subject:(Immunoglobulin)

University of New Mexico

1. Wang, Xinxin. Lymphocyte evolution and ontogeny in non-eutherian mammals.

Degree: UNM Biology Department, 2012, University of New Mexico

URL: https://digitalrepository.unm.edu/biol_etds/109

► Based on their different reproductive modes and evolutionary history, extant mammals are divided into three lineages: eutherians, marsupials and monotremes. Marsupials are the closest relatives… (more)

▼ Based on their different reproductive modes and evolutionary history, extant mammals are divided into three lineages: eutherians, marsupials and monotremes. Marsupials are the closest relatives to eutherians. They are born immune-incompetent. The characteristic that they develop their immune system postnatally makes them unique models to study newborn immune development and maternal immunology. As monotremes comprises the basal lineage of mammals, the study of monotreme immunology will provide unique insights regarding the origin of the mammalian immune system. Unfortunately, compared to our in-depth knowledge of eutherian immunology, especially humans and mice, knowledge of marsupial and monotreme immunology is scarce. The goal of the first part of this research was to investigate the development of immune-competence in a model marsupial, the gray short-tailed opossum, Monodelphis domestica. This research specifically looked at the ontogeny of B cells with emphasis on diversity of immunoglobulin genes during postnatal development. It takes advantage of genomic resources available for the opossum and a captive colony at the UNM Biology Department. To achieve these goals, the content and genomic organization of Ig heavy chain and light chain loci was determined. Opossum Ig heavy chain are of low germ-line diversity while light chains have high germ-line diversity. This suggests that opossums rely more on light chains than heavy chains for repertoire diversity (Wang et al. 2009). Using the detailed genomic information available of Ig loci, the timing of B cell ontogeny and Ig repertoire diversity was then determined. Opossum newborns start heavy chain VDJ recombination within the first 24 hours postpartum. The expression of the surrogate L chains occurs at day 6 postnatally. The subsequent rearrangement of the Ig\u03bb and Ig\u03ba L chain genes occur at days 7 and 8 postnatal, respectively. The diversity of early B cell H chains is limited and reduced in N region additions, as has been seen in fetal humans and mice, but lacks bias in the V, D and J segments used. Different from H chains, L chains develop much more diverse VJ recombinations and high IgL repertoire diversity when first expressed. Collectively the results demonstrate that B cell development is entirely postnatal in the opossum. The earliest time-point that an opossum has mature B cells is at the starting the second week of life (Wang et al. in preparation). These results are consistent with earlier work demonstrating that most marsupial species, including opossums are unable to generate an antibody response until the second week. A second goal of my research was the characterization of a novel T cell receptor in the duckbill platypus Ornithorhynchus anatinus. Although different from the previous goal, it nonetheless uses a non-eutherian model to address broader questions regarding immunoglobulin and T cell receptor gene evolution. TCRμ is a new T cell receptor that was first identified in marsupials and does not exist in eutherians (Parra et… Advisors/Committee Members: MILLER, ROBERT, LOKER, ERIC, MILLER, ROBERT, Adema, Coenraad, Criscitiello, Michael.

Subjects/Keywords: Immunoglobulin

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APA (6^th Edition):

Wang, X. (2012). Lymphocyte evolution and ontogeny in non-eutherian mammals. (Doctoral Dissertation). University of New Mexico. Retrieved from https://digitalrepository.unm.edu/biol_etds/109

Chicago Manual of Style (16^th Edition):

Wang, Xinxin. “Lymphocyte evolution and ontogeny in non-eutherian mammals.” 2012. Doctoral Dissertation, University of New Mexico. Accessed March 01, 2021. https://digitalrepository.unm.edu/biol_etds/109.

MLA Handbook (7^th Edition):

Wang, Xinxin. “Lymphocyte evolution and ontogeny in non-eutherian mammals.” 2012. Web. 01 Mar 2021.

Vancouver:

Wang X. Lymphocyte evolution and ontogeny in non-eutherian mammals. [Internet] [Doctoral dissertation]. University of New Mexico; 2012. [cited 2021 Mar 01]. Available from: https://digitalrepository.unm.edu/biol_etds/109.

Council of Science Editors:

Wang X. Lymphocyte evolution and ontogeny in non-eutherian mammals. [Doctoral Dissertation]. University of New Mexico; 2012. Available from: https://digitalrepository.unm.edu/biol_etds/109

Nelson Mandela Metropolitan University

2. Bowles, Sandra Lyn. An investigation of IgE regulation by recombinant soluble IgE receptors and co-receptors in human cell culture models.

Degree: Faculty of Science, 2010, Nelson Mandela Metropolitan University

URL: http://hdl.handle.net/10948/1231

► Type I hypersensitivities are mediated by the IgE antibody. The effector functions and synthesis of IgE result from interactions with a network of proteins that… (more)

▼ Type I hypersensitivities are mediated by the IgE antibody. The effector functions and synthesis of IgE result from interactions with a network of proteins that include a high affinity (FcRIα) and a low affinity (CD23, FcRII) Fc receptor in conjunction with the B lymphocyte receptor, CD21. CD23 is a multifunctional type II transmembrane protein that binds its known ligands through its ectodomain either as a membrane-bound or soluble receptor generated in vivo by specific proteolytic cleavages. IgE production is primarily regulated by interactions between IgE, CD23 and CD21. Despite its importance for development of strategies to limit hypersensitivity, precise information about the molecular interactions remains limited. During this study, I engineered, expressed and purified from bacteria three soluble human CD23 fragments that are normally formed in vivo and shed from the cell surface (1) derCD23, amino acids 156-298 (2) sCD23, amino acids 150-321 and (3) the entire ectodomain, exCD23, amino acids 48-321 to examine the comparative binding of recombinant human CD21 SCR 1-2 and native human IgE to these fragments. Gel filtration HPLC revealed that derCD23 and sCD23 were monomeric whereas exCD23 assembled as a heterogeneous mixture that included trimers and monomers. At the concentrations utilized, CD23 fragments sCD23 and exCD23 bound CD21 with similar affinity, whereas interaction between derCD23 and CD21 was minimal when analyzed by surface plasmon resonance (SPR) spectroscopy. These findings suggest that penultimate “tail” amino acids between 298 and 321 stabilize CD21 attachment, although it cannot be ruled out, the region between Met 150 and Ser 156 may also play a role in binding CD21 SCR 1-2. In contrast, there is a progressive increment in the affinity of soluble fragments (exCD23>sCD23>derCD23) for IgE, upon increasing length of the proximal CD23 “stalk” domain. These findings highlight the differences in both the structural basis and affinity of the three physiological fragments of human CD23 for the ligands CD21 and IgE and underscore the complexity of CD23-mediated regulatory networks. It was found that B-cells only make up ~5% of the PBMC population, and that these cells were able to be activated, via STAT-6 phosphorylation, to enter class switch recombination (CSR) by the addition of switch factors (IL-4 and anti-CD40). Titration experiments dictated that 25 ng/mL of CD23 was the most efficient concentration to up-regulate IgE synthesis in PBMCs; furthermore, soluble CD23 proteins were incubated with PBMCs in the presence and absence of CD21 SCR 1-2 to investigate the effect that these recombinant proteins have on IgE synthesis. Results showed that the influence of recombinant proteins (both CD23 and CD21) on IgE synthesis was slight. It was shown that while derCD23 had no significant effect, monomeric sCD23 down-regulated, and the mixture of monomeric and oligomeric exCD23 up-regulated IgE synthesis. On addition of CD21 SCR 1-2 to the cells switched and treated with soluble CD23, it was found that in…

Subjects/Keywords: Immunoglobulin E; Allergy

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APA (6^th Edition):

Bowles, S. L. (2010). An investigation of IgE regulation by recombinant soluble IgE receptors and co-receptors in human cell culture models. (Thesis). Nelson Mandela Metropolitan University. Retrieved from http://hdl.handle.net/10948/1231

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Bowles, Sandra Lyn. “An investigation of IgE regulation by recombinant soluble IgE receptors and co-receptors in human cell culture models.” 2010. Thesis, Nelson Mandela Metropolitan University. Accessed March 01, 2021. http://hdl.handle.net/10948/1231.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Bowles, Sandra Lyn. “An investigation of IgE regulation by recombinant soluble IgE receptors and co-receptors in human cell culture models.” 2010. Web. 01 Mar 2021.

Vancouver:

Bowles SL. An investigation of IgE regulation by recombinant soluble IgE receptors and co-receptors in human cell culture models. [Internet] [Thesis]. Nelson Mandela Metropolitan University; 2010. [cited 2021 Mar 01]. Available from: http://hdl.handle.net/10948/1231.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Bowles SL. An investigation of IgE regulation by recombinant soluble IgE receptors and co-receptors in human cell culture models. [Thesis]. Nelson Mandela Metropolitan University; 2010. Available from: http://hdl.handle.net/10948/1231

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

3. Yadav, Ramdayal. Serum immunoglobulin profile in malaria infection; -.

Degree: Medicine, 1999, Bundelkhand University

URL: http://shodhganga.inflibnet.ac.in/handle/10603/11685

None

Bibliography p.I -IX , Appendices p.I -III given etc..

Advisors/Committee Members: Sharma, VK.

Subjects/Keywords: Immunoglobulin; malaria

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APA (6^th Edition):

Yadav, R. (1999). Serum immunoglobulin profile in malaria infection; -. (Thesis). Bundelkhand University. Retrieved from http://shodhganga.inflibnet.ac.in/handle/10603/11685

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Yadav, Ramdayal. “Serum immunoglobulin profile in malaria infection; -.” 1999. Thesis, Bundelkhand University. Accessed March 01, 2021. http://shodhganga.inflibnet.ac.in/handle/10603/11685.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Yadav, Ramdayal. “Serum immunoglobulin profile in malaria infection; -.” 1999. Web. 01 Mar 2021.

Vancouver:

Yadav R. Serum immunoglobulin profile in malaria infection; -. [Internet] [Thesis]. Bundelkhand University; 1999. [cited 2021 Mar 01]. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/11685.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Yadav R. Serum immunoglobulin profile in malaria infection; -. [Thesis]. Bundelkhand University; 1999. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/11685

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Texas Southwestern Medical Center

4. Pyle, David Michael, 1984-. Regulation of Human Monocyte Function by Cross-Linking of Immunoglobulin E.

Degree: 2013, University of Texas Southwestern Medical Center

URL: http://hdl.handle.net/2152.5/ETD-UTSWMED-2015-05-130

► Cross-linking of IgE by allergen triggers many cellular processes that drive allergic disease. While the role of IgE in mediating allergic responses is best described… (more)

▼ Cross-linking of IgE by allergen triggers many cellular processes that drive allergic disease. While the role of IgE in mediating allergic responses is best described on basophils and mast cells, expression of the high-affinity IgE receptor on other innate immune cells, including monocytes, suggests that it may impact the function of these cells in allergic environments. Exacerbations of allergic disease have been associated with allergen exposure as well as viral and bacterial infection, but the mechanisms of these phenomena are not well understood. Monocytes are recruited to sites of inflammation in both allergic disease and infection, serving a number of important functions, including cytokine secretion, phagocytosis, and stimulation of adaptive immune responses. However, the impact of IgE cross-linking on monocyte functions is poorly understood. To determine how IgE cross-linking affects monocyte phenotype and function I isolated primary human monocytes from blood samples and stimulated them in the presence or absence of a cross-linking anti-IgE antibody. My studies reveal that IgE cross-linking induces up regulation of CD14, an important component of inflammatory responses. IgE cross-linking on monocytes also induces secretion of inflammatory cytokines - including tumor necrosis factor α, and interleukin-1, -6, and -23 - as well as autoregulatory interleukin-10. These inflammatory responses to IgE cross-linking are enhanced in monocytes from individuals with elevated serum IgE concentration, compared to monocytes from individuals with normal IgE concentration. In contrast, IgE cross-linking suppresses expression of an important mediator of phagocytosis, CD64. Indeed, IgE cross-linking specifically impairs monocyte phagocytic function without disrupting the capacity of monocytes to kill intracellular bacteria. IgE cross-linking also reduces expression of several surface molecules associated with antigen presentation and inhibits virus-induced up regulation of these molecules. Furthermore, IgE cross-linking during virus exposure suppresses monocyte-driven differentiation of type 1 helper T cells. My findings suggest that IgE cross-linking on monocytes may contribute to allergic disease as well as pathogen-associated exacerbations of disease by three mechanisms: 1) enhancing detrimental inflammatory responses in a serum IgE-dependent manner, 2) concomitantly crippling phagocytosis, a primary mechanism utilized by these cells to resolve inflammation, and 3) suppressing stimulation of appropriate T cell responses in response to infection. Advisors/Committee Members: Farrar, J. David, Gill, Michelle A., Gruchalla, Rebecca S., Yarovinsky, Felix, Kahn, Jeffrey.

Subjects/Keywords: Immunoglobulin E; Monocytes; Phagocytosis

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APA (6^th Edition):

Pyle, David Michael, 1. (2013). Regulation of Human Monocyte Function by Cross-Linking of Immunoglobulin E. (Thesis). University of Texas Southwestern Medical Center. Retrieved from http://hdl.handle.net/2152.5/ETD-UTSWMED-2015-05-130

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Pyle, David Michael, 1984-. “Regulation of Human Monocyte Function by Cross-Linking of Immunoglobulin E.” 2013. Thesis, University of Texas Southwestern Medical Center. Accessed March 01, 2021. http://hdl.handle.net/2152.5/ETD-UTSWMED-2015-05-130.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Pyle, David Michael, 1984-. “Regulation of Human Monocyte Function by Cross-Linking of Immunoglobulin E.” 2013. Web. 01 Mar 2021.

Vancouver:

Pyle, David Michael 1. Regulation of Human Monocyte Function by Cross-Linking of Immunoglobulin E. [Internet] [Thesis]. University of Texas Southwestern Medical Center; 2013. [cited 2021 Mar 01]. Available from: http://hdl.handle.net/2152.5/ETD-UTSWMED-2015-05-130.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Pyle, David Michael 1. Regulation of Human Monocyte Function by Cross-Linking of Immunoglobulin E. [Thesis]. University of Texas Southwestern Medical Center; 2013. Available from: http://hdl.handle.net/2152.5/ETD-UTSWMED-2015-05-130

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of New South Wales

5. Kidd, Marie. The effect of genetic variation at the immunoglobulin heavy chain variable region gene loci on biases in the generation of the human primary antibody repertoire.

Degree: UNSW, 2017, University of New South Wales

URL: http://handle.unsw.edu.au/1959.4/58449 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:46056/SOURCE02?view=true

► The human primary antibody repertoire must be incredibly diverse in order to combat a constantly evolving array of pathogens. Random events contribute to the repertoire… (more)

▼ The human primary antibody repertoire must be incredibly diverse in order to combat a constantly evolving array of pathogens. Random events contribute to the repertoire diversity that is created within an individual on a daily basis. Similarly, much of the genetic variation existing between individuals and populations at the immunoglobulin loci has been generated via stochastic processes. However, deviations from randomness have been detected both during the processes that generate the primary repertoire within an individual and during the evolution of the immunoglobulin genes. This complex set of events and genes has been notoriously difficult to investigate. However, next-generation sequencing technologies have recently allowed the creation of datasets containing thousands of rearranged sequences. This has allowed great insight into the events taking place during the formation of a B cell in the bone marrow and into genetic diversity within and between human populations. The information contained in such large datasets allows many questions to be asked. Preferential IGHD-IGHJ pairing has been reported, but the mechanism involved is unclear. Using very large datasets and the fact that VDJ rearrangement is an intrachromosomal event, complex patterns were detected. These patterns changed in a predictable way in individuals carrying IGHD deletion polymorphisms, suggesting a strong positional influence and the involvement of other factors too. Results also suggest that the recombinase associates with an IGHJ gene before associating with an IGHD partner. Allele frequencies of structural IGH polymorphisms vary between different ethnic human populations. Differentiation of sequence variants of the IGH locus was investigated in individuals from six different ethnic backgrounds, including a rarely studied Amerindian population. Significant differentiation was observed between several pairs of populations. This work has important implications for a more personalised approach to vaccines and therapeutics. Analysis of these diverse populations suggested the existence of many novel unreported allelic variants. These alleles were then included into the repertoire used previously to study the evolution of the subregions of IGHV genes. The analysis produced remarkably similar results, suggesting that the implications for selection in these regions will not change regardless of the number of extra alleles that remain to be reported. Advisors/Committee Members: Collins, Andrew, Biotechnology & Biomolecular Sciences, Faculty of Science, UNSW.

Subjects/Keywords: antibody; immunoglobulin; heavy chain

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APA (6^th Edition):

Kidd, M. (2017). The effect of genetic variation at the immunoglobulin heavy chain variable region gene loci on biases in the generation of the human primary antibody repertoire. (Doctoral Dissertation). University of New South Wales. Retrieved from http://handle.unsw.edu.au/1959.4/58449 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:46056/SOURCE02?view=true

Chicago Manual of Style (16^th Edition):

Kidd, Marie. “The effect of genetic variation at the immunoglobulin heavy chain variable region gene loci on biases in the generation of the human primary antibody repertoire.” 2017. Doctoral Dissertation, University of New South Wales. Accessed March 01, 2021. http://handle.unsw.edu.au/1959.4/58449 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:46056/SOURCE02?view=true.

MLA Handbook (7^th Edition):

Kidd, Marie. “The effect of genetic variation at the immunoglobulin heavy chain variable region gene loci on biases in the generation of the human primary antibody repertoire.” 2017. Web. 01 Mar 2021.

Vancouver:

Kidd M. The effect of genetic variation at the immunoglobulin heavy chain variable region gene loci on biases in the generation of the human primary antibody repertoire. [Internet] [Doctoral dissertation]. University of New South Wales; 2017. [cited 2021 Mar 01]. Available from: http://handle.unsw.edu.au/1959.4/58449 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:46056/SOURCE02?view=true.

Council of Science Editors:

Kidd M. The effect of genetic variation at the immunoglobulin heavy chain variable region gene loci on biases in the generation of the human primary antibody repertoire. [Doctoral Dissertation]. University of New South Wales; 2017. Available from: http://handle.unsw.edu.au/1959.4/58449 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:46056/SOURCE02?view=true

Boston University

6. Norwood, Katherine Frances. Statistical methods & algorithms for autonomous immunoglobulin repertoire analysis.

Degree: PhD, Bioinformatics GRS, 2020, Boston University

URL: http://hdl.handle.net/2144/41875

► Investigating the immunoglobulin repertoire is a means of understanding the adaptive immune response to infectious disease or vaccine challenge. The data examined are typically generated… (more)

▼ Investigating the immunoglobulin repertoire is a means of understanding the adaptive immune response to infectious disease or vaccine challenge. The data examined are typically generated using high-throughput sequencing on samples of immunoglobulin variable-region genes present in blood or tissue collected from human or animal subjects. The analysis of these large, diverse collections provides a means of gaining insight into the specific molecular mechanisms involved in generating and maintaining a protective immune response. It involves the characterization of distinct clonal populations, specifically through the inference of founding alleles for germline gene segment recombination, as well as the lineage of accumulated mutations acquired during the development of each clone. Germline gene segment inference is currently performed by aligning immunoglobulin sequencing reads against an external reference database and assigning each read to the entry that provides the best score according to the metric used. The problem with this approach is that allelic diversity is greater than can be usefully accommodated in a static database. The absence of the alleles used from the database often leads to the misclassification of single-nucleotide polymorphisms as somatic mutations acquired during affinity maturation. This trend is especially evident with the rhesus macaque, but also affects the comparatively well-catalogued human databases, whose collections are biased towards samples from individuals of European descent. Our project presents novel statistical methods for immunoglobulin repertoire analysis which allow for the de novo inference of germline gene segment libraries directly from next-generation sequencing data, without the need for external reference databases. These methods follow a Bayesian paradigm, which uses an information-theoretic modelling approach to iteratively improve upon internal candidate gene segment libraries. Both candidate libraries and trial analyses given those libraries are incorporated as components of the machine learning evaluation procedure, allowing for the simultaneous optimization of model accuracy and simplicity. Finally, the proposed methods are evaluated using synthetic data designed to mimic known mechanisms for repertoire generation, with pre-designated parameters. We also apply these methods to known biological sources with unknown repertoire generation parameters, and conclude with a discussion on how this method can be used to identify potential novel alleles. Advisors/Committee Members: Kepler, Thomas B. (advisor).

Subjects/Keywords: Bioinformatics; Bayesian; Dirichlet; Immunoglobulin; Repertoire

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APA (6^th Edition):

Norwood, K. F. (2020). Statistical methods & algorithms for autonomous immunoglobulin repertoire analysis. (Doctoral Dissertation). Boston University. Retrieved from http://hdl.handle.net/2144/41875

Chicago Manual of Style (16^th Edition):

Norwood, Katherine Frances. “Statistical methods & algorithms for autonomous immunoglobulin repertoire analysis.” 2020. Doctoral Dissertation, Boston University. Accessed March 01, 2021. http://hdl.handle.net/2144/41875.

MLA Handbook (7^th Edition):

Norwood, Katherine Frances. “Statistical methods & algorithms for autonomous immunoglobulin repertoire analysis.” 2020. Web. 01 Mar 2021.

Vancouver:

Norwood KF. Statistical methods & algorithms for autonomous immunoglobulin repertoire analysis. [Internet] [Doctoral dissertation]. Boston University; 2020. [cited 2021 Mar 01]. Available from: http://hdl.handle.net/2144/41875.

Council of Science Editors:

Norwood KF. Statistical methods & algorithms for autonomous immunoglobulin repertoire analysis. [Doctoral Dissertation]. Boston University; 2020. Available from: http://hdl.handle.net/2144/41875

Rutgers University

7. Klartag, Ayelet. Acquired selective IgA deficiency induced by dietary bovine IgA.

Degree: MS, Cell and Developmental Biology, 2007, Rutgers University

URL: http://hdl.rutgers.edu/1782.2/rucore10001600001.ETD.16612

► Selective IgA deficiency (sIgAD) is the most common immunodeficiency in humans. Auto-reactive antibodies to human IgA are found in the serum of 20-40% of individuals… (more)

Subjects/Keywords: Immunoglobulin A

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Klartag, A. (2007). Acquired selective IgA deficiency induced by dietary bovine IgA. (Masters Thesis). Rutgers University. Retrieved from http://hdl.rutgers.edu/1782.2/rucore10001600001.ETD.16612

Chicago Manual of Style (16^th Edition):

Klartag, Ayelet. “Acquired selective IgA deficiency induced by dietary bovine IgA.” 2007. Masters Thesis, Rutgers University. Accessed March 01, 2021. http://hdl.rutgers.edu/1782.2/rucore10001600001.ETD.16612.

MLA Handbook (7^th Edition):

Klartag, Ayelet. “Acquired selective IgA deficiency induced by dietary bovine IgA.” 2007. Web. 01 Mar 2021.

Vancouver:

Klartag A. Acquired selective IgA deficiency induced by dietary bovine IgA. [Internet] [Masters thesis]. Rutgers University; 2007. [cited 2021 Mar 01]. Available from: http://hdl.rutgers.edu/1782.2/rucore10001600001.ETD.16612.

Council of Science Editors:

Klartag A. Acquired selective IgA deficiency induced by dietary bovine IgA. [Masters Thesis]. Rutgers University; 2007. Available from: http://hdl.rutgers.edu/1782.2/rucore10001600001.ETD.16612

University of KwaZulu-Natal

8. Raiman, Shenaaz. A review of the use of polyclonal intravenous immunoglobulin at a paediatric referral hospital in South Africa between 2009 and 2012.

Degree: 2014, University of KwaZulu-Natal

URL: http://hdl.handle.net/10413/14292

► Introduction Polyvalent intravenous immunoglobulin (IVIG) is registered for a limited number of specific indications in South Africa but is increasingly being used for unregistered or… (more)

▼ Introduction Polyvalent intravenous immunoglobulin (IVIG) is registered for a limited number of specific indications in South Africa but is increasingly being used for unregistered or off-label uses. No national evidence-based guidelines are available to guide clinicians with IVIG prescribing and against which use could be monitored. This results in IVIG being used in a range of clinical situations with questionable indications. Objectives and methods This study aimed to ascertain the registered and unregistered uses and cost of IVIG at a tertiary paediatric hospital in South Africa. A cross sectional descriptive study design was employed through a patient folder review, supplemented by data from the pharmacy electronic dispensing database, as well as the National Health Laboratory Service database. This study was conducted on all patients aged 0 to 18 years who were issued IVIG during a 39 month period from 2009 to 2012 within this facility. Results and discussion During the study period, 185 patients received at least one dose of IVIG and a total 916 issues (3642g) were dispensed. Use fell into the Medicines Control Council registered indications in 76 (44%) patients involving 416 (48%) issues. Only 87 (53%) of the patients were tested for HIV and in these the HIV sero-prevalence was 19%. The cost per patient amounted to ZAR15 937 in South African Rand. The highest IVIG issue-values were for Guillain-Barré syndrome (ZAR301 586), primary immunodeficiencies (ZAR340 953) and ‘other transplants’ (ZAR546 708). The annual cost for IVIG/1000 admissions adjusted for inflation was ZAR24 294, ZAR24 847and ZAR60 251 for 2009/2010, 2010/2011 and 2011/2012 financial years respectively. IVIG accounted for between 1.6%, 1.7% and 4.6% of the pharmacy expenditure per year in the study period. Conclusion More than half of all IVIG issued at this paediatric hospital was used off-label. Considering the pressures on supply and the pharmaceutical costs, manifesting as an increasing share of the pharmacy budget, a more standardised, protocol-driven approach to the prescription of IVIG is called for. It is recommended that further reviews are conducted to determine the evidence-base for the use of IVIG in the current off-label conditions. Advisors/Committee Members: Knight, Stephen Eric. (advisor), Welzel, Tyson B. (advisor).

Subjects/Keywords: Public health medicine.; Polyclonal intravenous immunoglobulin.; Intravenous immunoglobulin (IVIG)

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APA (6^th Edition):

Raiman, S. (2014). A review of the use of polyclonal intravenous immunoglobulin at a paediatric referral hospital in South Africa between 2009 and 2012. (Thesis). University of KwaZulu-Natal. Retrieved from http://hdl.handle.net/10413/14292

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Raiman, Shenaaz. “A review of the use of polyclonal intravenous immunoglobulin at a paediatric referral hospital in South Africa between 2009 and 2012.” 2014. Thesis, University of KwaZulu-Natal. Accessed March 01, 2021. http://hdl.handle.net/10413/14292.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Raiman, Shenaaz. “A review of the use of polyclonal intravenous immunoglobulin at a paediatric referral hospital in South Africa between 2009 and 2012.” 2014. Web. 01 Mar 2021.

Vancouver:

Raiman S. A review of the use of polyclonal intravenous immunoglobulin at a paediatric referral hospital in South Africa between 2009 and 2012. [Internet] [Thesis]. University of KwaZulu-Natal; 2014. [cited 2021 Mar 01]. Available from: http://hdl.handle.net/10413/14292.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Raiman S. A review of the use of polyclonal intravenous immunoglobulin at a paediatric referral hospital in South Africa between 2009 and 2012. [Thesis]. University of KwaZulu-Natal; 2014. Available from: http://hdl.handle.net/10413/14292

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Toronto

9. Ulndreaj, Antigona. Investigation of the Antibody Response and the Role of IgM Immunoglobulin in Experimental Cervical Spinal Cord Injury.

Degree: PhD, 2019, University of Toronto

URL: http://hdl.handle.net/1807/97708

► Traumatic spinal cord injury (SCI) results in motor, autonomic and sensory impairment, and is a condition for which there are no established therapies that promote… (more)

▼ Traumatic spinal cord injury (SCI) results in motor, autonomic and sensory impairment, and is a condition for which there are no established therapies that promote repair or regeneration. Antibody responses are dysregulated in traumatic SCI, leading to increased infections and autoimmunity. However, the status of antibody responses in cervical SCI (cSCI), the most common injury level seen in patients is unknown. In this thesis, I characterized the antibody responses in a clinically relevant rodent model of cSCI. There was an autoantibody response against the spinal cord in the subacute phase (2 weeks post-injury), which did not persist in the chronic phases (10 and 20 weeks post-injury) of the condition. I observed localization of IgG and IgM antibodies in the injured spinal cord, which appeared to target perilesional astrocytes and ventral horn neurons. In parallel, I found that peripheral T- and B-cell frequencies and total serum immunoglobulins were decreased 2 weeks after injury, suggesting that peripheral immune suppression and spinal cord-targeted autoreactivity co-exist in cSCI. Additionally, I found increased serum IgM immunoglobulin at 10 weeks post-injury. As IgM immunoglobulin is important in homeostasis against autoimmunity, I investigated the role of IgM immunoglobulin in IgG-mediated autoimmunity after cSCI. Mice that lacked secreted IgM were found to have impaired neurobehavioral recovery, increased lesion size and less spared white matter in their spinal cords after cCSI, as compared to wild-type controls. Moreover, IgM-deficient mice had higher complement-fixing IgG antibody deposition in the spinal cord, coupled by increased T-lymphocyte and microglia/macrophages. Taken together, these data suggest that IgM immunoglobulin serves to regulate detrimental IgG deposition during the recovery phase after SCI. In conclusion, I demonstrated that cSCI provokes an autoantibody response against the spinal cord, in conjunction with peripheral immune suppression, during the subacute phase of injury. I have also shown that IgM immunoglobulin is necessary for spontaneous recovery in cSCI, by limiting detrimental IgG deposition in the lesioned spinal cord. These novel findings advance our knowledge of the immune-mediated pathology after cSCI and warrant the further investigation of the therapeutic potential of IgM immunoglobulin during the subacute phase of SCI. Advisors/Committee Members: Fehlings, Michael G, Medical Science.

Subjects/Keywords: Autoantibodies; Autoimmunity; IgG immunoglobulin; IgM immunoglobulin; Inflammation; Spinal cord injury; 0317

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APA (6^th Edition):

Ulndreaj, A. (2019). Investigation of the Antibody Response and the Role of IgM Immunoglobulin in Experimental Cervical Spinal Cord Injury. (Doctoral Dissertation). University of Toronto. Retrieved from http://hdl.handle.net/1807/97708

Chicago Manual of Style (16^th Edition):

Ulndreaj, Antigona. “Investigation of the Antibody Response and the Role of IgM Immunoglobulin in Experimental Cervical Spinal Cord Injury.” 2019. Doctoral Dissertation, University of Toronto. Accessed March 01, 2021. http://hdl.handle.net/1807/97708.

MLA Handbook (7^th Edition):

Ulndreaj, Antigona. “Investigation of the Antibody Response and the Role of IgM Immunoglobulin in Experimental Cervical Spinal Cord Injury.” 2019. Web. 01 Mar 2021.

Vancouver:

Ulndreaj A. Investigation of the Antibody Response and the Role of IgM Immunoglobulin in Experimental Cervical Spinal Cord Injury. [Internet] [Doctoral dissertation]. University of Toronto; 2019. [cited 2021 Mar 01]. Available from: http://hdl.handle.net/1807/97708.

Council of Science Editors:

Ulndreaj A. Investigation of the Antibody Response and the Role of IgM Immunoglobulin in Experimental Cervical Spinal Cord Injury. [Doctoral Dissertation]. University of Toronto; 2019. Available from: http://hdl.handle.net/1807/97708

10. Vasquez, Brandi L. The IgA protease of pathogenic Neisseriae : transcription, targets and types.

Degree: PhD, 2002, Oregon Health Sciences University

URL: doi:10.6083/M4TX3CNS ; http://digitalcommons.ohsu.edu/etd/3222

Subjects/Keywords: Immunoglobulin A; Neisseria

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APA (6^th Edition):

Vasquez, B. L. (2002). The IgA protease of pathogenic Neisseriae : transcription, targets and types. (Doctoral Dissertation). Oregon Health Sciences University. Retrieved from doi:10.6083/M4TX3CNS ; http://digitalcommons.ohsu.edu/etd/3222

Chicago Manual of Style (16^th Edition):

Vasquez, Brandi L. “The IgA protease of pathogenic Neisseriae : transcription, targets and types.” 2002. Doctoral Dissertation, Oregon Health Sciences University. Accessed March 01, 2021. doi:10.6083/M4TX3CNS ; http://digitalcommons.ohsu.edu/etd/3222.

MLA Handbook (7^th Edition):

Vasquez, Brandi L. “The IgA protease of pathogenic Neisseriae : transcription, targets and types.” 2002. Web. 01 Mar 2021.

Vancouver:

Vasquez BL. The IgA protease of pathogenic Neisseriae : transcription, targets and types. [Internet] [Doctoral dissertation]. Oregon Health Sciences University; 2002. [cited 2021 Mar 01]. Available from: doi:10.6083/M4TX3CNS ; http://digitalcommons.ohsu.edu/etd/3222.

Council of Science Editors:

Vasquez BL. The IgA protease of pathogenic Neisseriae : transcription, targets and types. [Doctoral Dissertation]. Oregon Health Sciences University; 2002. Available from: doi:10.6083/M4TX3CNS ; http://digitalcommons.ohsu.edu/etd/3222

Universidade do Rio Grande do Sul

11. Spacil, Christiane Rodrigues. Análise da utilização de imunoglobulina humana em hospital universitário de alta complexidade do Sul do Brasil.

Degree: 2017, Universidade do Rio Grande do Sul

URL: http://hdl.handle.net/10183/170508

►

Introdução: O aumento no consumo mundial de imunoglobulina humana tem desafiado os sistemas de saúde no estabelecimento de padrões de utilização adequados a esta terapia.… (more)

▼

Introdução: O aumento no consumo mundial de imunoglobulina humana tem desafiado os sistemas de saúde no estabelecimento de padrões de utilização adequados a esta terapia. O conhecimento das políticas públicas pelos profissionais de saúde, aderidos a uma conscientização ao uso racional e estudos baseados em evidências científicas é fundamental para assegurar o acesso adequado e uma maior segurança e efetividade de tratamento. Objetivo: Avaliar a utilização de imunoglobulina humana em hospital universitário de alta complexidade do sul do país e suas indicações relacionando as mesmas aos protocolos clínicos estabelecidos. Métodos: Trata-se de um estudo transversal, retrospectivo, baseado na busca de informações através do prontuário eletrônico dos pacientes do Hospital de Clínicas de Porto Alegre no período de janeiro à dezembro de 2015 Resultados: Foram identificadas 191 prescrições de imunoglobulina humana endovenosa, totalizando 116 pacientes. Desses pacientes, 23% apresentaram síndrome de Guillain Barré, púrpura trombocitopênica idiopática, miastenia gravis, transplante renal, imunodeficiência com aumento de IgM e outras anemias hemolíticas autoimunes. Todas essas situações clínicas tem indicação de uso de acordo com os protocolos estabelecidos pelo Ministério da Saúde. Os demais casos identificados (77%) não constam nas indicações previstas nos protocolos do Ministério da Saúde. Conclusão: Foi possível identificar a utilização de imunoglobulina humana endovenosa em hospital de alta complexidade e quantificar os casos clínicos que fazem uso desse medicamento e que apresentam protocolos nacionais orientando os profissionais de saúde quanto a correta administração desse medicamento. Observou-se que a maioria dos casos identificados no estudo não apresentam regulamentos oficiais que autorizem a sua administração.

Introduction: The increase in the world consumption of human immunoglobulin has challenged the health systems in establishing appropriate standards of use for this therapy. Knowledge of public policies by health professionals adhering to rational use awareness and evidence-based studies is critical to ensure adequate access and greater safety and effectiveness of treatment. Objective: To evaluate the use of human immunoglobulin in a university hospital of high complexity in the South of the country and its indications relating them to the established clinical protocols. Methods: This is a cross-sectional, retrospective study based on the search of information through the electronic medical records of patients from the Hospital de Clínicas of Porto Alegre from January to December 2015 Results: 191 prescriptions of intravenous human immunoglobulin were identified, totaling 116 patients. Of these patients, 23% had Guillain Barré syndrome, idiopathic thrombocytopenic purpura, myasthenia gravis, renal transplantation, immunodeficiency with increased IgM and other autoimmune hemolytic anemias. All of these clinical situations are indicated for use according to protocols established by the Ministry of Health.…

Advisors/Committee Members: Bueno, Denise.

Subjects/Keywords: Immunoglobulin; Assistência farmacêutica; Imunoglobulinas; Autoimmune diseases; Safety

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APA (6^th Edition):

Spacil, C. R. (2017). Análise da utilização de imunoglobulina humana em hospital universitário de alta complexidade do Sul do Brasil. (Thesis). Universidade do Rio Grande do Sul. Retrieved from http://hdl.handle.net/10183/170508

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Spacil, Christiane Rodrigues. “Análise da utilização de imunoglobulina humana em hospital universitário de alta complexidade do Sul do Brasil.” 2017. Thesis, Universidade do Rio Grande do Sul. Accessed March 01, 2021. http://hdl.handle.net/10183/170508.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Spacil, Christiane Rodrigues. “Análise da utilização de imunoglobulina humana em hospital universitário de alta complexidade do Sul do Brasil.” 2017. Web. 01 Mar 2021.

Vancouver:

Spacil CR. Análise da utilização de imunoglobulina humana em hospital universitário de alta complexidade do Sul do Brasil. [Internet] [Thesis]. Universidade do Rio Grande do Sul; 2017. [cited 2021 Mar 01]. Available from: http://hdl.handle.net/10183/170508.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Spacil CR. Análise da utilização de imunoglobulina humana em hospital universitário de alta complexidade do Sul do Brasil. [Thesis]. Universidade do Rio Grande do Sul; 2017. Available from: http://hdl.handle.net/10183/170508

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Texas A&M University

12. Breaux, Breanna Laine. The Florida Manatee Adaptive Immune Receptor Genes Reveal Novel Patterns in Mammalian Evolution.

Degree: PhD, Veterinary Pathobiology, 2018, Texas A&M University

URL: http://hdl.handle.net/1969.1/173818

► The adaptive immune system is responsible for an antigen-specific response that is stronger and faster with each subsequent infection. The hallmarks of this response are… (more)

▼ The adaptive immune system is responsible for an antigen-specific response that is stronger and faster with each subsequent infection. The hallmarks of this response are the B cell and the T cell, which are responsible for recognizing foreign antigens through their highly diverse receptors: the immunoglobulin (Ig) and T cell receptor (TR). These receptors have been studied in many mammalian species, however there are still gaps in our knowledge throughout mammalian evolution. Two eutherian sister superorders, Afrotheria and Xenarthra, have been neglected in this field of research. Therefore, we chose to characterize the adaptive immune receptor genes of the Florida manatee (Trichechus manatus latirostris), the only afrotherian species that inhabits the United States. We annotated the adaptive immune receptor loci in the genomic scaffolds of the Florida manatee genome and sequenced expressed transcripts using PacBio SMRT sequencing. In the IgH locus, we found limited IgHV diversity. The IgHV segments were limited in number and sequence diversity; the Florida manatee lacked clan III IgHV segments, which are conserved throughout most mammals. The loss of clan III IgHV consistently correlated to a decrease in the number of functional IgHV in cattle, sheep, and horse. This shared phenomenon in an evolutionarily distinct species highlighted the role of the clan III IgHV segments in maintaining locus diversity. Overall, the three TR loci had average to above average diversity. We separated the Florida manatee TRV segments into subgroups based on 75% nucleotide identity and identified conserved subgroups and subgroup order compared to the human TR loci. We identified a direct correlation between locus complexity, TRV sequence conservation, and locus synteny. This revealed the magnitude of overall maintenance of each TR locus across two divergent eutherian mammals for the first time. It also emphasized the role of locus organization on gene evolution. By including this understudied eutherian superorder into the analysis of these complex genes, we identified new evolutionary patterns that help us understand the factors that shaped our immune response. Advisors/Committee Members: Criscitiello, Michael F (advisor), Berghman, Luc R (committee member), Tizard, Ian R (committee member), Hurtado, Luis A (committee member).

Subjects/Keywords: immunoglobulin; t cell receptor; manatee; clan; synteny

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Breaux, B. L. (2018). The Florida Manatee Adaptive Immune Receptor Genes Reveal Novel Patterns in Mammalian Evolution. (Doctoral Dissertation). Texas A&M University. Retrieved from http://hdl.handle.net/1969.1/173818

Chicago Manual of Style (16^th Edition):

Breaux, Breanna Laine. “The Florida Manatee Adaptive Immune Receptor Genes Reveal Novel Patterns in Mammalian Evolution.” 2018. Doctoral Dissertation, Texas A&M University. Accessed March 01, 2021. http://hdl.handle.net/1969.1/173818.

MLA Handbook (7^th Edition):

Breaux, Breanna Laine. “The Florida Manatee Adaptive Immune Receptor Genes Reveal Novel Patterns in Mammalian Evolution.” 2018. Web. 01 Mar 2021.

Vancouver:

Breaux BL. The Florida Manatee Adaptive Immune Receptor Genes Reveal Novel Patterns in Mammalian Evolution. [Internet] [Doctoral dissertation]. Texas A&M University; 2018. [cited 2021 Mar 01]. Available from: http://hdl.handle.net/1969.1/173818.

Council of Science Editors:

Breaux BL. The Florida Manatee Adaptive Immune Receptor Genes Reveal Novel Patterns in Mammalian Evolution. [Doctoral Dissertation]. Texas A&M University; 2018. Available from: http://hdl.handle.net/1969.1/173818

Texas A&M University

13. Breaux, Breanna Laine. The Florida Manatee Adaptive Immune Receptor Genes Reveal Novel Patterns in Mammalian Evolution.

Degree: PhD, Veterinary Pathobiology, 2018, Texas A&M University

URL: http://hdl.handle.net/1969.1/173723

► The adaptive immune system is responsible for an antigen-specific response that is stronger and faster with each subsequent infection. The hallmarks of this response are… (more)

▼ The adaptive immune system is responsible for an antigen-specific response that is stronger and faster with each subsequent infection. The hallmarks of this response are the B cell and the T cell, which are responsible for recognizing foreign antigens through their highly diverse receptors: the immunoglobulin (Ig) and T cell receptor (TR). These receptors have been studied in many mammalian species, however there are still gaps in our knowledge throughout mammalian evolution. Two eutherian sister superorders, Afrotheria and Xenarthra, have been neglected in this field of research. Therefore, we chose to characterize the adaptive immune receptor genes of the Florida manatee (Trichechus manatus latirostris), the only afrotherian species that inhabits the United States. We annotated the adaptive immune receptor loci in the genomic scaffolds of the Florida manatee genome and sequenced expressed transcripts using PacBio SMRT sequencing. In the IgH locus, we found limited IgHV diversity. The IgHV segments were limited in number and sequence diversity; the Florida manatee lacked clan III IgHV segments, which are conserved throughout most mammals. The loss of clan III IgHV consistently correlated to a decrease in the number of functional IgHV in cattle, sheep, and horse. This shared phenomenon in an evolutionarily distinct species highlighted the role of the clan III IgHV segments in maintaining locus diversity. Overall, the three TR loci had average to above average diversity. We separated the Florida manatee TRV segments into subgroups based on 75% nucleotide identity and identified conserved subgroups and subgroup order compared to the human TR loci. We identified a direct correlation between locus complexity, TRV sequence conservation, and locus synteny. This revealed the magnitude of overall maintenance of each TR locus across two divergent eutherian mammals for the first time. It also emphasized the role of locus organization on gene evolution. By including this understudied eutherian superorder into the analysis of these complex genes, we identified new evolutionary patterns that help us understand the factors that shaped our immune response. Advisors/Committee Members: Criscitiello, Michael F (advisor), Berghman, Luc R (committee member), Tizard, Ian R (committee member), Hurtado, Luis A (committee member).

Subjects/Keywords: immunoglobulin; t cell receptor; manatee; clan; synteny

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❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Breaux, B. L. (2018). The Florida Manatee Adaptive Immune Receptor Genes Reveal Novel Patterns in Mammalian Evolution. (Doctoral Dissertation). Texas A&M University. Retrieved from http://hdl.handle.net/1969.1/173723

Chicago Manual of Style (16^th Edition):

Breaux, Breanna Laine. “The Florida Manatee Adaptive Immune Receptor Genes Reveal Novel Patterns in Mammalian Evolution.” 2018. Doctoral Dissertation, Texas A&M University. Accessed March 01, 2021. http://hdl.handle.net/1969.1/173723.

MLA Handbook (7^th Edition):

Breaux, Breanna Laine. “The Florida Manatee Adaptive Immune Receptor Genes Reveal Novel Patterns in Mammalian Evolution.” 2018. Web. 01 Mar 2021.

Vancouver:

Breaux BL. The Florida Manatee Adaptive Immune Receptor Genes Reveal Novel Patterns in Mammalian Evolution. [Internet] [Doctoral dissertation]. Texas A&M University; 2018. [cited 2021 Mar 01]. Available from: http://hdl.handle.net/1969.1/173723.

Council of Science Editors:

Breaux BL. The Florida Manatee Adaptive Immune Receptor Genes Reveal Novel Patterns in Mammalian Evolution. [Doctoral Dissertation]. Texas A&M University; 2018. Available from: http://hdl.handle.net/1969.1/173723

Texas A&M University

14. Mashoof, Sara. Evolution of Mucosal Immunoglobulins: Xenopus Laevis IgX and Thunnus Orientalis IgZ/T.

Degree: PhD, Veterinary Microbiology, 2014, Texas A&M University

URL: http://hdl.handle.net/1969.1/152474

► Despite a large number of studies during the last decade that investigated mucosal immunity in humans, very few works have been done on this immune… (more)

▼ Despite a large number of studies during the last decade that investigated mucosal immunity in humans, very few works have been done on this immune compartment in lower vertebrates. In the following two studies we focused on the mucosal immunoglobulins in two important species of two classes of ectothermic vertebrates: amphibians and bony fishes. Many studies address the influence of the gut microbiome on the immune system, but few dissect the effect of T cells on gut microbiota and mucosal responses. We have employed larval thymectomy in Xenopus to study the gut microbiota with and without the influence of T lymphocytes. Pyrosequencing of 16S ribosomal RNA genes was used to assess the relative abundance of bacterial groups present in the stomach, and the small and large intestine. Clostridiaceae were the most abundant family throughout the gut, while Bacteroidaceae, Enterobacteriaceae, and Flavobacteriaceae also were well represented. Unifrac analysis revealed no differences in microbiota distribution between thymectomized and unoperated frogs. This is consistent with immunization data showing that levels of the mucosal immunoglobulin IgX are not altered significantly by thymectomy. This study in Xenopus represents the oldest organisms that exhibit class switch to a mucosal isotype and is relevant to mammalian immunology, as IgA appears to have evolved from IgX based upon phylogeny, genomic synteny, and function. It is now appreciated that in addition to the immunoglobulin (Ig)M and D isotypes fish also make the mucosal IgT. In this study we sequenced the full length of Ig tau as well as mu in the commercially important Thunnus orientalis (Pacific bluefin tuna), the first analysis of both of these Ig isotypes in a member of the order Perciformes. Tuna IgM and IgT are each composed of four constant (CH) domains. We cloned and sequenced 48 different variable (VH) domain rearrangements of tuna immunoglobulins and grouped the VH gene sequences to four VH gene segment families based on 70% nucleotide identity. Three VH gene families were used by both IgM and IgT but one group was only found to be used by IgM. Most interestingly, both Ig mu and Ig tau clones appear to use the same diversity (DH) segment, unlike what has been described in other species, although they have dedicated IgT and IgM joining (JH) gene segments. We complemented this repertoire study with phylogenetic and tissue expression analysis. In addition to supporting the development of humoral vaccines in this important aquaculture species, these data suggest that the DH-JH recombination rather than the VH-DH recombination may be instructive for IgT versus IgM/D bearing lymphocyte lineages in some fish. Advisors/Committee Members: Criscitiello, Michael (advisor), Tizard, Ian (committee member), Berghman, Luc (committee member), Rivera, Gonzalo (committee member).

Subjects/Keywords: Xenopus Laevis; Immunoglobulin; Tuna; Mucosal Immunity; IgT

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Mashoof, S. (2014). Evolution of Mucosal Immunoglobulins: Xenopus Laevis IgX and Thunnus Orientalis IgZ/T. (Doctoral Dissertation). Texas A&M University. Retrieved from http://hdl.handle.net/1969.1/152474

Chicago Manual of Style (16^th Edition):

Mashoof, Sara. “Evolution of Mucosal Immunoglobulins: Xenopus Laevis IgX and Thunnus Orientalis IgZ/T.” 2014. Doctoral Dissertation, Texas A&M University. Accessed March 01, 2021. http://hdl.handle.net/1969.1/152474.

MLA Handbook (7^th Edition):

Mashoof, Sara. “Evolution of Mucosal Immunoglobulins: Xenopus Laevis IgX and Thunnus Orientalis IgZ/T.” 2014. Web. 01 Mar 2021.

Vancouver:

Mashoof S. Evolution of Mucosal Immunoglobulins: Xenopus Laevis IgX and Thunnus Orientalis IgZ/T. [Internet] [Doctoral dissertation]. Texas A&M University; 2014. [cited 2021 Mar 01]. Available from: http://hdl.handle.net/1969.1/152474.

Council of Science Editors:

Mashoof S. Evolution of Mucosal Immunoglobulins: Xenopus Laevis IgX and Thunnus Orientalis IgZ/T. [Doctoral Dissertation]. Texas A&M University; 2014. Available from: http://hdl.handle.net/1969.1/152474

Penn State University

15. Lopez Cabus, Alberto. A comparison of IgG absorption and concentration levels in calves fed a commercial colostrum replacer or supplemented maternal colostrum.

Degree: 2019, Penn State University

URL: https://submit-etda.libraries.psu.edu/catalog/17235ajl94

► Experiments were conducted to determine if calves fed an available commercial colostrum replacer could provide similar IgG concentrations absorptions values, growth parameters and health scores… (more)

▼ Experiments were conducted to determine if calves fed an available commercial colostrum replacer could provide similar IgG concentrations absorptions values, growth parameters and health scores compared to maternal colostrum. Successful passive transfer of antibodies in neonatal calves can be achieved by feeding maternal colostrum (MC) or colostrum replacer (CR). An alternative strategy could be a supplemented low-quality maternal colostrum (CS). The objective of this study was to determine if a commercial colostrum product (Premolac PLUS Bovine IgG, Zinpro Corporation, Eden Prairie, MN) fed to replace or supplement MC could lead to adequate IgG levels and apparent efficiency of absorption (AEA) 24 h after birth in neonatal dairy calves. Furthermore, growth parameters and health score data was also evaluated. Holstein calves (n=20/treatment) were separated from their dam after birth and randomly assigned to 1 of 2 levels of CR (110 g or 150 g of IgG fed), low-quality colostrum (30 g IgG/L) supplemented with CR (154 g IgG total fed; 41 g/L IgG fed) or MC (106 g IgG/L; 401 g IgG fed; positive control) within 1.5 h of birth. Colostrum was obtained from first (MC) or second and third milking (CS) of cows from The Pennsylvania State University dairy. Then, it was pooled in two batches and analyzed for total IgG concentration using radial immunodiffusion. Blood samples were taken from calves before feeding one of the four colostrum treatments and 24 h after birth. Samples were analyzed for serum total protein, total IgG, hematocrit, and Brix. The same procedure was followed to take weekly blood samples until week 7 in order to analyze the IgG behavior. A total of 80 calves were used for BW and structural growth evaluation. Calves were housed in 1.2 × 1.4 m individual pens from birth until wk 7 of age. Weekly measurements were taken including body weight, withers height and hip width. Also, health scores were observed and recorded every day for the length of the trial. All calves were fed 6 L of pasteurized whole milk in 2 feedings (AM-PM). Pasteurization was done using a batch pasteurizer (PLV model, 2c Duecinox, Guastalla, Italy) which heated the milk at 65ºC (149ºF) for 30 min. Calves were weaned at the age of 7 weeks. Reported means are followed by their standard errors. MC had higher 24 h IgG values than CS (27.04 ± 1.07 and 22.33 ± 1.08 mg/mL, respectively; P<0.01). Feeding 150 g of IgG in CR led to higher 24 h serum IgG values than feeding 110 g of IgG (16.90 ± 1.09 and 12.79 ± 1.08 mg/mL, respectively; P<0.01). Serum IgG levels at 24 h were statistically different between CR-110 and CR-150 against CS and MC (12.79, 16.90, 22.33, and 27.04 mg/mL, respectively; P<0.01), but all had average values above 10 mg/mL IgG. Calves fed CS had greater AEA than calves fed MC (54.58 ± 2.39 and 24.38 ± 2.36%, respectively; P<0.01). Among calves fed CR with 110 g or 150 g of IgG, AEA wasn’t different (P=0.68). Total protein and Brix had a strong correlation (r=0.98, P=<0.01). Weekly IgG concentration values demonstrated a similar… Advisors/Committee Members: Arlyn Judson Heinrichs, Thesis Advisor/Co-Advisor, Lisa Holden, Committee Member, Chad Daniel Dechow, Committee Member, Terry D Etherton, Program Head/Chair.

Subjects/Keywords: Calf; Immunoglobulin G; Colostrum; Colostrum replacer

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Lopez Cabus, A. (2019). A comparison of IgG absorption and concentration levels in calves fed a commercial colostrum replacer or supplemented maternal colostrum. (Thesis). Penn State University. Retrieved from https://submit-etda.libraries.psu.edu/catalog/17235ajl94

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Lopez Cabus, Alberto. “A comparison of IgG absorption and concentration levels in calves fed a commercial colostrum replacer or supplemented maternal colostrum.” 2019. Thesis, Penn State University. Accessed March 01, 2021. https://submit-etda.libraries.psu.edu/catalog/17235ajl94.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Lopez Cabus, Alberto. “A comparison of IgG absorption and concentration levels in calves fed a commercial colostrum replacer or supplemented maternal colostrum.” 2019. Web. 01 Mar 2021.

Vancouver:

Lopez Cabus A. A comparison of IgG absorption and concentration levels in calves fed a commercial colostrum replacer or supplemented maternal colostrum. [Internet] [Thesis]. Penn State University; 2019. [cited 2021 Mar 01]. Available from: https://submit-etda.libraries.psu.edu/catalog/17235ajl94.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Lopez Cabus A. A comparison of IgG absorption and concentration levels in calves fed a commercial colostrum replacer or supplemented maternal colostrum. [Thesis]. Penn State University; 2019. Available from: https://submit-etda.libraries.psu.edu/catalog/17235ajl94

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Penn State University

16. James, Jamaal L. The regulation of immunoglobulin E responses requires the vitamin D receptor.

Degree: 2016, Penn State University

URL: https://submit-etda.libraries.psu.edu/catalog/28934

► Immunoglobulin (E) levels are normally kept low in circulation. Several environmental factors play roles in maintaining low IgE levels. Vitamin D deficiency has been linked… (more)

▼ Immunoglobulin (E) levels are normally kept low in circulation. Several environmental factors play roles in maintaining low IgE levels. Vitamin D deficiency has been linked to high IgE levels and allergic asthma incidence. Allergic asthma is a disease of the lung characterized by strong Th2 driven airway inflammation and airway obstruction. The immune system uses several mechanisms to limit inappropriate IgE responses. The vitamin D receptor (VDR) is expressed in all immune cells. VDR knockout (KO) mice have abnormally high circulating IgE levels. Th2 cytokine IL-4 controls B cell class switching to IgE. Uncontrolled IgE responses often occur after B cells have encountered excess T cell-derived IL-4 in result of IL-4 overproduction or cytokine imbalances. The intestinal microenvironment harbors host immune cells that interact with commensal microbes to limit IgE levels and promote immune unresponsiveness to environmental antigens. Other than being regulated by microbial signals, IgE production by B cells is not only self-restricted, but also limited by cytokines in an autocrine manner or from other immune cells. In this work, we hypothesize that vitamin D regulates IgE levels through B cell intrinsic and extrinsic mechanisms that involve IL-10 and tolerogenic CD103+ dendritic cells (DC), but not commensal microbes. The first objective of this research was to determine the major vitamin D targets during the IgE response to T-dependent antigens. The second was to determine whether a cytokine imbalance occurs in VDR KO mice immunized with OVA in Alum. Finally we determined whether there is a link between vitamin D and the microbiome in regulating IgE levels. The work presented here reveals a role for vitamin D in maintaining low IgE levels by regulating B cells. The VDR is required for B cells to self regulate as they mount IgE responses to T dependent antigens. Fewer IL-10-producing B (B10) cells respond to OVA during immunization. VDR KO B cells overproduce IgE and fail to produce IL-10 in a context dependent manner. VDR KO B10 cells have altered phenotypes suggesting functional defects in immunoregulation. IL-10 mitigates the effects of VDR deficiency on the IgE response, indicating a modulatory role for IL-10 in IgE production. Fewer tolerogenic CD103+ DCs are associated with hyper-IgE in VDR KO mice. Commensal microbes do not contribute to hyper-IgE in VDR KO mice. In healthy mice, vitamin D regulates B cells to maintain low IgE levels in a mechanism that possibly involves regulatory B10 cells. Advisors/Committee Members: Margherita Teresa Anna Cantorna, Dissertation Advisor/Co-Advisor, Margherita Teresa Anna Cantorna, Committee Chair/Co-Chair, Kumble Sandeep Prabhu, Committee Member, Andrea Marie Mastro, Committee Member, Connie Jo Rogers, Special Member.

Subjects/Keywords: Immunology; Vitamin D; Allergic asthma; Immunoglobulin E

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APA (6^th Edition):

James, J. L. (2016). The regulation of immunoglobulin E responses requires the vitamin D receptor. (Thesis). Penn State University. Retrieved from https://submit-etda.libraries.psu.edu/catalog/28934

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

James, Jamaal L. “The regulation of immunoglobulin E responses requires the vitamin D receptor.” 2016. Thesis, Penn State University. Accessed March 01, 2021. https://submit-etda.libraries.psu.edu/catalog/28934.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

James, Jamaal L. “The regulation of immunoglobulin E responses requires the vitamin D receptor.” 2016. Web. 01 Mar 2021.

Vancouver:

James JL. The regulation of immunoglobulin E responses requires the vitamin D receptor. [Internet] [Thesis]. Penn State University; 2016. [cited 2021 Mar 01]. Available from: https://submit-etda.libraries.psu.edu/catalog/28934.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

James JL. The regulation of immunoglobulin E responses requires the vitamin D receptor. [Thesis]. Penn State University; 2016. Available from: https://submit-etda.libraries.psu.edu/catalog/28934

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Adelaide

17. Souter, Warwick. Macroglobulins in normal pig serum.

Degree: 1973, University of Adelaide

URL: http://hdl.handle.net/2440/116685

Subjects/Keywords: Macroglobulins; Immunoglobulin M

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APA (6^th Edition):

Souter, W. (1973). Macroglobulins in normal pig serum. (Thesis). University of Adelaide. Retrieved from http://hdl.handle.net/2440/116685

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Souter, Warwick. “Macroglobulins in normal pig serum.” 1973. Thesis, University of Adelaide. Accessed March 01, 2021. http://hdl.handle.net/2440/116685.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Souter, Warwick. “Macroglobulins in normal pig serum.” 1973. Web. 01 Mar 2021.

Vancouver:

Souter W. Macroglobulins in normal pig serum. [Internet] [Thesis]. University of Adelaide; 1973. [cited 2021 Mar 01]. Available from: http://hdl.handle.net/2440/116685.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Souter W. Macroglobulins in normal pig serum. [Thesis]. University of Adelaide; 1973. Available from: http://hdl.handle.net/2440/116685

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Adelaide

18. Udomsantisuk, Pakathip S. IgA levels after oral vaccination of mice with Salmonella.

Degree: 1983, University of Adelaide

URL: http://hdl.handle.net/2440/110514

Subjects/Keywords: Immunoglobulin A; Salmonellosis

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APA (6^th Edition):

Udomsantisuk, P. S. (1983). IgA levels after oral vaccination of mice with Salmonella. (Thesis). University of Adelaide. Retrieved from http://hdl.handle.net/2440/110514

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Udomsantisuk, Pakathip S. “IgA levels after oral vaccination of mice with Salmonella.” 1983. Thesis, University of Adelaide. Accessed March 01, 2021. http://hdl.handle.net/2440/110514.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Udomsantisuk, Pakathip S. “IgA levels after oral vaccination of mice with Salmonella.” 1983. Web. 01 Mar 2021.

Vancouver:

Udomsantisuk PS. IgA levels after oral vaccination of mice with Salmonella. [Internet] [Thesis]. University of Adelaide; 1983. [cited 2021 Mar 01]. Available from: http://hdl.handle.net/2440/110514.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Udomsantisuk PS. IgA levels after oral vaccination of mice with Salmonella. [Thesis]. University of Adelaide; 1983. Available from: http://hdl.handle.net/2440/110514

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Columbia University

19. Kazadi, David. RNA:DNA Heteroduplex Resolution in B-Lymphocyte Immunoglobulin Diversification and Genomic Maintenance.

Degree: 2016, Columbia University

URL: https://doi.org/10.7916/D8319VWQ

► Immunoglobulin (Ig) gene diversification plays an essential role in adaptive immunity. Faced with a continuous yet varied stream of self, non-self, and possibly harmful molecules,… (more)

▼ Immunoglobulin (Ig) gene diversification plays an essential role in adaptive immunity. Faced with a continuous yet varied stream of self, non-self, and possibly harmful molecules, many organisms have mechanisms in their arsenal that have evolved to match the diversity of the antigens they encounter. In humans and mice, developing B and T lymphocytes go through a first round of genomic alteration — V(D)J recombination — in the bone marrow and the thymus, respectively. B cells can subsequently undergo two additional Ig gene diversification processes in secondary lymphoid tissues. Through somatic hypermutation (SHM), Ig variable regions of stimulated germinal center (GC)-forming B cells are mutated and further diversified, enabling affinity maturation. During class-switch recombination (CSR), on the other hand, B cells in the GC or prior to entering the GC recombine Ig constant regions, swapping the IgM-encoding locus for another isotype constant regions gene (e.g., IgG1, IgG3, IgE, IgA) to allow for different effector functions. Both B cell-specific genomic alterations are initiated when the single-stranded DNA (ssDNA) mutator enzyme activation-induced cytidine deaminase (AID) catalyzes the removal of the amino group off deoxycytidine residues, resulting in deoxyuridines and dU:dG mismatches. Low-fidelity cellular responses to the presence of dU, including the mismatch repair (MMR) and the base-excision repair (BER) pathways, are then thought to introduce mutations in SHM and CSR, as well as cause double-strand breaks (DSBs) repaired through canonical and alternative non-homologous end-joining in CSR. Though necessary for proper physiological function, these lymphocyte genome diversification processes are rife with danger for B cells and there is strong selective pressure to carefully orchestrate and target them so as not to threaten the genomic integrity of the cells through breaks or other mutations at non-Ig loci. Yet, these events can still occur, as demonstrated by the implication of AID with translocations found in some cancers (e.g., c- MYC:IGH in Burkitt’s lymphoma). Therefore, the mechanisms underlying AID mutagenic activity targeting to physiological deamination substrates have been the focus of several studies. Protein kinase A (PKA)-dependent phosphorylation of AID at its serine 38 residue has been shown to enable its interaction with replication protein A (RPA) before binding to ssDNA. Others have reported that SPT5 helps target AID to sites of RNA polymerase II (Pol II) stalling, such as the Ig switch sequences. Another cofactor, the RNA exosome complex, helps target the ssDNA mutator AID to both strands of DNA in vivo. The RNA exosome had hitherto been described in the context of RNA processing and degradation as 3’ → 5’ exoribonuclease. Sterile transcript-generating transcription at Ig loci was known to be required for proper AID catalytic activity; the newly described link between the RNA exosome and AID activity raised the prospect that RNA processing, and not mere transcription, might be…

Subjects/Keywords: Immunoglobulin genes; Antibody diversity; B cells; Immunology

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APA (6^th Edition):

Kazadi, D. (2016). RNA:DNA Heteroduplex Resolution in B-Lymphocyte Immunoglobulin Diversification and Genomic Maintenance. (Doctoral Dissertation). Columbia University. Retrieved from https://doi.org/10.7916/D8319VWQ

Chicago Manual of Style (16^th Edition):

Kazadi, David. “RNA:DNA Heteroduplex Resolution in B-Lymphocyte Immunoglobulin Diversification and Genomic Maintenance.” 2016. Doctoral Dissertation, Columbia University. Accessed March 01, 2021. https://doi.org/10.7916/D8319VWQ.

MLA Handbook (7^th Edition):

Kazadi, David. “RNA:DNA Heteroduplex Resolution in B-Lymphocyte Immunoglobulin Diversification and Genomic Maintenance.” 2016. Web. 01 Mar 2021.

Vancouver:

Kazadi D. RNA:DNA Heteroduplex Resolution in B-Lymphocyte Immunoglobulin Diversification and Genomic Maintenance. [Internet] [Doctoral dissertation]. Columbia University; 2016. [cited 2021 Mar 01]. Available from: https://doi.org/10.7916/D8319VWQ.

Council of Science Editors:

Kazadi D. RNA:DNA Heteroduplex Resolution in B-Lymphocyte Immunoglobulin Diversification and Genomic Maintenance. [Doctoral Dissertation]. Columbia University; 2016. Available from: https://doi.org/10.7916/D8319VWQ

20. Mink, J.G. Serum immunoglobulin levels and immunoglobulin heterogeneity in the mouse.

Degree: 1980, Erasmus University Medical Center

URL: http://hdl.handle.net/1765/31501

► textabstractThe experiments described in this thesis were performed in attempts to obtain quantitative and qualitative data on the overall activity of the humoral immune system… (more)

Subjects/Keywords: immunoglobulin; mice; thymus

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APA (6^th Edition):

Mink, J. G. (1980). Serum immunoglobulin levels and immunoglobulin heterogeneity in the mouse. (Doctoral Dissertation). Erasmus University Medical Center. Retrieved from http://hdl.handle.net/1765/31501

Chicago Manual of Style (16^th Edition):

Mink, J G. “Serum immunoglobulin levels and immunoglobulin heterogeneity in the mouse.” 1980. Doctoral Dissertation, Erasmus University Medical Center. Accessed March 01, 2021. http://hdl.handle.net/1765/31501.

MLA Handbook (7^th Edition):

Mink, J G. “Serum immunoglobulin levels and immunoglobulin heterogeneity in the mouse.” 1980. Web. 01 Mar 2021.

Vancouver:

Mink JG. Serum immunoglobulin levels and immunoglobulin heterogeneity in the mouse. [Internet] [Doctoral dissertation]. Erasmus University Medical Center; 1980. [cited 2021 Mar 01]. Available from: http://hdl.handle.net/1765/31501.

Council of Science Editors:

Mink JG. Serum immunoglobulin levels and immunoglobulin heterogeneity in the mouse. [Doctoral Dissertation]. Erasmus University Medical Center; 1980. Available from: http://hdl.handle.net/1765/31501

University of Melbourne

21. Martínez-López, Lina María. The role of the intestinal microbiota in the pathogenesis of chronic enteropathies and their interplay with the immune system.

Degree: 2018, University of Melbourne

URL: http://hdl.handle.net/11343/216242

► The intestinal microbiota and its associated genome is collectively called the gastrointestinal (GI) microbiome, and is composed of crucial components that help not only to… (more)

Subjects/Keywords: canine chronic enteropathy; immunoglobulin; TSLP; gut microbiota

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APA (6^th Edition):

Martínez-López, L. M. (2018). The role of the intestinal microbiota in the pathogenesis of chronic enteropathies and their interplay with the immune system. (Doctoral Dissertation). University of Melbourne. Retrieved from http://hdl.handle.net/11343/216242

Chicago Manual of Style (16^th Edition):

Martínez-López, Lina María. “The role of the intestinal microbiota in the pathogenesis of chronic enteropathies and their interplay with the immune system.” 2018. Doctoral Dissertation, University of Melbourne. Accessed March 01, 2021. http://hdl.handle.net/11343/216242.

MLA Handbook (7^th Edition):

Martínez-López, Lina María. “The role of the intestinal microbiota in the pathogenesis of chronic enteropathies and their interplay with the immune system.” 2018. Web. 01 Mar 2021.

Vancouver:

Martínez-López LM. The role of the intestinal microbiota in the pathogenesis of chronic enteropathies and their interplay with the immune system. [Internet] [Doctoral dissertation]. University of Melbourne; 2018. [cited 2021 Mar 01]. Available from: http://hdl.handle.net/11343/216242.

Council of Science Editors:

Martínez-López LM. The role of the intestinal microbiota in the pathogenesis of chronic enteropathies and their interplay with the immune system. [Doctoral Dissertation]. University of Melbourne; 2018. Available from: http://hdl.handle.net/11343/216242

University of Arizona

22. Lohman, Isabelle Carlotta, 1948-. THE PRODUCTION AND PURIFICATION OF RABBIT SERUM IMMUNOGLOBULIN-E, AND THE ROLE OF IMMUNOGLOBULIN-E IN SYSTEMIC ANAPHYLAXIS .

Degree: 1987, University of Arizona

URL: http://hdl.handle.net/10150/291183

Subjects/Keywords: Immunoglobulin E.; Anaphylaxis.

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APA (6^th Edition):

Lohman, Isabelle Carlotta, 1. (1987). THE PRODUCTION AND PURIFICATION OF RABBIT SERUM IMMUNOGLOBULIN-E, AND THE ROLE OF IMMUNOGLOBULIN-E IN SYSTEMIC ANAPHYLAXIS . (Masters Thesis). University of Arizona. Retrieved from http://hdl.handle.net/10150/291183

Chicago Manual of Style (16^th Edition):

Lohman, Isabelle Carlotta, 1948-. “THE PRODUCTION AND PURIFICATION OF RABBIT SERUM IMMUNOGLOBULIN-E, AND THE ROLE OF IMMUNOGLOBULIN-E IN SYSTEMIC ANAPHYLAXIS .” 1987. Masters Thesis, University of Arizona. Accessed March 01, 2021. http://hdl.handle.net/10150/291183.

MLA Handbook (7^th Edition):

Lohman, Isabelle Carlotta, 1948-. “THE PRODUCTION AND PURIFICATION OF RABBIT SERUM IMMUNOGLOBULIN-E, AND THE ROLE OF IMMUNOGLOBULIN-E IN SYSTEMIC ANAPHYLAXIS .” 1987. Web. 01 Mar 2021.

Vancouver:

Lohman, Isabelle Carlotta 1. THE PRODUCTION AND PURIFICATION OF RABBIT SERUM IMMUNOGLOBULIN-E, AND THE ROLE OF IMMUNOGLOBULIN-E IN SYSTEMIC ANAPHYLAXIS . [Internet] [Masters thesis]. University of Arizona; 1987. [cited 2021 Mar 01]. Available from: http://hdl.handle.net/10150/291183.

Council of Science Editors:

Lohman, Isabelle Carlotta 1. THE PRODUCTION AND PURIFICATION OF RABBIT SERUM IMMUNOGLOBULIN-E, AND THE ROLE OF IMMUNOGLOBULIN-E IN SYSTEMIC ANAPHYLAXIS . [Masters Thesis]. University of Arizona; 1987. Available from: http://hdl.handle.net/10150/291183

University of Hong Kong

23. Tang, Cheuk-on. A study of clonality of lymphoma of SJL mice using immunoglobulin generearrangements and murine leukaemia virus integration.

Degree: 1996, University of Hong Kong

URL: http://hdl.handle.net/10722/39380

Subjects/Keywords: Lymphomas.; Immunoglobulin genes.

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APA (6^th Edition):

Tang, C. (1996). A study of clonality of lymphoma of SJL mice using immunoglobulin generearrangements and murine leukaemia virus integration. (Thesis). University of Hong Kong. Retrieved from http://hdl.handle.net/10722/39380

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Tang, Cheuk-on. “A study of clonality of lymphoma of SJL mice using immunoglobulin generearrangements and murine leukaemia virus integration.” 1996. Thesis, University of Hong Kong. Accessed March 01, 2021. http://hdl.handle.net/10722/39380.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Tang, Cheuk-on. “A study of clonality of lymphoma of SJL mice using immunoglobulin generearrangements and murine leukaemia virus integration.” 1996. Web. 01 Mar 2021.

Vancouver:

Tang C. A study of clonality of lymphoma of SJL mice using immunoglobulin generearrangements and murine leukaemia virus integration. [Internet] [Thesis]. University of Hong Kong; 1996. [cited 2021 Mar 01]. Available from: http://hdl.handle.net/10722/39380.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Tang C. A study of clonality of lymphoma of SJL mice using immunoglobulin generearrangements and murine leukaemia virus integration. [Thesis]. University of Hong Kong; 1996. Available from: http://hdl.handle.net/10722/39380

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Arizona

24. Halonen, Marilyn Jean, 1941-. RABBIT IMMUNOGLOBULIN-E ANTIBODY: ONTOGENY OF ITS SYNTHESIS AND ITS ROLE IN SYSTEMIC ANAPHYLAXIS .

Degree: 1974, University of Arizona

URL: http://hdl.handle.net/10150/290363

Subjects/Keywords: Anaphylaxis.; Immunoglobulin E.

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APA (6^th Edition):

Halonen, Marilyn Jean, 1. (1974). RABBIT IMMUNOGLOBULIN-E ANTIBODY: ONTOGENY OF ITS SYNTHESIS AND ITS ROLE IN SYSTEMIC ANAPHYLAXIS . (Doctoral Dissertation). University of Arizona. Retrieved from http://hdl.handle.net/10150/290363

Chicago Manual of Style (16^th Edition):

Halonen, Marilyn Jean, 1941-. “RABBIT IMMUNOGLOBULIN-E ANTIBODY: ONTOGENY OF ITS SYNTHESIS AND ITS ROLE IN SYSTEMIC ANAPHYLAXIS .” 1974. Doctoral Dissertation, University of Arizona. Accessed March 01, 2021. http://hdl.handle.net/10150/290363.

MLA Handbook (7^th Edition):

Halonen, Marilyn Jean, 1941-. “RABBIT IMMUNOGLOBULIN-E ANTIBODY: ONTOGENY OF ITS SYNTHESIS AND ITS ROLE IN SYSTEMIC ANAPHYLAXIS .” 1974. Web. 01 Mar 2021.

Vancouver:

Halonen, Marilyn Jean 1. RABBIT IMMUNOGLOBULIN-E ANTIBODY: ONTOGENY OF ITS SYNTHESIS AND ITS ROLE IN SYSTEMIC ANAPHYLAXIS . [Internet] [Doctoral dissertation]. University of Arizona; 1974. [cited 2021 Mar 01]. Available from: http://hdl.handle.net/10150/290363.

Council of Science Editors:

Halonen, Marilyn Jean 1. RABBIT IMMUNOGLOBULIN-E ANTIBODY: ONTOGENY OF ITS SYNTHESIS AND ITS ROLE IN SYSTEMIC ANAPHYLAXIS . [Doctoral Dissertation]. University of Arizona; 1974. Available from: http://hdl.handle.net/10150/290363

University of Arizona

25. Meng, Aniko Litasi, 1941-. ONTOGENY OF IMMUNOGLOBULIN E INDUCED ANAPHYLACTIC REACTIONS IN THE RABBIT .

Degree: 1978, University of Arizona

URL: http://hdl.handle.net/10150/290460

Subjects/Keywords: Immunoglobulin E.; Rabbits.

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APA (6^th Edition):

Meng, Aniko Litasi, 1. (1978). ONTOGENY OF IMMUNOGLOBULIN E INDUCED ANAPHYLACTIC REACTIONS IN THE RABBIT . (Doctoral Dissertation). University of Arizona. Retrieved from http://hdl.handle.net/10150/290460

Chicago Manual of Style (16^th Edition):

Meng, Aniko Litasi, 1941-. “ONTOGENY OF IMMUNOGLOBULIN E INDUCED ANAPHYLACTIC REACTIONS IN THE RABBIT .” 1978. Doctoral Dissertation, University of Arizona. Accessed March 01, 2021. http://hdl.handle.net/10150/290460.

MLA Handbook (7^th Edition):

Meng, Aniko Litasi, 1941-. “ONTOGENY OF IMMUNOGLOBULIN E INDUCED ANAPHYLACTIC REACTIONS IN THE RABBIT .” 1978. Web. 01 Mar 2021.

Vancouver:

Meng, Aniko Litasi 1. ONTOGENY OF IMMUNOGLOBULIN E INDUCED ANAPHYLACTIC REACTIONS IN THE RABBIT . [Internet] [Doctoral dissertation]. University of Arizona; 1978. [cited 2021 Mar 01]. Available from: http://hdl.handle.net/10150/290460.

Council of Science Editors:

Meng, Aniko Litasi 1. ONTOGENY OF IMMUNOGLOBULIN E INDUCED ANAPHYLACTIC REACTIONS IN THE RABBIT . [Doctoral Dissertation]. University of Arizona; 1978. Available from: http://hdl.handle.net/10150/290460

26. Rettig, Trisha Ann. Determination of B cell IgH repertoire changes after immunization and spaceflight modeling.

Degree: PhD, Division of Biology, 2018, Kansas State University

URL: http://hdl.handle.net/2097/38796

► Antibodies are an essential part of the immune system. Each B cell, a type of white blood cell, produces a unique antibody. This antibody molecule… (more)

▼ Antibodies are an essential part of the immune system. Each B cell, a type of white blood cell, produces a unique antibody. This antibody molecule is comprised of two identical light chains and two identical heavy chains. Each chain has a variable region, which is responsible for antigen binding, and a constant region, which is responsible for effector function in the host. The variable region in the heavy chain is composed of three gene segments, the variable (V), diversity (D), and joining (J) gene segments. The light chain is composed of only V- and J-gene segments. Each immunoglobulin locus contains multiple versions of each gene segment, ranging from over 130 possible V gene segments in the heavy chain to four possible J-gene segments in both the heavy and kappa light chain. The recombination of gene segments occurs in the germline DNA and results in the formation of the unique antibody. The diversity and binding abilities of the antibodies are important for a proper and robust immunological response. Of importance to binding and specificity is the complementary determining region three (CDR3) which plays a major role in determining specificity and antibody-antigen binding. Due to its uniqueness, is used as a measure of diversity in the repertoire. In this work, I used Illumina MiSeq 2x300nt high-throughput sequencing to assess the mouse splenic transcriptome. The work I present here shows the splenic immunoglobulin gene repertoire from unchallenged, unvaccinated conventionally housed mice, mice flown aboard the International Space Station (ISS), and mice challenged with tetanus toxoid (TT) and/or adjuvant (CpG) and subjected to skeletal unloading by antiorthostatic suspension (AOS). AOS is used to induce some of the physiological changes that parallel those that occur during space flight. The characterization of the repertoire includes analysis of V-, D-, and J-gene segment usage, constant region usage, V- and J-gene segment pairing, and CDR3 length and usage. The work included validation of the methodology needed for tissue preparation and storage aboard the ISS, showing that the data obtained was similar to those used in standard ground-based methodologies (Chapter 2). I further validated our nonamplified sequencing methodology with comparisons to methods that use amplification as part of the process (Chapter 3). My work characterized the antibody repertoire of the conventionally housed C57BL/6J mouse (Chapter 4), an important mouse strain in the field of immunology, and demonstrated the homogeneity of gene segment usage in unchallenged animals. We also demonstrated that short duration (~21 days) space flight does not significantly alter the antibody repertoire (Chapter 5). The work culminates in an AOS study to assess changes to the B-cell immunoglobulin repertoire after vaccination with TT and/or CpG. The results show that changes to V-, D-, and J-gene segment usage occur after antigen challenge with AOS causing decreased class switching and frequency of plasma cells. Tetanus toxoid challenge decreased… Advisors/Committee Members: Stephen Chapes.

Subjects/Keywords: Antibody repertoire; Bioinformatics; Spaceflight; Immunoglobulin; Mouse; Microgravity

10 more images…

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APA (6^th Edition):

Rettig, T. A. (2018). Determination of B cell IgH repertoire changes after immunization and spaceflight modeling. (Doctoral Dissertation). Kansas State University. Retrieved from http://hdl.handle.net/2097/38796

Chicago Manual of Style (16^th Edition):

Rettig, Trisha Ann. “Determination of B cell IgH repertoire changes after immunization and spaceflight modeling.” 2018. Doctoral Dissertation, Kansas State University. Accessed March 01, 2021. http://hdl.handle.net/2097/38796.

MLA Handbook (7^th Edition):

Rettig, Trisha Ann. “Determination of B cell IgH repertoire changes after immunization and spaceflight modeling.” 2018. Web. 01 Mar 2021.

Vancouver:

Rettig TA. Determination of B cell IgH repertoire changes after immunization and spaceflight modeling. [Internet] [Doctoral dissertation]. Kansas State University; 2018. [cited 2021 Mar 01]. Available from: http://hdl.handle.net/2097/38796.

Council of Science Editors:

Rettig TA. Determination of B cell IgH repertoire changes after immunization and spaceflight modeling. [Doctoral Dissertation]. Kansas State University; 2018. Available from: http://hdl.handle.net/2097/38796

University of Canterbury

27. Plummer, Ben Thomas. The influence of pH on the binding of immunoglobulin G to staphylococcal protein A.

Degree: Masters of Engineering, Chemical Engineering, 2013, University of Canterbury

URL: http://dx.doi.org/10.26021/3167

► The interaction between protein A and immunoglobulin G (IgG) was studied at a variety of pH values using a surface plasmon resonance (SPR) device, which… (more)

▼ The interaction between protein A and immunoglobulin G (IgG) was studied at a variety of pH values using a surface plasmon resonance (SPR) device, which provides real time kinetic data without labelling or molecular alteration. This study was carried out due to the large scale use of Protein A affinity chromatography for the purification of IgG for pharmaceutical purposes, and is one of the most costly steps in the purification process. The results produced were largely in line with those produced in previous literature with binding remaining strong between pH 7.4 and 5.0, although the association rate decreased as pH decreased. Below pH 5.0, the rate of IgG elution markedly increased, with pH 3.5 showing near full elution seconds after the association phase of the SPR interaction finished. Problems were encountered with non-specific binding between the SPR sensor chip and IgG occurring under a variety of conditions, requiring various remedies. However, no complete interactions were successfully carried out under pH 5.0, so the results obtained below this value were obtained by binding at pH 7.4 and then elution at the desired pH. The data showed binding behaviour that was most successfully explained by a three-site model, each with a binding ratio of 1:1. The binding ratio is questionable given that Protein A and IgG typically bind at a ratio of 1:2 but may be explained by the sites being independent of one another and thus no secondary attachment is observed. A variety of models were fitted to the data but only two- and three-site models fitted the experimental data, with the three-site model being a more accurate and robust fit across pH changes. A multiple site model seems intuitively correct given the six different binding sites that Protein A has for interaction with IgG. The models produced have potential applications in a larger model of Protein A affinity chromatography, although a number of additional factors would need to be taken into account, such as mass transfer effects and the IgG concentration gradient.

Subjects/Keywords: Immunoglobulin; Protein A; Staphylococcal; Binding; pH

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Plummer, B. T. (2013). The influence of pH on the binding of immunoglobulin G to staphylococcal protein A. (Masters Thesis). University of Canterbury. Retrieved from http://dx.doi.org/10.26021/3167

Chicago Manual of Style (16^th Edition):

Plummer, Ben Thomas. “The influence of pH on the binding of immunoglobulin G to staphylococcal protein A.” 2013. Masters Thesis, University of Canterbury. Accessed March 01, 2021. http://dx.doi.org/10.26021/3167.

MLA Handbook (7^th Edition):

Plummer, Ben Thomas. “The influence of pH on the binding of immunoglobulin G to staphylococcal protein A.” 2013. Web. 01 Mar 2021.

Vancouver:

Plummer BT. The influence of pH on the binding of immunoglobulin G to staphylococcal protein A. [Internet] [Masters thesis]. University of Canterbury; 2013. [cited 2021 Mar 01]. Available from: http://dx.doi.org/10.26021/3167.

Council of Science Editors:

Plummer BT. The influence of pH on the binding of immunoglobulin G to staphylococcal protein A. [Masters Thesis]. University of Canterbury; 2013. Available from: http://dx.doi.org/10.26021/3167

University of British Columbia

28. Weaver, Michael Stanley. Characterization of idiotype interactions during the immune response to ferredoxin. idiotype and epitope specific interactions determine the outcome of challenge with antigen.

Degree: PhD, Microbiology and Immunology, 1982, University of British Columbia

URL: http://hdl.handle.net/2429/24381

► Anti-idiotype antisera were raised in rabbits to two monoclonal antibodies, Fd-1 and Fd-2, with specificity for each of the two antigenic epitopes found on the… (more)

Subjects/Keywords: Ferredoxin; Immunoglobulin idiotypes

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Weaver, M. S. (1982). Characterization of idiotype interactions during the immune response to ferredoxin. idiotype and epitope specific interactions determine the outcome of challenge with antigen. (Doctoral Dissertation). University of British Columbia. Retrieved from http://hdl.handle.net/2429/24381

Chicago Manual of Style (16^th Edition):

Weaver, Michael Stanley. “Characterization of idiotype interactions during the immune response to ferredoxin. idiotype and epitope specific interactions determine the outcome of challenge with antigen.” 1982. Doctoral Dissertation, University of British Columbia. Accessed March 01, 2021. http://hdl.handle.net/2429/24381.

MLA Handbook (7^th Edition):

Weaver, Michael Stanley. “Characterization of idiotype interactions during the immune response to ferredoxin. idiotype and epitope specific interactions determine the outcome of challenge with antigen.” 1982. Web. 01 Mar 2021.

Vancouver:

Weaver MS. Characterization of idiotype interactions during the immune response to ferredoxin. idiotype and epitope specific interactions determine the outcome of challenge with antigen. [Internet] [Doctoral dissertation]. University of British Columbia; 1982. [cited 2021 Mar 01]. Available from: http://hdl.handle.net/2429/24381.

Council of Science Editors:

Weaver MS. Characterization of idiotype interactions during the immune response to ferredoxin. idiotype and epitope specific interactions determine the outcome of challenge with antigen. [Doctoral Dissertation]. University of British Columbia; 1982. Available from: http://hdl.handle.net/2429/24381

Vanderbilt University

29. Richmond, Bradley Winston. Airway Bacteria Drive a Progressive COPD-Like Phenotype in Mice with Polymeric Immunoglobulin Receptor Deficiency.

Degree: PhD, Cell and Developmental Biology, 2017, Vanderbilt University

URL: http://hdl.handle.net/1803/10456

► Mechanisms driving persistent airway inflammation in chronic obstructive pulmonary disease (COPD) are incompletely understood. As secretory immunoglobulin A (SIgA) deficiency in small airways has been… (more)

Subjects/Keywords: polymeric immunoglobulin receptor; secretory immunoglobulin A; chronic obstructive pulmonary disease; mucosal immunity

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Richmond, B. W. (2017). Airway Bacteria Drive a Progressive COPD-Like Phenotype in Mice with Polymeric Immunoglobulin Receptor Deficiency. (Doctoral Dissertation). Vanderbilt University. Retrieved from http://hdl.handle.net/1803/10456

Chicago Manual of Style (16^th Edition):

Richmond, Bradley Winston. “Airway Bacteria Drive a Progressive COPD-Like Phenotype in Mice with Polymeric Immunoglobulin Receptor Deficiency.” 2017. Doctoral Dissertation, Vanderbilt University. Accessed March 01, 2021. http://hdl.handle.net/1803/10456.

MLA Handbook (7^th Edition):

Richmond, Bradley Winston. “Airway Bacteria Drive a Progressive COPD-Like Phenotype in Mice with Polymeric Immunoglobulin Receptor Deficiency.” 2017. Web. 01 Mar 2021.

Vancouver:

Richmond BW. Airway Bacteria Drive a Progressive COPD-Like Phenotype in Mice with Polymeric Immunoglobulin Receptor Deficiency. [Internet] [Doctoral dissertation]. Vanderbilt University; 2017. [cited 2021 Mar 01]. Available from: http://hdl.handle.net/1803/10456.

Council of Science Editors:

Richmond BW. Airway Bacteria Drive a Progressive COPD-Like Phenotype in Mice with Polymeric Immunoglobulin Receptor Deficiency. [Doctoral Dissertation]. Vanderbilt University; 2017. Available from: http://hdl.handle.net/1803/10456

30. Audrey de Souza Marquez. Dosagem de imunoglobulinas IgG e IgE totais e específicas, proteínas séricas, HDL colesterol e imunocomplexos na paracoccidioidomicose aguda e crônica.

Degree: 2007, Universidade Estadual de Londrina

URL: http://www.bibliotecadigital.uel.br/document/?code=vtls000125817

►

A Paracoccidioidomicose (PCM), causada pelo fungo dimórfico Paracoccodioides brasiliensis, apresenta duas formas clínicas distintas: forma aguda (AF) e forma crônica (CF). A AF ocorre principalmente… (more)

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A Paracoccidioidomicose (PCM), causada pelo fungo dimórfico Paracoccodioides brasiliensis, apresenta duas formas clínicas distintas: forma aguda (AF) e forma crônica (CF). A AF ocorre principalmente em indivíduos jovens e é mais grave e rara enquanto que a CF acomete, sobretudo, homens adultos e em geral de forma menos grave. Os casos de maior gravidade relacionam-se com a depressão da resposta imune celular, a ativação policlonal de células B e o desvio da resposta imune para Th2. Diversos componentes solúveis liberados pelo fungo, como a gp-43, assim como a presença de imuno complexos circulantes tem sido associados ao desvio de resposta e maior gravidade da PCM. O objetivo do presente trabalho foi determinar marcadores moleculares de diferenciação entre as duas formas da doença. Considerando as dificuldades em se estabelecer rotinas sorológicas simples, rápidas e com antígenos padronizados para o diagnóstico laboratorial ambulatorial da PCM e acompanhamento de tratamento, realizou-se inicialmente a correlação das alterações observadas nas frações de eletroforese de proteínas com a dosagem de IgG e IgE totais e HDL colesterol. Foram analisadas 30 amostras de soros de pacientes com CF PCM, 12 de AF PCM e 44 de doadores normais (NHS) por eletroforese e por ensaio imunoenzimático (ELISA). Na segunda etapa foram investigados os níveis séricos de IgG e IgE total e específicas, IC IgG-IgE e IC IgG-gp43 através de ELISA em soro de pacientes com CF PCM (22), AF PCM (12) e NHS (29). Os resultados demonstraram alterações nas frações de proteínas e que existem correlações positivas entre a fração beta e gama-globulinas ou alfa-1 globulinas, gama e alfa-1 globulinas e entre gama-globulinas e níveis de IgE total. Concluímos pelo trabalho que existem diferenças entre as duas formas por alterações nas frações alfa-1 e gama globulinas e que existe diferença na interpretação dos resultados de albumina quando analisados em porcentagem ou níveis absolutos e que o HDL colesterol não contribui para as elevações observadas na fração alfa-1 globulinas na PCM. Os resultados também confirmam que os níveis séricos elevados de IgG e IgE total e IgG e IgE específicas e IC IgG-gp43 estão associados com a forma mais grave da doença e este trabalho introduz pela primeira vez a presença de IgG-IgE IC diferenciando a forma aguda da PCM da crônica.

Paracoccidioidomycosis (PCM), caused by the dimorphic fungus Paracoccidioides brasiliensis, presents two different clinical forms: acute form (AF) and chronic form (CF). The AF occurs particularly in young individuals and is more severe and rare while the CF involves, mainly, male adults and a more benign form, in general. The more severe cases are related to the depression of cellular immune response, polyclonal activation of B cells and to a Th2 cellular immunity deviation. Several soluble components are liberated by the fungus, as gp-43, as well as the presence of circulation immune complexes (IC) has benn associated to the deviation of immune response and greater severity in PCM. The aim of this…

Advisors/Committee Members: Eiko Nakagawa Itano ., Nelson Figueiredo Mendes, Márcia Cristina Furlaneto, Mario Augusto Ono, Emerson José Venâncio.

Subjects/Keywords: Paracoccidioides brasiliensis; Imunoglobulina G; Imunoglobulina E; Microbiologia; Paracoccidioides brasiliensis; Immunoglobulin G; Immunoglobulin E

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Marquez, A. d. S. (2007). Dosagem de imunoglobulinas IgG e IgE totais e específicas, proteínas séricas, HDL colesterol e imunocomplexos na paracoccidioidomicose aguda e crônica. (Thesis). Universidade Estadual de Londrina. Retrieved from http://www.bibliotecadigital.uel.br/document/?code=vtls000125817

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Marquez, Audrey de Souza. “Dosagem de imunoglobulinas IgG e IgE totais e específicas, proteínas séricas, HDL colesterol e imunocomplexos na paracoccidioidomicose aguda e crônica.” 2007. Thesis, Universidade Estadual de Londrina. Accessed March 01, 2021. http://www.bibliotecadigital.uel.br/document/?code=vtls000125817.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Marquez, Audrey de Souza. “Dosagem de imunoglobulinas IgG e IgE totais e específicas, proteínas séricas, HDL colesterol e imunocomplexos na paracoccidioidomicose aguda e crônica.” 2007. Web. 01 Mar 2021.

Vancouver:

Marquez AdS. Dosagem de imunoglobulinas IgG e IgE totais e específicas, proteínas séricas, HDL colesterol e imunocomplexos na paracoccidioidomicose aguda e crônica. [Internet] [Thesis]. Universidade Estadual de Londrina; 2007. [cited 2021 Mar 01]. Available from: http://www.bibliotecadigital.uel.br/document/?code=vtls000125817.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Marquez AdS. Dosagem de imunoglobulinas IgG e IgE totais e específicas, proteínas séricas, HDL colesterol e imunocomplexos na paracoccidioidomicose aguda e crônica. [Thesis]. Universidade Estadual de Londrina; 2007. Available from: http://www.bibliotecadigital.uel.br/document/?code=vtls000125817

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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