subject:(Inflammatory bowel disease)

1. TIGHE, DONAL. Optimal use of immunomodulator and biological therapy in Inflammatory Bowel Disease.

Degree: School of Medicine. Discipline of Clinical Medicine, 2017, Trinity College Dublin

► Loss of response (LOR) to anti-TNFa therapy is a significant problem, and leads to increased hospitalisation rates, surgical intervention, and steroid dependency. Loss of response… (more)

▼ Loss of response (LOR) to anti-TNFa therapy is a significant problem, and leads to increased hospitalisation rates, surgical intervention, and steroid dependency. Loss of response is multifactorial. However there is an increasing awareness that immunogenicity has a significant role to play in this process. Immunogenicity against anti-TNFa leads to antibody formation. Antibodies against anti-TNFa lead to faster drug clearance, as well as blocking drug activity. This culminates in a reduction in anti-TNFa trough levels and loss of response. Therapeutic drug monitoring (TDM) allows anti-TNFa trough and antibody levels, to be measured and doses adjusted or treatment switched, to help overcome loss of response and improve outcomes. This thesis aimed to explore the impact of loss of response to anti-TNFa, and accurately identify predictors of loss of response. In addition to investigate the role of therapeutic drug monitoring, in assessing and overcoming loss of response. The main laboratory aspect of this thesis concerned the use of ELISA techniques, to accurately measure anti-TNFa trough and antibody levels. In brief a sandwich ELISA technique was used to detect anti-TNFa trough (infliximab & adalimumab) and antibody levels. ELISA microplates were coated with human TNFa. Horse radish peroxidise conjugated goat anti-human IgG Fc fragment antibody was added to serum samples, followed by diluted antibody. Substrate Solution tetramethylbenzidine (TMB) was added to each well, followed by the addition of stop solution. Drug concentrations in serum samples were determined using a standard curve generated from absorbance readings of infliximab or adalimumab. One arm of this thesis looked at a retrospective cohort study, which confirmed the impact of loss of response to anti-TNFa therapy, with an overall LOR rate of 42.5% for a cohort on maintenance treatment one year after commencing therapy. In addition this iv retrospective cohort study identified a number of key predictors of LOR, such as smoking, prior anti-TNFa therapy, as well as the protective benefits of combination therapy. Furthermore the link with biochemical response was confirmed, with a CRP <5 mg/L at the end of induction therapy being a significant predictor of clinical response. The potential and usefulness of TDM was also explored in further detail. A retrospective study looked at the role of role of measuring anti-TNFa trough and antibody levels in a stand-alone fashion. Analysis did not identify a relationship, but there was evidence that patients with low trough levels, and loss of response, had higher biochemical markers of disease activity. Therefore further work was undertaken to establish a role for TDM at the key time-points of end of induction therapy, and during an assessment for secondary loss of response. A prospective study looked at the role of TDM during induction therapy. There was a clear link between higher anti-TNFa trough levels at the end of induction with clinical response rates. For infliximab, mean trough levels in responders were… Advisors/Committee Members: McNamara, Deirdre.

Subjects/Keywords: Inflammatory Bowel Disease

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APA (6^th Edition):

TIGHE, D. (2017). Optimal use of immunomodulator and biological therapy in Inflammatory Bowel Disease. (Thesis). Trinity College Dublin. Retrieved from http://hdl.handle.net/2262/81873

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

TIGHE, DONAL. “Optimal use of immunomodulator and biological therapy in Inflammatory Bowel Disease.” 2017. Thesis, Trinity College Dublin. Accessed March 04, 2021. http://hdl.handle.net/2262/81873.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

TIGHE, DONAL. “Optimal use of immunomodulator and biological therapy in Inflammatory Bowel Disease.” 2017. Web. 04 Mar 2021.

Vancouver:

TIGHE D. Optimal use of immunomodulator and biological therapy in Inflammatory Bowel Disease. [Internet] [Thesis]. Trinity College Dublin; 2017. [cited 2021 Mar 04]. Available from: http://hdl.handle.net/2262/81873.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

TIGHE D. Optimal use of immunomodulator and biological therapy in Inflammatory Bowel Disease. [Thesis]. Trinity College Dublin; 2017. Available from: http://hdl.handle.net/2262/81873

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Melbourne

2. De Cruz, Peter-Philip. Post-operative Crohn's disease recurrence: clinical and microbiological studies.

Degree: 2012, University of Melbourne

URL: http://hdl.handle.net/11343/38028

► Crohn’s disease is a chronic inflammatory bowel disease that causes major morbidity. The cause is unknown but thought to relate to an exaggerated immune response… (more)

▼ Crohn’s disease is a chronic inflammatory bowel disease that causes major morbidity. The cause is unknown but thought to relate to an exaggerated immune response to gut microbiota in genetically susceptible individuals. There is currently no known cure. The majority of patients with Crohn’s disease undergo surgery during their life, and 70 percent of these require a second operation due to disease recurrence. Surgery involves removing the diseased segment and joining the unaffected bowel. Even if all macroscopically involved bowel is removed disease usually recurs at, and proximal to, the anastomosis. Recurrent Crohn’s disease can be identified endoscopically before symptoms develop. However, it is unknown whether intervention based on endoscopic findings of recurrence influences the disease course. Immunosuppressive and antitumour necrosis factor therapy have emerged as effective treatments in the treatment of Crohn’s disease but their optimal usage for the prevention of post-operative recurrence of Crohn’s disease remains to be determined. This thesis encompasses the design and conduct of a clinical study which aimed to determine whether prospective endoscopic monitoring of post-operative patients, with treatment intensification for mucosal recurrence, is superior to the current standard of care based on treatment of symptoms. This thesis also includes a laboratory study, allied to the clinical study, in which the microbiota has been characterised and followed over time, from a starting point of absent mucosal disease at a site of known recurrence. This latter study aimed to establish whether specific changes in gut mucosal microbiota at the anastomosis are associated with disease recurrence. We initially demonstrated in a retrospective cohort study that the rates of endoscopic, clinical, and surgical recurrence are high after surgery and that that approaches to the management of postoperative recurrence have been variable in the past. Although there was no clinical benefit from colonoscopy or step-up therapy in this cohort we concluded that that this lack of benefit related to inconsistent timing of post-operative colonoscopy and a lack of standardised drug intervention in response to the endoscopic findings. We then devised a prospective randomized controlled trial to compare endoscopic monitoring of post-operative patients with treatment step-up for endoscopic recurrence, with standard care. In an analysis of the six month endoscopic outcome of patients with a high risk of recurrence we found that adalimumab was significantly superior to thiopurines in preventing endoscopic recurrence. In the laboratory we simultaneously characterised the mucosa associated microbiota in a sub-group of patients enrolled in the clinical study at the time of surgical resection and at the anastomosis six months post-operatively. We found that patients…

Subjects/Keywords: inflammatory bowel disease

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APA (6^th Edition):

De Cruz, P. (2012). Post-operative Crohn's disease recurrence: clinical and microbiological studies. (Doctoral Dissertation). University of Melbourne. Retrieved from http://hdl.handle.net/11343/38028

Chicago Manual of Style (16^th Edition):

De Cruz, Peter-Philip. “Post-operative Crohn's disease recurrence: clinical and microbiological studies.” 2012. Doctoral Dissertation, University of Melbourne. Accessed March 04, 2021. http://hdl.handle.net/11343/38028.

MLA Handbook (7^th Edition):

De Cruz, Peter-Philip. “Post-operative Crohn's disease recurrence: clinical and microbiological studies.” 2012. Web. 04 Mar 2021.

Vancouver:

De Cruz P. Post-operative Crohn's disease recurrence: clinical and microbiological studies. [Internet] [Doctoral dissertation]. University of Melbourne; 2012. [cited 2021 Mar 04]. Available from: http://hdl.handle.net/11343/38028.

Council of Science Editors:

De Cruz P. Post-operative Crohn's disease recurrence: clinical and microbiological studies. [Doctoral Dissertation]. University of Melbourne; 2012. Available from: http://hdl.handle.net/11343/38028

Cornell University

3. Craven, Melanie. Comparative Analysis Of Host-Bacterial Interactions In The Gastrointestinal Tract.

Degree: PhD, Veterinary Medicine, 2011, Cornell University

URL: http://hdl.handle.net/1813/33572

► Technological advances in culture-independent methods using high throughput DNA sequencing have revolutionized our understanding of gastrointestinal (GI) microbiology. Our ability to now characterize the intestinal… (more)

▼ Technological advances in culture-independent methods using high throughput DNA sequencing have revolutionized our understanding of gastrointestinal (GI) microbiology. Our ability to now characterize the intestinal microbiome (IM) in incredible depth affords insight into the dynamic interrelationships of bacteria with the other pathomechanisms underlying inflammatory bowel diseases (IBD), i.e. genetics, immune dysregulation, and environmental triggers. This work explores these complex interactions in a murine model of Crohn‟s Disease (CD) and canine IBD. In C57BL/6 mice, we reveal that T. gondii and indomethacin-induced ileitis induce a microbial shift termed „dysbiosis,‟ comprising reduced microbial diversity and a global shift from >95% Gram+ (Firmicutes) to >95% Gramspecies (Proteobacteria), which recapitulates the IM of ileal CD. Gramproliferation also appears permissive to intramucosal invasion by the emerging pathogen, Adherent Invasive E. coli (AIEC). By manipulating genetic susceptibility to CD (NOD2-/-) and severity of ileitis (CCR2-/- and anti-TNF[alpha]mAb), we show that dysbiosis is the common end-point of acute ileitis, driven by inflammation rather than genotype or trigger. We postulate that failure to reverse dysbiosis stimulates chronic microbial-driven inflammation in CD. Unlike other GI pathology, e.g. Helicobacter-induced gastric ulceration, the evidence for a specific pathogen in CD is controversial, though growing evidence implicates AIEC. Pathogenicity of AIEC is highlighted by their firm association with Granulomatous colitis (GC) of Boxer dogs. We strengthen the evidence for a direct causal relationship by documenting intramucosally invasive E. coli in 17 GC cases. Further, GC remission correlates with E. coli sensitivity to enrofloxacin, whereas antimicrobial-resistant E. coli are associated with poor outcome. By genome-wide association study, we uncover for the first time parallels between GC and the colitis of human Chronic Granulomatous Disease (CGD), pointing to a potential role for AIEC in CGD pathogenesis. In idiopathic canine IBD, we demonstrate dysbiosis characterized by Bacteroidales depletion and increased Gram- diversity. We highlight potentially distinguishing features of the IM in IBD that warrant further evaluation as potential predictors of treatment response. In protein-losing enteropathy of Yorkshire Terriers, we document a severe, often fatal IBD, associated with sterile, multifocal crypt abscesses. Since we uncover no evidence of a bacterial etiology, we conclude that a familial morphogenetic disorder may be responsible. Advisors/Committee Members: Simpson, Kenneth William (chair), Denkers, Eric Young (committee member), McDonough, Sean P (committee member).

Subjects/Keywords: Dysbiosis; inflammatory bowel disease

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Craven, M. (2011). Comparative Analysis Of Host-Bacterial Interactions In The Gastrointestinal Tract. (Doctoral Dissertation). Cornell University. Retrieved from http://hdl.handle.net/1813/33572

Chicago Manual of Style (16^th Edition):

Craven, Melanie. “Comparative Analysis Of Host-Bacterial Interactions In The Gastrointestinal Tract.” 2011. Doctoral Dissertation, Cornell University. Accessed March 04, 2021. http://hdl.handle.net/1813/33572.

MLA Handbook (7^th Edition):

Craven, Melanie. “Comparative Analysis Of Host-Bacterial Interactions In The Gastrointestinal Tract.” 2011. Web. 04 Mar 2021.

Vancouver:

Craven M. Comparative Analysis Of Host-Bacterial Interactions In The Gastrointestinal Tract. [Internet] [Doctoral dissertation]. Cornell University; 2011. [cited 2021 Mar 04]. Available from: http://hdl.handle.net/1813/33572.

Council of Science Editors:

Craven M. Comparative Analysis Of Host-Bacterial Interactions In The Gastrointestinal Tract. [Doctoral Dissertation]. Cornell University; 2011. Available from: http://hdl.handle.net/1813/33572

University of Georgia

4. Knight, Eva Bonney Reed. Adherence in pediatric Inflammatory Bowel Disease.

Degree: 2014, University of Georgia

URL: http://hdl.handle.net/10724/26374

► Objective: To examine correlates and predictors of adolescent and parent reported adherence to prescription and over-the-counter (OTC) medications in a pediatric Inflammatory Bowel Disease sample… (more)

Subjects/Keywords: Adherence; Inflammatory Bowel Disease; Adolescence

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Knight, E. B. R. (2014). Adherence in pediatric Inflammatory Bowel Disease. (Thesis). University of Georgia. Retrieved from http://hdl.handle.net/10724/26374

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Knight, Eva Bonney Reed. “Adherence in pediatric Inflammatory Bowel Disease.” 2014. Thesis, University of Georgia. Accessed March 04, 2021. http://hdl.handle.net/10724/26374.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Knight, Eva Bonney Reed. “Adherence in pediatric Inflammatory Bowel Disease.” 2014. Web. 04 Mar 2021.

Vancouver:

Knight EBR. Adherence in pediatric Inflammatory Bowel Disease. [Internet] [Thesis]. University of Georgia; 2014. [cited 2021 Mar 04]. Available from: http://hdl.handle.net/10724/26374.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Knight EBR. Adherence in pediatric Inflammatory Bowel Disease. [Thesis]. University of Georgia; 2014. Available from: http://hdl.handle.net/10724/26374

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Oxford

5. Niehaus, Katherine. Phenotypic modelling of Crohn's disease severity : a machine learning approach.

Degree: PhD, 2017, University of Oxford

URL: http://ora.ox.ac.uk/objects/uuid:aa968762-8d1f-4d9b-8343-aaea33fcefbe ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.800051

► The growing availability of complex healthcare data holds great promise for improvements in medicine. However, new methodological developments are necessary to realise the potential of… (more)

▼ The growing availability of complex healthcare data holds great promise for improvements in medicine. However, new methodological developments are necessary to realise the potential of these resources. In this thesis we focused upon phenotypic modelling for chronic disease applications, specifically inflammatory bowel disease (IBD). Patients with IBD experience varying clinical trajectories, with the disease course ranging greatly in terms of severity. Our goal was to develop methods to capture IBD patient severity, using data from the electronic health record, and to then use our representations of severity to discover subgroups of patients with similar characteristics. The establishment of patient subgroups and associated genomic factors can enable precision medicine approaches to improve patient care. Faced with the challenge of unevenly-sampled and sparse clinical time series data, we have proposed a novel approach founded in extreme value theory (EVT) as a means to convert these measurements into interpretable metrics of patient abnormality. We show that our metrics are specifically useful in the modelling of IBD patients, as they provide a condensed representation of a patient's aggregate biochemistry and haematology dynamics. We also found that patient biomarker-based severity is much more representative of classical severity metrics for patients with ulcerative colitis (UC, one of the two primary IBD subtypes) than it is for patients with Crohn's disease (CD, the second subtype). Thus motivated to combine both our EVT-based and classical phenotypic representations of severity, we implemented a Bayesian clustering model so as to identify latent patient severity profiles. Our model is capable of handling missing data and inferring the number of underlying clusters. We found that consistent patient sub-groups were identifiable in our patient cohort, with the majority of CD patients falling into subgroups with severe phenotypic behaviour and the majority of UC patients exhibiting less severe behaviour. Having identified patient subgroups, we performed a hypothesis-generating association analysis to relate these subgroups (and other clinical features) to genetic loci previously associated with IBD susceptibility. We have presented a number of nominal associations, several of which have plausible biologic mechanisms. Finally, we have illustrated how we can use traditional approaches, machine learning techniques, and our presented EVT methods to answer a practical clinical question regarding the efficacy of two important IBD last-line medications. We examined these drugs in terms of their relative effectiveness, our ability to predict of patient response, and characterisation of this response. We were able to identify distinct ways in which patients respond to these drugs, while also finding that our retrospective data reveals no apparent difference between the two drugs in their effectiveness. In summary, we have developed a set of methods that can be applied to the challenging problem of finding patterns across…

Subjects/Keywords: Inflammatory bowel disease; Machine learning

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Niehaus, K. (2017). Phenotypic modelling of Crohn's disease severity : a machine learning approach. (Doctoral Dissertation). University of Oxford. Retrieved from http://ora.ox.ac.uk/objects/uuid:aa968762-8d1f-4d9b-8343-aaea33fcefbe ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.800051

Chicago Manual of Style (16^th Edition):

Niehaus, Katherine. “Phenotypic modelling of Crohn's disease severity : a machine learning approach.” 2017. Doctoral Dissertation, University of Oxford. Accessed March 04, 2021. http://ora.ox.ac.uk/objects/uuid:aa968762-8d1f-4d9b-8343-aaea33fcefbe ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.800051.

MLA Handbook (7^th Edition):

Niehaus, Katherine. “Phenotypic modelling of Crohn's disease severity : a machine learning approach.” 2017. Web. 04 Mar 2021.

Vancouver:

Niehaus K. Phenotypic modelling of Crohn's disease severity : a machine learning approach. [Internet] [Doctoral dissertation]. University of Oxford; 2017. [cited 2021 Mar 04]. Available from: http://ora.ox.ac.uk/objects/uuid:aa968762-8d1f-4d9b-8343-aaea33fcefbe ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.800051.

Council of Science Editors:

Niehaus K. Phenotypic modelling of Crohn's disease severity : a machine learning approach. [Doctoral Dissertation]. University of Oxford; 2017. Available from: http://ora.ox.ac.uk/objects/uuid:aa968762-8d1f-4d9b-8343-aaea33fcefbe ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.800051

Queens University

6. Diener, Jessica Ann. Everyone poops but no one wants to talk about it: The lived experiences of young people with inflammatory bowel disease .

Degree: Kinesiology and Health Studies, 2011, Queens University

URL: http://hdl.handle.net/1974/6638

► Crohn’s disease and Colitis, the two most common Inflammatory Bowel Diseases (IBD), are on the rise among young people. IBD symptoms include severe abdominal pain… (more)

▼ Crohn’s disease and Colitis, the two most common Inflammatory Bowel Diseases (IBD), are on the rise among young people. IBD symptoms include severe abdominal pain and frequent bowel movements, which can result in major dietary restrictions and delays in growth. IBD can also limit people’s physical activity, eating habits, and activities that are distant from a bathroom. Having IBD can be both limiting and embarrassing but little research has investigated the social and emotional implications of these diseases from a qualitative approach. Existing research fails to identify how stigma and dominant IBD discourses affect the lived experiences of people with IBD, young people in particular. IBD can create additional challenges for adolescents because it is perceived to threaten their normal development into healthy adults. The purpose of this project is to investigate how being young complicates the already difficult experience of being ill. I conducted interviews with three young people and a discursive analysis of official IBD resources for adolescents and found almost no descriptions of the actual experience of illness. Participants who engaged in photo-elicited interviews minimized the physical and emotional repercussions of having IBD. Informational resources designed for youth failed to address the severe physical and emotional pain of Crohn’s and Colitis. Instead, the available resources provided saccharine and arguably unrealistic depictions of IBD that deny young people a forum to express their own struggles. I compare my analysis of the interviews and IBD resources with my own experience and experiences presented in a zine. Analysis of both the interviews and the IBD resources reveals that young people with IBD can experience an embodied disappearance. Their bodies are smaller and weak, they retreat from social situations to avoid embarrassment, and their emotions are denied because they have no forums to be expressive. Finally, young people can experience a compounded disappearance because they are treated not for who they are but for what they should become. I argue that enabling young people the opportunity to speak candidly about the social conditions that contribute to their struggles could help them better understand, negotiate, and express their illness experiences

Subjects/Keywords: Youth ; Inflammatory Bowel Disease

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APA (6^th Edition):

Diener, J. A. (2011). Everyone poops but no one wants to talk about it: The lived experiences of young people with inflammatory bowel disease . (Thesis). Queens University. Retrieved from http://hdl.handle.net/1974/6638

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Diener, Jessica Ann. “Everyone poops but no one wants to talk about it: The lived experiences of young people with inflammatory bowel disease .” 2011. Thesis, Queens University. Accessed March 04, 2021. http://hdl.handle.net/1974/6638.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Diener, Jessica Ann. “Everyone poops but no one wants to talk about it: The lived experiences of young people with inflammatory bowel disease .” 2011. Web. 04 Mar 2021.

Vancouver:

Diener JA. Everyone poops but no one wants to talk about it: The lived experiences of young people with inflammatory bowel disease . [Internet] [Thesis]. Queens University; 2011. [cited 2021 Mar 04]. Available from: http://hdl.handle.net/1974/6638.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Diener JA. Everyone poops but no one wants to talk about it: The lived experiences of young people with inflammatory bowel disease . [Thesis]. Queens University; 2011. Available from: http://hdl.handle.net/1974/6638

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Guelph

7. Strauss, Jaclyn. Investigating a role for Fusobacterium nucleatum in Inflammatory Bowel Disease.

Degree: PhD, Department of Molecular and Cellular Biology, 2011, University of Guelph

URL: https://atrium.lib.uoguelph.ca/xmlui/handle/10214/2965

► Inflammatory Bowel Disease (IBD) is an umbrella term used to describe a group of chronic, relapsing/remitting disorders of the gastrointestinal tract (GIT). While the precise… (more)

Subjects/Keywords: Fusobacterium nucleatum; Inflammatory Bowel Disease

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APA (6^th Edition):

Strauss, J. (2011). Investigating a role for Fusobacterium nucleatum in Inflammatory Bowel Disease. (Doctoral Dissertation). University of Guelph. Retrieved from https://atrium.lib.uoguelph.ca/xmlui/handle/10214/2965

Chicago Manual of Style (16^th Edition):

Strauss, Jaclyn. “Investigating a role for Fusobacterium nucleatum in Inflammatory Bowel Disease.” 2011. Doctoral Dissertation, University of Guelph. Accessed March 04, 2021. https://atrium.lib.uoguelph.ca/xmlui/handle/10214/2965.

MLA Handbook (7^th Edition):

Strauss, Jaclyn. “Investigating a role for Fusobacterium nucleatum in Inflammatory Bowel Disease.” 2011. Web. 04 Mar 2021.

Vancouver:

Strauss J. Investigating a role for Fusobacterium nucleatum in Inflammatory Bowel Disease. [Internet] [Doctoral dissertation]. University of Guelph; 2011. [cited 2021 Mar 04]. Available from: https://atrium.lib.uoguelph.ca/xmlui/handle/10214/2965.

Council of Science Editors:

Strauss J. Investigating a role for Fusobacterium nucleatum in Inflammatory Bowel Disease. [Doctoral Dissertation]. University of Guelph; 2011. Available from: https://atrium.lib.uoguelph.ca/xmlui/handle/10214/2965

University of Toronto

8. Rahman, Adam. Self-screening for malnutrition risk in outpatient inflammatory bowel disease patients using the Malnutrition Universal Screening Tool.

Degree: 2016, University of Toronto

URL: http://hdl.handle.net/1807/79606

►

Background: Malnutrition is under-recognized in patients with inflammatory bowel disease (IBD). Aims To determine if patient can self-screen nutritional risk using the Malnutrition Universal Screening… (more)

Subjects/Keywords: Inflammatory Bowel Disease; Malnutrition; 0566

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APA (6^th Edition):

Rahman, A. (2016). Self-screening for malnutrition risk in outpatient inflammatory bowel disease patients using the Malnutrition Universal Screening Tool. (Masters Thesis). University of Toronto. Retrieved from http://hdl.handle.net/1807/79606

Chicago Manual of Style (16^th Edition):

Rahman, Adam. “Self-screening for malnutrition risk in outpatient inflammatory bowel disease patients using the Malnutrition Universal Screening Tool.” 2016. Masters Thesis, University of Toronto. Accessed March 04, 2021. http://hdl.handle.net/1807/79606.

MLA Handbook (7^th Edition):

Rahman, Adam. “Self-screening for malnutrition risk in outpatient inflammatory bowel disease patients using the Malnutrition Universal Screening Tool.” 2016. Web. 04 Mar 2021.

Vancouver:

Rahman A. Self-screening for malnutrition risk in outpatient inflammatory bowel disease patients using the Malnutrition Universal Screening Tool. [Internet] [Masters thesis]. University of Toronto; 2016. [cited 2021 Mar 04]. Available from: http://hdl.handle.net/1807/79606.

Council of Science Editors:

Rahman A. Self-screening for malnutrition risk in outpatient inflammatory bowel disease patients using the Malnutrition Universal Screening Tool. [Masters Thesis]. University of Toronto; 2016. Available from: http://hdl.handle.net/1807/79606

University of Manitoba

9. Chaity, Nazia. Genetics And Disease Associations Of Organic Cation Transporters With IBD – Special Emphasis On Genetic And Functional Studies Of SLC22A23.

Degree: Human Nutritional Sciences, 2015, University of Manitoba

URL: http://hdl.handle.net/1993/30788

► Inflammatory bowel disease (IBD) is a chronic disease which steadily increases worldwide with the highest prevalence in Canada. Genetic susceptibility is considered to be an… (more)

Subjects/Keywords: IBD- Inflammatory Bowel Disease; SLC22A23

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APA (6^th Edition):

Chaity, N. (2015). Genetics And Disease Associations Of Organic Cation Transporters With IBD – Special Emphasis On Genetic And Functional Studies Of SLC22A23. (Masters Thesis). University of Manitoba. Retrieved from http://hdl.handle.net/1993/30788

Chicago Manual of Style (16^th Edition):

Chaity, Nazia. “Genetics And Disease Associations Of Organic Cation Transporters With IBD – Special Emphasis On Genetic And Functional Studies Of SLC22A23.” 2015. Masters Thesis, University of Manitoba. Accessed March 04, 2021. http://hdl.handle.net/1993/30788.

MLA Handbook (7^th Edition):

Chaity, Nazia. “Genetics And Disease Associations Of Organic Cation Transporters With IBD – Special Emphasis On Genetic And Functional Studies Of SLC22A23.” 2015. Web. 04 Mar 2021.

Vancouver:

Chaity N. Genetics And Disease Associations Of Organic Cation Transporters With IBD – Special Emphasis On Genetic And Functional Studies Of SLC22A23. [Internet] [Masters thesis]. University of Manitoba; 2015. [cited 2021 Mar 04]. Available from: http://hdl.handle.net/1993/30788.

Council of Science Editors:

Chaity N. Genetics And Disease Associations Of Organic Cation Transporters With IBD – Special Emphasis On Genetic And Functional Studies Of SLC22A23. [Masters Thesis]. University of Manitoba; 2015. Available from: http://hdl.handle.net/1993/30788

University of New South Wales

10. Corte, Crispin. Improving the utility of colonoscopy in colorectal neoplasia and inflammatory bowel disease.

Degree: Clinical School - South Western Sydney, 2015, University of New South Wales

URL: http://handle.unsw.edu.au/1959.4/55311 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:37103/SOURCE02?view=true

► Background: Colorectal cancer is a common and commonly lethal disease. Colonoscopy is the gold standard for detection of colorectal cancer (CRC) and its precursor lesions,… (more)

▼ Background: Colorectal cancer is a common and commonly lethal disease. Colonoscopy is the gold standard for detection of colorectal cancer (CRC) and its precursor lesions, as well as for evaluation of colonic mucosa for diagnosis and assessment of inflammatory bowel disease (IBD). Australia has amongst the highest rates of colonsocopy per capita of any country. The utility of colonoscopy can be improved in a number of areas.This thesis examines a number of facets of colonoscopy to improve utility; improved methods of triage of colonoscopy, improving polyp detection using pharmacological methods, improving accuracy in assessing IBD during colonoscopy and minimising complications and physical harm at colonoscopy. Methods: Numerous studies were undertaken. A prospective cohort study including 645 patients was used to examine the Asia Pacific Colorectal Screening Score (APCS) in triage of colonoscopy. A randomized double blind placebo controlled trial including 608 patients was used to examine hyoscine butylbromide induced spasmolysis to improve polyp detection at colonoscopy. A retrospective cohort study was used to examine 93 patients with acute severe colitis (ASC) and the ulcerative colitis endoscopic index of severity (UCEIS) to correlate this with treatment outcomes. A meta-analysis was undertaken of previous studies of prophylactic measures to reduce post polypectomy haemorrhage (PPH). Results: The APCS is highly predictive of significant colonoscopic findings (RR 17.1 (95% CI 2.4-123; p=0.0001), and being underweight was protective of similar findings (OR 0.085, 0.011-0.625; p=0.015). Polyp detection was significantly improved (0.91 vs 0.70, p=0.044) by administering hyoscine butylbromide. UCEIS was correlated with outcomes of ASC and was highly predictive of the need for rescue therapy with biologic agents, colectomy and readmission (UCEIS 5 (3-8) vs 4 (3-7); p=0.0035). Meta-analysis demonstrated significant reductions in PPH with prophylactic measures, and an associate cost-benefit analysis confirmed cost saving with prophylaxis (RR for PPH with adrenaline vs placebo 0.28 (0.14-0.57, p<0.0001), NNT 12.3, cost to prevent one PPH USD1368.)Conclusion: Numerous advances can now be recommended to improve the utility, triage, appropriate use, accuracy of reporting, yield of pathology, and prevention of complications. These measures would serve to make colonoscopy a safer, more cost effective and more useful diagnostic and therapeutic tool. Advisors/Committee Members: Leong, Rupert, Clinical School - South Western Sydney, Faculty of Medicine, UNSW, Selby, Warwick, University of Sydney - Central Clinical School.

Subjects/Keywords: Gastroenterology; Inflammatory Bowel Disease; Colonoscopy

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APA (6^th Edition):

Corte, C. (2015). Improving the utility of colonoscopy in colorectal neoplasia and inflammatory bowel disease. (Doctoral Dissertation). University of New South Wales. Retrieved from http://handle.unsw.edu.au/1959.4/55311 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:37103/SOURCE02?view=true

Chicago Manual of Style (16^th Edition):

Corte, Crispin. “Improving the utility of colonoscopy in colorectal neoplasia and inflammatory bowel disease.” 2015. Doctoral Dissertation, University of New South Wales. Accessed March 04, 2021. http://handle.unsw.edu.au/1959.4/55311 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:37103/SOURCE02?view=true.

MLA Handbook (7^th Edition):

Corte, Crispin. “Improving the utility of colonoscopy in colorectal neoplasia and inflammatory bowel disease.” 2015. Web. 04 Mar 2021.

Vancouver:

Corte C. Improving the utility of colonoscopy in colorectal neoplasia and inflammatory bowel disease. [Internet] [Doctoral dissertation]. University of New South Wales; 2015. [cited 2021 Mar 04]. Available from: http://handle.unsw.edu.au/1959.4/55311 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:37103/SOURCE02?view=true.

Council of Science Editors:

Corte C. Improving the utility of colonoscopy in colorectal neoplasia and inflammatory bowel disease. [Doctoral Dissertation]. University of New South Wales; 2015. Available from: http://handle.unsw.edu.au/1959.4/55311 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:37103/SOURCE02?view=true

University of New South Wales

11. Lee, Hoyul. Elucidation of enteric virulence of Campylobacter concisus.

Degree: Biotechnology & Biomolecular Sciences, 2015, University of New South Wales

URL: http://handle.unsw.edu.au/1959.4/55659 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:38333/SOURCE02?view=true

► Campylobacter concisus is a Gram-negative mobile oral bacterium that has been shown to be associatedwith human inflammatory bowel disease. Various experiments were conducted in this… (more)

▼ Campylobacter concisus is a Gram-negative mobile oral bacterium that has been shown to be associatedwith human inflammatory bowel disease. Various experiments were conducted in this PhD project, aiming toelucidate the enteric virulence of C. concisus.The growth of oral C. concisus strains under different atmospheric conditions was examined. It was foundthat 92 % of strains grew under anaerobic conditions without H2. However, none of the strains grew undermicroaerobic conditions without H2. The presence H2 greatly increased the growth of C. concisus underanaerobic conditions and enabled C. concisus to grow under microaerobic conditions. The H2 had no effectson the expression of a number of putative virulence factors in C. concisus.The effects of formate and fumarate, on the production of H2S in oral C. concisus were investigated.Supplementation of formate and fumarate significantly increased the positivity of H2S production. Inaddition, the fumarate significantly increased C. concisus growth.Bioinformatics analysis was conducted to search for potential virulence factors encoded by prophages.Four prophage elements were identified in the genome of C. concisus strain 13826 with putative attachmentsites overlapping with tRNA. Each prophage elements contained a novel Xer phage integrase. It was foundthat CON_phi2 prophage encodes a Zot protein, and CON_phi3 encodes a Zot-like protein. Moreover, thephylogenetic analysis showed the horizontal gene transfer between Campylobacter species.Monoclonal antibody to C. concisus Zot was produced and verified. The impact of bile on the expressionof Zot was examined. It was found that a full length and a cleaved fragment of Zot were released from C.concisus in the presence of ox bile.Whether C. concisus strains affect actin in the intestinal epithelial cell line, Caco2 cells, was examined.Some C. concisus strains significantly reduced the levels of β-actin and caused the redistribution of F-actin inCaco2 cells.These findings show that the enteric virulence of C. concisus is determined by bacterial, host andenvironmental factors. Advisors/Committee Members: Zhang, Li, Biotechnology & Biomolecular Sciences, Faculty of Science, UNSW.

Subjects/Keywords: Campylobacter concisus; Inflammatory bowel disease

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APA (6^th Edition):

Lee, H. (2015). Elucidation of enteric virulence of Campylobacter concisus. (Doctoral Dissertation). University of New South Wales. Retrieved from http://handle.unsw.edu.au/1959.4/55659 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:38333/SOURCE02?view=true

Chicago Manual of Style (16^th Edition):

Lee, Hoyul. “Elucidation of enteric virulence of Campylobacter concisus.” 2015. Doctoral Dissertation, University of New South Wales. Accessed March 04, 2021. http://handle.unsw.edu.au/1959.4/55659 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:38333/SOURCE02?view=true.

MLA Handbook (7^th Edition):

Lee, Hoyul. “Elucidation of enteric virulence of Campylobacter concisus.” 2015. Web. 04 Mar 2021.

Vancouver:

Lee H. Elucidation of enteric virulence of Campylobacter concisus. [Internet] [Doctoral dissertation]. University of New South Wales; 2015. [cited 2021 Mar 04]. Available from: http://handle.unsw.edu.au/1959.4/55659 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:38333/SOURCE02?view=true.

Council of Science Editors:

Lee H. Elucidation of enteric virulence of Campylobacter concisus. [Doctoral Dissertation]. University of New South Wales; 2015. Available from: http://handle.unsw.edu.au/1959.4/55659 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:38333/SOURCE02?view=true

University of Alberta

12. El-Matary, Wael. Celiac disease in children with inflammatory bowel disease: a prospective cohort study.

Degree: MS, School Public Health Sciences, 2012, University of Alberta

URL: https://era.library.ualberta.ca/files/r781wg113

► The aim of this work was to examine any possible IBD activity-related variations in immunoglobulin A (IgA) anti-tissue transglutaminase (tTG) levels in children with IBD.… (more)

Subjects/Keywords: children; inflammatory bowel disease; celiac disease

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APA (6^th Edition):

El-Matary, W. (2012). Celiac disease in children with inflammatory bowel disease: a prospective cohort study. (Masters Thesis). University of Alberta. Retrieved from https://era.library.ualberta.ca/files/r781wg113

Chicago Manual of Style (16^th Edition):

El-Matary, Wael. “Celiac disease in children with inflammatory bowel disease: a prospective cohort study.” 2012. Masters Thesis, University of Alberta. Accessed March 04, 2021. https://era.library.ualberta.ca/files/r781wg113.

MLA Handbook (7^th Edition):

El-Matary, Wael. “Celiac disease in children with inflammatory bowel disease: a prospective cohort study.” 2012. Web. 04 Mar 2021.

Vancouver:

El-Matary W. Celiac disease in children with inflammatory bowel disease: a prospective cohort study. [Internet] [Masters thesis]. University of Alberta; 2012. [cited 2021 Mar 04]. Available from: https://era.library.ualberta.ca/files/r781wg113.

Council of Science Editors:

El-Matary W. Celiac disease in children with inflammatory bowel disease: a prospective cohort study. [Masters Thesis]. University of Alberta; 2012. Available from: https://era.library.ualberta.ca/files/r781wg113

University of Saskatchewan

13. Alrefai, Dania 1987-. The impact of vitamin D on disease activity in Crohn's disease.

Degree: 2015, University of Saskatchewan

URL: http://hdl.handle.net/10388/12648

► Canada has the highest rate of Inflammatory Bowel Disease (IBD) in the world with approximately 0.67%. One of the primary nutritional health issues faced by… (more)

▼ Canada has the highest rate of Inflammatory Bowel Disease (IBD) in the world with approximately 0.67%. One of the primary nutritional health issues faced by Crohn’s disease (CD) patients is vitamin D deficiency, which can subsequently lead to more serious health complications. Vitamin D is shown to act as a modulator for the autoimmune system among CD patients. Phase I study aimed to determine vitamin D concentrations and disease activity among CD cases in Canada and Saudi Arabia, and evaluate the impact of higher doses of vitamin D compared to EAR on disease activity among CD patients. This pilot study was a double blind, randomized, control trial involving approximately 60 recent, active CD patients engaged in induction therapy. The sample size includes patients in Saskatoon, Saskatchewan, Canada (n=30) and Riyadh, Saudi Arabia (n=30). The patients have been divided into three groups to receive different oral doses of vitamin D including: 1: 400 IU/day (Control group, EAR level) 2: 2,000 IU/day 3: 10,000 IU/day. Data were collected at baseline (0), end of 9 weeks (end of intervention), and at 2 months follow-up. Along with anthropometric measurements participants undergo laboratory examinations such as, WBC, HGB, Hct, platelets, ferritin, vitamin D, hsCRP and calprotection, undertake the Health related quality of life (HRQOL), and fill out socio-demographic and physical activity questionnaires. We also assessed their dietary intake at the baseline and Week 9 using two sets of three 24-hour dietary recalls. Due to a small sample size (n=9 cases) we have recruited, we presented Phase I as a case series. Phase II study determined the association between vitamin D concentrations and disease activity among CD cohort in Saskatoon, Canada. In a retrospective cohort design, we studied 201 CD patients; 116 participants had vitamin D data. We extracted data from medical records over three years at IBD clinic, Royal University Hospital, Saskatoon, Canada. I evaluated the association between vitamin D status (serum 25OHD) and indicator of disease activity (hsCRP) as well as Harvey-Bradshaw index (HBI) in CD patients. The analyses conducted in the presence of other potential factors in three-time points (baseline, midpoint, last visit) using generalized estimating equation (GEE). Vitamin D concentrations was improved significantly from baseline to the last visit (p=0.005). At the baseline, mean 25OHD was 58.2±30.0 nmol/L; 26% of patients had optimal, 30% had adequate, 26% had insufficient, and 18% patients had deficient vitamin D levels. At the midpoint, mean serum vitamin D concentrations was 60.1±31.2 nmol/L; 31.3% had optimal level, 31,3% patients had insufficient level, 22.1% patients had adequate level, and 15.2% patients were vitamin D deficient. At final visit, mean vitamin D was 74.5±42.6 nmol/L; 43.9% patients had optimal and 24.2% patients had adequate levels of vitamin D, while 18.1% patients were vitamin D insufficient and 13.6% patients had vitamin D deficiency. Vitamin D concentrations showed significant inverse… Advisors/Committee Members: Vatanparast, Hassan, Jones, Jennifer, El-Matary, Wael, Aljebreen, Abdulrahman.

Subjects/Keywords: Crohn's disease; inflammatory bowel disease; vitamin D

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APA (6^th Edition):

Alrefai, D. 1. (2015). The impact of vitamin D on disease activity in Crohn's disease. (Thesis). University of Saskatchewan. Retrieved from http://hdl.handle.net/10388/12648

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Alrefai, Dania 1987-. “The impact of vitamin D on disease activity in Crohn's disease.” 2015. Thesis, University of Saskatchewan. Accessed March 04, 2021. http://hdl.handle.net/10388/12648.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Alrefai, Dania 1987-. “The impact of vitamin D on disease activity in Crohn's disease.” 2015. Web. 04 Mar 2021.

Vancouver:

Alrefai D1. The impact of vitamin D on disease activity in Crohn's disease. [Internet] [Thesis]. University of Saskatchewan; 2015. [cited 2021 Mar 04]. Available from: http://hdl.handle.net/10388/12648.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Alrefai D1. The impact of vitamin D on disease activity in Crohn's disease. [Thesis]. University of Saskatchewan; 2015. Available from: http://hdl.handle.net/10388/12648

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Texas A&M University

14. Heilmann, Romy Monika. Evaluation of Canine S100A12 and sRAGE as Novel Disease.

Degree: PhD, Biomedical Sciences, 2015, Texas A&M University

URL: http://hdl.handle.net/1969.1/155105

► Inflammatory bowel disease (IBD) is a common condition in dogs that is challenging to diagnose. A dysregulated innate immunity plays a major role in its… (more)

▼ Inflammatory bowel disease (IBD) is a common condition in dogs that is challenging to diagnose. A dysregulated innate immunity plays a major role in its pathogenesis, and surrogate inflammatory markers that reflect disease severity would be clinically useful. S100A12, a damage-associated molecular pattern molecule, is involved in phagocyte activation. S100A12 binds to the receptor of advanced glycation end products (RAGE), a pattern-recognition receptor, and results in human studies suggest a role of S100A12 and RAGE in chronic inflammation. Soluble RAGE (sRAGE), a decoy receptor, functions as an anti-inflammatory molecule. S100A12 and RAGE/sRAGE have not been studied in canine IBD. Canine S100A12 has not been purified, and while an immunoassay for measurement of S100A12 in humans is available, human antibodies do not cross-react with canine S100A12 (cS100A12). Canine RAGE has been cloned and characterized. The aims of this project were to purify and partially characterize cS100A12, to develop and analytically validate an immunoassay for cS100A12, and to determine the relationship between cS100A12 and systemic sRAGE concentrations and clinical, endoscopic, and histologic disease severity in dogs with IBD. Markers of gastrointestinal inflammation were also evaluated in dogs with acute hemorrhagic diarrhea syndrome (AHDS). Canine S100A12 was successfully purified from canine whole blood, and a competitive liquid-phase radioimmunoassay was developed and analytically validated. Fecal cS100A12 concentrations were shown to be increased in dogs with IBD and were associated with clinical disease activity, the severity of endoscopic lesions, and the severity of colonic inflammation. Serum sRAGE concentrations were decreased in dogs with IBD, but were not correlated with disease severity, cS100A12 concentrations, or outcome. Dogs that were euthanized had higher fecal cS100A12 concentrations than dogs that were alive at the end of the study, and serum sRAGE concentrations increased only in IBD dogs with complete clinical remission. A significant but transient increase in fecal cS100A12 was also seen in dogs with AHDS. Fecal cS100A12 may be clinically useful as a biomarker of inflammation in dogs with IBD, and the sRAGE/RAGE axis appears to be altered in canine IBD. Lack of correlation between sRAGE and cS100A12 is consistent with sRAGE being a non-specific decoy receptor. Advisors/Committee Members: Steiner, Jörg M (advisor), Suchodolski, Jan S (advisor), Pool, Roy (committee member), Jergens, Albert E (committee member), Allenspach, Karin (committee member).

Subjects/Keywords: S100A12; sRAGE; calgranulin; canine; inflammatory bowel disease

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APA (6^th Edition):

Heilmann, R. M. (2015). Evaluation of Canine S100A12 and sRAGE as Novel Disease. (Doctoral Dissertation). Texas A&M University. Retrieved from http://hdl.handle.net/1969.1/155105

Chicago Manual of Style (16^th Edition):

Heilmann, Romy Monika. “Evaluation of Canine S100A12 and sRAGE as Novel Disease.” 2015. Doctoral Dissertation, Texas A&M University. Accessed March 04, 2021. http://hdl.handle.net/1969.1/155105.

MLA Handbook (7^th Edition):

Heilmann, Romy Monika. “Evaluation of Canine S100A12 and sRAGE as Novel Disease.” 2015. Web. 04 Mar 2021.

Vancouver:

Heilmann RM. Evaluation of Canine S100A12 and sRAGE as Novel Disease. [Internet] [Doctoral dissertation]. Texas A&M University; 2015. [cited 2021 Mar 04]. Available from: http://hdl.handle.net/1969.1/155105.

Council of Science Editors:

Heilmann RM. Evaluation of Canine S100A12 and sRAGE as Novel Disease. [Doctoral Dissertation]. Texas A&M University; 2015. Available from: http://hdl.handle.net/1969.1/155105

University of Newcastle

15. Mateer, Sean W. Mechanism of lung inflammation associated with inflammatory bowel disease.

Degree: PhD, 2017, University of Newcastle

URL: http://hdl.handle.net/1959.13/1342488

►

Research Doctorate - Doctor of Philosophy (PhD)

Inflammatory bowel disease (IBD) is associated with a number of immune-mediated pathologies in peripheral tissues, termed extra-intestinal manifestations… (more)

▼

Research Doctorate - Doctor of Philosophy (PhD)

Inflammatory bowel disease (IBD) is associated with a number of immune-mediated pathologies in peripheral tissues, termed extra-intestinal manifestations (EIM). The organs affected by EIM include the lung, liver, skin and eyes. IBD-induced respiratory pathologies are amongst the most prevalent comorbidities associated with IBD. Approximately 54% of IBD patients have some form of respiratory pathology. The respiratory pathologies associated with IBD range from subclinical respiratory inflammation to active respiratory disease. Bronchiectasis and chronic bronchitis are the most common respiratory diseases associated with IBD. The mechanism by which IBD can induce respiratory pathologies is unknown, this knowledge gap is partially due to a lack of basic science research in this field. Thus, the aim of this study was to utilize murine models of colitis to investigate the immunological mechanisms by which IBD can induce respiratory inflammation. In this study it was found that the DSS, TNBS and <i>Winnie</i> models of colitis develop pulmonary inflammation that is associated with leucocyte infiltration surrounding the pulmonary vasculature. Pulmonary inflammation in DSS colitis is characterised by neutrophil and monocyte recruitment to the lung. Systemic IL-6 levels were elevated in the DSS colitis model and IL-6 was identified to be a factor that contributes to neutrophil recruitment. It was found that systemic IL-6 mediates neutrophil development in the bone marrow thereby providing the cells required to perpetuate inflammation in the lung. Platelet activating factor receptor (PAFR), IL-1β and CCL2 expression were increased in the lungs of DSS colitis mice. PAFR signalling in the lung induces the expression of IL-1β and the recruitment of neutrophils, PAFR signalling did not induce CCL2 expression. It was found that immunomodulatory factors in the serum of DSS colitis induce IL-1β production and CCL2 gene expression in alveolar macrophage through PAFR signalling. The results from this study identify a number of potential pathogenic factors that may be involved in the development of IBD-induced respiratory pathologies.

Advisors/Committee Members: University of Newcastle. Faculty of Health & Medicine, School of Biomedical Sciences and Pharmacy.

Subjects/Keywords: inflammatory bowel disease; immunology; systemic inflammation; PAFR

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APA (6^th Edition):

Mateer, S. W. (2017). Mechanism of lung inflammation associated with inflammatory bowel disease. (Doctoral Dissertation). University of Newcastle. Retrieved from http://hdl.handle.net/1959.13/1342488

Chicago Manual of Style (16^th Edition):

Mateer, Sean W. “Mechanism of lung inflammation associated with inflammatory bowel disease.” 2017. Doctoral Dissertation, University of Newcastle. Accessed March 04, 2021. http://hdl.handle.net/1959.13/1342488.

MLA Handbook (7^th Edition):

Mateer, Sean W. “Mechanism of lung inflammation associated with inflammatory bowel disease.” 2017. Web. 04 Mar 2021.

Vancouver:

Mateer SW. Mechanism of lung inflammation associated with inflammatory bowel disease. [Internet] [Doctoral dissertation]. University of Newcastle; 2017. [cited 2021 Mar 04]. Available from: http://hdl.handle.net/1959.13/1342488.

Council of Science Editors:

Mateer SW. Mechanism of lung inflammation associated with inflammatory bowel disease. [Doctoral Dissertation]. University of Newcastle; 2017. Available from: http://hdl.handle.net/1959.13/1342488

University of Ottawa

16. Deeke, Shelley. Biomarker Discovery and Extracellular Vesicle Proteomic Signatures in Pediatric Inflammatory Bowel Disease .

Degree: 2019, University of Ottawa

URL: http://hdl.handle.net/10393/38660

► Background: Reliable biomarkers are needed to evade the risk of injury, invasiveness and discomfort of endoscopies, which are required for inflammatory bowel disease (IBD) diagnosis… (more)

▼ Background: Reliable biomarkers are needed to evade the risk of injury, invasiveness and discomfort of endoscopies, which are required for inflammatory bowel disease (IBD) diagnosis and extent of disease assessment in ulcerative colitis (UC) patients. The need for biomarkers is accentuated in children, wherein the most frequently used IBD biomarker yields low specificity. Proteomics of clinical samples or their enriched components is a means to evaluate and identify alterations in proteins reflective of disease, with the potential for use as biomarkers and for providing insight on disease pathogenesis. Methods: Proteins were isolated from the intestinal mucosal-luminal interface (MLI), collected from the ascending and descending colon of pediatric treatment-naive patients. The intestinal MLI proteomes of 42 IBD and 18 control patients were analyzed by high resolution mass spectrometry (HRMS). Multivariate analysis and receiver operating characteristics curves were performed to develop protein biomarker panels to discriminate IBD from control, and for UC extent of disease. ELISAs were used to assess a subset of biomarker candidates in stool samples from an independent pediatric cohort (n=24). Extracellular vesicles (EVs) were isolated by ultracentrifugation from the intestinal MLI of 11 IBD and seven control patients, and analyzed by electron microscopy, nanoparticle tracking analysis and HRMS. Results: A biomarker panel of four proteins classified patients as either controls or active IBD with 97.5% accuracy. A second biomarker panel correctly classified 100% of UC patients as presenting with pancolitis or non-pancolitis. The differential protein expression of two biomarker candidates (catalase and leukotriene A-4 hydrolase) identified from the intestinal MLI was comparable in stool samples. Comparison of EV proteomes isolated from IBD patients and controls identified differential expression of processes related to host defense and immunity. Conclusions: Proteomic analysis of clinical samples identified differentially expressed proteins that can classify IBD patients from non-IBD controls and distinguish UC patients with pancolitis from those without pancolitis; proteins identified in intestinal aspirates displayed consistent differential expression in stool. Furthermore enrichment of EVs from the intestinal MLI indicates that these may contribute to the dysregulated host response against the intestinal microbiota which is observed in IBD.

Subjects/Keywords: Biomarkers; Proteomics; Inflammatory bowel disease; ulcerative colitis

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APA (6^th Edition):

Deeke, S. (2019). Biomarker Discovery and Extracellular Vesicle Proteomic Signatures in Pediatric Inflammatory Bowel Disease . (Thesis). University of Ottawa. Retrieved from http://hdl.handle.net/10393/38660

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Deeke, Shelley. “Biomarker Discovery and Extracellular Vesicle Proteomic Signatures in Pediatric Inflammatory Bowel Disease .” 2019. Thesis, University of Ottawa. Accessed March 04, 2021. http://hdl.handle.net/10393/38660.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Deeke, Shelley. “Biomarker Discovery and Extracellular Vesicle Proteomic Signatures in Pediatric Inflammatory Bowel Disease .” 2019. Web. 04 Mar 2021.

Vancouver:

Deeke S. Biomarker Discovery and Extracellular Vesicle Proteomic Signatures in Pediatric Inflammatory Bowel Disease . [Internet] [Thesis]. University of Ottawa; 2019. [cited 2021 Mar 04]. Available from: http://hdl.handle.net/10393/38660.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Deeke S. Biomarker Discovery and Extracellular Vesicle Proteomic Signatures in Pediatric Inflammatory Bowel Disease . [Thesis]. University of Ottawa; 2019. Available from: http://hdl.handle.net/10393/38660

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Boston University

17. Kim, Jochebed. Serum and fecal biomarkers predict response to Infliximab therapy in pediatric patients with Inflammatory Bowel Disease.

Degree: MS, Medical Sciences, 2020, Boston University

URL: http://hdl.handle.net/2144/41280

► Inflammatory Bowel Disease (IBD) is a chronic, idiopathic autoimmune disease characterized by the inflammation of the GI tract. The main subcategories of IBD include Crohn… (more)

▼ Inflammatory Bowel Disease (IBD) is a chronic, idiopathic autoimmune disease characterized by the inflammation of the GI tract. The main subcategories of IBD include Crohn Disease (CD), ulcerative colitis (UC), and Indeterminate Colitis (IC). Currently, IBD is diagnosed and evaluated using clinical, endoscopic, biochemical, and histologic measures - which can be invasive and costly. Previous studies have shown that measurement of serum and fecal inflammatory biomarkers might be effective both for the assessment of intestinal infectious or inflammatory processes, as well as for gauging IBD disease activity. Inflammatory biomarkers investigated in this study include serum and fecal Anti-Saccharomyces-Cerevisiae Antibody (ASCA), serum and fecal lactoferrin, fecal calprotectin, fecal hemoglobin, IL1-𝛼, IL1-β, erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP). IMPACT-III questionnaires are utilized to measure the quality of life in enrolled subjects. Data collected in this study investigated the relationship between changes in serum and fecal biomarker levels, clinical disease activity, and the mental wellbeing of patients. The primary objective was to measure changes in inflammatory biomarker levels in patients with CD, UC, and IC after being treated with the anti-TNF therapy Infliximab (Remicade). The second objective is to study the relationship between changes in these biomarker levels and the clinical, biochemical, and endoscopic outcome parameters of IBD in patients. This is a multicenter, longitudinal, cohort study following 50 pediatric patients with IBD over the course of six Remicade infusion appointments. The project was conducted in partnership with Riley’s Children Hospital in Indianapolis. Patients with CD, UC, and IC were recruited for the study and stratified with respect to the temporal phase of their Remicade infusions, including: • Induction • Past induction, but less than 6 months • Those who have been receiving Remicade for over one year. A total of 58 eligible IBD patients are currently enrolled. 13 patients have withdrawn from the study, leaving 45 active patients: 27 CD, 17 UC, and 1 IC remaining in the prospective cohort. Patients provided serum and fecal samples and completed IMPACT-III questionnaires at the time of each Remicade infusion. Baseline serum ASCA levels were 0.014 ±0.029 OD from (n=15) patients with CD, 0.0083 ±0.022 OD in (n=12) patients with UC, and 0.002 OD in one patient with IC. Baseline fecal ASCA levels were 0.068 ±0.186 OD in (n=10) patients with CD, 0.0018 ±0.0013 OD in (n=9) patients with UC, and 0.001 OD in one patient with IC. At both baseline and at the time of the first infusion, CRP levels were significantly higher in patients with CD (p<0.05). At the time of the first infusion, the ESR in patients with CD was significantly higher than that in patients with UC (p<0.10). Serum lactoferrin was significantly higher in patients with UC at infusion 2 (p<0.05). ESR was significantly higher in patients with UC (p<0.10) at their fourth infusion. … Advisors/Committee Members: Garcia-Diaz, Fernando (advisor), Rufo, Paul (advisor).

Subjects/Keywords: Medicine; Gastroenterology; Inflammatory Bowel Disease; Remicade

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APA (6^th Edition):

Kim, J. (2020). Serum and fecal biomarkers predict response to Infliximab therapy in pediatric patients with Inflammatory Bowel Disease. (Masters Thesis). Boston University. Retrieved from http://hdl.handle.net/2144/41280

Chicago Manual of Style (16^th Edition):

Kim, Jochebed. “Serum and fecal biomarkers predict response to Infliximab therapy in pediatric patients with Inflammatory Bowel Disease.” 2020. Masters Thesis, Boston University. Accessed March 04, 2021. http://hdl.handle.net/2144/41280.

MLA Handbook (7^th Edition):

Kim, Jochebed. “Serum and fecal biomarkers predict response to Infliximab therapy in pediatric patients with Inflammatory Bowel Disease.” 2020. Web. 04 Mar 2021.

Vancouver:

Kim J. Serum and fecal biomarkers predict response to Infliximab therapy in pediatric patients with Inflammatory Bowel Disease. [Internet] [Masters thesis]. Boston University; 2020. [cited 2021 Mar 04]. Available from: http://hdl.handle.net/2144/41280.

Council of Science Editors:

Kim J. Serum and fecal biomarkers predict response to Infliximab therapy in pediatric patients with Inflammatory Bowel Disease. [Masters Thesis]. Boston University; 2020. Available from: http://hdl.handle.net/2144/41280

University of Debrecen

18. Njikam Chamna, Laurence. Pharmacological treatment of inflammatory bowel disease .

Degree: DE – Általános Orvostudományi Kar, University of Debrecen

URL: http://hdl.handle.net/2437/218641

► Pharmacological therapy of inflammatory bowel disease with their potential side effect. Supportive therapy and surgical treatment methods.Epidemiology , etiology and pathogenesis. Complication in pregnant women.… (more)

Subjects/Keywords: Inflammatory bowel disease

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APA (6^th Edition):

Njikam Chamna, L. (n.d.). Pharmacological treatment of inflammatory bowel disease . (Thesis). University of Debrecen. Retrieved from http://hdl.handle.net/2437/218641

Note: this citation may be lacking information needed for this citation format:
No year of publication.
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Njikam Chamna, Laurence. “Pharmacological treatment of inflammatory bowel disease .” Thesis, University of Debrecen. Accessed March 04, 2021. http://hdl.handle.net/2437/218641.

Note: this citation may be lacking information needed for this citation format:
No year of publication.
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Njikam Chamna, Laurence. “Pharmacological treatment of inflammatory bowel disease .” Web. 04 Mar 2021.

Note: this citation may be lacking information needed for this citation format:
No year of publication.

Vancouver:

Njikam Chamna L. Pharmacological treatment of inflammatory bowel disease . [Internet] [Thesis]. University of Debrecen; [cited 2021 Mar 04]. Available from: http://hdl.handle.net/2437/218641.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
No year of publication.

Council of Science Editors:

Njikam Chamna L. Pharmacological treatment of inflammatory bowel disease . [Thesis]. University of Debrecen; Available from: http://hdl.handle.net/2437/218641

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
No year of publication.

University of Debrecen

19. Hatlestad, Maren Rytilahti. Biological Therapy In Inflammatory Bowel Disease .

Degree: DE – Általános Orvostudományi Kar, University of Debrecen

URL: http://hdl.handle.net/2437/229598

► Inflammatory bowel disease (IBD) represents a group of chronic disorders of the gastrointestinal tract, subdivided into Crohns disease (CD) and ulcerative colitis (UC). Although the… (more)

Subjects/Keywords: inflammatory bowel disease

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APA (6^th Edition):

Hatlestad, M. R. (n.d.). Biological Therapy In Inflammatory Bowel Disease . (Thesis). University of Debrecen. Retrieved from http://hdl.handle.net/2437/229598

Note: this citation may be lacking information needed for this citation format:
No year of publication.
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Hatlestad, Maren Rytilahti. “Biological Therapy In Inflammatory Bowel Disease .” Thesis, University of Debrecen. Accessed March 04, 2021. http://hdl.handle.net/2437/229598.

Note: this citation may be lacking information needed for this citation format:
No year of publication.
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Hatlestad, Maren Rytilahti. “Biological Therapy In Inflammatory Bowel Disease .” Web. 04 Mar 2021.

Note: this citation may be lacking information needed for this citation format:
No year of publication.

Vancouver:

Hatlestad MR. Biological Therapy In Inflammatory Bowel Disease . [Internet] [Thesis]. University of Debrecen; [cited 2021 Mar 04]. Available from: http://hdl.handle.net/2437/229598.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
No year of publication.

Council of Science Editors:

Hatlestad MR. Biological Therapy In Inflammatory Bowel Disease . [Thesis]. University of Debrecen; Available from: http://hdl.handle.net/2437/229598

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
No year of publication.

University of Debrecen

20. Srour, Nicolas Nihad. Pharmacotherapy of inflammatoy bowel disease .

Degree: DE – Általános Orvostudományi Kar, University of Debrecen

URL: http://hdl.handle.net/2437/233624

► this thesis deals with the pharmacological therapy of Crohn's disease and Ulcerative colitis , explaining the main pathological findings and the corresponding treatment , the… (more)

Subjects/Keywords: inflammatory bowel disease

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APA (6^th Edition):

Srour, N. N. (n.d.). Pharmacotherapy of inflammatoy bowel disease . (Thesis). University of Debrecen. Retrieved from http://hdl.handle.net/2437/233624

Note: this citation may be lacking information needed for this citation format:
No year of publication.
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Srour, Nicolas Nihad. “Pharmacotherapy of inflammatoy bowel disease .” Thesis, University of Debrecen. Accessed March 04, 2021. http://hdl.handle.net/2437/233624.

Note: this citation may be lacking information needed for this citation format:
No year of publication.
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Srour, Nicolas Nihad. “Pharmacotherapy of inflammatoy bowel disease .” Web. 04 Mar 2021.

Note: this citation may be lacking information needed for this citation format:
No year of publication.

Vancouver:

Srour NN. Pharmacotherapy of inflammatoy bowel disease . [Internet] [Thesis]. University of Debrecen; [cited 2021 Mar 04]. Available from: http://hdl.handle.net/2437/233624.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
No year of publication.

Council of Science Editors:

Srour NN. Pharmacotherapy of inflammatoy bowel disease . [Thesis]. University of Debrecen; Available from: http://hdl.handle.net/2437/233624

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
No year of publication.

Boston University

21. Collins, Derek Alexander. The impact of coping strategies exercised by children and their families on clinical management, disease outcome, and emotional well-being in children with newly diagnosed inflammatory bowel disease.

Degree: MS, Medical Sciences, 2019, Boston University

URL: http://hdl.handle.net/2144/36301

► BACKGROUND: Inflammatory bowel disease (IBD) is a group of conditions characterized by chronic inflammation of the gastrointestinal (GI) tract. A new diagnosis of IBD in… (more)

▼ BACKGROUND: Inflammatory bowel disease (IBD) is a group of conditions characterized by chronic inflammation of the gastrointestinal (GI) tract. A new diagnosis of IBD in children and adolescents can have significant psychosocial effects on both the patient and the family. Child and parental coping strategies play a crucial role in the adjustment to IBD, especially within the first year of the diagnosis. AIMS: The primary aim of the study was to assess the stability of coping measures over time in children and parents following a new pediatric IBD diagnosis. The study also aimed to assess the impact of parental coping on parental healthcare resource utilization for children with newly diagnosed IBD, as well as the impact of parental coping on anxiety, depression, and quality of life in children with newly diagnosed IBD. METHODS: This was a prospective, longitudinal cohort study at Boston Children’s Hospital (BCH) that focused on children and adolescents with newly diagnosed IBD, as well as their parents. Patients and their parents were approached at the time they enrolled in the study and then again about 12 months later as part of a one-year follow-up. At both time points, they were asked to fill out various questionnaires about psychological functioning and answer other questions about medical care. RESULTS: The study identified and encountered 465 IBD patients, of which 126 were eligible for recruitment. There were 70 patients and families who signed a consent form for enrollment, 55 who fully or partially completed the questionnaires at baseline, and only 5 who also completed the questionnaires at follow-up. Due to the limited number of participants who completed the questionnaires at follow-up, no definitive conclusions could be drawn about the stability of coping measures over time. Parental anxiety, parental depression, frequent parental stress, and difficult parental stress were all found to be positively correlated with healthcare utilization and negatively correlated with the child’s quality of life. Parental anxiety, frequent parental stress, and difficult parental stress were all found to be positively correlated with the child’s anxiety. Parental depression, frequent parental stress, and difficult parental stress were all found to be positively correlated with the child’s depression. CONCLUSION: Preliminary findings suggest that poor parental coping leads to decreased child quality of life and increased healthcare utilization, child anxiety, and child depression. A larger sample size is needed to accurately evaluate the stability of coping measures over time. The next steps for this study involve further examination of the impact of parental coping and enrollment of more patients and families. Advisors/Committee Members: Spencer, Jean L. (advisor).

Subjects/Keywords: Medicine; Coping; Inflammatory bowel disease; Pediatric IBD

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APA (6^th Edition):

Collins, D. A. (2019). The impact of coping strategies exercised by children and their families on clinical management, disease outcome, and emotional well-being in children with newly diagnosed inflammatory bowel disease. (Masters Thesis). Boston University. Retrieved from http://hdl.handle.net/2144/36301

Chicago Manual of Style (16^th Edition):

Collins, Derek Alexander. “The impact of coping strategies exercised by children and their families on clinical management, disease outcome, and emotional well-being in children with newly diagnosed inflammatory bowel disease.” 2019. Masters Thesis, Boston University. Accessed March 04, 2021. http://hdl.handle.net/2144/36301.

MLA Handbook (7^th Edition):

Collins, Derek Alexander. “The impact of coping strategies exercised by children and their families on clinical management, disease outcome, and emotional well-being in children with newly diagnosed inflammatory bowel disease.” 2019. Web. 04 Mar 2021.

Vancouver:

Collins DA. The impact of coping strategies exercised by children and their families on clinical management, disease outcome, and emotional well-being in children with newly diagnosed inflammatory bowel disease. [Internet] [Masters thesis]. Boston University; 2019. [cited 2021 Mar 04]. Available from: http://hdl.handle.net/2144/36301.

Council of Science Editors:

Collins DA. The impact of coping strategies exercised by children and their families on clinical management, disease outcome, and emotional well-being in children with newly diagnosed inflammatory bowel disease. [Masters Thesis]. Boston University; 2019. Available from: http://hdl.handle.net/2144/36301

University of Manitoba

22. Rabbi, Mohammad. Catestatin (CTS) decreases intestinal inflammation in both acute and chronic models of murine colitis through the regulation of macrophages and/or gut microbiota.

Degree: Immunology, 2014, University of Manitoba

URL: http://hdl.handle.net/1993/32959

► Inflammatory bowel disease (IBD) is a chronic relapsing inflammatory disease of the gastrointestinal tract with unknown etiology. Although the incidence of IBD is increasing globally,… (more)

▼ Inflammatory bowel disease (IBD) is a chronic relapsing inflammatory disease of the gastrointestinal tract with unknown etiology. Although the incidence of IBD is increasing globally, there is no curative treatment for this complex disease. Therefore, revealing the etiology of IBD and identifying an optimal treatment is a major challenge. Mucosal changes in IBD are characterized by transmural inflammation and associated with an alteration in the prohormone chromogranin-A (CHGA) producing enterochromaffin (EC) cells. However, it is not clear whether the change plays any role in immune activation and in regulation of gut inflammation. The aim of this thesis was to identify the impact of catestatin (CTS), a bioactive peptide derived from the conserved C-terminal portion of CHGA on gut inflammation. In our first study, using an acute model of murine colitis and biopsy samples from ulcerative colitis (UC) patients, we demonstrated that CHGA and CTS were increased during inflammation. Moreover, we identified that administration of human (h) CTS significantly down- regulated gut inflammation. This down-regulation occurred via the modulation of pro-inflammatory cytokine secretion from the macrophage population. Although CTS is known as an antimicrobial peptide, there was no reported in vivo study demonstrating its antimicrobial impact in the gut. In our second study, we depicted that hCTS administration altered the gut microbiota composition, associated with a more prominent effect on the fecal microbiota than the mucosa-associated microbiota (MAM). In a separate study, we showed that the chemical agent (dextran sulfate sodium [DSS]), used in our colitis model, was also able to induce a microbial dysbiosis both in fecal and MAM samples. Finally, considering IBD as a relapsing disease of intestinal inflammation, we investigated the effect of hCTS in the context of intestinal inflammation reactivation using a chronic model of colitis mimicking the natural history of IBD. We observed that hCTS administration could down-regulate the reactivation of colitis through a down-regulation of the M1 but not the M2 macrophages and the gut microbiota. In conclusion, this Ph.D. thesis work revealed a novel anti-inflammatory effect of hCTS in gut inflammation which in the future might open novel therapeutic avenues for IBD. Advisors/Committee Members: Ghia, Jean-Eric (Immunology) (supervisor), Soussi Gounni, Abdel (Immunology) Mishra, Suresh (Physiology and Pathophysiology) Khafipour, Ehsan (Animal Science) Asselin, Claude (Université de Sherbrooke) (examiningcommittee).

Subjects/Keywords: Catestatin; Inflammatory bowel disease; Colitis; Macrophages

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APA (6^th Edition):

Rabbi, M. (2014). Catestatin (CTS) decreases intestinal inflammation in both acute and chronic models of murine colitis through the regulation of macrophages and/or gut microbiota. (Thesis). University of Manitoba. Retrieved from http://hdl.handle.net/1993/32959

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Rabbi, Mohammad. “Catestatin (CTS) decreases intestinal inflammation in both acute and chronic models of murine colitis through the regulation of macrophages and/or gut microbiota.” 2014. Thesis, University of Manitoba. Accessed March 04, 2021. http://hdl.handle.net/1993/32959.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Rabbi, Mohammad. “Catestatin (CTS) decreases intestinal inflammation in both acute and chronic models of murine colitis through the regulation of macrophages and/or gut microbiota.” 2014. Web. 04 Mar 2021.

Vancouver:

Rabbi M. Catestatin (CTS) decreases intestinal inflammation in both acute and chronic models of murine colitis through the regulation of macrophages and/or gut microbiota. [Internet] [Thesis]. University of Manitoba; 2014. [cited 2021 Mar 04]. Available from: http://hdl.handle.net/1993/32959.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Rabbi M. Catestatin (CTS) decreases intestinal inflammation in both acute and chronic models of murine colitis through the regulation of macrophages and/or gut microbiota. [Thesis]. University of Manitoba; 2014. Available from: http://hdl.handle.net/1993/32959

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

23. Hoti, Inva. Human mononuclear phagocytes and their control by IL-10 in health and inflammatory bowel disease.

Degree: PhD, 2019, Queen Mary, University of London

URL: http://qmro.qmul.ac.uk/xmlui/handle/123456789/55422 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.775318

► Intestinal macrophages, derived in part from monocytic precursors, are critical targets of IL-10, which prevents the development of colitis in mice. In humans, loss-of-function IL-10R… (more)

▼ Intestinal macrophages, derived in part from monocytic precursors, are critical targets of IL-10, which prevents the development of colitis in mice. In humans, loss-of-function IL-10R mutations cause early-onset inflammatory bowel disease (IBD). We aimed to test the hypothesis that IL-10 responsiveness in monocyte/macrophages is suboptimal in adult IBD patients even in the presence of functional IL-10 signalling. A novel assay was developed to measure the ability of IL-10 to inhibit LPS-induced TNF production by monocyte from blood or extracted from colonic biopsies. In healthy donors, monocyte subsets differed in their sensitivity to IL-10: classical monocytes were most sensitive and non-classical monocytes least, most likely due to lower levels of STAT3 availability and phosphorylation in response to IL-10. In IBD, circulating numbers of classical and intermediate monocytes were comparable to controls but non-classical monocytes were reduced. IL-10 was significantly less effective at inhibiting TNFα production by classical monocytes from IBD patients than controls (p=0.026), despite increased expression of IL-10Rα and IL-10-induced STAT3 phosphorylation. To determine the significance of this suboptimal response to IL-10 for monocyte-derived cells in the intestine, colonic CD14+ cells were analysed. Two populations were identified: CD14hi (P1) and CD14lo (P2) the latter of which were significantly increased in active Crohn's disease but not ulcerative colitis. Both populations produced TNFα in unstimulated cultures, and this response was significantly enhanced following LPS stimulation. The increase in TNFα production upon LPS stimulation was greater in P1 cells. Intestinal CD14+ cells were more sensitive to IL-10, in contrast to classical blood monocytes, TNF production by P1 and P2 cells, from non-IBD and inflamed IBD mucosa, was completely inhibited by 2ng/ml IL-10. Since inhibition was complete under these conditions it was not possible to draw conclusions about differences between health and disease; further studies with less IL-10 may be informative.

Subjects/Keywords: Immunobiology; inflammatory bowel disease; IL-10

10 more images…

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APA (6^th Edition):

Hoti, I. (2019). Human mononuclear phagocytes and their control by IL-10 in health and inflammatory bowel disease. (Doctoral Dissertation). Queen Mary, University of London. Retrieved from http://qmro.qmul.ac.uk/xmlui/handle/123456789/55422 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.775318

Chicago Manual of Style (16^th Edition):

Hoti, Inva. “Human mononuclear phagocytes and their control by IL-10 in health and inflammatory bowel disease.” 2019. Doctoral Dissertation, Queen Mary, University of London. Accessed March 04, 2021. http://qmro.qmul.ac.uk/xmlui/handle/123456789/55422 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.775318.

MLA Handbook (7^th Edition):

Hoti, Inva. “Human mononuclear phagocytes and their control by IL-10 in health and inflammatory bowel disease.” 2019. Web. 04 Mar 2021.

Vancouver:

Hoti I. Human mononuclear phagocytes and their control by IL-10 in health and inflammatory bowel disease. [Internet] [Doctoral dissertation]. Queen Mary, University of London; 2019. [cited 2021 Mar 04]. Available from: http://qmro.qmul.ac.uk/xmlui/handle/123456789/55422 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.775318.

Council of Science Editors:

Hoti I. Human mononuclear phagocytes and their control by IL-10 in health and inflammatory bowel disease. [Doctoral Dissertation]. Queen Mary, University of London; 2019. Available from: http://qmro.qmul.ac.uk/xmlui/handle/123456789/55422 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.775318

Queen Mary, University of London

24. Sanders, Theodore James. Production of retinoic acid by antigen presenting cells in the healthy and inflamed human intestine.

Degree: PhD, 2013, Queen Mary, University of London

URL: http://qmro.qmul.ac.uk/xmlui/handle/123456789/8648 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.667206

► Murine small intestinal CD103+ dendritic cells (DCs) produce retinoic acid (RA) through retinaldehyde dehydrogenase (RALDH) activity, thereby inducing ‘gut-homing’ α4β7 and CCR9 on T cells… (more)

▼ Murine small intestinal CD103+ dendritic cells (DCs) produce retinoic acid (RA) through retinaldehyde dehydrogenase (RALDH) activity, thereby inducing ‘gut-homing’ α4β7 and CCR9 on T cells they activate, enhancing TGF-β-mediated induction of Foxp3+ regulatory T cells and suppressing induction of pro-inflammatory TH17 cells. RALDH activity of CD103+ DCs is reduced in mouse models of inflammatory bowel disease (IBD) but the role of RALDH activity in human intestinal DCs in the pathogenesis of IBD is undefined. This project aimed to determine the influence of inflammation on RALDH activity of antigen presenting cell (APC) subsets including CD103+ DCs within human distal intestinal mucosa. RALDH activity was identified by Aldefluor assay in intestinal DCs (CD103+ and CD103- subsets) alongside ALDH1A2 expression in healthy controls. In contrast with mouse models, RALDH activity was not reduced in CD103+ DCs from IBD patients. An increased frequency of CD14+ macrophages (MФ) of IBD patients displayed ALDH1A1-associated RALDH activity compared with healthy controls. Blood CD14+ monocytes, putative precursors of intestinal CD14+ MФ, of healthy controls and IBD patients displayed ALDH1A1-associated RALDH activity indicating RALDH is systemically acquired by monocytes and upregulated within the mucosa of IBD patients, or alternatively that RALDH+ monocytes are selectively recruited in IBD. In vitro, inhibition of RA receptor-α signalling blocked GM-CSF-mediated differentiation of TNFα-producing pro-inflammatory RALDH+ CD14+ MФ from monocytes, consistent with enhanced RALDH activity of intestinal CD14+ MФ in IBD supporting a pro-inflammatory phenotype. Soluble intestinal mediators including prostaglandin E2 suppressed RALDH activity of MoDCs in vitro, whilst mediators from inflamed IBD mucosa conditioned MoDCs to imprint enhanced levels of α4β7 expression on naive CD4+ T cells independent of RALDH activity. This study provides the first systematic analysis of RALDH activity in human intestinal APCs and indicates important distinctions between mouse models and human IBD.

Subjects/Keywords: 616.3; Medicine; Inflammatory bowel disease; Retinaldehyde dehydrogenase

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APA (6^th Edition):

Sanders, T. J. (2013). Production of retinoic acid by antigen presenting cells in the healthy and inflamed human intestine. (Doctoral Dissertation). Queen Mary, University of London. Retrieved from http://qmro.qmul.ac.uk/xmlui/handle/123456789/8648 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.667206

Chicago Manual of Style (16^th Edition):

Sanders, Theodore James. “Production of retinoic acid by antigen presenting cells in the healthy and inflamed human intestine.” 2013. Doctoral Dissertation, Queen Mary, University of London. Accessed March 04, 2021. http://qmro.qmul.ac.uk/xmlui/handle/123456789/8648 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.667206.

MLA Handbook (7^th Edition):

Sanders, Theodore James. “Production of retinoic acid by antigen presenting cells in the healthy and inflamed human intestine.” 2013. Web. 04 Mar 2021.

Vancouver:

Sanders TJ. Production of retinoic acid by antigen presenting cells in the healthy and inflamed human intestine. [Internet] [Doctoral dissertation]. Queen Mary, University of London; 2013. [cited 2021 Mar 04]. Available from: http://qmro.qmul.ac.uk/xmlui/handle/123456789/8648 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.667206.

Council of Science Editors:

Sanders TJ. Production of retinoic acid by antigen presenting cells in the healthy and inflamed human intestine. [Doctoral Dissertation]. Queen Mary, University of London; 2013. Available from: http://qmro.qmul.ac.uk/xmlui/handle/123456789/8648 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.667206

Queen Mary, University of London

25. Bell, Iona Maree. The role of membrane Tumour Necrosis Factor Alpha in the function and efficacy of anti-tumour necrosis factor antibodies in inflammatory bowel disease.

Degree: PhD, 2018, Queen Mary, University of London

URL: http://qmro.qmul.ac.uk/xmlui/handle/123456789/43945 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.786335

► Tumour Necrosis Factor Alpha (TNFα) is central to the immunopathogenesis of inflammatory bowel disease. It is initially expressed on the cell surface as a trimer,… (more)

Subjects/Keywords: Inflammatory Bowel Disease; Tumour Necrosis Factor Alpha

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APA (6^th Edition):

Bell, I. M. (2018). The role of membrane Tumour Necrosis Factor Alpha in the function and efficacy of anti-tumour necrosis factor antibodies in inflammatory bowel disease. (Doctoral Dissertation). Queen Mary, University of London. Retrieved from http://qmro.qmul.ac.uk/xmlui/handle/123456789/43945 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.786335

Chicago Manual of Style (16^th Edition):

Bell, Iona Maree. “The role of membrane Tumour Necrosis Factor Alpha in the function and efficacy of anti-tumour necrosis factor antibodies in inflammatory bowel disease.” 2018. Doctoral Dissertation, Queen Mary, University of London. Accessed March 04, 2021. http://qmro.qmul.ac.uk/xmlui/handle/123456789/43945 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.786335.

MLA Handbook (7^th Edition):

Bell, Iona Maree. “The role of membrane Tumour Necrosis Factor Alpha in the function and efficacy of anti-tumour necrosis factor antibodies in inflammatory bowel disease.” 2018. Web. 04 Mar 2021.

Vancouver:

Bell IM. The role of membrane Tumour Necrosis Factor Alpha in the function and efficacy of anti-tumour necrosis factor antibodies in inflammatory bowel disease. [Internet] [Doctoral dissertation]. Queen Mary, University of London; 2018. [cited 2021 Mar 04]. Available from: http://qmro.qmul.ac.uk/xmlui/handle/123456789/43945 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.786335.

Council of Science Editors:

Bell IM. The role of membrane Tumour Necrosis Factor Alpha in the function and efficacy of anti-tumour necrosis factor antibodies in inflammatory bowel disease. [Doctoral Dissertation]. Queen Mary, University of London; 2018. Available from: http://qmro.qmul.ac.uk/xmlui/handle/123456789/43945 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.786335

University of Edinburgh

26. Phillips, Anne Mairead. Investigation of the phenotypic and genotypic determinants of disease susceptibility and progression in Crohn's Disease.

Degree: PhD, 2011, University of Edinburgh

URL: http://hdl.handle.net/1842/9473

► The inflammatory bowel diseases (IBD), encompassing Crohn’s disease (CD) and ulcerative colitis (UC), are chronic inflammatory disorders of the gastrointestinal tract. Their aetiology is not… (more)

Subjects/Keywords: 616.3; Crohn's disease; inflammatory bowel diseases

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APA (6^th Edition):

Phillips, A. M. (2011). Investigation of the phenotypic and genotypic determinants of disease susceptibility and progression in Crohn's Disease. (Doctoral Dissertation). University of Edinburgh. Retrieved from http://hdl.handle.net/1842/9473

Chicago Manual of Style (16^th Edition):

Phillips, Anne Mairead. “Investigation of the phenotypic and genotypic determinants of disease susceptibility and progression in Crohn's Disease.” 2011. Doctoral Dissertation, University of Edinburgh. Accessed March 04, 2021. http://hdl.handle.net/1842/9473.

MLA Handbook (7^th Edition):

Phillips, Anne Mairead. “Investigation of the phenotypic and genotypic determinants of disease susceptibility and progression in Crohn's Disease.” 2011. Web. 04 Mar 2021.

Vancouver:

Phillips AM. Investigation of the phenotypic and genotypic determinants of disease susceptibility and progression in Crohn's Disease. [Internet] [Doctoral dissertation]. University of Edinburgh; 2011. [cited 2021 Mar 04]. Available from: http://hdl.handle.net/1842/9473.

Council of Science Editors:

Phillips AM. Investigation of the phenotypic and genotypic determinants of disease susceptibility and progression in Crohn's Disease. [Doctoral Dissertation]. University of Edinburgh; 2011. Available from: http://hdl.handle.net/1842/9473

27. PIGOTT, MARIA THERESE. Intestinal targeting of small molecule MMP and TGR5 ligands for inflammatory bowel disease.

Degree: School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2018, Trinity College Dublin

URL: http://hdl.handle.net/2262/84983

► The aetiology of inflammatory bowel disease (IBD) is incompletely understood but it is generally accepted to involve a dysregulated intestinal immune response to commensal microbiota… (more)

▼ The aetiology of inflammatory bowel disease (IBD) is incompletely understood but it is generally accepted to involve a dysregulated intestinal immune response to commensal microbiota and an increase in intestinal permeability. Matrix metalloproteinases (MMPs), MMP-9 (gelatinase B) in particular, are implicated in this compromise of intestinal barrier structure and have further roles in the potentiation and augmentation of disease. Takeda G-protein coupled receptor 5 (TGR5), a bile acid receptor, is also involved in maintenance of intestinal barrier integrity and there is evidence to suggest that both these targets are accessible to modulators confined to the gut lumen. Expressed in many tissues and cell types and involved in many physiological processes, the potential of MMP and TGR5 modulators has been limited by unwanted off-target effects. We proposed that small molecule ligands designed to be confined to the gastrointestinal lumen through judicious modification of physicochemical properties could achieve non-systemic effects. Suppression of oral absorption potential of an established gelatinase inhibitory scaffold was pursued by synthetic strategies to increase molecular weight and/or polarity including preparation of a dimer linked by a short PEG chain or introduction of a permanent charge. Bulky conjugates of an MMP inhibitor and lithocholic acid (LCA), the most potent endogenous bile acid agonist at TGR5, were also prepared. By virtue of their high molecular weight, such conjugates would be expected to have limited absorption potential and we hoped to retain activity at both targets. Compound 53, a permanently positively charged barbiturate-based gelatinase inhibitor was a potent inhibitor of recombinant human MMP-9 as measured by fluorogenic assay and an uptake assay in Caco-2 cells indicated that it was a poor candidate for passive uptake. It was chosen for evaluation in a DSS mouse model of colitis to test the hypothesis that disease modifying effects can be achieved by inhibition of apically secreted gelatinases. Compound 53 treatment reduced the severity of DSS-induced colitis in mice and the disease activity index (DAI) scores of the treated group were significantly lower than the DSS group. PCR analysis of the retained colon samples indicated that the pro-inflammatory cytokines TNF-?, IL-1? and IL-6 were downregulated at gene level in the treated group compared to the DSS control group and these downregulations were statistically significant. The MMP-9 inhibitor ? TGR5 agonist conjugates retained potent MMP-9 inhibition but activation of TGR5 showed tighter structural specificity than expected. Some compounds of the series caused accumulation of cAMP, the downstream second messenger of TGR5 activation, in human enterendocrine NCI-H716 cells but potency was much lower than LCA. It is yet unknown if this level of activity could exert a functional effect in the context of a gut confined agent in appropriate animal models. This work contributed to our knowledge of binding at the human TGR5 receptor, its… Advisors/Committee Members: Gilmer, John.

Subjects/Keywords: matrix metalloproteinases; TGR5; inflammatory bowel disease; MMPs

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APA (6^th Edition):

PIGOTT, M. T. (2018). Intestinal targeting of small molecule MMP and TGR5 ligands for inflammatory bowel disease. (Thesis). Trinity College Dublin. Retrieved from http://hdl.handle.net/2262/84983

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

PIGOTT, MARIA THERESE. “Intestinal targeting of small molecule MMP and TGR5 ligands for inflammatory bowel disease.” 2018. Thesis, Trinity College Dublin. Accessed March 04, 2021. http://hdl.handle.net/2262/84983.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

PIGOTT, MARIA THERESE. “Intestinal targeting of small molecule MMP and TGR5 ligands for inflammatory bowel disease.” 2018. Web. 04 Mar 2021.

Vancouver:

PIGOTT MT. Intestinal targeting of small molecule MMP and TGR5 ligands for inflammatory bowel disease. [Internet] [Thesis]. Trinity College Dublin; 2018. [cited 2021 Mar 04]. Available from: http://hdl.handle.net/2262/84983.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

PIGOTT MT. Intestinal targeting of small molecule MMP and TGR5 ligands for inflammatory bowel disease. [Thesis]. Trinity College Dublin; 2018. Available from: http://hdl.handle.net/2262/84983

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Ottawa

28. Elten, Michael. The Association Between Environmental Factors and the Risk of Paediatric Inflammatory Bowel Disease .

Degree: 2020, University of Ottawa

URL: http://hdl.handle.net/10393/40215

► Background: The incidence of inflammatory bowel disease (IBD) in children is increasing. Environmental factors related to industrialization, including increased levels of air pollution and reduced… (more)

Subjects/Keywords: Air pollution; Greenspace; Inflammatory bowel disease; Epidemiology

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Elten, M. (2020). The Association Between Environmental Factors and the Risk of Paediatric Inflammatory Bowel Disease . (Thesis). University of Ottawa. Retrieved from http://hdl.handle.net/10393/40215

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Elten, Michael. “The Association Between Environmental Factors and the Risk of Paediatric Inflammatory Bowel Disease .” 2020. Thesis, University of Ottawa. Accessed March 04, 2021. http://hdl.handle.net/10393/40215.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Elten, Michael. “The Association Between Environmental Factors and the Risk of Paediatric Inflammatory Bowel Disease .” 2020. Web. 04 Mar 2021.

Vancouver:

Elten M. The Association Between Environmental Factors and the Risk of Paediatric Inflammatory Bowel Disease . [Internet] [Thesis]. University of Ottawa; 2020. [cited 2021 Mar 04]. Available from: http://hdl.handle.net/10393/40215.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Elten M. The Association Between Environmental Factors and the Risk of Paediatric Inflammatory Bowel Disease . [Thesis]. University of Ottawa; 2020. Available from: http://hdl.handle.net/10393/40215

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Melbourne

29. Iyngkaran, Guruparan. Indigenous Australians have a distinctive gut microbial profile compared to Caucasian controls and patients with inflammatory bowel disease.

Degree: 2015, University of Melbourne

URL: http://hdl.handle.net/11343/58623

► The aetiology of inflammatory bowel disease (IBD) is yet unknown but it is thought to occur in a genetically predisposed individual following an environmental trigger.… (more)

▼ The aetiology of inflammatory bowel disease (IBD) is yet unknown but it is thought to occur in a genetically predisposed individual following an environmental trigger. The incidence of IBD has risen rapidly in industrialised nations but remains low in developing countries. In Canada, the incidence of IBD is high in their urban population but extremely low in their Indigenous populations. This has led to the “hygiene hypothesis”, which postulates that a reduced exposure to antigens due to urbanisation may lead to an increase in immune mediated diseases such as IBD. Many studies have shown that patients with active IBD have changes in gut microbiota or “dysbiosis”. My first hypothesis was that IBD is rare in Indigenous Australians (IA). I confirmed this by setting up an IBD database at the Royal Darwin Hospital in the Northern Territory (NT) and by interrogating the hospital records from 2007-2014. The NT has a large Indigenous population with a third of its population being Indigenous. The IBD database revealed that the prevalence of IBD in Indigenous Australians in the NT is 5/100,000 compared to 186/100,000 in the non- Indigenous population. My second hypothesis was that IA have a distinct gut microbial profile that may account for their low incidence of IBD. I utilised 16S amplicon based techniques to study gut microbial profiles in IA, Caucasian controls and IBD patients. Whilst it is difficult to prove causality, I demonstrated that gut microbial profiles of IA are highly abundant in Prevotella sp and lactic acid producing bacteria, and are different from Caucasian controls and IBD patients. The gut microbiota of IA are also enriched in enzymes that are involved in propionate production, a food source for colonocytes. My third hypothesis was that the gut mucosa of IA would have a higher expression of anti-inflammatory cytokines. I showed, through quantitative real-time PCR, that there was a trend in increased expression of Thymic Stromal Lymphopoeitin (TSLP) in IA. TSLP is a cytokine that is involved in preventing helminthic infections and has been shown in mouse models to confer some protection to IBD. Patients with IBD showed a typical pro-inflammatory cytokine expression pattern. My results demonstrate that IA, who have a low incidence of IBD, have a distinctive gut microbial profile and a trend in increase of the cytokine TSLP. This may be directly related to their traditional lifestyle. Testing their gut microbial profiles in mouse models of colitis may reveal if their gut microbiota are truly protective against IBD.

Subjects/Keywords: inflammatory bowel disease; microbiota; indigenous; epidemiology

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Iyngkaran, G. (2015). Indigenous Australians have a distinctive gut microbial profile compared to Caucasian controls and patients with inflammatory bowel disease. (Doctoral Dissertation). University of Melbourne. Retrieved from http://hdl.handle.net/11343/58623

Chicago Manual of Style (16^th Edition):

Iyngkaran, Guruparan. “Indigenous Australians have a distinctive gut microbial profile compared to Caucasian controls and patients with inflammatory bowel disease.” 2015. Doctoral Dissertation, University of Melbourne. Accessed March 04, 2021. http://hdl.handle.net/11343/58623.

MLA Handbook (7^th Edition):

Iyngkaran, Guruparan. “Indigenous Australians have a distinctive gut microbial profile compared to Caucasian controls and patients with inflammatory bowel disease.” 2015. Web. 04 Mar 2021.

Vancouver:

Iyngkaran G. Indigenous Australians have a distinctive gut microbial profile compared to Caucasian controls and patients with inflammatory bowel disease. [Internet] [Doctoral dissertation]. University of Melbourne; 2015. [cited 2021 Mar 04]. Available from: http://hdl.handle.net/11343/58623.

Council of Science Editors:

Iyngkaran G. Indigenous Australians have a distinctive gut microbial profile compared to Caucasian controls and patients with inflammatory bowel disease. [Doctoral Dissertation]. University of Melbourne; 2015. Available from: http://hdl.handle.net/11343/58623

University of Melbourne

30. Jackson, Belinda Deborah. An integrated eHealth strategy to optimise outpatient disease and psychological management in inflammatory bowel disease.

Degree: 2019, University of Melbourne

URL: http://hdl.handle.net/11343/221851

► The increasing incidence of inflammatory bowel disease (IBD) over the past decade has resulted in increased health care resource utilisation and longer specialist outpatient waiting… (more)

▼ The increasing incidence of inflammatory bowel disease (IBD) over the past decade has resulted in increased health care resource utilisation and longer specialist outpatient waiting lists. IBD is associated with an increased prevalence of psychological morbidity and adversely affects quality of life, societal interaction and functioning. Electronic-health or ‘eHealth’ technologies incorporating self-management strategies to manage patients remotely such as telemedicine, web-based interventions, and smart-phone applications may offer a solution to streamline outpatient management, by detecting earlier changes in patient well-being (disease activity, medication status and psychological health) and providing greater access to personalised care in real-time. However, whether eHealth technologies offer any significant benefit over traditional outpatient based IBD care remains to be proven. This thesis encompasses a framework and the design of a decision support tool which aims to improve the outpatient management of IBD patients by proving that eHealth monitoring of patients with mild-to-moderate ulcerative colitis, stratified for disease activity and psychological distress and treated according to a fixed regime of eHealth directed self-management, is an effective model of care compared with IBD clinic-led outpatient management. A colloquium was initially held to obtain key stakeholders’ perspectives on the role of an eHealth tool to facilitate decision support for IBD. Retrospective studies were then undertaken to establish the extent to which gastroenterologists adhere to evidence based international guidelines in clinical practice. A cost analysis study was conducted to describe the current cost of care and to compare the costs associated with treating active disease compared to disease in remission. A cross-sectional study was then undertaken to establish the relationship between patient-reported outcomes and disease activity. Patient perspectives regarding the potential value of an eHealth intervention for outpatient IBD management were then explored. Finally, clinical algorithms were developed for disease activity, psychological wellbeing and preventive care and incorporated into a decision support tool which was assessed for feasibility, usability and acceptability compared to standard IBD care. In summary, this is the first prospective study to demonstrate that an eHealth tool to facilitate decision support significantly improves the delivery of quality care and promotes shared decision-making in patients with mild-to-moderate ulcerative colitis.

Subjects/Keywords: Quality of care; eHealth; inflammatory bowel disease

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Jackson, B. D. (2019). An integrated eHealth strategy to optimise outpatient disease and psychological management in inflammatory bowel disease. (Doctoral Dissertation). University of Melbourne. Retrieved from http://hdl.handle.net/11343/221851

Chicago Manual of Style (16^th Edition):

Jackson, Belinda Deborah. “An integrated eHealth strategy to optimise outpatient disease and psychological management in inflammatory bowel disease.” 2019. Doctoral Dissertation, University of Melbourne. Accessed March 04, 2021. http://hdl.handle.net/11343/221851.

MLA Handbook (7^th Edition):

Jackson, Belinda Deborah. “An integrated eHealth strategy to optimise outpatient disease and psychological management in inflammatory bowel disease.” 2019. Web. 04 Mar 2021.

Vancouver:

Jackson BD. An integrated eHealth strategy to optimise outpatient disease and psychological management in inflammatory bowel disease. [Internet] [Doctoral dissertation]. University of Melbourne; 2019. [cited 2021 Mar 04]. Available from: http://hdl.handle.net/11343/221851.

Council of Science Editors:

Jackson BD. An integrated eHealth strategy to optimise outpatient disease and psychological management in inflammatory bowel disease. [Doctoral Dissertation]. University of Melbourne; 2019. Available from: http://hdl.handle.net/11343/221851

Open Access Theses and Dissertations