subject:(Ischemic stroke)

1. Buesch, Barbara. Early Mobilization of Stroke Patients .

Degree: 2012, California State University – San Marcos

► Statement of Problem: The purpose of the evidence based practice project was to examine the feasibility of ceveloping an early mobilization program for an acute… (more)

Subjects/Keywords: stroke; rehabilitation; ischemic stroke

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APA (6^th Edition):

Buesch, B. (2012). Early Mobilization of Stroke Patients . (Thesis). California State University – San Marcos. Retrieved from http://hdl.handle.net/10211.8/145

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Buesch, Barbara. “Early Mobilization of Stroke Patients .” 2012. Thesis, California State University – San Marcos. Accessed January 19, 2021. http://hdl.handle.net/10211.8/145.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Buesch, Barbara. “Early Mobilization of Stroke Patients .” 2012. Web. 19 Jan 2021.

Vancouver:

Buesch B. Early Mobilization of Stroke Patients . [Internet] [Thesis]. California State University – San Marcos; 2012. [cited 2021 Jan 19]. Available from: http://hdl.handle.net/10211.8/145.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Buesch B. Early Mobilization of Stroke Patients . [Thesis]. California State University – San Marcos; 2012. Available from: http://hdl.handle.net/10211.8/145

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

2. Gonzalez Rivero, Hermelinda. Improving the Care for Acute Ischemic Stroke Patients.

Degree: MSN, 2018, University of San Francisco

URL: https://repository.usfca.edu/capstone/800

► Abstract Problem: Decreasing the time to assess acute ischemic stroke patients impacts the patients’ well-being. The clinical benefit of intravenous Alteplase for ischemic stroke… (more)

▼ Abstract Problem: Decreasing the time to assess acute ischemic stroke patients impacts the patients’ well-being. The clinical benefit of intravenous Alteplase for ischemic stroke patients results in better outcomes. Intravenous thrombolysis success is dependent on narrowing time to treat (Fonarow et al., 2014). Decreasing the time to intravenous thrombolysis for acute ischemic stroke patients augments the ability of patients to improve the quality of life by minimizing disability and improving health outcomes (Speirs & Mitchell, 2015). Context: The microsystem chosen for this evidence-based change of practice project change takes place in the Northern California emergency department (ED). The ED provides care for patients in life-threatening situations, acute, and chronic conditions. The ED also serves as a health care safety net for the Northern California community. The ED is a high functioning, stressful environment, that when there is an increase of patients and not enough resources this impacts on the Altepase administration timing. Interventions: The description of changes to test includes daily stroke team assignments, stroke kits, education through electronic modules, and stroke code simulation. At the start of every shift the assistant nurse manager (ANM) will choose the stroke team for each shift. Implementing stroke kits and placing them on top of the Telestroke Cisco Cart (video telemedicine platform) will help support the DTN time. Stroke kits will include a hard copy of a stroke check off list and intravenous (IV) start kit and IV tubing. We will also share current goals of AIS patients receiving Alteplase, which may include having staff watch modules. The team will initiate monthly simulation Stroke Codes. Test workflows during simulation Stroke Codes will be implemented at least three times day on various shifts. Measures: One of the ED-specific metrics that matter is the Stroke Alteplase door-to-needle (DTN) time, which should be less than or equal to 30 minutes. The quality gap in ED is not having enough resources for increase census and not meeting the monthly metrics measures baseline of 50%. Given that the number of patients arriving to the ED can impact the duration of time of Alteplase administration, the typical time is longer than 30 minutes. Results: Significantly, there is an improvement from January 2017 to April 2018. The DTN Alteplase administration to less and equal to 30 minutes increased from 43% prior to intervention to 55% after the intervention were implemented. Since the intervention, there was an increase on the ED DTN response time. However, there is not enough data that points to say that there is a trend in the process. The percentage of staff members completing modules in Health Connect (HC) is 90%. (Quality and Operations Support: The Permanente… Advisors/Committee Members: Nancy Taquino.

Subjects/Keywords: Ischemic Stroke; Critical Care Nursing

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APA (6^th Edition):

Gonzalez Rivero, H. (2018). Improving the Care for Acute Ischemic Stroke Patients. (Thesis). University of San Francisco. Retrieved from https://repository.usfca.edu/capstone/800

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Gonzalez Rivero, Hermelinda. “Improving the Care for Acute Ischemic Stroke Patients.” 2018. Thesis, University of San Francisco. Accessed January 19, 2021. https://repository.usfca.edu/capstone/800.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Gonzalez Rivero, Hermelinda. “Improving the Care for Acute Ischemic Stroke Patients.” 2018. Web. 19 Jan 2021.

Vancouver:

Gonzalez Rivero H. Improving the Care for Acute Ischemic Stroke Patients. [Internet] [Thesis]. University of San Francisco; 2018. [cited 2021 Jan 19]. Available from: https://repository.usfca.edu/capstone/800.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Gonzalez Rivero H. Improving the Care for Acute Ischemic Stroke Patients. [Thesis]. University of San Francisco; 2018. Available from: https://repository.usfca.edu/capstone/800

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

California State University – Sacramento

3. Meza, Manuel. Outpatient rehabilitation for a patient following a right hemispheric ischemic stroke.

Degree: 2016, California State University – Sacramento

URL: http://hdl.handle.net/10211.3/172693

► A patient with an ischemic stroke occluding the right middle cerebral artery was seen for physical therapy treatment for 12 sessions from 4/7/15 to 5/15/15… (more)

Subjects/Keywords: Right hemispheric stroke rehabilitation; Ischemic stroke rehabilitation; Outpatient stroke rehabilitation

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APA (6^th Edition):

Meza, M. (2016). Outpatient rehabilitation for a patient following a right hemispheric ischemic stroke. (Thesis). California State University – Sacramento. Retrieved from http://hdl.handle.net/10211.3/172693

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Meza, Manuel. “Outpatient rehabilitation for a patient following a right hemispheric ischemic stroke.” 2016. Thesis, California State University – Sacramento. Accessed January 19, 2021. http://hdl.handle.net/10211.3/172693.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Meza, Manuel. “Outpatient rehabilitation for a patient following a right hemispheric ischemic stroke.” 2016. Web. 19 Jan 2021.

Vancouver:

Meza M. Outpatient rehabilitation for a patient following a right hemispheric ischemic stroke. [Internet] [Thesis]. California State University – Sacramento; 2016. [cited 2021 Jan 19]. Available from: http://hdl.handle.net/10211.3/172693.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Meza M. Outpatient rehabilitation for a patient following a right hemispheric ischemic stroke. [Thesis]. California State University – Sacramento; 2016. Available from: http://hdl.handle.net/10211.3/172693

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of California – Irvine

4. Hancock, Aneeka. A sensory stimulation-based collateral therapeutic for ischemic stroke: new insights and limitations.

Degree: Biological Sciences, 2015, University of California – Irvine

URL: http://www.escholarship.org/uc/item/33d179zc

► Stroke is currently the leading cause of long-term disability and the fifth leading cause of death in the United States, and prevalence is on the… (more)

Subjects/Keywords: Neurosciences; Biology; Ischemic Stroke; Neuroprotection; Neurovascular Plasticity

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APA (6^th Edition):

Hancock, A. (2015). A sensory stimulation-based collateral therapeutic for ischemic stroke: new insights and limitations. (Thesis). University of California – Irvine. Retrieved from http://www.escholarship.org/uc/item/33d179zc

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Hancock, Aneeka. “A sensory stimulation-based collateral therapeutic for ischemic stroke: new insights and limitations.” 2015. Thesis, University of California – Irvine. Accessed January 19, 2021. http://www.escholarship.org/uc/item/33d179zc.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Hancock, Aneeka. “A sensory stimulation-based collateral therapeutic for ischemic stroke: new insights and limitations.” 2015. Web. 19 Jan 2021.

Vancouver:

Hancock A. A sensory stimulation-based collateral therapeutic for ischemic stroke: new insights and limitations. [Internet] [Thesis]. University of California – Irvine; 2015. [cited 2021 Jan 19]. Available from: http://www.escholarship.org/uc/item/33d179zc.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Hancock A. A sensory stimulation-based collateral therapeutic for ischemic stroke: new insights and limitations. [Thesis]. University of California – Irvine; 2015. Available from: http://www.escholarship.org/uc/item/33d179zc

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Rochester

5. Xian, Ying. Do Healthcare Process and Outcomes Differ for Acute Ischemic Stroke Patients Admitted to Designated Stroke Centers?.

Degree: PhD, 2011, University of Rochester

URL: http://hdl.handle.net/1802/13980

► Stroke is the third leading cause of mortality and the leading cause of serious long-term disability in the Unites States. Establishment of designated stroke centers… (more)

▼ Stroke is the third leading cause of mortality and the leading cause of serious long-term disability in the Unites States. Establishment of designated stroke centers has great potential to improve acute stroke care. Despite widespread support for the stroke center concept, few studies have demonstrated improved process of care at designated stroke centers, and none has examined mortality outcomes. This dissertation uses New York Statewide Planning and Research Cooperative System data (2005-2006) to examine two research questions controlling for the non-randomized study design: (1) Do New York State designated stroke centers increase the use of thrombolytic therapy among patients with acute ischemic stroke? (2) Do designated stroke centers reduce mortality? In addition, we evaluate racial/ethnic differences in the use of thrombolytic therapy and mortality. Our studies resulted in the following observations: • Compared to patients at non-designated hospitals, patients who were treated at designated stroke centers were significantly more likely to receive thrombolytic therapy. • Receiving care at designated stroke centers was associated with significantly lower mortality, almost one percent (0.93%) lower within the hospital and 2.59%, 2.65%, 1.76%, and 2.29% lower at 30, 90, and 180 days and one year after stroke admission, respectively. • Non-Hispanic blacks were less likely than non-Hispanic whites to be treated at designated stroke centers. • Non-Hispanic blacks were less likely to receive thrombolytic therapy. • Non-Hispanic blacks had lower in-hospital mortality and lower short- and intermediate-term mortality than non-Hispanic whites. However, the survival advantage among blacks was diminishing as time after discharge increased. • Lower mortality among non-Hispanic blacks may be due to lower use of palliative care such as hospice and greater use of life-sustaining interventions including hemodialysis, gastrostomy, and enteral/parenteral nutrition. In conclusion, this dissertation validates two expected benefits of designated stroke centers, namely, increased use of thrombolytic therapy and reduced mortality. Racial disparities remain in access to quality stroke care and use of evidence-based treatment. Expanding designated stroke centers nationwide has the potential for improving quality of stroke care, reducing stroke-related health disparities, and enhancing patient outcomes.

Subjects/Keywords: Quality Improvement; Outcomes Research; Acute Ischemic Stroke

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APA (6^th Edition):

Xian, Y. (2011). Do Healthcare Process and Outcomes Differ for Acute Ischemic Stroke Patients Admitted to Designated Stroke Centers?. (Doctoral Dissertation). University of Rochester. Retrieved from http://hdl.handle.net/1802/13980

Chicago Manual of Style (16^th Edition):

Xian, Ying. “Do Healthcare Process and Outcomes Differ for Acute Ischemic Stroke Patients Admitted to Designated Stroke Centers?.” 2011. Doctoral Dissertation, University of Rochester. Accessed January 19, 2021. http://hdl.handle.net/1802/13980.

MLA Handbook (7^th Edition):

Xian, Ying. “Do Healthcare Process and Outcomes Differ for Acute Ischemic Stroke Patients Admitted to Designated Stroke Centers?.” 2011. Web. 19 Jan 2021.

Vancouver:

Xian Y. Do Healthcare Process and Outcomes Differ for Acute Ischemic Stroke Patients Admitted to Designated Stroke Centers?. [Internet] [Doctoral dissertation]. University of Rochester; 2011. [cited 2021 Jan 19]. Available from: http://hdl.handle.net/1802/13980.

Council of Science Editors:

Xian Y. Do Healthcare Process and Outcomes Differ for Acute Ischemic Stroke Patients Admitted to Designated Stroke Centers?. [Doctoral Dissertation]. University of Rochester; 2011. Available from: http://hdl.handle.net/1802/13980

University of Rochester

6. Feola, Julianne. The Role of Astrocytic Transglutaminase 2 in Mediating Cellular.

Degree: PhD, 2017, University of Rochester

URL: http://hdl.handle.net/1802/32540

► The powerful influences that astrocytes exert on neuronal function are undisputable, as astrocytes provide support to neurons under both basal and stressed conditions. Astrocytes are… (more)

▼ The powerful influences that astrocytes exert on neuronal function are undisputable, as astrocytes provide support to neurons under both basal and stressed conditions. Astrocytes are also vulnerable, however, to cellular stress, and disruptions in their normal functions can impede neuronal survival. The identification of astrocytic factors that play a significant role in mediating both astrocytic and neuronal viability is therefore imperative in further elucidating cellular disease processes. Transglutaminase 2 (TG2) is a protein with widespread functionality and ubiquitous cellular expression. TG2 has been considered to be both pro-cell death and pro-survival in various cellular contexts and disease states. Our lab has demonstrated that the expression of TG2 in neurons is beneficial to their survival following an ischemic injury, but that TG2 expression in astrocytes is detrimental to astrocytic survival. Furthermore, astrocytic TG2 expression negatively impacts neuronal survival in ischemic conditions. The aim of this body of work was to expand upon this finding and further elucidate the characteristics and functions of TG2 within astrocytes that contribute to both astrocytic and neuronal cellular damage in ischemic conditions. Previous work has shown that the subcellular localization of TG2 can impact its ability to modulate cellular viability. Therefore, in Chapter 2, we explored the subcellular localization patterns of TG2 in astrocytes. TG2 levels were reduced in the nucleus of hypoxic astrocytes as compared to normoxic astrocytes, which is in direct contrast to what has been shown in neurons. In addition, targeting TG2 specifically to the nucleus prevented TG2 from exerting its detrimental effects on astrocytic survival in response to oxygen/glucose deprivation (OGD). We further explored the mechanisms by which TG2 may be contributing to astrocytic cell death in Chapter 3 by examining its activity state and its ability to modulate intracellular signaling. Results demonstrated that both lentiviralmediated knockdown of TG2 and inhibition of its transamidation activity protected astrocytes from OGD. In addition, TG2 depletion increased basal and hypoxic NF-κB transcriptional activity in astrocytes. The ability of TG2 to modulate NF-κB signaling is separate from its ability to mediate cellular viability, as genetic manipulation of NF-κB activity had no effect on astrocytic viability. Studies were also conducted to investigate the mechanism(s) by which astrocytic TG2 depletion is beneficial to neuronal survival in OGD. In Chapter 4, we showed, with the use of a transwell assay, that the greater protection conferred to neurons by TG2 depleted astrocytes can occur in the absence of direct cellular contact. To begin to understand why, we chose to investigate differences in various metabolic processes between WT and TG2-/- cells. While we did see an increase in glucose uptake in TG2-/- astrocytes exposed to an ischemic injury paradigm, we did not see any differences in the release of…

Subjects/Keywords: Astrocytes; Transglutaminase 2; Ischemic stroke; Cellular viability

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APA (6^th Edition):

Feola, J. (2017). The Role of Astrocytic Transglutaminase 2 in Mediating Cellular. (Doctoral Dissertation). University of Rochester. Retrieved from http://hdl.handle.net/1802/32540

Chicago Manual of Style (16^th Edition):

Feola, Julianne. “The Role of Astrocytic Transglutaminase 2 in Mediating Cellular.” 2017. Doctoral Dissertation, University of Rochester. Accessed January 19, 2021. http://hdl.handle.net/1802/32540.

MLA Handbook (7^th Edition):

Feola, Julianne. “The Role of Astrocytic Transglutaminase 2 in Mediating Cellular.” 2017. Web. 19 Jan 2021.

Vancouver:

Feola J. The Role of Astrocytic Transglutaminase 2 in Mediating Cellular. [Internet] [Doctoral dissertation]. University of Rochester; 2017. [cited 2021 Jan 19]. Available from: http://hdl.handle.net/1802/32540.

Council of Science Editors:

Feola J. The Role of Astrocytic Transglutaminase 2 in Mediating Cellular. [Doctoral Dissertation]. University of Rochester; 2017. Available from: http://hdl.handle.net/1802/32540

University of Alberta

7. Sivakumar, Leka. Cognitive Impairment following Transient Ischemic Attack and Minor Stroke.

Degree: MS, Centre for Neuroscience, 2013, University of Alberta

URL: https://era.library.ualberta.ca/files/rr171x30t

► Background: Ischemic stroke is associated with cognitive impairment, but the acute cognitive sequelae of transient ischemic attack (TIA) and minor stroke is unknown. We hypothesized… (more)

Subjects/Keywords: cognitive impairment; minor stroke; transient ischemic attack

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APA (6^th Edition):

Sivakumar, L. (2013). Cognitive Impairment following Transient Ischemic Attack and Minor Stroke. (Masters Thesis). University of Alberta. Retrieved from https://era.library.ualberta.ca/files/rr171x30t

Chicago Manual of Style (16^th Edition):

Sivakumar, Leka. “Cognitive Impairment following Transient Ischemic Attack and Minor Stroke.” 2013. Masters Thesis, University of Alberta. Accessed January 19, 2021. https://era.library.ualberta.ca/files/rr171x30t.

MLA Handbook (7^th Edition):

Sivakumar, Leka. “Cognitive Impairment following Transient Ischemic Attack and Minor Stroke.” 2013. Web. 19 Jan 2021.

Vancouver:

Sivakumar L. Cognitive Impairment following Transient Ischemic Attack and Minor Stroke. [Internet] [Masters thesis]. University of Alberta; 2013. [cited 2021 Jan 19]. Available from: https://era.library.ualberta.ca/files/rr171x30t.

Council of Science Editors:

Sivakumar L. Cognitive Impairment following Transient Ischemic Attack and Minor Stroke. [Masters Thesis]. University of Alberta; 2013. Available from: https://era.library.ualberta.ca/files/rr171x30t

University of Alberta

8. Tsang, Adrian. Sodium MRI of the Human Brain: Application to Ischemic Stroke and the Development of Multiple Quantum Filtering.

Degree: PhD, Department of Biomedical Engineering, 2013, University of Alberta

URL: https://era.library.ualberta.ca/files/ft848q979

► MRI of sodium in the brain is much more challenging compared to hydrogen. However, imaging of brain tissue sodium has been suggested to provide temporal… (more)

▼ MRI of sodium in the brain is much more challenging compared to hydrogen. However, imaging of brain tissue sodium has been suggested to provide temporal information in acute ischemic stroke that may benefit patients with unknown onset time such as those awake with symptoms. Furthermore, selective imaging of intracellular sodium may provide compartment specific changes early after onset prior to the increase of tissue sodium as demonstrated previously in animal models. Both inversion recovery (IR) and triple-quantum-filtering (TQF) methods have been proposed to probe sodium signal weighted toward intracellular. Unfortunately, signal is greatly reduced (more so for TQF) using compartment specific sodium imaging sequences. Consequently, intracellular-weighted sodium images, especially for TQF, are poor in spatial resolution with low signal-to-noise ratio (SNR). TQF signal is only ~10% of tissue sodium, or single quantum (SQ), signal in brain. In this thesis, SNR optimization for TQF sodium brain imaging is presented. The strategy of using longer RF pulses with smaller first flip angle and shorter repetition time is shown to improve SNR relative to the ‘standard’ implementation. In addition, inhomogeneous B0 field causes TQF signal loss. Results are shown to demonstrate that TQF signal loss due to off-resonance in most of the cerebrum is well within 10% and thus implementation of correction methods that incur significant scan time increase is not necessary. One aspect of potential sodium signal loss, which has mostly been ignored, is caused by sodium interactions in anisotropic ordered environments. Anisotropic sodium signal can be detected using the double-quantum magic angle (DQ-MA) sequence, which is similar to TQF with different flip angle and RF pulse phase cycling. Preliminary results show DQ-MA signals to appear throughout the brain and future studies are required to investigate the distribution of this signal. Sodium MRI performed in acute stroke patients in this thesis demonstrated that SQ sodium signal was unchanged in the ‘at-risk’ tissue but increased in the lesion core. However, the increase was not correlated with perfusion deficits. Additionally, IR sodium signal showed greater increase than SQ signal within the first fourteen hours after onset suggesting IR signal to reflect intracellular compartment changes.

Subjects/Keywords: Multiple Quantum Filtering; Ischemic Stroke; Sodium MRI

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APA (6^th Edition):

Tsang, A. (2013). Sodium MRI of the Human Brain: Application to Ischemic Stroke and the Development of Multiple Quantum Filtering. (Doctoral Dissertation). University of Alberta. Retrieved from https://era.library.ualberta.ca/files/ft848q979

Chicago Manual of Style (16^th Edition):

Tsang, Adrian. “Sodium MRI of the Human Brain: Application to Ischemic Stroke and the Development of Multiple Quantum Filtering.” 2013. Doctoral Dissertation, University of Alberta. Accessed January 19, 2021. https://era.library.ualberta.ca/files/ft848q979.

MLA Handbook (7^th Edition):

Tsang, Adrian. “Sodium MRI of the Human Brain: Application to Ischemic Stroke and the Development of Multiple Quantum Filtering.” 2013. Web. 19 Jan 2021.

Vancouver:

Tsang A. Sodium MRI of the Human Brain: Application to Ischemic Stroke and the Development of Multiple Quantum Filtering. [Internet] [Doctoral dissertation]. University of Alberta; 2013. [cited 2021 Jan 19]. Available from: https://era.library.ualberta.ca/files/ft848q979.

Council of Science Editors:

Tsang A. Sodium MRI of the Human Brain: Application to Ischemic Stroke and the Development of Multiple Quantum Filtering. [Doctoral Dissertation]. University of Alberta; 2013. Available from: https://era.library.ualberta.ca/files/ft848q979

University of Newcastle

9. Lin, Longting. Whole-brain CTP in acute ischemic stroke.

Degree: PhD, 2015, University of Newcastle

URL: http://hdl.handle.net/1959.13/1310399

►

Research Doctorate - Doctor of Philosophy (PhD)

Perfusion imaging technology not only enables stroke diagnosis by identifying the ischemic lesion earlier, but also helps the… (more)

▼

Research Doctorate - Doctor of Philosophy (PhD)

Perfusion imaging technology not only enables stroke diagnosis by identifying the ischemic lesion earlier, but also helps the clinician to make treatment decisions by further classifying the ischemic lesion into salvageable tissue and non-salvageable tissue. The imaging of salvageable tissue, penumbra, provides a direct target for reperfusion treatment. However, the accuracy of penumbra measurement with perfusion imaging has been questioned, especially with CT perfusion (CTP). Perfusion images, acquired on earlier generation instruments such as the16 or 64-detector scanners, have limited coverage of potentially ischemic brain, a factor recognised to reduce the accuracy of penumbra measurement. This limitation can be overcome by the advance in technology. The new generation “mega-detector” scanners, such as 320-detector Toshiba Aquilion One, provide whole brain coverage of 160mm from skull base to vertex. In this thesis, I presented a series of studies aiming to evaluate the utility of whole-brain CTP in acute ischemic stroke. The first study was to derive the optimal penumbra measurement on whole-brain CTP with the reference of ischemic tissue outcome, and the second study was to test the penumbra measurement of whole-brain CTP in predicting clinical patient outcome. The two studies found that only with the threshold setting at Tmax>6s or DT>3s, did the whole-brain CTP achieve high accuracy (>99%) in delineating acute ischemic penumbra and good sensitivity (>80%) in predicting favourable clinical outcome. It was also confirmed that the accuracy of penumbra measurement was comprised when the brain coverage of CTP decreased from 160mm to 20mm. Following two studies examined the utility of whole-brain CTP in the clinical setting. Firstly, CTP was compared to MRP, the perfusion modality that has already been well used in clinic. This work demonstrated that with whole brain coverage, CTP was as effective as MPR in measuring the acute penumbra and in selecting patients for reperfusion treatment. Secondly, a case by case review was carried out to assist clinicians in the interpretation CTP output. In conclusion, findings of this thesis support the usage of whole-brain CTP in acute ischemic stroke. Noticeably, the conclusion only applies to patients with anterior circulation stroke. Whole-brain CTP might also have advantage in detecting ischemic lesions in posterior circulation territory, which require studies to prove it in the future.

Advisors/Committee Members: University of Newcastle. Faculty of Health & Medicine, School of Medicine and Public Health.

Subjects/Keywords: CT perfusion; ischemic stroke; penumbra; reperfusion

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APA (6^th Edition):

Lin, L. (2015). Whole-brain CTP in acute ischemic stroke. (Doctoral Dissertation). University of Newcastle. Retrieved from http://hdl.handle.net/1959.13/1310399

Chicago Manual of Style (16^th Edition):

Lin, Longting. “Whole-brain CTP in acute ischemic stroke.” 2015. Doctoral Dissertation, University of Newcastle. Accessed January 19, 2021. http://hdl.handle.net/1959.13/1310399.

MLA Handbook (7^th Edition):

Lin, Longting. “Whole-brain CTP in acute ischemic stroke.” 2015. Web. 19 Jan 2021.

Vancouver:

Lin L. Whole-brain CTP in acute ischemic stroke. [Internet] [Doctoral dissertation]. University of Newcastle; 2015. [cited 2021 Jan 19]. Available from: http://hdl.handle.net/1959.13/1310399.

Council of Science Editors:

Lin L. Whole-brain CTP in acute ischemic stroke. [Doctoral Dissertation]. University of Newcastle; 2015. Available from: http://hdl.handle.net/1959.13/1310399

University of Newcastle

10. Bivard, Andrew. Perfusion imaging in acute and evolving brain ischemia.

Degree: PhD, 2013, University of Newcastle

URL: http://hdl.handle.net/1959.13/1036157

►

Research Doctorate - Doctor of Philosophy (PhD)

Background: Established acute stroke treatment protocols require further investigation to identify patients who are most likely to respond… (more)

▼

Research Doctorate - Doctor of Philosophy (PhD)

Background: Established acute stroke treatment protocols require further investigation to identify patients who are most likely to respond to treatment. The aim of hyper-acute ischemic stroke treatment is to salvage hypoperfused tissue that would infarct soon (penumbra), thus preserving brain tissue and allowing better functional recovery of an individual patient. Penumbral salvage is achieved by removal of a cerebrovascular occlusion in the cerebral circulatory system through the use of intravenous thrombolytic therapy (iv rtPA), or mechanical intra-arterial thrombus retrieval. However, the current clinical guidelines for the treatment of ischemic stroke totally fail to measure the volume of the treatable penumbra. This thesis aims to provide the technical ability to measure the acute penumbra and infarct core, using readily available clinical imaging techniques. Furthermore, this thesis also aims to provide the clinical relevance of measures of the acute infarct core and penumbra, when compared to current treatment guidelines. Objectives: This thesis investigated clinically accessible perfusion imaging techniques, such as Computed Tomography Perfusion, as well as Magnetic resonance perfusion weighted imaging and arterial spin labelling, for their utility in acute ischemic stroke. The specific aims of this thesis were: 1) Determine a method by which to investigate perfusion imaging as compared to current gold standard measurements of tissue pathophysiology. 2) Investigate the threshold cut offs to determine the acute critical tissue pathophysiology measurements of the acute penumbra and infarct core. 3) Optimise the measures of the acute penumbra and infarct core. 4) Standardise the measure of the acute penumbra and infarct core, or failing standardisation, determine the optimal thresholds for the acute infarct core and penumbra for all software post processing algorithms available. 5) Determine the clinical importance of measures of the acute penumbra and infarct core. 6) Finally, compare various perfusion techniques to one another to determine cross compatibility of different measures. Methods: A cohort of 320 acute ischemic stroke patients who were admitted to the John Hunter hospital were enrolled in the studies for this PhD. These patients underwent an acute CTP with a 24 hour follow-up MR sequence. Sixty seven patients also underwent an additional acute MR, with perfusion and diffusion imaging. Clinical assessments were performed on all patients acutely, at 24 hours and at 90 days post stroke by a certified neurologist or neurology registrar. Clinical assessments included the National Institutes of Health Stroke Scale (NIHSS), and a modified Rankin Score. All perfusion images underwent post processing using MiStar, a commercially available software package. MiStar generates the perfusion maps of cerebral blood flow (CBF), cerebral blood volume (CBV), mean transit time (MTT) and time to peak. Once imaging was processed and ready for analysis, a broad range of…

Advisors/Committee Members: University of Newcastle. Faculty of Health, School of Medicine and Public Health.

Subjects/Keywords: Ischemic stroke; MRI; CT; thesis by publication

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APA (6^th Edition):

Bivard, A. (2013). Perfusion imaging in acute and evolving brain ischemia. (Doctoral Dissertation). University of Newcastle. Retrieved from http://hdl.handle.net/1959.13/1036157

Chicago Manual of Style (16^th Edition):

Bivard, Andrew. “Perfusion imaging in acute and evolving brain ischemia.” 2013. Doctoral Dissertation, University of Newcastle. Accessed January 19, 2021. http://hdl.handle.net/1959.13/1036157.

MLA Handbook (7^th Edition):

Bivard, Andrew. “Perfusion imaging in acute and evolving brain ischemia.” 2013. Web. 19 Jan 2021.

Vancouver:

Bivard A. Perfusion imaging in acute and evolving brain ischemia. [Internet] [Doctoral dissertation]. University of Newcastle; 2013. [cited 2021 Jan 19]. Available from: http://hdl.handle.net/1959.13/1036157.

Council of Science Editors:

Bivard A. Perfusion imaging in acute and evolving brain ischemia. [Doctoral Dissertation]. University of Newcastle; 2013. Available from: http://hdl.handle.net/1959.13/1036157

University of Toronto

11. Purcell, Mary Irene. The Design and Synthesis of Neuroprotectants Based on an Endogenous Platform.

Degree: 2015, University of Toronto

URL: http://hdl.handle.net/1807/70515

►

There is a pressing need for the development of a neuroprotective therapy that limits neuronal injury in ischemic stroke patients. A diversity of neurotoxic factors,… (more)

Subjects/Keywords: Biology; Ischemic; Medicinal Chemistry; Stroke; Zinc; 0572

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Purcell, M. I. (2015). The Design and Synthesis of Neuroprotectants Based on an Endogenous Platform. (Masters Thesis). University of Toronto. Retrieved from http://hdl.handle.net/1807/70515

Chicago Manual of Style (16^th Edition):

Purcell, Mary Irene. “The Design and Synthesis of Neuroprotectants Based on an Endogenous Platform.” 2015. Masters Thesis, University of Toronto. Accessed January 19, 2021. http://hdl.handle.net/1807/70515.

MLA Handbook (7^th Edition):

Purcell, Mary Irene. “The Design and Synthesis of Neuroprotectants Based on an Endogenous Platform.” 2015. Web. 19 Jan 2021.

Vancouver:

Purcell MI. The Design and Synthesis of Neuroprotectants Based on an Endogenous Platform. [Internet] [Masters thesis]. University of Toronto; 2015. [cited 2021 Jan 19]. Available from: http://hdl.handle.net/1807/70515.

Council of Science Editors:

Purcell MI. The Design and Synthesis of Neuroprotectants Based on an Endogenous Platform. [Masters Thesis]. University of Toronto; 2015. Available from: http://hdl.handle.net/1807/70515

12. Cognat, Emmanuel. Lésions de la substance blanche dans la maladie CADASIL : White matter lesions in CADASIL.

Degree: Docteur es, Neurobiologie, 2016, Sorbonne Paris Cité

URL: http://www.theses.fr/2016USPCC139

► CADASIL est une forme héréditaire, autosomique dominante, de maladie des petits vaisseaux cérébraux dans laquelle surviennent précocement des lésions de la substance blanche cérébrale qui… (more)

▼ CADASIL est une forme héréditaire, autosomique dominante, de maladie des petits vaisseaux cérébraux dans laquelle surviennent précocement des lésions de la substance blanche cérébrale qui progressent avec le temps, mais dont la nature histopathologique demeure très mal connue. La maladie est causée par des mutations très stéréotypées du récepteur Notch3. Une des signatures de CADASIL est la présence, dans les vaisseaux, d’une accumulation du domaine extracellulaire de NOTCH3 (Notch3ECD). Un faisceau d’arguments suggère que le processus pathogène de CADASIL résulte d’un effet toxique de ces dépôts de Notch3ECD, qui passerait par l’accumulation avec le NOTCH3ECD d’autres protéines de la matrice extracellulaire. Il a cependant été montré que des mutations CADASIL affectent les capacités de signalisation du récepteur, de manière constitutive ou avec le temps, ce qui a conduit à formuler l’hypothèse qu’une perte de fonction Notch3 pourrait également constituer un déterminant important du processus pathogène.Nous avons réalisé une analyse détaillée des lésions de la substance blanche dans un modèle murin de la maladie CADASIL obtenu par surexpression d’un allèle Notch3 avec la mutation R169C / R170C, qui en récapitule les stades précliniques (TgPACNotch3R169C). Ceci a permis de mettre en évidence aux stades précoces un oedème intramyélinique associé à une dégradation / décompaction de la myéline détectable en immunohistochimie dès l’âge de 6 mois. L’analyse de l’intégrité axonale au sein des lésions de la myéline suggère une perte secondaire. Une méthode de quantification semi-automatisée des débris myélinique a été élaborée.Nous avons ensuite testé l’hypothèse qu’une perte de fonction Notch3 pourrait constituer un déterminant majeur dans le processus pathogène de CADASIL. Nous avons pour cela identifié un set de gènes dont l’expression est sensible à la quantité de Notch3, capable de détecter une diminution de moitié de la dose de Notch3. La mesure de l’expression de ces gènes chez des souris Knock-in pour la mutation R170C, hétérozygotes ou homozygotes, a montré que l’activité Notch3 n’était pas diminuée dans ce modèle. Nous avons ensuite étudié l’impact de la suppression des copies endogènes de Notch3 sur les lésions de la substance blanche chez les souris TgPACNotch3R169C, qui n’apparaissent pas aggravées. Ces résultats plaident contre un effet hypomorphe commun à toutes les mutations CADASIL et suggèrent que les lésions de la substance blanche ne sont pas secondaires à un tel effet.Nous avons enfin étudié le rôle pathogène de l’excès de TIMP3 et vitronectine, deux protéines dont il a été démontré qu’elles s’accumulent précocement avec le NOTCH3ECD. En utilisant des approches d’interaction génétique (diminution et/ou augmentation de la quantité de TIMP3 et vitronectine chez les souris TgPACNotch3R169C), nous avons observé un effet différent de l’excès des deux protéines sur les anomalies de la réactivité cérébrovasculaire et celles de la substance blanche. En effet, la réduction de la quantité de vitronectine limite… Advisors/Committee Members: Joutel, Anne (thesis director).

Subjects/Keywords: Leucopathie; White matter lésions; Ischemic stroke

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Cognat, E. (2016). Lésions de la substance blanche dans la maladie CADASIL : White matter lesions in CADASIL. (Doctoral Dissertation). Sorbonne Paris Cité. Retrieved from http://www.theses.fr/2016USPCC139

Chicago Manual of Style (16^th Edition):

Cognat, Emmanuel. “Lésions de la substance blanche dans la maladie CADASIL : White matter lesions in CADASIL.” 2016. Doctoral Dissertation, Sorbonne Paris Cité. Accessed January 19, 2021. http://www.theses.fr/2016USPCC139.

MLA Handbook (7^th Edition):

Cognat, Emmanuel. “Lésions de la substance blanche dans la maladie CADASIL : White matter lesions in CADASIL.” 2016. Web. 19 Jan 2021.

Vancouver:

Cognat E. Lésions de la substance blanche dans la maladie CADASIL : White matter lesions in CADASIL. [Internet] [Doctoral dissertation]. Sorbonne Paris Cité; 2016. [cited 2021 Jan 19]. Available from: http://www.theses.fr/2016USPCC139.

Council of Science Editors:

Cognat E. Lésions de la substance blanche dans la maladie CADASIL : White matter lesions in CADASIL. [Doctoral Dissertation]. Sorbonne Paris Cité; 2016. Available from: http://www.theses.fr/2016USPCC139

University of Connecticut

13. Truong, Dongnhu. Deficits in Auditory, Cognitive, and Motor Processing Following Reversible MCAO in Mice: Understanding the Human Stroke Phenotype.

Degree: MA, Psychology, 2011, University of Connecticut

URL: https://opencommons.uconn.edu/gs_theses/61

► Stoke is characterized by a loss or alteration in neurological and/or bodily function resulting from a cerebral vascular accident (interruption of blood flow to… (more)

▼ Stoke is characterized by a loss or alteration in neurological and/or bodily function resulting from a cerebral vascular accident (interruption of blood flow to the brain). Acute ischemic stroke is the third leading cause of death in the United States, and the leading cause of long-term functional disability in adults. Stroke-induced deficits may include various forms of aphasia (language loss), cognitive deficits (including attentional and memory impairments), and motor impairments. Through the use of animal models, researchers can experimentally induce “stroke-like” injuries comparable to those seen in clinical populations. Such models allow us to study and understand the neurophysiological, anatomical, and neurobehavioral consequences associated with ischemic insults to the brain. Middle cerebral artery occlusion (MCAO) can be induced in rodents, and is a widely used experimental technique to model focal ischemia in rodents. Various neurobehavioral tasks have been developed to assess the motor and cognitive dysfunctions associated with MCAO in rodents, and these studies have shown deficits related to impaired long-term sensorimotor function, as well as retention of spatial memory. The current study was designed to develop a more comprehensive neurobehavioral profile associated with experimental focal cerebral ischemia induced by transient MCAO in adult C57Bl/6 mice. Using a modified pre-pulse inhibition auditory discrimination paradigm, and other tasks thought to tap language-related processing, mice subjected to 60 minute MCAO or Sham injury were assessed. These tasks were selected based on evidence that rapid auditory processing (RAP) skills are associated with language processing indices in clinical populations, as well as infant research showing that early RAP scores are predictive of language development. Importantly, deficits in the encoding of temporal sound features have also been associated with deficits in speech perception in elderly listeners and aphasics. In addition, cognitive and sensorimotor ability was also evaluated using the Morris water maze, non-spatial water maze, and rotarod task. Combined behavioral results from post-MCAO mice provide evidence of a RAP deficit (suggesting “aphasia-like” deficits), and deficits in learning and memory, as well as sensorimotor function. Overall results support the ongoing use of MCAO mice as a valid model to study ischemic stroke in humans, and further suggest that language-related tasks can be used to model “aphasia-like” deficits in rodents. Advisors/Committee Members: Etan J. Markus, Louise D. McCullough, Roslyn H. Fitch.

Subjects/Keywords: Aphasia; Ischemic Stroke; Rapid Auditory Processing; MCAO

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Truong, D. (2011). Deficits in Auditory, Cognitive, and Motor Processing Following Reversible MCAO in Mice: Understanding the Human Stroke Phenotype. (Masters Thesis). University of Connecticut. Retrieved from https://opencommons.uconn.edu/gs_theses/61

Chicago Manual of Style (16^th Edition):

Truong, Dongnhu. “Deficits in Auditory, Cognitive, and Motor Processing Following Reversible MCAO in Mice: Understanding the Human Stroke Phenotype.” 2011. Masters Thesis, University of Connecticut. Accessed January 19, 2021. https://opencommons.uconn.edu/gs_theses/61.

MLA Handbook (7^th Edition):

Truong, Dongnhu. “Deficits in Auditory, Cognitive, and Motor Processing Following Reversible MCAO in Mice: Understanding the Human Stroke Phenotype.” 2011. Web. 19 Jan 2021.

Vancouver:

Truong D. Deficits in Auditory, Cognitive, and Motor Processing Following Reversible MCAO in Mice: Understanding the Human Stroke Phenotype. [Internet] [Masters thesis]. University of Connecticut; 2011. [cited 2021 Jan 19]. Available from: https://opencommons.uconn.edu/gs_theses/61.

Council of Science Editors:

Truong D. Deficits in Auditory, Cognitive, and Motor Processing Following Reversible MCAO in Mice: Understanding the Human Stroke Phenotype. [Masters Thesis]. University of Connecticut; 2011. Available from: https://opencommons.uconn.edu/gs_theses/61

14. Arabadzhieva, Daniela / Арабаджиева, Даниела. Prevention of ischemic stroke and associated cardiovascular and metabolic diseases//Превенция на исхемичния мозъчен инсулт и свързаните сърдечносъдови и метаболитни заболявания.

Degree: 2014, Medical University of Varna

URL: http://repository.mu-varna.bg/handle/nls/55

►

[EN] During the recent decade, morbidity and mortality rates of most common cerebrovascular diseases continuously increase worldwide and in our country, too. Modern preventive approach… (more)

▼

[EN] During the recent decade, morbidity and mortality rates of most common cerebrovascular diseases continuously increase worldwide and in our country, too. Modern preventive approach is called upon helping the performance of effective strategies and tactics for identification of the role of cardiovascular and metabolic diseases the practical implementation of primary and secondary prevention of ischemic stroke (IS). The purpose of the study was to examine the diagnostic and prognostic importance of the concrete risk factors for IS. A total of 258 patients with acute IS in St. Marina University of Varna at a mean age of 71 years were analyzed concerning numerous metabolic laboratory parameters, nine cardiovascular diseases such as arterial hypertension, hypertensive heart, coronary atherosclerosis, ischemic heart disease, effort angina pectoris, myocardial infarction, atrial fibrillation, ventricular tachyarrhythmia, heart failure and diabetes mellitus and hyperglycemia, respectively. A differently manifested correlations between patient’s gender and age, number of accompanying diseases, laboratory parameter, Doppler sonography findings and modifiable risk factors for IS were established. The combination in one and the same patient of four and more cardiovascular diseases, especially of arterial hypertension and cardiac arrhythmias, related to the increased risk for IS. The parameters of glucose and lipid metabolism could be used with a diagnostic and prognostic purpose among the patients with suspected primary or relapsing IS within the system of primary and hospital aid in Bulgaria.

[BG] Заболяемостта и смъртността от най-честите мозъчно-съдови заболявания през последното десетилетие продължават да нарастват в световен мащаб и у нас. Съвременният профилактичен подход е призван да подпомогне провеждането на ефективни стратегии и тактики за идентифициране на ролята на сърдечно-съдовите и метаболитни заболявания и практическото осъществяване на първичната и вторична профилактика на исхемичния мозъчен инсулт (ИМИ). Целта на изследването е да се проучи диагностичното и прогностично значение на конкретните рискови фактори за ИМИ. Анализирани са 258 болни с остър ИМИ от УМБАЛ „Св. Марина“-Варна на средна възраст от 71 г., по отношение на голям брой лабораторни метаболитни показатели, девет сърдечно-съдови заболявания: хипертонична болест, хипертонично сърце, коронарна атеросклероза, исхемична болест на сърцето, ангина пекторис при усилие, миокарден инфаркт, предсърдно мъждене, камерна тахиаритмия, сърдечна недостатъчност, както и на захарен диабет, респ. хипергликемия. Установяват се различно изразени корелации между пола и възрастта на болните, броя на придружаващите заболявания, лабораторните показатели, Доплер-сонографските находки и модифицируемите рискови фактори за ИМИ. Съчетаването при един и същ болен на четири и повече сърдечно-съдови заболявания, особено на хипертоничната болест и сърдечните аритмии е свързано с повишен риск за ИМИ. Показателите на глюкозния и липиден метаболизъм могат да се използват с…

Subjects/Keywords: ischemic stroke; cardiovascular; metabolic; cerebrovascular; Неврология / Neurology

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Arabadzhieva, Daniela / Арабаджиева, �. (2014). Prevention of ischemic stroke and associated cardiovascular and metabolic diseases//Превенция на исхемичния мозъчен инсулт и свързаните сърдечносъдови и метаболитни заболявания. (Thesis). Medical University of Varna. Retrieved from http://repository.mu-varna.bg/handle/nls/55

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Arabadzhieva, Daniela / Арабаджиева, Даниела. “Prevention of ischemic stroke and associated cardiovascular and metabolic diseases//Превенция на исхемичния мозъчен инсулт и свързаните сърдечносъдови и метаболитни заболявания.” 2014. Thesis, Medical University of Varna. Accessed January 19, 2021. http://repository.mu-varna.bg/handle/nls/55.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Arabadzhieva, Daniela / Арабаджиева, Даниела. “Prevention of ischemic stroke and associated cardiovascular and metabolic diseases//Превенция на исхемичния мозъчен инсулт и свързаните сърдечносъдови и метаболитни заболявания.” 2014. Web. 19 Jan 2021.

Vancouver:

Arabadzhieva, Daniela / Арабаджиева �. Prevention of ischemic stroke and associated cardiovascular and metabolic diseases//Превенция на исхемичния мозъчен инсулт и свързаните сърдечносъдови и метаболитни заболявания. [Internet] [Thesis]. Medical University of Varna; 2014. [cited 2021 Jan 19]. Available from: http://repository.mu-varna.bg/handle/nls/55.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Arabadzhieva, Daniela / Арабаджиева �. Prevention of ischemic stroke and associated cardiovascular and metabolic diseases//Превенция на исхемичния мозъчен инсулт и свързаните сърдечносъдови и метаболитни заболявания. [Thesis]. Medical University of Varna; 2014. Available from: http://repository.mu-varna.bg/handle/nls/55

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

15. Andonova, Silva / Андонова, Силва. Treatment of acute ischemic stroke with intravenous thrombolysis: prospective studies on the outcome of the disease// Лечение на острия исхемичен мозъчен инсулт с интравенозна тромболиза: проспективни проучвания върху изхода от болестта.

Degree: 2015, Medical University of Varna

URL: http://repository.mu-varna.bg/handle/nls/51

► [EN] The dissertation work is devoted to contemporary and topical issue in neuroscience - prospective study of the outcome of the disease after a differentiated… (more)

▼ [EN] The dissertation work is devoted to contemporary and topical issue in neuroscience - prospective study of the outcome of the disease after a differentiated / with intravenous thrombolysis / or undifferentiated treatment of acute ischemic stroke / OIMI /. It is the first systematic scientific work in Bulgaria, which compares the two therapeutic approaches used to treat OIMI. The topicality of the theme is in line with the ongoing reform in the Bulgarian healthcare that focuses on differentiated approach to the treatment of strokes and improve the quality of medical care. The dissertation work is the first scientific relatively prospective country analyzing early and late / to third month / out of the disease in patients treated with / without intravenous thrombolysis / TL /. It was conducted in a large cohort of 1698 patients with OIMI, of which - 166 were differentially thrombolytic therapy and 1532 - a standard treatment without thrombolysis . All patients were hospitalized in the second clinic of nevrology with ICU for at the University Hospital "St. Marina "- Varna during 2009 Miss 2013. They are chosen strictly defined inclusion and exclusion criteria. The results concerning the search for predictors of a better outcome than OIMI are confirmatory. In both patient groups they are associated with young age, lack of CT ischemic changes in brain parenchyma and the presence of a mild focal neurological symptoms in hospitalized, evaluated with NIHSS scale / 0-5 /. Confirmed the presence of significant indicators of increased risk of intracerebral hematoma as a complication of treatment TL. They include start TL treatment after the third hour of stroke onset, CT data leukoencephalopathy, neurological deficit over 19 on the scale NIHSS on admission. Of fundamental interest are comparative results between the two groups associated with the evaluation of early and late / on third month / functional independence after OIMI. It was found that at hospital discharge patients with TL had significantly better functional independence Rankin scale compared to the group without TL, which is more pronounced in cases with early initiation of TL and a light source / in hospitalization / neurological deficit . On the third month of stroke onset, the two groups / with or without TL / show similar functional recovery. These results support the hypothesis that the recovery after stroke follows certain laws, including independent treatment nonlinear processes of spontaneous recovery within the first 3-6 months of stroke - they relate to biological recovery in the acute period as a result of spontaneous or therapeutic recanalization followed by complex processes of brain reorganization by engaging new synapses, neural networks and others.With an original character is the establishment of a set of clinical quality indicators, including: percentage held thrombolysis average time from entry into the emergency room to start of treatment, mean duration of hospital stay, hospital mortality and mortality / disability of the third month of…

Subjects/Keywords: ischemic stroke; intravenous thrombolysis; Неврология / Neurology

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Andonova, Silva / Андонова, �. (2015). Treatment of acute ischemic stroke with intravenous thrombolysis: prospective studies on the outcome of the disease// Лечение на острия исхемичен мозъчен инсулт с интравенозна тромболиза: проспективни проучвания върху изхода от болестта. (Thesis). Medical University of Varna. Retrieved from http://repository.mu-varna.bg/handle/nls/51

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Andonova, Silva / Андонова, Силва. “Treatment of acute ischemic stroke with intravenous thrombolysis: prospective studies on the outcome of the disease// Лечение на острия исхемичен мозъчен инсулт с интравенозна тромболиза: проспективни проучвания върху изхода от болестта.” 2015. Thesis, Medical University of Varna. Accessed January 19, 2021. http://repository.mu-varna.bg/handle/nls/51.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Andonova, Silva / Андонова, Силва. “Treatment of acute ischemic stroke with intravenous thrombolysis: prospective studies on the outcome of the disease// Лечение на острия исхемичен мозъчен инсулт с интравенозна тромболиза: проспективни проучвания върху изхода от болестта.” 2015. Web. 19 Jan 2021.

Vancouver:

Andonova, Silva / Андонова �. Treatment of acute ischemic stroke with intravenous thrombolysis: prospective studies on the outcome of the disease// Лечение на острия исхемичен мозъчен инсулт с интравенозна тромболиза: проспективни проучвания върху изхода от болестта. [Internet] [Thesis]. Medical University of Varna; 2015. [cited 2021 Jan 19]. Available from: http://repository.mu-varna.bg/handle/nls/51.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Andonova, Silva / Андонова �. Treatment of acute ischemic stroke with intravenous thrombolysis: prospective studies on the outcome of the disease// Лечение на острия исхемичен мозъчен инсулт с интравенозна тромболиза: проспективни проучвания върху изхода от болестта. [Thesis]. Medical University of Varna; 2015. Available from: http://repository.mu-varna.bg/handle/nls/51

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Adelaide

16. Leong, Wai Khay. Stem cell and molecular investigations following focal cerebral ischemia.

Degree: 2012, University of Adelaide

URL: http://hdl.handle.net/2440/87114

► This thesis revolves around a general theme – cerebral ischemia. Stroke is the second leading cause of mortality after cardiovascular disease and the single primary… (more)

▼ This thesis revolves around a general theme – cerebral ischemia. Stroke is the second leading cause of mortality after cardiovascular disease and the single primary cause of long-term adult disability worldwide. The number of stroke victims will only continue to rise due to the ageing population. Two out of three stroke patients survive the insult; however, neurological deficits which ensue are often debilitating and devastating. Chapter 1 presents a review of literature on the pathophysiology of ischemic stroke as well as on preclinical stroke research which underlies studies undertaken in this thesis. Current ischemic stroke treatment regimens are not without their respective limitations, hence alternative, more effective, strategies are being developed to improve post-stroke functional recovery. One such approach is cell-based therapy involving the transplantation of exogenous stem/progenitor cells. Chapter 2 demonstrates the therapeutic efficacy of adult human dental pulp stem cells (DPSCs), a novel population of stem cells isolated from wisdom teeth, following intracerebral transplantation in a rodent model of focal cerebral ischemia. Significant improvement in forelimb sensorimotor function was observed at 4 weeks post-treatment, along with targeted migration of grafted cells toward the infarct area and minimal cell survival in the host brain. This suggests that human DPSCs are likely to mediate post-stroke neurobehavioral improvement via mechanisms other than endogenous neural cell replacement. The onset of cerebral ischemia triggers a cascade of molecular events in the brain including the expression of early response transcription factors, one of which being the neuronal Per-Arnt-Sim domain protein 4 (Npas4). Although Npas4 transcript levels have been reported to be robustly upregulated following an ischemic insult, little is known of its role in cerebral ischemia. Chapter 3 addresses this by characterizing the in vivo neuroanatomical expression profile of the Npas4 protein in a rat stroke model. Focal cerebral ischemia induced an early, transient and robust upregulation of Npas4 with a unique differential expression pattern in corticolimbic regions of the rodent brain which critically subserve cognitive and emotional functions, thus implying that Npas4 may play a role in post-stroke cognitive and emotional symptoms, prevalent stroke-associated neurological deficits with detrimental effects on functional recovery. Previous studies have implicated Npas4 in the protection of neuronal cells against excitotoxic stimuli and apoptotic stress per se but not in the context of stroke. Chapter 4 further examines a possible role for Npas4 in neuroprotection following cerebral ischemia using a loss-of-function approach in an in vitro model of primary cultured cortical neurons subjected to oxygen and glucose deprivation (OGD). Knockdown of Npas4 expression led to decreased cell viability as well as increased neurite and dendrite fragmentation following an OGD insult. These findings are suggestive of the involvement of… Advisors/Committee Members: Koblar, Simon Andrea (advisor), Lewis, Martin David (advisor), School of Molecular and Biomedical Science (school).

Subjects/Keywords: cell-based therapy; Npas4; ischemic stroke

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Leong, W. K. (2012). Stem cell and molecular investigations following focal cerebral ischemia. (Thesis). University of Adelaide. Retrieved from http://hdl.handle.net/2440/87114

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Leong, Wai Khay. “Stem cell and molecular investigations following focal cerebral ischemia.” 2012. Thesis, University of Adelaide. Accessed January 19, 2021. http://hdl.handle.net/2440/87114.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Leong, Wai Khay. “Stem cell and molecular investigations following focal cerebral ischemia.” 2012. Web. 19 Jan 2021.

Vancouver:

Leong WK. Stem cell and molecular investigations following focal cerebral ischemia. [Internet] [Thesis]. University of Adelaide; 2012. [cited 2021 Jan 19]. Available from: http://hdl.handle.net/2440/87114.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Leong WK. Stem cell and molecular investigations following focal cerebral ischemia. [Thesis]. University of Adelaide; 2012. Available from: http://hdl.handle.net/2440/87114

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Tampere University

17. Järvenpää, Soila. Neuropsychological Evaluation of Young Adults with Ischemic Stroke .

Degree: 2017, Tampere University

URL: https://trepo.tuni.fi/handle/10024/100811

► Background and purpose: The neuropsychological profile of young stroke patients is a relatively underinvestigated subject. As the etiology, risk factors, stroke subtypes, and stroke severity… (more)

Subjects/Keywords: ischemic stroke; young adults; neuropsychology; neuropsychological evaluation

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APA (6^th Edition):

Järvenpää, S. (2017). Neuropsychological Evaluation of Young Adults with Ischemic Stroke . (Masters Thesis). Tampere University. Retrieved from https://trepo.tuni.fi/handle/10024/100811

Chicago Manual of Style (16^th Edition):

Järvenpää, Soila. “Neuropsychological Evaluation of Young Adults with Ischemic Stroke .” 2017. Masters Thesis, Tampere University. Accessed January 19, 2021. https://trepo.tuni.fi/handle/10024/100811.

MLA Handbook (7^th Edition):

Järvenpää, Soila. “Neuropsychological Evaluation of Young Adults with Ischemic Stroke .” 2017. Web. 19 Jan 2021.

Vancouver:

Järvenpää S. Neuropsychological Evaluation of Young Adults with Ischemic Stroke . [Internet] [Masters thesis]. Tampere University; 2017. [cited 2021 Jan 19]. Available from: https://trepo.tuni.fi/handle/10024/100811.

Council of Science Editors:

Järvenpää S. Neuropsychological Evaluation of Young Adults with Ischemic Stroke . [Masters Thesis]. Tampere University; 2017. Available from: https://trepo.tuni.fi/handle/10024/100811

University of Missouri – Columbia

18. Xie, Yicheng. The role of astrocytic calcium signaling in brain damage after photothrombosis.

Degree: 2011, University of Missouri – Columbia

URL: http://hdl.handle.net/10355/35146

► [ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Ischemic stroke is the third leading cause of death in industrialized countries. Our previous… (more)

▼ [ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Ischemic stroke is the third leading cause of death in industrialized countries. Our previous study found elevated [Ca[superscript 2+]]i signals in astrocytes after photothrombosis-induced ischemia. However, the role of astrocytic Ca[superscript 2+] signaling in ischemia is still poorly understood. In this study, we generated a stable and repeatable photothrombosis-induced ischemia model so that its ischemic infarction could be controlled by regulating the intensity of the output light and the size of the irradiated area in the cortex, which could be used to study the mechanisms of tissue damage and neuronal protection. Secondly, we investigated the effect of the Pleckstrin Homology (PH) domain of Phospholipase C (PLC)-like protein p130 (p130PH) on Ca[superscript 2+] signaling in astrocytes in vivo. We used the serotype 2/5 recombinant adeno-associated virus (rAV2/5) vectors to introduce p130PH fused with a tagged protein monomer red fluorescent protein at the N-terminal (i.e., transgene mRFP-p130PH). In order to selectively disrupt the Ca[superscript 2+] signaling pathway in astrocytes, the transgene was driven by a novel astrocyte-specific promoter gfaABC1D. Our results show that mRFP-p130PH is exclusively expressed in astrocytes with a high efficiency and a stable expression level. In vivo imaging using two-photon microscopy demonstrated reduced Ca[superscript 2+] signal in transduced astrocytes in response to ATP simulation. As Ca[superscript 2+] signaling is a characteristic form of cellular excitability in astrocytes that can mediate chemical transmitter release and contribute to neuronal excitotoxicity, the current study provides an in vivo approach to better understand Ca[superscript 2+]-dependent gliotransmission and its involvement in glia related diseases (i.e., ischemia). In order to study the role of astrocytic Ca[superscript 2+] signaling in ischemia, we tested the photothrombosis ischemic model on IP[subscript 3]R2 knockout mice. First, we demonstrated that IP[subscript 3]R2 knockout mice depleted astrocytic IP[subscript 3]R in vivo, but also abolished IP[subscript 3] mediated astrocytic [Ca[superscript 2+]]i signaling in response to ATP using in vivo imaging. Between WT and IP[subscript 3]R2 knockout mice, there is no difference in the number of astrocytes number and expression of specific astrocytic proteins which have been demonstrated to be crucial in ischemia damage. At 24 hours after photothrombosis-induced ischemia, we found a similar size of infarct volume and neuronal response between WT and IP[subscript 3]R2 knockout mice. The same phenomena were observed at 2 days and 7 days after ischemia. Until day 14 after ischemia, we discovered smaller infarct volume in IP[subscript 3]R2 knockout mice than WT mice, with more shrinking tissue around the ischemic core in the IP[subscript 3]R2 knockout mice. Further investigation demonstrated that the IP[subscript 3]R2 knockout mice have more severe glia scar formation and microglia… Advisors/Committee Members: Ding, Shinghua (advisor).

Subjects/Keywords: ischemic stroke; photothrombosis-induced ischemia; astrocytes

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APA (6^th Edition):

Xie, Y. (2011). The role of astrocytic calcium signaling in brain damage after photothrombosis. (Thesis). University of Missouri – Columbia. Retrieved from http://hdl.handle.net/10355/35146

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Xie, Yicheng. “The role of astrocytic calcium signaling in brain damage after photothrombosis.” 2011. Thesis, University of Missouri – Columbia. Accessed January 19, 2021. http://hdl.handle.net/10355/35146.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Xie, Yicheng. “The role of astrocytic calcium signaling in brain damage after photothrombosis.” 2011. Web. 19 Jan 2021.

Vancouver:

Xie Y. The role of astrocytic calcium signaling in brain damage after photothrombosis. [Internet] [Thesis]. University of Missouri – Columbia; 2011. [cited 2021 Jan 19]. Available from: http://hdl.handle.net/10355/35146.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Xie Y. The role of astrocytic calcium signaling in brain damage after photothrombosis. [Thesis]. University of Missouri – Columbia; 2011. Available from: http://hdl.handle.net/10355/35146

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Alberta

19. Hafermehl, Kyle T. High Spatial Resolution Diffusion-Weighted Imaging (DWI) of Ischemic Stroke and Transient Ischemic Attack (TIA).

Degree: MS, Centre for Neuroscience, 2016, University of Alberta

URL: https://era.library.ualberta.ca/files/cq524jn99g

► Diffusion-weighted imaging (DWI) is the most sensitive imaging technique available to identify ischemic lesions. This magnetic resonance imaging (MRI) technique exploits (non-invasively and in a… (more)

▼ Diffusion-weighted imaging (DWI) is the most sensitive imaging technique available to identify ischemic lesions. This magnetic resonance imaging (MRI) technique exploits (non-invasively and in a short scan time) early changes to water mobility caused by metabolic failure of neurons by tagging water molecules and tracking their movement, enabling DWI to detect diffusion restriction (interpreted to indicate infarction in ischemic stroke) within minutes of symptom manifestation. Ischemic stroke and transient ischemic attack are an increasingly diagnosed affliction of the cerebrovascular system causing both death and loss of independence, relying on the utilization of neuroimaging to assist in identification of infarctions and probable etiology in order to initiate the most effective treatment path. But clinical DWI is still obtained using resolution that is insufficient to identify small ischemic lesions in minor ischemic stroke and transient ischemic attack (TIA). The experiment within this thesis utilized high spatial resolution DWI sequence to detect ischemic lesions present within acute ischemic stroke and transient ischemic attack patients (n = 48). The decreased voxel size (4.7T, 3.4 mm3; 1.5T, 4.5 mm3; 3.0T, 3.4 mm3) and slice thickness (4.7T, 1.5 mm; 1.5T, 2 mm; 3.0T, 1.5 mm) was achieved at the expense of additional time (4.7T, 210 s; 1.5T, 293 s; 3.0T, 259 s) and incorporated into the stroke protocol on 1.5T, 3T and 4.7T magnetic field strength scanners. Ischemic lesions were identified on the high resolution DWI (n = 94) that remained undetected on lower spatial resolution DWI (n = 65) typically utilized on clinical scanners. Undetected ischemic lesions (n = 29) were very small and more often located within the cortex. Ischemic lesions were consistently measured to be smaller in volume and demonstrated decreased apparent diffusion coefficient values on the high resolution DWI by reducing partial volume effects with adjacent non infarcted tissue. Improving the spatial resolution of diffusion-weighted imaging sequences and taking advantage of high magnetic fields, improves patient diagnosis and potentially their prognosis by accurate assessment of ischemic lesion patterns and lesion volume and mean diffusivity (MD) estimation. Future work is necessary to combine the high resolution diffusion imaging acquisition parameters used in this thesis with high resolution MRI modalities that evaluate tissue perfusion in order to systematically study transient ischemic attack longitudinally and identify permanent tissue damage.

Subjects/Keywords: Transient ischemic attack; Diffusion-weighted imaging; Ischemic stroke

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APA (6^th Edition):

Hafermehl, K. T. (2016). High Spatial Resolution Diffusion-Weighted Imaging (DWI) of Ischemic Stroke and Transient Ischemic Attack (TIA). (Masters Thesis). University of Alberta. Retrieved from https://era.library.ualberta.ca/files/cq524jn99g

Chicago Manual of Style (16^th Edition):

Hafermehl, Kyle T. “High Spatial Resolution Diffusion-Weighted Imaging (DWI) of Ischemic Stroke and Transient Ischemic Attack (TIA).” 2016. Masters Thesis, University of Alberta. Accessed January 19, 2021. https://era.library.ualberta.ca/files/cq524jn99g.

MLA Handbook (7^th Edition):

Hafermehl, Kyle T. “High Spatial Resolution Diffusion-Weighted Imaging (DWI) of Ischemic Stroke and Transient Ischemic Attack (TIA).” 2016. Web. 19 Jan 2021.

Vancouver:

Hafermehl KT. High Spatial Resolution Diffusion-Weighted Imaging (DWI) of Ischemic Stroke and Transient Ischemic Attack (TIA). [Internet] [Masters thesis]. University of Alberta; 2016. [cited 2021 Jan 19]. Available from: https://era.library.ualberta.ca/files/cq524jn99g.

Council of Science Editors:

Hafermehl KT. High Spatial Resolution Diffusion-Weighted Imaging (DWI) of Ischemic Stroke and Transient Ischemic Attack (TIA). [Masters Thesis]. University of Alberta; 2016. Available from: https://era.library.ualberta.ca/files/cq524jn99g

NSYSU

20. Hsu, Yi-Ting. A Study on the Levels of Heavy Metals in Patients with Acute Ischemic Stroke.

Degree: Master, Biological Sciences, 2017, NSYSU

URL: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0721117-110326

► Few studies examining the relationship between heavy metal amounts and stroke incidence have been reported. The aim of this study was to explore the relationship… (more)

Subjects/Keywords: acute ischemic stroke; heavy metal; stroke; lead; arsenic; cadmium; mercury

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APA (6^th Edition):

Hsu, Y. (2017). A Study on the Levels of Heavy Metals in Patients with Acute Ischemic Stroke. (Thesis). NSYSU. Retrieved from http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0721117-110326

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Hsu, Yi-Ting. “A Study on the Levels of Heavy Metals in Patients with Acute Ischemic Stroke.” 2017. Thesis, NSYSU. Accessed January 19, 2021. http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0721117-110326.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Hsu, Yi-Ting. “A Study on the Levels of Heavy Metals in Patients with Acute Ischemic Stroke.” 2017. Web. 19 Jan 2021.

Vancouver:

Hsu Y. A Study on the Levels of Heavy Metals in Patients with Acute Ischemic Stroke. [Internet] [Thesis]. NSYSU; 2017. [cited 2021 Jan 19]. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0721117-110326.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Hsu Y. A Study on the Levels of Heavy Metals in Patients with Acute Ischemic Stroke. [Thesis]. NSYSU; 2017. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0721117-110326

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Toronto

21. Vesely, Kristin Aileen. Driving Performance and Underlying Brain Activation Patterns in Chronic Stroke Patients.

Degree: 2016, University of Toronto

URL: http://hdl.handle.net/1807/76066

►

Resuming driving is an important priority for many stroke patients, yet persistent deficits may result in impaired driving performance. The present study used driving simulation… (more)

Subjects/Keywords: Driving; fMRI; Ischemic Stroke; Stroke; Subarachnoid Hemorrhage; 0564

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APA (6^th Edition):

Vesely, K. A. (2016). Driving Performance and Underlying Brain Activation Patterns in Chronic Stroke Patients. (Masters Thesis). University of Toronto. Retrieved from http://hdl.handle.net/1807/76066

Chicago Manual of Style (16^th Edition):

Vesely, Kristin Aileen. “Driving Performance and Underlying Brain Activation Patterns in Chronic Stroke Patients.” 2016. Masters Thesis, University of Toronto. Accessed January 19, 2021. http://hdl.handle.net/1807/76066.

MLA Handbook (7^th Edition):

Vesely, Kristin Aileen. “Driving Performance and Underlying Brain Activation Patterns in Chronic Stroke Patients.” 2016. Web. 19 Jan 2021.

Vancouver:

Vesely KA. Driving Performance and Underlying Brain Activation Patterns in Chronic Stroke Patients. [Internet] [Masters thesis]. University of Toronto; 2016. [cited 2021 Jan 19]. Available from: http://hdl.handle.net/1807/76066.

Council of Science Editors:

Vesely KA. Driving Performance and Underlying Brain Activation Patterns in Chronic Stroke Patients. [Masters Thesis]. University of Toronto; 2016. Available from: http://hdl.handle.net/1807/76066

University of Toronto

22. Vesely, Kristin Aileen. Driving Performance and Underlying Brain Activation Patterns in Chronic Stroke Patients.

Degree: 2016, University of Toronto

URL: http://hdl.handle.net/1807/76089

►

Resuming driving is an important priority for many stroke patients, yet persistent deficits may result in impaired driving performance. The present study used driving simulation… (more)

Subjects/Keywords: Driving; fMRI; Ischemic Stroke; Stroke; Subarachnoid Hemorrhage; 0564

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Vesely, K. A. (2016). Driving Performance and Underlying Brain Activation Patterns in Chronic Stroke Patients. (Masters Thesis). University of Toronto. Retrieved from http://hdl.handle.net/1807/76089

Chicago Manual of Style (16^th Edition):

Vesely, Kristin Aileen. “Driving Performance and Underlying Brain Activation Patterns in Chronic Stroke Patients.” 2016. Masters Thesis, University of Toronto. Accessed January 19, 2021. http://hdl.handle.net/1807/76089.

MLA Handbook (7^th Edition):

Vesely, Kristin Aileen. “Driving Performance and Underlying Brain Activation Patterns in Chronic Stroke Patients.” 2016. Web. 19 Jan 2021.

Vancouver:

Vesely KA. Driving Performance and Underlying Brain Activation Patterns in Chronic Stroke Patients. [Internet] [Masters thesis]. University of Toronto; 2016. [cited 2021 Jan 19]. Available from: http://hdl.handle.net/1807/76089.

Council of Science Editors:

Vesely KA. Driving Performance and Underlying Brain Activation Patterns in Chronic Stroke Patients. [Masters Thesis]. University of Toronto; 2016. Available from: http://hdl.handle.net/1807/76089

University of Toronto

23. Vesely, Kristin Aileen. Driving Performance and Underlying Brain Activation Patterns in Chronic Stroke Patients.

Degree: 2016, University of Toronto

URL: http://hdl.handle.net/1807/76145

►

Resuming driving is an important priority for many stroke patients, yet persistent deficits may result in impaired driving performance. The present study used driving simulation… (more)

Subjects/Keywords: Driving; fMRI; Ischemic Stroke; Stroke; Subarachnoid Hemorrhage; 0564

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Vesely, K. A. (2016). Driving Performance and Underlying Brain Activation Patterns in Chronic Stroke Patients. (Masters Thesis). University of Toronto. Retrieved from http://hdl.handle.net/1807/76145

Chicago Manual of Style (16^th Edition):

Vesely, Kristin Aileen. “Driving Performance and Underlying Brain Activation Patterns in Chronic Stroke Patients.” 2016. Masters Thesis, University of Toronto. Accessed January 19, 2021. http://hdl.handle.net/1807/76145.

MLA Handbook (7^th Edition):

Vesely, Kristin Aileen. “Driving Performance and Underlying Brain Activation Patterns in Chronic Stroke Patients.” 2016. Web. 19 Jan 2021.

Vancouver:

Vesely KA. Driving Performance and Underlying Brain Activation Patterns in Chronic Stroke Patients. [Internet] [Masters thesis]. University of Toronto; 2016. [cited 2021 Jan 19]. Available from: http://hdl.handle.net/1807/76145.

Council of Science Editors:

Vesely KA. Driving Performance and Underlying Brain Activation Patterns in Chronic Stroke Patients. [Masters Thesis]. University of Toronto; 2016. Available from: http://hdl.handle.net/1807/76145

University of Toronto

24. Vesely, Kristin Aileen. Driving Performance and Underlying Brain Activation Patterns in Chronic Stroke Patients.

Degree: 2016, University of Toronto

URL: http://hdl.handle.net/1807/76213

►

Resuming driving is an important priority for many stroke patients, yet persistent deficits may result in impaired driving performance. The present study used driving simulation… (more)

Subjects/Keywords: Driving; fMRI; Ischemic Stroke; Stroke; Subarachnoid Hemorrhage; 0564

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Vesely, K. A. (2016). Driving Performance and Underlying Brain Activation Patterns in Chronic Stroke Patients. (Masters Thesis). University of Toronto. Retrieved from http://hdl.handle.net/1807/76213

Chicago Manual of Style (16^th Edition):

Vesely, Kristin Aileen. “Driving Performance and Underlying Brain Activation Patterns in Chronic Stroke Patients.” 2016. Masters Thesis, University of Toronto. Accessed January 19, 2021. http://hdl.handle.net/1807/76213.

MLA Handbook (7^th Edition):

Vesely, Kristin Aileen. “Driving Performance and Underlying Brain Activation Patterns in Chronic Stroke Patients.” 2016. Web. 19 Jan 2021.

Vancouver:

Vesely KA. Driving Performance and Underlying Brain Activation Patterns in Chronic Stroke Patients. [Internet] [Masters thesis]. University of Toronto; 2016. [cited 2021 Jan 19]. Available from: http://hdl.handle.net/1807/76213.

Council of Science Editors:

Vesely KA. Driving Performance and Underlying Brain Activation Patterns in Chronic Stroke Patients. [Masters Thesis]. University of Toronto; 2016. Available from: http://hdl.handle.net/1807/76213

University of Cincinnati

25. Walsh, Kyle B. Plasma Biomarkers for Ischemic and Hemorrhagic Stroke Diagnosis.

Degree: MS, Medicine: Clinical and Translational Research, 2017, University of Cincinnati

URL: http://rave.ohiolink.edu/etdc/view?acc_num=ucin1511859455574062

► Background: Blood biomarkers for ischemic and hemorrhagic stroke diagnosis remain elusive. Recent investigations suggested that apolipoproteins (Apo), matrix metalloproteinases (MMP), and paraoxonase-1 may be associated… (more)

Subjects/Keywords: Neurology; Stroke; Ischemic Stroke; Intracerebral Hemorrhage; Biomarkers; Proteomics

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APA (6^th Edition):

Walsh, K. B. (2017). Plasma Biomarkers for Ischemic and Hemorrhagic Stroke Diagnosis. (Masters Thesis). University of Cincinnati. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=ucin1511859455574062

Chicago Manual of Style (16^th Edition):

Walsh, Kyle B. “Plasma Biomarkers for Ischemic and Hemorrhagic Stroke Diagnosis.” 2017. Masters Thesis, University of Cincinnati. Accessed January 19, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1511859455574062.

MLA Handbook (7^th Edition):

Walsh, Kyle B. “Plasma Biomarkers for Ischemic and Hemorrhagic Stroke Diagnosis.” 2017. Web. 19 Jan 2021.

Vancouver:

Walsh KB. Plasma Biomarkers for Ischemic and Hemorrhagic Stroke Diagnosis. [Internet] [Masters thesis]. University of Cincinnati; 2017. [cited 2021 Jan 19]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=ucin1511859455574062.

Council of Science Editors:

Walsh KB. Plasma Biomarkers for Ischemic and Hemorrhagic Stroke Diagnosis. [Masters Thesis]. University of Cincinnati; 2017. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=ucin1511859455574062

26. Strömberg, Sofia. Symptomatic Carotid Stenosis - optimal timing of surgical treatment.

Degree: 2017, University of Gothenburg / Göteborgs Universitet

URL: http://hdl.handle.net/2077/52862

► Abstract In patients with symptomatic carotid artery stenosis is convincing evidence that carotid endarterectomy (CEA) confers maximum benefit if performed within 14 days from index… (more)

▼ Abstract In patients with symptomatic carotid artery stenosis is convincing evidence that carotid endarterectomy (CEA) confers maximum benefit if performed within 14 days from index event. Patients with TIA or minor stroke have an increased risk of early recurrent stroke in the first weeks after the index event, then declining over months. This is the rationale to perform CEA as soon as possible after an index event. However, the procedural risk within the urgent time period is unknown. Aim The overall aim of this thesis was to investigate the optimal timing of surgical treatment in patients with symptomatic carotid stenosis. Methods In study I, registry data, obtained from Swedvasc, was analyzed regarding procedural risk of CEA, stratified for delay from index event. Mortality and stroke rate was studied at four time points, 0-2 days, 3-7 days, 8-14 days and 15-180 days. A multivariable analysis was performed to find other risk factors for CEA than time from referring event. In study II, 397 patients from WINGA, a region based registry for ultrasound investigations, were analyzed. All included patient had a significant symptomatic carotid stenosis. The risk of recurrent stroke at day 2, 7 and 30 after the index event was analyzed. Study III, was a prospective population based study with 418 consecutive patients comparing CEA within 48 hours with CEA after 48 hours to 14 days from most recent event. Primary endpoint was 30 days stroke and/or mortality rate after CEA. Study IV, included all CEA for symptomatic carotid stenosis registered in Swedvasc from May, 2008 to October, 2014. All medical records for CEA performed within 2 days were collected, and also a control group with CEA 3 to 7 days from index event. Analysis of validated and crude data regarding procedural risk stratified for delay was made. Optimal Timing of Surgical Treatment 6…,,,. Results The overall results from the four studies in the thesis shows an early risk of recurrent stroke at 1.7-2.0% day 2, 4% at one week and 7.5% at day 30. The procedural risk was 7.3-11.5% when CEA was performed within 2 days, 2.9-3.6% in patients with CEA 3 to 7 days, and 3.0-5.0% if surgery was performed 3 to 14 days after index event. Conclusions In summary, the procedural risk exceeds the risk of recurrent stroke day 0 to 2 in the studies in this thesis. The procedural risk, when 48 hours have elapsed after index event are not associated with an increased risk compared to even later surgery. This advocate a more expedited intervention than today’s guidelines recommend. The exception should be day 0 and 1, where only a minority of patients benefit from surgery. Keywords Carotid artery stenosis, carotid endarterectomy, stroke, transient ischemic attack, ocular transient ischemic attack

Subjects/Keywords: carotid endarterectomy; carotid artery stenosis; stroke; transient ischemic attack; ocular transient ischemic attack

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APA (6^th Edition):

Strömberg, S. (2017). Symptomatic Carotid Stenosis - optimal timing of surgical treatment. (Thesis). University of Gothenburg / Göteborgs Universitet. Retrieved from http://hdl.handle.net/2077/52862

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Strömberg, Sofia. “Symptomatic Carotid Stenosis - optimal timing of surgical treatment.” 2017. Thesis, University of Gothenburg / Göteborgs Universitet. Accessed January 19, 2021. http://hdl.handle.net/2077/52862.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Strömberg, Sofia. “Symptomatic Carotid Stenosis - optimal timing of surgical treatment.” 2017. Web. 19 Jan 2021.

Vancouver:

Strömberg S. Symptomatic Carotid Stenosis - optimal timing of surgical treatment. [Internet] [Thesis]. University of Gothenburg / Göteborgs Universitet; 2017. [cited 2021 Jan 19]. Available from: http://hdl.handle.net/2077/52862.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Strömberg S. Symptomatic Carotid Stenosis - optimal timing of surgical treatment. [Thesis]. University of Gothenburg / Göteborgs Universitet; 2017. Available from: http://hdl.handle.net/2077/52862

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Lund

27. Buchwald, Fredrik. TIA in the Swedish Stroke Register (Riksstroke). Aspects on diagnostic validation, risk factors, investigations, and therapies.

Degree: 2018, University of Lund

URL: https://lup.lub.lu.se/record/ffa6e154-2aa2-4574-bdf4-4dccc06e732e ; https://portal.research.lu.se/ws/files/39306259/kappan_mediatryck_2010205.pdf

► Background: Transient ischemic attacks (TIA) indicate an increased risk of stroke, one of the leading causes of death and disability worldwide. In order to prevent… (more)

▼ Background: Transient ischemic attacks (TIA) indicate an increased risk of stroke, one of the leading causes of death and disability worldwide. In order to prevent stroke, our knowledge of diagnosis, demographics, risk factors, investigations, and treatment of patients with TIA needs to be improved.Aims: The aims of this thesis were to validate data and diagnoses in the Riksstroke TIA module (Riksstroke-TIA), to clarify the role of atrial fibrillation (AF) in TIA and the extent of oral anticoagulant (OAC) treatment in patients with AF, to assess characteristics, risk factors, and secondary preventive treatment in TIA patients with a history of stroke in comparison to those without, and evaluate the degree of carotid imaging and determinants for its non-use in patients with TIA.Methods: Paper I was based on a study sample of 180 patients from 6 different hospitals, extracted from the cohort of patients registered in Riksstroke-TIA between 1/7/2011 to 30/6/2012 (n=7825). Medical files were retrieved from each hospital. Paper II – IV were based on data from patients registered in Riksstroke-TIA between 1/7/2011 to 30/6/2013 (n=15064). For comparison, data on patients with ischemic stroke (IS) registered in Riksstroke during the corresponding period of time were included in paper II – IV (n=44416).ResultsPaper I: Two independent assessors agreed on a likely or possible diagnosis of TIA in 77% (137/180), in 3% (5/180) on a diagnosis of IS, and in 2% (3/180) that a diagnosis of TIA was unlikely. The quality of documentation was fair.Paper II: AF was present in 19% (2779/14980) of patients with TIA compared to 30% (13258/44173) in those with IS. Proportions of AF increased markedly with age. At discharge, 64% (1778/2771) of patients with TIA and AF and 50% (5502/10899) of patients with IS and AF were treated with OACs.Paper III: Patients with TIA and a history of stroke were older, more likely to be male, and they had higher proportions of AF, hypertension, and diabetes mellitus than those without a history of stroke. In TIA patients with prior stroke aged ≥85 years, AF was present in 41% (300/724) compared to 30% (604/2028) in those without prior stroke. At discharge, levels of OAC treatment in TIA patients with AF and prior stroke were lower than in those without prior stroke.Paper IV: Carotid imaging was performed in 70% (10545/15023) of patients with TIA. Determinants for its non-use were age ≥85 years, age 74-84 years, female sex, AF, a history of stroke, and care at a non-university hospital. There were substantial regional variations regarding proportions of carotid imaging, especially in the very elderly.Conclusions: There was interobserver agreement on TIA diagnoses in a majority of cases. More systematic documentation aided by a guide or checklist might improve diagnostic certainty. Data registered in Riksstroke-TIA was valid and suited for scientific evaluation. AF was a common but insufficiently treated risk factor in TIA. Certain patient groups appeared neglected with regard to carotid imaging and secondary…

Subjects/Keywords: Medical and Health Sciences; transient ischemic attack; Ischemic stroke; Register research; Atrial fibrillation; Secondary prevention

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Buchwald, F. (2018). TIA in the Swedish Stroke Register (Riksstroke). Aspects on diagnostic validation, risk factors, investigations, and therapies. (Doctoral Dissertation). University of Lund. Retrieved from https://lup.lub.lu.se/record/ffa6e154-2aa2-4574-bdf4-4dccc06e732e ; https://portal.research.lu.se/ws/files/39306259/kappan_mediatryck_2010205.pdf

Chicago Manual of Style (16^th Edition):

Buchwald, Fredrik. “TIA in the Swedish Stroke Register (Riksstroke). Aspects on diagnostic validation, risk factors, investigations, and therapies.” 2018. Doctoral Dissertation, University of Lund. Accessed January 19, 2021. https://lup.lub.lu.se/record/ffa6e154-2aa2-4574-bdf4-4dccc06e732e ; https://portal.research.lu.se/ws/files/39306259/kappan_mediatryck_2010205.pdf.

MLA Handbook (7^th Edition):

Buchwald, Fredrik. “TIA in the Swedish Stroke Register (Riksstroke). Aspects on diagnostic validation, risk factors, investigations, and therapies.” 2018. Web. 19 Jan 2021.

Vancouver:

Buchwald F. TIA in the Swedish Stroke Register (Riksstroke). Aspects on diagnostic validation, risk factors, investigations, and therapies. [Internet] [Doctoral dissertation]. University of Lund; 2018. [cited 2021 Jan 19]. Available from: https://lup.lub.lu.se/record/ffa6e154-2aa2-4574-bdf4-4dccc06e732e ; https://portal.research.lu.se/ws/files/39306259/kappan_mediatryck_2010205.pdf.

Council of Science Editors:

Buchwald F. TIA in the Swedish Stroke Register (Riksstroke). Aspects on diagnostic validation, risk factors, investigations, and therapies. [Doctoral Dissertation]. University of Lund; 2018. Available from: https://lup.lub.lu.se/record/ffa6e154-2aa2-4574-bdf4-4dccc06e732e ; https://portal.research.lu.se/ws/files/39306259/kappan_mediatryck_2010205.pdf

Universidade Federal de Santa Maria

28. Maísa de Carvalho Corrêa. AVALIAÇÃO DE INDICADORES DO ESTRESSE OXIDATIVO E DA ATIVIDADE DA ENZIMA ACETILCOLINESTERASE SANGÜÍNEA EM PACIENTES COM DIAGNÓSTICO DE ACIDENTE VASCULAR CEREBRAL ISQUÊMICO.

Degree: 2006, Universidade Federal de Santa Maria

URL: http://coralx.ufsm.br/tede/tde_busca/arquivo.php?codArquivo=421

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No acidente vascular isquêmico, o dano ao encéfalo é causado por uma redução ou um bloqueio completo do fluxo sangüíneo resultando em liberação deficiente de… (more)

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No acidente vascular isquêmico, o dano ao encéfalo é causado por uma redução ou um bloqueio completo do fluxo sangüíneo resultando em liberação deficiente de glicose e oxigênio. É uma das principais causas de mortalidade e incapacitação entre os idosos. Em sua maioria não são fatais e os sobreviventes têm alto risco de complicações vasculares subseqüentes. A hipertensão é o mais importante fator de risco para o acidente vascular cerebral, presente em 70% de todos os casos. Acredita-se que o estresse oxidativo é um dos mecanismos associados ao dano neuronal após o evento isquêmico. O papel chave que o sistema colinérgico desempenha nas funções normais do encéfalo e distúrbios de memória de vários processos patológicos assim como no controle do fluxo sanguíneo cerebral vem sendo bem documentado. Este trabalho investigou o perfil oxidativo e a atividade da enzima acetilcolinesterase sangüínea em pacientes com diagnóstico de acidente vascular cerebral isquêmico, na fase aguda e crônica assim como a influência da hipertensão em tal patologia. Determinou-se a atividade da catalase em sangue total, os níveis de glutationa reduzida em eritrócitos, TBARS e o conteúdo de proteína carbonil em amostras de soro da população estudada. O perfil oxidativo de lipídeos e proteínas, representado pelos níveis de MDA e conteúdo de proteína carbonil mostrou-se aumentado na fase aguda do evento isquêmico e no grupo hipertenso quando comparado com o controle. A atividade da catalase e os níveis de glutationa reduzida nos pacientes pertencentes ao estágio agudo encontraram-se aumentadas em relação aos grupos hipertenso e controle. Nenhuma diferença na atividade da catalase foi encontrada entre pacientes do estágio crônico da isquemia carebral e aqueles do grupo hipertenso (p<0,05). A atividade da AChE sangüínea durante a fase aguda do acidente vascular isquêmico foi aumentada em relação àquela apresentada pelos grupos controle, hipertenso e crônico (p<0,05). Também, nenhuma diferença foi observada entre o grupo crônico e o controle. O grupo hipertenso apresentou atividade da AChE significativamente menor que os outros grupos. Os resultados sugerem que o aumento da defesa antioxidante age como um mecanismo compensatório como consequência da superprodução de espécies reativas de oxigênio (EROs) após o evento isquêmico agudo. Este estudo também demonstrou que a hipertensão atua como um fator de risco prevalente para o acidente vascular isquêmico, contribuindo para o dano oxidativo celular. Os resultados também revelaram que a isquemia exerce efeito modulador na atividade da AChE em eritrócitos, a fim de manter adequados níveis do neurotransmissor acetilcolina (ACh) em resposta as diferentes fases da injúria neurológica causada pela isquemia. Conclui-se então que o evento isquêmico, apesar de ter localização definida, resulta em uma desordem sistêmica, induzindo mudanças, as quais podem ser detectadas pela medida de marcadores periféricos do estresse oxidativo e atividade da AChE sangüínea.

In ischemic stroke, damage to the brain is caused by…

Advisors/Committee Members: Maria Rosa Chitolina Schetinger, Maria Ester Pereira, Carlos Alexandre Netto, Cleci Menezes Moreira.

Subjects/Keywords: acidente vascular isquêmico; estresse oxidativo; AVCi agudo; AVCi crônico; acetilcolinesterase; BIOQUIMICA; ischemic stroke; oxidative stress; acute ischemic stroke; chronic ischemic stroke; acetylcholinesterase

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Corrêa, M. d. C. (2006). AVALIAÇÃO DE INDICADORES DO ESTRESSE OXIDATIVO E DA ATIVIDADE DA ENZIMA ACETILCOLINESTERASE SANGÜÍNEA EM PACIENTES COM DIAGNÓSTICO DE ACIDENTE VASCULAR CEREBRAL ISQUÊMICO. (Thesis). Universidade Federal de Santa Maria. Retrieved from http://coralx.ufsm.br/tede/tde_busca/arquivo.php?codArquivo=421

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Corrêa, Maísa de Carvalho. “AVALIAÇÃO DE INDICADORES DO ESTRESSE OXIDATIVO E DA ATIVIDADE DA ENZIMA ACETILCOLINESTERASE SANGÜÍNEA EM PACIENTES COM DIAGNÓSTICO DE ACIDENTE VASCULAR CEREBRAL ISQUÊMICO.” 2006. Thesis, Universidade Federal de Santa Maria. Accessed January 19, 2021. http://coralx.ufsm.br/tede/tde_busca/arquivo.php?codArquivo=421.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Corrêa, Maísa de Carvalho. “AVALIAÇÃO DE INDICADORES DO ESTRESSE OXIDATIVO E DA ATIVIDADE DA ENZIMA ACETILCOLINESTERASE SANGÜÍNEA EM PACIENTES COM DIAGNÓSTICO DE ACIDENTE VASCULAR CEREBRAL ISQUÊMICO.” 2006. Web. 19 Jan 2021.

Vancouver:

Corrêa MdC. AVALIAÇÃO DE INDICADORES DO ESTRESSE OXIDATIVO E DA ATIVIDADE DA ENZIMA ACETILCOLINESTERASE SANGÜÍNEA EM PACIENTES COM DIAGNÓSTICO DE ACIDENTE VASCULAR CEREBRAL ISQUÊMICO. [Internet] [Thesis]. Universidade Federal de Santa Maria; 2006. [cited 2021 Jan 19]. Available from: http://coralx.ufsm.br/tede/tde_busca/arquivo.php?codArquivo=421.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Corrêa MdC. AVALIAÇÃO DE INDICADORES DO ESTRESSE OXIDATIVO E DA ATIVIDADE DA ENZIMA ACETILCOLINESTERASE SANGÜÍNEA EM PACIENTES COM DIAGNÓSTICO DE ACIDENTE VASCULAR CEREBRAL ISQUÊMICO. [Thesis]. Universidade Federal de Santa Maria; 2006. Available from: http://coralx.ufsm.br/tede/tde_busca/arquivo.php?codArquivo=421

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Newcastle

29. Tian, Huiqiao. Multimodal computed tomography in patient selection for acute ischemic stroke intervention.

Degree: PhD, 2019, University of Newcastle

URL: http://hdl.handle.net/1959.13/1408713

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Research Doctorate - Doctor of Philosophy (PhD)

Background: Multimodal computed tomographic (CT) imaging for acute ischemic stroke patients being considered for therapy has been the… (more)

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Research Doctorate - Doctor of Philosophy (PhD)

Background: Multimodal computed tomographic (CT) imaging for acute ischemic stroke patients being considered for therapy has been the focus of an increasing body of research over the past decade. The impact of this research has been an increasing use of multimodal CT for individual patient management in acute ischemic stroke by, for example, by excluding hemorrhages from therapy, assisting the treatment decision making process for neurologists or providing useful information to prediction patient outcomes and inform patient family discussions. However, numerous important research questions remain unanswered in this field. The body of work presented in this thesis attempts to answer a number of clinical questions in the application of multimodal CT imaging in acute stroke. Computed tomography (CT), including non-contrast CT (NCCT), CT perfusion (CTP), and CT angiography (CTA) is being increasingly applied in acute stroke imaging because its wide availability, safety and ability to be performed rapidly as an imaging technique when compared to conventional magnetic resonance imaging (MRI). Furthermore, the endovascular trials published in 2015 have shown that multimodal CT selection of patients with M1-segment of the middle cerebral artery, or internal carotid artery occlusions who undergo thrombectomy therapy have significantly better clinical outcomes compared to the best medical care intravenous thrombolysis. Additionally, the recent positive endovascular stroke trials extending the treatment time window from 6 to 24 hours required to use of multimodal CT including CTP imaging to identify patients with reperfusion-responsive lesions. As a result, the utility of CTP imaging and the angiographic modalities, including static CTA, multiphase CTA, and dynamic CTA have become more important for the evaluation of the cerebral vasculature. This thesis aimed to 1) assess the ‘treatment effect’ of alteplase in patients without a baseline vessel occlusion (Chapter IV); 2a) test the vessel occlusion location frequency and clinical and perfusion imaging profiles of patients presenting with differing occlusion locations; 2b) understand if occlusion location was an independent predictor of outcome; 2c) test the relationship between occlusion location and baseline ischemic core, a known predictor of modified Rankin Scale (mRS) at 90-day; 2d) assess the influences of excluding patients with a proximal large vessel occlusion from thrombolysis trials on the power of the study (Chapter V); 3a) test the inter-rater reliability of collateral scores assessed on dynamic CTA and optimized multiphase CTA; 3b) test the relationships of collaterals assessed on dynamic CTA and multiphase CTA with CTP tissue compartments (Chapter VI). Methods: Acute ischemic stroke patients included in this thesis were sourced from the INternational Stroke Perfusion Imaging REgistry (INSPIRE). All included patients underwent multimodal CT imaging before treatment. The baseline and follow-up CTP images were…

Advisors/Committee Members: University of Newcastle. Faculty of Health & Medicine, School of Medicine and Public Health.

Subjects/Keywords: acute ischemic stroke; ischemic stroke patients; thrombolysis; computed tomographic perfusion; computed tomographic angiography; ischemic stroke intervention; multimodal computed tomography; thesis by publication

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Tian, H. (2019). Multimodal computed tomography in patient selection for acute ischemic stroke intervention. (Doctoral Dissertation). University of Newcastle. Retrieved from http://hdl.handle.net/1959.13/1408713

Chicago Manual of Style (16^th Edition):

Tian, Huiqiao. “Multimodal computed tomography in patient selection for acute ischemic stroke intervention.” 2019. Doctoral Dissertation, University of Newcastle. Accessed January 19, 2021. http://hdl.handle.net/1959.13/1408713.

MLA Handbook (7^th Edition):

Tian, Huiqiao. “Multimodal computed tomography in patient selection for acute ischemic stroke intervention.” 2019. Web. 19 Jan 2021.

Vancouver:

Tian H. Multimodal computed tomography in patient selection for acute ischemic stroke intervention. [Internet] [Doctoral dissertation]. University of Newcastle; 2019. [cited 2021 Jan 19]. Available from: http://hdl.handle.net/1959.13/1408713.

Council of Science Editors:

Tian H. Multimodal computed tomography in patient selection for acute ischemic stroke intervention. [Doctoral Dissertation]. University of Newcastle; 2019. Available from: http://hdl.handle.net/1959.13/1408713

University of Gothenburg / Göteborgs Universitet

30. Hanson, Ellen. The hemostatic pathway in ischemic stroke. Clinical studies of genetic variation and plasma protein measurements.

Degree: 2012, University of Gothenburg / Göteborgs Universitet

URL: http://hdl.handle.net/2077/29210

► Although stroke is a common cause of death and disability in adults, there are few studies on stroke compared to other common diseases. A stroke… (more)

Subjects/Keywords: ischemic stroke; etiologic subtypes of ischemic stroke; genetics; SNP; hemostasis; prothrombotic; ADAMTS13; VWF; ABO blood group; FSAP; FXI

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Hanson, E. (2012). The hemostatic pathway in ischemic stroke. Clinical studies of genetic variation and plasma protein measurements. (Thesis). University of Gothenburg / Göteborgs Universitet. Retrieved from http://hdl.handle.net/2077/29210

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Hanson, Ellen. “The hemostatic pathway in ischemic stroke. Clinical studies of genetic variation and plasma protein measurements.” 2012. Thesis, University of Gothenburg / Göteborgs Universitet. Accessed January 19, 2021. http://hdl.handle.net/2077/29210.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Hanson, Ellen. “The hemostatic pathway in ischemic stroke. Clinical studies of genetic variation and plasma protein measurements.” 2012. Web. 19 Jan 2021.

Vancouver:

Hanson E. The hemostatic pathway in ischemic stroke. Clinical studies of genetic variation and plasma protein measurements. [Internet] [Thesis]. University of Gothenburg / Göteborgs Universitet; 2012. [cited 2021 Jan 19]. Available from: http://hdl.handle.net/2077/29210.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Hanson E. The hemostatic pathway in ischemic stroke. Clinical studies of genetic variation and plasma protein measurements. [Thesis]. University of Gothenburg / Göteborgs Universitet; 2012. Available from: http://hdl.handle.net/2077/29210

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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Open Access Theses and Dissertations