subject:(Intrinsic transition)

Delft University of Technology

1. van Terwisga, Eline (author). Intrinsic transitions: A strategy for housing corporations to facilitate sustainability in neigbhorhoods.

Degree: 2019, Delft University of Technology

URL: http://resolver.tudelft.nl/uuid:87a2445d-64ca-4ba1-8923-a5a9940f7175

► This graduation project investigates the stimulation of sustainable behaviour among residents from a housing corporation in Eindhoven, Wooninc., and proposes a program for grassroots infrastructure… (more)

▼ This graduation project investigates the stimulation of sustainable behaviour among residents from a housing corporation in Eindhoven, Wooninc., and proposes a program for grassroots infrastructure as a way to support sustainable transitions in neighborhoods.As a partner of the “Duurzaamheidspact Eindhoven” housing corporation Wooninc. formulated the ambition to be more sustainable (Theeuwen, 2018). In order to do so, they not only want to improve their core business but also wants to engage their residents with a more sustainable lifestyle. They adopted the method of ‘De Verborgen Impact’ which includes a train-the-trainer process that trains leading residents, so-called peers, to motivate their fellow residents for a (more) sustainable lifestyle. This led to the key objective for this project: “Design a fitting intervention that peers can use to motivate residents of Wooninc., so that they feel activated to make their lifestyles (more) sustainable.”ApproachBy exploring the design brief and using the designers’ Personal Principles for Good Design the Transition Design method was chosen as the main driver for this design process to understand the project within a broader system context. In addition, the 1:10:100 scheduling technique was applied to allow rapid iterations and to create a concept that is successful and supported by each of the stakeholders. Research & findingsBy conducting four iterative cycles insight in behavioural change was gained from literature and interviews. This resulted in insight in how to reverse internal and external barriers into levers that can be used to support residents in the transition towards a more sustainable lifestyle. This led to the development of the ‘Sustainable Transition’- framework. Which incorporates relevant theories found in literature and maps seven leverage points to inspire for transition towards sustainable behaviour. Based on this framework concept development happened iterative from preliminary vision to the final concept of ‘Onze Verborgen Impact’ Transition Program and Transition Toolkit. The ‘Sustainable Transition’ - framework indicates that to engage residents, as well as peers on their intrinsic motivation all the dimensions of a personal transition should be supported including: motivation and ability, personal values and their position in the process of change. Based on this framework a vision for the final concept was developed: “Making sustainability transparent and accessible (lower the external barriers) by emphasizing the positive side and the advantages of sustainable behaviour (reversing internal barriers). To show that sustainability, in different ways, is accessible for everyone.” The ‘Onze Verborgen Impact’ Transition ProgramTesting prototypes with peers and residents, showed that this concept should not predefine how the peers encounter their fellow residents in their neighborhoods but should enable peers to create their personal approach. This led to the final concept, a transition program called ‘Onze Verborgen Impact’. This program exists… Advisors/Committee Members: Mugge, Ruth (mentor), Baha, Ehsan (graduation committee), Delft University of Technology (degree granting institution).

Subjects/Keywords: Intrinsic transition; Sustainability; Behaviour change

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APA (6^th Edition):

van Terwisga, E. (. (2019). Intrinsic transitions: A strategy for housing corporations to facilitate sustainability in neigbhorhoods. (Masters Thesis). Delft University of Technology. Retrieved from http://resolver.tudelft.nl/uuid:87a2445d-64ca-4ba1-8923-a5a9940f7175

Chicago Manual of Style (16^th Edition):

van Terwisga, Eline (author). “Intrinsic transitions: A strategy for housing corporations to facilitate sustainability in neigbhorhoods.” 2019. Masters Thesis, Delft University of Technology. Accessed March 03, 2021. http://resolver.tudelft.nl/uuid:87a2445d-64ca-4ba1-8923-a5a9940f7175.

MLA Handbook (7^th Edition):

van Terwisga, Eline (author). “Intrinsic transitions: A strategy for housing corporations to facilitate sustainability in neigbhorhoods.” 2019. Web. 03 Mar 2021.

Vancouver:

van Terwisga E(. Intrinsic transitions: A strategy for housing corporations to facilitate sustainability in neigbhorhoods. [Internet] [Masters thesis]. Delft University of Technology; 2019. [cited 2021 Mar 03]. Available from: http://resolver.tudelft.nl/uuid:87a2445d-64ca-4ba1-8923-a5a9940f7175.

Council of Science Editors:

van Terwisga E(. Intrinsic transitions: A strategy for housing corporations to facilitate sustainability in neigbhorhoods. [Masters Thesis]. Delft University of Technology; 2019. Available from: http://resolver.tudelft.nl/uuid:87a2445d-64ca-4ba1-8923-a5a9940f7175

University of Colorado

2. Nummy, Thomas J. Polarization Dependent Angle Resolved Photoemission Spectroscopy for the Determination of Intrinsic Material Symmetries.

Degree: PhD, 2018, University of Colorado

URL: https://scholar.colorado.edu/phys_gradetds/244

► In this thesis I investigate the utility of the polarization and angle dependence of the photoemission matrix element in angle resolved photoemission spectroscopy (ARPES).… (more)

Subjects/Keywords: polarization; angle resolved photoemission spectrosopy; topological phase transition; intrinsic material symmetries; electronic wave function; Materials Science and Engineering; Physics

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APA (6^th Edition):

Nummy, T. J. (2018). Polarization Dependent Angle Resolved Photoemission Spectroscopy for the Determination of Intrinsic Material Symmetries. (Doctoral Dissertation). University of Colorado. Retrieved from https://scholar.colorado.edu/phys_gradetds/244

Chicago Manual of Style (16^th Edition):

Nummy, Thomas J. “Polarization Dependent Angle Resolved Photoemission Spectroscopy for the Determination of Intrinsic Material Symmetries.” 2018. Doctoral Dissertation, University of Colorado. Accessed March 03, 2021. https://scholar.colorado.edu/phys_gradetds/244.

MLA Handbook (7^th Edition):

Nummy, Thomas J. “Polarization Dependent Angle Resolved Photoemission Spectroscopy for the Determination of Intrinsic Material Symmetries.” 2018. Web. 03 Mar 2021.

Vancouver:

Nummy TJ. Polarization Dependent Angle Resolved Photoemission Spectroscopy for the Determination of Intrinsic Material Symmetries. [Internet] [Doctoral dissertation]. University of Colorado; 2018. [cited 2021 Mar 03]. Available from: https://scholar.colorado.edu/phys_gradetds/244.

Council of Science Editors:

Nummy TJ. Polarization Dependent Angle Resolved Photoemission Spectroscopy for the Determination of Intrinsic Material Symmetries. [Doctoral Dissertation]. University of Colorado; 2018. Available from: https://scholar.colorado.edu/phys_gradetds/244

University of Western Ontario

3. Feeney, Mistianne. Create the Scene and Watch the Show Unfold: Following Vegetative to Embryonic Developmental Transitions by Over-Expressing LEC2 in Leaves of Arabidopsis thaliana.

Degree: 2012, University of Western Ontario

URL: https://ir.lib.uwo.ca/etd/600

► During seed development, the lytic vacuole (LV) is replaced by a protein storage vacuole (PSV) which specializes in accumulating seed storage proteins (SSPs). As seed… (more)

▼ During seed development, the lytic vacuole (LV) is replaced by a protein storage vacuole (PSV) which specializes in accumulating seed storage proteins (SSPs). As seed protein reserves are mobilized upon germination, the PSV is once again replaced by the LV which takes on different roles in vegetative tissues. Cellular events occurring during these developmental transitions are not well understood, particularly, the transition between vacuole types. This research investigates whether PSVs can exist in leaves. To study vacuole transitions in leaves, an Arabidopsis thaliana line over-expressing the LEAFY COTYLEDON2 (LEC2) transcription factor was used. LEC2 is a master regulator of embryogenesis responsible for creating a cellular environment that promotes embryogenic development. Over-expression of LEC2 causes vegetative tissues to change their developmental fate to an embryonic state. LEC2 alters the leaf phenotype at the subcellular level; chloroplasts de-differentiated and contained more starch. The cytoplasm becomes filled with oil bodies, which are typically seed organelles. The large LV was replaced by small-sized vacuoles that accumulated protein deposits. Since LEC2 is responsible for activating the synthesis of SSPs during seed development, SSP accumulation was investigated in leaves. The major Arabidopsis SSP families were shown to accumulate within small sized vacuoles in leaf cells. By exploiting the developmental and tissue specific localization of two tonoplast intrinsic protein (TIP) isoforms, the small vacuoles were identified as PSVs. A time course following the cellular alterations and accumulation of seed proteins in leaves after induction of LEC2 activity with dexamethasone (DEX) revealed the appearance of embryonic characteristics as early as 4 days on DEX and became more prominent over time. Additionally, a dynamic view of the transition between vacuole types was observed using TIP isoforms fused to fluorescent markers. The morphology of leaf vacuoles was altered to resemble an amalgamation of a LV and PSV. Results suggest that as the LV transitions to a PSV, the tonoplast remodels before the large vacuole is replaced by smaller PSVs. The formation of PSVs in leaves in response to LEC2 over-expression is a novel approach to study vacuoles and will lead to a better understanding of their basic biology.

Subjects/Keywords: Arabidopsis thaliana; protein storage vacuole; LEC2; leaf; seed storage protein; tonoplast intrinsic protein; developmental transition; chloroplast; oil body; Cell Biology

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APA (6^th Edition):

Feeney, M. (2012). Create the Scene and Watch the Show Unfold: Following Vegetative to Embryonic Developmental Transitions by Over-Expressing LEC2 in Leaves of Arabidopsis thaliana. (Thesis). University of Western Ontario. Retrieved from https://ir.lib.uwo.ca/etd/600

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Feeney, Mistianne. “Create the Scene and Watch the Show Unfold: Following Vegetative to Embryonic Developmental Transitions by Over-Expressing LEC2 in Leaves of Arabidopsis thaliana.” 2012. Thesis, University of Western Ontario. Accessed March 03, 2021. https://ir.lib.uwo.ca/etd/600.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Feeney, Mistianne. “Create the Scene and Watch the Show Unfold: Following Vegetative to Embryonic Developmental Transitions by Over-Expressing LEC2 in Leaves of Arabidopsis thaliana.” 2012. Web. 03 Mar 2021.

Vancouver:

Feeney M. Create the Scene and Watch the Show Unfold: Following Vegetative to Embryonic Developmental Transitions by Over-Expressing LEC2 in Leaves of Arabidopsis thaliana. [Internet] [Thesis]. University of Western Ontario; 2012. [cited 2021 Mar 03]. Available from: https://ir.lib.uwo.ca/etd/600.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Feeney M. Create the Scene and Watch the Show Unfold: Following Vegetative to Embryonic Developmental Transitions by Over-Expressing LEC2 in Leaves of Arabidopsis thaliana. [Thesis]. University of Western Ontario; 2012. Available from: https://ir.lib.uwo.ca/etd/600

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Liberty University

4. Stephens, Joan. Student Transition into Kindergarten: A Case Study of the Reggio Emilia Approach.

Degree: 2018, Liberty University

URL: http://digitalcommons.liberty.edu/doctoral/1735

► The purpose of this intrinsic case study was to arrive at a better understanding of what teachers contribute to the unique issues of student transition… (more)

Subjects/Keywords: Early Childhood Education; Intrinsic; Reggio Emilia Approach; Social Constructivist Theory; Transition; Education; Educational Assessment, Evaluation, and Research; Educational Methods; Educational Psychology; Other Education

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Stephens, J. (2018). Student Transition into Kindergarten: A Case Study of the Reggio Emilia Approach. (Doctoral Dissertation). Liberty University. Retrieved from http://digitalcommons.liberty.edu/doctoral/1735

Chicago Manual of Style (16^th Edition):

Stephens, Joan. “Student Transition into Kindergarten: A Case Study of the Reggio Emilia Approach.” 2018. Doctoral Dissertation, Liberty University. Accessed March 03, 2021. http://digitalcommons.liberty.edu/doctoral/1735.

MLA Handbook (7^th Edition):

Stephens, Joan. “Student Transition into Kindergarten: A Case Study of the Reggio Emilia Approach.” 2018. Web. 03 Mar 2021.

Vancouver:

Stephens J. Student Transition into Kindergarten: A Case Study of the Reggio Emilia Approach. [Internet] [Doctoral dissertation]. Liberty University; 2018. [cited 2021 Mar 03]. Available from: http://digitalcommons.liberty.edu/doctoral/1735.

Council of Science Editors:

Stephens J. Student Transition into Kindergarten: A Case Study of the Reggio Emilia Approach. [Doctoral Dissertation]. Liberty University; 2018. Available from: http://digitalcommons.liberty.edu/doctoral/1735

University of South Florida

5. Powell, Chase David. Role of Heat Shock Transcription Factor 1 in Ovarian Cancer Epithelial-Mesenchymal Transition and Drug Sensitivity.

Degree: 2017, University of South Florida

URL: https://scholarcommons.usf.edu/etd/7079

► The heat shock response (HSR) is a robust cellular reaction to mitigate protein damage from heat and other challenges to the proteome. This protective molecular… (more)

▼ The heat shock response (HSR) is a robust cellular reaction to mitigate protein damage from heat and other challenges to the proteome. This protective molecular program in humans is controlled by heat shock transcription factor 1 (HSF1). Activation of HSF1 leads to the induction of an array of cytoprotective genes, many of which code for chaperones. These chaperones, known as heat shock proteins (HSPs), are responsible for maintaining the functional integrity of the proteome. HSPs achieve this by promoting proper folding and assembly of nascent proteins, refolding denatured proteins, and processing for degradation proteins and aggregates which cannot be returned to a functional conformation. The powerful ability of the heat shock response to promote cell survival makes its master regulator, HSF1, an important point of research. To garner a better understanding of HSF1, we reviewed the role of the highly dynamic HSF1 protein structure and investigated how HSF1 affects cancer cell behavior and drug response. Cancers can be characterized in part by abhorrent replication, self-sufficient growth signaling, invasion, and evasion of apoptosis. HSF1 has been found to promote proliferation, invasion, and drug resistance in several types of cancer; including lung and ovarian cancer. Ovarian cancer has elevated levels of HSF1, but the role of HSF1 in ovarian cancer behavior had not been previously examined. Researching the role of HSF1 in ovarian cancer is merited, because treatment outcomes are poor due to the high frequency of late stage detection and drug resistance. We hypothesized that HSF1 is important in the malignant growth and drug resistance of ovarian cancer. We have created ovarian cancer cell lines with inducible knockdown of HSF1 to investigate how HSF1 contributes to the behavior of ovarian cancer. This allowed us to examine the behavior of cells in the absence HSF1. Both 2D and 3D spheroid tissue culture models were used to study how HSF1 contributes to the growth and invasion of ovarian cancer cells after treatment with the transforming growth factor β (TGFβ) cytokine. Additionally, we studied how HSF1 reduction modulates the response to multiple therapeutic drugs. Our research shows that HSF1 induces epithelial-mesenchymal transition (EMT) in a 3D growth model. Our work also demonstrates that reduction of HSF1 sensitizes ovarian cancer cells to multiple drugs.

Subjects/Keywords: Heat Shock Factor 1; Ovarian Cancer; Epithelial to Mesenchymal Transition; Transforming Growth Factor β; HSP90 Inhibitors; Spheroid Culture; intrinsic disorder; Cell Biology; Molecular Biology; Oncology

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APA (6^th Edition):

Powell, C. D. (2017). Role of Heat Shock Transcription Factor 1 in Ovarian Cancer Epithelial-Mesenchymal Transition and Drug Sensitivity. (Thesis). University of South Florida. Retrieved from https://scholarcommons.usf.edu/etd/7079

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Powell, Chase David. “Role of Heat Shock Transcription Factor 1 in Ovarian Cancer Epithelial-Mesenchymal Transition and Drug Sensitivity.” 2017. Thesis, University of South Florida. Accessed March 03, 2021. https://scholarcommons.usf.edu/etd/7079.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Powell, Chase David. “Role of Heat Shock Transcription Factor 1 in Ovarian Cancer Epithelial-Mesenchymal Transition and Drug Sensitivity.” 2017. Web. 03 Mar 2021.

Vancouver:

Powell CD. Role of Heat Shock Transcription Factor 1 in Ovarian Cancer Epithelial-Mesenchymal Transition and Drug Sensitivity. [Internet] [Thesis]. University of South Florida; 2017. [cited 2021 Mar 03]. Available from: https://scholarcommons.usf.edu/etd/7079.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Powell CD. Role of Heat Shock Transcription Factor 1 in Ovarian Cancer Epithelial-Mesenchymal Transition and Drug Sensitivity. [Thesis]. University of South Florida; 2017. Available from: https://scholarcommons.usf.edu/etd/7079

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

6. Van Den Berg, Tineke. Conductivité de spin et effets magnétiques dans les systèmes quantiques désordonnés : Spin conductivity and magnetic effects in disordered quantum systems.

Degree: Docteur es, Sciences des Matériaux, Physique, Chimie et Nanosciences, 2012, Aix Marseille Université

URL: http://www.theses.fr/2012AIXM4812

►

Dans une première partie nous explorerons les effets d'impuretés désordonnées et paramagnétiques sur l'effet spin-Hall intrinsèque dans un gaz d'électrons bi-dimensionnel avec un couplage spin-orbite… (more)

▼

Dans une première partie nous explorerons les effets d'impuretés désordonnées et paramagnétiques sur l'effet spin-Hall intrinsèque dans un gaz d'électrons bi-dimensionnel avec un couplage spin-orbite de Rashba. A faible désordre, la conductivité de spin-Hall reste proche de sa valeur d'échantillon pur, comme le montrent un calcul analytique de réponse linéaire et une étude numérique. De fortes fluctuations sont toutefois observées, elles augmentent avec l'importance du désordre. Pour caractériser la dynamique d'un paquet d'onde sur un réseau, nous mesurons sa taille, le taux de participation inverse, et sa dimension de corrélation. Le système subit une transition de localisation à une valeur critique du désordre. Dans le régime localisé, la densité locale d'états n'est plus uniforme et ne coïncide plus avec la densité totale d'états. Une corrélation antiferromagnétique entre les impuretés et les électrons de conduction est observée. Après la transition de localisation, la conductivité de spin augmente significativement. La première correction quantique dans le formalisme de réponse linéaire, contribue positivement à la conductivité de spin-Hall. Dans une seconde partie, le modèle de Hubbard avec double échange avec corrélations électroniques est étudié par la méthode du champ moyen dynamique (DMFT) dans l'approximation de non-croisement pour la résolution du problème d'impureté (NCA). Autour du quart remplissage, un polaron orbital est observé et décrit à l'aide d'un Hamiltonien effectif. Le double échange dans les semi-conducteurs magnétiques dilués est étudié dans l'approximation du potentiel cohérent (CPA).

Spintronics is a research area that is concerned with the storage and transfer of information by means of electron spins. In the first part we investigated the intrinsic spin Hall effect in the presence of disordered magnetic impurities in a paramagnetic state in a two dimensional electron gas with Rashba spin-orbit coupling. In the presence of weak magnetic disorder the spin Hall conductivity stays close to its universal (clean system) value, as shown by analytical linear response calculations and numerical simulations. Heavy spin conductivity fluctuations are observed, that increase with disorder strength. To investigate the spreading of a wavepacket on a lattice we measure the wavepacket width, the inverse participation ratio and the (2)-fractal dimension. It is shown the system undergoes a localization transition at a critical disorder strength. In the localized regime the local density of states is not uniform anymore. An anti-ferromagnetic correlation between electron spins and impurity magnetic moments is observed. Beyond the localization transition the spin conductivity increases significantly. The first quantum (Cooperon) corrections in the linear response formalism are shown to contribute positively to the spin Hall conductivity. In the second part the double exchange Hubbard model for correlated electron systems is studied using dynamical mean field theory (DMFT) with the non-crossing…

Advisors/Committee Members: Verga, Alberto (thesis director).

Subjects/Keywords: Effet Hall de spin intrinsèque; Conductivité de spin; Couplage spin-orbite; Désordre magnétique; Transition de localisation; Densité locale d'état; Intrinsic spin Hall effect; Spin conductivity; Spin orbit coupling; Magnetic disorder; Localization transition; Local density of states

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APA (6^th Edition):

Van Den Berg, T. (2012). Conductivité de spin et effets magnétiques dans les systèmes quantiques désordonnés : Spin conductivity and magnetic effects in disordered quantum systems. (Doctoral Dissertation). Aix Marseille Université. Retrieved from http://www.theses.fr/2012AIXM4812

Chicago Manual of Style (16^th Edition):

Van Den Berg, Tineke. “Conductivité de spin et effets magnétiques dans les systèmes quantiques désordonnés : Spin conductivity and magnetic effects in disordered quantum systems.” 2012. Doctoral Dissertation, Aix Marseille Université. Accessed March 03, 2021. http://www.theses.fr/2012AIXM4812.

MLA Handbook (7^th Edition):

Van Den Berg, Tineke. “Conductivité de spin et effets magnétiques dans les systèmes quantiques désordonnés : Spin conductivity and magnetic effects in disordered quantum systems.” 2012. Web. 03 Mar 2021.

Vancouver:

Van Den Berg T. Conductivité de spin et effets magnétiques dans les systèmes quantiques désordonnés : Spin conductivity and magnetic effects in disordered quantum systems. [Internet] [Doctoral dissertation]. Aix Marseille Université 2012. [cited 2021 Mar 03]. Available from: http://www.theses.fr/2012AIXM4812.

Council of Science Editors:

Van Den Berg T. Conductivité de spin et effets magnétiques dans les systèmes quantiques désordonnés : Spin conductivity and magnetic effects in disordered quantum systems. [Doctoral Dissertation]. Aix Marseille Université 2012. Available from: http://www.theses.fr/2012AIXM4812

University of Georgia

7. Wang, Xiao. High level ab initio characterization of small hydrocarbons and efficient implementation of density cumulant theory.

Degree: 2017, University of Georgia

URL: http://hdl.handle.net/10724/36675

► Accurate characterization of thermochemistry and kinetic properties requires high level ab initio approaches. In this dissertation, we present both ab initio quantum chemical applications and… (more)

Subjects/Keywords: ab initio quantum chemistry; electronic structure theory; coupled cluster theory; vibrational perturbation theory; singlet-triplet gap; triplet excited state; ethylene; cyclobutylidene; intrinsic reaction path; reaction rate; focal point analysis; density cumulant functional theory; density fitting; spin adaptation; transition metal complexes

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APA (6^th Edition):

Wang, X. (2017). High level ab initio characterization of small hydrocarbons and efficient implementation of density cumulant theory. (Thesis). University of Georgia. Retrieved from http://hdl.handle.net/10724/36675

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Wang, Xiao. “High level ab initio characterization of small hydrocarbons and efficient implementation of density cumulant theory.” 2017. Thesis, University of Georgia. Accessed March 03, 2021. http://hdl.handle.net/10724/36675.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Wang, Xiao. “High level ab initio characterization of small hydrocarbons and efficient implementation of density cumulant theory.” 2017. Web. 03 Mar 2021.

Vancouver:

Wang X. High level ab initio characterization of small hydrocarbons and efficient implementation of density cumulant theory. [Internet] [Thesis]. University of Georgia; 2017. [cited 2021 Mar 03]. Available from: http://hdl.handle.net/10724/36675.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Wang X. High level ab initio characterization of small hydrocarbons and efficient implementation of density cumulant theory. [Thesis]. University of Georgia; 2017. Available from: http://hdl.handle.net/10724/36675

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Illinois – Urbana-Champaign

8. Ganguly, Abir. Computational studies of the structure, dynamics, and catalysis of the hepatitis delta virus ribozyme.

Degree: PhD, 0335, 2014, University of Illinois – Urbana-Champaign

URL: http://hdl.handle.net/2142/50531

► Ribozymes represent a unique class of RNA that is capable of catalyzing biochemical reactions. Since their discovery three decades ago, ribozymes have been shown to… (more)

▼ Ribozymes represent a unique class of RNA that is capable of catalyzing biochemical reactions. Since their discovery three decades ago, ribozymes have been shown to be involved in numerous crucial biological processes, such as gene regulation, translation, and RNA splicing. Similar to protein enzymes, these catalytic RNAs fold into well-defined tertiary structures with organized active sites to carry out catalysis. While their side chains do not possess the variety in functional groups accessible to the side chains of their protein counterparts, their efficiency as biological catalysts is often comparable to protein enzymes, making their catalytic strategies highly interesting. The study of ribozymes is also motivated by their possible significance in evolutionary biology. The hepatitis delta virus (HDV) ribozyme is a small nucleolytic RNA that performs a phosphodiester self-cleavage reaction generating products with a 2’, 3’-cyclic phosphate and a 5’ -hydroxyl termini. This ribozyme was initially discovered in the RNA genome of the human pathogen HDV, where it played a crucial role in the viral life cycle, cleaving site-specifically the multimeric copies of the RNA genome into monomeric pieces. More recently, HDV-like ribozymes have been shown to be widespread across all kingdoms of life. Since their discovery, the HDV ribozymes have been intensely studied from structural as well as mechanistic perspectives, and much is known about their structure and catalytic strategies. The HDV ribozyme has a compact double-pseudoknot structure and uses a combination of metal ion and nucleobase catalysis to effect its self-cleavage reaction. An active site cytosine C75 is thought to act as a general acid in the catalytic reaction by donating a proton to the 5’-hydroxyl of the leaving group, and an active site Mg2+ ion has been purported to play the role of a Lewis acid and activate the O2’ nucleophile. The exact role of this putative catalytic ion is still uncertain. A crystal structure also revealed a rare reverse G•U wobble close to the active site interacting with the putative catalytic ion. This base pair has been hypothesized to play an important role in positioning the metal ion for catalysis. In this dissertation, the HDV ribozyme was studied using a variety of computational approaches. Classical molecular dynamics (MD) simulations and non-linear Poisson-Boltzmann (NLPB) calculations were utilized to study the metal binding characteristics of the reverse G•U wobble close to the active site of the ribozyme. These studies revealed that the reverse wobble creates a highly negative pocket that allows it to interact with metal ions and helps to shift the pKa of the nucleobase C75, thereby facilitating its protonation. MD simulations were also used to investigate the impact of C75 protonation and Mg2+ ion interaction at the reverse G•U wobble on the structure as well as the motions of the HDV ribozyme. The protonated state of C75 was found to be essential for keeping the active site organized for catalysis. A localized,… Advisors/Committee Members: Hammes-Schiffer, Sharon (advisor), Hammes-Schiffer, Sharon (Committee Chair), Gruebele, Martin (committee member), Martinis, Susan A. (committee member), Tajkhorshid, Emad (committee member).

Subjects/Keywords: hepatitis delta virus (HDV) ribozyme; Catalysis; Self-cleavage; Computational studies; Molecular Dynamics; Quantum mechanical/molecular mechanical (QM/MM); Free Energy Simulations; Reaction pathways; Finite temperature string simulations; minimum energy path (MEP); minimum free energy path (MFEP); Transition state; intrinsic reaction coordinate (IRC)

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Ganguly, A. (2014). Computational studies of the structure, dynamics, and catalysis of the hepatitis delta virus ribozyme. (Doctoral Dissertation). University of Illinois – Urbana-Champaign. Retrieved from http://hdl.handle.net/2142/50531

Chicago Manual of Style (16^th Edition):

Ganguly, Abir. “Computational studies of the structure, dynamics, and catalysis of the hepatitis delta virus ribozyme.” 2014. Doctoral Dissertation, University of Illinois – Urbana-Champaign. Accessed March 03, 2021. http://hdl.handle.net/2142/50531.

MLA Handbook (7^th Edition):

Ganguly, Abir. “Computational studies of the structure, dynamics, and catalysis of the hepatitis delta virus ribozyme.” 2014. Web. 03 Mar 2021.

Vancouver:

Ganguly A. Computational studies of the structure, dynamics, and catalysis of the hepatitis delta virus ribozyme. [Internet] [Doctoral dissertation]. University of Illinois – Urbana-Champaign; 2014. [cited 2021 Mar 03]. Available from: http://hdl.handle.net/2142/50531.

Council of Science Editors:

Ganguly A. Computational studies of the structure, dynamics, and catalysis of the hepatitis delta virus ribozyme. [Doctoral Dissertation]. University of Illinois – Urbana-Champaign; 2014. Available from: http://hdl.handle.net/2142/50531

University of British Columbia

9. Sigurbjornsson, Omar Freyr. Vibrational dynamics of icy aerosol particles : phase transitions and intrinsic particle properties.

Degree: MS- MSc, Chemistry, 2008, University of British Columbia

URL: http://hdl.handle.net/2429/2795

► Phase transitions and other intrinsic properties (shape, size, architecture) of molecularly structured aerosol particles are important for understanding their role in planetary atmospheres and for… (more)

Subjects/Keywords: Aerosol spectroscopy; Phase transition kinetics; Intrinsic particle properties; Ethane aerosol; Fluoroform aerosol; Surface versus volume nucleation; Supercooled ethane aerosol; Titan aerosol

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APA (6^th Edition):

Sigurbjornsson, O. F. (2008). Vibrational dynamics of icy aerosol particles : phase transitions and intrinsic particle properties. (Masters Thesis). University of British Columbia. Retrieved from http://hdl.handle.net/2429/2795

Chicago Manual of Style (16^th Edition):

Sigurbjornsson, Omar Freyr. “Vibrational dynamics of icy aerosol particles : phase transitions and intrinsic particle properties.” 2008. Masters Thesis, University of British Columbia. Accessed March 03, 2021. http://hdl.handle.net/2429/2795.

MLA Handbook (7^th Edition):

Sigurbjornsson, Omar Freyr. “Vibrational dynamics of icy aerosol particles : phase transitions and intrinsic particle properties.” 2008. Web. 03 Mar 2021.

Vancouver:

Sigurbjornsson OF. Vibrational dynamics of icy aerosol particles : phase transitions and intrinsic particle properties. [Internet] [Masters thesis]. University of British Columbia; 2008. [cited 2021 Mar 03]. Available from: http://hdl.handle.net/2429/2795.

Council of Science Editors:

Sigurbjornsson OF. Vibrational dynamics of icy aerosol particles : phase transitions and intrinsic particle properties. [Masters Thesis]. University of British Columbia; 2008. Available from: http://hdl.handle.net/2429/2795

University of Southern California

10. Samarawickrame, Sachithra D. Musculotendinous adaptations associated with a functional training program: the transition to barefoot running.

Degree: PhD, Biokinesiology and Physical Therapy, 2017, University of Southern California

URL: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/540475/rec/4295

► The overall goal of this dissertation was to examine the musculotendinous adaptations in the lower leg and foot when habitually shod rearfoot‐striking distance runners transitioned… (more)

▼ The overall goal of this dissertation was to examine the musculotendinous adaptations in the lower leg and foot when habitually shod rearfoot‐striking distance runners transitioned to true barefoot running. To achieve this, four studies were undertaken. The first study was to determine how novice barefoot runners respond to a bout of exertion (a dose of running), compared to the response to the same dose of exertion in the habitual shod condition. There were strong correlations between strike index and the exertion related i) decline in plantarflexor muscle peak torque and ii) peak rate of torque development; as well as with the iii) increased activation of the soleus during the early loading phase of stance. The soleus is preferentially activated during barefoot running, potentially leading to greater long term adaptations. Muscle performance, soleus activation and ankle joint coactivation also demonstrate significant changes in the novel barefoot rearfoot‐strike condition, indicating that being barefoot alone causes changes in neuromuscular control. The purpose of the second study was to quantify plantarflexor musculotendinous unit adaptations to a nine‐week transition to barefoot running in this cohort of shod runners. This prospective study demonstrated increases in plantarflexor muscle torque, as well as increases in pennation angle and volume of the soleus, in runners who adopted a forefoot‐ or midfoot‐strike landing pattern. This is due to the greater relative loading of the soleus during the more flexed knee and more plantarflexed ankle during landing in barefoot running. The training effects of barefoot running are driven by running with a forefoot‐ or midfoot‐strike landing pattern. Therefore runners who continue to rearfoot‐strike in barefoot may not realize the hypertrophic effects on the plantarflexors, particularly the soleus. These hypertrophic adaptations are beneficial towards endurance related plantarflexor activity. In the third study, a Magnetic Resonance Imaging (MRI) based method of measuring intrinsic foot muscle volume was investigated in order to establish validity and reliability. This was achieved through a comparison with the gold standard—cadaver dissection volume. This study was necessary in order to reliably quantify long term intrinsic foot muscle adaptations in barefoot runners. The results showed excellent intra‐rater validity and reliability for volume measurements of abductor hallucis, abductor digiti minimi, quadratus plantae, and flexor digitorum brevis. The purpose of the fourth study was to quantify foot muscle volume changes and foot bone stress in shod runners who completed a nine‐week transition to true barefoot running. Significant increases of volume were noted in the abductor hallucis and quadratus plantae, driven by adoption of a forefoot‐ or midfoot‐strike landing pattern. The ability to increase intrinsic foot muscle volume, and thereby strength, has clinical implications in the treatment of foot pathologies and in the prevention and rehabilitation of foot injuries in… Advisors/Committee Members: Salem, George J. (Committee Chair), Kulig, Kornelia (Committee Member), Schroeder, E. Todd (Committee Member), Colletti, Patrick M. (Committee Member), Ward, Samuel R. (Committee Member).

Subjects/Keywords: negative‐work; eccentric; training; muscle; tendon; adaptation; hypertrophy; running; barefoot; shod; shoe; transition; foot‐strike pattern; heel‐strike; midfoot‐strike; forefoot‐strike; plantarflexors; calf; foot; intrinsic; magnetic resonance imaging; MRI; ultrasound; dynamometer; electromyography; EMG; injury; prevention; rehabilitation; prehabilitation; validity; reliability; cadaver; bone edema; bone water content; biomechanics; motion analyses; kinematics; kinetics; clinical; anatomy

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APA (6^th Edition):

Samarawickrame, S. D. (2017). Musculotendinous adaptations associated with a functional training program: the transition to barefoot running. (Doctoral Dissertation). University of Southern California. Retrieved from http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/540475/rec/4295

Chicago Manual of Style (16^th Edition):

Samarawickrame, Sachithra D. “Musculotendinous adaptations associated with a functional training program: the transition to barefoot running.” 2017. Doctoral Dissertation, University of Southern California. Accessed March 03, 2021. http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/540475/rec/4295.

MLA Handbook (7^th Edition):

Samarawickrame, Sachithra D. “Musculotendinous adaptations associated with a functional training program: the transition to barefoot running.” 2017. Web. 03 Mar 2021.

Vancouver:

Samarawickrame SD. Musculotendinous adaptations associated with a functional training program: the transition to barefoot running. [Internet] [Doctoral dissertation]. University of Southern California; 2017. [cited 2021 Mar 03]. Available from: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/540475/rec/4295.

Council of Science Editors:

Samarawickrame SD. Musculotendinous adaptations associated with a functional training program: the transition to barefoot running. [Doctoral Dissertation]. University of Southern California; 2017. Available from: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/540475/rec/4295

University of Florida

11. Singh, Guneeta. Size Effects in Phase Separated Manganite Nanostructures.

Degree: PhD, Physics, 2009, University of Florida

URL: https://ufdc.ufl.edu/UFE0024399

► Size Effects in Phase Separated Manganite Nanostructures This work describes a detailed nanometer scale experimental study of a phenomenon known as phase separation, in a… (more)

▼ Size Effects in Phase Separated Manganite Nanostructures This work describes a detailed nanometer scale experimental study of a phenomenon known as phase separation, in a class of ceramic materials know as the manganites. The manganite (La,Pr,Ca)MnO3 was chosen for the studies due to the micrometer scale phase separation in this particular material. In (La,Pr,Ca)MnO3 phase separation is electronic, magnetic and structural in nature, and occurs within a small window of temperatures. Within this temperature range the sample becomes electronically `texturized' in that the sample is no longer homogeneously insulating or conducting, even though the physical chemistry and properties of the sample remain constant. It contains a mix of both insulating and conducting properties within well defined spatial regions. The regions are on the order of a micrometer. The conducting regions are ferromagnetic and have a psuedo cubic (orthorhombic but very nearly cubic) atomic structure while the insulating regions are anitiferromagnetic with an orthorhombic, distorted structure. To understand the physics of the individual phase separated regions a technique was developed for fabricating narrow (La,Pr,Ca)MnO3 wires (in the shape of bridges) of nanometer width such that during the phase separated temperature range, one or a few phase separated regions form along the length of the wire. This has allowed transport measurements across a discrete number of phase separated regions giving physical insights into the nature of the individual regions and the boundaries between them. In this way, it is possible to identify several distinct physical mechanisms that act simultaneously on the nanometer scale giving rise to the unusual properties observed in bulk or unpatterned thin film samples. Transport measurements across the narrow bridges as a function of temperature and magnetic field revealed evidence of alternating insulating and metallic regions spanning the bridge width, aligned along the length of the bridge. First, evidence of direct electron tunneling between two or more ferromagnetic metallic (FM) regions separated by antiferromagnetic insulating (AFI) regions was observed. Magnetoresistance measurements reveal that often, the ferromagnetic metallic regions have different coercive fields (possibly due to varying sizes) which affect the tunnel probabilities (i.e. the probability decreases when the spins are anti-aligned). This gives rise to large and sharp low field peaks when resistance is measured as a function of magnetic field – the classical signature of tunneling magnetoresistance (TMR). Further, signatures of an exchange bias which gives rise to asymmetric TMR peaks were also identified in the measurements. These two phenomenon can help explain anomalous low field magnetoresistance observed in bulk and unpatterned thin film samples. The data also reveal that at temperatures below the phase separated temperature range, when the unpatterned thin film samples are nearly fully ferromagnetic metallic, the narrow bridges in contrast… Advisors/Committee Members: Hebard, Arthur F. (committee chair), Biswas, Amlan (committee member), Hirschfeld, Peter J. (committee member), Tanner, David B. (committee member), Nino, Juan C. (committee member).

Subjects/Keywords: Capacitance; Electric current; Electric fields; Electrical phases; Magnetic fields; Magnetism; Magnets; Orbitals; Thin films; Transition temperature; bias, blockade, colossal, coulomb, domain, electroresistance, exchange, film, insulating, intrinsic, laprcamno, magnetiresistance, magnetoresistance, manganite, nano, nanofabrication, nanostructures, perovskite, phase, polarization, separation, simmons, spin, stripe, thin, tunneling, wall

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Singh, G. (2009). Size Effects in Phase Separated Manganite Nanostructures. (Doctoral Dissertation). University of Florida. Retrieved from https://ufdc.ufl.edu/UFE0024399

Chicago Manual of Style (16^th Edition):

Singh, Guneeta. “Size Effects in Phase Separated Manganite Nanostructures.” 2009. Doctoral Dissertation, University of Florida. Accessed March 03, 2021. https://ufdc.ufl.edu/UFE0024399.

MLA Handbook (7^th Edition):

Singh, Guneeta. “Size Effects in Phase Separated Manganite Nanostructures.” 2009. Web. 03 Mar 2021.

Vancouver:

Singh G. Size Effects in Phase Separated Manganite Nanostructures. [Internet] [Doctoral dissertation]. University of Florida; 2009. [cited 2021 Mar 03]. Available from: https://ufdc.ufl.edu/UFE0024399.

Council of Science Editors:

Singh G. Size Effects in Phase Separated Manganite Nanostructures. [Doctoral Dissertation]. University of Florida; 2009. Available from: https://ufdc.ufl.edu/UFE0024399

12. Thakkar, Balmukund. A Biofocussed Chemoprospecting Approach to Drug Discovery: Design, Synthesis and Bioactivity Screening of Diverse Biofocussed Chemical Libraries .

Degree: 2017, Universitetet i Tromsø

URL: http://hdl.handle.net/10037/11155

► With pharma R & D witnessing rising cost, high attrition rates and an overall decline in productivity in recent times, newer approaches are needed for… (more)

Subjects/Keywords: VDP::Mathematics and natural science: 400::Chemistry: 440::Organic chemistry: 441; Synthesis, Peptide coupling, Cyclization, Tartaric acid bisamides, Piperazine-2,5-diones, Dipeptide esters, Tartrimides, Diversity oriented synthesis; VDP::Mathematics and natural science: 400::Chemistry: 440::Theoretical chemistry, quantum chemistry: 444; Density functional theory, Geometry optimization, Transition state search, Intrinsic reaction coordinates, Conformational search, B3LYP, DFT; VDP::Mathematics and natural science: 400::Chemistry: 440::Pharmaceutical chemistry: 448; Drug discovery, Hit-generation, Lead optimization, Bioprospecting, Chemoprospecting, Biofocussed chemoprospecting, Peptidomimetics, Cheminformatics, Computer aided drug design (CADD), Docking, Homology modelling; VDP::Matematikk og Naturvitenskap: 400::Kjemi: 440::Organisk kjemi: 441; VDP::Matematikk og Naturvitenskap: 400::Kjemi: 440::Teoretisk kjemi, kvantekjemi: 444; VDP::Matematikk og Naturvitenskap: 400::Kjemi: 440::Legemiddelkjemi: 448

…Highest occupied molecular orbital HPLC – High performance liquid chromatography IRC – Intrinsic… …Tetrahydrofuran TS – Transition state TSanti 120 – Transition state geometry of anti type, with ω values… …near 120º TSG – Transition state geometry – obtained with transition state search method… …with only one imaginary frequency TSsyn 60 – Transition state geometry of syn type with ω…

11 more images…

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Thakkar, B. (2017). A Biofocussed Chemoprospecting Approach to Drug Discovery: Design, Synthesis and Bioactivity Screening of Diverse Biofocussed Chemical Libraries . (Doctoral Dissertation). Universitetet i Tromsø. Retrieved from http://hdl.handle.net/10037/11155

Chicago Manual of Style (16^th Edition):

Thakkar, Balmukund. “A Biofocussed Chemoprospecting Approach to Drug Discovery: Design, Synthesis and Bioactivity Screening of Diverse Biofocussed Chemical Libraries .” 2017. Doctoral Dissertation, Universitetet i Tromsø. Accessed March 03, 2021. http://hdl.handle.net/10037/11155.

MLA Handbook (7^th Edition):

Thakkar, Balmukund. “A Biofocussed Chemoprospecting Approach to Drug Discovery: Design, Synthesis and Bioactivity Screening of Diverse Biofocussed Chemical Libraries .” 2017. Web. 03 Mar 2021.

Vancouver:

Thakkar B. A Biofocussed Chemoprospecting Approach to Drug Discovery: Design, Synthesis and Bioactivity Screening of Diverse Biofocussed Chemical Libraries . [Internet] [Doctoral dissertation]. Universitetet i Tromsø 2017. [cited 2021 Mar 03]. Available from: http://hdl.handle.net/10037/11155.

Council of Science Editors:

Thakkar B. A Biofocussed Chemoprospecting Approach to Drug Discovery: Design, Synthesis and Bioactivity Screening of Diverse Biofocussed Chemical Libraries . [Doctoral Dissertation]. Universitetet i Tromsø 2017. Available from: http://hdl.handle.net/10037/11155

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Open Access Theses and Dissertations