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University of Manchester

1. Sanaei Nezhad, Faezeh. Magnetic Resonance Spectroscopy as part of a comprehensive neuroimaging assessment tool.

Degree: 2018, University of Manchester

Magnetic resonance spectroscopy (MRS) allows the non-invasive measurement of selected biological compounds in vivo. Despite MRS proven potential it is not yet a routine clinical tool operated by clinicians. This is mainly due to the complex procedure of MRS acquisition, lack of standardisation in both acquisition and analysis protocols along with lack of a standard quality control. This thesis intended to address these issues with the focus on four metabolites glutathione, glutamate, glutamine and GABA using MEGA-PRESS pulse sequence. Recommendations on acquisition and spectra analysis is made for the MRS protocol MEGA-PRESS aiming to detect glutathione in vivo. This is based on an investigation of glutathione acquisition in vivo and in vitro and was aimed to answer the question: can glutathione be measured reliably using conventional pulse sequence PRESS or does it require editing? The results showed strong evidence of using editing in order to have a reliable glutathione concentration measurement. An analysis along with a quality control method is also presented to enable the extraction of glutamate and glutamine from a GABA-optimised MEGA-PRESS pulse sequence. This enables simultaneous measurements of GABA, glutamate and glutamine in a single acquisition. A criterion of NAA linewidth <8 Hz and Glx CRLB <16% were defined as optimum features in the GABA-edited spectrum for a reliable glutamate and glutamine quantification. Finally, due to the increasing interest in functional MRS of GABA using MEGA- PRESS an investigation on the feasibility of measuring GABA in a functional-MRS setting was performed with recommendations on study designs and subject size. Power calculations suggest that detecting a 40% change in GABA using a 4’30†acquisition requires 9-93 subjects per group in a between-group study design and 13- 68 participants in a within-session design, depending on the region of interest. This thesis is set out in the Journal format thesis. Three introductory chapters, with each experimental study presented as a chapter and a final chapter that summarises and discusses the work. Results in this thesis provide a basis for a standard and reliable MRS pipeline to reliably measure glutathione, glutamate, glutamine and GABA using MEGA-PRESS pulse sequence at 3 Tesla. Advisors/Committee Members: PARKES, LAURA LM, Williams, Stephen, Parkes, Laura.

Subjects/Keywords: spectroscopy; Glutathione; Glutamate; Glutamine; GABA; PRESS; MEGA-PRESS; J-editing

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Sanaei Nezhad, F. (2018). Magnetic Resonance Spectroscopy as part of a comprehensive neuroimaging assessment tool. (Doctoral Dissertation). University of Manchester. Retrieved from http://www.manchester.ac.uk/escholar/uk-ac-man-scw:313312

Chicago Manual of Style (16th Edition):

Sanaei Nezhad, Faezeh. “Magnetic Resonance Spectroscopy as part of a comprehensive neuroimaging assessment tool.” 2018. Doctoral Dissertation, University of Manchester. Accessed November 20, 2019. http://www.manchester.ac.uk/escholar/uk-ac-man-scw:313312.

MLA Handbook (7th Edition):

Sanaei Nezhad, Faezeh. “Magnetic Resonance Spectroscopy as part of a comprehensive neuroimaging assessment tool.” 2018. Web. 20 Nov 2019.

Vancouver:

Sanaei Nezhad F. Magnetic Resonance Spectroscopy as part of a comprehensive neuroimaging assessment tool. [Internet] [Doctoral dissertation]. University of Manchester; 2018. [cited 2019 Nov 20]. Available from: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:313312.

Council of Science Editors:

Sanaei Nezhad F. Magnetic Resonance Spectroscopy as part of a comprehensive neuroimaging assessment tool. [Doctoral Dissertation]. University of Manchester; 2018. Available from: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:313312


University of Manchester

2. Sanaei Nezhad, Faezeh. Magnetic resonance spectroscopy as part of a comprehensive neuroimaging assessment tool.

Degree: PhD, 2018, University of Manchester

Magnetic resonance spectroscopy (MRS) allows the non-invasive measurement of selected biological compounds in vivo. Despite MRS proven potential it is not yet a routine clinical tool operated by clinicians. This is mainly due to the complex procedure of MRS acquisition, lack of standardisation in both acquisition and analysis protocols along with lack of a standard quality control. This thesis intended to address these issues with the focus on four metabolites glutathione, glutamate, glutamine and GABA using MEGA-PRESS pulse sequence. Recommendations on acquisition and spectra analysis is made for the MRS protocol MEGA-PRESS aiming to detect glutathione in vivo. This is based on an investigation of glutathione acquisition in vivo and in vitro and was aimed to answer the question: can glutathione be measured reliably using conventional pulse sequence PRESS or does it require editing? The results showed strong evidence of using editing in order to have a reliable glutathione concentration measurement. An analysis along with a quality control method is also presented to enable the extraction of glutamate and glutamine from a GABA-optimised MEGA-PRESS pulse sequence. This enables simultaneous measurements of GABA, glutamate and glutamine in a single acquisition. A criterion of NAA linewidth < 8 Hz and Glx CRLB < 16% were defined as optimum features in the GABA-edited spectrum for a reliable glutamate and glutamine quantification. Finally, due to the increasing interest in functional MRS of GABA using MEGAPRESS an investigation on the feasibility of measuring GABA in a functional-MRS setting was performed with recommendations on study designs and subject size. Power calculations suggest that detecting a 40% change in GABA using a 4'30" acquisition requires 9-93 subjects per group in a between-group study design and 13- 68 participants in a within-session design, depending on the region of interest. This thesis is set out in the Journal format thesis. Three introductory chapters, with each experimental study presented as a chapter and a final chapter that summarizes and discusses the work. Results in this thesis provide a basis for a standard and reliable MRS pipeline to reliably measure glutathione, glutamate, glutamine and GABA using MEGA-PRESS pulse sequence at 3 Tesla.

Subjects/Keywords: J-editing; PRESS; GABA; MEGA-PRESS; Glutamate; Glutathione; spectroscopy; Glutamine

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Sanaei Nezhad, F. (2018). Magnetic resonance spectroscopy as part of a comprehensive neuroimaging assessment tool. (Doctoral Dissertation). University of Manchester. Retrieved from https://www.research.manchester.ac.uk/portal/en/theses/magnetic-resonance-spectroscopy-as-part-of-a-comprehensive-neuroimaging-assessment-tool(74f20119-ba2b-4919-a306-4585d43e2b6c).html ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.740337

Chicago Manual of Style (16th Edition):

Sanaei Nezhad, Faezeh. “Magnetic resonance spectroscopy as part of a comprehensive neuroimaging assessment tool.” 2018. Doctoral Dissertation, University of Manchester. Accessed November 20, 2019. https://www.research.manchester.ac.uk/portal/en/theses/magnetic-resonance-spectroscopy-as-part-of-a-comprehensive-neuroimaging-assessment-tool(74f20119-ba2b-4919-a306-4585d43e2b6c).html ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.740337.

MLA Handbook (7th Edition):

Sanaei Nezhad, Faezeh. “Magnetic resonance spectroscopy as part of a comprehensive neuroimaging assessment tool.” 2018. Web. 20 Nov 2019.

Vancouver:

Sanaei Nezhad F. Magnetic resonance spectroscopy as part of a comprehensive neuroimaging assessment tool. [Internet] [Doctoral dissertation]. University of Manchester; 2018. [cited 2019 Nov 20]. Available from: https://www.research.manchester.ac.uk/portal/en/theses/magnetic-resonance-spectroscopy-as-part-of-a-comprehensive-neuroimaging-assessment-tool(74f20119-ba2b-4919-a306-4585d43e2b6c).html ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.740337.

Council of Science Editors:

Sanaei Nezhad F. Magnetic resonance spectroscopy as part of a comprehensive neuroimaging assessment tool. [Doctoral Dissertation]. University of Manchester; 2018. Available from: https://www.research.manchester.ac.uk/portal/en/theses/magnetic-resonance-spectroscopy-as-part-of-a-comprehensive-neuroimaging-assessment-tool(74f20119-ba2b-4919-a306-4585d43e2b6c).html ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.740337


Louisiana State University

3. Healy, Christopher Andrew. The "minor" author and the major editor: a case study in determining the canon.

Degree: PhD, English Language and Literature, 2002, Louisiana State University

This dissertation explores the relationship between a literary work and its printed edition in the production of reputation – the editor as gatekeeper of the reputation of a “minor” poet. That relationship is demonstrated through a case study on the effects of the nineteenth-century edition of the works of the fifteenth-century poet Thomas Hoccleve and an analysis of the lingering effects of the Foucauldian “editor-function.” The number of surviving manuscripts indicates that Hoccleve’s work was well-regarded during the early fifteenth century, but his reputation fell with that of other non-Chaucerian medieval poets as later critics lost linguistic familiarity with Middle English. The Victorian-era work of the Early English Text Society was intended to reclaim the positive reception for medieval works; however, the EETS offerings achieved just the opposite result for Hoccleve’s poetry and perpetuated the negative reputation the poet had acquired. Frederick J. Furnivall’s EETS “standard” Hoccleve editions, still in print, are largely unfavorable in the crucial prefatory matter, even though it is rife with transparent Victorian prejudices. Furnivall’s text itself is haphazardly irregular, frequently producing – not reproducing – the same flaws the forewords criticize. As these blemished editions have remained the standard for over a century, Furnivall’s editorial irresponsibility undoubtedly slowed the critical re-evaluation of Hoccleve, which began at the end of the twentieth century.

Subjects/Keywords: frederick j. furnivall; middle english; thomas hoccleve; early english text society (eets); canon construction; textual editing

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Healy, C. A. (2002). The "minor" author and the major editor: a case study in determining the canon. (Doctoral Dissertation). Louisiana State University. Retrieved from etd-1008102-162013 ; https://digitalcommons.lsu.edu/gradschool_dissertations/3004

Chicago Manual of Style (16th Edition):

Healy, Christopher Andrew. “The "minor" author and the major editor: a case study in determining the canon.” 2002. Doctoral Dissertation, Louisiana State University. Accessed November 20, 2019. etd-1008102-162013 ; https://digitalcommons.lsu.edu/gradschool_dissertations/3004.

MLA Handbook (7th Edition):

Healy, Christopher Andrew. “The "minor" author and the major editor: a case study in determining the canon.” 2002. Web. 20 Nov 2019.

Vancouver:

Healy CA. The "minor" author and the major editor: a case study in determining the canon. [Internet] [Doctoral dissertation]. Louisiana State University; 2002. [cited 2019 Nov 20]. Available from: etd-1008102-162013 ; https://digitalcommons.lsu.edu/gradschool_dissertations/3004.

Council of Science Editors:

Healy CA. The "minor" author and the major editor: a case study in determining the canon. [Doctoral Dissertation]. Louisiana State University; 2002. Available from: etd-1008102-162013 ; https://digitalcommons.lsu.edu/gradschool_dissertations/3004

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