROC), o único teste de reatividade microvascular capaz de identificar os pacientes com DE segundo o RHI ≤1,67 foi a AUC da ACh (p=0.002) naqueles pacientes com duração do DM1 inferior a 5 anos. O valor encontrado de 10369 PU apresentou sensibilidade e especificidade de 65% e 87,5%, respectivamente. Nenhum biomarcador foi capaz de detectar a DE segundo o RHI. Na amostra toda, nenhum teste da reatividade vascular foi capaz de detectar o ponto de corte ideal. As principais variáveis correlacionadas com o RHI foram: idade, idade ao diagnóstico, duração do DM1, dose de insulina kg/dia, PAS e glicemia capilar no dia da PAT, A1c, Taxa de Filtraçao Glomerular (TFG) e níveis de PCR. Os níveis de sVCAM-1 foram correlacionados com os níveis de sICAM-1, duração do DM e glicemia capilar e os níveis de sICAM-1 foram correlacionados com TGO e TGP. As principais variáveis correlacionadas com HRPO AUC foram: FC no dia do LSCI, ACh AUC. Nenhuma correlação houve com a ACh AUC. Na avaliação da microcirculação através da vasodilatação endotélio dependente, a ACh com a metodologia do LSCI, nesta amostra estudada, pôde distinguir os pacientes com DE de acordo com o Escore da PAT, apresentando sensibilidade e especificidade de 65 e 87,5%, respectivamente, somente naqueles pacientes com tempo de DM1 inferior a 5 anos com o ponto de corte de 10369 PU, que sugerimos ser o ideal para a população com DM1. Os parâmetros mais correlacionados com a DE foram: idade, idade ao diagnóstico, duração do DM1, dose de insulina… Advisors/Committee Members: Antonio Felipe Sanjuliani, Marilia de Brito Gomes, Roberta Arnoldi Cobas, Sergio Emanuel Kaiser, Melanie Rodacki, Gil Fernando da Costa Mendes de Salles.

Subjects/Keywords: Diabetes Mellitus tipo 1; Risco Cardiovascular; Disfunção Endotelial; Microcirculação; Laser speckle-contraste imagem; Endo-PAT; Type 1 Diabetes Mellitus; Cardiovascular Risk; Endothelial Dysfunction; Microcirculation; Laser speckle-contrast imaging; Endo-PAT; ENDOCRINOLOGIA; Diabetes Mellitus tipo 1; Sistema cardiovascular Doenças Fatores de risco - Teses; Endotélio - Teses; Microcirculação

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Costa, A. S. M. F. d. (2016). Análise da sensibilidade e especificidade da avaliação da microcirculação através do laser speckle contraste por imagem e dos níveis de biomarcadores de disfunção endotelial com base no Endo-PAT em pacientes com Diabetes tipo 1. (Doctoral Dissertation). Universidade do Estado do Rio de Janeiro. Retrieved from http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=11113 ;

Chicago Manual of Style (16^th Edition):

Costa, Alessandra Saldanha Matheus Fernandes da. “Análise da sensibilidade e especificidade da avaliação da microcirculação através do laser speckle contraste por imagem e dos níveis de biomarcadores de disfunção endotelial com base no Endo-PAT em pacientes com Diabetes tipo 1.” 2016. Doctoral Dissertation, Universidade do Estado do Rio de Janeiro. Accessed February 25, 2021. http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=11113 ;.

MLA Handbook (7^th Edition):

Costa, Alessandra Saldanha Matheus Fernandes da. “Análise da sensibilidade e especificidade da avaliação da microcirculação através do laser speckle contraste por imagem e dos níveis de biomarcadores de disfunção endotelial com base no Endo-PAT em pacientes com Diabetes tipo 1.” 2016. Web. 25 Feb 2021.

Vancouver:

Costa ASMFd. Análise da sensibilidade e especificidade da avaliação da microcirculação através do laser speckle contraste por imagem e dos níveis de biomarcadores de disfunção endotelial com base no Endo-PAT em pacientes com Diabetes tipo 1. [Internet] [Doctoral dissertation]. Universidade do Estado do Rio de Janeiro; 2016. [cited 2021 Feb 25]. Available from: http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=11113 ;.

Council of Science Editors:

Costa ASMFd. Análise da sensibilidade e especificidade da avaliação da microcirculação através do laser speckle contraste por imagem e dos níveis de biomarcadores de disfunção endotelial com base no Endo-PAT em pacientes com Diabetes tipo 1. [Doctoral Dissertation]. Universidade do Estado do Rio de Janeiro; 2016. Available from: http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=11113 ;

University of Texas – Austin

14. Parthasarathy, Ashwin Bharadwaj. Quantitative cerebral blood flow measurement with Multi Exposure Speckle Imaging.

Degree: PhD, Biomedical Engineering, 2010, University of Texas – Austin

URL: http://hdl.handle.net/2152/ETD-UT-2010-05-996

► Cerebral blood flow (CBF) measures are central to the investigation of ischemic strokes, spreading depressions, functional and neuronal activation. Laser Speckle Contrast Imaging (LSCI) is… (more)

▼ Cerebral blood flow (CBF) measures are central to the investigation of ischemic strokes, spreading depressions, functional and neuronal activation. Laser Speckle Contrast Imaging (LSCI) is an optical imaging technique that has been used to obtain CBF measures in vivo at high spatial and temporal resolutions, by quantifying the localized spatial blurring of backscattered coherent light induced by blood flow. Despite being widely used for biomedical applications, LSCI's critical limitations such as its tendency to underestimate large flow changes and its inability to accurately estimate CBF through a thinned skull have not been overcome. This dissertation presents a new Multi Exposure Speckle Imaging (MESI) technique that combines a new instrument and mathematical model to overcome these limitations. Additionally, in a pilot clinical study, an adapted neurosurgical microscope was used to obtain intra-operative LSCI images of CBF in humans. The MESI instrument accurately estimates experimental constants by imaging backscattered speckles over a wide range of the camera's exposure durations. The MESI mathematical model helps account for light that has scattered from both static and moving particles. In controlled flow experiments using tissue simulating phantoms, the MESI technique was found to estimate large changes in flow accurately and the estimates of flow changes were found to be unaffected by the presence of static particles in these phantoms. In an in vivo experiment in which the middle cerebral artery in mice was occluded to induce ~100% reduction in CBF, not only was the reduction in CBF accurately estimated by the MESI technique but these estimates of CBF changes were found to be unaffected by the presence of a thinned skull. The validity of statistical models used to derive the MESI mathematical model was confirmed using in vivo dynamic light scattering (DLS) measurements of CBF in mice. The MESI technique's potential to estimate absolute values of CBF in vivo was demonstrated by comparing CBF estimates obtained using the MESI technique to DLS measurements. The MESI technique's ability to measure CBF changes quantitatively through a thinned skull makes it particularly useful in chronic and long term studies leading to the development of better, more accurate stroke models. Advisors/Committee Members: Dunn, Andrew Kenneth, 1970- (advisor), Milner, Thomas (committee member), Tunnell, James (committee member), Emelianov, Stanislav (committee member), Fox, Douglas (committee member).

Subjects/Keywords: Laser Speckle Contrast Imaging; Multi Exposure Speckle Imaging; Optical blood flow measurements; LSCI; MESI; Cerebral blood flow; Ischemic stroke; Speckle spectroscopy; Dynamic Light Scattering; Intra-operative imaging

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Parthasarathy, A. B. (2010). Quantitative cerebral blood flow measurement with Multi Exposure Speckle Imaging. (Doctoral Dissertation). University of Texas – Austin. Retrieved from http://hdl.handle.net/2152/ETD-UT-2010-05-996

Chicago Manual of Style (16^th Edition):

Parthasarathy, Ashwin Bharadwaj. “Quantitative cerebral blood flow measurement with Multi Exposure Speckle Imaging.” 2010. Doctoral Dissertation, University of Texas – Austin. Accessed February 25, 2021. http://hdl.handle.net/2152/ETD-UT-2010-05-996.

MLA Handbook (7^th Edition):

Parthasarathy, Ashwin Bharadwaj. “Quantitative cerebral blood flow measurement with Multi Exposure Speckle Imaging.” 2010. Web. 25 Feb 2021.

Vancouver:

Parthasarathy AB. Quantitative cerebral blood flow measurement with Multi Exposure Speckle Imaging. [Internet] [Doctoral dissertation]. University of Texas – Austin; 2010. [cited 2021 Feb 25]. Available from: http://hdl.handle.net/2152/ETD-UT-2010-05-996.

Council of Science Editors:

Parthasarathy AB. Quantitative cerebral blood flow measurement with Multi Exposure Speckle Imaging. [Doctoral Dissertation]. University of Texas – Austin; 2010. Available from: http://hdl.handle.net/2152/ETD-UT-2010-05-996

15. Dupont, Jan. Imagerie polarimétrique de speckle statique pour l’étude de matériaux et dynamique pour la détection de micro-vascularisation tumorale : Static speckle polarimetric imaging for material study, and dynamic for the detection of tumoral micro-vascularlzation.

Degree: Docteur es, Electromagnétisme et systèmes de haute fréquence, 2017, Toulouse, ISAE

URL: http://www.theses.fr/2017ESAE0002

►

Lors de la diffusion d’une onde électromagnétique sur une surface de rugosité aléatoire ou dans un volume, un champ de speckle, dont les caractéristiques dépendent… (more)

▼

Lors de la diffusion d’une onde électromagnétique sur une surface de rugosité aléatoire ou dans un volume, un champ de speckle, dont les caractéristiques dépendent du diffuseur considéré, se forme. Les diffusions au sein de matériaux impactent l’état de polarisation d’une lumière incidente. Ainsi, la polarisation est un paramètre sensible pour la caractérisation et l’étude de matériaux. Une technique de polarimétrie résolue spatialement, permettant une mesure de précision en champs de speckle, est proposée. Cette technique est utilisée pour étudier l’impact de différents paramètres d’imagerie sur la mesure polarimétrique, notamment les phénomènes de dépolarisation des champs dus au mode d’observation. Un modèle de simulation de champs de speckle polarisés, validé par comparaison avec l'expérimentation pour différents régimes de diffusions, est développé. Par ailleurs, les propriétés dynamiques de l’échantillon peuvent être mesurées par une analyse de contraste du speckle qu’il diffuse. Un dispositif d’imagerie de micro-vascularisation par mesure de contraste de speckle dynamique polarisé est optimisé, puis appliqué à l’étude in-vivo de l’angiogenèse tumorale du mélanome murin, ainsi que l’évolution de la vascularisation après traitement des tumeurs par électrochimiothérapie. Le potentiel de la technique pour la détection et l'étude du mélanome murin, sans contact ni marqueur, est démontré, avec comme perspective la détection et l'étude du mélanome humain, dont l'efficacité reste à être caractérisée pour une utilisation en imagerie biomédicale.

When an electromagnetic wave is scattered by a rough surface or in a volume, a speckle field is observed, with characterlstlcs depending on the consldered scatterer. Multiple scattering in samples immpact the State of polarizatlon of an incident light. Thus, polarization Is a sensitive parameter for material characterization and study. A spatially resolved polarlmetry method, allowing accurate measurements in speckle fields is proposed. That method is used to study the Impact of various parameters on polarimétrie measurements, especially the depolarization phenomenon due to the observation setup. A polarlzed speskle simulation model is proposed, validated by comparison with expérimentation for various scattering régime. Besides, dynamlc properties of samples can be measured by an analysis of the scattered speckle contrast. A method allowing microvascularization imaging based on dynamic polarized light scattering imaging is optlmlzed, then applied to in-vivo study of the tumor angiogenesis occuring on murine melanoma, as well as the vascularization évolution after a treatment called electrochemotherapy. Potentlal of the method for non invasive détection and study of the murine melanoma is demonstrated, its efflciency on human melanoma for biomédical applications remaning to be characterized.

Advisors/Committee Members: Golzio, Muriel (thesis director), Orlik, Xavier (thesis director).

Subjects/Keywords: Imagerie polarimétrique; Speckle; Polarimétrie de speckle; Dépolarlsation spatiale; Imagerie biomédicale; Imagerie par contraste de speckle dynamique; Mélanome; Polarimétrie imaging; Speckle; Speckle polarlmetry; Spatial depolarization; Biomédical Imaging; Dynamic speckle contrast imaging; Melanoma; 621

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APA (6^th Edition):

Dupont, J. (2017). Imagerie polarimétrique de speckle statique pour l’étude de matériaux et dynamique pour la détection de micro-vascularisation tumorale : Static speckle polarimetric imaging for material study, and dynamic for the detection of tumoral micro-vascularlzation. (Doctoral Dissertation). Toulouse, ISAE. Retrieved from http://www.theses.fr/2017ESAE0002

Chicago Manual of Style (16^th Edition):

Dupont, Jan. “Imagerie polarimétrique de speckle statique pour l’étude de matériaux et dynamique pour la détection de micro-vascularisation tumorale : Static speckle polarimetric imaging for material study, and dynamic for the detection of tumoral micro-vascularlzation.” 2017. Doctoral Dissertation, Toulouse, ISAE. Accessed February 25, 2021. http://www.theses.fr/2017ESAE0002.

MLA Handbook (7^th Edition):

Dupont, Jan. “Imagerie polarimétrique de speckle statique pour l’étude de matériaux et dynamique pour la détection de micro-vascularisation tumorale : Static speckle polarimetric imaging for material study, and dynamic for the detection of tumoral micro-vascularlzation.” 2017. Web. 25 Feb 2021.

Vancouver:

Dupont J. Imagerie polarimétrique de speckle statique pour l’étude de matériaux et dynamique pour la détection de micro-vascularisation tumorale : Static speckle polarimetric imaging for material study, and dynamic for the detection of tumoral micro-vascularlzation. [Internet] [Doctoral dissertation]. Toulouse, ISAE; 2017. [cited 2021 Feb 25]. Available from: http://www.theses.fr/2017ESAE0002.

Council of Science Editors:

Dupont J. Imagerie polarimétrique de speckle statique pour l’étude de matériaux et dynamique pour la détection de micro-vascularisation tumorale : Static speckle polarimetric imaging for material study, and dynamic for the detection of tumoral micro-vascularlzation. [Doctoral Dissertation]. Toulouse, ISAE; 2017. Available from: http://www.theses.fr/2017ESAE0002

University of Texas – Austin

16. Ponticorvo, Adrien. Novel optical techniques for imaging oxygen and other hemodynamic parameters during physiological events.

Degree: PhD, Biomedical Engineering, 2010, University of Texas – Austin

URL: http://hdl.handle.net/2152/ETD-UT-2010-12-2044

► This dissertation presents the development and use of a novel optical imaging system capable of monitoring changes in blood flow, oxygenated hemoglobin, deoxygenated hemoglobin, and… (more)

▼ This dissertation presents the development and use of a novel optical imaging system capable of monitoring changes in blood flow, oxygenated hemoglobin, deoxygenated hemoglobin, and absolute pO₂ in the brain. There are several imaging modalities capable of monitoring these parameters separately. Laser speckle contrast imaging (LSCI) and multi-spectral reflectance imaging (MSRI) have been used to monitor relative blood flow and hemoglobin changes respectively. Phosphorescence quenching, while not typically used for imaging, is capable of noninvasive measurements of pO₂. Combining these three techniques has led to the development of an imaging system that could ultimately lead to a better understanding of brain physiology. By combining techniques such as LSCI and MSRI, it becomes possible to estimate the cerebral metabolic rate of oxygen (CMRO₂), an important indicator of neuronal function. It is equally important to understand absolute pO₂ levels so that oxygen metabolism can be examined in context. Integrating phosphorescence quenching and a spatial light modulator into the imaging system allowed absolute pO₂ to be simultaneously measured in distinct regions. This new combined system was used to investigate pathophysiological conditions such as cortical spreading depression (CSD) and ischemia. The observed hemodynamic changes associated with these events were largely dictated by baseline oxygen levels and varied significantly in different regions. This finding highlighted the importance of having a system capable of monitoring hemodynamic changes and absolute pO₂ simultaneously while maintaining enough spatial resolution to distinguish the changes in different regions. It was found that animals with low baseline pO₂ were unable to deliver enough oxygen to the brain during events like CSD because of the high metabolic demand. In order for this technique to become more prevalent among researchers, it is essential to make it cost effective and simple to use. This was accomplished by replacing the expensive excitation sources with cheaper light emitting diodes (LEDs) and redesigning the software interface so that it was easier to control the entire device. The final system shows the potential to become a key tool for researchers studying the role of absolute pO₂ and other hemodynamic parameters during pathophysiological conditions such as CSD and ischemia. Advisors/Committee Members: Dunn, Andrew Kenneth, 1970- (advisor), Jones, Theresa (committee member), Ress, David (committee member), Rylander, Grady (committee member), Tunnell, James (committee member).

Subjects/Keywords: Optical imaging; Oxygen tension; Blood flow; Hemoglobin; MSRI; LSCI; Multi-spectral reflectance imaging; Laser speckle contrast imaging

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APA (6^th Edition):

Ponticorvo, A. (2010). Novel optical techniques for imaging oxygen and other hemodynamic parameters during physiological events. (Doctoral Dissertation). University of Texas – Austin. Retrieved from http://hdl.handle.net/2152/ETD-UT-2010-12-2044

Chicago Manual of Style (16^th Edition):

Ponticorvo, Adrien. “Novel optical techniques for imaging oxygen and other hemodynamic parameters during physiological events.” 2010. Doctoral Dissertation, University of Texas – Austin. Accessed February 25, 2021. http://hdl.handle.net/2152/ETD-UT-2010-12-2044.

MLA Handbook (7^th Edition):

Ponticorvo, Adrien. “Novel optical techniques for imaging oxygen and other hemodynamic parameters during physiological events.” 2010. Web. 25 Feb 2021.

Vancouver:

Ponticorvo A. Novel optical techniques for imaging oxygen and other hemodynamic parameters during physiological events. [Internet] [Doctoral dissertation]. University of Texas – Austin; 2010. [cited 2021 Feb 25]. Available from: http://hdl.handle.net/2152/ETD-UT-2010-12-2044.

Council of Science Editors:

Ponticorvo A. Novel optical techniques for imaging oxygen and other hemodynamic parameters during physiological events. [Doctoral Dissertation]. University of Texas – Austin; 2010. Available from: http://hdl.handle.net/2152/ETD-UT-2010-12-2044

University of California – Irvine

17. Farraro, Ryan T. Handheld Laser Speckle Imaging System for Neonatal Blood Flow Imaging.

Degree: Biomedical Engineering, 2015, University of California – Irvine

URL: http://www.escholarship.org/uc/item/0wp4f89c

► Background and Objectives:Although abnormal blood flow is linked to clinical risk of illness in neonates, clinicians typically do not integrate flow measurements into routine monitoring… (more)

▼ Background and Objectives:Although abnormal blood flow is linked to clinical risk of illness in neonates, clinicians typically do not integrate flow measurements into routine monitoring in the neonatal intensive care unit (NICU). We and other research groups have previously demonstrated the ability of Laser Speckle Imaging (LSI) to measure changes in blood flow in both a laboratory and clinical settings. We postulate that LSI, in a clinic-friendly form factor, can provide important hemodynamic information in the NICU. Here, I describe initial efforts to develop a handheld LSI system and deploy it to University of California, Irvine Medical Center NICU.Study Design/Methods:I designed and fabricated a handheld LSI system based on design principles to insure successful implementation into a clinical setting. Using in-vitro tissue phantom systems, I assessed the system performance of handheld LSI versus a traditional mounted configuration. I collected multi-user data (n=7) to assess the variation in flow measurements attributed to user performance. I collected data from two in-vivo occlusion models to demonstrate that the handheld device can detect both qualitative and quantitative changes in blood flow. Finally, I acquired data from an on-going NICU based clinical study (n=30, to date) in which we collected LSI images of abdomen and the heel over a period of several months.Results:I demonstrate that the handheld nature of the device has little effect on the flow measurement sensitivity via a study that was focused on the characterization of tissue simulating phantoms. Flow phantoms were characterized using both bench top and handheld LSI instruments. I show that measurements of flow from these phantoms is not user dependent based on testing using a pool of 7 minimally trained users. I demonstrate that the handheld LSI system measures trends in flow that are similar to those reported previously using bench top LSI systems during in-vivo occlusion models. I observed up to an 83.9% increase in flow index measured in neonates at the abdomen after feeding, while only up to a 16.1% increase was observed in the heel. Lastly, I observed a statistically significant difference between the maximum range of flow index values measured at the abdomen in necrotizing enterocolitis neonates and a healthy population (P=.015).Conclusion:The handheld LSI system can measure changes in blood flow and is minimally sensitive to errors due to handheld motion. Flow changes found in the abdomen warrant further studies to investigate the feasibility of using the LSI to detect compromised intestinal blood flow in neonates. These results suggest that LSI may be capable of providing additional screening for neonates with suspected gut pathology.

Subjects/Keywords: Biomedical engineering; Biophotonics; Handheld; Laser Speckle Imaging; Neonatal Care

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APA (6^th Edition):

Farraro, R. T. (2015). Handheld Laser Speckle Imaging System for Neonatal Blood Flow Imaging. (Thesis). University of California – Irvine. Retrieved from http://www.escholarship.org/uc/item/0wp4f89c

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Farraro, Ryan T. “Handheld Laser Speckle Imaging System for Neonatal Blood Flow Imaging.” 2015. Thesis, University of California – Irvine. Accessed February 25, 2021. http://www.escholarship.org/uc/item/0wp4f89c.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Farraro, Ryan T. “Handheld Laser Speckle Imaging System for Neonatal Blood Flow Imaging.” 2015. Web. 25 Feb 2021.

Vancouver:

Farraro RT. Handheld Laser Speckle Imaging System for Neonatal Blood Flow Imaging. [Internet] [Thesis]. University of California – Irvine; 2015. [cited 2021 Feb 25]. Available from: http://www.escholarship.org/uc/item/0wp4f89c.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Farraro RT. Handheld Laser Speckle Imaging System for Neonatal Blood Flow Imaging. [Thesis]. University of California – Irvine; 2015. Available from: http://www.escholarship.org/uc/item/0wp4f89c

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of California – Irvine

18. Lertsakdadet, Ben. Accounting for Motion Artifact and Optical Property Changes in Laser Speckle Imaging.

Degree: Biomedical Engineering, 2019, University of California – Irvine

URL: http://www.escholarship.org/uc/item/589303w3

► Quantitative characterization of blood flow is important to assess acute physiological health and hemodynamic effects of clinical interventions. A critical need exists for a robust… (more)

▼ Quantitative characterization of blood flow is important to assess acute physiological health and hemodynamic effects of clinical interventions. A critical need exists for a robust device designed to assess blood flow in biomedical applications. Laser Speckle Imaging (LSI) is a wide-field non-invasive optical technique that enables superficial blood flow quantification. A few potential clinical applications of LSI include assessing blood flow during burn patient triaging, quantifying tissue perfusion in a neonatal intensive care unit, and real-time blood flow mapping during surgery. The blood flow information that LSI provides can be helpful for bedside care. However, since LSI systems are highly sensitive to motion, most LSI studies are typically performed using mounted systems. Widespread use of LSI in the clinic has not occurred, in part, due to the bulky form factor and lack of mobility of these systems. Our proposed solution to address the limitations of these mounted systems is a handheld LSI device. Handheld LSI would provide clinicians with objective blood flow measurements in a convenient form factor. However, motion artifact during handheld data acquisition can lead to unreliable and inaccurate blood flow values. Attempts have been made to account for motion artifact noise, but they lack an approach to align (co-register) images. Co-registration is a necessary step prior to the common practice of image averaging to improve the signal-to-noise ratio in producing blood flow maps. Our approach to address both motion artifact and image co-registration for handheld LSI was adding a fiducial marker (FM) into our imaging protocol.We developed a portable, handheld LSI device and a protocol that integrated a FM into the imaging workflow. We automated the processes of sorting frames based on motion artifact and co-registering misaligned images. We compared the performance of the mounted and handheld setups using in vitro flow phantom experiments as a proof-of-concept study. We then demonstrated translation of our imaging protocol into an ongoing in vivo study with a porcine burn wound model.We attempted to further reduce motion artifact by making additional modifications to the handheld LSI device. The modified LSI device was also validated with in vitro flow phantom experiments and in vivo imaging of vessels within a dorsal skinfold window chamber model.In addition to the concerns of motion artifacts for clinical imaging, optical property changes in dynamic wounds or developing tissues may cause inaccuracies in the measured blood flow. We addressed this issue by combining LSI and Spatial Frequency Domain Imaging (SFDI), a non-contact imaging modality used to quantify tissue optical properties, to obtain corrected blood flow values. We then showed the potential errors in blood flow values when optical properties are not properly accounted for in the dynamic wounds of a porcine burn wound model.Collectively, these works demonstrate our attempts at providing a viable alternative for clinical blood flow imaging with…

Subjects/Keywords: Biomedical engineering; Laser Speckle Imaging; Motion Artifact; Optical Property

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Lertsakdadet, B. (2019). Accounting for Motion Artifact and Optical Property Changes in Laser Speckle Imaging. (Thesis). University of California – Irvine. Retrieved from http://www.escholarship.org/uc/item/589303w3

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Lertsakdadet, Ben. “Accounting for Motion Artifact and Optical Property Changes in Laser Speckle Imaging.” 2019. Thesis, University of California – Irvine. Accessed February 25, 2021. http://www.escholarship.org/uc/item/589303w3.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Lertsakdadet, Ben. “Accounting for Motion Artifact and Optical Property Changes in Laser Speckle Imaging.” 2019. Web. 25 Feb 2021.

Vancouver:

Lertsakdadet B. Accounting for Motion Artifact and Optical Property Changes in Laser Speckle Imaging. [Internet] [Thesis]. University of California – Irvine; 2019. [cited 2021 Feb 25]. Available from: http://www.escholarship.org/uc/item/589303w3.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Lertsakdadet B. Accounting for Motion Artifact and Optical Property Changes in Laser Speckle Imaging. [Thesis]. University of California – Irvine; 2019. Available from: http://www.escholarship.org/uc/item/589303w3

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

19. Young, Anthony M. Investigation of Laser Speckle Contrast Imaging's Sensitivity to Flow.

Degree: MS, Physics, 2018, Miami University

URL: http://rave.ohiolink.edu/etdc/view?acc_num=miami153256524246362

► This thesis presents data from a series of experiments that investigate the ability of laser speckle contrast imaging (LSCI) to sense changes in flow in… (more)

Subjects/Keywords: Biomedical Research; Biophysics; Optics; Medical Imaging; Physics; laser speckle; laser speckle contrast imaging; flow imaging; dynamic light scattering; coherence imaging; biomedical imaging; blood flow measurement; flow phantom

…a widefield, non-contact method for flowing imaging known as laser speckle contrast… …laser speckle contrast imaging to be used to detect flow. For this to be accomplished, the… …as spatial laser speckle contrast imaging because it uses the spatial standard deviation… …2.1- Imaging Setup There are three components to a laser speckle contrast imaging setup… …speckle contrast imaging. I first present the theory that explains the formation and statistics…

10 more images…

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APA (6^th Edition):

Young, A. M. (2018). Investigation of Laser Speckle Contrast Imaging's Sensitivity to Flow. (Masters Thesis). Miami University. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=miami153256524246362

Chicago Manual of Style (16^th Edition):

Young, Anthony M. “Investigation of Laser Speckle Contrast Imaging's Sensitivity to Flow.” 2018. Masters Thesis, Miami University. Accessed February 25, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=miami153256524246362.

MLA Handbook (7^th Edition):

Young, Anthony M. “Investigation of Laser Speckle Contrast Imaging's Sensitivity to Flow.” 2018. Web. 25 Feb 2021.

Vancouver:

Young AM. Investigation of Laser Speckle Contrast Imaging's Sensitivity to Flow. [Internet] [Masters thesis]. Miami University; 2018. [cited 2021 Feb 25]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=miami153256524246362.

Council of Science Editors:

Young AM. Investigation of Laser Speckle Contrast Imaging's Sensitivity to Flow. [Masters Thesis]. Miami University; 2018. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=miami153256524246362

University of California – Irvine

20. Moy, Wesley. Alternative Therapies in the Treatment of Port Wine Stain Birthmarks.

Degree: Biomedical Engineering, 2015, University of California – Irvine

URL: http://www.escholarship.org/uc/item/8tx833k3

► Roughly 400,000 children each year are born with port wine stain (PWS) birthmarks, which are skin capillary malformations characterized by a pink-reddish color that develop… (more)

▼ Roughly 400,000 children each year are born with port wine stain (PWS) birthmarks, which are skin capillary malformations characterized by a pink-reddish color that develop into purple nodules if left untreated. While PWS birthmarks can be found anywhere on the body and are typically non-life threatening, a large majority (~90%) present on the head and neck regions and can lead to complications including dental abnormalities and may be associated with capillary malformations in other organs such as the eyes (glaucoma), and brain (seizures). Due to the unsightly nature of PWS, people that have them on exposed areas of skin (face, neck, arm or leg regions) can endure immense psychological and social suffering. The current gold standard treatment for PWS in the US is laser irradiation using the pulsed dye laser (PDL). Treatment of PWS with the PDL has limited efficacy; many patients undergo 15 or more laser treatments without seeing full clearance of the PWS, demonstrating the need to investigate alternative therapies. In my dissertation research, I investigated alternatives to PDL treatment for PWS, including photodynamic therapy (PDT), combined PDT/PDL protocols, and alternative light based treatments. PDT has demonstrated promise towards achieving better treatment outcomes for PWS birthmarks, however, careful selection of treatment parameters is needed to avoid unwanted side effects. I performed preclinical studies of PDT using two photosensitizers, NPe6 and Hemoporfin, to better develop safe treatment parameters. I then investigated a combined PDT/PDL protocol and determined that a synergistic effect exists between the PDT and PDL protocols, illustrating that this combined approach leads to a desired treatment outcome while minimizing side effects. To better understand the PDT treatment mechanisms in skin, I also studied the depth of injury caused by NPe6-mediated PDT in preclinical models and found a direct relationship between depth of vascular injury and light dose administered. Finally, in investigating alternatives to the PDL, I studied the use of intense pulsed light (IPL) and performed a direct comparison study to the PDL. I used computational models to characterize the predicted performance of the IPL and performed experimental studies in preclinical models.

Subjects/Keywords: Biomedical engineering; Dose Response Curve; Laser Speckle Imaging; Photodynamic Therapy; Photothermal Therapy; Pulsed Dye Laser

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APA (6^th Edition):

Moy, W. (2015). Alternative Therapies in the Treatment of Port Wine Stain Birthmarks. (Thesis). University of California – Irvine. Retrieved from http://www.escholarship.org/uc/item/8tx833k3

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Moy, Wesley. “Alternative Therapies in the Treatment of Port Wine Stain Birthmarks.” 2015. Thesis, University of California – Irvine. Accessed February 25, 2021. http://www.escholarship.org/uc/item/8tx833k3.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Moy, Wesley. “Alternative Therapies in the Treatment of Port Wine Stain Birthmarks.” 2015. Web. 25 Feb 2021.

Vancouver:

Moy W. Alternative Therapies in the Treatment of Port Wine Stain Birthmarks. [Internet] [Thesis]. University of California – Irvine; 2015. [cited 2021 Feb 25]. Available from: http://www.escholarship.org/uc/item/8tx833k3.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Moy W. Alternative Therapies in the Treatment of Port Wine Stain Birthmarks. [Thesis]. University of California – Irvine; 2015. Available from: http://www.escholarship.org/uc/item/8tx833k3

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

21. Upadhyay, Debajyoti. Imagerie polarimétrique adaptée en lumière cohérente : Adapted Polarimetric Imaging with Coherent Light.

Degree: Docteur es, Electromagnétisme et systèmes de haute fréquence, 2014, Toulouse, ISAE

URL: http://www.theses.fr/2014ESAE0007

►

Nous proposons dans cette thèse d’étudier une méthode d’imagerie qui s’adapte à la scène étudiée en utilisant des états polarimétriques choisis sur critères physiques pour… (more)

▼

Nous proposons dans cette thèse d’étudier une méthode d’imagerie qui s’adapte à la scène étudiée en utilisant des états polarimétriques choisis sur critères physiques pour optimiser le contraste polarimétrique en 2 zones aux propriétés polarimétriques différentes. En prenant en compte le bruit de Grenaille du détecteur, cette nouvelle technique d’imagerie à 2 canaux nommée APSCI montre un gain en contraste quantifié par la distance de Bhattacharyya pouvant atteindre un facteur 10 par rapport à l’imagerie de Mueller. D’autre part, elle utilise la totalité de l’information polarimétrique de la scène pour générer une seule image au contraste optimum ce qui la rend particulièrement performante pour distinguer deux zones aux propriétés polarimétriques légèrement différentes. La solution analytique complète de ce problème est proposée au chapitre suivant avec des illustrations associées. Le modèle proposé permet, en plus d’une interprétation physique, de quantifier les performances limites de la méthode APSCI en fonction des matrices de Mueller des 2 objets à discerner. Le chapitre suivant est consacré à l’étude des performances de cette méthode soumise au bruit optique de tavelure de cible. Les simulations numériques montrent que les performances de cette méthode en terme de contraste polarimétrique restent relativement robustes et souvent très supérieures à celles obtenues par l’imagerie de Mueller classique. Le dernier chapitre consiste à décrire l’implémentation expérimentale nécessaire à l’adaptation d’un imageur de Mueller en imageur APSCI en vue d’obtenir un imageur hybride Mueller/APSCI. La méthode APSCI nécessite de pouvoir utiliser en émission et en projection lors de la détection.

We propose in this thesis to study and imaging method which is adapted to the scene under investigation by the use of specific polarimetric excitations. The scenes under inversigation have two separate regions with different polarimetric properties. The specific fully polarized state of illumination is found by the physical criteria for oprimizing the polarimetric constrat in two aereas with different polarization properties. Taking into account the Shot noise of the detector, this new 2 channel imaging technique named APSCI, shows a gain in contrast quantified by the Bhattacharyya distance of up to a factor of 10 compared to what is achievable from classical Mueller imagnin. On the other hand, it uses the full polarimetric information of the scene to generate a single image at optimum contrast which makes it particularly effective to distinguish two distinct areas with slightly different polarization properties. The complete analytical solution of this problem is proposed in the next chapter with associated illustrations. The proposed model allows, in addition to a physical interpretation of the imaging problem, to quantify the limits of APSCI method based on evaluated Mueller matrices of the scene. Furthermore the relative performance of APSCI vs Classical Mueller Imaging (CMI) associated to polar decomposition has been studied…

Advisors/Committee Members: Orlik, Xavier (thesis director), Lacot, Éric (thesis director).

Subjects/Keywords: Imagerie; Polarimétrie; Laser; Statistique de bruit optique; Imaging; Polarimetry; Laser; Speckle statistics; 621.382 2

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APA (6^th Edition):

Upadhyay, D. (2014). Imagerie polarimétrique adaptée en lumière cohérente : Adapted Polarimetric Imaging with Coherent Light. (Doctoral Dissertation). Toulouse, ISAE. Retrieved from http://www.theses.fr/2014ESAE0007

Chicago Manual of Style (16^th Edition):

Upadhyay, Debajyoti. “Imagerie polarimétrique adaptée en lumière cohérente : Adapted Polarimetric Imaging with Coherent Light.” 2014. Doctoral Dissertation, Toulouse, ISAE. Accessed February 25, 2021. http://www.theses.fr/2014ESAE0007.

MLA Handbook (7^th Edition):

Upadhyay, Debajyoti. “Imagerie polarimétrique adaptée en lumière cohérente : Adapted Polarimetric Imaging with Coherent Light.” 2014. Web. 25 Feb 2021.

Vancouver:

Upadhyay D. Imagerie polarimétrique adaptée en lumière cohérente : Adapted Polarimetric Imaging with Coherent Light. [Internet] [Doctoral dissertation]. Toulouse, ISAE; 2014. [cited 2021 Feb 25]. Available from: http://www.theses.fr/2014ESAE0007.

Council of Science Editors:

Upadhyay D. Imagerie polarimétrique adaptée en lumière cohérente : Adapted Polarimetric Imaging with Coherent Light. [Doctoral Dissertation]. Toulouse, ISAE; 2014. Available from: http://www.theses.fr/2014ESAE0007

Delft University of Technology

22. Van Hauwermeiren, Amber (author). Studying Ice Nucleation and Freezing Front Propagation with Infrared and Laser Speckle Imaging.

Degree: 2018, Delft University of Technology

URL: http://resolver.tudelft.nl/uuid:9d157356-a942-48b6-9d0a-301e689efc02

► Clear ice formation on aircraft is a large economic and safety problem. The phenomenon, also known as ‘freezing rain’, usually occurs when subcooled rain droplets… (more)

Subjects/Keywords: Anti-icing; Laser Speckle Imaging; Infrared Imaging; Hydrophobic-hydrophilic patterns; Aircraft; Clear ice

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APA (6^th Edition):

Van Hauwermeiren, A. (. (2018). Studying Ice Nucleation and Freezing Front Propagation with Infrared and Laser Speckle Imaging. (Masters Thesis). Delft University of Technology. Retrieved from http://resolver.tudelft.nl/uuid:9d157356-a942-48b6-9d0a-301e689efc02

Chicago Manual of Style (16^th Edition):

Van Hauwermeiren, Amber (author). “Studying Ice Nucleation and Freezing Front Propagation with Infrared and Laser Speckle Imaging.” 2018. Masters Thesis, Delft University of Technology. Accessed February 25, 2021. http://resolver.tudelft.nl/uuid:9d157356-a942-48b6-9d0a-301e689efc02.

MLA Handbook (7^th Edition):

Van Hauwermeiren, Amber (author). “Studying Ice Nucleation and Freezing Front Propagation with Infrared and Laser Speckle Imaging.” 2018. Web. 25 Feb 2021.

Vancouver:

Van Hauwermeiren A(. Studying Ice Nucleation and Freezing Front Propagation with Infrared and Laser Speckle Imaging. [Internet] [Masters thesis]. Delft University of Technology; 2018. [cited 2021 Feb 25]. Available from: http://resolver.tudelft.nl/uuid:9d157356-a942-48b6-9d0a-301e689efc02.

Council of Science Editors:

Van Hauwermeiren A(. Studying Ice Nucleation and Freezing Front Propagation with Infrared and Laser Speckle Imaging. [Masters Thesis]. Delft University of Technology; 2018. Available from: http://resolver.tudelft.nl/uuid:9d157356-a942-48b6-9d0a-301e689efc02

Michigan Technological University

23. Majumdar, Anindya. OPTICAL VORTEX AND POINCARÉ ANALYSIS FOR BIOPHYSICAL DYNAMICS.

Degree: PhD, Department of Biomedical Engineering, 2019, Michigan Technological University

URL: https://digitalcommons.mtu.edu/etdr/815

► Coherent light - such as that from a laser - on interaction with biological tissues, undergoes scattering. This scattered light undergoes interference and the… (more)

▼ Coherent light - such as that from a laser - on interaction with biological tissues, undergoes scattering. This scattered light undergoes interference and the resultant field has randomly added phases and amplitudes. This random interference pattern is known as speckles, and has been the subject of multiple applications, including imaging techniques. These speckle fields inherently contain optical vortices, or phase singularities. These are locations where the intensity (or amplitude) of the interference pattern is zero, and the phase is undefined. In the research presented in this dissertation, dynamic speckle patterns were obtained through computer simulations as well as laboratory setups involving scattering from phantoms and animal tissues. Optical vortices were tracked within these patterns. Novel techniques were applied to relate scattering media dynamics with the temporal evolution of the speckle fields and the optical vortex locations. Parameters, such as optical vortex trail lengths, mobility of optical vortices and charge separation between different types of vortices were introduced and calculated. Mathematical formulations, namely Poincaré descriptors, were employed to analyze the statistics of speckle intensity and optical vortex dynamics. A brief review of the advancements in the understanding and detection of optical vortices is presented. This is followed by the theory behind Poincaré analysis. It is concluded that Poincaré descriptors can be used to characterize the correlation in a data series. Speckle patterns with different dynamic behaviors – such as Brownian and Lorentzian modes of decorrelation between consecutive frames, at varying rates - were studied. It was noted that measuring the optical vortex parameters in a dynamically evolving field, provided insights into the decorrelation characteristics of the scattering medium. As speckle size is a statistical measure of the intensity variation in the field, the use of Poincaré descriptors to estimate speckle size is demonstrated. Additionally, these descriptors differentiate between short- and long-range orders in data. Laser speckle images obtained from flow in fluid phantoms and animal tissues indicated that Poincaré analysis provides an alternate method of quantifying flow. Advisors/Committee Members: Sean J Kirkpatrick.

Subjects/Keywords: Optics; Singular Optics; Optical Vortices; Laser Speckle; Statistics; Imaging; Bioimaging and Biomedical Optics; Optics

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APA (6^th Edition):

Majumdar, A. (2019). OPTICAL VORTEX AND POINCARÉ ANALYSIS FOR BIOPHYSICAL DYNAMICS. (Doctoral Dissertation). Michigan Technological University. Retrieved from https://digitalcommons.mtu.edu/etdr/815

Chicago Manual of Style (16^th Edition):

Majumdar, Anindya. “OPTICAL VORTEX AND POINCARÉ ANALYSIS FOR BIOPHYSICAL DYNAMICS.” 2019. Doctoral Dissertation, Michigan Technological University. Accessed February 25, 2021. https://digitalcommons.mtu.edu/etdr/815.

MLA Handbook (7^th Edition):

Majumdar, Anindya. “OPTICAL VORTEX AND POINCARÉ ANALYSIS FOR BIOPHYSICAL DYNAMICS.” 2019. Web. 25 Feb 2021.

Vancouver:

Majumdar A. OPTICAL VORTEX AND POINCARÉ ANALYSIS FOR BIOPHYSICAL DYNAMICS. [Internet] [Doctoral dissertation]. Michigan Technological University; 2019. [cited 2021 Feb 25]. Available from: https://digitalcommons.mtu.edu/etdr/815.

Council of Science Editors:

Majumdar A. OPTICAL VORTEX AND POINCARÉ ANALYSIS FOR BIOPHYSICAL DYNAMICS. [Doctoral Dissertation]. Michigan Technological University; 2019. Available from: https://digitalcommons.mtu.edu/etdr/815

University of Alberta

24. Ali, Atif. Femtosecond laser based x-ray sources and their applications in phase contrast imaging.

Degree: MS, Department of Electrical and Computer Engineering, 2010, University of Alberta

URL: https://era.library.ualberta.ca/files/7h149q081

► The focus of this dissertation is to study the keV X-ray emission from different Z material to develop compact, quasi-continuous tabletop Kα sources for the… (more)

Subjects/Keywords: Laser plasma interaction, x-rays, phase contrast imaging

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APA (6^th Edition):

Ali, A. (2010). Femtosecond laser based x-ray sources and their applications in phase contrast imaging. (Masters Thesis). University of Alberta. Retrieved from https://era.library.ualberta.ca/files/7h149q081

Chicago Manual of Style (16^th Edition):

Ali, Atif. “Femtosecond laser based x-ray sources and their applications in phase contrast imaging.” 2010. Masters Thesis, University of Alberta. Accessed February 25, 2021. https://era.library.ualberta.ca/files/7h149q081.

MLA Handbook (7^th Edition):

Ali, Atif. “Femtosecond laser based x-ray sources and their applications in phase contrast imaging.” 2010. Web. 25 Feb 2021.

Vancouver:

Ali A. Femtosecond laser based x-ray sources and their applications in phase contrast imaging. [Internet] [Masters thesis]. University of Alberta; 2010. [cited 2021 Feb 25]. Available from: https://era.library.ualberta.ca/files/7h149q081.

Council of Science Editors:

Ali A. Femtosecond laser based x-ray sources and their applications in phase contrast imaging. [Masters Thesis]. University of Alberta; 2010. Available from: https://era.library.ualberta.ca/files/7h149q081

25. Liu, Penghuan. Statistical and numerical optimization for speckle blind structured illumination microscopy : Optimisation numérique et statistique pour la microscopie à éclairement structuré non contrôlé.

Degree: Docteur es, Signal, Image, Vision, 2018, Ecole centrale de Nantes

URL: http://www.theses.fr/2018ECDN0008

►

La microscopie à éclairements structurés(structured illumination microscopy, SIM) permet de dépasser la limite de résolution en microscopie optique due à la diffraction, en éclairant l’objet… (more)

▼

La microscopie à éclairements structurés(structured illumination microscopy, SIM) permet de dépasser la limite de résolution en microscopie optique due à la diffraction, en éclairant l’objet avec un ensemble de motifs périodiques parfaitement connus. Cependant, il s’avère difficile de contrôler exactement la forme des motifs éclairants. Qui plus est, de fortes distorsions de la grille de lumière peuvent être générées par l’échantillon lui-même dans le volume d’étude, ce qui peut provoquer de forts artefacts dans les images reconstruites. Récemment, des approches dites blind-SIM ont été proposées, où les images sont acquises à partir de motifs d’éclairement inconnus, non-périodiques, de type speckle,bien plus faciles à générer en pratique. Le pouvoir de super résolution de ces méthodes a été observé, sans forcément être bien compris théoriquement. Cette thèse présente deux nouvelles méthodes de reconstruction en microscopie à éclairements structurés inconnus (blind speckle-SIM) : une approche conjointe et une approche marginale. Dans l’approche conjointe, nous estimons conjointement l’objet et les motifs d’éclairement au moyen d’un modèle de type Basis Pursuit DeNoising (BPDN) avec une régularisation en norme lp,q où p=>1 et 0<q<=1. La norme lp,q est introduite afin de prendre en compte une hypothèse de parcimonie sur l’objet. Dans l’approche marginale, nous reconstruisons uniquement l’objet et les motifs d’éclairement sont traités comme des paramètres de nuisance. Notre contribution est double. Premièrement, une analyse théorique démontre que l’exploitation des statistiques d’ordre deux des données permet d’accéder à un facteur de super résolution de deux, lorsque le support de la densité spectrale du speckle correspond au support fréquentiel de la fonction de transfert du microscope. Ensuite, nous abordons le problème du calcul numérique de la solution. Afin de réduire à la fois le coût de calcul et les ressources en mémoire, nous proposons un estimateur marginal à base de patches. L’élément clé de cette méthode à patches est de négliger l’information de corrélation entre les pixels appartenant à différents patches. Des résultats de simulations et en application à des données réelles démontrent la capacité de super résolution de nos méthodes. De plus, celles-ci peuvent être appliquées aussi bien sur des problèmes de reconstruction 2D d’échantillons fins, mais également sur des problèmes d’imagerie 3D d’objets plus épais.

Conventional structured illumination microscopy (SIM) can surpass the resolution limit inoptical microscopy caused by the diffraction effect, through illuminating the object with a set of perfectly known harmonic patterns. However, controlling the illumination patterns is a difficult task. Even worse, strongdistortions of the light grid can be induced by the sample within the investigated volume, which may give rise to strong artifacts in SIM reconstructed images. Recently, blind-SIM strategies were proposed, whereimages are acquired through unknown, non-harmonic,speckle illumination patterns,…

Advisors/Committee Members: Idier, Jérôme (thesis director).

Subjects/Keywords: Imagerie super-résolue; Optimisation numérique; Éclairement de speckle; Estimation à minimum de contraste; Parcimonie conjointe; Super-resolution imaging; Numerical optimization; Speckle illumination; Minimum contrast estimation; Joint sparsity

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APA (6^th Edition):

Liu, P. (2018). Statistical and numerical optimization for speckle blind structured illumination microscopy : Optimisation numérique et statistique pour la microscopie à éclairement structuré non contrôlé. (Doctoral Dissertation). Ecole centrale de Nantes. Retrieved from http://www.theses.fr/2018ECDN0008

Chicago Manual of Style (16^th Edition):

Liu, Penghuan. “Statistical and numerical optimization for speckle blind structured illumination microscopy : Optimisation numérique et statistique pour la microscopie à éclairement structuré non contrôlé.” 2018. Doctoral Dissertation, Ecole centrale de Nantes. Accessed February 25, 2021. http://www.theses.fr/2018ECDN0008.

MLA Handbook (7^th Edition):

Liu, Penghuan. “Statistical and numerical optimization for speckle blind structured illumination microscopy : Optimisation numérique et statistique pour la microscopie à éclairement structuré non contrôlé.” 2018. Web. 25 Feb 2021.

Vancouver:

Liu P. Statistical and numerical optimization for speckle blind structured illumination microscopy : Optimisation numérique et statistique pour la microscopie à éclairement structuré non contrôlé. [Internet] [Doctoral dissertation]. Ecole centrale de Nantes; 2018. [cited 2021 Feb 25]. Available from: http://www.theses.fr/2018ECDN0008.

Council of Science Editors:

Liu P. Statistical and numerical optimization for speckle blind structured illumination microscopy : Optimisation numérique et statistique pour la microscopie à éclairement structuré non contrôlé. [Doctoral Dissertation]. Ecole centrale de Nantes; 2018. Available from: http://www.theses.fr/2018ECDN0008

Cal Poly

26. Hinsdale, Taylor A. Laser Speckle Imaging: A Quantitative Tool for Flow Analysis.

Degree: MS, Biomedical and General Engineering, 2014, Cal Poly

URL: https://digitalcommons.calpoly.edu/theses/1251 ; 10.15368/theses.2014.96

► Laser speckle imaging, often referred to as laser speckle contrast analysis (LASCA), has been sought after as a quasi-real-time, full-field, flow visualization method. It… (more)

Subjects/Keywords: Laser; Speckle; Quantitative; Flow; Blood

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APA (6^th Edition):

Hinsdale, T. A. (2014). Laser Speckle Imaging: A Quantitative Tool for Flow Analysis. (Masters Thesis). Cal Poly. Retrieved from https://digitalcommons.calpoly.edu/theses/1251 ; 10.15368/theses.2014.96

Chicago Manual of Style (16^th Edition):

Hinsdale, Taylor A. “Laser Speckle Imaging: A Quantitative Tool for Flow Analysis.” 2014. Masters Thesis, Cal Poly. Accessed February 25, 2021. https://digitalcommons.calpoly.edu/theses/1251 ; 10.15368/theses.2014.96.

MLA Handbook (7^th Edition):

Hinsdale, Taylor A. “Laser Speckle Imaging: A Quantitative Tool for Flow Analysis.” 2014. Web. 25 Feb 2021.

Vancouver:

Hinsdale TA. Laser Speckle Imaging: A Quantitative Tool for Flow Analysis. [Internet] [Masters thesis]. Cal Poly; 2014. [cited 2021 Feb 25]. Available from: https://digitalcommons.calpoly.edu/theses/1251 ; 10.15368/theses.2014.96.

Council of Science Editors:

Hinsdale TA. Laser Speckle Imaging: A Quantitative Tool for Flow Analysis. [Masters Thesis]. Cal Poly; 2014. Available from: https://digitalcommons.calpoly.edu/theses/1251 ; 10.15368/theses.2014.96

Massey University

27. Eccles, Craig David. An investigation of laser speckle using a linear, charge-coupled, photodiode array.

Degree: MS, Physics, 1982, Massey University

URL: http://hdl.handle.net/10179/12772

► This thesis describes the use of a linear, charge-coupled, photodiode array, and microprocessor in the measurement of various laser speckle statistics. Contrast and probability densities… (more)

Subjects/Keywords: Laser speckle

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APA (6^th Edition):

Eccles, C. D. (1982). An investigation of laser speckle using a linear, charge-coupled, photodiode array. (Masters Thesis). Massey University. Retrieved from http://hdl.handle.net/10179/12772

Chicago Manual of Style (16^th Edition):

Eccles, Craig David. “An investigation of laser speckle using a linear, charge-coupled, photodiode array.” 1982. Masters Thesis, Massey University. Accessed February 25, 2021. http://hdl.handle.net/10179/12772.

MLA Handbook (7^th Edition):

Eccles, Craig David. “An investigation of laser speckle using a linear, charge-coupled, photodiode array.” 1982. Web. 25 Feb 2021.

Vancouver:

Eccles CD. An investigation of laser speckle using a linear, charge-coupled, photodiode array. [Internet] [Masters thesis]. Massey University; 1982. [cited 2021 Feb 25]. Available from: http://hdl.handle.net/10179/12772.

Council of Science Editors:

Eccles CD. An investigation of laser speckle using a linear, charge-coupled, photodiode array. [Masters Thesis]. Massey University; 1982. Available from: http://hdl.handle.net/10179/12772

28. Fontenelle, Hugues. Laser speckle imaging : spatio-temporal image enhancement.

Degree: 2010, University of Patras

URL: http://nemertes.lis.upatras.gr/jspui/handle/10889/3378

►

It is well known now that there exists a coupling between functional brain activity and regional blood flow response in the somatosensory cortex and other… (more)

▼

It is well known now that there exists a coupling between functional brain activity and regional blood flow response in the somatosensory cortex and other cortical areas. Various modalities, including functional magnetic resonance imaging and optical imaging (intrinsic signals as well as fluorescence), have been developed in the past to map functional brain activity. The complexity and fundamental physical constraints of the instruments preclude functional imaging in awake, behaving small animals. This thesis presents the method of Laser Speckle Imaging (LSI) of brain with high spatial and temporal resolution, and potential for imaging awake and behaving animals. The method has the potential to map brain activation with high sensitivity and spatiotemporal resolution without using any exogenous contrast agents. In LSI, scattered laser light with different paths produces a random interference pattern known as speckle, fluctuations of which contain information about the motion of particles in the underlying medium. A post-processing step is needed to extract information out of the speckle images, two of which we introduce in details. Our first method is based on Laser speckle contrast analysis (LASCA), which has been demonstrated as a full-field method for imaging the cerebral blood flow (CBF). However, conventional LASCA is limited to extremely low dynamic range because of the ambient background field, dark current and anomalies in the circuits of CCD camera, which makes it difficult to analyze the spatiotemporal variabilities in CBF. In this study, we propose an enhanced laser speckle contrast analysis (eLASCA) method to improve the dynamic range of LASCA based on monotonic point transformation (MPT). In addition, eLASCA greatly improves the CBF visualization, which is very helpful in demonstrating the details of CBF change. Our second method involves the second order features (SOFs) of the image; they are derived from the cooccurrence matrix that in turn was calculated over the same spatial and temporal window than for the contrast. The image quality metrics - equivalent number of looks, entropy and objective quality – showed superior performance of the SOFs comparing to the contrast analysis.

–

Advisors/Committee Members: Μπεζεριάνος, Αναστάσιος, Παναγιωτάκης, Γεώργιος, Παλληκαράκης, Νικόλαος, Κωστόπουλος, Γεώργιος, Μητσάκου, Aδαμαντία, Νικηφορίδης, Γεώργιος, Φωτόπουλος, Σπύρος, Μπεζεριάνος, Αναστάσιος.

Subjects/Keywords: Laser speckle imaging (LSI); Cerebral blood flow; 610.28; Απεικόνιση κοκκίδωσης λέιζερ; Ροή αίματος στον εγκεφαλικό φλοίο

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APA (6^th Edition):

Fontenelle, H. (2010). Laser speckle imaging : spatio-temporal image enhancement. (Doctoral Dissertation). University of Patras. Retrieved from http://nemertes.lis.upatras.gr/jspui/handle/10889/3378

Chicago Manual of Style (16^th Edition):

Fontenelle, Hugues. “Laser speckle imaging : spatio-temporal image enhancement.” 2010. Doctoral Dissertation, University of Patras. Accessed February 25, 2021. http://nemertes.lis.upatras.gr/jspui/handle/10889/3378.

MLA Handbook (7^th Edition):

Fontenelle, Hugues. “Laser speckle imaging : spatio-temporal image enhancement.” 2010. Web. 25 Feb 2021.

Vancouver:

Fontenelle H. Laser speckle imaging : spatio-temporal image enhancement. [Internet] [Doctoral dissertation]. University of Patras; 2010. [cited 2021 Feb 25]. Available from: http://nemertes.lis.upatras.gr/jspui/handle/10889/3378.

Council of Science Editors:

Fontenelle H. Laser speckle imaging : spatio-temporal image enhancement. [Doctoral Dissertation]. University of Patras; 2010. Available from: http://nemertes.lis.upatras.gr/jspui/handle/10889/3378

Freie Universität Berlin

29. Hecht, Nils Nicholas. Cerebral collateral vessel growth and intraoperative Laser Speckle Imaging.

Degree: 2016, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-12780

► Hemodynamic compromise is responsible for ischemic stroke in about 10% of all cases and the endogenous capacity to compensate this chronic cerebral ischemia through outgrowth… (more)

▼ Hemodynamic compromise is responsible for ischemic stroke in about 10% of all cases and the endogenous capacity to compensate this chronic cerebral ischemia through outgrowth of preexisting collaterals is naturally limited. Currently, treatment strategies for surgical augmentation of collateral flow remain hampered by a high perioperative stroke risk or hemodynamic inefficacy. Against this background, the present study investigated the influence of age on chronic cerebral ischemia and strategies for therapeutic stimulation of cerebral collateral vessel growth in a C57BL/6 mouse and Sprague-Dawley rat model of chronic cerebral hypoperfusion. For the first time, we were able to demonstrate that high age is associated with a negative outgrowth of preexisting cerebral collaterals and delayed cerebral hemodynamic rescue, which may explain the increased hemodynamic stroke risk in the elderly. Secondly, a pre-clinical model was used to successfully demonstrate that endothelial progenitor cells may serve as a novel, non-surgical treatment for stimulation of cerebral collateral growth and hemodynamic rescue. Thirdly, an experimental mouse model was developed to investigate the potential of a myoblast-mediated gene therapy in combination with an encephalomyosynangiosis (EMS) as a novel, safe and effective treatment for chronic cerebral ischemia. Here, the effective stimulation of extra- intracranial collateralization demonstrated that myoblast-mediated VEGF growth factor supplementation at the muscle / brain interface of the EMS could help to improve the limited clinical results following indirect surgical EMS revascularization in patients with hemodynamic compromise and insufficient collateralization. The clinical part of the present study focused on the validation of intraoperative Laser Speckle Imaging (iLSI) as a non-invasive tool for continuous monitoring and visualization of cerebral perfusion during neurosurgical procedures. On the basis of patients with the clinical need for direct surgical bypass revascularization and hemodynamically healthy control patients, the general applicability, sensitivity and response dynamics of iLSI for routine measurement and visualization of cortical perfusion were successfully demonstrated. For further validation of the pseudo-quantitative perfusion assessment through iLSI, iLSI-specific perfusion thresholds for reliable prediction and exclusion of cortical infarction were identified, which helped to establish iLSI as a simple, safe and reliable tool for cortical perfusion monitoring in the human brain. Advisors/Committee Members: m (gender), Prof. Dr. med. A. Brawanski (firstReferee), Prof. Dr. med. C. Thomé (furtherReferee).

Subjects/Keywords: collateral vessel growth; arteriogenesis; laser speckle imaging; chronic cerebral ischemia; stroke; 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

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APA (6^th Edition):

Hecht, N. N. (2016). Cerebral collateral vessel growth and intraoperative Laser Speckle Imaging. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-12780

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Hecht, Nils Nicholas. “Cerebral collateral vessel growth and intraoperative Laser Speckle Imaging.” 2016. Thesis, Freie Universität Berlin. Accessed February 25, 2021. http://dx.doi.org/10.17169/refubium-12780.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Hecht, Nils Nicholas. “Cerebral collateral vessel growth and intraoperative Laser Speckle Imaging.” 2016. Web. 25 Feb 2021.

Vancouver:

Hecht NN. Cerebral collateral vessel growth and intraoperative Laser Speckle Imaging. [Internet] [Thesis]. Freie Universität Berlin; 2016. [cited 2021 Feb 25]. Available from: http://dx.doi.org/10.17169/refubium-12780.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Hecht NN. Cerebral collateral vessel growth and intraoperative Laser Speckle Imaging. [Thesis]. Freie Universität Berlin; 2016. Available from: http://dx.doi.org/10.17169/refubium-12780

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Brno University of Technology

30. Byrtus, David. Metoda ‘sledování regionů’ pro analýzu ultrazvukových sekvencí: Region tracking in ultrasound sequences.

Degree: 2014, Brno University of Technology

URL: http://hdl.handle.net/11012/31541

Thesis deals with ultrasonographic contrast examinations, that are performed to assess tissue perfusion and non-invasive ultrasound method speckle tracking, overcoming the weaknesses of Doppler techniques used to scanning the movement of the tissue. Advisors/Committee Members: Slávik, Vladimír (advisor), Harabiš, Vratislav (referee).

Subjects/Keywords: Dopplerův jev; harmonické zobrazení; kontrastní látky; mikrobublina; mechanický index; Spekle tracking; Block-matching; Singhs algoritmus; Doppler; harmonic imaging; contrast agents; microbubbles; mechanical index; Speckle tracking; Block-matching; Singhs algorithm

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APA (6^th Edition):

Byrtus, D. (2014). Metoda ‘sledování regionů’ pro analýzu ultrazvukových sekvencí: Region tracking in ultrasound sequences. (Thesis). Brno University of Technology. Retrieved from http://hdl.handle.net/11012/31541

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Byrtus, David. “Metoda ‘sledování regionů’ pro analýzu ultrazvukových sekvencí: Region tracking in ultrasound sequences.” 2014. Thesis, Brno University of Technology. Accessed February 25, 2021. http://hdl.handle.net/11012/31541.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Byrtus, David. “Metoda ‘sledování regionů’ pro analýzu ultrazvukových sekvencí: Region tracking in ultrasound sequences.” 2014. Web. 25 Feb 2021.

Vancouver:

Byrtus D. Metoda ‘sledování regionů’ pro analýzu ultrazvukových sekvencí: Region tracking in ultrasound sequences. [Internet] [Thesis]. Brno University of Technology; 2014. [cited 2021 Feb 25]. Available from: http://hdl.handle.net/11012/31541.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Byrtus D. Metoda ‘sledování regionů’ pro analýzu ultrazvukových sekvencí: Region tracking in ultrasound sequences. [Thesis]. Brno University of Technology; 2014. Available from: http://hdl.handle.net/11012/31541

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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Open Access Theses and Dissertations