subject:(Intranasal)

1. Tukra, Rishabh. Investigation of intercellular transport and biodistribution of curcumin across the nasal epithelium in hamsters.

Degree: M.S. in Pharmaceutical Sciences, Pharmaceutical Science (graduate program), 2016, Creighton University

URL: http://hdl.handle.net/10504/90237

► Since the 1980s, there continues to be reports investigating potential routes for the delivery of compounds to the brain after instillation in the nasal cavity.… (more)

▼ Since the 1980s, there continues to be reports investigating potential routes for the delivery of compounds to the brain after instillation in the nasal cavity. The exact mechanism(s) by which compound translocation from the nose to the brain occurs are unknown. Several hypothesized pathways for compound transport have been proposed and include movement through various nerves in the nasal cavity, the nasal vasculature, or the nasal lymphatic system. However, intercellular transport of large volumes of intranasally instilled inoculum between nasal epithelial cells has been recently reported in hamsters. Intercellular transport in the nose could potentially be used for the non-invasive delivery of drugs to the brain. This thesis looks at the possibility of intercellular transport across the nasal mucosa for the purpose of drug delivery to the brain. |Two liquids were formulated that contained a visual probe suspended in either crude brain homogenate (BH) or a dilute polymer solution. Visual probe suspensions were characterized for the particle size distribution of the visual probe, suspension viscosity, and surface tension. Suspensions were instilled into the noses of hamsters and compared for intercellular transport and biodistribution of the visual probe. Visual probe transport was evaluated in animal groups at 15 and 30 min after inhalation and compared to uninoculated controls and in control animals that received brain homogenate without visual probe. Organs were collected and evaluated for the presence of the visual probe using a validated analytical method using ultra-high pressure chromatography (UPLC). BH-visual probe given to animals that were sacrificed 15 min after inhalation showed intercellular transport between the epithelial cells. BH-curcumin was also found in the lymph vessels of one of the animal that received BH-visual probe suspension and was sacrificed 15 min after inhalation. There was no visual probe detected in any organ 30 min after inhalation of any formulations. Advisors/Committee Members: Tolman, Justin (advisor), Tukra, Rishabh (cuauthor).

Subjects/Keywords: Administration, Intranasal – methods; Curcumin – therapy

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Tukra, R. (2016). Investigation of intercellular transport and biodistribution of curcumin across the nasal epithelium in hamsters. (Masters Thesis). Creighton University. Retrieved from http://hdl.handle.net/10504/90237

Chicago Manual of Style (16^th Edition):

Tukra, Rishabh. “Investigation of intercellular transport and biodistribution of curcumin across the nasal epithelium in hamsters.” 2016. Masters Thesis, Creighton University. Accessed January 23, 2021. http://hdl.handle.net/10504/90237.

MLA Handbook (7^th Edition):

Tukra, Rishabh. “Investigation of intercellular transport and biodistribution of curcumin across the nasal epithelium in hamsters.” 2016. Web. 23 Jan 2021.

Vancouver:

Tukra R. Investigation of intercellular transport and biodistribution of curcumin across the nasal epithelium in hamsters. [Internet] [Masters thesis]. Creighton University; 2016. [cited 2021 Jan 23]. Available from: http://hdl.handle.net/10504/90237.

Council of Science Editors:

Tukra R. Investigation of intercellular transport and biodistribution of curcumin across the nasal epithelium in hamsters. [Masters Thesis]. Creighton University; 2016. Available from: http://hdl.handle.net/10504/90237

Kansas State University

2. Bornheim, Heather. Priming antibody responses against BRSV induced in beef calves through early vaccination.: Antibody responses induced in beef calves through early vaccination.

Degree: MSin Biomedical Sciences, Department of Biomedical Sciences, 2020, Kansas State University

URL: http://hdl.handle.net/2097/40876

► Bovine respiratory syncytial virus (BRSV) plays an important role in the presentation of bovine respiratory disease (BRD) in young beef calves; however, current vaccination protocols… (more)

▼ Bovine respiratory syncytial virus (BRSV) plays an important role in the presentation of bovine respiratory disease (BRD) in young beef calves; however, current vaccination protocols against BRSV have not significantly reduced BRD-associated morbidity and mortality. The objective of this study was to evaluate serum and nasal secretion antibody responses to BRSV in beef calves following vaccination with two different protocols. Within 24-hours-of-life, sixty purebred beef calves were assigned to one of three different treatment groups. Group IN VAC received an intranasal (IN) modified-live (MLV) BRSV vaccine at birth and a subcutaneous (SQ) MLV BRSV vaccine at 2-months. Group SQ VAC received a SQ MLV BRSV vaccine at birth and an IN MLV BRSV vaccine at 2-months while group NO VAC was not vaccinated at birth and received an IN MLV BRSV vaccine at 2-months-of-age. Nasal secretion and serum samples were collected for assessment of BRSV antibodies prior to vaccination at <24 hours, 2-months, and 6-months-of-age. The titers of BRSV antibodies in nasal secretions and serum were similar among treatment groups. At birth, the mean log-transformed BRSV nasal IgA titers were negligible in all groups. At 2-months-of-age, the mean log-transformed BRSV nasal IgA titers in IN-SC VAC, SC-IN VAC, and NO-IN VAC calves were 192.84, 224.49, and 114.71, respectively. At 6-months-of-age, the mean log-transformed BRSV nasal IgA titers in IN-SC, SC-IN, and NO-IN calves were 178.84, 159.33, and 266.62, respectively; however, statistical significance in BRSV IgA titers was not detected among treatment groups at any time point. The model-adjusted mean-Log2 serum BRSV antibody titers were similar among calves from all treatment groups at each sampling point. Early vaccination with MLV BRSV vaccines in a combination protocol at birth and at 2-months-of-age was not different from single IN MLV vaccination at 2-months-of-age inducing nasal or serum BRSV-specific antibody responses in beef calves under the conditions of this study. Advisors/Committee Members: Emily Reppert.

Subjects/Keywords: BRSV; Vaccination; Priming; IgA; Intranasal

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Bornheim, H. (2020). Priming antibody responses against BRSV induced in beef calves through early vaccination.: Antibody responses induced in beef calves through early vaccination. (Masters Thesis). Kansas State University. Retrieved from http://hdl.handle.net/2097/40876

Chicago Manual of Style (16^th Edition):

Bornheim, Heather. “Priming antibody responses against BRSV induced in beef calves through early vaccination.: Antibody responses induced in beef calves through early vaccination.” 2020. Masters Thesis, Kansas State University. Accessed January 23, 2021. http://hdl.handle.net/2097/40876.

MLA Handbook (7^th Edition):

Bornheim, Heather. “Priming antibody responses against BRSV induced in beef calves through early vaccination.: Antibody responses induced in beef calves through early vaccination.” 2020. Web. 23 Jan 2021.

Vancouver:

Bornheim H. Priming antibody responses against BRSV induced in beef calves through early vaccination.: Antibody responses induced in beef calves through early vaccination. [Internet] [Masters thesis]. Kansas State University; 2020. [cited 2021 Jan 23]. Available from: http://hdl.handle.net/2097/40876.

Council of Science Editors:

Bornheim H. Priming antibody responses against BRSV induced in beef calves through early vaccination.: Antibody responses induced in beef calves through early vaccination. [Masters Thesis]. Kansas State University; 2020. Available from: http://hdl.handle.net/2097/40876

Technical University of Lisbon

3. Leal, Sofia Mafalda Ramos. Neoplasias sinonasais caninas : revisão bibliográfica e estudo de casos.

Degree: 2017, Technical University of Lisbon

URL: http://www.rcaap.pt/detail.jsp?id=oai:www.repository.utl.pt:10400.5/13066

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Dissertação de Mestrado Integrado em Medicina Veterinária

As neoplasias sinonasais caninas são raras constituindo cerca de 1 a 2% de todas as neoplasias caninas. A… (more)

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Dissertação de Mestrado Integrado em Medicina Veterinária

As neoplasias sinonasais caninas são raras constituindo cerca de 1 a 2% de todas as neoplasias caninas. A maioria dos tumores com origem na cavidade nasal ou seios paranasais são malignos. Os carcinomas representam a maioria das neoplasias sinonasais no cão, sendo o adenocarcinoma o tumor mais comum. Independentemente do tipo histológico, a invasão das estruturas envolventes é extensa e ocorre frequente e rapidamente, com rara metastização sistémica. O diagnóstico é um desafio - as limitações anatómicas são dificilmente contornáveis e as infeções secundárias poderão mascarar o processo. Como a invasão óssea ocorre numa fase precoce do processo, o recurso a cirurgia com intenção curativa é poucas vezes equacionado. Deste modo, o tratamento é direcionado para o controlo da doença local, sendo a radioterapia o tratamento preferencial. Contudo muitas dúvidas persistem sobre o método ideal de estadiamento e o protocolo radioterápico de eleição. Com recurso a radioterapia os tempos de sobrevivência variam entre 8 e 14 meses. Num país em que esta opção não está disponível, o recurso a diferentes estratégias terapêuticas, como a quimioterapia, torna-se essencial para prolongar o tempo e a qualidade de vida de pacientes com neoplasias intranasais. Até à data são escassos os estudos que referem o uso de quimioterapia como abordagem terapêutica única no tratamento das neoplasias sinonasais caninas. Este trabalho tem por objetivo analisar o tempo médio de sobrevivência e as características epidemiológicas de uma população de canídeos diagnosticados com neoplasias sinonasais e tratados com quimioterapia. O estudo engloba dez casos clínicos de neoplasias sinonasais caninas cujo diagnóstico foi confirmado por citologia e/ou histopatologia. Foram incluídos casos cujo tratamento farmacológico consistiu em administrações de doxorrubicina, carboplatina e ciclofosfamida em protocolos combinados ou como agentes quimioterápicos únicos. Os resultados obtidos permitiram verificar que a sobrevivência média dos canídeos em estudo foi de 408 dias (aproximadamente 13,6 meses). Estes resultados são animadores principalmente quando comparados com TMS (tempo médio de sobrevivência) descritos em estudos cujos pacientes não tiveram acesso a qualquer tipo de tratamento. O valor do TMS descrito neste estudo é comparável a valores identificados em alguns dos estudos em que se recorre a radioterapia com intenção curativa, embora calculado com base numa amostra mais pequena e baseado num desenho experimental retrospetivo. Os efeitos secundários associados ao tratamento quimioterápico foram bem tolerados tendo sido resolvidos com tratamento de suporte. Conclui-se que a quimioterapia poderá ser uma alternativa razoável à radioterapia no tratamento de tumores sinonasais em cães quando a mesma não está disponível e poderá prolongar o TMS quando comparado com cães com neoplasias sinonasais não submetidos a tratamento. As características epidemiológicas (género, raça, idade de apresentação,…

Advisors/Committee Members: Henriques, Joaquim Garcia Pereira, Correia, José Henrique Duarte.

Subjects/Keywords: Cão; Neoplasia; Sinonasal; Intranasal; Dog; Tumor; Nasosinal

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Leal, S. M. R. (2017). Neoplasias sinonasais caninas : revisão bibliográfica e estudo de casos. (Thesis). Technical University of Lisbon. Retrieved from http://www.rcaap.pt/detail.jsp?id=oai:www.repository.utl.pt:10400.5/13066

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Leal, Sofia Mafalda Ramos. “Neoplasias sinonasais caninas : revisão bibliográfica e estudo de casos.” 2017. Thesis, Technical University of Lisbon. Accessed January 23, 2021. http://www.rcaap.pt/detail.jsp?id=oai:www.repository.utl.pt:10400.5/13066.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Leal, Sofia Mafalda Ramos. “Neoplasias sinonasais caninas : revisão bibliográfica e estudo de casos.” 2017. Web. 23 Jan 2021.

Vancouver:

Leal SMR. Neoplasias sinonasais caninas : revisão bibliográfica e estudo de casos. [Internet] [Thesis]. Technical University of Lisbon; 2017. [cited 2021 Jan 23]. Available from: http://www.rcaap.pt/detail.jsp?id=oai:www.repository.utl.pt:10400.5/13066.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Leal SMR. Neoplasias sinonasais caninas : revisão bibliográfica e estudo de casos. [Thesis]. Technical University of Lisbon; 2017. Available from: http://www.rcaap.pt/detail.jsp?id=oai:www.repository.utl.pt:10400.5/13066

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universidade do Rio Grande do Sul

4. Ramos, Denise Barbosa. Avaliação do perfil farmacocinético da administração intranasal de guanosina e seu potencial neuroprotetor em um modelo de isquemia do córtex parietal cerebral por termocoagulação em ratos.

Degree: 2013, Universidade do Rio Grande do Sul

URL: http://hdl.handle.net/10183/90099

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A isquemia cerebral é uma das principais causas de morte no mundo, sendo decorrente de uma interrupção transitória ou permanente do fluxo sanguíneo, podendo levar… (more)

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A isquemia cerebral é uma das principais causas de morte no mundo, sendo decorrente de uma interrupção transitória ou permanente do fluxo sanguíneo, podendo levar à massiva morte neuronal. Um dos eventos neurotóxicos relacionados à isquemia é o aumento excessivo da concentração de glutamato extracelular, o que leva a hiperestimulação do sistema glutamatérgico (excitotoxicidade) podendo assim desencadear uma cascata de eventos intracelulares nos neurônios culminando em sua morte. Nos últimos anos, o nucleosídeo guanosina tem ganhado atenção dos pesquisadores devido ao seu potencial efeito neuroprotetor frente a insultos envolvendo excitotoxicidade. Na maioria dos experimentos in vivo no qual foram observados efeitos neuroprotetores, a guanosina foi administrada sistemicamente, apresentando considerável variabilidade na magnitude de seus efeitos entre os animais. Dado que a guanosina é uma molécula endógena, podendo ser rapidamente metabolizada via sistêmica até alcançar o cérebro, novas vias de administração devem ser exploradas a fim de maximizar seus efeitos neuroprotetores. A administração pela via intranasal tem se mostrado uma excelente alternativa visto que a boa perfusão da mucosa nasal fornece um excelente local para uma rápida absorção de drogas e transporte para o cérebro via líquido cefalorraquidiano (liquor). Neste sentido, nesta dissertação avaliamos o perfil farmacocinético da administração intranasal de guanosina e seu potencial neuroprotetor em um modelo de isquemia do córtex parietal cerebral por termocoagulação em ratos. Desta maneira, investigamos a concentração de guanosina e seus metabólitos em diferentes estruturas cerebrais, além do liquor e plasma após administração de diferentes doses, volumes de injeção e tempos após injeção intranasal de guanosina pelos métodos de CLAE e de quantificação de radioatividade. Houve diferenças significativas na concentração de purinas presentes nas estruturas analisadas (bulbo, córtex e hipocampo) além do liquor e do plasma. Observamos uma proporcionalidade entre o aumento significativo de radioatividade em relação ao aumento da concentração e do volume. Além disso, comparamos os parâmetros, acima citados, de animais que receberam administração de guanosina pela via intranasal ou intraperitoneal ou não receberam guanosina, apresentando diferenças significativas entre os grupos analisados. A indução isquêmica causou prejuízo sensoriomotor e lesão cerebral nos animais, os quais foram revertidos pelo tratamento com guanosina. Além disso, diferenças significativas na concentração das purinas foram observadas no plasma e no liquor desses animais as quais podem estar envolvidas tanto com o dano nos animais isquêmicos quanto com o efeito neuroprotetor da guanosina. Assim, este trabalho é o pioneiro mostrando a viabilidade da administração intranasal de guanosina, além de reforçar o efeito neuroprotetor da mesma frente a um modelo de isquemia.

Cerebral ischemia is a major cause of death worldwide is caused by a transient or permanent interruption of blood flow and…

Advisors/Committee Members: Ganzella, Marcelo.

Subjects/Keywords: Isquemia encefálica; Guanosina; Administração intranasal; Neuroproteção

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Ramos, D. B. (2013). Avaliação do perfil farmacocinético da administração intranasal de guanosina e seu potencial neuroprotetor em um modelo de isquemia do córtex parietal cerebral por termocoagulação em ratos. (Thesis). Universidade do Rio Grande do Sul. Retrieved from http://hdl.handle.net/10183/90099

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Ramos, Denise Barbosa. “Avaliação do perfil farmacocinético da administração intranasal de guanosina e seu potencial neuroprotetor em um modelo de isquemia do córtex parietal cerebral por termocoagulação em ratos.” 2013. Thesis, Universidade do Rio Grande do Sul. Accessed January 23, 2021. http://hdl.handle.net/10183/90099.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Ramos, Denise Barbosa. “Avaliação do perfil farmacocinético da administração intranasal de guanosina e seu potencial neuroprotetor em um modelo de isquemia do córtex parietal cerebral por termocoagulação em ratos.” 2013. Web. 23 Jan 2021.

Vancouver:

Ramos DB. Avaliação do perfil farmacocinético da administração intranasal de guanosina e seu potencial neuroprotetor em um modelo de isquemia do córtex parietal cerebral por termocoagulação em ratos. [Internet] [Thesis]. Universidade do Rio Grande do Sul; 2013. [cited 2021 Jan 23]. Available from: http://hdl.handle.net/10183/90099.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Ramos DB. Avaliação do perfil farmacocinético da administração intranasal de guanosina e seu potencial neuroprotetor em um modelo de isquemia do córtex parietal cerebral por termocoagulação em ratos. [Thesis]. Universidade do Rio Grande do Sul; 2013. Available from: http://hdl.handle.net/10183/90099

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Guelph

5. Ollivett, Theresa. Understanding the diagnosis and risk factors for respiratory disease in dairy calves.

Degree: PhD, Department of Population Medicine, 2014, University of Guelph

URL: https://atrium.lib.uoguelph.ca/xmlui/handle/10214/8129

► The purpose of the work presented in this thesis was to evaluate the use of portable ultrasonography (US) for the diagnosis of respiratory disease in… (more)

▼ The purpose of the work presented in this thesis was to evaluate the use of portable ultrasonography (US) for the diagnosis of respiratory disease in dairy calves. In addition to testing diagnostic accuracy of US, the efficacy of an intranasal vaccine against viral pathogens and the short-term effects of respiratory disease on calf behavior were evaluated. In calves affected with subclinical respiratory disease, the sensitivity and specificity of US in diagnosing lung lesions was 94% (95% CI: 69 100%) and 100% (95% CI: 64 100%), respectively; and the presence of US lung lesions predicted a neutrophil proportion ≥ 4% in bronchoalveolar lavage fluid (OR = 23; 95% CI: 2.6 – 198; P < 0.01). Ultrasonographic lesions were highly correlated to post-mortem lesions (r = 0.92; P < 0.01). After experimental bacterial infection, lesions associated with bronchopneumonia developed rapidly, and progressed to maximum size over 48 hours, after which the lesions remained stable for several days. The odds of observing lung lesions were lower in calves that were vaccinated within the 1st week of life and 6 weeks of age with an intranasal viral respiratory vaccine as compared to calves subjected to a positive or negative control vaccination protocol. Intranasal vaccine was associated with average daily gain within the 1st 8 weeks of life, although this relationship was farm dependent. The presence of lesions as detected by ultrasonography had no effect on lying behavior of young dairy calves. The portable US machine carried by bovine practitioners provided a practical means to accurately assess lung lesions in dairy calves. This tool will help practitioners assist producers in making well-informed treatment and management decisions, hopefully serving to improve both calf health and welfare. Additionally, from a research perspective, this equipment will reduce the number of calves used to study respiratory disease and allow for new outcomes to be measured including the onset, duration, and resolution of lung lesions as we study the impact they have on future performance. Advisors/Committee Members: Kelton, David (advisor), Duffield, Todd (advisor).

Subjects/Keywords: dairy calves; respiratory disease; ultrasonography; intranasal vaccine

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Ollivett, T. (2014). Understanding the diagnosis and risk factors for respiratory disease in dairy calves. (Doctoral Dissertation). University of Guelph. Retrieved from https://atrium.lib.uoguelph.ca/xmlui/handle/10214/8129

Chicago Manual of Style (16^th Edition):

Ollivett, Theresa. “Understanding the diagnosis and risk factors for respiratory disease in dairy calves.” 2014. Doctoral Dissertation, University of Guelph. Accessed January 23, 2021. https://atrium.lib.uoguelph.ca/xmlui/handle/10214/8129.

MLA Handbook (7^th Edition):

Ollivett, Theresa. “Understanding the diagnosis and risk factors for respiratory disease in dairy calves.” 2014. Web. 23 Jan 2021.

Vancouver:

Ollivett T. Understanding the diagnosis and risk factors for respiratory disease in dairy calves. [Internet] [Doctoral dissertation]. University of Guelph; 2014. [cited 2021 Jan 23]. Available from: https://atrium.lib.uoguelph.ca/xmlui/handle/10214/8129.

Council of Science Editors:

Ollivett T. Understanding the diagnosis and risk factors for respiratory disease in dairy calves. [Doctoral Dissertation]. University of Guelph; 2014. Available from: https://atrium.lib.uoguelph.ca/xmlui/handle/10214/8129

University of Otago

6. Osborne, Jonathan Robert. Intranasal VEGF-A and VEGF-E in a modified Levine model of stroke .

Degree: 2013, University of Otago

URL: http://hdl.handle.net/10523/3894

► VEGF (Vascular endothelial growth factor)-A has been shown to successfully enter the brain via the intranasal pathway and improve symptoms following focal ischemia in rats.… (more)

Subjects/Keywords: VEGF; stroke; intranasal; ischemia; VEGF-E

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Osborne, J. R. (2013). Intranasal VEGF-A and VEGF-E in a modified Levine model of stroke . (Masters Thesis). University of Otago. Retrieved from http://hdl.handle.net/10523/3894

Chicago Manual of Style (16^th Edition):

Osborne, Jonathan Robert. “Intranasal VEGF-A and VEGF-E in a modified Levine model of stroke .” 2013. Masters Thesis, University of Otago. Accessed January 23, 2021. http://hdl.handle.net/10523/3894.

MLA Handbook (7^th Edition):

Osborne, Jonathan Robert. “Intranasal VEGF-A and VEGF-E in a modified Levine model of stroke .” 2013. Web. 23 Jan 2021.

Vancouver:

Osborne JR. Intranasal VEGF-A and VEGF-E in a modified Levine model of stroke . [Internet] [Masters thesis]. University of Otago; 2013. [cited 2021 Jan 23]. Available from: http://hdl.handle.net/10523/3894.

Council of Science Editors:

Osborne JR. Intranasal VEGF-A and VEGF-E in a modified Levine model of stroke . [Masters Thesis]. University of Otago; 2013. Available from: http://hdl.handle.net/10523/3894

7. Johansson, Herman. Vårdandet av patienter som behandlas med intranasal smärtlindring inom ambulanssjukvård : En kvalitativ studie av sjuksköterskors erfarenheter.

Degree: Work Life and Social Welfare, 2015, University of Borås

URL: http://urn.kb.se/resolve?urn=urn:nbn:se:hb:diva-3325

► Inom ambulanssjukvård är en av ambulanssjuksköterskans uppgifter att kunna ge patienten adekvat smärtlindring. Tidigare har det krävts en intravenös infart för detta, men sedan… (more)

Subjects/Keywords: intranasal administrering; Fentanyl; akut smärta; sjuksköterskans erfarenheter

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Johansson, H. (2015). Vårdandet av patienter som behandlas med intranasal smärtlindring inom ambulanssjukvård : En kvalitativ studie av sjuksköterskors erfarenheter. (Thesis). University of Borås. Retrieved from http://urn.kb.se/resolve?urn=urn:nbn:se:hb:diva-3325

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Johansson, Herman. “Vårdandet av patienter som behandlas med intranasal smärtlindring inom ambulanssjukvård : En kvalitativ studie av sjuksköterskors erfarenheter.” 2015. Thesis, University of Borås. Accessed January 23, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:hb:diva-3325.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Johansson, Herman. “Vårdandet av patienter som behandlas med intranasal smärtlindring inom ambulanssjukvård : En kvalitativ studie av sjuksköterskors erfarenheter.” 2015. Web. 23 Jan 2021.

Vancouver:

Johansson H. Vårdandet av patienter som behandlas med intranasal smärtlindring inom ambulanssjukvård : En kvalitativ studie av sjuksköterskors erfarenheter. [Internet] [Thesis]. University of Borås; 2015. [cited 2021 Jan 23]. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:hb:diva-3325.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Johansson H. Vårdandet av patienter som behandlas med intranasal smärtlindring inom ambulanssjukvård : En kvalitativ studie av sjuksköterskors erfarenheter. [Thesis]. University of Borås; 2015. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:hb:diva-3325

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

McMaster University

8. Simpson, Madeline J. Highly Tunable and Degradable Hydrophobized Nanogels for the Intranasal Delivery of Poorly-Water Soluble Antipsychotic Drugs to the Brain.

Degree: PhD, 2020, McMaster University

URL: http://hdl.handle.net/11375/25981

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Nanogels are soft, deformable networks of cross-linked polymer swollen in water. Nanogels have the unique ability to swell in response to external physiological conditions. Their… (more)

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Nanogels are soft, deformable networks of cross-linked polymer swollen in water. Nanogels have the unique ability to swell in response to external physiological conditions. Their stimuli-responsive nature affects degradability, drug uptake and release, which can be exploited to create tunable drug delivery systems. The ability to alter the composition and structure of nanogels imparts advantageous characteristics for targeted drug delivery applications. Antipsychotic drugs (APDs) used to treat schizophrenia, a chronic neuropsychiatric disorder, are typically hydrophobic. Prolonged dosing causes neurological and metabolic side effects due to the systemic administration of drug. Patient adherence to APD administration is low, causing complications that contribute to the substantial burden of disease. APDs would benefit from nanogel encapsulation through improved solubility and controlled release kinetics to reduce the adverse side effects associated with typical administration protocols. This thesis presents the development of hydrophobized, biodegradable poly(oligoethylene glycol methacrylate) (POEGMA)-based nanogels to deliver APDs to the brain. Both an adaptation of conventional precipitation polymerization as well as a spontaneous self-assembly technique are utilized to synthesize nanogels containing different hydrophobic domains. Incorporation of cross-linkers with different modalities of biodegradability enable stimuli-responsive degradation and drug release. The effects on nanogel swelling, biodegradability, and APD uptake and release kinetics are explored in vitro. The preclinical application of these APD-loaded nanogels is evaluated using the minimally invasive intranasal (IN) route for delivery. We show that these nanogel delivery systems have therapeutic effects in terms of significantly altering a range of rodent behaviours, including locomotion inhibition, the onset of catalepsy, and improvement in pre-pulse inhibition, over extended periods of time in relation to current administration strategies. These drug-loaded nanogel delivery systems show potential to minimize the effective therapeutic dose by enhancing APD bioavailability via IN administration, thus reducing adverse outcomes and improving potential patient adherence to APD-based therapies in clinical use.

Thesis

Doctor of Philosophy (PhD)

Nanogels are soft, deformable polymer networks swollen in water with potential for drug delivery given their easy-to-tune physicochemical properties. However, the poor water solubility of many therapeutics, including antipsychotic drugs (APDs) used to treat schizophrenia, limits drug encapsulation within nanogels. In addition, conventional synthetic techniques produce materials that degrade into poorly-defined byproducts, causing toxicity concerns. This thesis presents novel strategies to incorporate hydrophobic domains and biodegradable bonds within poly(oligo ethylene glycol methacrylate) (POEGMA) nanogels. We demonstrate how these moieties affect nanogel swelling, degradability,…

Advisors/Committee Members: Hoare, Todd, Chemical Engineering.

Subjects/Keywords: Nanogel; Drug Delivery; Intranasal; Antipsychotic Drugs

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Simpson, M. J. (2020). Highly Tunable and Degradable Hydrophobized Nanogels for the Intranasal Delivery of Poorly-Water Soluble Antipsychotic Drugs to the Brain. (Doctoral Dissertation). McMaster University. Retrieved from http://hdl.handle.net/11375/25981

Chicago Manual of Style (16^th Edition):

Simpson, Madeline J. “Highly Tunable and Degradable Hydrophobized Nanogels for the Intranasal Delivery of Poorly-Water Soluble Antipsychotic Drugs to the Brain.” 2020. Doctoral Dissertation, McMaster University. Accessed January 23, 2021. http://hdl.handle.net/11375/25981.

MLA Handbook (7^th Edition):

Simpson, Madeline J. “Highly Tunable and Degradable Hydrophobized Nanogels for the Intranasal Delivery of Poorly-Water Soluble Antipsychotic Drugs to the Brain.” 2020. Web. 23 Jan 2021.

Vancouver:

Simpson MJ. Highly Tunable and Degradable Hydrophobized Nanogels for the Intranasal Delivery of Poorly-Water Soluble Antipsychotic Drugs to the Brain. [Internet] [Doctoral dissertation]. McMaster University; 2020. [cited 2021 Jan 23]. Available from: http://hdl.handle.net/11375/25981.

Council of Science Editors:

Simpson MJ. Highly Tunable and Degradable Hydrophobized Nanogels for the Intranasal Delivery of Poorly-Water Soluble Antipsychotic Drugs to the Brain. [Doctoral Dissertation]. McMaster University; 2020. Available from: http://hdl.handle.net/11375/25981

University of Minnesota

9. Rautiola, Davin. Two-Part Reactive Formulations for Intranasal Delivery of Benzodiazepines.

Degree: PhD, Pharmaceutics, 2019, University of Minnesota

URL: http://hdl.handle.net/11299/208986

► A seizure emergency occurs when an individual experiences a seizure that lasts for more than five minutes (status epilepticus) or multiple distinct seizures with incomplete… (more)

▼ A seizure emergency occurs when an individual experiences a seizure that lasts for more than five minutes (status epilepticus) or multiple distinct seizures with incomplete recovery between them (acute repetitive seizures). A patient experiencing a seizure emergency must be treated as quickly as possible to avoid lasting neurological damage and other life-threatening complications. Benzodiazepines are the primary rescue medications used to treat seizure emergencies, the most commonly used being intravenous lorazepam or rectal diazepam. Despite the effectiveness of these drugs, the delivery routes are not ideal for first-line, outpatient treatments. A skilled caregiver must be present to administer drugs intravenously, and the social stigma associated with rectal administration results in low compliance. Intranasal delivery is an attractive alternative because it requires little training, is easily performed by non-medical personnel, carries a low risk of injury to the patient, and can provide a rapid therapeutic effect. However, formulating a benzodiazepine nasal spray is challenging because these drugs have very low aqueous solubilities. One strategy to circumvent solubility issues relies on in situ production of drug from co-administration of soluble reactants. Herein, we describe how a prodrug/enzyme reaction or an acid/base reaction can be used to deliver a benzodiazepine in an aqueous vehicle with a volume and pH appropriate for intranasal administration. When the soluble components of these two-part reactive formulations are mixed at the time of administration, a metastable supersaturated solution of the benzodiazepine is produced. The supersaturated state of the benzodiazepine provides a large chemical activity gradient for rapid absorption across the nasal mucosa and into systemic circulation. In vitro characterization of the reaction kinetics and supersaturation behaviors for diazepam prodrug/enzyme reactions, midazolam prodrug/enzyme reactions, and midazolam acid/base reactions demonstrated that these two-part formulations generate predictable levels of supersaturated drug. An in vivo pharmacokinetic study in rats showed that rapid absorption and high bioavailability of diazepam results from intranasal administration of a diazepam prodrug/enzyme formulation. Furthermore, a dual chamber nasal spray device capable of mixing and atomizing the components of a two-part formulation was designed, prototyped, and tested. These two-part reactive formulations, coupled with the specialized nasal spray device, exemplify a new intranasal drug delivery strategy that may be applicable to a variety of other drugs with poor stability or low solubility.

Subjects/Keywords: benzodiazepines; intranasal; metastable; prodrug; solubility; supersaturated

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Rautiola, D. (2019). Two-Part Reactive Formulations for Intranasal Delivery of Benzodiazepines. (Doctoral Dissertation). University of Minnesota. Retrieved from http://hdl.handle.net/11299/208986

Chicago Manual of Style (16^th Edition):

Rautiola, Davin. “Two-Part Reactive Formulations for Intranasal Delivery of Benzodiazepines.” 2019. Doctoral Dissertation, University of Minnesota. Accessed January 23, 2021. http://hdl.handle.net/11299/208986.

MLA Handbook (7^th Edition):

Rautiola, Davin. “Two-Part Reactive Formulations for Intranasal Delivery of Benzodiazepines.” 2019. Web. 23 Jan 2021.

Vancouver:

Rautiola D. Two-Part Reactive Formulations for Intranasal Delivery of Benzodiazepines. [Internet] [Doctoral dissertation]. University of Minnesota; 2019. [cited 2021 Jan 23]. Available from: http://hdl.handle.net/11299/208986.

Council of Science Editors:

Rautiola D. Two-Part Reactive Formulations for Intranasal Delivery of Benzodiazepines. [Doctoral Dissertation]. University of Minnesota; 2019. Available from: http://hdl.handle.net/11299/208986

The Ohio State University

10. Watts, Kathryn Teal. An Evaluation of Intranasal Ketorolac in an Untreated Endodontic Pain Model.

Degree: MS, Dentistry, 2018, The Ohio State University

URL: http://rave.ohiolink.edu/etdc/view?acc_num=osu1532509409975989

► Introduction: Previously, ketorolac was available for primary use only via intravenous and intramuscular routes. Its availability in intranasal form offers an alternative route of administration… (more)

Subjects/Keywords: Dentistry; intranasal ketorolac; Sprix; preoperative pain

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Watts, K. T. (2018). An Evaluation of Intranasal Ketorolac in an Untreated Endodontic Pain Model. (Masters Thesis). The Ohio State University. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=osu1532509409975989

Chicago Manual of Style (16^th Edition):

Watts, Kathryn Teal. “An Evaluation of Intranasal Ketorolac in an Untreated Endodontic Pain Model.” 2018. Masters Thesis, The Ohio State University. Accessed January 23, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=osu1532509409975989.

MLA Handbook (7^th Edition):

Watts, Kathryn Teal. “An Evaluation of Intranasal Ketorolac in an Untreated Endodontic Pain Model.” 2018. Web. 23 Jan 2021.

Vancouver:

Watts KT. An Evaluation of Intranasal Ketorolac in an Untreated Endodontic Pain Model. [Internet] [Masters thesis]. The Ohio State University; 2018. [cited 2021 Jan 23]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=osu1532509409975989.

Council of Science Editors:

Watts KT. An Evaluation of Intranasal Ketorolac in an Untreated Endodontic Pain Model. [Masters Thesis]. The Ohio State University; 2018. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=osu1532509409975989

Universidade do Rio Grande do Sul

11. Pinheiro, Sabrina dos Santos. Cetamina intranasal para sedoanalgesia na punção venosaperiférica em pacientes pediátricos : estudo randomizado, duplo cego e placebo controlado.

Degree: 2016, Universidade do Rio Grande do Sul

URL: http://hdl.handle.net/10183/158232

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Objetivos: Verificar eficácia da cetamina intranasal na sedação de crianças para punção venosa. Métodos: Estudo randomizado, duplo-cego, placebo controlado realizado no Hospital de Clínicas de… (more)

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Objetivos: Verificar eficácia da cetamina intranasal na sedação de crianças para punção venosa. Métodos: Estudo randomizado, duplo-cego, placebo controlado realizado no Hospital de Clínicas de Porto Alegre entre janeiro e agosto de 2016. Estudo aprovado pela comissão de ética em pesquisa da instituição. Incluídas crianças que necessitasse de punção venosa, sendo randomizadas a receber cetamina IN 4mg/Kg ou solução fisiológica no grupo Placebo. Os grupos foram comparados quanto: tempo de punção, facilidade do Enfermeiro para realizar o procedimento, eventos adversos, alterações dos sinais vitais e percepção do acompanhante. Resultados: Foram incluídas 39 crianças (21 Intervenção vs 18 Placebo) sem diferenças quanto à idade, sexo, peso, motivo da internação e experiência profissional. A mediana da idade foi 19,8 vs 15,8 meses (Intervenção vs. Placebo) e a do peso foi 10 vs. 11,3Kg. A Cetamina reduziu o tempo de punção (23,0 vs 67,5 segundos; p=0,01), deu maior facilidade ao Enfermeiro para realizar o procedimento (p=0,00009). A cetamina induziu uma maior sonolência 15 minutos após (p=0,003) e reduziu o número de pessoas para contenção da criança (p=0,025). Sem diferença entre os grupos nas alterações dos sinais vitais e eventos adversos. Evento adverso observou-se em 29% das crianças do grupo cetamina e 17% do grupo placebo, sendo irritabilidade o mais comum em ambos. Em 81% do grupo Intervenção, o acompanhante afirmou que a criança ficou mais calma (p=0,0003). Conclusões: Cetamina intranasal (4mg/Kg) reduz o tempo de punção venosa, facilitando o procedimento para o enfermeiro, diminuindo o número de pessoas envolvidas e permitindo um ambiente tranquilo.

Objectives: To verify the efficacy of intranasal ketamine as sedative agent for venous access in children. Method: Randomized, double blind, placebo controlled study conducted at Hospital de Clínicas de Porto Alegre (Brazil) between January and August 2016. Children needing venous access were randomized to receive intranasal ketamine (4mg/Kg) or normal saline solution (Placebo group). Groups were compared regarding the time for venous access, facility for performing the procedure, adverse events, disturbances in vital signs and perception of the accompanying adult. The study was approved by the Local Ethics Committee. Results: 39 children (21 Ketamine; 18 Placebo) were included without differences regarding to age, sex, weight, reason for hospitalization and professional experience. The median age was similar (19.8 vs 15.8 months), as well as the median weight (10.0 vs 11.3Kg). Ketamine reduced the length for venous access (23.0 vs 67.5 seconds; p=0.01), and facilitated the procedure (p=0.00009). Ketamine induced sleepiness 15 minutes after its administration (p=0.003) and reduced the number of people for the child’s restraint (p=0.025). No difference was verified between groups regarding adverse effects or vital signs disturbance´s. Side effects were observed in 29% of the children in the Ketamine group and 17% in the Placebo group, irritability being the most…

Advisors/Committee Members: Piva, Jefferson Pedro.

Subjects/Keywords: Ketamine; Administração intranasal; Conscious sedation; Sedação consciente; Ketamina; Pediatric nurse; Intranasal administration

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Pinheiro, S. d. S. (2016). Cetamina intranasal para sedoanalgesia na punção venosaperiférica em pacientes pediátricos : estudo randomizado, duplo cego e placebo controlado. (Thesis). Universidade do Rio Grande do Sul. Retrieved from http://hdl.handle.net/10183/158232

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Pinheiro, Sabrina dos Santos. “Cetamina intranasal para sedoanalgesia na punção venosaperiférica em pacientes pediátricos : estudo randomizado, duplo cego e placebo controlado.” 2016. Thesis, Universidade do Rio Grande do Sul. Accessed January 23, 2021. http://hdl.handle.net/10183/158232.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Pinheiro, Sabrina dos Santos. “Cetamina intranasal para sedoanalgesia na punção venosaperiférica em pacientes pediátricos : estudo randomizado, duplo cego e placebo controlado.” 2016. Web. 23 Jan 2021.

Vancouver:

Pinheiro SdS. Cetamina intranasal para sedoanalgesia na punção venosaperiférica em pacientes pediátricos : estudo randomizado, duplo cego e placebo controlado. [Internet] [Thesis]. Universidade do Rio Grande do Sul; 2016. [cited 2021 Jan 23]. Available from: http://hdl.handle.net/10183/158232.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Pinheiro SdS. Cetamina intranasal para sedoanalgesia na punção venosaperiférica em pacientes pediátricos : estudo randomizado, duplo cego e placebo controlado. [Thesis]. Universidade do Rio Grande do Sul; 2016. Available from: http://hdl.handle.net/10183/158232

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

12. Haglund, Björn. Intranasal smärtlindring med sufentanil i en prehospital kontext : en kvantitativ studie.

Degree: Sophiahemmet University, 2018, Sophiahemmet University

URL: http://urn.kb.se/resolve?urn=urn:nbn:se:shh:diva-2980

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Sedan början av 2000-talet har ambulanssjukvården haft en snabb utveckling inom flera områden. Möjligheten att administrera smärtlindring har utvecklats och dagens ambulanser är nu… (more)

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Sedan början av 2000-talet har ambulanssjukvården haft en snabb utveckling inom flera områden. Möjligheten att administrera smärtlindring har utvecklats och dagens ambulanser är nu mer välutrustade med ett flertal smärtlindrande preparat att välja mellan. Detta ställer stora krav på den specialistsjuksköterska som vårdar patienten. År 2015 infördes nya läkemedel och även ett, för ambulanssjukvården nytt administreringssätt: intranasalt. En stor andel av patienterna i ambulanssjukvården lider av akut smärta och är således i behov av smärtlindring. Sufentanil är en stark opioid med egenskaper lämpade för intranasal administrering. Det finns dock få prehospitala studier om intranasal smärtlindring generellt och än färre gällande sufentanil. Dessutom har ingen tidigare forskning har jämfört effekten av intranasalt administrerat sufentanil mellan barn, vuxna och äldre. Syftet med denna studie var att beskriva användningen av intranasalt administrerat sufentanil i en prehospital kontext. Vidare studerades frågeställningar gällande grad av smärtlindring, förekomst av biverkningar, etablering av perifer infart, i vilken miljö patienten befann sig samt personalens upplevelser. Författarna analyserade ett antal utvärderingsprotokoll som fyllts i av sjuksköterskor som administrerat intranasalt sufentanil. Studiens data delades upp i tre grupper utifrån deltagarnas ålder. De tre grupperna var barn, vuxna och äldre. Kvantitativ ansats användes och datan analyserades med hjälp av ANOVA och chi2test beroende på datanivå. Jämförande analyser gällande skillnad i medelvärde samt förekomst genomfördes mellan grupperna. Till exempel jämfördes grad av smärtlindring, mängd givet läkemedel samt förekomst av biverkningar mellan grupperna. Resultatet visade att samtliga grupper erhåller en adekvat smärtlindring, vilket definierades som tre poäng eller lägre mätt med visuell analog skala [VAS] vid avlämning på akutmottagningen. Barn erhöll signifikant högre doser jämfört med både vuxna och äldre samt hade en lägre VAS vid avlämning på akutmottagning. Andningsdepression förekom i två fall och då i gruppen äldre. Illamående och kräkningar var den vanligaste biverkan hos vuxna och äldre medan det hos barn var slöhet. I barngruppen så etablerades signifikant färre antal perifera venkatetrar [PVK] jämfört med övriga grupper. Sjuksköterskorna uppskattade att behandlingen hade bäst i effekt på barn och därefter äldre samt vuxna. Slutsatsen var att prehospital administrering av sufentanil tycks ge en bra smärtlindring som ligger inom behandlingsmålet, andelen biverkningar är inte större än i tidigare studier. Däremot visade vårt resultat att barn i viss utsträckning blir slöa vid behandling med intranasalt sufentanil.

Since the beginning of the 2000s, Emergency Medical Services has had rapid development in several areas. The possibility to administer pain relief has been developed and today's ambulances are well-equipped with a variety of pain relief preparations to choose from.…

Subjects/Keywords: Prehospital; Intranasal; Sufentanil; Pain management; VAS; Prehospital; Intranasal; Sufentanil; Smärtbehandling; VAS; Nursing; Omvårdnad

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Haglund, B. (2018). Intranasal smärtlindring med sufentanil i en prehospital kontext : en kvantitativ studie. (Thesis). Sophiahemmet University. Retrieved from http://urn.kb.se/resolve?urn=urn:nbn:se:shh:diva-2980

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Haglund, Björn. “Intranasal smärtlindring med sufentanil i en prehospital kontext : en kvantitativ studie.” 2018. Thesis, Sophiahemmet University. Accessed January 23, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:shh:diva-2980.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Haglund, Björn. “Intranasal smärtlindring med sufentanil i en prehospital kontext : en kvantitativ studie.” 2018. Web. 23 Jan 2021.

Vancouver:

Haglund B. Intranasal smärtlindring med sufentanil i en prehospital kontext : en kvantitativ studie. [Internet] [Thesis]. Sophiahemmet University; 2018. [cited 2021 Jan 23]. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:shh:diva-2980.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Haglund B. Intranasal smärtlindring med sufentanil i en prehospital kontext : en kvantitativ studie. [Thesis]. Sophiahemmet University; 2018. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:shh:diva-2980

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

13. Fangous, Marie-Sarah. Nouvelle thérapeutique anti-Pseudomonas aeruginosa dans la mucoviscidose : les Lactobacillus spp. : New anti-Pseudomonas aeruginosa therapy for cystic fibrosis patients : the use of Lactobacillus spp.

Degree: Docteur es, Microbiologie, virologie et parasitologie, 2019, Brest

URL: http://www.theses.fr/2019BRES0056

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L’augmentation préoccupante de la résistance aux antibiotiques de Pseudomonas aeruginosa (PA) nécessite la recherche de thérapies alternatives telles que les Lactobacillus. Dans cette thèse, différents… (more)

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L’augmentation préoccupante de la résistance aux antibiotiques de Pseudomonas aeruginosa (PA) nécessite la recherche de thérapies alternatives telles que les Lactobacillus. Dans cette thèse, différents travaux ont été réalisés :1) Sur un modèle murin de pneumonie aigüe à PA, nous avons démontré l’effet bénéfique de l’administration intratrachéale d’un mélange de 3 souches de Lactobacillus provenant de lait ou de la cavité orale de patients sains.2) Nous avons ensuite prospectivement étudié la population en Lactobacillus des expectorations de patients atteints de mucoviscidose (CF). La prévalence moyenne de portage était de 61%.3) Parmi ces Lactobacillus issus de l’écosystème respiratoire des patients CF, nous avons constitué deux mélanges de 3 souches de Lactobacillus, sélectionnées pour leur activité anti-élastolytique et antipyocyanine in vitro. L’administration intranasale de ces mélanges à des souris C57Bl/6, 18h avant leur infection par PAO1, améliore significativement la survie à 7 jours des souris, ainsi que la clairance pulmonaire en PAO1 à 24h post-infection. Une diminution significative du recrutement pulmonaire des neutrophiles et des cytokines proinflammatoires était observée, associée à une augmentation de celle en IL-10.Ainsi, cette thèse démontre les effets bénéfiques de l’administration prophylactique des Lactobacillus par voie respiratoire sur la pneumonie aigue à PA. Ce résultat serait lié à l’immunomodulation de ces bactéries.Enfin, les propriétés contre l’élastase et la pyocyanine de ces souches in vitro ne présagent pas de leur activité in vivo, avec le mélange L. paracasei 9N, L. brevis 24C et L. salivarius 20C présentant seulement in vivo la meilleure activité (Brevet BIO17555).

The alarming increase in antibiotic resistance of Pseudomonas aeruginosa (PA) requires studying alternative therapies, such as Lactobacillus. In this thesis, several studies were carried out:1) In a murine model of acute PA pneumonia, we have demonstrated the beneficial effect of intratracheal administration of a mixture of three Lactobacillus strains from milk or the oral cavity of healthy patients.2) We then prospectively studied the Lactobacillus population in sputum of patients with cystic fibrosis (CF). The average prevalence of carry was 61%.3) Lactobacillus from the respiratory ecosystem of CF patients were used to establish two mixtures of 3 Lactobacillus strains. Strains were selected for their antielastolytic and anti-pyocyanin effects in vitro.Intranasal administration of these mixtures to C57Bl / 6 mice, 18h prior to PAO1 infection significantly improves 7-day survival and pulmonary clearance of PAO1 24h postinfection.A significant decrease in lung neutrophil recruitment and pro-inflammatory cytokines was observed, while the production of IL-10 increased.This thesis demonstrates the beneficial effects of prophylactic respiratory administration of Lactobacillus on acute PA pneumonia. Anti-PA properties in vitro are not an indication of the in vivo activity. The mixture containing L. paracasei 9N, L. brevis…

Advisors/Committee Members: Le Berre, Rozenn (thesis director).

Subjects/Keywords: Pneumonie; Souris; Intranasal; Pseudomonas; Lactobacillus; Probiotique; Pneumonia; Mice; Intranasal administration; Pseudomonas; Lactobacillus; Probiotics

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Fangous, M. (2019). Nouvelle thérapeutique anti-Pseudomonas aeruginosa dans la mucoviscidose : les Lactobacillus spp. : New anti-Pseudomonas aeruginosa therapy for cystic fibrosis patients : the use of Lactobacillus spp. (Doctoral Dissertation). Brest. Retrieved from http://www.theses.fr/2019BRES0056

Chicago Manual of Style (16^th Edition):

Fangous, Marie-Sarah. “Nouvelle thérapeutique anti-Pseudomonas aeruginosa dans la mucoviscidose : les Lactobacillus spp. : New anti-Pseudomonas aeruginosa therapy for cystic fibrosis patients : the use of Lactobacillus spp.” 2019. Doctoral Dissertation, Brest. Accessed January 23, 2021. http://www.theses.fr/2019BRES0056.

MLA Handbook (7^th Edition):

Fangous, Marie-Sarah. “Nouvelle thérapeutique anti-Pseudomonas aeruginosa dans la mucoviscidose : les Lactobacillus spp. : New anti-Pseudomonas aeruginosa therapy for cystic fibrosis patients : the use of Lactobacillus spp.” 2019. Web. 23 Jan 2021.

Vancouver:

Fangous M. Nouvelle thérapeutique anti-Pseudomonas aeruginosa dans la mucoviscidose : les Lactobacillus spp. : New anti-Pseudomonas aeruginosa therapy for cystic fibrosis patients : the use of Lactobacillus spp. [Internet] [Doctoral dissertation]. Brest; 2019. [cited 2021 Jan 23]. Available from: http://www.theses.fr/2019BRES0056.

Council of Science Editors:

Fangous M. Nouvelle thérapeutique anti-Pseudomonas aeruginosa dans la mucoviscidose : les Lactobacillus spp. : New anti-Pseudomonas aeruginosa therapy for cystic fibrosis patients : the use of Lactobacillus spp. [Doctoral Dissertation]. Brest; 2019. Available from: http://www.theses.fr/2019BRES0056

14. Braun, Ivan Mario. Potencial de abuso do midazolam intranasal em usuários de cocaína aspirada e voluntários normais.

Degree: PhD, Psiquiatria, 2012, University of São Paulo

URL: http://www.teses.usp.br/teses/disponiveis/5/5142/tde-28112012-124456/ ;

► INTRODUÇÃO: O midazolam é uma imidazobenzodiazepina usada para induzir o sono, produzir sedação antes de procedimentos dolorosos e no tratamento do estado de mal epiléptico.… (more)

▼ INTRODUÇÃO: O midazolam é uma imidazobenzodiazepina usada para induzir o sono, produzir sedação antes de procedimentos dolorosos e no tratamento do estado de mal epiléptico. Seu uso pela via intranasal proporciona um rápido início de ação e esta via, em muitos casos, pode substituir as vias endovenosa e intramuscular, mais invasivas. Assim, o midazolam intranasal tem sido sugerido no tratamento extra-hospitalar de crises epilépticas e ataques de pânico. Por outro lado, os benzodiazepínicos possuem um potencial para serem abusados, principalmente em usuários de outras drogas. OBJETIVO: o presente estudo objetivou verificar o potencial de abuso do midazolam intranasal numa população experiente no uso intranasal de substâncias - abusadores de cocaína aspirada. MÉTODOS: Foram estudados 31 voluntários abusadores ou dependentes de cocaína e 34 controles saudáveis, subdivididos em quatro grupos: Abusadores de Cocaína (N = 16) e Voluntários Saudáveis (N= 17) que receberam midazolam (0,5 mg de hidrocloreto de midazolam em cada narina), e Abusadores de Cocaína (N = 15) e Voluntários Saudáveis (N = 17) que receberam o mesmo volume de um placebo ativo. As variáveis de resposta foram a Apreciação da Substância (AS) e a Vontade de Repetir o Uso da Substância (VR), avaliadas através de escalas analógicas visuais. RESULTADOS: A análise de perfis para medidas repetidas das variáveis de resposta mostrou um efeito significante da variável Tempo sobre AS (F[5;57] =3,947, p=0,004) e VR (F[5;57] =3,311, p=0,011). A variável Grupo (Abusadores de Cocaína x Voluntários Saudáveis) também teve um impacto sobre as variáveis de resposta AS e VR, sendo que os Abusadores de Cocaína tiveram pontuações mais altas tanto em AS (F[5;57] = 4,946, p = 0,030) quanto em VR (F[5;57] =5,229, p=0,026). Numa análise de regressão linear para investigar os efeitos do humor - medidos através de uma Escala Visual Analógica do Humor (VAMS) - sobre as variáveis de resposta AS e VR, os Abusadores de Cocaína apresentaram escores maiores que os Voluntários saudáveis tanto para AS (t = 3,37; p = 0,001) quanto para VR (t = 5,607; p = 0,011). Observou-se, também, um efeito dos fatores VAMS 16 (MAIS DEPRIMIDO MAIS EUFÓRICO; t = 4,28; p < 0,001) e VAMS 12 (MAIS EXCITADO MAIS RELAXADO; t = 2,66; p = 0,010), sobre a variável de resposta AS (R2 = 0,32): níveis maiores de euforia e relaxamento predisseram uma maior Apreciação da Substância instilada. O fator VAMS 16 (MAIS DEPRIMIDO MAIS EUFÓRICO) teve um efeito também sobre a variável de resposta VR (t = 3,65, p < 0,001; R2 =0,24): maior euforia predisse maior vontade de repetir o uso da substância. Finalmente, uma análise de regressão linear utilizando-se AS como variável explicativa e VR como variável de resposta resultou que quanto maior a apreciação positiva da substância, maior era a vontade de repetir seu uso (F = 108, 517; p < 0,001; R2 = 0,65). CONCLUSÕES: Corroborando estudos anteriores, observou-se que sensações como relaxamento e euforia correlacionam-se com o potencial de abuso de uma substância e uma maior… Advisors/Committee Members: Bernik, Marcio Antonini.

Subjects/Keywords: Administração intranasal de medicamentos; Administration intranasal; Benzodiazepinas/farmacologia; Benzodiazepinas/uso terapêutico; Benzodiazepines/ therapeutic use; Benzodiazepines/pharmacology; Midazolam; Midazolam

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Braun, I. M. (2012). Potencial de abuso do midazolam intranasal em usuários de cocaína aspirada e voluntários normais. (Doctoral Dissertation). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/5/5142/tde-28112012-124456/ ;

Chicago Manual of Style (16^th Edition):

Braun, Ivan Mario. “Potencial de abuso do midazolam intranasal em usuários de cocaína aspirada e voluntários normais.” 2012. Doctoral Dissertation, University of São Paulo. Accessed January 23, 2021. http://www.teses.usp.br/teses/disponiveis/5/5142/tde-28112012-124456/ ;.

MLA Handbook (7^th Edition):

Braun, Ivan Mario. “Potencial de abuso do midazolam intranasal em usuários de cocaína aspirada e voluntários normais.” 2012. Web. 23 Jan 2021.

Vancouver:

Braun IM. Potencial de abuso do midazolam intranasal em usuários de cocaína aspirada e voluntários normais. [Internet] [Doctoral dissertation]. University of São Paulo; 2012. [cited 2021 Jan 23]. Available from: http://www.teses.usp.br/teses/disponiveis/5/5142/tde-28112012-124456/ ;.

Council of Science Editors:

Braun IM. Potencial de abuso do midazolam intranasal em usuários de cocaína aspirada e voluntários normais. [Doctoral Dissertation]. University of São Paulo; 2012. Available from: http://www.teses.usp.br/teses/disponiveis/5/5142/tde-28112012-124456/ ;

15. Nascimento, Laura de Oliveira. Porinas e suas ações imunomoduladoras dependentes de TLR2.

Degree: PhD, Tecnologia Químico-Farmacêutica, 2011, University of São Paulo

URL: http://www.teses.usp.br/teses/disponiveis/9/9135/tde-21032013-125043/ ;

► Os micro-organismos podem infectar seu hospedeiro por diferentes vias, sendo a principal o trato respiratório. O reconhecimento pela mucosa dessas vias pode desencadear inibição da… (more)

▼ Os micro-organismos podem infectar seu hospedeiro por diferentes vias, sendo a principal o trato respiratório. O reconhecimento pela mucosa dessas vias pode desencadear inibição da proliferação e bloqueio da entrada microbiana, assim como estimular resposta direcionada a memória imunológica para prevenir posteriores infecções. Alguns micro-organismo, como as bactérias Neisseria meningitidis e Neisseria lactamica, são capazes de modular a resposta imune de mucosa diretamente, ou por meio das células epiteliais respiratórias. Este trabalho propôs, então, a avaliação das porinas B provenientes destas bactérias como moduladoras da produção de IL-8 nas linhagens BEAS-2B e Detroit 562. Também foi avaliada a dependência deste estímulo ao receptor TLR2. Ambas as porinas se ligaram a TLR2 e por este receptor estimularam a produção de IL-8. O perfil de produção foi dependente da expressão de TLR2 pelas células. A porina lactâmica induziu menos IL-8 por regular negativamente a expressão de TLR2, mas sua afinidade pelo receptor se mostrou maior que a da porina meningocócica. As porinas são então moduladoras das células de mucosa, fato que somado a atividade adjuvante destas proteínas por via parenteral estimulou a avaliação destas como adjuvantes de mucosa. O modelo escolhido para a avaliação foi o de inoculação intranasal de camundongos, utilizando como antígeno o lipopolissacarídio pouco imunogênico de Franciscella tularensis atenuada (Ft-LPS). A análise foi baseada no título de anticorpos IgG e IgM séricos. A porina meningocócica se mostrou a mais imunogênica, mas por ser originária de patógeno acarreta maior risco biológico em sua produção. Para viabilizar a porina meningocócica como adjuvante, a mesma foi substituída por porina homóloga produzida de modo recombinante em Escherichia coli não patogênica. A porina recombinante foi avaliada pelo mesmo sistema in vivo e comparada a adjuvantes experimentais de ação conhecida (rCTB, QS-21 e ODN 1826). A porina apresentou o melhor desempenho entre todos os adjuvantes, principalmente dois meses após o fim do esquema vacinal. O mesmo adjuvante foi adicionado ao vírus da raiva para caracterizar a amplitude de antígenos para sua aplicação e o efeito biológico dos anticorpos induzidos. Os resultados obtidos por via intranasal com antígeno da raiva confirmaram a propriedade de adjuvante de mucosa da porina recombinante, aumentando os títulos de IgG séricos. O ensaio biológico dos anticorpos por RFFIT comprovaram a funcionalidade dos anticorpos gerados, neutralizando a infectividade viral em células BHK-21. O uso da porina por via subcutânea não aumentou o nível de anticorpos neutralizantes, mas aumentou o de IgG. Não foi detectada imunidade celular específica de linfócitos do baço ao vírus da raiva nos parâmetros avaliados, independente da adição de adjuvantes. Em resumo, as porinas foram caracterizadas como relevantes na imunomodulação de células da mucosa respiratória por infecção meningocócica. A modulação também foi relevante para o aumento de resposta humoral frente a diferentes… Advisors/Committee Members: Pessoa Junior, Adalberto, Stephano, Marco Antonio.

Subjects/Keywords: Adjuvant; Adjuvante; IL-8; IL-8; Intranasal vaccination; Porin; Porina; Rabies virus; TLR2; TLR2; Vacinação intranasal; Vírus da raiva

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Nascimento, L. d. O. (2011). Porinas e suas ações imunomoduladoras dependentes de TLR2. (Doctoral Dissertation). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/9/9135/tde-21032013-125043/ ;

Chicago Manual of Style (16^th Edition):

Nascimento, Laura de Oliveira. “Porinas e suas ações imunomoduladoras dependentes de TLR2.” 2011. Doctoral Dissertation, University of São Paulo. Accessed January 23, 2021. http://www.teses.usp.br/teses/disponiveis/9/9135/tde-21032013-125043/ ;.

MLA Handbook (7^th Edition):

Nascimento, Laura de Oliveira. “Porinas e suas ações imunomoduladoras dependentes de TLR2.” 2011. Web. 23 Jan 2021.

Vancouver:

Nascimento LdO. Porinas e suas ações imunomoduladoras dependentes de TLR2. [Internet] [Doctoral dissertation]. University of São Paulo; 2011. [cited 2021 Jan 23]. Available from: http://www.teses.usp.br/teses/disponiveis/9/9135/tde-21032013-125043/ ;.

Council of Science Editors:

Nascimento LdO. Porinas e suas ações imunomoduladoras dependentes de TLR2. [Doctoral Dissertation]. University of São Paulo; 2011. Available from: http://www.teses.usp.br/teses/disponiveis/9/9135/tde-21032013-125043/ ;

16. Mekitarian Filho, Eduardo. Utilização do midazolam intranasal como sedativo para tomografia em crianças.

Degree: PhD, Pediatria, 2013, University of São Paulo

URL: http://www.teses.usp.br/teses/disponiveis/5/5141/tde-20052013-154238/ ;

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Objetivos: Avaliar a segurança e a eficácia do midazolam intranasal (MIN) para sedação para tomografia em crianças, bem como a qualidade dos estudos radiológicos obtidos… (more)

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Objetivos: Avaliar a segurança e a eficácia do midazolam intranasal (MIN) para sedação para tomografia em crianças, bem como a qualidade dos estudos radiológicos obtidos com esta técnica. Material e métodos: Entre dezembro de 2011 e julho de 2012, este estudo prospectivo avaliou o MIN como sedativo para crianças submetidas à tomografia sem acesso venoso. Após aprovação do Comitê de Ética em Pesquisa e consentimento dos responsáveis, 0,4 mg/kg de MIN foi administrado, sendo feita dose adicional de 0,1 mg/kg se o nível de sedação avaliado pela Escala de Sedação de Ramsay não fosse atingida após 15 minutos da primeira dose. Os desfechos relacionados à sedação incluíram tempo para sedação e para atingir os critérios de alta; parâmetros fisiológicos como oximetria de pulso e frequência cardíaca foram registrados a cada cinco minutos até a alta. A qualidade dos exames tomográficos foi avaliada quanto à presença de artefatos de imagem e movimento. Resultados: 60 eventos de sedação foram realizados em 58 pacientes. A idade média foi de 15,5 meses, sendo 90,9% dos exames tomográficos de crânio. O tempo médio para sedação foi de 15,2 minutos (5-40) e o tempo médio para atingir os critérios de alta foi de 74,7 minutos. Eventos adversos foram observados em 5 crianças (8,4%), incluindo reação paradoxal (3), tempo de recuperação prolongado (1) e vômitos (1). Apenas 4 pacientes (6,7%) não foram adequadamente sedados com MIN. Imagens consideradas excelentes, sem artefatos, foram obtidas em 56 (93,3%) sedações. Não houve eventos como bradicardia, hipoxemia ou hipotensão. Conclusões: O midazolam intranasal, administrado via atomizador nasal, é um método simples e não-invasivo para sedação segura, eficaz e previsível para crianças na obtenção de estudos tomográficos de qualidade

Objective: To evaluate the safety, efficacy and image quality of sedation with aerosolized intranasal midazolam for pediatric CT studies. Materials and Methods: Between December 2011 to May 2012, this prospective study evaluated aerosolized intranasal (AIN) midazolam as a sedative for CT of children without intravenous access. After IRB approval and parental consent, 0,4 mg/kg of AIN midazolam was administered, and repeated with 0.1 mg/kg if adequate sedation evaluated by Ramsay Sedation Scale not achieved in 15 minutes after the first dose. Sedation outcome variables which included time to achieve sedation, to meet discharge criteria and physiological vital signs of pulse oximetry and heart rate, were recorded every five minutes until discharge. The quality of CT images was reviewed and graded for presence of motion and imaging artifacts, Results: 60 sedation encounters were performed in 58 children. Mean age was 15.5 months, and 90.9% of CT scans were brain scans. Mean time to sedation was 15.2 minutes (range 5-40) and mean time to achieve discharge criteria was 74.7 minutes. Adverse events were recorded in 5 children (8.4%) that underwent sedation - paradoxical reaction (3), prolonged recovery time (1) and vomiting (1). Only 4 patients (6.7%) failed to…

Advisors/Committee Members: Carvalho, Werther Brunow de.

Subjects/Keywords: Administração intranasal; Computerized tomography; Conscious sedation/ adverse effects; Intranasal administration; Midazolam; Midazolam; Pediatria; Pediatrics; Sedação consciente/ efeitos adversos; Tomografia computadorizada

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Mekitarian Filho, E. (2013). Utilização do midazolam intranasal como sedativo para tomografia em crianças. (Doctoral Dissertation). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/5/5141/tde-20052013-154238/ ;

Chicago Manual of Style (16^th Edition):

Mekitarian Filho, Eduardo. “Utilização do midazolam intranasal como sedativo para tomografia em crianças.” 2013. Doctoral Dissertation, University of São Paulo. Accessed January 23, 2021. http://www.teses.usp.br/teses/disponiveis/5/5141/tde-20052013-154238/ ;.

MLA Handbook (7^th Edition):

Mekitarian Filho, Eduardo. “Utilização do midazolam intranasal como sedativo para tomografia em crianças.” 2013. Web. 23 Jan 2021.

Vancouver:

Mekitarian Filho E. Utilização do midazolam intranasal como sedativo para tomografia em crianças. [Internet] [Doctoral dissertation]. University of São Paulo; 2013. [cited 2021 Jan 23]. Available from: http://www.teses.usp.br/teses/disponiveis/5/5141/tde-20052013-154238/ ;.

Council of Science Editors:

Mekitarian Filho E. Utilização do midazolam intranasal como sedativo para tomografia em crianças. [Doctoral Dissertation]. University of São Paulo; 2013. Available from: http://www.teses.usp.br/teses/disponiveis/5/5141/tde-20052013-154238/ ;

17. Pereau Buffin, Sophie. Évaluation des pseudo-particules grippales dans un but de vaccination par voies muqueuses : Evaluation of influenza virus-like-particles for mucosal vaccination.

Degree: Docteur es, Immunologie et vaccinologie, 2019, Lyon

URL: http://www.theses.fr/2019LYSE1087

►

Le virus de la grippe infecte les muqueuses du tractus respiratoire. Un vaccin intranasal induit une réponse immunitaire proche de celle faisant suite à une… (more)

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Le virus de la grippe infecte les muqueuses du tractus respiratoire. Un vaccin intranasal induit une réponse immunitaire proche de celle faisant suite à une infection naturelle en bloquant le virus directement sur le site de l'infection et permet une vaccination sans aiguille. Par ailleurs, les vaccins à base de pseudo-particules virales ou Virus-like Particles (VLP) produites sur cellules représentent une alternative intéressante au vaccin classique produit sur oeufs. Les VLP sont des particules non-réplicatives qui ressemblent au virus et qui peuvent être immunogènes même sans adjuvant, en particulier par voie intranasale. Au cours de ma thèse, une plateforme de production de VLP grippales composées d'hémagglutinine, de neuraminidase et de protéine de matrice M1 a été développée par transfection transitoire des cellules de mammifères. Des immunisations de souris BALB/c ont montré que les VLP de type A et B, purifiées et caractérisées, étaient immunogènes à de faibles doses par voie intramusculaire. L'administration par voie intranasale de VLP avec la sous-unité B de la toxine cholérique, comme adjuvant muqueux, a permis d'obtenir des taux d'anticorps sériques comparables à ceux obtenus par immunisation en intramusculaire mais également une forte réponse IgA au niveau des muqueuses. Par ailleurs, le rendement des VLP s'est révélé souche-dépendant et lié aux protéines HA et NA à la surface de la particule. Pour contourner ce problème, un vaccin quadrivalent composé de deux VLP bivalentes exprimant chacune deux HA et NA différentes à la surface a été produit montrant ainsi la flexibilité de cette plateforme

The influenza virus infects the mucous membranes of the respiratory tract. An intranasal vaccine induces an immune response close to the one induced by the natural infection by blocking the virus directly at the site of infection and allows needle-free vaccination. In addition, vaccines based on Virus-like Particles (VLP) produced in cells represent an interesting alternative to the traditional egg-based vaccine. VLPs are non-replicative particles that mimic the virus. Studies on influenza VLPs have shown protection by the intranasal route without adding an adjuvant. During my thesis, a platform for the production of influenza VLPs composed of the hemagglutinin, the neuraminidase and the M1 matrix proteins was developed by transient transfection of mammalian cells. Immunizations of BALB/c mice showed that the purified and characterized type A and B VLPs were immunogenic at low doses by the intramuscular route. The intranasal administration of VLPs with the B subunit of cholera toxin as a mucosal adjuvant resulted in serum antibody levels comparable to those obtained by intramuscular immunization but also a strong IgA response in the mucosal secretions. In addition, VLP yield was found to be strain-dependent and linked to the HA and NA proteins on the surface of the particle. To overcome this problem, a quadrivalent vaccine based on two bivalent VLPs each expressing two different HAs and NAs at the surface was…

Advisors/Committee Members: Legastelois, Isabelle (thesis director).

Subjects/Keywords: Influenza; Pseudo-particule virale; Vaccin muqueux; Intranasal; Sublingual; Influenza; Virus-like particle; Mucosal vaccine; Intranasal; Sublingual; 570

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Pereau Buffin, S. (2019). Évaluation des pseudo-particules grippales dans un but de vaccination par voies muqueuses : Evaluation of influenza virus-like-particles for mucosal vaccination. (Doctoral Dissertation). Lyon. Retrieved from http://www.theses.fr/2019LYSE1087

Chicago Manual of Style (16^th Edition):

Pereau Buffin, Sophie. “Évaluation des pseudo-particules grippales dans un but de vaccination par voies muqueuses : Evaluation of influenza virus-like-particles for mucosal vaccination.” 2019. Doctoral Dissertation, Lyon. Accessed January 23, 2021. http://www.theses.fr/2019LYSE1087.

MLA Handbook (7^th Edition):

Pereau Buffin, Sophie. “Évaluation des pseudo-particules grippales dans un but de vaccination par voies muqueuses : Evaluation of influenza virus-like-particles for mucosal vaccination.” 2019. Web. 23 Jan 2021.

Vancouver:

Pereau Buffin S. Évaluation des pseudo-particules grippales dans un but de vaccination par voies muqueuses : Evaluation of influenza virus-like-particles for mucosal vaccination. [Internet] [Doctoral dissertation]. Lyon; 2019. [cited 2021 Jan 23]. Available from: http://www.theses.fr/2019LYSE1087.

Council of Science Editors:

Pereau Buffin S. Évaluation des pseudo-particules grippales dans un but de vaccination par voies muqueuses : Evaluation of influenza virus-like-particles for mucosal vaccination. [Doctoral Dissertation]. Lyon; 2019. Available from: http://www.theses.fr/2019LYSE1087

Uppsala University

18. Ahlqvist, Anna Emanuelsson. Nasal smärtbehandling av barn med akuta smärttillstånd inom akutsjukvård och prehospitalt.

Degree: Public Health and Caring Sciences, 2010, Uppsala University

URL: http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-126387

► The aim of thie literature review was to study the advantages and disadventages of the intranasal medication, treating children with acute pain in prehsopital… (more)

Subjects/Keywords: intranasal; children; pain; prehospital; intranasal; barn; smärta; prehospital

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APA (6^th Edition):

Ahlqvist, A. E. (2010). Nasal smärtbehandling av barn med akuta smärttillstånd inom akutsjukvård och prehospitalt. (Thesis). Uppsala University. Retrieved from http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-126387

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Ahlqvist, Anna Emanuelsson. “Nasal smärtbehandling av barn med akuta smärttillstånd inom akutsjukvård och prehospitalt.” 2010. Thesis, Uppsala University. Accessed January 23, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-126387.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Ahlqvist, Anna Emanuelsson. “Nasal smärtbehandling av barn med akuta smärttillstånd inom akutsjukvård och prehospitalt.” 2010. Web. 23 Jan 2021.

Vancouver:

Ahlqvist AE. Nasal smärtbehandling av barn med akuta smärttillstånd inom akutsjukvård och prehospitalt. [Internet] [Thesis]. Uppsala University; 2010. [cited 2021 Jan 23]. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-126387.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Ahlqvist AE. Nasal smärtbehandling av barn med akuta smärttillstånd inom akutsjukvård och prehospitalt. [Thesis]. Uppsala University; 2010. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-126387

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universidade do Rio Grande do Sul

19. Dalberto, Tiago Pires. Avaliação da transferência gênica pela via nasal para o sistema nervoso central utilizando um vetor não viral.

Degree: 2007, Universidade do Rio Grande do Sul

URL: http://hdl.handle.net/10183/13837

►

O estudo de metodologias que possibilitem o acesso de moléculas terapêuticas ao cérebro evitando a barreira hematoencefálica (blood-brain barrier, BBB), é extremamente importante para o… (more)

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O estudo de metodologias que possibilitem o acesso de moléculas terapêuticas ao cérebro evitando a barreira hematoencefálica (blood-brain barrier, BBB), é extremamente importante para o tratamento das doenças que afetam o sistema nervoso central. Os estudos se concentram na busca por vias seguras e pouco invasivas. Recentemente a via nasal tem mostrado resultados positivos na administração de fármacos ao sistema nervoso central de maneira segura, sugerindo a utilização desta via para a terapia gênica. Neste trabalho, foi estudada a administração intranasal de um vetor não viral, que codifica o gene da proteína verde fluorescente otimizada (enhanced green fluorescent proten, EGFP), diluído em água ou em solução de sulfato de zinco em camundongos adultos da linhagem BALB/c. Os resultados de RT-PCR mostraram que o vetor atingiu o cérebro em ambos tratamentos, e sua expressão foi mantida até 8 semanas após o tratamento. A expressão da EGPF em diferentes regiões cerebrais foi analisada 1, 2, 4 e 8 semanas após o tratamento, através de imunohistoquímica. Nossos resultados mostraram que um número muito pequeno de células foi transfectado em ambos tratamentos e que a freqüência destas células nas regiões cerebrais estudadas varia muito mesmo entre animais do mesmo grupo. O tratamento com sulfato de zinco não aumentou a eficiência do vetor. Os maiores números de células transfectadas encontradas foram no bulbo olfatório e hipocampos uma semana após o tratamento. Nossos resultados mostram pela primeira vez a expressão prolongada de um gene administrados pela via nasal no cérebro.

The investigation of methods that allow the access of therapeutic molecules to the brain, overcoming the blood-brain barrier (BBB), is of great importance for the treatment of diseases reaching the central nervous system. Studies concentrate mainly on the search for safer and less aggressive routes. Recent studies have suggested that pharmaceutical agents can reach the brain by the nasal route, that may thus be also appropriate for gene therapy. Here, we investigated brain targeting by intranasal administration of a plasmid vector (pREGFP) with the reporter gene EGFP, diluted in water or in a zinc sulfate/water solution, to adult BALB/c mice. Brain regions were examined by RT-PCR or immunohistochemistry 1, 2, 4 or 8 weeks after the treatment. RT-PCR results showed that the plasmid DNA reached the brain similarly with the two types of treatment. Expression of egfp was observed in all groups, and maintained even 8 weeks after treatment. Brain sections submitted to immunohistochemistry (IHC) were analyzed for the detection of EGFP-positive cells, that could be observed in brain samples from mice treated by intranasal administration of pREGFP. The frequency of EGFP-positive cells was very low, and presented great variation even among mice from the same experimental group. The supplementation of the transfection medium with zinc sulfate did not induce higher numbers of EGFP-positive cells. A higher frequency of these cells was observed in the…

Advisors/Committee Members: Nardi, Nance Beyer.

Subjects/Keywords: Terapia gênica; Transferência genética; Administração intranasal; Sistema nervoso central; Camundongos

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APA (6^th Edition):

Dalberto, T. P. (2007). Avaliação da transferência gênica pela via nasal para o sistema nervoso central utilizando um vetor não viral. (Thesis). Universidade do Rio Grande do Sul. Retrieved from http://hdl.handle.net/10183/13837

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Dalberto, Tiago Pires. “Avaliação da transferência gênica pela via nasal para o sistema nervoso central utilizando um vetor não viral.” 2007. Thesis, Universidade do Rio Grande do Sul. Accessed January 23, 2021. http://hdl.handle.net/10183/13837.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Dalberto, Tiago Pires. “Avaliação da transferência gênica pela via nasal para o sistema nervoso central utilizando um vetor não viral.” 2007. Web. 23 Jan 2021.

Vancouver:

Dalberto TP. Avaliação da transferência gênica pela via nasal para o sistema nervoso central utilizando um vetor não viral. [Internet] [Thesis]. Universidade do Rio Grande do Sul; 2007. [cited 2021 Jan 23]. Available from: http://hdl.handle.net/10183/13837.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Dalberto TP. Avaliação da transferência gênica pela via nasal para o sistema nervoso central utilizando um vetor não viral. [Thesis]. Universidade do Rio Grande do Sul; 2007. Available from: http://hdl.handle.net/10183/13837

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universiteit Utrecht

20. Zon, A.P. van der. Antibody response to POMP90-3 after intranasal infection in sheep with Chlamydophila abortus.

Degree: 2008, Universiteit Utrecht

URL: http://dspace.library.uu.nl:8080/handle/1874/34003

► Ovine enzootic abortion (OEA), caused by infection with gram negative bacteria Chlamydophila abortus (C. abortus), is one of the major causes of infectious abortion in… (more)

Subjects/Keywords: Diergeneeskunde; Chlamydophila abortus, intranasal infection, POMP90, POMP90-3, antibody response

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APA (6^th Edition):

Zon, A. P. v. d. (2008). Antibody response to POMP90-3 after intranasal infection in sheep with Chlamydophila abortus. (Doctoral Dissertation). Universiteit Utrecht. Retrieved from http://dspace.library.uu.nl:8080/handle/1874/34003

Chicago Manual of Style (16^th Edition):

Zon, A P van der. “Antibody response to POMP90-3 after intranasal infection in sheep with Chlamydophila abortus.” 2008. Doctoral Dissertation, Universiteit Utrecht. Accessed January 23, 2021. http://dspace.library.uu.nl:8080/handle/1874/34003.

MLA Handbook (7^th Edition):

Zon, A P van der. “Antibody response to POMP90-3 after intranasal infection in sheep with Chlamydophila abortus.” 2008. Web. 23 Jan 2021.

Vancouver:

Zon APvd. Antibody response to POMP90-3 after intranasal infection in sheep with Chlamydophila abortus. [Internet] [Doctoral dissertation]. Universiteit Utrecht; 2008. [cited 2021 Jan 23]. Available from: http://dspace.library.uu.nl:8080/handle/1874/34003.

Council of Science Editors:

Zon APvd. Antibody response to POMP90-3 after intranasal infection in sheep with Chlamydophila abortus. [Doctoral Dissertation]. Universiteit Utrecht; 2008. Available from: http://dspace.library.uu.nl:8080/handle/1874/34003

University of Toronto

21. Cha, Danielle Soh-Young. A Randomized, Double-Blind, Placebo-Controlled, Crossover Trial Evaluating the Effect of Intranasal Insulin on Cognition and Emotional Processing in Individuals with Treatment-Resistant Major Depressive Disorder.

Degree: 2016, University of Toronto

URL: http://hdl.handle.net/1807/71672

►

Aim: Available evidence indicates that individuals with major depressive disorder (MDD) differentially respond to emotionally valenced information alongside impairments in cognition; however, the exact underlying… (more)

Subjects/Keywords: Cognition; Emotion; Intranasal Insulin; Major Depressive Disorder; Treatment Resistance; 0347

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APA (6^th Edition):

Cha, D. S. (2016). A Randomized, Double-Blind, Placebo-Controlled, Crossover Trial Evaluating the Effect of Intranasal Insulin on Cognition and Emotional Processing in Individuals with Treatment-Resistant Major Depressive Disorder. (Masters Thesis). University of Toronto. Retrieved from http://hdl.handle.net/1807/71672

Chicago Manual of Style (16^th Edition):

Cha, Danielle Soh-Young. “A Randomized, Double-Blind, Placebo-Controlled, Crossover Trial Evaluating the Effect of Intranasal Insulin on Cognition and Emotional Processing in Individuals with Treatment-Resistant Major Depressive Disorder.” 2016. Masters Thesis, University of Toronto. Accessed January 23, 2021. http://hdl.handle.net/1807/71672.

MLA Handbook (7^th Edition):

Cha, Danielle Soh-Young. “A Randomized, Double-Blind, Placebo-Controlled, Crossover Trial Evaluating the Effect of Intranasal Insulin on Cognition and Emotional Processing in Individuals with Treatment-Resistant Major Depressive Disorder.” 2016. Web. 23 Jan 2021.

Vancouver:

Cha DS. A Randomized, Double-Blind, Placebo-Controlled, Crossover Trial Evaluating the Effect of Intranasal Insulin on Cognition and Emotional Processing in Individuals with Treatment-Resistant Major Depressive Disorder. [Internet] [Masters thesis]. University of Toronto; 2016. [cited 2021 Jan 23]. Available from: http://hdl.handle.net/1807/71672.

Council of Science Editors:

Cha DS. A Randomized, Double-Blind, Placebo-Controlled, Crossover Trial Evaluating the Effect of Intranasal Insulin on Cognition and Emotional Processing in Individuals with Treatment-Resistant Major Depressive Disorder. [Masters Thesis]. University of Toronto; 2016. Available from: http://hdl.handle.net/1807/71672

University of Delaware

22. Chakraborty, Trisha. Tracking effects of oxytocin crossing the blood brain barrier in vivo and in vitro.

Degree: PhD, University of Delaware, Department of Psychological and Brain Sciences, 2017, University of Delaware

URL: http://udspace.udel.edu/handle/19716/23027

► Oxytocin is widely used in clinical trials to treat diseases that manifest from central nervous system dysfunction. Peripheral administration of oxytocin- both subcutaneous and intranasal-… (more)

▼ Oxytocin is widely used in clinical trials to treat diseases that manifest from central nervous system dysfunction. Peripheral administration of oxytocin- both subcutaneous and intranasal- have efficacious effects on symptoms of autism, schizophrenia, PTSD, and anxiety. The behavioral outcomes of oxytocin treatment are assumed to derive from central effects in the brain. However, how oxytocin crosses into brain through the blood brain barrier to alter central nervous system function is not well understood. In addition, little is known about the cellular mechanisms by which exogenous oxytocin might modulate behavioral outcomes. This dissertation examines the role of exogenous oxytocin in modulating brain activity and behavior. The first aim of this dissertation is to determine whether oxytocin crosses through the blood brain barrier. To that effect, varying doses of oxytocin are applied to the luminal side of an artificial blood brain. Oxytocin that crosses to the luminal side is assayed with an ELISA. The second aim of this dissertation is to determine how oxytocin administered intranasally or subcutaneously changes plasma oxytocin concentration and gene expression in brain. Rats are dosed with varying doses of oxytocin intranasally or subcutaneously. After 30 minutes, plasma is extracted and oxytocin concentration is measured using an ELISA. Egr-1 gene expression in brain regions associated with oxytocin production, oxytocin receptor activity and oxytocin-mediated behavioral outcomes is assayed using in situ hybridization. The results of these studies indicate that higher doses of oxytocin cross an artificial blood brain barrier in higher concentrations than lower doses. These findings are used to develop a dose-response curve of oxytocin penetration of the blood brain barrier, which is then used to predict how oxytocin may cross the blood brain barrier in vivo. These results also demonstrate that higher doses of both intranasal and subcutaneous oxytocin administration increase plasma oxytocin concentration significantly above vehicle controls. Using the model developed in the previous aim, high doses of subcutaneous oxytocin are expected to penetrate the blood brain barrier. However, compared to subcutaneous administration, high doses of intranasal oxytocin cannot penetrate the blood brain barrier, although they too increase plasma oxytocin significantly above home cage controls. In brain, both subcutaneous and intranasal oxytocin alter Egr-1 gene expression. High intranasal and subcutaneous doses increase gene expression in the paraventricular nucleus of the hypothalamus and the central nucleus of the amygdala. A high subcutaneous dose also increases Egr-1 activity in the anterior division of the bed nucleus of the stria terminalis. Together, these findings suggest that oxytocin passes through the blood brain barrier and modulates brain activity through an Egr-1 mediated mechanism. Behavioral effects reported in other studies may be modulated by the changes in central nervous system activity reported here. These… Advisors/Committee Members: Rosen, Jeffrey B..

Subjects/Keywords: Biological sciences; Blood brain barrier; Egr-1; Intranasal; Oxytocin; Subcutaneous

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APA (6^th Edition):

Chakraborty, T. (2017). Tracking effects of oxytocin crossing the blood brain barrier in vivo and in vitro. (Doctoral Dissertation). University of Delaware. Retrieved from http://udspace.udel.edu/handle/19716/23027

Chicago Manual of Style (16^th Edition):

Chakraborty, Trisha. “Tracking effects of oxytocin crossing the blood brain barrier in vivo and in vitro.” 2017. Doctoral Dissertation, University of Delaware. Accessed January 23, 2021. http://udspace.udel.edu/handle/19716/23027.

MLA Handbook (7^th Edition):

Chakraborty, Trisha. “Tracking effects of oxytocin crossing the blood brain barrier in vivo and in vitro.” 2017. Web. 23 Jan 2021.

Vancouver:

Chakraborty T. Tracking effects of oxytocin crossing the blood brain barrier in vivo and in vitro. [Internet] [Doctoral dissertation]. University of Delaware; 2017. [cited 2021 Jan 23]. Available from: http://udspace.udel.edu/handle/19716/23027.

Council of Science Editors:

Chakraborty T. Tracking effects of oxytocin crossing the blood brain barrier in vivo and in vitro. [Doctoral Dissertation]. University of Delaware; 2017. Available from: http://udspace.udel.edu/handle/19716/23027

Northeastern University

23. Kadakia, Ekta. Experimental Investigation And Mathematical Modeling For Nanoemulsion-based Drug Delivery To The Central Nervous System (cns).

Degree: PhD, School of Pharmacy, 2018, Northeastern University

URL: http://hdl.handle.net/2047/D20316233

► Novel therapies for treating neurological diseases have resulted in limited success - not only because of the lack of pharmacological activity, but also due to… (more)

▼ Novel therapies for treating neurological diseases have resulted in limited success - not only because of the lack of pharmacological activity, but also due to the ineffective delivery of drugs into the brain. Nano-scale drug delivery system such as nanoemulsions have received significant attention for improving central nervous system (CNS) drug delivery. The objective of this doctoral thesis project was to investigate the transport mechanisms and CNS drug delivery potential of systemically and intranasally administered nanoemulsions. First - a hypothesis on sensitive formulation attributes to increase the cellular permeability of nanoemulsions was generated by modeling the cellular permeability data of fish oil nanoemulsions in Caco-2 cells. Next, rapamycin-containing fish oil nanoemulsions were dose systemically to mice, where the pharmacokinetic results suggested that the circulation half-life and particle size distribution did not impact the brain targeting efficiency of nanoemulsions, and in the absence of any improvement in the systemic exposures of rapamycin, nanoemulsions did not outperform their aqueous counterpart with respect to the extent of CNS drug delivery. Going forward, a semi-mechanistic model was developed to investigate the CNS targeting potential and transport mechanisms of intranasally administered nanoemulsions. Our work not only confirmed that nanoemulsions consistently resulted in enhanced CNS drug delivery and targeting efficiency than drug solutions, but also provided insights on their transport mechanisms. Our work established that following systemic dosing nanoemulsions do not provide a robust drug delivery approach to enhance brain targeting, and BBB penetration, which primarily depends on intrinsic drug-related properties, may not be significantly improved following encapsulation of drugs in nanoemulsions. However, the mathematical modeling and simulation results demonstrated that following intranasal dosing, nanoemulsions improve drug permeability and bioavailability in the nasal cavity to significantly enhance CNS drug delivery, thereby providing an effective delivery system for targeting drugs to the CNS.

Subjects/Keywords: Brain targeting; CNS; Intranasal; Nanoemulsions; Systemic; Pharmaceutical sciences

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APA (6^th Edition):

Kadakia, E. (2018). Experimental Investigation And Mathematical Modeling For Nanoemulsion-based Drug Delivery To The Central Nervous System (cns). (Doctoral Dissertation). Northeastern University. Retrieved from http://hdl.handle.net/2047/D20316233

Chicago Manual of Style (16^th Edition):

Kadakia, Ekta. “Experimental Investigation And Mathematical Modeling For Nanoemulsion-based Drug Delivery To The Central Nervous System (cns).” 2018. Doctoral Dissertation, Northeastern University. Accessed January 23, 2021. http://hdl.handle.net/2047/D20316233.

MLA Handbook (7^th Edition):

Kadakia, Ekta. “Experimental Investigation And Mathematical Modeling For Nanoemulsion-based Drug Delivery To The Central Nervous System (cns).” 2018. Web. 23 Jan 2021.

Vancouver:

Kadakia E. Experimental Investigation And Mathematical Modeling For Nanoemulsion-based Drug Delivery To The Central Nervous System (cns). [Internet] [Doctoral dissertation]. Northeastern University; 2018. [cited 2021 Jan 23]. Available from: http://hdl.handle.net/2047/D20316233.

Council of Science Editors:

Kadakia E. Experimental Investigation And Mathematical Modeling For Nanoemulsion-based Drug Delivery To The Central Nervous System (cns). [Doctoral Dissertation]. Northeastern University; 2018. Available from: http://hdl.handle.net/2047/D20316233

Northeastern University

24. Aly, Amirah Emad-Eldin. An intranasal GDNF gene therapy approach for treating Parkinson's disease.

Degree: PhD, School of Pharmacy, 2017, Northeastern University

URL: http://hdl.handle.net/2047/D20260243

► Parkinson's disease (PD) is a progressive neurodegenerative disorder that results from the loss of the A9 nigrostriatal dopamine neurons. The current therapies available for treating… (more)

▼ Parkinson's disease (PD) is a progressive neurodegenerative disorder that results from the loss of the A9 nigrostriatal dopamine neurons. The current therapies available for treating PD provide symptomatic relief by replacing or mimicking dopamine in the brain, but do not actually prevent or reverse the loss of these dopaminergic neurons. Glial cell-line derived neurotrophic factor (GDNF) has disease-modifying potential in PD due to its ability to promote the survival of dopamine neurons both in vitro and in vivo. GDNF has been shown to be neuroprotective in several animal models of PD. However, its clinical potential has been limited thus far by its inability to cross the blood-brain barrier (BBB) and the need for invasive intracranial delivery. The main objective of this thesis was to develop an approach to non-invasively deliver a continuous source of GDNF to the brain at levels that are neuroprotective in Parkinsons Disease, whilst minimizing systemic exposure. To do so, this project investigated the intranasal delivery of non-viral hGDNF expression plasmids (pGDNF_1b and pUGG) compacted into nanoparticles (NPs). Intranasal delivery allows large therapeutics to circumvent the BBB while avoiding peripheral exposure, while a gene therapy approach would provide a long-term renewable source of GDNF in the brain regions associated with PD. These NPs, developed by Copernicus Therapeutics, Inc., are composed of 10 kDa polyethylene glycol-substituted lysine 30-mers (CK30PEG10k) which unimolecularly compact the plasmid DNA into neutrally charged NPs.; The first goal of this project was to determine if intranasal administration of pGDNF_1b DNA NPs produces a neuroprotective and neurotrophic effect on rat substantia nigra (SN) dopamine neurons. The neuroprotective efficacy of this approach was tested in the rat unilateral 6-hydroxydopamine model of PD. Tyrosine hydroxylase (TH) immunostaining density was used as a marker for dopamine neurons in the SN and their nerve terminals in the striatum. Intranasal administration of pGDNF_1b NPs significantly reduced amphetamine-induced rotational behavior, increased TH staining density in both the SN and the striatum, and increased the number of TH-positive dopamine neurons in the SN. These results collectively demonstrated that pGDNF_1b was neuroprotective in this animal model of PD. The neurotrophic effect of pGDNF_1b was studied in the SN and striatum of healthy/intact rats, as well as in the unlesioned SN of 6-OHDA lesioned rats from the previous study. Intranasal pGDNF_1b NPs did not affect TH staining density in either the SN or the striatum of unlesioned rats, but it resulted in increases in TH staining density in the unlesioned SN of 6-OHDA lesioned rats relative to saline-or pGDNF_1b NP-treated unlesioned animals.; The next goals of this thesis were to examine the regional and cellular transfection and distribution pattern, as well as the time-course of transgene expression in the rat brain after intranasal delivery of pUGG NPs. Intranasal administration of pUGG NPs lead to…

Subjects/Keywords: focused ultrasound; GDNF; gene therapy; intranasal; nanoparticles; Parkinson's disease

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APA (6^th Edition):

Aly, A. E. (2017). An intranasal GDNF gene therapy approach for treating Parkinson's disease. (Doctoral Dissertation). Northeastern University. Retrieved from http://hdl.handle.net/2047/D20260243

Chicago Manual of Style (16^th Edition):

Aly, Amirah Emad-Eldin. “An intranasal GDNF gene therapy approach for treating Parkinson's disease.” 2017. Doctoral Dissertation, Northeastern University. Accessed January 23, 2021. http://hdl.handle.net/2047/D20260243.

MLA Handbook (7^th Edition):

Aly, Amirah Emad-Eldin. “An intranasal GDNF gene therapy approach for treating Parkinson's disease.” 2017. Web. 23 Jan 2021.

Vancouver:

Aly AE. An intranasal GDNF gene therapy approach for treating Parkinson's disease. [Internet] [Doctoral dissertation]. Northeastern University; 2017. [cited 2021 Jan 23]. Available from: http://hdl.handle.net/2047/D20260243.

Council of Science Editors:

Aly AE. An intranasal GDNF gene therapy approach for treating Parkinson's disease. [Doctoral Dissertation]. Northeastern University; 2017. Available from: http://hdl.handle.net/2047/D20260243

University of the Western Cape

25. Mahgoub, Ahmed Elsheikh Omer. The comparison of two doses of intranasal midazolam sedation in a paediatric dental emergency clinic .

Degree: 2011, University of the Western Cape

URL: http://hdl.handle.net/11394/3534

► The aim of the study was to compare two doses of intranasal midazolam (INM) 0.3 mg/kg and 0.5 mg/kg in terms of effectiveness and recovery… (more)

▼ The aim of the study was to compare two doses of intranasal midazolam (INM) 0.3 mg/kg and 0.5 mg/kg in terms of effectiveness and recovery time. Design:-This study was a Randomized Controlled Trial (RCT) and Triple blinded study. Sample and methods A sample of one hundred and eighteen children aged from 4-6 years old were randomly assigned for Intranasal sedation (INS) to either the 0.3 mg/kg group or the 0.5 mg/kg group. Children were taken in fasting and non-fasting conditions. The children were monitored using a pulse-oximeter, the sedation was assessed using Wilson sedation scale and the anxiety and behaviour scales were rated by Venham’s scale throughout the treatment. The facial image Scale (FIS) was also used to assess anxiety and mood of children before and after treatment. Results The mean BMI of children was found to be from 14-16. Intranasal sedation with both 0.3 mg/kg and 0.5 mg/kg midazolam was completed in 100% of the children. The pulse rates were within normal limit but statistically lower in the 0.5 mg/kg group. Oxygen saturation was above 98% in all except for one child who desaturated to 90%. Thirty five percent found this route acceptable in this study; Nine percent had burning sensation from midazolam. The state anxiety between the two groups of 0.3 mg/kg and 0.5 mg/kg were insignificant using Venham’s scale. However, behaviour scores showed statistical significant results of p value (0.03) and (0.04) in the behaviour during LA and behaviour during extractions respectively. The facial images scale (FIS) ratings chosen by the children before and after sedation was insignificant to the anxiety and behaviour ratings. The FIS revealed that 66% chose a happy face at the end of treatment. Fifty percent of the children in the study chose the same image before and after sedation. There were no adverse events encountered during the procedure. Conclusion INS with midazolam using the 0.3 mg/kg or 0.5 mg/kg doses resulted in safe and effective sedation. The 0.5 mg/kg proved to be more effective than the 0.3 mg/kg in providing better behaviour and decreasing anxiety when compared with the 0.3 mg/kg dose. The 0.5 mg/kg dose was found to be safe and the recovery time was slightly more than the 0.3 mg/kg but the difference was not clinically significant. Advisors/Committee Members: Peerbhay, Fathima (advisor), Roelofse, James (advisor).

Subjects/Keywords: Intranasal; Midazolam; Sedation; Comparison; Anxious; Paediatric; Children; Dental; Emergency; Clinic

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APA (6^th Edition):

Mahgoub, A. E. O. (2011). The comparison of two doses of intranasal midazolam sedation in a paediatric dental emergency clinic . (Thesis). University of the Western Cape. Retrieved from http://hdl.handle.net/11394/3534

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Mahgoub, Ahmed Elsheikh Omer. “The comparison of two doses of intranasal midazolam sedation in a paediatric dental emergency clinic .” 2011. Thesis, University of the Western Cape. Accessed January 23, 2021. http://hdl.handle.net/11394/3534.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Mahgoub, Ahmed Elsheikh Omer. “The comparison of two doses of intranasal midazolam sedation in a paediatric dental emergency clinic .” 2011. Web. 23 Jan 2021.

Vancouver:

Mahgoub AEO. The comparison of two doses of intranasal midazolam sedation in a paediatric dental emergency clinic . [Internet] [Thesis]. University of the Western Cape; 2011. [cited 2021 Jan 23]. Available from: http://hdl.handle.net/11394/3534.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Mahgoub AEO. The comparison of two doses of intranasal midazolam sedation in a paediatric dental emergency clinic . [Thesis]. University of the Western Cape; 2011. Available from: http://hdl.handle.net/11394/3534

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Sydney

26. Tan, Rachel. The Management of Allergic Rhinitis in the Community Pharmacy: A Real-Life Study of Current Practice in Australia .

Degree: 2019, University of Sydney

URL: http://hdl.handle.net/2123/21222

► Allergic rhinitis (AR) is a highly prevalent, chronic respiratory condition which results in significant personal and socioeconomic burdens on communities, that are of concern globally.… (more)

▼ Allergic rhinitis (AR) is a highly prevalent, chronic respiratory condition which results in significant personal and socioeconomic burdens on communities, that are of concern globally. These burdens are pronounced because people with AR often trivialise their condition and do not optimally manage their symptoms. This is of particular concern in people with co-morbid asthma, as asthma exacerbations are more pronounced particularly when AR control is poor. Considering AR is a manageable condition, it is imperative that we optimise management strategies to minimise the widespread burden caused by AR. This thesis aims to investigate the current AR management practices in the Australian community pharmacy setting in real time, in order to fully understand why AR is suboptimally managed and how it can be improved. Several research strategies were employed in this thesis. A researcher administered survey was carried out to explore pharmacy customer’s management of AR within the community pharmacy. This thesis showed the majority of the pharmacy customers are making suboptimal over the counter (OTC) medicines selections without consulting a pharmacist for recommendations or a general practitioner (GP) for a diagnosis. This is concerning as the majority experience moderate-severe symptoms yet only 15% of them selected the appropriate medication for the symptoms reported individually. This thesis also investigated the use of mobile health applications (mHealth apps) in the Australian Apple app store and Android Google Play Store, to address the specific tools used for patient’s AR self-management. Amongst the many apps evaluated in this thesis, Allergy Diary by MASK was identified to be effective in assisting patients in covering the multifaced AR self-management. It allowed patients to keep track of their symptoms daily, measure the severity of their symptoms, enhance their medication adherence and communication with their HCPs to manage their condition optimally. The findings in this thesis formed the basis for the development of an evidence-based clinical pathway, specific for the Australian community health care environment. It helps the AR health care community realise the problems associated with AR management and for best practice guidelines to be implemented in the community pharmacy.

Subjects/Keywords: Allergic Rhinitis; Asthma; Community Pharmacy; Intranasal Corticosteroids; Suboptimal Treatment; Pharmacist

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APA (6^th Edition):

Tan, R. (2019). The Management of Allergic Rhinitis in the Community Pharmacy: A Real-Life Study of Current Practice in Australia . (Thesis). University of Sydney. Retrieved from http://hdl.handle.net/2123/21222

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Tan, Rachel. “The Management of Allergic Rhinitis in the Community Pharmacy: A Real-Life Study of Current Practice in Australia .” 2019. Thesis, University of Sydney. Accessed January 23, 2021. http://hdl.handle.net/2123/21222.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Tan, Rachel. “The Management of Allergic Rhinitis in the Community Pharmacy: A Real-Life Study of Current Practice in Australia .” 2019. Web. 23 Jan 2021.

Vancouver:

Tan R. The Management of Allergic Rhinitis in the Community Pharmacy: A Real-Life Study of Current Practice in Australia . [Internet] [Thesis]. University of Sydney; 2019. [cited 2021 Jan 23]. Available from: http://hdl.handle.net/2123/21222.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Tan R. The Management of Allergic Rhinitis in the Community Pharmacy: A Real-Life Study of Current Practice in Australia . [Thesis]. University of Sydney; 2019. Available from: http://hdl.handle.net/2123/21222

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Cincinnati

27. Bermúdez, Mei-Ling. Carnosine as a Mechanism-based Intervention in the Thy1-aSyn Mouse Model of Parkinson’s Disease: Neurobehavioral, Biochemical, and Bioinformatic Analyses.

Degree: PhD, Medicine: Toxicology (Environmental Health), 2018, University of Cincinnati

URL: http://rave.ohiolink.edu/etdc/view?acc_num=ucin1543839362404126

► Parkinson's disease (PD) is the most common motor neurodegenerative disease worldwide, affecting millions of people. No cure exists for this devastating disease, which is characterized… (more)

▼ Parkinson's disease (PD) is the most common motor neurodegenerative disease worldwide, affecting millions of people. No cure exists for this devastating disease, which is characterized by non-motor and motor deficits, including resting tremor, gait instability, and decreased olfactory function. Hallmarks of PD include protein aggregates and the loss of dopaminergic neurons in the substantia nigra. PD is attributed to molecular mechanisms including oxidative stress, and mitochondrial dysfunction. These studies evaluated a novel, mechanism-based intervention for PD, using the Thy1-aSyn mouse model of PD, which overexpresses human wild-type alpha-synuclein (aSyn). These mice exhibit progressive non-motor and motor deficits as early as 2 months of age. The dipeptide carnosine was selected as an intervention based on its potential to enhance mitochondrial function, protect against oxidative stress, and reduce protein aggregation, which are key features of PD. In addition, carnosine in drinking water (DW) was previously reported to decrease protein aggregation in a mouse model of Alzheimer’s disease. The intranasal (IN) route is known as an effective means to administer therapeutics to the brain; therefore we compared IN and DW routes of carnosine exposure. The aims of this research project tested the hypothesis that IN administration of carnosine would significantly slow the progression of PD in Thy1-aSyn mice. Two-month old wild-type and Thy1-aSyn mice were treated with IN and DW carnosine, with controls receiving sterile waster intranasally or carnosine-free DW daily, respectively. After two months of treatment, the effects of carnosine were evaluated using bioinformatic, neurobehavioral, and biochemical analysis. The transcriptomic profile revealed that ribosomal and mitochondrial deficiencies associated with aSyn overexpression in Thy1-aSyn mice were attenuated by IN-carnosine administration in the midbrain. In addition to increasing the expression of mitochondrial genes, IN-carnosine increased the protein levels of complex V, complex IV activity, and mitochondrial function in Thy1-aSyn carnosine-treated mice compared to vehicle-treated controls. Motor and olfactory functions were tested with the challenging beam traversal (CBT) and the buried pellet (BP) tests, respectively, at the beginning and the end of the treatment period. In the CBT test, IN treated Thy1-aSyn committed fewer errors per step compared to vehicle-treated Thy1-aSyn mice. Olfactory function and tissue were preserved, and reduced levels of aSyn-positive inclusion were detected in the olfactory epithelium (OE) of IN-treated Thy-aSyn mice compared to Thy1-aSyn vehicle controls. For all endpoints studied, IN-carnosine performed superior to DW carnosine. Based on the beneficial results observed in young mice treated with IN-carnosine, studies were repeated in a subset of 8-month-old mice. At baseline, 8-month-old transgenic mice showed a progressive sensorimotor dysfunction, compared with 2-month-old mice. The results of this pilot study with aged mice… Advisors/Committee Members: Genter, Mary Beth (Committee Chair).

Subjects/Keywords: Toxicology; Parkinsons disease; Alpha-synuclein; Intranasal; Carnosine; Thy-aSyn mice; Mitochondria

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Bermúdez, M. (2018). Carnosine as a Mechanism-based Intervention in the Thy1-aSyn Mouse Model of Parkinson’s Disease: Neurobehavioral, Biochemical, and Bioinformatic Analyses. (Doctoral Dissertation). University of Cincinnati. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=ucin1543839362404126

Chicago Manual of Style (16^th Edition):

Bermúdez, Mei-Ling. “Carnosine as a Mechanism-based Intervention in the Thy1-aSyn Mouse Model of Parkinson’s Disease: Neurobehavioral, Biochemical, and Bioinformatic Analyses.” 2018. Doctoral Dissertation, University of Cincinnati. Accessed January 23, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1543839362404126.

MLA Handbook (7^th Edition):

Bermúdez, Mei-Ling. “Carnosine as a Mechanism-based Intervention in the Thy1-aSyn Mouse Model of Parkinson’s Disease: Neurobehavioral, Biochemical, and Bioinformatic Analyses.” 2018. Web. 23 Jan 2021.

Vancouver:

Bermúdez M. Carnosine as a Mechanism-based Intervention in the Thy1-aSyn Mouse Model of Parkinson’s Disease: Neurobehavioral, Biochemical, and Bioinformatic Analyses. [Internet] [Doctoral dissertation]. University of Cincinnati; 2018. [cited 2021 Jan 23]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=ucin1543839362404126.

Council of Science Editors:

Bermúdez M. Carnosine as a Mechanism-based Intervention in the Thy1-aSyn Mouse Model of Parkinson’s Disease: Neurobehavioral, Biochemical, and Bioinformatic Analyses. [Doctoral Dissertation]. University of Cincinnati; 2018. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=ucin1543839362404126

The Ohio State University

28. Colven, William Preston, DDS. A Pilot Study of Kovanaze Anesthetic In Children Age 6-8.

Degree: MS, Dentistry, 2019, The Ohio State University

URL: http://rave.ohiolink.edu/etdc/view?acc_num=osu1560425557327697

► Purpose: The purpose of this pilot study was to compare two local anesthetic administration techniques for maxillary dental procedures on primary teeth in children, in… (more)

Subjects/Keywords: Dentistry; Kovanaze; Local Anesthetic; Pediatric Dentistry; Lidocaine; Articaine; Intranasal

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Colven, William Preston, D. (2019). A Pilot Study of Kovanaze Anesthetic In Children Age 6-8. (Masters Thesis). The Ohio State University. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=osu1560425557327697

Chicago Manual of Style (16^th Edition):

Colven, William Preston, DDS. “A Pilot Study of Kovanaze Anesthetic In Children Age 6-8.” 2019. Masters Thesis, The Ohio State University. Accessed January 23, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=osu1560425557327697.

MLA Handbook (7^th Edition):

Colven, William Preston, DDS. “A Pilot Study of Kovanaze Anesthetic In Children Age 6-8.” 2019. Web. 23 Jan 2021.

Vancouver:

Colven, William Preston D. A Pilot Study of Kovanaze Anesthetic In Children Age 6-8. [Internet] [Masters thesis]. The Ohio State University; 2019. [cited 2021 Jan 23]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=osu1560425557327697.

Council of Science Editors:

Colven, William Preston D. A Pilot Study of Kovanaze Anesthetic In Children Age 6-8. [Masters Thesis]. The Ohio State University; 2019. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=osu1560425557327697

29. Levchenko, Natalie O. Intranasal Naloxone Adminstration Education.

Degree: MSN, 2016, University of San Francisco

URL: https://repository.usfca.edu/capstone/401

► The Clinical Nurse Leader project focused on the provision of education on intranasal naloxone administration to healthcare providers in Lake County in order to… (more)

Subjects/Keywords: naloxone; intranasal; opioid overdose; Public Health and Community Nursing

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APA (6^th Edition):

Levchenko, N. O. (2016). Intranasal Naloxone Adminstration Education. (Thesis). University of San Francisco. Retrieved from https://repository.usfca.edu/capstone/401

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Levchenko, Natalie O. “Intranasal Naloxone Adminstration Education.” 2016. Thesis, University of San Francisco. Accessed January 23, 2021. https://repository.usfca.edu/capstone/401.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Levchenko, Natalie O. “Intranasal Naloxone Adminstration Education.” 2016. Web. 23 Jan 2021.

Vancouver:

Levchenko NO. Intranasal Naloxone Adminstration Education. [Internet] [Thesis]. University of San Francisco; 2016. [cited 2021 Jan 23]. Available from: https://repository.usfca.edu/capstone/401.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Levchenko NO. Intranasal Naloxone Adminstration Education. [Thesis]. University of San Francisco; 2016. Available from: https://repository.usfca.edu/capstone/401

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

30. Pourbaghi Masouleh, Milad. Development of lipid nanocapsules for antiangiogenic treatment of glioblastoma and evaluation of their potential for nose-to-brain drug delivery : Développement de nanocapsules lipidiques pour le traitement anti-angiogénique du glioblastome et évaluation de leur potentiel pour la délivrance de médicaments au cerveau par voie intranasale.

Degree: Docteur es, Pharmacie, 2018, Angers; University of Nottingham

URL: http://www.theses.fr/2018ANGE0037

►

Le glioblastome (GB), tumeur primitive du cerveau, la plus agressive, et la plus fréquente chez l’adulte, présente une prolifération vasculaire importante. Des agents thérapeutiques innovants… (more)

▼

Le glioblastome (GB), tumeur primitive du cerveau, la plus agressive, et la plus fréquente chez l’adulte, présente une prolifération vasculaire importante. Des agents thérapeutiques innovants ciblant à la fois l'angiogenèse et les cellules tumorales sont recherchés, ainsi que des systèmes pour augmenter leur délivrance dans la tumeur cérébrale. Un de ces agents est le sorafénib (SFN), un inhibiteur de tyrosine kinase. Sa mauvaise solubilité aqueuse et ses effets secondaires indésirables limitent son utilisation. Le premier objectif de cette thèse était d'encapsuler cet agent dans des nanocapsules lipidiques (NCL) pour contrer ces inconvénients. Nous avons développé des NCL avec une haute efficacité d'encapsulation du SFN qui inhibaient in vitro l'angiogenèse et la viabilité de la lignée de GB humain U87MG. La délivrance intratumorale de SFN-NCL chez des souris porteuses d’une tumeur intracérébrale U87MG induit une normalisation vasculaire tumorale précoce qui pourrait améliorer l'efficacité de la chimiothérapie et de la radiothérapie. Le second objectif était de définir si la délivrance intranasale de NCL pouvait constituer une voie non-invasive alternative. Nous avons étudié via le transfert d'énergie par résonance de type Förster, le devenir des NCL chargées d’un fluorochrome à travers des monocouches de cellules Calu-3, un modèle de l'épithélium nasal. L'utilisation de NCL augmente le passage du fluorochrome à travers les cellules Calu-3, mais les particules sont rapidement dégradées après leur capture. Ces données mettent en évidence que les NCL sont appropriées pour la délivrance locale du SFN mais doivent être modifiées pour une délivrance intranasale.

Glioblastoma (GB), the most aggressive, and the most frequent primary tumor of the brain in adults, present a prominent vascular proliferation. Innovative therapeutic agents targeting both angiogenesis and tumor cells are urgently required, along with competent systems for their delivery to the brain tumor. One such agent is sorafenib (SFN), a tyrosine kinase inhibitor. However, poor aqueoussolubility and undesirable side effects limit its clinical application. The first objective of this thesis was to encapsulate this drug inside lipid nanocapsules(LNCs) to overcome these drawbacks. We developed LNCs with a high SFN encapsulation efficiency (>90%) that inhibited in vitro angiogenesis and the viability of the human U87MG GB cell line. Intratumoral delivery of SFN-LNCs in mice bearing intracerebral U87MG tumors induced early tumor vascular normalization which could be used to improve the efficacy of chemotherapy and radiotherapy in the treatment of GB. The second objective was to define whether intranasal delivery of LNCs could be an alternative non-invasive route. In this regard, we investigated through Förster resonance energy transfer, the fate of dye-loaded LNCs across Calu-3 cell monolayers, a model of the nasal mucosa. We showed that employment of LNCs dramatically increased the delivery of the dye acrossCalu-3 cell monolayer but they were rapidly…

Advisors/Committee Members: Menei, Philippe (thesis director), Stolnik-Trenkic, Snow (thesis director).

Subjects/Keywords: Glioblastome; Systèmes de délivrance; Anti-Angiogénique; Nanocapsule lipidique; Intranasal; Barrière épithéliale; Fret; Nanomédecine; Glioblastoma; Delivery systems; Anti-Angiogenic; Lipid nanocapsules; Intranasal; Epithelial barrier; Fret; Nanomedicine; 616.994; 615.58

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Pourbaghi Masouleh, M. (2018). Development of lipid nanocapsules for antiangiogenic treatment of glioblastoma and evaluation of their potential for nose-to-brain drug delivery : Développement de nanocapsules lipidiques pour le traitement anti-angiogénique du glioblastome et évaluation de leur potentiel pour la délivrance de médicaments au cerveau par voie intranasale. (Doctoral Dissertation). Angers; University of Nottingham. Retrieved from http://www.theses.fr/2018ANGE0037

Chicago Manual of Style (16^th Edition):

Pourbaghi Masouleh, Milad. “Development of lipid nanocapsules for antiangiogenic treatment of glioblastoma and evaluation of their potential for nose-to-brain drug delivery : Développement de nanocapsules lipidiques pour le traitement anti-angiogénique du glioblastome et évaluation de leur potentiel pour la délivrance de médicaments au cerveau par voie intranasale.” 2018. Doctoral Dissertation, Angers; University of Nottingham. Accessed January 23, 2021. http://www.theses.fr/2018ANGE0037.

MLA Handbook (7^th Edition):

Pourbaghi Masouleh, Milad. “Development of lipid nanocapsules for antiangiogenic treatment of glioblastoma and evaluation of their potential for nose-to-brain drug delivery : Développement de nanocapsules lipidiques pour le traitement anti-angiogénique du glioblastome et évaluation de leur potentiel pour la délivrance de médicaments au cerveau par voie intranasale.” 2018. Web. 23 Jan 2021.

Vancouver:

Pourbaghi Masouleh M. Development of lipid nanocapsules for antiangiogenic treatment of glioblastoma and evaluation of their potential for nose-to-brain drug delivery : Développement de nanocapsules lipidiques pour le traitement anti-angiogénique du glioblastome et évaluation de leur potentiel pour la délivrance de médicaments au cerveau par voie intranasale. [Internet] [Doctoral dissertation]. Angers; University of Nottingham; 2018. [cited 2021 Jan 23]. Available from: http://www.theses.fr/2018ANGE0037.

Council of Science Editors:

Pourbaghi Masouleh M. Development of lipid nanocapsules for antiangiogenic treatment of glioblastoma and evaluation of their potential for nose-to-brain drug delivery : Développement de nanocapsules lipidiques pour le traitement anti-angiogénique du glioblastome et évaluation de leur potentiel pour la délivrance de médicaments au cerveau par voie intranasale. [Doctoral Dissertation]. Angers; University of Nottingham; 2018. Available from: http://www.theses.fr/2018ANGE0037

Open Access Theses and Dissertations