subject:(LDL cholesterol)

University of Ottawa

1. Sarkar, Samantha Khadija. Asociation of PCSK9 with Low Density Lipoproteins (LDL) in the Regulation of LDL-Cholesterol Levels .

Degree: 2015, University of Ottawa

URL: http://hdl.handle.net/10393/32825

► Proprotein Convertase Subtilisin / Kexin Type-9 (PCSK9) has emerged as a major regulator of plasma cholesterol levels. PCSK9 is secreted mainly from the liver and… (more)

▼ Proprotein Convertase Subtilisin / Kexin Type-9 (PCSK9) has emerged as a major regulator of plasma cholesterol levels. PCSK9 is secreted mainly from the liver and circulates as a plasma protein. PCSK9 binds cell surface low-density lipoprotein (LDL) receptors and mediates their degradation upon endocytosis in the liver. This decreases the liver’s ability to clear LDL-cholesterol from the blood. PCSK9 is also capable of binding LDL particles themselves; this interaction inhibits the ability of PCSK9 to bind and mediate LDLR degradation in cultured hepatic cells, but its effect on PCSK9 function in vivo remains unknown. A disordered N-terminal region of the PCSK9 prodomain is necessary for binding to isolated LDL particles in vitro. This N-terminal region is also autoinhibitory to PCSK9-LDL receptor binding. We hypothesized that the N-terminal of the PCSK9 prodomain plays a role in an allosteric mechanism that regulates PCSK9 function. Through mutagenesis studies, we found that both a conserved stretch of acidic residues and an adjacent conserved stretch of hydrophobic residues are crucial for the PCSK9-LDL interaction; the hydrophobicity of the residue at position 38 (Tyr) within the conserved acidic stretch was also found to be important for this. Helical wheel modeling of the prodomain N-terminal sequence revealed the potential for a lipid-ordered amphipathic helix to form, which may aid PCSK9 docking onto LDL. Replacing residues A44 and L41 with helix-disrupting proline residues abolished LDL binding. Co-pelleting ultracentrifugation assays also show that wild-type PCSK9 is capable of associating with liposomes, while the A44P mutation disrupts this lipid association. The A44P-PCSK9 mutation, showing an 80-90% decrease in LDL association but with LDL receptor binding and degrading functions intact, may serve as an important tool in future studies investigating the PCSK9-LDL interaction in vivo. Elucidation of the mechanism by which LDL-binding naturally inhibits PCSK9 activity may also help to develop new anti-PCSK9 therapeutics in the future.

Subjects/Keywords: PCSK9; LDL; lipoprotein; cholesterol

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APA (6^th Edition):

Sarkar, S. K. (2015). Asociation of PCSK9 with Low Density Lipoproteins (LDL) in the Regulation of LDL-Cholesterol Levels . (Thesis). University of Ottawa. Retrieved from http://hdl.handle.net/10393/32825

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Sarkar, Samantha Khadija. “Asociation of PCSK9 with Low Density Lipoproteins (LDL) in the Regulation of LDL-Cholesterol Levels .” 2015. Thesis, University of Ottawa. Accessed January 23, 2021. http://hdl.handle.net/10393/32825.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Sarkar, Samantha Khadija. “Asociation of PCSK9 with Low Density Lipoproteins (LDL) in the Regulation of LDL-Cholesterol Levels .” 2015. Web. 23 Jan 2021.

Vancouver:

Sarkar SK. Asociation of PCSK9 with Low Density Lipoproteins (LDL) in the Regulation of LDL-Cholesterol Levels . [Internet] [Thesis]. University of Ottawa; 2015. [cited 2021 Jan 23]. Available from: http://hdl.handle.net/10393/32825.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Sarkar SK. Asociation of PCSK9 with Low Density Lipoproteins (LDL) in the Regulation of LDL-Cholesterol Levels . [Thesis]. University of Ottawa; 2015. Available from: http://hdl.handle.net/10393/32825

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

2. Miyazawa, Haruna. Increased serum PCSK9 concentrations are associated with periodontal infection but do not correlate with LDL cholesterol concentration : 血清PCSK9レベルの上昇は歯周炎罹患と関連するが、LDLコレステロールレベルとは相関しない.

Degree: 博士（歯学）, 2014, Niigata University / 新潟大学

URL: http://hdl.handle.net/10191/27391

学位の種類: 博士（歯学）. 報告番号: 甲第3878号. 学位記番号: 新大院博（歯）甲第297号. 学位授与年月日: 平成26年3月24日

Clinica Chimica Acta. 2012, 413(1-2), 154-159

Subjects/Keywords: PCSK9; LDL cholesterol; Periodontitis; Chronic inflammation

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APA (6^th Edition):

Miyazawa, H. (2014). Increased serum PCSK9 concentrations are associated with periodontal infection but do not correlate with LDL cholesterol concentration : 血清PCSK9レベルの上昇は歯周炎罹患と関連するが、LDLコレステロールレベルとは相関しない. (Thesis). Niigata University / 新潟大学. Retrieved from http://hdl.handle.net/10191/27391

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Miyazawa, Haruna. “Increased serum PCSK9 concentrations are associated with periodontal infection but do not correlate with LDL cholesterol concentration : 血清PCSK9レベルの上昇は歯周炎罹患と関連するが、LDLコレステロールレベルとは相関しない.” 2014. Thesis, Niigata University / 新潟大学. Accessed January 23, 2021. http://hdl.handle.net/10191/27391.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Miyazawa, Haruna. “Increased serum PCSK9 concentrations are associated with periodontal infection but do not correlate with LDL cholesterol concentration : 血清PCSK9レベルの上昇は歯周炎罹患と関連するが、LDLコレステロールレベルとは相関しない.” 2014. Web. 23 Jan 2021.

Vancouver:

Miyazawa H. Increased serum PCSK9 concentrations are associated with periodontal infection but do not correlate with LDL cholesterol concentration : 血清PCSK9レベルの上昇は歯周炎罹患と関連するが、LDLコレステロールレベルとは相関しない. [Internet] [Thesis]. Niigata University / 新潟大学; 2014. [cited 2021 Jan 23]. Available from: http://hdl.handle.net/10191/27391.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Miyazawa H. Increased serum PCSK9 concentrations are associated with periodontal infection but do not correlate with LDL cholesterol concentration : 血清PCSK9レベルの上昇は歯周炎罹患と関連するが、LDLコレステロールレベルとは相関しない. [Thesis]. Niigata University / 新潟大学; 2014. Available from: http://hdl.handle.net/10191/27391

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of New South Wales

3. Kazim, Abdulla. The novel role of endosomal sorting proteins in intracellular cholesterol transport.

Degree: Biotechnology & Biomolecular Sciences, 2012, University of New South Wales

URL: http://handle.unsw.edu.au/1959.4/52092 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:10762/SOURCE01?view=true

► Cholesterol is an essential mammalian membrane component. In mammalian cells, cholesterol homeostasis needs to be tightly regulated since the aberrant intracellular cholesterol transport and storage… (more)

Subjects/Keywords: npc1; vps4; hrs; Cholesterol; ESCRT; LDL; endosome

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APA (6^th Edition):

Kazim, A. (2012). The novel role of endosomal sorting proteins in intracellular cholesterol transport. (Masters Thesis). University of New South Wales. Retrieved from http://handle.unsw.edu.au/1959.4/52092 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:10762/SOURCE01?view=true

Chicago Manual of Style (16^th Edition):

Kazim, Abdulla. “The novel role of endosomal sorting proteins in intracellular cholesterol transport.” 2012. Masters Thesis, University of New South Wales. Accessed January 23, 2021. http://handle.unsw.edu.au/1959.4/52092 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:10762/SOURCE01?view=true.

MLA Handbook (7^th Edition):

Kazim, Abdulla. “The novel role of endosomal sorting proteins in intracellular cholesterol transport.” 2012. Web. 23 Jan 2021.

Vancouver:

Kazim A. The novel role of endosomal sorting proteins in intracellular cholesterol transport. [Internet] [Masters thesis]. University of New South Wales; 2012. [cited 2021 Jan 23]. Available from: http://handle.unsw.edu.au/1959.4/52092 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:10762/SOURCE01?view=true.

Council of Science Editors:

Kazim A. The novel role of endosomal sorting proteins in intracellular cholesterol transport. [Masters Thesis]. University of New South Wales; 2012. Available from: http://handle.unsw.edu.au/1959.4/52092 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:10762/SOURCE01?view=true

Universidade Estadual de Campinas

4. Freitas, Wladimir Magalhães de, 1967-. O papel do HDL colesterol na estratificação de risco cardiovascular entre indivíduos octogenários no contexto da prevenção primária = The role f HDL cholesterol in assessing cardiovascular risk in individuals with more than eighty years old in the primary prevention setting: The role f HDL cholesterol in assessing cardiovascular risk in individuals with more than eighty years old in the primary prevention setting.

Degree: 2016, Universidade Estadual de Campinas

URL: http://repositorio.unicamp.br/jspui/handle/REPOSIP/312486

► Abstract: Background/Objectives: Plasma level of low-density lipoprotein cholesterol (LDL-C) has become a major marker and the central preventive target for cardiovascular disease in a large… (more)

▼ Abstract: Background/Objectives: Plasma level of low-density lipoprotein cholesterol (LDL-C) has become a major marker and the central preventive target for cardiovascular disease in a large spectrum of clinical settings. However, recent reports have raised questions about the consistency of this concept in individuals aged of 80 years or older. Hence, the aim of this study was to evaluate in a carefully selected population if the association between lipid parameters and coronary atherosclerotic burden remains significant. Design, Setting, Participants, Measurements: Individuals aged of 80 years or older (n=208) who spontaneously sought primary prevention care and have never manifested cardiovascular disease, malnutrition, neoplastic or consumptive disease were enrolled for a cross-sectional analysis. Medical evaluation, anthropometric measurements, blood tests and cardiac computed tomography were obtained. Results: 1- In analyses adjusted for age, gender, diabetes, systolic and diastolic blood pressure, smoking and statin therapy no association was found between coronary calcium score (CCS) and LDL-C (1.79 (0.75-4.29)). There was no association between TG and CCS. The association between HDL-C and CCS was significant and robust in unadjusted (0.32 (0.15-0.67)) as well as in the fully adjusted analysis (0.34 (0.15-0.75)). Results: 2-All the coronary segments (>3.000) were assessed to the presence of coronary atherosclerotic plaques. Coronary atherosclerotic plaques by CCTA were classified according to previous studies: positive remodeling (PR), not calcified plaques (NCP) and spotty calcification (SC). Individuals were categorized in the presence or absence of PR, NCP and SC and highest and lowest to the last quartile of the lipid profile (HDL-C (? 63 vs < 63mg/Dl), LDL-C ? 138 vs < 138 mg/dL, TG (?156 vs <156 mg/dL)). Results-In adjusted analysis by age, gender, body fat, hypertension, creatinine, CRP, diabetes mellitus, smoking, physical activity and use of statin all type of plaques with instability phenotype were associated with age. No association was found between LDL_C or TG and atherosclerotic plaques. Association remains between remodeling plaques and HDL-C< 63 mg/dL in fully adjusted model (2.5(1.1,-6.3);0.040) Conclusion: The present study confirms in a healthy cohort of individuals aged of 80 years or more that while the association between LDL cholesterol and coronary atherosclerosis weakens with aging, the opposite occurs with the levels of HDL cholesterol Advisors/Committee Members: UNIVERSIDADE ESTADUAL DE CAMPINAS (CRUESP), Sposito, Andrei Carvalho, 1967- (advisor), Universidade Estadual de Campinas. Faculdade de Ciências Médicas (institution), Programa de Pós-Graduação em Ciências Médicas (nameofprogram), Giraldez, Viviane Zorzanelli Rocha (committee member), Cazita, Patricia Miralda (committee member), Tambascia, Marcos Antonio (committee member), Silva, Thiago Quinaglia Araujo Costa e (committee member).

Subjects/Keywords: Aterosclerose; HDL-colesterol; LDL-colesterol; Idosos; Atherosclerosis; Cholesterol, HDL; Cholesterol, LDL; Aged

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APA (6^th Edition):

Freitas, Wladimir Magalhães de, 1. (2016). O papel do HDL colesterol na estratificação de risco cardiovascular entre indivíduos octogenários no contexto da prevenção primária = The role f HDL cholesterol in assessing cardiovascular risk in individuals with more than eighty years old in the primary prevention setting: The role f HDL cholesterol in assessing cardiovascular risk in individuals with more than eighty years old in the primary prevention setting. (Thesis). Universidade Estadual de Campinas. Retrieved from http://repositorio.unicamp.br/jspui/handle/REPOSIP/312486

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Freitas, Wladimir Magalhães de, 1967-. “O papel do HDL colesterol na estratificação de risco cardiovascular entre indivíduos octogenários no contexto da prevenção primária = The role f HDL cholesterol in assessing cardiovascular risk in individuals with more than eighty years old in the primary prevention setting: The role f HDL cholesterol in assessing cardiovascular risk in individuals with more than eighty years old in the primary prevention setting.” 2016. Thesis, Universidade Estadual de Campinas. Accessed January 23, 2021. http://repositorio.unicamp.br/jspui/handle/REPOSIP/312486.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Freitas, Wladimir Magalhães de, 1967-. “O papel do HDL colesterol na estratificação de risco cardiovascular entre indivíduos octogenários no contexto da prevenção primária = The role f HDL cholesterol in assessing cardiovascular risk in individuals with more than eighty years old in the primary prevention setting: The role f HDL cholesterol in assessing cardiovascular risk in individuals with more than eighty years old in the primary prevention setting.” 2016. Web. 23 Jan 2021.

Vancouver:

Freitas, Wladimir Magalhães de 1. O papel do HDL colesterol na estratificação de risco cardiovascular entre indivíduos octogenários no contexto da prevenção primária = The role f HDL cholesterol in assessing cardiovascular risk in individuals with more than eighty years old in the primary prevention setting: The role f HDL cholesterol in assessing cardiovascular risk in individuals with more than eighty years old in the primary prevention setting. [Internet] [Thesis]. Universidade Estadual de Campinas; 2016. [cited 2021 Jan 23]. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/312486.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Freitas, Wladimir Magalhães de 1. O papel do HDL colesterol na estratificação de risco cardiovascular entre indivíduos octogenários no contexto da prevenção primária = The role f HDL cholesterol in assessing cardiovascular risk in individuals with more than eighty years old in the primary prevention setting: The role f HDL cholesterol in assessing cardiovascular risk in individuals with more than eighty years old in the primary prevention setting. [Thesis]. Universidade Estadual de Campinas; 2016. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/312486

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universidade do Rio Grande do Sul

5. Spessatto, Débora. Associação dos níveis de HbA1c com colesterol LDL e colesterol LDL oxidado em indivíduos não-diabéticos.

Degree: 2011, Universidade do Rio Grande do Sul

URL: http://hdl.handle.net/10183/39649

► Introdução: O Diabetes mellitus (DM) está associado a complicações crônicas micro e macrovasculares. A medida da hemoglobina glicada (HbA1c) avalia o grau do controle glicêmico… (more)

▼ Introdução: O Diabetes mellitus (DM) está associado a complicações crônicas micro e macrovasculares. A medida da hemoglobina glicada (HbA1c) avalia o grau do controle glicêmico em pacientes diabéticos e seus níveis são capazes de prognosticar o risco de desenvolvimento dessas complicações. Entre as origens das complicações causadas pela hiperglicemia, há a hipótese dos produtos finais de glicação avançada (AGEs) e do estresse oxidativo. A reação de glicação não enzimática das proteínas também está relacionada com as complicações diabéticas e é responsável pela formação da HbA1c. Entretanto, tem sido demonstrado um aumento dessa glicação em pacientes não diabéticos. Um dos prováveis mecanismos para esse aumento é a peroxidação lipídica, com conseqüente aumento nos níveis de malondialdeído (MDA) que modifica a apolipoproteína B (APO B) do colesterol de baixa densidade (LDL). A modificação oxidativa do LDL confere propriedades específicas pró-aterogênicas. A presença do LDL oxidado e o aumento da tendência do LDL à peroxidação lipídica, podem contribuir para o aumento dos níveis de HbA1c. Objetivo: Verificar a associação entre os níveis de HbA1c com o Colesterol LDL e LDL oxidado em Indivíduos não-diabéticos. Métodos: Foi realizado um estudo transversal observacional, no qual um total de 196 indivíduos, classificados como não-diabéticos, foram analisados e divididos em três grupos, conforme os valores de HbA1c e glicemia de jejum (GJ): Grupo 1 (n =64) - HbA1c <5,7% e GJ <100 mg/dL; Grupo 2 (n =69) - HbA1c ≥5,7 e ≤6,4% e GJ <100 mg/dL; Grupo 3 (n =63) - HbA1c ≥5,7 e ≤6,4% e GJ ≥100 e <126mg/dL. Amostras de sangue total e soro foram coletadas. O LDL oxidado foi medido por método imunoensaio enzimático (Mercodia ®), ApoB dosada por imunoturbidimentria, a relação Colesterol LDL(oxi)/Colesterol-HDL foi estimada, além das outras dosagens bioquímicas do perfil lipídico. Esses testes foram comparados e analisados entre os três diferentes grupos. Resultados: Houve diferença significativa nos níveis de LDL(oxi) (p< 0,001), Apo B (p= 0,026) e razão LDL(oxi)/HDL (p< 0,001) entre os três grupos. Os valores de HbA1c apresentaram correlação positiva com os valores de LDL (oxi) (r =0,431; p <0,001), LDL (r =0,148; p =0,039), Col Não-HDL (r =0,192; p =0,007) e Apo B (r =0,171; p <0,001). Estas associações positivas permaneceram significativas, mesmo após ajuste, por análise de regressão linear múltipla para as variáveis álcool, medicamentos, índice de massa corporal (IMC) e idade. Também apresentaram correlações positivas com os valores de HbA1c: razão LDL (oxi)/HDL (r =0,422; p <0,001), CT (r =0,142; p =0,048), triglicerídios (r =0,155; p =0,030) e IMC (r =0,263; p <0,001). Conclusão: Nosso estudo demonstrou associação dos níveis de HbA1c com as partículas lipídicas aterogênicas LDL, Apo B, colesterol não HDL e LDL (oxi). Os níveis de LDL, principalmente LDL (oxi), estão significativamente associados com os níveis de HbA1c e glicose, mesmo em indivíduos não-diabéticos. Os indivíduos classificados com alto risco de desenvolver DM ou… Advisors/Committee Members: Camargo, Joiza Lins.

Subjects/Keywords: HDL-colesterol; Diabetes mellitus; LDL-colesterol; Glycated hemoglobin; Oxidized cholesterol LDL; Hemoglobina A glicosilada

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Spessatto, D. (2011). Associação dos níveis de HbA1c com colesterol LDL e colesterol LDL oxidado em indivíduos não-diabéticos. (Thesis). Universidade do Rio Grande do Sul. Retrieved from http://hdl.handle.net/10183/39649

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Spessatto, Débora. “Associação dos níveis de HbA1c com colesterol LDL e colesterol LDL oxidado em indivíduos não-diabéticos.” 2011. Thesis, Universidade do Rio Grande do Sul. Accessed January 23, 2021. http://hdl.handle.net/10183/39649.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Spessatto, Débora. “Associação dos níveis de HbA1c com colesterol LDL e colesterol LDL oxidado em indivíduos não-diabéticos.” 2011. Web. 23 Jan 2021.

Vancouver:

Spessatto D. Associação dos níveis de HbA1c com colesterol LDL e colesterol LDL oxidado em indivíduos não-diabéticos. [Internet] [Thesis]. Universidade do Rio Grande do Sul; 2011. [cited 2021 Jan 23]. Available from: http://hdl.handle.net/10183/39649.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Spessatto D. Associação dos níveis de HbA1c com colesterol LDL e colesterol LDL oxidado em indivíduos não-diabéticos. [Thesis]. Universidade do Rio Grande do Sul; 2011. Available from: http://hdl.handle.net/10183/39649

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

6. Arnal, Maud. Bis(Monoacylglycéro)Phosphate, oxystérols et ORP11 : un trio régulateur du trafic du cholestérol dans les macrophages : Bis(Monoacylglycero)Phosphate, oxysterols and ORP11 : a threesome regulating intracellular cholesterol traffic in macrophages.

Degree: Docteur es, Biochimie, 2015, Université Claude Bernard – Lyon I

URL: http://www.theses.fr/2015LYO10288

►

L'athérosclérose est une complication cardiovasculaire majeure des maladies liées à une augmentation du stress oxydatif, comme le diabète de type 2 et le syndrome métabolique.… (more)

▼

L'athérosclérose est une complication cardiovasculaire majeure des maladies liées à une augmentation du stress oxydatif, comme le diabète de type 2 et le syndrome métabolique. Dans ces situations, les lipoprotéines de faible densité (LDL) subissent une oxydation et leur forte absorption induit une accumulation de cholestérol dans les macrophages sous-endothéliaux. D'autre part, les LDL oxydées sont enrichies en produits d'oxydation du cholestérol appelés oxystérols, dont certains sont impliqués dans la capacité des LDL oxydées à induire un stress oxydant cellulaire et une cytotoxicité, principalement par apoptose. Le Bis(Monoacylglycéro)Phosphate (BMP) est un phospholipide unique, localisé préférentiellement dans les endosomes tardifs, compartiment cellulaire clef dans le métabolisme du cholestérol dérivé des LDL. Lors de travaux antérieurs, l'équipe a démontré le rôle prépondérant du BMP dans la régulation de l'homéostasie du cholestérol dans les macrophages. L'objectif de ce travail a été de décrypter les mécanismes moléculaires intervenant dans le trafic intracellulaire du cholestérol. Ainsi, le BMP régule l'efflux de cholestérol par les HDL (high density lipoproteins) grâce à des mécanismes impliquant les LXRs (liver X receptors) et les transporteurs ABCA1/ABCG1 (ATP binding cassette-type A1/G1). De plus, notre étude indique que le BMP exerce également un rôle protecteur contre l'effet pro-apoptotique des LDL oxydées via la réduction de la production intracellulaire d'oxystérols. Comme une partie du trafic intracellulaire des stérols au sein des macrophages est régulé par OSBP (oxysterol binding protein) et ses protéines dérivées, les ORPs (OSBP-related proteins), nous montrons dans ce rapport que l'action de protection du BMP contre les effets cytotoxiques des oxystérols est fortement diminuée dans des cellules où la protéine ORP11 est supprimée, suggérant que le BMP exerce son rôle protecteur via un mécanisme utilisant la fonction d'ORP11 dans le transport intracellulaire de stérols

Atherosclerosis is a major cardiovascular complication in increased oxidative stress-related diseases such as type 2 diabetes and metabolic syndrome. In these situations, the low density lipoproteins (LDL) undergo oxidation and their high uptake induces cholesterol accumulation in subendothelial macrophages. On the other hand, oxidized LDL are enriched in cholesterol oxidation products called oxysterols, some of them are involved in the ability of oxidized LDL to induce cellular oxidative stress and cytotoxicity, mainly by apoptosis. Bis(Monoacylglycero)Phosphate (BMP) is a unique phospholipid localized preferentially in late endosomes, a central cellular compartment of LDL-cholesterol metabolism. In previous work, the team demonstrated the leading role of BMP in regulation of cholesterol homeostasis in macrophages. The aim of this work was to characterize the molecular mechanisms involved in the intracellular trafficking of cholesterol. Thus, BMP regulates cholesterol efflux to HDL (high density lipoproteins) by mechanisms…

Advisors/Committee Members: Costaz, Céline (thesis director), Vandenbroucke, Isabelle (thesis director).

Subjects/Keywords: BMP; Oxystérols; OSBP; ORP; Cholestérol; LDL; Macrophages; BMP; Oxysterols; OSBP; ORP; Cholesterol; LDL; Macrophages; 572

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Arnal, M. (2015). Bis(Monoacylglycéro)Phosphate, oxystérols et ORP11 : un trio régulateur du trafic du cholestérol dans les macrophages : Bis(Monoacylglycero)Phosphate, oxysterols and ORP11 : a threesome regulating intracellular cholesterol traffic in macrophages. (Doctoral Dissertation). Université Claude Bernard – Lyon I. Retrieved from http://www.theses.fr/2015LYO10288

Chicago Manual of Style (16^th Edition):

Arnal, Maud. “Bis(Monoacylglycéro)Phosphate, oxystérols et ORP11 : un trio régulateur du trafic du cholestérol dans les macrophages : Bis(Monoacylglycero)Phosphate, oxysterols and ORP11 : a threesome regulating intracellular cholesterol traffic in macrophages.” 2015. Doctoral Dissertation, Université Claude Bernard – Lyon I. Accessed January 23, 2021. http://www.theses.fr/2015LYO10288.

MLA Handbook (7^th Edition):

Arnal, Maud. “Bis(Monoacylglycéro)Phosphate, oxystérols et ORP11 : un trio régulateur du trafic du cholestérol dans les macrophages : Bis(Monoacylglycero)Phosphate, oxysterols and ORP11 : a threesome regulating intracellular cholesterol traffic in macrophages.” 2015. Web. 23 Jan 2021.

Vancouver:

Arnal M. Bis(Monoacylglycéro)Phosphate, oxystérols et ORP11 : un trio régulateur du trafic du cholestérol dans les macrophages : Bis(Monoacylglycero)Phosphate, oxysterols and ORP11 : a threesome regulating intracellular cholesterol traffic in macrophages. [Internet] [Doctoral dissertation]. Université Claude Bernard – Lyon I; 2015. [cited 2021 Jan 23]. Available from: http://www.theses.fr/2015LYO10288.

Council of Science Editors:

Arnal M. Bis(Monoacylglycéro)Phosphate, oxystérols et ORP11 : un trio régulateur du trafic du cholestérol dans les macrophages : Bis(Monoacylglycero)Phosphate, oxysterols and ORP11 : a threesome regulating intracellular cholesterol traffic in macrophages. [Doctoral Dissertation]. Université Claude Bernard – Lyon I; 2015. Available from: http://www.theses.fr/2015LYO10288

Uniwersytet im. Adama Mickiewicza w Poznaniu

7. Banaszewska, Anna. Udział Białka PCSK9 w patogenezie miażdżycy u osób z ostrym zespołem wieńcowym .

Degree: 2012, Uniwersytet im. Adama Mickiewicza w Poznaniu

URL: http://hdl.handle.net/10593/4022

► Odkąd odkryto, że PCSK9 (ang. Proprotein Convertase Subtilisin/Kexin type 9) degraduje receptory LDL, stało się ono jednym z głównych obiektów badań nad miażdżycą. Celem niniejszej… (more)

Subjects/Keywords: PCSK9; receptor LDL; LDL receptor; cholesterol; ostry zespół wieńcowy; acute coronary syndrome; miażdżyca; atherosclerosis

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Banaszewska, A. (2012). Udział Białka PCSK9 w patogenezie miażdżycy u osób z ostrym zespołem wieńcowym . (Doctoral Dissertation). Uniwersytet im. Adama Mickiewicza w Poznaniu. Retrieved from http://hdl.handle.net/10593/4022

Chicago Manual of Style (16^th Edition):

Banaszewska, Anna. “Udział Białka PCSK9 w patogenezie miażdżycy u osób z ostrym zespołem wieńcowym .” 2012. Doctoral Dissertation, Uniwersytet im. Adama Mickiewicza w Poznaniu. Accessed January 23, 2021. http://hdl.handle.net/10593/4022.

MLA Handbook (7^th Edition):

Banaszewska, Anna. “Udział Białka PCSK9 w patogenezie miażdżycy u osób z ostrym zespołem wieńcowym .” 2012. Web. 23 Jan 2021.

Vancouver:

Banaszewska A. Udział Białka PCSK9 w patogenezie miażdżycy u osób z ostrym zespołem wieńcowym . [Internet] [Doctoral dissertation]. Uniwersytet im. Adama Mickiewicza w Poznaniu; 2012. [cited 2021 Jan 23]. Available from: http://hdl.handle.net/10593/4022.

Council of Science Editors:

Banaszewska A. Udział Białka PCSK9 w patogenezie miażdżycy u osób z ostrym zespołem wieńcowym . [Doctoral Dissertation]. Uniwersytet im. Adama Mickiewicza w Poznaniu; 2012. Available from: http://hdl.handle.net/10593/4022

University of Otago

8. Jones, Rhiannon Mihi. A meta-analysis on the effects of dietary sugars on blood lipids .

Degree: 2013, University of Otago

URL: http://hdl.handle.net/10523/3861

► Background: Increasing sugars intakes has been linked to an increased risk of cardiovascular disease such as diabetes, insulin resistance and obesity. When sugars are consumed… (more)

▼ Background: Increasing sugars intakes has been linked to an increased risk of cardiovascular disease such as diabetes, insulin resistance and obesity. When sugars are consumed in excess of energy requirements and glycogen storage capacity they are converted to lipids in the liver and stored as fat. This also results in an increase in circulating lipid concentrations in the blood. The aim of this thesis was to determine whether there is a relationship between consumption of dietary sugars and blood lipids as a biomarker of cardiovascular risk. Design: Systematic review and meta-analysis of randomised controlled trials (RCTs) following the Cochrane Collaboration guidelines including and using Cochrane meta-analysis software Revman 5.0. Data sources: Four article databases (OVID Medline, Scopus, Embase and CINAHL) were searched for randomised controlled trials published before April 2012. Grey literature sources and references lists of review articles were also searched. Study selection: We included randomised controlled trials from 1960 to the present, where dietary sugars intake was increased in one arm of the study in comparison with another and which reported effects on one of the following outcome measures; triglycerides, HDL, LDL or total cholesterol. Participants were healthy subjects who were not affected by a metabolism-altering disease and were not undergoing any acute treatment for disease. Data synthesis: Mean pooled effects of higher versus lower sugars intakes on lipid outcome measures were estimated using inverse variance models of analysis with random effects to account for heterogeneity. Subgroup analyses further examined the effects of study length, study type, provision of intervention, type of intervention, type of control group, weight loss and diabetes on the association between sugars intake and lipids. Results: 17,020 potentially relevant studies were identified by electronic searches. 35 studies remained after deduplication and exclusion of studies that did not meet the inclusion criteria. 873 participants participating in 10 parallel trials and 25 crossover trials were included. Higher compared with lower sugars intakes was associated with raised triglycerides (0.13mmol/L [95% confidence interval (CI) = 0.07, 0.20]), LDL cholesterol (0.20mmol/L [95% CI = 0.07, 0.33]) and total cholesterol (0.07mmol/L [95% CI = 0.03, 0.10]). There was no significant association with HDL cholesterol. Weight increase in those with a high dietary sugar intake was associated with a significant decrease in total cholesterol in contrast with no weight change, which was associated with an increase in total cholesterol. The effects of sugars in lipids were strengthened in crossover trials, those trials where dietary intake was isoenergetic and in interventions where sugars were exchanged for complex carbohydrates rather than other simple carbohydrates. Accounting for potential bias attenuated the findings somewhat. Conclusions: This meta-analysis provides evidence that high dietary sugars intake is… Advisors/Committee Members: Te Morenga, Lisa (advisor).

Subjects/Keywords: lipids; cholesterol; HDL; LDL; triglycerides; sugars; meta-analysis

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Jones, R. M. (2013). A meta-analysis on the effects of dietary sugars on blood lipids . (Masters Thesis). University of Otago. Retrieved from http://hdl.handle.net/10523/3861

Chicago Manual of Style (16^th Edition):

Jones, Rhiannon Mihi. “A meta-analysis on the effects of dietary sugars on blood lipids .” 2013. Masters Thesis, University of Otago. Accessed January 23, 2021. http://hdl.handle.net/10523/3861.

MLA Handbook (7^th Edition):

Jones, Rhiannon Mihi. “A meta-analysis on the effects of dietary sugars on blood lipids .” 2013. Web. 23 Jan 2021.

Vancouver:

Jones RM. A meta-analysis on the effects of dietary sugars on blood lipids . [Internet] [Masters thesis]. University of Otago; 2013. [cited 2021 Jan 23]. Available from: http://hdl.handle.net/10523/3861.

Council of Science Editors:

Jones RM. A meta-analysis on the effects of dietary sugars on blood lipids . [Masters Thesis]. University of Otago; 2013. Available from: http://hdl.handle.net/10523/3861

University of Otago

9. Ong, Jasmine Xiuping. “The Tailored Diet Study”: The effect of tailored dietary modification on lipid levels in FH participants .

Degree: 2013, University of Otago

URL: http://hdl.handle.net/10523/4192

► Rationale: Risk factors for cardiovascular disease (CVD) are both modifiable and non-modifiable. Modifiable risk factors associated with CVD poor diet quality, physical inactivity and tobacco… (more)

▼ Rationale: Risk factors for cardiovascular disease (CVD) are both modifiable and non-modifiable. Modifiable risk factors associated with CVD poor diet quality, physical inactivity and tobacco consumption. Individuals with familial hypercholesterolemia (FH) have inherited genetic disorders affecting low-density lipoprotein receptors. These individuals are predisposed to a greater risk of CVD due to increased low-density lipoprotein cholesterol (LDL-C) levels. Dietary modifications remain an important part of CVD risk reduction in FH. Methods: This study was a pre and post intervention design that ran over eight weeks. We recruited FH participants through GP practices in Dunedin and Southland. Dietary assessment for each participant was carried out using a prompted 24-hour recall and a semi-quantitative FFQ. The FFQ was used to create a simulated 7-day diet record for each participant. This was done at baseline and repeated at the end of the study. Nutrient analyses of diets were done using Kai-culator©. Blood lipids were compared pre and post intervention. The blood lipid measurements were taken for total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), LDL-C, triglycerides (TAG), and TC:HDL ratio. Spearman’s correlations and paired t-tests were carried out to determining changes in nutrient intakes and their associations with lipid changes. Results: No significant differences were found between pre and post mean levels of TC, HDL-C, LDL-C, TAG or TC:HDL-C. There were significant reductions in intakes of biscuits (p=0.002), eggs and egg dishes (p=0.027), bread based dishes (p=0.012) and processed meat (p=0.008). There were also significant increases in intakes of fish and seafood (p=0.003), nuts (p=0.002),fruit (p=0.012), and vegetables (p=0.016) and table spread (p=0.048). This related to a significant reduction in intakes of saturated fatty acids (p<0.001), cholesterol (p=0.003) and an increase in monounsaturated (p=0.01) and polyunsaturated fatty acids (p=0.035). Qualitative feedback indicated that the majority of participants found the study to be helpful in increasing their understanding of heart healthy eating habits, and in changing their dietary practices. Conclusions: This short term intervention showed that tailored dietary advice was effective in changing nutrient and food group intakes towards a more optimal diet. This study was limited due to the small sample size (n=25) and short study duration. Advisors/Committee Members: Mann, Jim (advisor).

Subjects/Keywords: Diet; Lipid; cardiovascular disease; LDL cholesterol; Familial hypercholesterolemia

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Ong, J. X. (2013). “The Tailored Diet Study”: The effect of tailored dietary modification on lipid levels in FH participants . (Masters Thesis). University of Otago. Retrieved from http://hdl.handle.net/10523/4192

Chicago Manual of Style (16^th Edition):

Ong, Jasmine Xiuping. ““The Tailored Diet Study”: The effect of tailored dietary modification on lipid levels in FH participants .” 2013. Masters Thesis, University of Otago. Accessed January 23, 2021. http://hdl.handle.net/10523/4192.

MLA Handbook (7^th Edition):

Ong, Jasmine Xiuping. ““The Tailored Diet Study”: The effect of tailored dietary modification on lipid levels in FH participants .” 2013. Web. 23 Jan 2021.

Vancouver:

Ong JX. “The Tailored Diet Study”: The effect of tailored dietary modification on lipid levels in FH participants . [Internet] [Masters thesis]. University of Otago; 2013. [cited 2021 Jan 23]. Available from: http://hdl.handle.net/10523/4192.

Council of Science Editors:

Ong JX. “The Tailored Diet Study”: The effect of tailored dietary modification on lipid levels in FH participants . [Masters Thesis]. University of Otago; 2013. Available from: http://hdl.handle.net/10523/4192

University of Iowa

10. Persons, Jane Elizabeth. Characterizing the relationship between low serum low-density lipoprotein and depressive symptoms.

Degree: PhD, Epidemiology, 2016, University of Iowa

URL: https://ir.uiowa.edu/etd/5600

► The purpose of this study was to resolve a critical gap in depression literature through assessment of the temporal relationship between depression and low… (more)

Subjects/Keywords: Biomarkers; Cholesterol; Depression; LDL; Lipids; WHI; Clinical Epidemiology

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APA (6^th Edition):

Persons, J. E. (2016). Characterizing the relationship between low serum low-density lipoprotein and depressive symptoms. (Doctoral Dissertation). University of Iowa. Retrieved from https://ir.uiowa.edu/etd/5600

Chicago Manual of Style (16^th Edition):

Persons, Jane Elizabeth. “Characterizing the relationship between low serum low-density lipoprotein and depressive symptoms.” 2016. Doctoral Dissertation, University of Iowa. Accessed January 23, 2021. https://ir.uiowa.edu/etd/5600.

MLA Handbook (7^th Edition):

Persons, Jane Elizabeth. “Characterizing the relationship between low serum low-density lipoprotein and depressive symptoms.” 2016. Web. 23 Jan 2021.

Vancouver:

Persons JE. Characterizing the relationship between low serum low-density lipoprotein and depressive symptoms. [Internet] [Doctoral dissertation]. University of Iowa; 2016. [cited 2021 Jan 23]. Available from: https://ir.uiowa.edu/etd/5600.

Council of Science Editors:

Persons JE. Characterizing the relationship between low serum low-density lipoprotein and depressive symptoms. [Doctoral Dissertation]. University of Iowa; 2016. Available from: https://ir.uiowa.edu/etd/5600

University of Ottawa

11. Matyas, Angela. The Functional Characterization of PCSK9's Binding Interactions with LDL and the LDL Receptor .

Degree: 2020, University of Ottawa

URL: http://hdl.handle.net/10393/40592

► Elevated plasma cholesterol is a risk factor for cardiovascular disease. Proprotein convertase subtilisin/kexin type 9 (PCSK9) hinders the uptake of low-density lipoprotein cholesterol (LDL-c) by… (more)

Subjects/Keywords: PCSK9; LDLR; Hypercholesterolemia; Natural mutations; LDL-cholesterol; Cardiovascular disease

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APA (6^th Edition):

Matyas, A. (2020). The Functional Characterization of PCSK9's Binding Interactions with LDL and the LDL Receptor . (Thesis). University of Ottawa. Retrieved from http://hdl.handle.net/10393/40592

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Matyas, Angela. “The Functional Characterization of PCSK9's Binding Interactions with LDL and the LDL Receptor .” 2020. Thesis, University of Ottawa. Accessed January 23, 2021. http://hdl.handle.net/10393/40592.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Matyas, Angela. “The Functional Characterization of PCSK9's Binding Interactions with LDL and the LDL Receptor .” 2020. Web. 23 Jan 2021.

Vancouver:

Matyas A. The Functional Characterization of PCSK9's Binding Interactions with LDL and the LDL Receptor . [Internet] [Thesis]. University of Ottawa; 2020. [cited 2021 Jan 23]. Available from: http://hdl.handle.net/10393/40592.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Matyas A. The Functional Characterization of PCSK9's Binding Interactions with LDL and the LDL Receptor . [Thesis]. University of Ottawa; 2020. Available from: http://hdl.handle.net/10393/40592

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Georgia State University

12. Alam, Aniqa. Apolipoprotein B is More Strongly Associated with Cardiovascular Risk Factors than Low-Density Lipoprotein Cholesterol in Young-to-Middle Aged Adults.

Degree: MPH, Public Health, 2018, Georgia State University

URL: https://scholarworks.gsu.edu/iph_theses/559

► Cardiovascular disease (CVD) is the leading cause of death in the United States. Medical practitioners and public health officials alike consider atherosclerosis, in which… (more)

Subjects/Keywords: cardiovascular disease; ldl cholesterol; apolipoprotein b; age; nhanes

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APA (6^th Edition):

Alam, A. (2018). Apolipoprotein B is More Strongly Associated with Cardiovascular Risk Factors than Low-Density Lipoprotein Cholesterol in Young-to-Middle Aged Adults. (Thesis). Georgia State University. Retrieved from https://scholarworks.gsu.edu/iph_theses/559

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Alam, Aniqa. “Apolipoprotein B is More Strongly Associated with Cardiovascular Risk Factors than Low-Density Lipoprotein Cholesterol in Young-to-Middle Aged Adults.” 2018. Thesis, Georgia State University. Accessed January 23, 2021. https://scholarworks.gsu.edu/iph_theses/559.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Alam, Aniqa. “Apolipoprotein B is More Strongly Associated with Cardiovascular Risk Factors than Low-Density Lipoprotein Cholesterol in Young-to-Middle Aged Adults.” 2018. Web. 23 Jan 2021.

Vancouver:

Alam A. Apolipoprotein B is More Strongly Associated with Cardiovascular Risk Factors than Low-Density Lipoprotein Cholesterol in Young-to-Middle Aged Adults. [Internet] [Thesis]. Georgia State University; 2018. [cited 2021 Jan 23]. Available from: https://scholarworks.gsu.edu/iph_theses/559.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Alam A. Apolipoprotein B is More Strongly Associated with Cardiovascular Risk Factors than Low-Density Lipoprotein Cholesterol in Young-to-Middle Aged Adults. [Thesis]. Georgia State University; 2018. Available from: https://scholarworks.gsu.edu/iph_theses/559

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of New South Wales

13. Petrides, Francine. The role of PCSK9 in Familial Hypercholesterolemic subjects and in subjects at high cardiovascular risk treated with statins and a CETP inhibitor.

Degree: Medicine :, 2015, University of New South Wales

URL: http://handle.unsw.edu.au/1959.4/55609 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:38163/SOURCE02?view=true

► Cardiovascular disease (CVD) is one of the leading causes of death in the developingworld, killing one Australian every twelve minutes (www.heartfoundation.com.au).Hypercholesterolemia and long term elevated… (more)

▼ Cardiovascular disease (CVD) is one of the leading causes of death in the developingworld, killing one Australian every twelve minutes (www.heartfoundation.com.au).Hypercholesterolemia and long term elevated LDL-cholesterol (LDL-C) levels arelinked to the formation of atherosclerotic plaques, which can eventually lead tomyocardial infarction or stroke. It is therefore essential to lower LDL-C levels in orderto reduce cardiovascular (CV) risk.The low density lipoprotein receptor (LDLR) removes and degrades LDL particlesfrom circulation. Proprotein convertase subtilisin kexin type 9 (PCSK9) regulatescholesterol metabolism by degrading the LDLR. A number of pharmaceuticalcompanies have created therapeutic agents known as PCSK9 inhibitors, which bind toand block PCSK9. PCSK9 inhibitors in combination with existing lipid loweringtreatments have been shown to significantly decrease circulating LDL-C levels in awide variety of subjects. The aim of thesis was to examine the biology of PCSK9 insubjects with familial hypercholesterolemia (FH), in subjects at high CV risk and insubjects treated with a CETP inhibitor.The ex vivo and in vitro studies in this thesis demonstrated that statins increased,recombinant PCSK9 decreased, and the PCSK9 inhibitor restored LDLR cell surfaceexpression in all heFH and receptor defective hoFH subjects. However, LDLR cellsurface expression was not affected in receptor negative hoFH subjects. In subjects athigh CV risk the administration of ascending atorvastatin doses increased plasmaPCSK9 levels at each individual dose. Subjects with diabetes who were treated withatorvastatin also had significantly higher plasma PCSK9 levels compared to subjectswithout diabetes. However, the administration of the CETP inhibitor, torcetrapib hadno effect on circulating PCSK9 levels in subjects with or without diabetes.These results from this thesis provided a novel insight into PCSK9 biology and haveimportant clinical implications for subjects diagnosed with FH and in subjects at highCV risk. The results from these studies support current clinical trial results and providestrong in vitro and ex vivo evidence for the use of PCSK9 inhibitors in all heFH,receptor defective hoFH and statin treated subjects at high CV risk with or withouttype 2 diabetes.

Subjects/Keywords: PCSK9; Familial Hypercholesterolemic; CETP inhibitor; Cardiovascular disease (CVD); Hypercholesterolemia; LDL-cholesterol

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Petrides, F. (2015). The role of PCSK9 in Familial Hypercholesterolemic subjects and in subjects at high cardiovascular risk treated with statins and a CETP inhibitor. (Doctoral Dissertation). University of New South Wales. Retrieved from http://handle.unsw.edu.au/1959.4/55609 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:38163/SOURCE02?view=true

Chicago Manual of Style (16^th Edition):

Petrides, Francine. “The role of PCSK9 in Familial Hypercholesterolemic subjects and in subjects at high cardiovascular risk treated with statins and a CETP inhibitor.” 2015. Doctoral Dissertation, University of New South Wales. Accessed January 23, 2021. http://handle.unsw.edu.au/1959.4/55609 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:38163/SOURCE02?view=true.

MLA Handbook (7^th Edition):

Petrides, Francine. “The role of PCSK9 in Familial Hypercholesterolemic subjects and in subjects at high cardiovascular risk treated with statins and a CETP inhibitor.” 2015. Web. 23 Jan 2021.

Vancouver:

Petrides F. The role of PCSK9 in Familial Hypercholesterolemic subjects and in subjects at high cardiovascular risk treated with statins and a CETP inhibitor. [Internet] [Doctoral dissertation]. University of New South Wales; 2015. [cited 2021 Jan 23]. Available from: http://handle.unsw.edu.au/1959.4/55609 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:38163/SOURCE02?view=true.

Council of Science Editors:

Petrides F. The role of PCSK9 in Familial Hypercholesterolemic subjects and in subjects at high cardiovascular risk treated with statins and a CETP inhibitor. [Doctoral Dissertation]. University of New South Wales; 2015. Available from: http://handle.unsw.edu.au/1959.4/55609 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:38163/SOURCE02?view=true

Leiden University

14. Thiele, P. The relationship between suicide and serum cholesterol in people with life-time depression diagnosis and healthy control participants.

Degree: 2015, Leiden University

URL: http://hdl.handle.net/1887/36488

Subjects/Keywords: Serum cholesterol; depression; suicide; HDL cholesterol; LDL cholesterol

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Thiele, P. (2015). The relationship between suicide and serum cholesterol in people with life-time depression diagnosis and healthy control participants. (Masters Thesis). Leiden University. Retrieved from http://hdl.handle.net/1887/36488

Chicago Manual of Style (16^th Edition):

Thiele, P. “The relationship between suicide and serum cholesterol in people with life-time depression diagnosis and healthy control participants.” 2015. Masters Thesis, Leiden University. Accessed January 23, 2021. http://hdl.handle.net/1887/36488.

MLA Handbook (7^th Edition):

Thiele, P. “The relationship between suicide and serum cholesterol in people with life-time depression diagnosis and healthy control participants.” 2015. Web. 23 Jan 2021.

Vancouver:

Thiele P. The relationship between suicide and serum cholesterol in people with life-time depression diagnosis and healthy control participants. [Internet] [Masters thesis]. Leiden University; 2015. [cited 2021 Jan 23]. Available from: http://hdl.handle.net/1887/36488.

Council of Science Editors:

Thiele P. The relationship between suicide and serum cholesterol in people with life-time depression diagnosis and healthy control participants. [Masters Thesis]. Leiden University; 2015. Available from: http://hdl.handle.net/1887/36488

15. Gomes, Ana Lúcia Flora Santos. A Saliva como potencial meio de diagnóstico.

Degree: 2015, RCAAP

URL: https://www.rcaap.pt/detail.jsp?id=oai:repositorio.cespu.pt:20.500.11816/2625

► Os múltiplos constituintes salivares podem ser utilizados como biomarcadores de doenças e condições sistémicas do indivíduo. A natureza não invasiva da colheita da saliva é… (more)

▼ Os múltiplos constituintes salivares podem ser utilizados como biomarcadores de doenças e condições sistémicas do indivíduo. A natureza não invasiva da colheita da saliva é atrativa como método alternativo ao usado para o sangue. Alguns analitos são difíceis de detetar devido à sua baixa concentração na saliva. Este estudo tem como objetivo avaliar a correlação entre os níveis de PCR de alta sensibilidade (asPCR), Colesterol total, Colesterol LDL, Colesterol HDL, Triglicerídeos, Ácido Úrico e Ureia em amostras de saliva e sangue, assegurando a reprodutibilidade dos métodos. Participaram neste estudo 42 indivíduos saudáveis (21 do sexo masculino e 21 do sexo feminino). As metodologias utilizadas foram: o método enzimático colorimétrico (colesterol total, colesterol LDL, colesterol HDL, triglicerídeos e ácido úrico), método UV cinético (ureia) e nefelometria (asPCR). Os valores de concentração do colesterol total, colesterol LDL, colesterol HDL, triglicerídeos e asPCR foram inferiores ao limite de deteção do método. Na determinação quantitativa do ácido úrico e ureia observaram-se diferenças estatisticamente significativas (p<0,05), entre o soro e a saliva. A concentração de ácido úrico obtida na saliva resultou numa mediana 2,0 (Percentil 25-75; 1,2-2,4) mg/dL, sendo inferior à verificada no soro, 4,7 (4,0-5,2) mg/dL. Contrariamente, a concentração da ureia na saliva, com mediana de 35 (27-48) mg/dL, foi superior à verificada no soro 28 (26-32) mg/dL. Obteve-se uma correlação positiva fraca no ácido úrico (rs=0,16) e ureia (r2=0,40) , entre a saliva e o soro. O uso da saliva como meio de diagnóstico, é promissora para aplicação clínica, podendo este estudo contribuir para este propósito, juntamente com outros com maior numero de amostras, com valores de referência e curvas de calibração adaptados e que simultaneamente garantam a reprodutibilidade dos métodos. Advisors/Committee Members: Farinha, Rui Miguel Ribeiro Barbosa.

Subjects/Keywords: Saliva; Venous blood; Total cholesterol; LDL cholesterol; HDL cholesterol; Triglycerides; High senditive C-reactive protein (hs-CRP); Uric acid and urea

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APA (6^th Edition):

Gomes, A. L. F. S. (2015). A Saliva como potencial meio de diagnóstico. (Thesis). RCAAP. Retrieved from https://www.rcaap.pt/detail.jsp?id=oai:repositorio.cespu.pt:20.500.11816/2625

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Gomes, Ana Lúcia Flora Santos. “A Saliva como potencial meio de diagnóstico.” 2015. Thesis, RCAAP. Accessed January 23, 2021. https://www.rcaap.pt/detail.jsp?id=oai:repositorio.cespu.pt:20.500.11816/2625.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Gomes, Ana Lúcia Flora Santos. “A Saliva como potencial meio de diagnóstico.” 2015. Web. 23 Jan 2021.

Vancouver:

Gomes ALFS. A Saliva como potencial meio de diagnóstico. [Internet] [Thesis]. RCAAP; 2015. [cited 2021 Jan 23]. Available from: https://www.rcaap.pt/detail.jsp?id=oai:repositorio.cespu.pt:20.500.11816/2625.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Gomes ALFS. A Saliva como potencial meio de diagnóstico. [Thesis]. RCAAP; 2015. Available from: https://www.rcaap.pt/detail.jsp?id=oai:repositorio.cespu.pt:20.500.11816/2625

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Baylor University

16. Heimbach, Esther J. The effects of lowering uric acid levels using allopurinol on components of Metabolic Syndrome.

Degree: M.P.H., Health, Human Performance and Recreation., 2011, Baylor University

URL: http://hdl.handle.net/2104/8145

► Purpose: To determine the relationship between uric acid and lipid levels for the purpose of understanding more about the public health issue of Metabolic Syndrome.… (more)

Subjects/Keywords: Uric acid.; Metabolic Syndrome.; Allopurinol.; Triglycerides.; HDL-cholesterol.; LDL-cholesterol.; Total cholesterol.; Hyperuricemia.; Public health.; Lipid levels.

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Heimbach, E. J. (2011). The effects of lowering uric acid levels using allopurinol on components of Metabolic Syndrome. (Masters Thesis). Baylor University. Retrieved from http://hdl.handle.net/2104/8145

Chicago Manual of Style (16^th Edition):

Heimbach, Esther J. “The effects of lowering uric acid levels using allopurinol on components of Metabolic Syndrome.” 2011. Masters Thesis, Baylor University. Accessed January 23, 2021. http://hdl.handle.net/2104/8145.

MLA Handbook (7^th Edition):

Heimbach, Esther J. “The effects of lowering uric acid levels using allopurinol on components of Metabolic Syndrome.” 2011. Web. 23 Jan 2021.

Vancouver:

Heimbach EJ. The effects of lowering uric acid levels using allopurinol on components of Metabolic Syndrome. [Internet] [Masters thesis]. Baylor University; 2011. [cited 2021 Jan 23]. Available from: http://hdl.handle.net/2104/8145.

Council of Science Editors:

Heimbach EJ. The effects of lowering uric acid levels using allopurinol on components of Metabolic Syndrome. [Masters Thesis]. Baylor University; 2011. Available from: http://hdl.handle.net/2104/8145

17. Slhessarenko, Natasha. Determinação dos intervalos de referência do colesterol total, HDL-colesterol, colesterol não HDL, LDL-colesterol e triglicérides em crianças e adolescentes saudáveis do Município de Cuiabá, Mato Grosso, Brasil.

Degree: PhD, Pediatria, 2014, University of São Paulo

URL: http://www.teses.usp.br/teses/disponiveis/5/5141/tde-09062014-105138/ ;

► A determinação de Intervalos de Referência (IR) é uma árdua tarefa para os laboratórios clínicos, porém indispensável e de fundamental importância para a tomada de… (more)

▼ A determinação de Intervalos de Referência (IR) é uma árdua tarefa para os laboratórios clínicos, porém indispensável e de fundamental importância para a tomada de decisão médica. Para parâmetros como os lípides séricos, os IR tem sido estabelecidos consensos nacionais ou internacionais definindo limites de decisão (CLSI, 2008). O objetivo deste estudo foi determinar os IR para colesterol total, HDL-colesterol, colesterol não-HDL, LDL- colesterol e triglicérides séricos em crianças e adolescentes saudáveis do município de Cuiabá, capital do estado de Mato Grosso. Trata-se de um estudo transversal, descritivo, realizado em 1.866 crianças e adolescentes saudáveis de creches e escolas municipais desta capital, obtidas por amostragem aleatória. Foi aplicado um questionário avaliando antecedentes do indivíduo e de seus familiares além de dados demográficos e antropométricos. Foram definidos como critérios de inclusão do estudo, crianças e adolescentes nas faixas etárias de 1 a 12 anos 11 meses e 29 dias, sem nenhuma doença de base diagnosticada ou queixas clínicas no momento da coleta. Além disto, os participantes não deveriam fazer uso regular de medicamento. As amostras foram coletadas em jejum. As amostras foram processadas no equipamento cobas® 6000 (analyser series - Roche Diagnostics), em laboratório da rede DASA na cidade de Cuiabá. Em relação à metodologia estatística, foi analisada a homogeneidade das variâncias através do teste de Bartlett para cada analito por idade e, posteriormente, testados pelo teste ANOVA ou Kruskal-Wallis para verificar a existência de diferença entre as faixas etárias. O teste \"post hocd̈e Bonferroni foi aplicado quando se constatou a diferença para reagrupar as faixas etárias similares, constituindo assim novos grupos etários. Aplicou-se então, o teste de Bartlett e, conforme seu resultado, realizou-se ANOVA ou Kruskal-Wallis para verificar se os agrupamentos nas faixas se mantinham. Em seguida, procedeu-se a exclusão de valores extremos (outiliers) tomados como sendo aqueles valores acima ou abaixo da média ± 3 desvios-padrão. Depois de excluídos os outiliers, obteve-se o IR como sendo a média ± 2 desvios-padrão dos valores remanescentes. Adicionalmente, foi calculada a distribuição em percentis, sendo adotado o critério do NHLBI 2012 como proposta de limite de decisão para a população estudada. Em todos os testes, o nível de significância adotado foi de 5%. As análises estatísticas foram realizadas pelos programas MINITAB (versão 15) e SPSS (versão 16). Este projeto foi aprovado pelas Comitês de Ética em Pesquisa das instituições envolvidas e das Secretarias Municipais de Educação e Saúde de Cuiabá. Os valores encontrados para o colesterol total, nos percentis 75 e 95 foram: 1 a 2 anos de 160 mg/dL e 189 mg/dL; 3 a 8 anos de 170 mg/dL e 199 mg/dL; 9 a 12 anos de 176 mg/dL e 205 mg/dL, respectivamente. Para o colesterol não-HDL, na única faixa etária de 1 a 12 anos, os valores nestes percentis foram de 122 mg/dL e 150 mg/dL, respectivamente. Para o LDL-colesterol, os valores… Advisors/Committee Members: Jacob, Cristina Miuki Abe.

Subjects/Keywords: Adolescent; Adolescente; Child; Cholesterol; Colesterol; Criança; HDL-cholesterol; HDL-colesterol; Intervalos de referência; LDL- colesterol; LDL-cholesterol; Lipídeos; Lipids; Reference intervals; Triglicerídeos; Triglycerides

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Slhessarenko, N. (2014). Determinação dos intervalos de referência do colesterol total, HDL-colesterol, colesterol não HDL, LDL-colesterol e triglicérides em crianças e adolescentes saudáveis do Município de Cuiabá, Mato Grosso, Brasil. (Doctoral Dissertation). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/5/5141/tde-09062014-105138/ ;

Chicago Manual of Style (16^th Edition):

Slhessarenko, Natasha. “Determinação dos intervalos de referência do colesterol total, HDL-colesterol, colesterol não HDL, LDL-colesterol e triglicérides em crianças e adolescentes saudáveis do Município de Cuiabá, Mato Grosso, Brasil.” 2014. Doctoral Dissertation, University of São Paulo. Accessed January 23, 2021. http://www.teses.usp.br/teses/disponiveis/5/5141/tde-09062014-105138/ ;.

MLA Handbook (7^th Edition):

Slhessarenko, Natasha. “Determinação dos intervalos de referência do colesterol total, HDL-colesterol, colesterol não HDL, LDL-colesterol e triglicérides em crianças e adolescentes saudáveis do Município de Cuiabá, Mato Grosso, Brasil.” 2014. Web. 23 Jan 2021.

Vancouver:

Slhessarenko N. Determinação dos intervalos de referência do colesterol total, HDL-colesterol, colesterol não HDL, LDL-colesterol e triglicérides em crianças e adolescentes saudáveis do Município de Cuiabá, Mato Grosso, Brasil. [Internet] [Doctoral dissertation]. University of São Paulo; 2014. [cited 2021 Jan 23]. Available from: http://www.teses.usp.br/teses/disponiveis/5/5141/tde-09062014-105138/ ;.

Council of Science Editors:

Slhessarenko N. Determinação dos intervalos de referência do colesterol total, HDL-colesterol, colesterol não HDL, LDL-colesterol e triglicérides em crianças e adolescentes saudáveis do Município de Cuiabá, Mato Grosso, Brasil. [Doctoral Dissertation]. University of São Paulo; 2014. Available from: http://www.teses.usp.br/teses/disponiveis/5/5141/tde-09062014-105138/ ;

18. Sundberg, Elizabeth E. Macpherson. Effects of hypolipidemic drugs on cellular cholesterol homeostasis in familial hypercholesterolemia.

Degree: PhD, 1989, Oregon Health Sciences University

URL: doi:10.6083/M4RV0KT2 ; http://digitalcommons.ohsu.edu/etd/1898

Subjects/Keywords: Hyperlipoproteinemia Type II; Cholesterol, LDL; Polyamines; Receptors, LDL

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Sundberg, E. E. M. (1989). Effects of hypolipidemic drugs on cellular cholesterol homeostasis in familial hypercholesterolemia. (Doctoral Dissertation). Oregon Health Sciences University. Retrieved from doi:10.6083/M4RV0KT2 ; http://digitalcommons.ohsu.edu/etd/1898

Chicago Manual of Style (16^th Edition):

Sundberg, Elizabeth E Macpherson. “Effects of hypolipidemic drugs on cellular cholesterol homeostasis in familial hypercholesterolemia.” 1989. Doctoral Dissertation, Oregon Health Sciences University. Accessed January 23, 2021. doi:10.6083/M4RV0KT2 ; http://digitalcommons.ohsu.edu/etd/1898.

MLA Handbook (7^th Edition):

Sundberg, Elizabeth E Macpherson. “Effects of hypolipidemic drugs on cellular cholesterol homeostasis in familial hypercholesterolemia.” 1989. Web. 23 Jan 2021.

Vancouver:

Sundberg EEM. Effects of hypolipidemic drugs on cellular cholesterol homeostasis in familial hypercholesterolemia. [Internet] [Doctoral dissertation]. Oregon Health Sciences University; 1989. [cited 2021 Jan 23]. Available from: doi:10.6083/M4RV0KT2 ; http://digitalcommons.ohsu.edu/etd/1898.

Council of Science Editors:

Sundberg EEM. Effects of hypolipidemic drugs on cellular cholesterol homeostasis in familial hypercholesterolemia. [Doctoral Dissertation]. Oregon Health Sciences University; 1989. Available from: doi:10.6083/M4RV0KT2 ; http://digitalcommons.ohsu.edu/etd/1898

19. Padoveze, Amanda Felippe. Cinética plasmática e biodistribuição de colesterol livre e colesterol esterificado de uma nanoemulsão (LDE) que se liga aos receptores de LDL em animais controle e com indução de aterosclerose.

Degree: PhD, Cardiologia, 2007, University of São Paulo

URL: http://www.teses.usp.br/teses/disponiveis/5/5131/tde-25062009-120520/ ;

►

Estudos anteriores em nosso laboratório demonstraram que pacientes portadores de DAC apresentam diferenças no metabolismo do CL e CE de uma nanoemulsão artificial rica em… (more)

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Estudos anteriores em nosso laboratório demonstraram que pacientes portadores de DAC apresentam diferenças no metabolismo do CL e CE de uma nanoemulsão artificial rica em colesterol (LDE), nos quais o CL apresentou maior remoção plasmática e depósito arterial. Dando continuidade a esta linha de pesquisa, neste trabalho foram avaliadas a cinética plasmática, representada pela taxa fracional de remoção (TFR), e a captação do 3H-colesterol livre (3H - CL) e 14C - colesterol esterificado (14C - CE) da LDE por segmentos arteriais e por órgãos de coelhos normais (n=17) e coelhos submetidos à indução de aterosclerose por dieta rica em colesterol (1%) (n=13). Além disso, avaliou-se a captação in vitro do 3H CL e do 14C CE da LDE por células endoteliais aórticas de coelhos. Por último, foi avaliada a influência da inibição da enzima lecitina-colesterol aciltransferase (LCAT), e indiretamente, a esterificação do CL em ratos normais (n=9) e tratados com diazepam (n=9). Em coelhos que receberam dieta normal, não houve diferença entre a remoção plasmática do 3H - CL e do 14C - CE. Em coelhos que desenvolveram hiperlipidemia e aterosclerose através de dieta rica em colesterol, o 3H - CL foi removido mais rapidamente da circulação do que o 14C - CE (p<0,05), entretanto houve maior captação de 14C - CE do que de 3H - CL no arco aórtico (p<0,05). Em ambos os grupos, os principais órgãos captadores de colesterol da LDE foram fígado, pulmão, adrenais e baço (p<0,05). Tanto a TRF quanto a captação hepática de 3H - CL e 14C - CE foram menores no grupo que recebeu a dieta rica em colesterol. Em células endoteliais aórticas de coelhos, a captação de 3H - CL foi maior que a de 14C CE independente da massa de LDE incubada (p<0,01). Em ratos, não houve diferença entre a captação das duas formas de colesterol da LDE pela aorta no grupo controle, entretanto, quando a atividade da LCAT foi diminuída pelo tratamento com diazepam, a captação arterial de 3H - CL foi maior do que a de 14C - CE (p< 0,01). A hiperlipidemia e distúrbios no processo de estabilização do colesterol, favorecem a dissociação entre o CL e o CE das lipoproteínas, e podem elevar o risco de desenvolvimento da aterosclerose, assim como agravar o processo de aterogênese.

I n previously studies, it was shown that free cholesterol (FC) and cholesterol ester (CE) of a cholesterol-rich nanoemulsion (LDE) behaves differently in patients with coronary artery disease (CAD). The FC plasma clearance and arterial deposition is greater than CE. In the present study we evaluate the plasma kinetics, estimated by the fractional clearance rate (FCR), and the tissue uptake of 3H-free cholesterol (3H FC) and of 14C cholesterol ester (14C - CE) of LDE by arterial segments and organs of rabbits with (n=13) and without atherosclerosis (n=17). Furthermore, it was evaluated the in vitro uptake of 3H FC and 14C - CE by rabbit aortic endothelial cells. Finally, it was evaluated the inhibition of the enzyme lecithin-cholesterol acyltransferase (LCAT), and indirectly, the FC esterification in…

Advisors/Committee Members: Maranhao, Raul Cavalcante.

Subjects/Keywords: Animal models; Aterosclerose; Atherosclerosis; Cholesterol; Cinética; Colesterol; Emulsions; Emulsões; Kinetics; LDL lipoproteins; Lipoproteínas LDL; Modelos animais

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Padoveze, A. F. (2007). Cinética plasmática e biodistribuição de colesterol livre e colesterol esterificado de uma nanoemulsão (LDE) que se liga aos receptores de LDL em animais controle e com indução de aterosclerose. (Doctoral Dissertation). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/5/5131/tde-25062009-120520/ ;

Chicago Manual of Style (16^th Edition):

Padoveze, Amanda Felippe. “Cinética plasmática e biodistribuição de colesterol livre e colesterol esterificado de uma nanoemulsão (LDE) que se liga aos receptores de LDL em animais controle e com indução de aterosclerose.” 2007. Doctoral Dissertation, University of São Paulo. Accessed January 23, 2021. http://www.teses.usp.br/teses/disponiveis/5/5131/tde-25062009-120520/ ;.

MLA Handbook (7^th Edition):

Padoveze, Amanda Felippe. “Cinética plasmática e biodistribuição de colesterol livre e colesterol esterificado de uma nanoemulsão (LDE) que se liga aos receptores de LDL em animais controle e com indução de aterosclerose.” 2007. Web. 23 Jan 2021.

Vancouver:

Padoveze AF. Cinética plasmática e biodistribuição de colesterol livre e colesterol esterificado de uma nanoemulsão (LDE) que se liga aos receptores de LDL em animais controle e com indução de aterosclerose. [Internet] [Doctoral dissertation]. University of São Paulo; 2007. [cited 2021 Jan 23]. Available from: http://www.teses.usp.br/teses/disponiveis/5/5131/tde-25062009-120520/ ;.

Council of Science Editors:

Padoveze AF. Cinética plasmática e biodistribuição de colesterol livre e colesterol esterificado de uma nanoemulsão (LDE) que se liga aos receptores de LDL em animais controle e com indução de aterosclerose. [Doctoral Dissertation]. University of São Paulo; 2007. Available from: http://www.teses.usp.br/teses/disponiveis/5/5131/tde-25062009-120520/ ;

20. Vargas, Bianca Languer. Ação do camu-camu [Myrciaria dubia (Kunth) McVaugh] liofilizado sobre a glicemia e o perfil lipídico de adultos jovens.

Degree: 2012, Universidade Federal do Amazonas

URL: http://tede.ufam.edu.br/handle/tede/4267

►

As doenças crônicas, como diabetes, doenças cardiovasculares (DCV) e câncer, representam atualmente 60% de todas as mortes no mundo. O estresse oxidativo, desencadeado pela ação… (more)

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As doenças crônicas, como diabetes, doenças cardiovasculares (DCV) e câncer, representam atualmente 60% de todas as mortes no mundo. O estresse oxidativo, desencadeado pela ação de radicais livres, está envolvido na patogênese de inúmeras doenças crônicas, a exemplo as DCV. Alguns nutrientes presentes em frutas e verduras possuem ação antioxidante, como é o caso dos flavonóides e da vitamina C, e seu consumo regular está associado à diminuição do risco de desenvolvimento de doenças crônicas. O camu-camu [Myrciaria dubia (Kunth) McVaugh] é um fruto exclusivo da região amazônica que possui teores significativos de antioxidantes, principalmente vitamina C e flavonóides. O presente trabalho teve como objetivo avaliar o efeito do pó da polpa de camu-camu sobre a glicemia e o perfil lipídico de adultos jovens. A polpa do camu-camu foi liofilizada e sua composição nutricional foi analisada utilizando-se os métodos indicados pelo Instituto Adolpho Lutz para a composição centesimal e o método de CLAE para vitamina C. Para a intervenção, foi conduzido um ensaio clínico controlado, duplo-cego, em 18 voluntários de ambos os gêneros, com idades entre 21 e 35 anos. Os participantes foram divididos em dois grupos: 1) grupo intervenção, que recebeu cápsulas de camu-camu liofilizado contendo 320 mg de vitamina C; 2) grupo controle, que recebeu cápsulas contendo 320 mg vitamina C sintética. A ingestão das cápsulas foi diária durante 15 dias e duas coletas de sangue foram procedidas, uma antes do início do estudo e outra ao final. Foram verificadas as diferenças estatísticas nos níveis de vitamina C no plasma, glicemia de jejum e perfil lipídico por meio do Teste t de Student. O camu-camu liofilizado apresentou 20.310 mg de vitamina C/100g e 12,89 mg de flavonóides/100g. Ao final da intervenção registrou-se queda significativa nos níveis de glicemia de jejum, colesterol total e HDL (p<0,05) no grupo que recebeu cápsulas de camu-camu e redução significativa apenas da glicemia de jejum (p<0,05) no grupo que recebeu cápsulas de vitamina C sintética. Quando avaliados somente aqueles indivíduos que seguiram corretamente o protocolo, observou-se diminuição significativa também nos valores de LDL (p<0,05) no grupo intervenção. Em ambos os grupos houve tendência de redução nos níveis de triglicerídeos, porém não significativa (p>0,05). Conclui-se que as cápsulas de camu-camu foram mais eficientes, apresentando ação hipolipidêmica e hipoglicemiante nos voluntários estudados. Tais resultados demonstram o potencial benéfico da vitamina C e do camu-camu à saúde, apresentando o fruto como uma excelente fonte desta vitamina.

Currently, chronic diseases such as diabetes, cardiovascular disease (CVD) and cancer account for 60% of all deaths worldwide. Oxidative stress caused by the action of free radicals is involved in the pathogenesis of many chronic diseases such as CVD. Flavonoids and vitamin C are antioxidant nutrients found in fruits and vegetables, and its regular consumption is associated with decreased risk of developing chronic diseases.…

Advisors/Committee Members: Yuyama, Lúcia Kiyoko Ozaki, 833.757.168-34, http://lattes.cnpq.br/2466776830720833, Souza, Francisca das Chagas do Amaral, 436.947.052-87, http://lattes.cnpq.br/4281093837396621, Carvalho, Rosany Piccolotto, Teixeira, Maria Francisca Simas, Barbosa, Keillah Mara do Nascimento.

Subjects/Keywords: Vitamina C; Flavonóides; LDL-colesterol; Vitamin C; Flavonoids; LDL-cholesterol; CIÊNCIAS AGRÁRIAS: CIÊNCIA E TECNOLOGIA DE ALIMENTOS: CIÊNCIA DE ALIMENTOS

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Vargas, B. L. (2012). Ação do camu-camu [Myrciaria dubia (Kunth) McVaugh] liofilizado sobre a glicemia e o perfil lipídico de adultos jovens. (Masters Thesis). Universidade Federal do Amazonas. Retrieved from http://tede.ufam.edu.br/handle/tede/4267

Chicago Manual of Style (16^th Edition):

Vargas, Bianca Languer. “Ação do camu-camu [Myrciaria dubia (Kunth) McVaugh] liofilizado sobre a glicemia e o perfil lipídico de adultos jovens.” 2012. Masters Thesis, Universidade Federal do Amazonas. Accessed January 23, 2021. http://tede.ufam.edu.br/handle/tede/4267.

MLA Handbook (7^th Edition):

Vargas, Bianca Languer. “Ação do camu-camu [Myrciaria dubia (Kunth) McVaugh] liofilizado sobre a glicemia e o perfil lipídico de adultos jovens.” 2012. Web. 23 Jan 2021.

Vancouver:

Vargas BL. Ação do camu-camu [Myrciaria dubia (Kunth) McVaugh] liofilizado sobre a glicemia e o perfil lipídico de adultos jovens. [Internet] [Masters thesis]. Universidade Federal do Amazonas; 2012. [cited 2021 Jan 23]. Available from: http://tede.ufam.edu.br/handle/tede/4267.

Council of Science Editors:

Vargas BL. Ação do camu-camu [Myrciaria dubia (Kunth) McVaugh] liofilizado sobre a glicemia e o perfil lipídico de adultos jovens. [Masters Thesis]. Universidade Federal do Amazonas; 2012. Available from: http://tede.ufam.edu.br/handle/tede/4267

21. Muramoto, Giovana. Avaliação nutricional e do perfil lipídico de crianças e adolescentes, com processo inflamatório, em unidade de emergência de um hospital universitário.

Degree: Mestrado, Pediatria, 2015, University of São Paulo

URL: http://www.teses.usp.br/teses/disponiveis/5/5141/tde-20052015-104110/ ;

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Objetivo: comparar o perfil lipídico de em crianças e adolescentes, com e sem inflamação, atendidas num pronto atendimento geral de pediatria de um hospital universitário… (more)

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Objetivo: comparar o perfil lipídico de em crianças e adolescentes, com e sem inflamação, atendidas num pronto atendimento geral de pediatria de um hospital universitário de nível de atendimento secundário, segundo estado nutricional, sexo e idade. Métodos: Estudo transversal, realizado entre outubro de 2012 e agosto de 2013, avaliou 124 crianças e adolescentes (3 meses a 14 anos de idade) em atendimento na unidade de emergência do Hospital Universitário da Universidade de São Paulo, com queixa relacionada a processo inflamatório/infeccioso. Os pacientes foram separados em dois grupos de acordo com os níveis de proteína C reativa (PCR): grupo I se maior ou igual a 5 mg/L, e grupo II se menor que 5mg/L. Dosagens de colesterol total, lipoproteína de alta densidade (HDL) e baixa densidade (LDL), triglicerídeos e albumina foram comparadas entre os dois grupos, levando em conta o estado nutricional (avaliado através de medidas antropométricas), gênero e idade. Resultado: A mediana de idade foi de 51 meses, com maioria dos pacientes classificados como eutróficos (76,5%). Do total da amostra, 34,7% dos pacientes apresentaram colesterol total e/ou triglicerídeos alterados e 67% apresentaram baixos níveis de HDL. Não houve diferença significativa do perfil lipídico entre os dois grupos de pacientes separados de acordo com PCR. Dentre os pacientes com PCR >= 5mg/L, a PCR apresentou correlação inversa com HDL [r= (-)0,363 e p=0,001], com LDL [r= (-) 0,235 e p=0,034], com albumina [r= (-) 0,308 e p=0,005] e correlação direta com TG (r=0,426 e p > 0,001). Na analise de regressão linear, se evidenciou que para cada aumento de 1mg/L nos valores da PCR espera-se uma redução média de 0,072 mg/dL da HDL, de 0,083 mg/dL da LDL, de 0,002g/dL de albumina, e um aumento médio de 0,564 mg/dL do triglicerídeo. Conclusão: Pacientes com processo inflamatório apresentam alterações nos níveis séricos do HDL, LDL e triglicerídeos que se relacionam com o grau de inflamação, de forma independente do estado nutricional

Aim: To compare the lipid profile in children and adolescents with and without inflammation, met a ready general pediatric service of a university hospital secondary care level, according to nutritional status, gender and age. Methods: Cross-sectional study conducted between October 2012 and August 2013, assessed 124 children and adolescents (3 months to 14 years old) in the emergency department of the University Hospital of the University of São Paulo, with reports of inflammatory/ infectious process. The patients were divided into two groups according to the C reactive protein (CRP) levels: group I is higher than or equal to 5 mg/L, and Group II was lower than 5 mg/L. Total cholesterol, high density lipoprotein (HDL) and low density lipoprotein (LDL), triglycerides and albumin were compared between the two groups, taking into account the nutritional status (assessed by anthropometric measurements), gender and age. Results: The median age was 51 months, with patients mostly classified as well-nourished (76.5%). Of the overall…

Advisors/Committee Members: Delgado, Artur Figueiredo.

Subjects/Keywords: Adolescent; Adolescente; C-reactive protein; Child; Cholesterol LDL; Colesterol; Criança; Emergency medical services, Nutritional status; Estado nutricional; Fats; Gorduras; HDL-colesterol; Infecção; Inflamação; Inflammation, Infection; LDL Cholesterol; LDL-colesterol; Lipídeos; Lipids; Lipoproteínas; Lipoproteínas HDL; Lipoproteínas LDL; Lipoproteins; Lipoproteins HDL; Lipoproteins LDL, Cholesterol HDL; Proteína C-reativa; Serviços médicos de emergência

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Muramoto, G. (2015). Avaliação nutricional e do perfil lipídico de crianças e adolescentes, com processo inflamatório, em unidade de emergência de um hospital universitário. (Masters Thesis). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/5/5141/tde-20052015-104110/ ;

Chicago Manual of Style (16^th Edition):

Muramoto, Giovana. “Avaliação nutricional e do perfil lipídico de crianças e adolescentes, com processo inflamatório, em unidade de emergência de um hospital universitário.” 2015. Masters Thesis, University of São Paulo. Accessed January 23, 2021. http://www.teses.usp.br/teses/disponiveis/5/5141/tde-20052015-104110/ ;.

MLA Handbook (7^th Edition):

Muramoto, Giovana. “Avaliação nutricional e do perfil lipídico de crianças e adolescentes, com processo inflamatório, em unidade de emergência de um hospital universitário.” 2015. Web. 23 Jan 2021.

Vancouver:

Muramoto G. Avaliação nutricional e do perfil lipídico de crianças e adolescentes, com processo inflamatório, em unidade de emergência de um hospital universitário. [Internet] [Masters thesis]. University of São Paulo; 2015. [cited 2021 Jan 23]. Available from: http://www.teses.usp.br/teses/disponiveis/5/5141/tde-20052015-104110/ ;.

Council of Science Editors:

Muramoto G. Avaliação nutricional e do perfil lipídico de crianças e adolescentes, com processo inflamatório, em unidade de emergência de um hospital universitário. [Masters Thesis]. University of São Paulo; 2015. Available from: http://www.teses.usp.br/teses/disponiveis/5/5141/tde-20052015-104110/ ;

22. Silva, Jeferson Luis da. Os efeitos do exercício resistido no metabolismo da lipoproteína de baixa densidade (LDL) e da lipoproteína de alta densidade (HDL), utilizando uma nanoemulsão semelhante a LDL.

Degree: PhD, Cardiologia, 2011, University of São Paulo

URL: http://www.teses.usp.br/teses/disponiveis/5/5131/tde-23112011-185508/ ;

►

Treinamento físico é considerado um dos principais instrumentos para promover um estilo de vida saudável. No entanto, os efeitos do treinamento resistido sobre as vias… (more)

▼

Treinamento físico é considerado um dos principais instrumentos para promover um estilo de vida saudável. No entanto, os efeitos do treinamento resistido sobre as vias metabólicas, especialmente o metabolismo lipídico intravascular é em grande parte inexplorada e merece uma investigação mais aprofundada. No presente estudo nós avaliamos os efeitos do treinamento resistido sobre o metabolismo de uma nanoemulsão artificial lipídica e na transferência de lípides para HDL, uma importante etapa do metabolismo da HDL. A cinética plasmática da nanoemulsão artificial lipídica foi estudada em 15 homens saudáveis com treinamento resistido regular de 1-4 anos (idade = 25 ± 5 anos, VO2máx = 50 ± 6 mL/kg/min) e em 15 homens saudáveis sedentários (28 ± 7 anos, VO2máx = 35 ± 9 mL/kg/min). A nanoemulsão artificial lipídica marcada com éster de colesterol-14C e colesterol livre-3H foi injetada por via intravenosa, as amostras de plasma foram coletadas por 24 h para determinar curvas de cinéticas e a taxa fracional de remoção (TFR). Transferência de lípides para HDL foi determinada in vitro pela incubação de amostras de plasma com nanoemulsões (doadores de lípides) marcada com o isótopo radioativo colesterol livre, éster de colesterol, triglicérides e fosfolípides. Tamanho da HDL, atividade da paraoxonase 1 e os níveis de LDL oxidada também foram determinadas. Os dois grupos apresentaram LDL-colesterol, HDL-colesterol e triglicérides semelhantes, mas a LDL oxidada foi menor no grupo treinamento resistido (30 ± 9 vs 61 ± 19 U/L, p = 0,0005). No treinamento resistido, a nanoemulsão éster de colesterol-14C foi removida duas vezes mais rápido do que em indivíduos sedentários (TFR: 0,068 ± 0,023 vs 0,037 ± 0,028, p = 0,002), bem como o colesterol livre-3H (0,041 ± 0,025 vs 0,022 ± 0,023, p = 0,04). Embora ambos os componentes da nanoemulsão tenham sido removidos na mesma proporção em indivíduos sedentários, no grupo treinamento resistido o colesterol livre-3H foi removido mais lento do que o éster de colesterol-14C (p = 0,005). Tamanho da HDL, paraoxonase 1 e as taxas de transferência de HDL dos quatro lipídios foram as mesmas em ambos os grupos. Portanto, concluímos que o treinamento resistido acelera a remoção da nanoemulsão artificial lipídica, o que provavelmente explica a redução dos níveis de LDL oxidada no grupo treinamento resistido. O treinamento resistido também alterou o equilíbrio da TFR do colesterol livre e esterificado. No entanto, o treinamento resistido não teve efeito nos parâmetros relacionados ao metabolismo da HDL

Exercise training is considered one of the main instruments to promote a healthy lifestyle. However, effects resistance training on the metabolic pathways, specially the intravascular lipid metabolism is largely unexplored and deserves further investigation. In this study we evaluated the effects of resistance training on the metabolism of an LDL-like nanoemulsion and on lipid transfer to HDL, an important step of HDL metabolism. LDL-like nanoemulsion plasma kinetics was studied in 15 healthy men under…

Advisors/Committee Members: Vinagre, Carmen Guilherme Christiano de Matos.

Subjects/Keywords: Cholesterol HDL/metabolism; Cholesterol LDL/metabolism; Colesterol HDL/metabolismo; Colesterol LDL/metabolismo; Exercício; Exercise; Lípideos; Lipids; Lipoproteínas; Lipoproteins; Nanoparticles; Nanopartículas; Resistance training; Treinamento resistido

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Silva, J. L. d. (2011). Os efeitos do exercício resistido no metabolismo da lipoproteína de baixa densidade (LDL) e da lipoproteína de alta densidade (HDL), utilizando uma nanoemulsão semelhante a LDL. (Doctoral Dissertation). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/5/5131/tde-23112011-185508/ ;

Chicago Manual of Style (16^th Edition):

Silva, Jeferson Luis da. “Os efeitos do exercício resistido no metabolismo da lipoproteína de baixa densidade (LDL) e da lipoproteína de alta densidade (HDL), utilizando uma nanoemulsão semelhante a LDL.” 2011. Doctoral Dissertation, University of São Paulo. Accessed January 23, 2021. http://www.teses.usp.br/teses/disponiveis/5/5131/tde-23112011-185508/ ;.

MLA Handbook (7^th Edition):

Silva, Jeferson Luis da. “Os efeitos do exercício resistido no metabolismo da lipoproteína de baixa densidade (LDL) e da lipoproteína de alta densidade (HDL), utilizando uma nanoemulsão semelhante a LDL.” 2011. Web. 23 Jan 2021.

Vancouver:

Silva JLd. Os efeitos do exercício resistido no metabolismo da lipoproteína de baixa densidade (LDL) e da lipoproteína de alta densidade (HDL), utilizando uma nanoemulsão semelhante a LDL. [Internet] [Doctoral dissertation]. University of São Paulo; 2011. [cited 2021 Jan 23]. Available from: http://www.teses.usp.br/teses/disponiveis/5/5131/tde-23112011-185508/ ;.

Council of Science Editors:

Silva JLd. Os efeitos do exercício resistido no metabolismo da lipoproteína de baixa densidade (LDL) e da lipoproteína de alta densidade (HDL), utilizando uma nanoemulsão semelhante a LDL. [Doctoral Dissertation]. University of São Paulo; 2011. Available from: http://www.teses.usp.br/teses/disponiveis/5/5131/tde-23112011-185508/ ;

23. Rodrigues, Alina Coutinho. Avaliação do metabolismo de lipídes em diabéticos tipo 1, normolipidêmicos e sem complicações microvasculares e macrovasculares significativas através de nanoemulsão lipídica artificial.

Degree: PhD, Endocrinologia, 2008, University of São Paulo

URL: http://www.teses.usp.br/teses/disponiveis/5/5135/tde-15062009-125934/ ;

► INTRODUÇÃO: portadores de diabetes mellitus tipo 1 (DM1) apresentam, progressivamente, complicações vásculo-neurais. Os fatores que aumentam o risco de coronariopatia - hipertensão, dislipidemia e idade… (more)

▼ INTRODUÇÃO: portadores de diabetes mellitus tipo 1 (DM1) apresentam, progressivamente, complicações vásculo-neurais. Os fatores que aumentam o risco de coronariopatia - hipertensão, dislipidemia e idade avançada - explicam, em parte, a alta mortalidade cardiovascular, entretanto diabéticos tipo 1 podem morrer de coronariopatia precoce e não apresentar os fatores de risco clássicos para aterosclerose. Modificações estruturais e funcionais nas lipoproteínas, alterando a sua composição e trocas lipídicas poderiam justificar o aumento de eventos vasculares, entretanto estas alterações podem não ser detectadas através das dosagens rotineiras de lípides plasmáticos. OBJETIVOS: através de nanoemulsão lipídica artificial (LDE) que simula a estrutura lipídica da LDL avaliamos, em portadores de DM1, normolipidêmicos, intensivamente tratados e sem complicações significativas da doença, a taxa de esterificação do colesterol, a remoção da nanoemulsão da circulação, o tamanho da partícula HDL e as transferências de lípides entre a nanoemulsão e as partículas HDL. Secundariamente, determinamos a influência do controle glicêmico, resistência à insulina (RI) e insulinização no metabolismo lipídico. MÉTODOS: estudamos 36 indivíduos diabéticos e 37 controles não-diabéticos pareados para idade, sexo e índice de massa corpórea. Nanoemulsão lipídica artificial com marcação radioativa nos lípides éster de colesterol (CE), colesterol livre (CL), triglicérides (TG) e fosfolípides (PL) foi utilizada para os estudos. Nanoemulsão com marcação 14C-CE e 3H-CL foi injetada nos participantes e amostras de sangue foram coletadas durante 24 horas para mensuração da radioatividade. Remoção dos lípides da circulação foi calculada por análise compartimental. A taxa da esterificação do colesterol livre foi calculada após extração e separação de lípides do plasma por cromatografia em camada delgada. Para estudo da transferência de lípides, nanoemulsões com marcação 14C-CE e 3H-CL ou 14C-PL e 3H-TG foram incubadas com plasma e a radioatividade dos lípides transferidos para as HDL foi contada após a precipitação de lipoproteínas contendo apoB. O diâmetro da HDL foi mensurado por método de dispersão da luz. A RI nos diabéticos foi mensurada por fórmula que estima a taxa de captação da glicose. RESULTADOS: hemoglobina glicada foi de 8,8±1,3 mg/dl e concentrações de LDLc foram menores nos diabéticos (85±22 vs. 98±26 mg/dl), p=0, 035. Não houve diferenças em relação às taxas de esterificação, transferências de lípides da nanoemulsão para as HDL e tamanho da partícula HDL entre os grupos. Não encontramos relação entre as análises cinéticas e HbA1c, glicemia, índices de RI e dose de insulina. A taxa de remoção do 14C-CE foi mais rápida em diabéticos tipo 1 que nos controles (0, 059±0, 022 vs.0, 039±0, 022 h-1), p=0, 019. 16 CONCLUSÕES: apesar de controle glicêmico ruim nos DM1, as transferências de lípides da nanoemulsão para as HDL, a taxa de esterificação e a remoção da 3H-CL são semelhantes às dos controles. O controle glicêmico, perfil lipídico, índices de RI… Advisors/Committee Members: Wajchenberg, Bernardo Leo.

Subjects/Keywords: Aterosclerose; Atherosclerosis; Cinética; Colesterol HDL; Colesterol LDL; Diabetes mellitus tipo 1; HDL cholesterol; Insulin; Insulina; Kinetic; LDL cholesterol; Lipoprotein; Lipoproteínas; Type 1 diabetes mellitus

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Rodrigues, A. C. (2008). Avaliação do metabolismo de lipídes em diabéticos tipo 1, normolipidêmicos e sem complicações microvasculares e macrovasculares significativas através de nanoemulsão lipídica artificial. (Doctoral Dissertation). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/5/5135/tde-15062009-125934/ ;

Chicago Manual of Style (16^th Edition):

Rodrigues, Alina Coutinho. “Avaliação do metabolismo de lipídes em diabéticos tipo 1, normolipidêmicos e sem complicações microvasculares e macrovasculares significativas através de nanoemulsão lipídica artificial.” 2008. Doctoral Dissertation, University of São Paulo. Accessed January 23, 2021. http://www.teses.usp.br/teses/disponiveis/5/5135/tde-15062009-125934/ ;.

MLA Handbook (7^th Edition):

Rodrigues, Alina Coutinho. “Avaliação do metabolismo de lipídes em diabéticos tipo 1, normolipidêmicos e sem complicações microvasculares e macrovasculares significativas através de nanoemulsão lipídica artificial.” 2008. Web. 23 Jan 2021.

Vancouver:

Rodrigues AC. Avaliação do metabolismo de lipídes em diabéticos tipo 1, normolipidêmicos e sem complicações microvasculares e macrovasculares significativas através de nanoemulsão lipídica artificial. [Internet] [Doctoral dissertation]. University of São Paulo; 2008. [cited 2021 Jan 23]. Available from: http://www.teses.usp.br/teses/disponiveis/5/5135/tde-15062009-125934/ ;.

Council of Science Editors:

Rodrigues AC. Avaliação do metabolismo de lipídes em diabéticos tipo 1, normolipidêmicos e sem complicações microvasculares e macrovasculares significativas através de nanoemulsão lipídica artificial. [Doctoral Dissertation]. University of São Paulo; 2008. Available from: http://www.teses.usp.br/teses/disponiveis/5/5135/tde-15062009-125934/ ;

University of Oulu

24. Hyttinen, L. (Laura). Long-term effects of the cholesterol level and its drug treatment.

Degree: 2011, University of Oulu

URL: http://urn.fi/urn:isbn:9789514296222

►

Abstract Increased plasma cholesterol is a well-known risk factor for cardiovascular diseases in middle and early old age. At older ages, this association seems to… (more)

▼

Abstract Increased plasma cholesterol is a well-known risk factor for cardiovascular diseases in middle and early old age. At older ages, this association seems to disappear. Very few studies have assessed the impact of the lifelong cholesterol burden on old age, the purpose of this thesis. Study populations consisted of 1) old persons with familial hypercholesterolemia (FH), a genetic disorder associated with an increased risk of coronary heart disease (CHD) if untreated, and 2) initially healthy men (The Helsinki Businessmen Study, HBS) followed-up from midlife to old age. A population-based FH cohort, aged ≥ 65 years (n=37, aged 65 to 84 years) agreed to participate in this study. All but one of them had been using statin therapy for approx. 15 years. Variables studied were: health-related quality of life (HRQoL) with questionnaires (RAND-36, 15D), a brain magnetic resonance imaging (MRI) scan and cognitive tests (CERAD). These older FH patients enjoyed a similar HRQoL as controls in the general population. Only two (6%) of the older FH patients had clinically silent brain infarcts detected by MRI and those aged 65 to 74 years did not have more white matter hyperintensities (WMHIs) when compared to middle-aged controls. In the cognitive assessments, FH patients, especially those with duration of statin therapy longer than median, even expressed better episodic memory than population controls. HBS consists of a cohort of men (3277 men) who at baseline (1964–1973) were healthy and in their 40s. They were subdivided into seven groups according to baseline total cholesterol value at 1 mmol/L intervals starting from ≤ 4 mmol/L. In 2000, at a mean age of 73 years, they filled a postal questionnaire including RAND-36. Cumulative mortality data were collected up to January 2010. A strong and graded relation was found between the cholesterol level and total mortality, those men with a cholesterol level ≤ 4 mmol/L exhibiting the lowest mortality. A low cholesterol value at midlife also predicted a better score in the Physical functioning scale of RAND-36 in old age. In conclusion, in initially healthy men, a low cholesterol value at midlife was associated with better survival and better physical function in old age. Despite their genetic risk, FH patients on long-term statin medication seemed to enjoy a health and cognitive status similar to the general population.

Tiivistelmä Suurentunut plasman kolesterolipitoisuus on tunnettu valtimotautien riskitekijä keski-iässä, mutta vanhuusiässä kolesterolin merkitys näyttää vähentyvän. Hyvin harvassa tutkimuksessa on tutkittu elämänaikaisen kolesterolitason vaikutuksia vanhuusiän terveydentilaan, kuten tässä väitöskirjatyössä. Tutkimuskohteina olivat 1) iäkkäät, joilla on familiaalinen hyperkolesterolemia (FH) eli perinnöllinen sairaus, johon hoitamattomana liittyy lisääntynyt sepelvaltimotaudin riski, sekä 2) alun perin terveet miehet (Helsingin Johtajatutkimus), joita seurattiin keski-iästä vanhuuteen. Väestöpohjainen, 65 vuotta…

Advisors/Committee Members: Strandberg, T. (Timo E.), Vuorio, A. (Alpo F.).

Subjects/Keywords: brain infarction; cholesterol; cholesterol LDL; hypercholesterolemia; hyperlipoproteinemia type II; magnetic resonance imaging; quality of life; LDL-kolesteroli; aivoinfarkti; elämänlaatu; hyperkolesterolemia; kolesteroli; magneettikuvaus; tyypin II hyperlipoproteinemia

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Hyttinen, L. (. (2011). Long-term effects of the cholesterol level and its drug treatment. (Doctoral Dissertation). University of Oulu. Retrieved from http://urn.fi/urn:isbn:9789514296222

Chicago Manual of Style (16^th Edition):

Hyttinen, L (Laura). “Long-term effects of the cholesterol level and its drug treatment.” 2011. Doctoral Dissertation, University of Oulu. Accessed January 23, 2021. http://urn.fi/urn:isbn:9789514296222.

MLA Handbook (7^th Edition):

Hyttinen, L (Laura). “Long-term effects of the cholesterol level and its drug treatment.” 2011. Web. 23 Jan 2021.

Vancouver:

Hyttinen L(. Long-term effects of the cholesterol level and its drug treatment. [Internet] [Doctoral dissertation]. University of Oulu; 2011. [cited 2021 Jan 23]. Available from: http://urn.fi/urn:isbn:9789514296222.

Council of Science Editors:

Hyttinen L(. Long-term effects of the cholesterol level and its drug treatment. [Doctoral Dissertation]. University of Oulu; 2011. Available from: http://urn.fi/urn:isbn:9789514296222

NSYSU

25. Chiang, Hsiao-chiu. Efficacy and safety of 20mg simvastatin treatment in hypercholesterolemia: a 12-week study.

Degree: Master, Institute of Biomedical Sciences, 2006, NSYSU

URL: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0823106-162536

► Background. The published reports of the effectiveness of simvastatin in treatment of hypercholesterolemia were mostly conducted in western populations, and only few studies in Asian… (more)

▼ Background. The published reports of the effectiveness of simvastatin in treatment of hypercholesterolemia were mostly conducted in western populations, and only few studies in Asian or domestic populations have ever been reported. By regulations from Bureau of National Health Insurance, the effective dosage of lipid lowering agents should be started from lower dose, such as 20 mg of simvastatin per day. Whether this dosage of simvastatin is effective for treatment of patients with hypercholesterolemia and the efficacy and safety of such dosage are the objects of this study. Materials and Methods. After the approval of IRB in a medical center located at north Taiwan, a randomized 12-week study was conducted to evaluate the efficacy and safety of 20mg/day simvastatin treatment on hypercholesterolemia. By randomization 65 patients, followed up at cardiovascular outpatient department under the diagnosis of primary hypercholesterolemia, were enrolled into a 4-week washout period, and finally 49 intent-to-treat patients entered a 12-week treatment with 20mg simvastatin per day, given through oral routine in the evening. Demographic and laboratory data were obtained before and after treatment. The primary efficacy measure was the changes from baseline in lipid parameters. Tolerability was assessed in terms of the overall incidence of adverse experiences and the most commonly reported adverse experiences. Results. The per-protocol analyses included 39 hypercholesterolemic patients whom completed 12 weeks of therapy. Total cholesterol and LDL cholesterol at the end of the study period showed significant reductions by 22.5ï¼ (p<0.001) and 29.8ï¼(p<0.001), respectively. Triglyceride also showed a significant reduction by 31.8% (p=0.006), whereas total alkaline phosphatase and calcium showed a weak and insignificant change over the study period. The female group had significantly greater reduction in triglyceride than that in the male group, and the non-smoking group also had significantly greater reduction in triglyceride than that in smoking group after 12-week treatment. There were 17 studied cases (34.7%) had minor transient but clinical insignificant increases in serum aspartate aminotransferase and alanine aminotransferase, and 7 cases (14.3%) experienced symptom of painful muscle, of whom 3 cases (6.1%) dropped out this study. Conclusion. Our results, although obtained from a small scale of hypercholesterolemic patients, suggest a probable positive efficacy and good tolerability with only few minor side effects of simvastatin on blood lipids. Advisors/Committee Members: Ming-jen Yang (committee member), SJ Hwang (chair), WC Hung (chair).

Subjects/Keywords: hypercholesterolemia; simvastatin; LDL; HDL; triglyceride; cholesterol

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Chiang, H. (2006). Efficacy and safety of 20mg simvastatin treatment in hypercholesterolemia: a 12-week study. (Thesis). NSYSU. Retrieved from http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0823106-162536

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Chiang, Hsiao-chiu. “Efficacy and safety of 20mg simvastatin treatment in hypercholesterolemia: a 12-week study.” 2006. Thesis, NSYSU. Accessed January 23, 2021. http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0823106-162536.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Chiang, Hsiao-chiu. “Efficacy and safety of 20mg simvastatin treatment in hypercholesterolemia: a 12-week study.” 2006. Web. 23 Jan 2021.

Vancouver:

Chiang H. Efficacy and safety of 20mg simvastatin treatment in hypercholesterolemia: a 12-week study. [Internet] [Thesis]. NSYSU; 2006. [cited 2021 Jan 23]. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0823106-162536.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Chiang H. Efficacy and safety of 20mg simvastatin treatment in hypercholesterolemia: a 12-week study. [Thesis]. NSYSU; 2006. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0823106-162536

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

UCLA

26. Chotivichien, Saipin. Effect of nutritional counseling on low-density lipoprotein (LDL) cholesterol among Thai HIV-infected adults receiving antiretroviral therapy.

Degree: Epidemiology, 2013, UCLA

URL: http://www.escholarship.org/uc/item/9w04j709

► Background: Although intensive antiretroviral therapies dramatically reduce mortality rates in HIV-infected patients, significant metabolic complications associated with antiretroviral therapy including dyslipidemia have been increasingly reported.… (more)

▼ Background: Although intensive antiretroviral therapies dramatically reduce mortality rates in HIV-infected patients, significant metabolic complications associated with antiretroviral therapy including dyslipidemia have been increasingly reported. Objectives of this study are to determine 1) an effect of individual nutritional counseling on dyslipidemia, particularly LDL-C, among Thai HIV-infected adults with dyslipidemia who were not currently taking lipid-lowering medication 2) predictors of reducing LDL-C in Thai HIV-infected adults receiving a stable of antiretroviral regimen for at least 3 months. Methods: We conducted a randomized, 24-week study in HIV-infected patients who were on antiretroviral therapy with dyslipidemia and were eligible to initiate therapeutic lifestyle changes according to National Cholesterol Education Program (2002). Participants were randomly assigned into two groups. The intervention group received individual counseling with a nutritionist whereas the control group received general diet advice from a physician. A 24-hr recall technique was used to assess dietary intake for both groups at baseline and at week 24. Lipid profile was measured at baseline, at 12 weeks and 24 weeks of follow up. Predictors (measured at baseline) associated with the reduction of LDL-C in HIV-infected patients were assessed for any reduction in LDL-C and for a reduction of at least 10 mg/dL. Results: Seventy-two patients were randomly assigned. Of these, 62 (86%) completed lipid profile testing and 59 (82%) completed dietary interview. We found a significant difference in mean reduction from baseline of total cholesterol (8% vs 0%) and LDL-C (13% vs 4%) between the intervention group and the control group at week 24. A significant reduction in weight and in carbohydrate intake in the intervention group was observed. Participants who had good level of knowledge of dyslipidemia were more likely to achieve reduction in LDL-C of at least 10 mg/dL at 24 weeks of follow up. Conclusions: The effectiveness of individual nutritional counseling in improving dyslipidemia, particularly total cholesterol and LDL-C, among Thai HIV-infected adults with dyslipidemia receiving antiretroviral therapy has been demonstrated. To provide a better care for HIV-infected patients receiving antiretroviral therapy with hyperlipidemia, routine HIV/AIDS care with individualized nutritional counseling integration and adequate knowledge of dyslipidemia provision are recommended.

Subjects/Keywords: Epidemiology; Nutrition; antiretroviral therapy; HIV-infected person; LDL cholesterol; nutritional counseling; Thailand

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Chotivichien, S. (2013). Effect of nutritional counseling on low-density lipoprotein (LDL) cholesterol among Thai HIV-infected adults receiving antiretroviral therapy. (Thesis). UCLA. Retrieved from http://www.escholarship.org/uc/item/9w04j709

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Chotivichien, Saipin. “Effect of nutritional counseling on low-density lipoprotein (LDL) cholesterol among Thai HIV-infected adults receiving antiretroviral therapy.” 2013. Thesis, UCLA. Accessed January 23, 2021. http://www.escholarship.org/uc/item/9w04j709.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Chotivichien, Saipin. “Effect of nutritional counseling on low-density lipoprotein (LDL) cholesterol among Thai HIV-infected adults receiving antiretroviral therapy.” 2013. Web. 23 Jan 2021.

Vancouver:

Chotivichien S. Effect of nutritional counseling on low-density lipoprotein (LDL) cholesterol among Thai HIV-infected adults receiving antiretroviral therapy. [Internet] [Thesis]. UCLA; 2013. [cited 2021 Jan 23]. Available from: http://www.escholarship.org/uc/item/9w04j709.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Chotivichien S. Effect of nutritional counseling on low-density lipoprotein (LDL) cholesterol among Thai HIV-infected adults receiving antiretroviral therapy. [Thesis]. UCLA; 2013. Available from: http://www.escholarship.org/uc/item/9w04j709

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Connecticut

27. Cusack, Laura Kells. Cholesterol Lowering Effects of Milk with Added Phytosterols.

Degree: MS, Kinesiology, 2012, University of Connecticut

URL: https://opencommons.uconn.edu/gs_theses/270

► <h1> </h1> Foods incorporating plant sterols (PS) reduce Low-density lipoprotein (LDL) on average approximately 10%. PS with a higher lipid solubility may promote greater reductions.… (more)

Subjects/Keywords: cholesterol; phytosterol; plant sterol; plant stanol; apolipoprotein B; apolipoprotein A1; LDL; HDL

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APA (6^th Edition):

Cusack, L. K. (2012). Cholesterol Lowering Effects of Milk with Added Phytosterols. (Masters Thesis). University of Connecticut. Retrieved from https://opencommons.uconn.edu/gs_theses/270

Chicago Manual of Style (16^th Edition):

Cusack, Laura Kells. “Cholesterol Lowering Effects of Milk with Added Phytosterols.” 2012. Masters Thesis, University of Connecticut. Accessed January 23, 2021. https://opencommons.uconn.edu/gs_theses/270.

MLA Handbook (7^th Edition):

Cusack, Laura Kells. “Cholesterol Lowering Effects of Milk with Added Phytosterols.” 2012. Web. 23 Jan 2021.

Vancouver:

Cusack LK. Cholesterol Lowering Effects of Milk with Added Phytosterols. [Internet] [Masters thesis]. University of Connecticut; 2012. [cited 2021 Jan 23]. Available from: https://opencommons.uconn.edu/gs_theses/270.

Council of Science Editors:

Cusack LK. Cholesterol Lowering Effects of Milk with Added Phytosterols. [Masters Thesis]. University of Connecticut; 2012. Available from: https://opencommons.uconn.edu/gs_theses/270

University of Illinois – Chicago

28. Pradella, Fabio. A Novel Serum-Free Medium Formulation for Human Liver Cultures with Applications in Drug Screening.

Degree: 2018, University of Illinois – Chicago

URL: http://hdl.handle.net/10027/23124

► The liver is the largest internal organ of the human body and provides for a wide range of functions, which can be seriously compromised by… (more)

▼ The liver is the largest internal organ of the human body and provides for a wide range of functions, which can be seriously compromised by toxic drugs and diseases. In order to develop novel and safer drugs, in vitro models of the human liver are increasingly adopted to complement drug screenings in animal models, known to have species-specific differences in liver pathways. Micropatterned co-cultures (MPCCs) of primary human hepatocytes (PHHs) and supportive 3T3-J2 murine embryonic fibroblasts maintain high levels of liver functions for several weeks in vitro and have been highly useful to screen for drug toxicity and mimic key mechanisms of liver diseases, such as non-alcoholic fatty liver disease (NAFLD), a condition that affects ~30% of patients in the US and is highly correlated to obesity. When culturing cells, bovine serum is commonly used; however, it is problematic given its variability and the mismatch of proteins across species. Nonetheless, avoiding the use of bovine serum in the cell culture medium results in reduced proliferation and number of fibroblasts, in turn causing a rapid decline in PHH functions. Therefore, in this thesis we firstly developed a novel animal serum-free culture medium by implementing low levels of both low density lipoproteins (LDL) and high density lipoproteins (HDL), able to induce and maintain MPCC functions for several weeks towards significantly higher levels than the current serum-free medium formulation. Secondly, we tested the newly developed serum-free medium formulation for drug screening against MPCCs induced towards a NAFLD phenotype (steatosis and insulin resistance) using either a mixture of fatty acids found in the human diet or human serum, evaluating the efficacy of clinical drugs (2,4- dinitrophenol and pioglitazone) at non-toxic concentrations. Although unable to reduce hepatic steatosis, insulin sensitivity improved transiently, whereas steatotic PHHs spontaneously purged intracellular lipids irrespective of drug therapy upon removal of fatty acids from the culture, suggesting that diet restriction may be critical for alleviating NAFLD in patients. Ultimately, our model system together with the newly developed serum-free medium can prove useful for developing novel and safe drugs against liver diseases towards alleviating the disease burden on the human population. Advisors/Committee Members: Khetani, Salman R (advisor), Eddington, David T (committee member), Farè, Silvia (committee member), Khetani, Salman R (chair).

Subjects/Keywords: Liver; Hepatocyte; PHH; Serum-free; Cholesterol; HDL; LDL; NAFLD; Fatty acid; Drug; In vitro

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APA (6^th Edition):

Pradella, F. (2018). A Novel Serum-Free Medium Formulation for Human Liver Cultures with Applications in Drug Screening. (Thesis). University of Illinois – Chicago. Retrieved from http://hdl.handle.net/10027/23124

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Pradella, Fabio. “A Novel Serum-Free Medium Formulation for Human Liver Cultures with Applications in Drug Screening.” 2018. Thesis, University of Illinois – Chicago. Accessed January 23, 2021. http://hdl.handle.net/10027/23124.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Pradella, Fabio. “A Novel Serum-Free Medium Formulation for Human Liver Cultures with Applications in Drug Screening.” 2018. Web. 23 Jan 2021.

Vancouver:

Pradella F. A Novel Serum-Free Medium Formulation for Human Liver Cultures with Applications in Drug Screening. [Internet] [Thesis]. University of Illinois – Chicago; 2018. [cited 2021 Jan 23]. Available from: http://hdl.handle.net/10027/23124.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Pradella F. A Novel Serum-Free Medium Formulation for Human Liver Cultures with Applications in Drug Screening. [Thesis]. University of Illinois – Chicago; 2018. Available from: http://hdl.handle.net/10027/23124

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

29. Mazzaferro, Eugenia. Identification and characterization of causal genes for LDL cholesterol levels and downstream effects on atherosclerosis.

Degree: Bioscience, 2017, University of Skövde

URL: http://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-14650

► Coronary artery disease is the leading cause of death worldwide and results from progression of atherosclerosis, which is triggered in part by elevated plasma… (more)

Subjects/Keywords: CRISPR/Cas9; Zebrafish; Atherosclerosis; LDL cholesterol; Natural Sciences; Naturvetenskap; Medical Biotechnology; Medicinsk bioteknologi

10 more images…

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Mazzaferro, E. (2017). Identification and characterization of causal genes for LDL cholesterol levels and downstream effects on atherosclerosis. (Thesis). University of Skövde. Retrieved from http://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-14650

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Mazzaferro, Eugenia. “Identification and characterization of causal genes for LDL cholesterol levels and downstream effects on atherosclerosis.” 2017. Thesis, University of Skövde. Accessed January 23, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-14650.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Mazzaferro, Eugenia. “Identification and characterization of causal genes for LDL cholesterol levels and downstream effects on atherosclerosis.” 2017. Web. 23 Jan 2021.

Vancouver:

Mazzaferro E. Identification and characterization of causal genes for LDL cholesterol levels and downstream effects on atherosclerosis. [Internet] [Thesis]. University of Skövde; 2017. [cited 2021 Jan 23]. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-14650.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Mazzaferro E. Identification and characterization of causal genes for LDL cholesterol levels and downstream effects on atherosclerosis. [Thesis]. University of Skövde; 2017. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-14650

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Helsinki

30. Keränen, Emmi. Familiaalinen hyperkolesterolemia lapsilla : hoidon pariin hakeutuminen ja sen vaikutukset.

Degree: Medicinska fakulteten, 2015, University of Helsinki

URL: http://hdl.handle.net/10138/159894

► Familiaalinen hyperkolesterolemia on dominantisti periytyvä LDL-reseptorin sairaus, joka johtaa plasman kohonneeseen LDL-kolesterolipitoisuuteen ja aiheuttaa hoitamattomana varhaista ateroskleroosia ja sepelvaltimotautia. Tauti on lapsuudessa usein oireeton ja… (more)

Subjects/Keywords: Child; Cholesterol; Familial Hypercholesterolemia; LDL receptor; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Paediatrics; Lastentaudit; Barnsjukdomar

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Keränen, E. (2015). Familiaalinen hyperkolesterolemia lapsilla : hoidon pariin hakeutuminen ja sen vaikutukset. (Masters Thesis). University of Helsinki. Retrieved from http://hdl.handle.net/10138/159894

Chicago Manual of Style (16^th Edition):

Keränen, Emmi. “Familiaalinen hyperkolesterolemia lapsilla : hoidon pariin hakeutuminen ja sen vaikutukset.” 2015. Masters Thesis, University of Helsinki. Accessed January 23, 2021. http://hdl.handle.net/10138/159894.

MLA Handbook (7^th Edition):

Keränen, Emmi. “Familiaalinen hyperkolesterolemia lapsilla : hoidon pariin hakeutuminen ja sen vaikutukset.” 2015. Web. 23 Jan 2021.

Vancouver:

Keränen E. Familiaalinen hyperkolesterolemia lapsilla : hoidon pariin hakeutuminen ja sen vaikutukset. [Internet] [Masters thesis]. University of Helsinki; 2015. [cited 2021 Jan 23]. Available from: http://hdl.handle.net/10138/159894.

Council of Science Editors:

Keränen E. Familiaalinen hyperkolesterolemia lapsilla : hoidon pariin hakeutuminen ja sen vaikutukset. [Masters Thesis]. University of Helsinki; 2015. Available from: http://hdl.handle.net/10138/159894

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Open Access Theses and Dissertations