subject:(Immune system)

Rutgers University

1. Glass, Ruth M., 1989-. T-cell-mediated maternal immune activation during pregnancy: effect on cognitive function in offspring varying in genetic background.

Degree: PhD, Psychology, 2017, Rutgers University

URL: https://rucore.libraries.rutgers.edu/rutgers-lib/55480/

► Stimulation of the immune system during pregnancy, known as maternal immune activation (MIA), can cause long-lasting neurobiological and behavioral changes in the offspring. This phenomenon… (more)

▼ Stimulation of the immune system during pregnancy, known as maternal immune activation (MIA), can cause long-lasting neurobiological and behavioral changes in the offspring. This phenomenon has been implicated in the etiology of developmental psychiatric disorders, such as autism and schizophrenia. Much of this evidence is predicated on animal models that rely on activation of the innate immune system using bacterial agents such as LPS and/or viral mimics such Poly I:C, both of which act through toll-like receptors. Fewer studies have examined the role of direct activation of maternal T-cells during pregnancy and whether this also results in altered neurobiological and behavioral outcomes in offspring. Bacterial ‘superantigens’, such as Staphylococcal Enterotoxin A and B (SEA; SEB), are microbial proteins that activate CD4+ T-cells and cause prominent T-cell proliferation and cytokine production. We injected pregnant and non-pregnant adult female C57BL/6 and Balb/c mice with 5μg of SEA, SEB, or 0.9% saline, and measured splenic T-cell-derived cytokine concentrations (viz., IL-2, IFN-γ, IL-6, and IL-4) 2 hours later; animals injected with SEA were also measured for splenic concentrations of TNF-α and IL-17A. Half of the injected pregnant animals were brought to term, and their offspring were tested on a series of cognitive tasks starting at six weeks of age (postnatal day 42 [P42]). These tasks included a social interaction task, the elevated plus maze (EPM), an object recognition (OR) task, prepulse inhibition (PPI) of sensorimotor gating, and the Morris water maze (MWM). Results showed that SEA and SEB induced significant concentrations of all measured cytokines, and in particular IFN-γ, in both strains of pregnant mice when compared to controls. While C57BL/6 animals responded with significantly greater concentrations of most proinflammatory cytokines to SEA exposure, Balb/c mice had greater cytokine concentrations to SEB exposure. In addition, pregnant animals exhibited reduced production of proinflammatory cytokines, and in the case of Balb/c SEB-injected mice, increased anti-inflammatory cytokine IL-4. Behavioral results showed distinct phenotypes among offspring from SEA- or SEB-injected mothers. C57BL/6 offspring from SEA-injected mothers displayed decreases in social behavior and spatial learning, and increases in anxiety, locomotion, interest in a novel object, short-term spatial memory, and depressive-like behaviors. Balb/c offspring from SEB-injected mothers displayed decreases in spatial learning, and increases in social behavior, anxiety, sensorimotor gating abilities, and depressive like-behaviors. Overall, through the novel use of SEA and SEB as prenatal immune challenges, we were able to elicit significant cytokine production in the mothers and distinct behavioral profiles in the offspring that both mirrors and diverges from previous models of maternal immune activation in important ways. We conclude that T-cell-mediated maternal immune activation is a valid and valuable model for studying the effects… Advisors/Committee Members: Kusnecov, Alexander W (chair), Stromswold, Karin (internal member), Wagner, George (internal member), Tonelli, Leornardo (outside member), Tonelli, Leonardo (outside member), School of Graduate Studies.

Subjects/Keywords: Immune system

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APA (6^th Edition):

Glass, Ruth M., 1. (2017). T-cell-mediated maternal immune activation during pregnancy: effect on cognitive function in offspring varying in genetic background. (Doctoral Dissertation). Rutgers University. Retrieved from https://rucore.libraries.rutgers.edu/rutgers-lib/55480/

Chicago Manual of Style (16^th Edition):

Glass, Ruth M., 1989-. “T-cell-mediated maternal immune activation during pregnancy: effect on cognitive function in offspring varying in genetic background.” 2017. Doctoral Dissertation, Rutgers University. Accessed August 24, 2019. https://rucore.libraries.rutgers.edu/rutgers-lib/55480/.

MLA Handbook (7^th Edition):

Glass, Ruth M., 1989-. “T-cell-mediated maternal immune activation during pregnancy: effect on cognitive function in offspring varying in genetic background.” 2017. Web. 24 Aug 2019.

Vancouver:

Glass, Ruth M. 1. T-cell-mediated maternal immune activation during pregnancy: effect on cognitive function in offspring varying in genetic background. [Internet] [Doctoral dissertation]. Rutgers University; 2017. [cited 2019 Aug 24]. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/55480/.

Council of Science Editors:

Glass, Ruth M. 1. T-cell-mediated maternal immune activation during pregnancy: effect on cognitive function in offspring varying in genetic background. [Doctoral Dissertation]. Rutgers University; 2017. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/55480/

McMaster University

2. Quillier, Ophélie. Proactive immunity: commensal bacteria interact with the immune system to fight Pseudomonas aeruginosa.

Degree: MSc, 2018, McMaster University

URL: http://hdl.handle.net/11375/23424

►

Multi-drug resistant Pseudomonas aeruginosa has become an increasing threat. A threat compounded by the fact that the pipeline of antimicrobial discovery continues to lose effectiveness.… (more)

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Multi-drug resistant Pseudomonas aeruginosa has become an increasing threat. A threat compounded by the fact that the pipeline of antimicrobial discovery continues to lose effectiveness. It is urgent that we identify new strategies to eliminate this and other multi-drug resistant pathogens. Meanwhile, we know that the resident bacteria of the respiratory tract interact with host cells to eliminate incoming threats. The goal of this project is to understand the interactions at play in the microbiota of the respiratory tract and identify the specific commensal bacteria that inhibit P. aeruginosa in the presence of host cells. Using a nasopharyngeal cell culture screen, we were able to identify several human commensals capable of inhibiting the growth of antibiotic-resistant P. aeruginosa in a host-dependent manner. It was also established that this phenotype can be reproduced in more complex systems, including a murine lung slice model, and that the elimination of the pathogen is dependent on the presence of living bacteria, mediated by a secreted factor. We believe that the presence of these commensals has an immunomodulatory effect on the host. By characterizing the cytokines and chemokines produced by the host cells in response to the presence of these commensals, we have shown that these bacteria modify the immune response of the host to the pathogen. Finally, having failed to develop a mouse model of infection, we have determined that the observed phenotype is not a direct action of the host cells, nor the result of hydrogen peroxide secretion. We have further characterized the bacterial strains using genome assembly. This study has confirmed that commensal bacteria create a unique immune environment that contributes to the clearance of pathogens. Identifying bacteria and bacterial products capable of stimulating host defenses and modulating inflammation could provide a new therapeutic approach to reducing infection susceptibility in high-risk patients.

Thesis

Master of Science (MSc)

Antibiotics have for decades facilitated the cure of infections caused by pathogens of all kinds. Unfortunately, repeated exposure to antibiotics has rendered some pathogens highly resistant to traditional treatment. One notorious multi-drug resistant pathogen is Pseudomonas aeruginosa, now responsible for 10-15% of hospital-acquired respiratory infections. In this project we investigate the potential that lies in using commensal bacteria that exist in the microbiota of our respiratory tract to fight against pathogens that no longer respond to antibiotics. Stringent experiments with various models have revealed bacteria capable of killing Pseudomonas aeruginosa and helped us understand the mechanism of inhibition as well as the interactions of the bacteria with the immune system. Our results show that some bacteria of the microbiota are effective against Pseudomonas aeruginosa and that this line of study holds promise for the development of a new arsenal against a growing number of threatening pathogens.

Advisors/Committee Members: Surette, Michael, Biochemistry and Biomedical Sciences.

Subjects/Keywords: microbiome; immune system

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APA (6^th Edition):

Quillier, O. (2018). Proactive immunity: commensal bacteria interact with the immune system to fight Pseudomonas aeruginosa. (Masters Thesis). McMaster University. Retrieved from http://hdl.handle.net/11375/23424

Chicago Manual of Style (16^th Edition):

Quillier, Ophélie. “Proactive immunity: commensal bacteria interact with the immune system to fight Pseudomonas aeruginosa.” 2018. Masters Thesis, McMaster University. Accessed August 24, 2019. http://hdl.handle.net/11375/23424.

MLA Handbook (7^th Edition):

Quillier, Ophélie. “Proactive immunity: commensal bacteria interact with the immune system to fight Pseudomonas aeruginosa.” 2018. Web. 24 Aug 2019.

Vancouver:

Quillier O. Proactive immunity: commensal bacteria interact with the immune system to fight Pseudomonas aeruginosa. [Internet] [Masters thesis]. McMaster University; 2018. [cited 2019 Aug 24]. Available from: http://hdl.handle.net/11375/23424.

Council of Science Editors:

Quillier O. Proactive immunity: commensal bacteria interact with the immune system to fight Pseudomonas aeruginosa. [Masters Thesis]. McMaster University; 2018. Available from: http://hdl.handle.net/11375/23424

3. Purushothaman, Divya. Regulation of activated T cell death; -.

Degree: Chemical and Biotechnology, 2014, SASTRA University

URL: http://shodhganga.inflibnet.ac.in/handle/10603/22846

Abstract included

Reference p116-134, List of publications p114-115, List of abbreviations p135-137, Summary included

Advisors/Committee Members: Sarin, Apurva.

Subjects/Keywords: Immune System; T cell death

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APA (6^th Edition):

Purushothaman, D. (2014). Regulation of activated T cell death; -. (Thesis). SASTRA University. Retrieved from http://shodhganga.inflibnet.ac.in/handle/10603/22846

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Purushothaman, Divya. “Regulation of activated T cell death; -.” 2014. Thesis, SASTRA University. Accessed August 24, 2019. http://shodhganga.inflibnet.ac.in/handle/10603/22846.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Purushothaman, Divya. “Regulation of activated T cell death; -.” 2014. Web. 24 Aug 2019.

Vancouver:

Purushothaman D. Regulation of activated T cell death; -. [Internet] [Thesis]. SASTRA University; 2014. [cited 2019 Aug 24]. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/22846.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Purushothaman D. Regulation of activated T cell death; -. [Thesis]. SASTRA University; 2014. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/22846

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Aberdeen

4. Mitra, Suman. Zebrafish adaptive immunity : progress with defining Th-type responses and cells.

Degree: 2011, University of Aberdeen

URL: http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=165216 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.540337

► Our initial studies reported on the cloning and characterization of FoxP3 (T regulatory cell specific) for the first time in any teleost species along with… (more)

Subjects/Keywords: 571.1; Zebra danio : Immune system

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APA (6^th Edition):

Mitra, S. (2011). Zebrafish adaptive immunity : progress with defining Th-type responses and cells. (Doctoral Dissertation). University of Aberdeen. Retrieved from http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=165216 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.540337

Chicago Manual of Style (16^th Edition):

Mitra, Suman. “Zebrafish adaptive immunity : progress with defining Th-type responses and cells.” 2011. Doctoral Dissertation, University of Aberdeen. Accessed August 24, 2019. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=165216 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.540337.

MLA Handbook (7^th Edition):

Mitra, Suman. “Zebrafish adaptive immunity : progress with defining Th-type responses and cells.” 2011. Web. 24 Aug 2019.

Vancouver:

Mitra S. Zebrafish adaptive immunity : progress with defining Th-type responses and cells. [Internet] [Doctoral dissertation]. University of Aberdeen; 2011. [cited 2019 Aug 24]. Available from: http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=165216 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.540337.

Council of Science Editors:

Mitra S. Zebrafish adaptive immunity : progress with defining Th-type responses and cells. [Doctoral Dissertation]. University of Aberdeen; 2011. Available from: http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=165216 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.540337

5. Sakelliou, Alexandra. Μεταβολισμός και άσκηση.

Degree: 2017, National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ)

URL: http://hdl.handle.net/10442/hedi/39674

►

We used thiol-based antioxidant supplementation (n-acetylcysteine, NAC) to determine whether immune mobilisation following skeletal muscle micro-trauma induced by exercise is redox-sensitive in healthy humans. According… (more)

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We used thiol-based antioxidant supplementation (n-acetylcysteine, NAC) to determine whether immune mobilisation following skeletal muscle micro-trauma induced by exercise is redox-sensitive in healthy humans. According to a two-trial, double-blind, crossover, repeated measures design, 10 young men received either placebo or NAC (20 mg/kg/day) immediately after a muscle-damaging exercise protocol (300 eccentric contractions) and for eight consecutive days. Blood sampling and performance assessments were performed pre-exercise, post-exercise and daily throughout recovery. NAC reduced the decline of reduced glutathione in erythrocytes and the increase of plasma protein carbonyls, serum TAC and erythrocyte oxidized glutathione, TBARS and catalase activity during recovery thereby altering post-exercise redox status. The rise of muscle damage and inflammatory markers (muscle strength, creatine kinase activity, CRP, pro-inflammatory cytokines, adhesion molecules) was less pronounced in NAC during the first phase of recovery. The rise of leukocyte and neutrophil count was decreased by NAC post-exercise. Results on immune cell sub-populations obtained by flow cytometry indicated that NAC ingestion reduced the exercise-induced rise of total macrophages, HLA+ macrophages, and 11B+ macrophages and abolished the exercise-induced up-regulation of B lymphocytes. Natural killer cells declined only in PLA immediately post-exercise. These results indicate that thiol-based antioxidant supplementation blunts immune cell mobilisation in response to exercise-induced inflammation suggesting that leukocyte mobilization may be under redoxdependent regulation.

Η Ν ακετυλο-κυστείνη (NAC) είναι ένα αντιοξειδωτικό συμπλήρωμα που χρησιμοποιήθηκε για να διερευνήσει εάν η ενεργοποίηση του ανοσοποιητικού συστήματος που ακολουθεί τη φλεγμονή που επάγεται μέσω της άσκησης είναι οξειδοαναγωγικά εξαρτώμενη. Σε μια διασταυρούμενη, διπλή, τυφλή μελέτη επαναλαμβανόμενων μετρήσεων, 10 υγιείς άρρενες εθελοντές μετά το πέρας του πρωτόκολλου μυϊκής καταστροφής (300 έκκεντρες επαναλήψεις) έλαβαν N-ακετυλοκυστείνη (NAC) ή Placebo για οκτώ συνεχόμενες ημέρες. Οι μετρήσεις αίματος και μυϊκής απόδοσης πραγματοποιήθηκαν πριν την άσκηση, αμέσως μετά και καθημερινά κατά το στάδιο της ανάρρωσης. Η χορήγηση NAC στο στάδιο της ανάρρωσης ελάττωσε τη μείωση της γλουταθειόνης στα ερυθρά αιμοσφαίρια και την αύξηση στο πλάσμα των πρωτεινικών καρβονυλίων, της συνολικής αντιοξειδωτικής ικανότητας (TAC), της οξειδωμένης μορφής της γλουταθειόνης (GSSG), τις αντιδραστικές ουσίες του θεοβαρβιτουρικού οξέως (TBARS) και τη δραστικότητα της καταλάσης, μεταβάλλοντας έτσι την οξειδοαναγωγική κατάσταση. Επιπλέον, η χρήση της ΝAC μείωσε τη μυϊκή καταστροφή, την άνοδο των λευκών αιμοσφαιρίων και των ουδετερόφιλων, καθώς και των δεικτών φλεγμονής (μυϊκή δύναμη, κρεατινική κινάση, CRP, προ-φλεγμονώδεις κυτοκίνες, μόρια προσκόλλησης). Οι μετρήσεις των υποπληθυσμών του ανοσοποιητικού συστήματος, όπως καθορίστηκαν από την κυτταρομετρία ροής, απέδειξαν ότι η χορήγηση της NAC εξασθένησε…

Subjects/Keywords: Ανοσοποιητικό σύστημα; Immune system

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APA (6^th Edition):

Sakelliou, A. (2017). Μεταβολισμός και άσκηση. (Thesis). National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ). Retrieved from http://hdl.handle.net/10442/hedi/39674

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Sakelliou, Alexandra. “Μεταβολισμός και άσκηση.” 2017. Thesis, National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ). Accessed August 24, 2019. http://hdl.handle.net/10442/hedi/39674.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Sakelliou, Alexandra. “Μεταβολισμός και άσκηση.” 2017. Web. 24 Aug 2019.

Vancouver:

Sakelliou A. Μεταβολισμός και άσκηση. [Internet] [Thesis]. National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ); 2017. [cited 2019 Aug 24]. Available from: http://hdl.handle.net/10442/hedi/39674.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Sakelliou A. Μεταβολισμός και άσκηση. [Thesis]. National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ); 2017. Available from: http://hdl.handle.net/10442/hedi/39674

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

6. 阿部, 里見. Alloreactivity and immunosuppressive properties of articular chondrocytes from osteoarthritic cartilage.

Degree: 博士（医学）, 2016, Asahikawa Medical University / 旭川医科大学

URL: http://amcor.asahikawa-med.ac.jp/modules/xoonips/detail.php?id=20160630_O463

► PURPOSE:To determine whether articular chondrocytes derived from osteoarthritic knee joints could evoke alloreactive proliferation of peripheral blood mononuclear cells (PBMC) and inhibit mitogenic activity of… (more)

Subjects/Keywords: chondrocytes; immune system; osteoarthritis

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APA (6^th Edition):

阿部, �. (2016). Alloreactivity and immunosuppressive properties of articular chondrocytes from osteoarthritic cartilage. (Thesis). Asahikawa Medical University / 旭川医科大学. Retrieved from http://amcor.asahikawa-med.ac.jp/modules/xoonips/detail.php?id=20160630_O463

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

阿部, 里見. “Alloreactivity and immunosuppressive properties of articular chondrocytes from osteoarthritic cartilage.” 2016. Thesis, Asahikawa Medical University / 旭川医科大学. Accessed August 24, 2019. http://amcor.asahikawa-med.ac.jp/modules/xoonips/detail.php?id=20160630_O463.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

阿部, 里見. “Alloreactivity and immunosuppressive properties of articular chondrocytes from osteoarthritic cartilage.” 2016. Web. 24 Aug 2019.

Vancouver:

阿部 �. Alloreactivity and immunosuppressive properties of articular chondrocytes from osteoarthritic cartilage. [Internet] [Thesis]. Asahikawa Medical University / 旭川医科大学; 2016. [cited 2019 Aug 24]. Available from: http://amcor.asahikawa-med.ac.jp/modules/xoonips/detail.php?id=20160630_O463.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

阿部 �. Alloreactivity and immunosuppressive properties of articular chondrocytes from osteoarthritic cartilage. [Thesis]. Asahikawa Medical University / 旭川医科大学; 2016. Available from: http://amcor.asahikawa-med.ac.jp/modules/xoonips/detail.php?id=20160630_O463

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Gothenburg / Göteborgs Universitet

7. Svahn, Sara L. Effects of dietary fatty acids on the immune system.

Degree: 2015, University of Gothenburg / Göteborgs Universitet

URL: http://hdl.handle.net/2077/39568

► Sepsis is a deadly disease with an increasing incidence worldwide. Today, antimicrobials are the only effective pharmacological treatment. At the same time, bacteria, the pathogens… (more)

▼ Sepsis is a deadly disease with an increasing incidence worldwide. Today, antimicrobials are the only effective pharmacological treatment. At the same time, bacteria, the pathogens behind most cases of sepsis, are becoming more and more resistant to our available antibiotics. A considerable amount of time, effort and money has been spent into finding new drug-candidates for treating sepsis. To date, none has succeeded in clinical trials. Dietary fatty acids affect the immune system. Saturated fatty acids (SFAs) increase the risk for cardiovascular diseases and promote low-grade inflammation, whereas polyunsaturated fatty acids (PUFAs) are beneficial for patients with rheumatoid arthritis and atherosclerosis, being anti-inflammatory. In this thesis, we investigated the effects of dietary fatty acids on the immune system and survival in S. aureus-induced sepsis in mice. Following 8 week of either low fat diet (LFD), high fat diet (HFD) rich in SFAs (HFD-S) or HFD rich in PUFAs (HFD-P) mice were inoculated with S. aureus to induce sepsis or investigated for mechanistic studies. Mice fed HFD-P had a better survival in sepsis and lower bacterial load compared with mice fed HFD-S. Further, we found an increased frequency of Ly6G+ neutrophils and CD117+ hematopoietic stem cells in the bone marrow in mice fed HFD-P at uninfected state. Moreover, neutrophils from mice fed HFD-P have an improved migratory capacity. Since dietary manipulations have an effect on the whole organism, we investigated the transcriptome profile in immunologically and metabolically important organs. Remarkably, the spleen showed a major response to HFD-P, i.e., down regulating both the innate and the adaptive immune system. We further investigated the mechanisms behind the increased frequency of neutrophils in mice fed HFD-P and showed an increased level of the major regulator of granulopoiesis, G-CSF, in the bone marrow. Additionally, there was an increased frequency of neutrophils in organs housing the marginated pool of neutrophils, i.e. spleen, liver and bone marrow. Since HFD-P contained different types of PUFAs, both omega-3 and omega-6 PUFAs (ω-3 PUFAs and ω-6 PUFAs), additional investigations aimed to determine which type of fatty acids mediated the beneficial effects. Omega-3 PUFAs were identified as the PUFAs responsible for the positive effects on the immune system and survival in septic infection. In conclusion, our results show that, beyond their well-recognised anti-inflammatory properties, omega-3 PUFAs have immune-modulating properties, as they influence the transcriptome profile in the spleen, increase the frequency of neutrophils in bone marrow, spleen and liver, as well as, improve neutrophil function, making this type of PUFAs a potential supplementary treatment for sepsis.

Subjects/Keywords: dietary fatty acids; immune system

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APA (6^th Edition):

Svahn, S. L. (2015). Effects of dietary fatty acids on the immune system. (Thesis). University of Gothenburg / Göteborgs Universitet. Retrieved from http://hdl.handle.net/2077/39568

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Svahn, Sara L. “Effects of dietary fatty acids on the immune system.” 2015. Thesis, University of Gothenburg / Göteborgs Universitet. Accessed August 24, 2019. http://hdl.handle.net/2077/39568.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Svahn, Sara L. “Effects of dietary fatty acids on the immune system.” 2015. Web. 24 Aug 2019.

Vancouver:

Svahn SL. Effects of dietary fatty acids on the immune system. [Internet] [Thesis]. University of Gothenburg / Göteborgs Universitet; 2015. [cited 2019 Aug 24]. Available from: http://hdl.handle.net/2077/39568.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Svahn SL. Effects of dietary fatty acids on the immune system. [Thesis]. University of Gothenburg / Göteborgs Universitet; 2015. Available from: http://hdl.handle.net/2077/39568

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Gothenburg / Göteborgs Universitet

8. Bennet, Sean. Immunological and Microbiological perspectives on Irritable Bowel Syndrome.

Degree: 2017, University of Gothenburg / Göteborgs Universitet

URL: http://hdl.handle.net/2077/53610

► Abstract Irritable bowel syndrome affects ~11% of the population in the Western world and is characterised by altered bowel habits and abdominal pain. The range… (more)

▼ Abstract Irritable bowel syndrome affects ~11% of the population in the Western world and is characterised by altered bowel habits and abdominal pain. The range of additional symptoms between subjects makes groups of IBS patients heterogeneous. Increased immune activity, altered gut microbiota and diet are implicated in symptom generation though the mechanisms are poorly understood. Moreover, gut microbiota and immune activity interplay in relation to symptoms requires elucidation and while dietary intervention is effective in some patients its impact on gut microbiota is unclear. Most likely, all patients do not share the same symptom generating mechanisms, and thus better means to stratify patients for both research and treatment is required. This thesis aimed to demonstrate how gut microbiota, the immune system and their crosstalk result in symptom generation in IBS patients. Furthermore, we aimed to demonstrate how dietary intervention affects microbiota of the gut and if patient responsiveness to intervention therapy could be predicted by gut microbiota profiles. This thesis demonstrates that a diet low in poorly absorbed carbohydrates (FODMAP) changes the gut microbiota composition and reduces beneficial bacteria in IBS patients. Moreover, the composition of gut microbiota can be used to discriminate patients whose IBS symptoms improved or not after a low FODMAP diet. Additionally, serum or mucosal cytokines cannot be used alone to diagnose IBS. However, a subset of immuno-active patients had comparatively raised serum levels of pro-inflammatory cytokines to healthy subjects and immuno-normal IBS patients, although no major associations between cytokines and symptoms were found. Further, IBS patients had an altered mucosal expression of genes associated with an innate antimicrobial response compared to healthy subjects. The antibacterial gene expression response profiles as well as faecal and mucosal bacterial profiles were different between immuno-active and immuno-normal IBS patients, but were not associated to symptoms. In conclusion, a subset of IBS patients has altered immune activity, deemed by cytokine and innate antimicrobial response profiles, which do not seem to be associated with any specific symptom profile. Further, faecal microbial profiles may be used to identify responders to low FODMAP diet therapy but negative impact of the diet on beneficial bacteria requires further investigation. Thus, this thesis has identified novel subgroups of IBS patients based on underlying mechanisms which may guide development of innovative therapy options.

Subjects/Keywords: IBS; Microbiota; Immune system; FODMAPs

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APA (6^th Edition):

Bennet, S. (2017). Immunological and Microbiological perspectives on Irritable Bowel Syndrome. (Thesis). University of Gothenburg / Göteborgs Universitet. Retrieved from http://hdl.handle.net/2077/53610

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Bennet, Sean. “Immunological and Microbiological perspectives on Irritable Bowel Syndrome.” 2017. Thesis, University of Gothenburg / Göteborgs Universitet. Accessed August 24, 2019. http://hdl.handle.net/2077/53610.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Bennet, Sean. “Immunological and Microbiological perspectives on Irritable Bowel Syndrome.” 2017. Web. 24 Aug 2019.

Vancouver:

Bennet S. Immunological and Microbiological perspectives on Irritable Bowel Syndrome. [Internet] [Thesis]. University of Gothenburg / Göteborgs Universitet; 2017. [cited 2019 Aug 24]. Available from: http://hdl.handle.net/2077/53610.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Bennet S. Immunological and Microbiological perspectives on Irritable Bowel Syndrome. [Thesis]. University of Gothenburg / Göteborgs Universitet; 2017. Available from: http://hdl.handle.net/2077/53610

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Victoria

9. Hoption Cann, Stephen A. The immune system and breast carcinoma : implications of dietary and other associated factors.

Degree: Department of Biology, 2018, University of Victoria

URL: https://dspace.library.uvic.ca//handle/1828/9538

► Introduction: A review of animal and human studies demonstrates that the immune system is a major factor in both the enhancement and inhibition of malignant… (more)

▼ Introduction: A review of animal and human studies demonstrates that the immune system is a major factor in both the enhancement and inhibition of malignant tumour growth. Macrophages, one of the most durable and versatile immune cells, may be key to this immune duality. Macrophages have been observed in particularly high concentrations in and around breast tumours. It has been suggested that these cells generally aid tumour growth, unless activated by an acute infections, immunomodulators or other means. Study l: Using immunohistochemistry and computer-aided image analysis, macrophage concentrations in and around breast tumours were examined. Other pathological tissues were also examined for comparative purposes. Macrophage density was found to correlate positively with the Modified Bloom Richardson (MBR) grade (r = 0.41) and MBR subscore (r = 0.44), suggesting that macrophage concentrations increase as tumours become more aggressive. Similar infiltrations of macrophages were observed in lung, prostate and hyperplastic thyroid tissues; although in these latter tissues, macrophages were generally confined to the tumour periphery. Study II: Iodine has been shown to play many roles in normal human physiology. In addition to its incorporation into thyroid hormones, iodine also has antibiotic and antitumour properties. Epidemiological studies of iodine in breast cancer have not been conducted. In this pilot case-control study, whole blood levels of 10 trace elements (Br, Cr, Fe, I, Mb, Mg, Mn, Se, V, and Zn) and their association with breast cancer was investigated. Other general, medical and dietary characteristics were examined as well. In comparison with iodine levels in Japan, iodine levels in the population under study were considerably lower, with a mean of 28.4 μg/l and a range of 19–35 μg/l. In the univariate logistic regression analysis, a number of significant associations with breast cancer were observed. A high education status (OR = 0.31) and high iron status (OR = 0.15) were associated with reduced risks, whereas previous hysterectomy or ovariectomy was associated with an increased risk of breast cancer (OR = 3.64). In the adjusted multivariate analysis, a high iron status remained associated with a reduced risk (OR = 0.01) and a history of breast pain with an increased risk (OR = 11.25). Conclusion: Understanding the duality of immune function, not only provides insight into cancer progression, but offers two primary avenues for treatment. First, one may down-regulate immune reparative activities, which aid tumour growth. This may be accomplished by using immunosuppressants. A second approach is to take advantage of the large population of tumour-associated immune cells, particularly macrophages, and stimulate these cells into their defensive activities. A wide variety of infectious agents may be used to stimulate this response. Finally, iodine is one immunomodulator that may be used to enhance immune activity for treatment, or alternatively, prevent tumour growth through long-term intake;… Advisors/Committee Members: Van Netten, Johannes Pieter (supervisor).

Subjects/Keywords: Breast carcinoma; Immune system; Dietary

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Hoption Cann, S. A. (2018). The immune system and breast carcinoma : implications of dietary and other associated factors. (Thesis). University of Victoria. Retrieved from https://dspace.library.uvic.ca//handle/1828/9538

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Hoption Cann, Stephen A. “The immune system and breast carcinoma : implications of dietary and other associated factors.” 2018. Thesis, University of Victoria. Accessed August 24, 2019. https://dspace.library.uvic.ca//handle/1828/9538.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Hoption Cann, Stephen A. “The immune system and breast carcinoma : implications of dietary and other associated factors.” 2018. Web. 24 Aug 2019.

Vancouver:

Hoption Cann SA. The immune system and breast carcinoma : implications of dietary and other associated factors. [Internet] [Thesis]. University of Victoria; 2018. [cited 2019 Aug 24]. Available from: https://dspace.library.uvic.ca//handle/1828/9538.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Hoption Cann SA. The immune system and breast carcinoma : implications of dietary and other associated factors. [Thesis]. University of Victoria; 2018. Available from: https://dspace.library.uvic.ca//handle/1828/9538

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universidade Nova

10. Lima, Jorge Natalino Ramos. Immunomodulation in pregnancy and labor.

Degree: 2016, Universidade Nova

URL: http://www.rcaap.pt/detail.jsp?id=oai:run.unl.pt:10362/19609

► RESUMO: A gravidez é um desafio para o sistema imunológico, porque tem de tolerar um feto geneticamente diferente e ao mesmo tempo proteger tanto a… (more)

▼ RESUMO: A gravidez é um desafio para o sistema imunológico, porque tem de tolerar um feto geneticamente diferente e ao mesmo tempo proteger tanto a mãe como o feto contra ameaças biológicas. Isto requer uma regulação estreita dos vários tipos de células do sistema imunitário durante as diferentes fases da gravidez. Estudos recentes revelaram que determinadas subpopulações de células B e células T têm funções reguladoras e são essenciais para a manutenção da tolerância materno-fetal durante as fases iniciais da gravidez. No entanto, não está claro se as células do sistema imunológico materno, especialmente as recém descritas células reguladoras B (Breg) e T (Treg), também podem desempenhar um papel relevante no final da gravidez normal, no parto e no pós-parto. Com o objetivo de analisar o perfil imunológico desde o final da gravidez até ao pós-parto, foram efetuados três estudos observacionais que seguiram mulheres saudáveis, grávidas (n = 43) e não grávidas (como grupo controlo; n = 35), vigiadas na consulta externa do hospital CUF Descobertas. Em primeiro lugar, as contagens no sangue periférico das subpopulações de linfócitos B, considerando o perfil maturativo e incluindo as células Breg, foram analisadas em todas as mulheres grávidas durante o terceiro trimestre da gravidez, no dia do parto (imediatamente após o parto), e no pós-parto (pelo menos 6 semanas após o parto), e comparadas com as do grupo de mulheres não grávidas. Em segundo lugar, a evolução das subpopulações de células Treg foi avaliada no sangue periférico das mulheres grávidas nos mesmos pontos temporais do estudo anterior, e comparadas com as do grupo de controlo. Em terceiro lugar, o efeito do trabalho de parto sobre as subpopulações circulantes de células T, e sobre as subpopulações de células Treg e Breg, foi avaliado no dia do parto, comparando o subgrupo de mulheres grávidas que tiveram o parto por cesariana eletiva (sem trabalho de parto; n = 14), com as que tiveram um parto espontâneo vaginal (após o trabalho de parto; n = 18). A quantificação e a caracterização fenotípica de células B e células T foi efetuada por citometria de fluxo, de acordo com a expressão dos marcadores de superfície celular presentes nas suas diferentes subpopulações. Especificamente, as subpopulações de células B foram caracterizadas no sangue periférico pela expressão de CD19 (marcador de células B), e pela expressão de IgD e CD38 para identificar o perfil maturativo dos linfócitos B de acordo com o sistema de classificação Bm1-5: células B de transição, células B naïve, células B de memória não switched, células B de memória switched entretanto divididas em células pós centro germinativo e células de memória em repouso, e ainda plasmablastos. Os linfócitos Breg foram caracterizados através da expressão de CD24, CD27, CD38, e a produção de IL-10 foi avaliada após a estimulação com acetato de forbolmiristato (PMA), ionóforo de cálcio e lipopolissacárido (LPS) bacteriano. Relativamente às subpopulações de células T de sangue periférico, as células com expressão de… Advisors/Committee Members: Branco, Jorge da Cunha ;, Borrego, Luís Miguel Nabais.

Subjects/Keywords: Pregnancy; Immune system; Ciências Médicas

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Lima, J. N. R. (2016). Immunomodulation in pregnancy and labor. (Thesis). Universidade Nova. Retrieved from http://www.rcaap.pt/detail.jsp?id=oai:run.unl.pt:10362/19609

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Lima, Jorge Natalino Ramos. “Immunomodulation in pregnancy and labor.” 2016. Thesis, Universidade Nova. Accessed August 24, 2019. http://www.rcaap.pt/detail.jsp?id=oai:run.unl.pt:10362/19609.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Lima, Jorge Natalino Ramos. “Immunomodulation in pregnancy and labor.” 2016. Web. 24 Aug 2019.

Vancouver:

Lima JNR. Immunomodulation in pregnancy and labor. [Internet] [Thesis]. Universidade Nova; 2016. [cited 2019 Aug 24]. Available from: http://www.rcaap.pt/detail.jsp?id=oai:run.unl.pt:10362/19609.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Lima JNR. Immunomodulation in pregnancy and labor. [Thesis]. Universidade Nova; 2016. Available from: http://www.rcaap.pt/detail.jsp?id=oai:run.unl.pt:10362/19609

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Adelaide

11. Nicotra, Lauren Louise. Sex differences in allodynia: a complex interaction between 17beta-oestradiol and the innate immune system.

Degree: 2015, University of Adelaide

URL: http://hdl.handle.net/2440/98732

► Chronic pain is a debilitating and costly disease that is well known to preferentially affect women, particularly in their child bearing years. In spite of… (more)

▼ Chronic pain is a debilitating and costly disease that is well known to preferentially affect women, particularly in their child bearing years. In spite of the obvious differences in pathophysiology between the sexes, the underlying mechanisms causing this sex difference in chronic pain have not yet been determined. Contributing to this gap in knowledge is the unrelenting use of preclinical animal pain models along with pain behavioural assessment techniques, which fail to best replicate the clinical pain experience. This translatability issue, along with the continued preferential use of male subjects in preclinical chronic pain investigations has meant that researchers have not yet uncovered what contributes to this sex difference in pain sensitivity, resulting in half the population (females) being inadequately treated for their pain. Among the numerous mechanisms that have been proposed to underlie this sex difference in chronic pain are both the gonadal hormones, particularly 17β-oestradiol, along with the innate immune system. Although seperately known to play a role in chronic pain, prior to this PhD project, the relationship between these two systems had not be investigated in this debilitating condition. Recent evidence however has revealed not only the presence of oestrogen receptors on the key neuroimmune cells in pain responsive regions of the CNS, but also the exaggerated production of pain producing pro-inflammatory mediators in response to their activation. Given therefore that an association between these two pain-producing systems does exist, this PhD project investigated the relationship between 17β-oestradiol and the innate immue system in exaggerated female chronic pain. Furthermore, based on the significant and reported translatability issues relating to preclinical pain studies in light of the currently available chronic pain experimental models and assessment techniques, this study further examined this relatinship for the first time using novel translatable preclinical methodologies. Through a series of key in vitro and in vivo studies our findings not only present and validate a novel preclinical chronic pain model and behavioural assessment technique that better produces and examines a preclincal neuropathy, but our findings also substantiate previous work demonstrating a significant role of 17β-oestradiol in chronic pain. Importantly this PhD project reveals for the first time not only the capability of the oestrogens to directly bind to key innate immune signalling receptors involved in chronic pain, but that 17β-oestradiol priming of CNS innate immune cells via such direct binding is in part responsible for the exaggerated female pain phenotype. Overall, the findings of this body of work highlight a fundamental difference in chronic pain pathophysiology between the sexes and further emphasize the importance of treating chronic pain in women during their reproductive years differently from prepubesent female, postmenopausal and male chronic pain sufferers. Advisors/Committee Members: Hutchinson, Mark Rowland (advisor), Rolan, Paul Edward (advisor), School of Medicine (school).

Subjects/Keywords: allodynia; sex differences; immune system

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Nicotra, L. L. (2015). Sex differences in allodynia: a complex interaction between 17beta-oestradiol and the innate immune system. (Thesis). University of Adelaide. Retrieved from http://hdl.handle.net/2440/98732

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Nicotra, Lauren Louise. “Sex differences in allodynia: a complex interaction between 17beta-oestradiol and the innate immune system.” 2015. Thesis, University of Adelaide. Accessed August 24, 2019. http://hdl.handle.net/2440/98732.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Nicotra, Lauren Louise. “Sex differences in allodynia: a complex interaction between 17beta-oestradiol and the innate immune system.” 2015. Web. 24 Aug 2019.

Vancouver:

Nicotra LL. Sex differences in allodynia: a complex interaction between 17beta-oestradiol and the innate immune system. [Internet] [Thesis]. University of Adelaide; 2015. [cited 2019 Aug 24]. Available from: http://hdl.handle.net/2440/98732.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Nicotra LL. Sex differences in allodynia: a complex interaction between 17beta-oestradiol and the innate immune system. [Thesis]. University of Adelaide; 2015. Available from: http://hdl.handle.net/2440/98732

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

12. Al-Ishaq, Rand Jihad. Functional role of polysaccharide intercellular adhesin during Staphylococcus epidermidis biofilm interaction with the innate immune system.

Degree: PhD, 2013, Swansea University

URL: https://cronfa.swan.ac.uk/Record/cronfa42878 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.678490

► Synthesis of polysaccharide intercellular adhesin (PIA), accumulation associated protein (Aap) and extracellular matrix binding protein (Embp) are major mechanisms used by Staphylococcus epidermidisto evade immunity… (more)

▼ Synthesis of polysaccharide intercellular adhesin (PIA), accumulation associated protein (Aap) and extracellular matrix binding protein (Embp) are major mechanisms used by Staphylococcus epidermidisto evade immunity through biofilm formation. These evasion strategies are particularly suited for colonisation of medical devices such as heart valves, joint prostheses and central venous catheters resulting in significant patient morbidity. Two biological activities of PIA, Aap and Embp contribute to their role as an evasion molecules. Firstly their ‘barrier’ function limiting penetration of immune cells and antibiotics. Secondly, their ‘immunomodulatory’ properties which influence cytokine responses. At present little is known about these functional activities in physiological media and biological fluids. This thesis uses a cell biology approach to study the environment necessary for PLA production. Specifically in vitromodelling of biofilm formation, PIA production and S. epidermidisleukocyte co-culture experiments have been used to assess conditions that are conducive for PIA production. This thesis has identified that:• Specific cell culture media cause unique profiles of biofilm accumulation with differential production of PIA, Aap and Embp. • Fetal bovine serum and pooled human serum support S. epidermidisgrowth but differentially affect biofilm formation by PIA, Aap and Embp. • Large scale production of PIA (~20mg) can be achieved by culturing in Iscove's Modified Dulbecco's Media which has allowed streamlining of current isolation procedures. • PIA induction of cytokines, including IL-8 and TNF is dependent on being tethered to the bacterial membrane. • Macrophages can penetrate into a S. epidermidisproduced PIA ‘barrier’. • Immunosuppression of whole blood with dexamethasone unmasks the pathogenic advantage of PIA in S. epidermidis expressing PIA compared to negative controls. • Whole blood killing of S. epidermidisis dependent on CD1 lb/CD 18. • PIA induces whole blood killing dysfunction which is likely related to C5a production. • PIA can be produced in a whole blood environment.• Inocula of -1 0 colony forming unit of S. epidermidisare required to form biofilms in whole blood. This study suggests the importance of studying clinically important biofilm production mechanisms under conditions that closely resemble those in human disease.

Subjects/Keywords: 616.97; Staphylococcus infections; Immune system

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Al-Ishaq, R. J. (2013). Functional role of polysaccharide intercellular adhesin during Staphylococcus epidermidis biofilm interaction with the innate immune system. (Doctoral Dissertation). Swansea University. Retrieved from https://cronfa.swan.ac.uk/Record/cronfa42878 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.678490

Chicago Manual of Style (16^th Edition):

Al-Ishaq, Rand Jihad. “Functional role of polysaccharide intercellular adhesin during Staphylococcus epidermidis biofilm interaction with the innate immune system.” 2013. Doctoral Dissertation, Swansea University. Accessed August 24, 2019. https://cronfa.swan.ac.uk/Record/cronfa42878 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.678490.

MLA Handbook (7^th Edition):

Al-Ishaq, Rand Jihad. “Functional role of polysaccharide intercellular adhesin during Staphylococcus epidermidis biofilm interaction with the innate immune system.” 2013. Web. 24 Aug 2019.

Vancouver:

Al-Ishaq RJ. Functional role of polysaccharide intercellular adhesin during Staphylococcus epidermidis biofilm interaction with the innate immune system. [Internet] [Doctoral dissertation]. Swansea University; 2013. [cited 2019 Aug 24]. Available from: https://cronfa.swan.ac.uk/Record/cronfa42878 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.678490.

Council of Science Editors:

Al-Ishaq RJ. Functional role of polysaccharide intercellular adhesin during Staphylococcus epidermidis biofilm interaction with the innate immune system. [Doctoral Dissertation]. Swansea University; 2013. Available from: https://cronfa.swan.ac.uk/Record/cronfa42878 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.678490

13. Edenius, Maja Lena. Evolutionary conservation and characterization of the metazoan amino acid response.

Degree: 2018, MIT and Woods Hole Oceanographic Institution

URL: http://hdl.handle.net/1912/10215

► Signaling pathways that respond to stress and sense nutrient availability are highly conserved throughout eukaryotes. In mammalian cells, these pathways have evolved to regulate immune… (more)

Subjects/Keywords: Cells; Immune system; Amino acids

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Edenius, M. L. (2018). Evolutionary conservation and characterization of the metazoan amino acid response. (Thesis). MIT and Woods Hole Oceanographic Institution. Retrieved from http://hdl.handle.net/1912/10215

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Edenius, Maja Lena. “Evolutionary conservation and characterization of the metazoan amino acid response.” 2018. Thesis, MIT and Woods Hole Oceanographic Institution. Accessed August 24, 2019. http://hdl.handle.net/1912/10215.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Edenius, Maja Lena. “Evolutionary conservation and characterization of the metazoan amino acid response.” 2018. Web. 24 Aug 2019.

Vancouver:

Edenius ML. Evolutionary conservation and characterization of the metazoan amino acid response. [Internet] [Thesis]. MIT and Woods Hole Oceanographic Institution; 2018. [cited 2019 Aug 24]. Available from: http://hdl.handle.net/1912/10215.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Edenius ML. Evolutionary conservation and characterization of the metazoan amino acid response. [Thesis]. MIT and Woods Hole Oceanographic Institution; 2018. Available from: http://hdl.handle.net/1912/10215

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Aberdeen

14. McLean, Ryan. An investigation into the gliadin-specific immune response in schizophrenia.

Degree: PhD, 2018, University of Aberdeen

URL: http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=241481 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.774033

► A link between gluten consumption and the development of schizophrenia has been described in the literature. Furthermore increased levels of circulating antibodies directed against the… (more)

▼ A link between gluten consumption and the development of schizophrenia has been described in the literature. Furthermore increased levels of circulating antibodies directed against the gluten component, known as gliadin, have been observed in patients with schizophrenia. All studies reported to date measured antibodies against a mixture of native gliadin protein molecules, whereas dietary gliadin is partially digested, resulting in relatively long, indigestible, peptide fragments. In this study, levels of plasma antibodies against indigestible gliadin fragments were measured using an Enzyme-linked Immunosorbent Assay using a total of 405 archived plasma samples collected from patients with schizophrenia (n=169, 132 males and 37 females, aged 42.0 ± 13.3 years) and control subjects (n = 236, 159 males and 77 females, aged 44.7 ± 12.5 years). Patients were recruited from the North of Scotland in the period between 2003 and 2008 by NHS Grampian under Professor David St. Clair. Based on a genome-wide association study, 4 single nucleotide polymorphisms (SNPs) of interest were genotyped and their association with schizophrenia determined. Previously genotyped Human Leukocyte Antigen-DQ (HLA-DQ) variant data were also used to analyse HLA-DQ associations with plasma anti-gliadin antibody levels (AGA). Two cell-line based models were used to examine the effects of gliadin peptide incubation on cell maturation and/or differentiation of antigen presenting cells. The main finding of this thesis is that levels of plasma IgG against a γ-gliadin fragment, designated AAQ6C, are elevated in serum samples from patients with schizophrenia. Furthermore the gliadin-derived peptides were able to induce the maturation of a dendritic cell like model, albeit with a reduced pro-inflammatory phenotype. A link between HLA-DQ variants and AGA remains elusive, despite the associations described in this thesis. This thesis concludes that an immune response against AAQ6C is associated with schizophrenia. Although the mechanistic implications of this finding are unclear, it suggests that pathological contributions are unlikely to be mediated by cross-reactivity to proteins in the 4 central nervous system. The ability of the peptide antigens to induce the maturation of dendritic cells demonstrated that these peptides have immunogenic activity. The broader implications of this could be assessed with studies of the immunological response to gliadin peptides in the context of schizophrenia through the use of primary cell models.

Subjects/Keywords: Schizophrenia; Gluten; Neuroimmunology; Immune system

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

McLean, R. (2018). An investigation into the gliadin-specific immune response in schizophrenia. (Doctoral Dissertation). University of Aberdeen. Retrieved from http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=241481 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.774033

Chicago Manual of Style (16^th Edition):

McLean, Ryan. “An investigation into the gliadin-specific immune response in schizophrenia.” 2018. Doctoral Dissertation, University of Aberdeen. Accessed August 24, 2019. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=241481 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.774033.

MLA Handbook (7^th Edition):

McLean, Ryan. “An investigation into the gliadin-specific immune response in schizophrenia.” 2018. Web. 24 Aug 2019.

Vancouver:

McLean R. An investigation into the gliadin-specific immune response in schizophrenia. [Internet] [Doctoral dissertation]. University of Aberdeen; 2018. [cited 2019 Aug 24]. Available from: http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=241481 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.774033.

Council of Science Editors:

McLean R. An investigation into the gliadin-specific immune response in schizophrenia. [Doctoral Dissertation]. University of Aberdeen; 2018. Available from: http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=241481 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.774033

Queens University

15. Alotaibi, Faizah. An immune modulatory role for the fes proto-oncogene .

Degree: Pathology and Molecular Medicine, 2015, Queens University

URL: http://hdl.handle.net/1974/13420

► The Fes protein tyrosine kinase is abundantly expressed in phagocytic immune cells, including tumor associated macrophages. Fes knockout mice (fes-/-) display enhanced sensitivity to LPS,… (more)

Subjects/Keywords: fes oncogene; immune system

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Alotaibi, F. (2015). An immune modulatory role for the fes proto-oncogene . (Thesis). Queens University. Retrieved from http://hdl.handle.net/1974/13420

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Alotaibi, Faizah. “An immune modulatory role for the fes proto-oncogene .” 2015. Thesis, Queens University. Accessed August 24, 2019. http://hdl.handle.net/1974/13420.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Alotaibi, Faizah. “An immune modulatory role for the fes proto-oncogene .” 2015. Web. 24 Aug 2019.

Vancouver:

Alotaibi F. An immune modulatory role for the fes proto-oncogene . [Internet] [Thesis]. Queens University; 2015. [cited 2019 Aug 24]. Available from: http://hdl.handle.net/1974/13420.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Alotaibi F. An immune modulatory role for the fes proto-oncogene . [Thesis]. Queens University; 2015. Available from: http://hdl.handle.net/1974/13420

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universiteit Utrecht

16. Budding, K. Immune Evasion Strategies of Hepatitis C virus.

Degree: 2011, Universiteit Utrecht

URL: http://dspace.library.uu.nl:8080/handle/1874/194130

► In this thesis I will discuss the “tug of war” between hepatitis C virus (HCV) and our innate and adaptive immune system. A chronic HCV… (more)

Subjects/Keywords: HCV; immune evasion; adaptive immune system; innate immune system; viral infection; hepatitis c virus

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APA (6^th Edition):

Budding, K. (2011). Immune Evasion Strategies of Hepatitis C virus. (Masters Thesis). Universiteit Utrecht. Retrieved from http://dspace.library.uu.nl:8080/handle/1874/194130

Chicago Manual of Style (16^th Edition):

Budding, K. “Immune Evasion Strategies of Hepatitis C virus.” 2011. Masters Thesis, Universiteit Utrecht. Accessed August 24, 2019. http://dspace.library.uu.nl:8080/handle/1874/194130.

MLA Handbook (7^th Edition):

Budding, K. “Immune Evasion Strategies of Hepatitis C virus.” 2011. Web. 24 Aug 2019.

Vancouver:

Budding K. Immune Evasion Strategies of Hepatitis C virus. [Internet] [Masters thesis]. Universiteit Utrecht; 2011. [cited 2019 Aug 24]. Available from: http://dspace.library.uu.nl:8080/handle/1874/194130.

Council of Science Editors:

Budding K. Immune Evasion Strategies of Hepatitis C virus. [Masters Thesis]. Universiteit Utrecht; 2011. Available from: http://dspace.library.uu.nl:8080/handle/1874/194130

Columbia University

17. Thome, Joseph John-Charles. The effect of aging on human T cell subset compartmentalization and maintenance in tissue sites.

Degree: 2016, Columbia University

URL: https://doi.org/10.7916/D83F4PHZ

► Knowledge of human T cell responses and the pathways for their differentiation and maintenance from development into adulthood remains largely sparse. Much of what is… (more)

▼ Knowledge of human T cell responses and the pathways for their differentiation and maintenance from development into adulthood remains largely sparse. Much of what is known concerning the adaptive immune response in humans derives from analysis of peripheral blood, even though the majority of T cells within the body reside in tissue sites. We have established a protocol with LiveOnNY, the organ procurement organization of the New York metropolitan area allowing us access to healthy tissues from individual organ donors of a diverse background. Through novel analysis of lymphoid and mucosal tissues from infant and adult organ donors, we reveal how naïve, regulatory, and memory T cells dynamically populate and are maintained in tissues and circulation over the human lifespan. An initial multidimensional, quantitative analysis of human T cell compartmentalization involving 56 organ donors of a broad age range revealed that distribution of naïve, effector, and memory T cell subsets is largely dependent on tissue localization and differentiation state. Furthermore, T cell homeostasis driven by cytokine or TCR-mediated signals is dependent on CD4+or CD8+ T cell subset. Examining whether T cell subset distribution was set at birth, we compared T cell populations from a cohort of pediatric organ donors in the first two years of life to tissues from young adult donors aged 15-25 years. Results show a dynamic compartmentalization of naïve and regulatory T cells in all tissues early in life that is rapidly replaced with effector memory T cells (TEM) especially in mucosal sites further revealing the importance of a local adaptive immune response. Interestingly, the proportion and distribution of these T cell populations in tissue sites show varying levels of reliance on thymic output. Further evidence for the compartmentalization of the adaptive immune response and mechanisms for T cell maintenance throughout life can be shown through the analysis of T cell receptor sequences. We examined naïve and TEM populations in lymph nodes and spleen as a function of thymic output revealing low sharing of the naïve T cell repertoire between tissue sites with higher amounts of overlapping clones seen in TEM populations, especially with CD8+ T cells. These differences highlight potentially different roles for CD4+ and CD8+ T cells in the response to pathogen and their maintenance with age.

Subjects/Keywords: Immune system; T cells; Mucous membrane; Immune system – Physiology; Immune response; Immunology

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APA (6^th Edition):

Thome, J. J. (2016). The effect of aging on human T cell subset compartmentalization and maintenance in tissue sites. (Doctoral Dissertation). Columbia University. Retrieved from https://doi.org/10.7916/D83F4PHZ

Chicago Manual of Style (16^th Edition):

Thome, Joseph John-Charles. “The effect of aging on human T cell subset compartmentalization and maintenance in tissue sites.” 2016. Doctoral Dissertation, Columbia University. Accessed August 24, 2019. https://doi.org/10.7916/D83F4PHZ.

MLA Handbook (7^th Edition):

Thome, Joseph John-Charles. “The effect of aging on human T cell subset compartmentalization and maintenance in tissue sites.” 2016. Web. 24 Aug 2019.

Vancouver:

Thome JJ. The effect of aging on human T cell subset compartmentalization and maintenance in tissue sites. [Internet] [Doctoral dissertation]. Columbia University; 2016. [cited 2019 Aug 24]. Available from: https://doi.org/10.7916/D83F4PHZ.

Council of Science Editors:

Thome JJ. The effect of aging on human T cell subset compartmentalization and maintenance in tissue sites. [Doctoral Dissertation]. Columbia University; 2016. Available from: https://doi.org/10.7916/D83F4PHZ

Western Kentucky University

18. Scalf, Cassandra. Transcriptomic Response to Immune Challenge in Zebra Finch (Taeniopygia Guttata) Using RNA-SEQ.

Degree: MS, Department of Biology, 2018, Western Kentucky University

URL: https://digitalcommons.wku.edu/theses/2341

► Despite the convergence of rapid technological advances in genomics and the maturing field of ecoimmunology, our understanding of the genes that regulate immunity in… (more)

Subjects/Keywords: Immune system; innate immune response; lipopolysaccharide; Genetics and Genomics; Immunity; Ornithology

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APA (6^th Edition):

Scalf, C. (2018). Transcriptomic Response to Immune Challenge in Zebra Finch (Taeniopygia Guttata) Using RNA-SEQ. (Masters Thesis). Western Kentucky University. Retrieved from https://digitalcommons.wku.edu/theses/2341

Chicago Manual of Style (16^th Edition):

Scalf, Cassandra. “Transcriptomic Response to Immune Challenge in Zebra Finch (Taeniopygia Guttata) Using RNA-SEQ.” 2018. Masters Thesis, Western Kentucky University. Accessed August 24, 2019. https://digitalcommons.wku.edu/theses/2341.

MLA Handbook (7^th Edition):

Scalf, Cassandra. “Transcriptomic Response to Immune Challenge in Zebra Finch (Taeniopygia Guttata) Using RNA-SEQ.” 2018. Web. 24 Aug 2019.

Vancouver:

Scalf C. Transcriptomic Response to Immune Challenge in Zebra Finch (Taeniopygia Guttata) Using RNA-SEQ. [Internet] [Masters thesis]. Western Kentucky University; 2018. [cited 2019 Aug 24]. Available from: https://digitalcommons.wku.edu/theses/2341.

Council of Science Editors:

Scalf C. Transcriptomic Response to Immune Challenge in Zebra Finch (Taeniopygia Guttata) Using RNA-SEQ. [Masters Thesis]. Western Kentucky University; 2018. Available from: https://digitalcommons.wku.edu/theses/2341

University of Tasmania

19. Pankhurst, MW. Immune system modulation in the brain injury of the metallothionein-I/II null mutant mouse.

Degree: 2011, University of Tasmania

URL: https://eprints.utas.edu.au/11750/1/Pankhurst.pdf

► Metallothionein-I/II (MT-I/II) is a 6-7 kDa, cysteine rich, zinc and copper binding protein. MT-I/II null mutant ((^−/−)) mice have an altered response to brain injury.… (more)

▼ Metallothionein-I/II (MT-I/II) is a 6-7 kDa, cysteine rich, zinc and copper binding protein. MT-I/II null mutant ((^−/−)) mice have an altered response to brain injury. Therefore, MT-I/II has been proposed to be a protective protein after brain injury but the mechanism by which it confers protection remains elusive. There is a possibility that MT-I/II has protective actions within the injured brain but MT-I/II also has the capacity to modulate the immune system which plays a role in the progression of brain injury. The aim of this thesis is to investigate the differences in the progression of brain injury between wild type and MT-I/II(^−/−) mice with particular emphasis on the action of MT-I/II in organs peripheral to the central nervous system after brain injury. Using a cryolesion brain injury model, neuron death in MT-I/II(^−/−) mice was prolonged at later stages of the brain injury (7 days post-injury) meanwhile it had ceased in wild type mice. In conjunction with this occurrence, the numbers of T cells infiltrating the injury site were significantly higher in MT-I/II(^−/−) mice at 7 days post-injury. Chemokine mRNA synthesis was analysed to determine if MT-I/II(^−/−) mice had altered chemotactic signals that may affect the rate of T cell infiltration but differences were rarely observed when compared to wild type mice. In MT-I/II(^−/−) mice, circulating leukocytes showed no differences to wild type mice in the relative ratios of lymphocytes, neutrophils, monocytes or T cells. However, the absolute white blood cell count was significantly higher in the blood of MT-I/II(^−/−) mice, but only at 7 days post-injury. MT-I/II(^−/−) mice were also found to have lower levels of the marker of alternatively activated macrophages, Ym1, than wild type mice, both in macrophages in the brain and in monocytes in the blood after brain injury. Therefore, there appear to be several immune system differences between MT-I/II(^−/−) mice and wild type mice after brain injury. To further investigate the role of MT-I/II after brain injury, MT-I and MT-II mRNA levels were quantified by reverse transcriptase PCR. An enzyme-linked immunoassay (ELISA) was developed to measure MT-I/II protein levels in brain and liver after brain injury. Both MT-I and MT-II mRNA levels increase at 1 day post-injury in brain and liver and are decreased by 7 days post-injury. MT-I/II protein in brain was highest at 1 day post-injury but in the liver was maximally expressed at 7 days post injury. This increase in hepatic MT-I/II protein resulted in a higher hepatic zinc content in wild type mice compared to MT-I/II(^−/−) mice. Therefore these results suggest that brain injury induces a hepatic MT-I/II response which may be responsible for modulation of the essential trace metal, zinc after brain injury.

Subjects/Keywords: metallothionein; brain injury; inflammation; immune system

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APA (6^th Edition):

Pankhurst, M. (2011). Immune system modulation in the brain injury of the metallothionein-I/II null mutant mouse. (Thesis). University of Tasmania. Retrieved from https://eprints.utas.edu.au/11750/1/Pankhurst.pdf

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Pankhurst, MW. “Immune system modulation in the brain injury of the metallothionein-I/II null mutant mouse.” 2011. Thesis, University of Tasmania. Accessed August 24, 2019. https://eprints.utas.edu.au/11750/1/Pankhurst.pdf.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Pankhurst, MW. “Immune system modulation in the brain injury of the metallothionein-I/II null mutant mouse.” 2011. Web. 24 Aug 2019.

Vancouver:

Pankhurst M. Immune system modulation in the brain injury of the metallothionein-I/II null mutant mouse. [Internet] [Thesis]. University of Tasmania; 2011. [cited 2019 Aug 24]. Available from: https://eprints.utas.edu.au/11750/1/Pankhurst.pdf.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Pankhurst M. Immune system modulation in the brain injury of the metallothionein-I/II null mutant mouse. [Thesis]. University of Tasmania; 2011. Available from: https://eprints.utas.edu.au/11750/1/Pankhurst.pdf

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Aberdeen

20. Shewring, Dawn M. Fish antimicrobial peptides and the indentification of gadoid cathelicidins.

Degree: 2012, University of Aberdeen

URL: http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=185604 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.553865

► With the culture of marine fish species increasing, interest in ways to combat infection in these species has grown. One such avenue is the search… (more)

▼ With the culture of marine fish species increasing, interest in ways to combat infection in these species has grown. One such avenue is the search for novel antimicrobials. Antimicrobial peptides (AMPs) are host derived molecules with a significant role in innate immune responses and have been studied extensively in mammals. Well known AMP families include β-defensins, cathelicidins, liver expressed antimicrobial peptides and, specific to fish, the piscidins. While these molecules have been found in some fish species mining of expressed sequence tag (EST) databases was carried out to identify them in other fishes. In this study we have found new members of the β-defensin, cathelicidin and piscidin families of AMPs, while also identifying new hepcidins and LEAP-2 molecules in a diverse range of fish species. The rest of this thesis focused on one major AMP family, the cathelicidins, which in fish have been mainly identified in salmonids. They are stored in secondary granules of neutrophils as inactive pro-peptides and when infection occurs, a cleavage event releases the active mature form that effects microbicidal activity. Characterization of the cathelicidin genes present in Atlantic cod (Gadus morhua) and haddock (Melanogrammus aeglefinus) was undertaken. A number of ESTs with significant homology to cathelicidins were found in Atlantic cod. Primers were designed to amplify these sequences by PCR in both gadoid species, and the gene products were cloned and sequenced. One and two cathelicidin genes were identified in cod (gmCath1) and haddock (maCath1; maCath2), respectively, which differ in the length of their active mature peptides. Gadoid cathelicidins were constitutively expressed in many tissues and were upregulated by a range of immunostimulants. Analysis of the gmCath1 promoter revealed numerous putative transcription factor binding sites, some of which were used in an expression vector construct to show upregulation of gene expression when stimulated with the viral RNA mimic Poly I:C. Synthetic and recombinant gadoid cathelicidins were produced but did not appear to display antimicrobial activity, so this requires further investigation. The discovery of new members of the major AMP families in such a diverse range of fish species bodes well for future research into the use of these antimicrobials as potential disease control molecules in the aquaculture industry. Particularly for Atlantic cod this is crucial as the major cod farms in Norway are experiencing difficulties with bacterial infections for which there is no vaccine at present.

Subjects/Keywords: 571.9617; Salmonidae : Atlantic cod : Immune System

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Shewring, D. M. (2012). Fish antimicrobial peptides and the indentification of gadoid cathelicidins. (Doctoral Dissertation). University of Aberdeen. Retrieved from http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=185604 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.553865

Chicago Manual of Style (16^th Edition):

Shewring, Dawn M. “Fish antimicrobial peptides and the indentification of gadoid cathelicidins.” 2012. Doctoral Dissertation, University of Aberdeen. Accessed August 24, 2019. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=185604 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.553865.

MLA Handbook (7^th Edition):

Shewring, Dawn M. “Fish antimicrobial peptides and the indentification of gadoid cathelicidins.” 2012. Web. 24 Aug 2019.

Vancouver:

Shewring DM. Fish antimicrobial peptides and the indentification of gadoid cathelicidins. [Internet] [Doctoral dissertation]. University of Aberdeen; 2012. [cited 2019 Aug 24]. Available from: http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=185604 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.553865.

Council of Science Editors:

Shewring DM. Fish antimicrobial peptides and the indentification of gadoid cathelicidins. [Doctoral Dissertation]. University of Aberdeen; 2012. Available from: http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=185604 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.553865

21. Sivagnanavelmurugan, M. The effect of seaweed polysaccharides on immune activity and immune gene expression in shrimp penaeus monodon culture system;.

Degree: 2015, Manonmaniam Sundaranar University

URL: http://shodhganga.inflibnet.ac.in/handle/10603/38404

►

An initial investigation was carried out to extract the polysaccharides such as fucoidan sodium alginate and alginic acid from brown seaweed s wightii the physicochemical… (more)

Subjects/Keywords: culture system; immune gene; polysaccharides; shrimp penaeus

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APA (6^th Edition):

Sivagnanavelmurugan, M. (2015). The effect of seaweed polysaccharides on immune activity and immune gene expression in shrimp penaeus monodon culture system;. (Thesis). Manonmaniam Sundaranar University. Retrieved from http://shodhganga.inflibnet.ac.in/handle/10603/38404

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Sivagnanavelmurugan, M. “The effect of seaweed polysaccharides on immune activity and immune gene expression in shrimp penaeus monodon culture system;.” 2015. Thesis, Manonmaniam Sundaranar University. Accessed August 24, 2019. http://shodhganga.inflibnet.ac.in/handle/10603/38404.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Sivagnanavelmurugan, M. “The effect of seaweed polysaccharides on immune activity and immune gene expression in shrimp penaeus monodon culture system;.” 2015. Web. 24 Aug 2019.

Vancouver:

Sivagnanavelmurugan M. The effect of seaweed polysaccharides on immune activity and immune gene expression in shrimp penaeus monodon culture system;. [Internet] [Thesis]. Manonmaniam Sundaranar University; 2015. [cited 2019 Aug 24]. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/38404.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Sivagnanavelmurugan M. The effect of seaweed polysaccharides on immune activity and immune gene expression in shrimp penaeus monodon culture system;. [Thesis]. Manonmaniam Sundaranar University; 2015. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/38404

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Jawaharlal Nehru University

22. Mir Manzoor Ahmed. Costimulatory molecules mediated regulation of the activation and differentiation of antigen presenting cells; -.

Degree: Genetic Engineering and Biotechnology, 2009, Jawaharlal Nehru University

URL: http://shodhganga.inflibnet.ac.in/handle/10603/35698

None

Bibliography p.90-121

Advisors/Committee Members: Agrewala Javed N.

Subjects/Keywords: antigen; immune system

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APA (6^th Edition):

Ahmed, M. M. (2009). Costimulatory molecules mediated regulation of the activation and differentiation of antigen presenting cells; -. (Thesis). Jawaharlal Nehru University. Retrieved from http://shodhganga.inflibnet.ac.in/handle/10603/35698

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Ahmed, Mir Manzoor. “Costimulatory molecules mediated regulation of the activation and differentiation of antigen presenting cells; -.” 2009. Thesis, Jawaharlal Nehru University. Accessed August 24, 2019. http://shodhganga.inflibnet.ac.in/handle/10603/35698.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Ahmed, Mir Manzoor. “Costimulatory molecules mediated regulation of the activation and differentiation of antigen presenting cells; -.” 2009. Web. 24 Aug 2019.

Vancouver:

Ahmed MM. Costimulatory molecules mediated regulation of the activation and differentiation of antigen presenting cells; -. [Internet] [Thesis]. Jawaharlal Nehru University; 2009. [cited 2019 Aug 24]. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/35698.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Ahmed MM. Costimulatory molecules mediated regulation of the activation and differentiation of antigen presenting cells; -. [Thesis]. Jawaharlal Nehru University; 2009. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/35698

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

23. Χατζηβέης, Κωνσταντίνος. Μελέτη του ανοσοποιητικού συστήματος και των παραμέτρων του σε ογκολογικούς ασθενείς μετά τη χορήγηση ταξανών και πλατινούχων σκευασμάτων.

Degree: 2011, University of Patras; Πανεπιστήμιο Πατρών

URL: http://hdl.handle.net/10442/hedi/27111

►

Aim: The aim of the present study was to exam the role of Paclitaxel (Taxane)and Carboplatin in the parameters of the immune system in patients… (more)

▼

Aim: The aim of the present study was to exam the role of Paclitaxel (Taxane)and Carboplatin in the parameters of the immune system in patients with non-smallcelllung cancer and in patients with ovarian cancer before, during and afterchemotherapy treatment, and the effect of this combination in the overall survival ofthe patients.Methods: 24 patients with non-small-cell lung cancer (NSCLC) and 20patients with ovarian cancer (all in stage IIIb-IV) were treated with a combination ofpaclitaxel and carboplatin for six treatment cicles and they were separated into twogroups in terms of survival.GROUP A (n=15). Long survival (>12 months for NSCLC, >30 months for ovarianCa)GROUP B (n=29). Long survival (<12 months for NSCLC, <30 months for ovarianCa)At the same time we combined the relevant parameters (CD3, CD4, CD8, CD56,CD34, IL-3, IFN-γ) with the quality of life during treatment with chemotherapy. Theresults were analyzed using ANOVA system.Results: We observed a significant statistical difference between the values ofCD4 and CD4/CD8 after chemotherapy between group A and group B (p=0,001 andp=0,006). This means that the further increase of T-helper cells after chemotherapyhas a better prognosis concerning survival.209In addiction, statistically interesting, which we may call a prognostic factor, was thedifference in values of IFN-γ between individuals of groups and B before and afterchemotherapy (p=0,039 and p=0,027, respectively). Patients with high IL-3 had littlechance of toxicity.Conclusions: In the current study we tried to demonstrate the effects from theuse of the combination of carboplatin-paclitaxel in the whole population of Tcells/cytokines and the reaction of them in the quality of life.

Σκοπός: Ο σκοπός της παρούσας μελέτης ήταν να εξετάσει τον ρόλο τηςταξόλης (paclitaxel) και της καρβοπλατίνης σε σχέση με τις παραμέτρους τουανοσοποιητικού συστήματος σε ασθενείς πάσχοντες από μη μικροκυτταρικό καρκίνοτου πνεύμονα και από καρκίνο των ωοθηκών· πριν, κατά τη διάρκεια και μετά απόχημειοθεραπεία και η επίδραση που είχε ο ανωτέρω συνδυασμός φαρμάκων στηνσυνολική επιβίωση των ασθενών.Υλικό και Μέθοδος: Εξετάσθηκαν 24 ασθενείς με μη-μικροκυτταρικόκαρκίνο του πνεύμονα και 20 με καρκίνο των ωοθηκών (όλοι μεταστατικοί), όπουχωρίστηκαν σε δύο ομάδες με κριτήριο την επιβίωση και που εν συνεχεία τουςχορηγήθηκε συνδυασμός καρβοπλατίνης και ταξόλης για έξι θεραπευτικούς κύκλους.Ομάδα Α (n=15). Ασθενείς με καλή επιβίωση (>12 μήνες για μη-μικροκυτταρικόκαρκίνο του πνεύμονα, >30 μήνες για καρκίνο των ωοθηκών)Ομάδα Β (n=29). Ασθενείς με «φτωχή» επιβίωση (<12 μήνες για μη-μικροκυτταρικόκαρκίνο του πνεύμονα, <30 μήνες για καρκίνο των ωοθηκών)Την ίδια χρονική περίοδο εξετάσθηκαν οι λεμφοκυτταρικοί υποπληθυσμοί(CD3, CD4, CD8, CD56, CD34) καθώς και οι κυτταροκίνες ιντερλευκίνη-3 (IL-3)και ιντερφερόνη-γ (IFN-γ), σε σχέση με την ποιότητα ζωής και το προσδόκιμο208επιβίωσης κατά την διάρκεια της χημειοθεραπευτικής αγωγής. Η στατιστική ανάλυσητων αποτελεσμάτων έγινε με την μέθοδο ANOVA.Αποτελέσματα: Από την εξαγωγή των αποτελεσμάτων…

Subjects/Keywords: Carboplatin; Chemotherapy; Immune system; Paclitaxel; Survival

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APA (6^th Edition):

Χατζηβέης, . �. (2011). Μελέτη του ανοσοποιητικού συστήματος και των παραμέτρων του σε ογκολογικούς ασθενείς μετά τη χορήγηση ταξανών και πλατινούχων σκευασμάτων. (Thesis). University of Patras; Πανεπιστήμιο Πατρών. Retrieved from http://hdl.handle.net/10442/hedi/27111

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Χατζηβέης, Κωνσταντίνος. “Μελέτη του ανοσοποιητικού συστήματος και των παραμέτρων του σε ογκολογικούς ασθενείς μετά τη χορήγηση ταξανών και πλατινούχων σκευασμάτων.” 2011. Thesis, University of Patras; Πανεπιστήμιο Πατρών. Accessed August 24, 2019. http://hdl.handle.net/10442/hedi/27111.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Χατζηβέης, Κωνσταντίνος. “Μελέτη του ανοσοποιητικού συστήματος και των παραμέτρων του σε ογκολογικούς ασθενείς μετά τη χορήγηση ταξανών και πλατινούχων σκευασμάτων.” 2011. Web. 24 Aug 2019.

Vancouver:

Χατζηβέης �. Μελέτη του ανοσοποιητικού συστήματος και των παραμέτρων του σε ογκολογικούς ασθενείς μετά τη χορήγηση ταξανών και πλατινούχων σκευασμάτων. [Internet] [Thesis]. University of Patras; Πανεπιστήμιο Πατρών; 2011. [cited 2019 Aug 24]. Available from: http://hdl.handle.net/10442/hedi/27111.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Χατζηβέης �. Μελέτη του ανοσοποιητικού συστήματος και των παραμέτρων του σε ογκολογικούς ασθενείς μετά τη χορήγηση ταξανών και πλατινούχων σκευασμάτων. [Thesis]. University of Patras; Πανεπιστήμιο Πατρών; 2011. Available from: http://hdl.handle.net/10442/hedi/27111

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Pretoria

24. Wedi, Opope Oyaka. The assessment of T-cell subsets in response to treatment in patients with breast or oesophageal cancer.

Degree: MSc, Immunology, 2015, University of Pretoria

URL: http://hdl.handle.net/2263/45940

► Background: Cancer is a crippling disease affecting 32.6 million people globally. It is currently ranked as the leading cause of death worldwide, and is associated… (more)

▼ Background: Cancer is a crippling disease affecting 32.6 million people globally. It is currently ranked as the leading cause of death worldwide, and is associated with significant morbidity and mortality. Despite advances made in the prevention, detection and treatment of malignancy, there remains a dearth of accurate and feasible prognostic and predictive factors for use in the management of patients suffering from cancer in developing countries. It is widely recognized that the immune system plays a fundamental role in regulating the development and progression of malignancy. T-lymphocytes in particular have been categorized into T-cell populations which either promote (T regulatory cells) or prevent (CD4+ and CD8+ T-lymphocyte) cancer development and progression. Aim: The aim of this thesis was to evaluate whether the levels of the respective pro- (T regulatory) and anti- (CD4+ and CD8+ T-lymphocytes) cancer T-lymphocyte subsets before treatment, and alterations of these levels following conventional anticancer treatment (surgery, chemotherapy and radiotherapy) could be used as markers of prognosis in conjunction with other well known prognostic factors, or as predictors of short term (5-7 weeks post-treatment) survival. Methods: Blood samples were collected from 25 breast cancer, and 10 oesophageal cancer patients before antitumor treatment, at day 1 post-treatment and at 5-7 weeks post-treatment. The circulating concentrations and percentages of CD4+, CD8+ and T regulatory cells were determined from whole blood by flow cytometry. These levels were used to determine the CD4: CD8+ T-cell ratio, the CD4+ Treg: total CD4+ Treg ratio and the CD8+ Treg: total CD8+ Treg ratio. Results: Early (stage 1 and 2) HER-2/neu negative breast cancer was associated with a higher CD4+ (558 versus 133 cells/μl; P=0.05) and CD8+ T-cell count (198 versus 58 cells/μl; P=0.05) as compared to early HER-2/neu positive breast cancer. Breast cancer patients showed a significant decline in CD8+CD25+CD127+ Treg cell subsets (P=0.012) following antitumor treatment. However, oesophageal cancer patients showed an increasing trend in CD8+CD127+FoxP3+ Treg cells at day 1 post-treatment (P=0.045) and at 5-7 weeks posttreatment (P=0.044). Patients who demised displayed a significantly lower CD4+: CD8+ Tcell ratio (1.2 versus 2.2; P=0.044) before treatment, as well as a lower CD4+ (111 versus 390 cells/μl; P=0.0046) and CD8+ T-cell count (88 versus 160 cells/μl; P=0.058) at day 1 posttreatment, as compared to those who survived. While patients who survived displayed a higher CD8+ Treg: total CD8+ T-cell ratio (1.48 versus 0.53 P=0.0126) before treatment, and a higher CD4+CD25+CD127+ Treg cell level at day 1 post-treatment (9 versus 2 cells/μl; P=0.047), as compared to those who demised. Conclusion Taken together the findings of this thesis suggest that the CD4+ and CD8+ T-cell count and CD4:CD8 T-cell ratio may serve as predictors of short-term survival in the management of breast and oesophageal cancer. Furthermore,… Advisors/Committee Members: Mokoena, Thabo Mishack (advisor), Cockeran, Riana (coadvisor), Moodley, Vanessa (coadvisor).

Subjects/Keywords: UCTD; Cancer; Immune system; Breast cancer; Treatment

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Wedi, O. O. (2015). The assessment of T-cell subsets in response to treatment in patients with breast or oesophageal cancer. (Masters Thesis). University of Pretoria. Retrieved from http://hdl.handle.net/2263/45940

Chicago Manual of Style (16^th Edition):

Wedi, Opope Oyaka. “The assessment of T-cell subsets in response to treatment in patients with breast or oesophageal cancer.” 2015. Masters Thesis, University of Pretoria. Accessed August 24, 2019. http://hdl.handle.net/2263/45940.

MLA Handbook (7^th Edition):

Wedi, Opope Oyaka. “The assessment of T-cell subsets in response to treatment in patients with breast or oesophageal cancer.” 2015. Web. 24 Aug 2019.

Vancouver:

Wedi OO. The assessment of T-cell subsets in response to treatment in patients with breast or oesophageal cancer. [Internet] [Masters thesis]. University of Pretoria; 2015. [cited 2019 Aug 24]. Available from: http://hdl.handle.net/2263/45940.

Council of Science Editors:

Wedi OO. The assessment of T-cell subsets in response to treatment in patients with breast or oesophageal cancer. [Masters Thesis]. University of Pretoria; 2015. Available from: http://hdl.handle.net/2263/45940

University of Louisville

25. Mott, Meghan Carey. Cytokine genetics and expression : implications of an immunogenetic pathogenesis in autism spectrum disorders.

Degree: PhD, 2011, University of Louisville

URL: 10.18297/etd/1016 ; https://ir.library.louisville.edu/etd/1016

► Autism Spectrum Disorder (ASD) is an idiopathic pervasive neurodevelopmental disorder associated with various neuropathologies and immunological dysfunctions. Cytokines are regulatory proteins that facilitate communication between… (more)

▼ Autism Spectrum Disorder (ASD) is an idiopathic pervasive neurodevelopmental disorder associated with various neuropathologies and immunological dysfunctions. Cytokines are regulatory proteins that facilitate communication between the immune and central nervous systems and mediate inflammation, immunity, and hemopoiesis. Previous literature demonstrates that cytokine expression is altered systemically and in the central nervous system of individuals diagnosed with ASD when compared to matched neurotypical controls. Here it is proposed that cytokines are crucial mediators in autism pathogenesis. The central hypothesis of this research posits that an underlying genetic susceptibility in cytokine genes is triggered by environmental exigencies (e.g., stress, infection, ultrasound, hypoxia, pollutant or chemical exposure) during prenatal development. This hypothesis proposes that the convergence of these scenarios during vulnerable periods of neurodevelopment ultimately culminates in the autism phenotype. To test whether cytokines are crucial mediators in autism pathogenesis, the DNA sequences of 22 single nucleotide polymorphisms (SNPs) within 13 cytokine genes were genotyped in a cohort of autistic patients and controls. Three SNP frequencies for both pro-inflammatory [IL1R(+1970)] and anti-inflammatory [IL4(-590) and IL4(-33)] cytokine genes were found to be significantly associated with autism incidence. Next, cytokine mRNA profiles were investigated in post-mortem cortical tissue of eight autistic subjects and eight matched controls. Transcriptional profiling of cytokine genes in five post-mortem cortical regions corresponding to Brodmann Areas 4, 9, 17, 22 and 46 indicated heterogeneous expression of cytokine (TNF-a, IL-6, TGFß-l, IL-1ß) and chemokine (IL-8) transcripts in autistic subjects, but these alterations did not reach statistical significance or reflect values of cortical cytokine translational patterns established in previous literature. Finally, it was shown that systemic cytokine translational expression in the blood plasma of children diagnosed with autism disorder was not modulated with intravenous glutathione administration. These findings indicate that cytokines play an important role in ASD pathogenesis and reveal possible molecular mechanisms that warrant future investigation in etiological research. They also show that the antioxidant agent glutathione, which ostensibly alters cytokine expression at the intracellular level, does not affect systemic cytokine expression or ameliorate behavioral outcome when administered exogenously. Advisors/Committee Members: Casanova, Manuel F..

Subjects/Keywords: Autism; Cytokines; Immune system; Genetics; Glutathione; Inflammation

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Mott, M. C. (2011). Cytokine genetics and expression : implications of an immunogenetic pathogenesis in autism spectrum disorders. (Doctoral Dissertation). University of Louisville. Retrieved from 10.18297/etd/1016 ; https://ir.library.louisville.edu/etd/1016

Chicago Manual of Style (16^th Edition):

Mott, Meghan Carey. “Cytokine genetics and expression : implications of an immunogenetic pathogenesis in autism spectrum disorders.” 2011. Doctoral Dissertation, University of Louisville. Accessed August 24, 2019. 10.18297/etd/1016 ; https://ir.library.louisville.edu/etd/1016.

MLA Handbook (7^th Edition):

Mott, Meghan Carey. “Cytokine genetics and expression : implications of an immunogenetic pathogenesis in autism spectrum disorders.” 2011. Web. 24 Aug 2019.

Vancouver:

Mott MC. Cytokine genetics and expression : implications of an immunogenetic pathogenesis in autism spectrum disorders. [Internet] [Doctoral dissertation]. University of Louisville; 2011. [cited 2019 Aug 24]. Available from: 10.18297/etd/1016 ; https://ir.library.louisville.edu/etd/1016.

Council of Science Editors:

Mott MC. Cytokine genetics and expression : implications of an immunogenetic pathogenesis in autism spectrum disorders. [Doctoral Dissertation]. University of Louisville; 2011. Available from: 10.18297/etd/1016 ; https://ir.library.louisville.edu/etd/1016

University of Bath

26. Clay, Karina. Mechanisms underlying the role of sex hormones in the pathogenesis of rheumatoid arthritis.

Degree: PhD, 1993, University of Bath

URL: https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.358063

Subjects/Keywords: 572; Immune system

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Clay, K. (1993). Mechanisms underlying the role of sex hormones in the pathogenesis of rheumatoid arthritis. (Doctoral Dissertation). University of Bath. Retrieved from https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.358063

Chicago Manual of Style (16^th Edition):

Clay, Karina. “Mechanisms underlying the role of sex hormones in the pathogenesis of rheumatoid arthritis.” 1993. Doctoral Dissertation, University of Bath. Accessed August 24, 2019. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.358063.

MLA Handbook (7^th Edition):

Clay, Karina. “Mechanisms underlying the role of sex hormones in the pathogenesis of rheumatoid arthritis.” 1993. Web. 24 Aug 2019.

Vancouver:

Clay K. Mechanisms underlying the role of sex hormones in the pathogenesis of rheumatoid arthritis. [Internet] [Doctoral dissertation]. University of Bath; 1993. [cited 2019 Aug 24]. Available from: https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.358063.

Council of Science Editors:

Clay K. Mechanisms underlying the role of sex hormones in the pathogenesis of rheumatoid arthritis. [Doctoral Dissertation]. University of Bath; 1993. Available from: https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.358063

Drexel University

27. Egan, Kevin Pollard. Characterizing Herpes Simplex Virus Type 1 Replication Kinetics, Latency, and Reactivation in the Lip Scarification Model of Infection and Disease.

Degree: 2016, Drexel University

URL: http://hdl.handle.net/1860/idea:7172

►

Herpes simplex virus type 1 (HSV-1) is a common human pathogen which infects the majority of adults. The virus establishes a lifelong latent infection in… (more)

Subjects/Keywords: Microbiology; Immunology; Microbiological Phenomena; Immune System Phenomena

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Egan, K. P. (2016). Characterizing Herpes Simplex Virus Type 1 Replication Kinetics, Latency, and Reactivation in the Lip Scarification Model of Infection and Disease. (Thesis). Drexel University. Retrieved from http://hdl.handle.net/1860/idea:7172

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Egan, Kevin Pollard. “Characterizing Herpes Simplex Virus Type 1 Replication Kinetics, Latency, and Reactivation in the Lip Scarification Model of Infection and Disease.” 2016. Thesis, Drexel University. Accessed August 24, 2019. http://hdl.handle.net/1860/idea:7172.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Egan, Kevin Pollard. “Characterizing Herpes Simplex Virus Type 1 Replication Kinetics, Latency, and Reactivation in the Lip Scarification Model of Infection and Disease.” 2016. Web. 24 Aug 2019.

Vancouver:

Egan KP. Characterizing Herpes Simplex Virus Type 1 Replication Kinetics, Latency, and Reactivation in the Lip Scarification Model of Infection and Disease. [Internet] [Thesis]. Drexel University; 2016. [cited 2019 Aug 24]. Available from: http://hdl.handle.net/1860/idea:7172.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Egan KP. Characterizing Herpes Simplex Virus Type 1 Replication Kinetics, Latency, and Reactivation in the Lip Scarification Model of Infection and Disease. [Thesis]. Drexel University; 2016. Available from: http://hdl.handle.net/1860/idea:7172

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Drexel University

28. Lin, Selena. Analysis of the complexity of HBV-host junction sequences in patients with HBV-related hepatocellular carcinoma.

Degree: 2016, Drexel University

URL: http://hdl.handle.net/1860/idea:7162

►

Hepatocellular carcinoma (HCC) suffers from poor prognosis due to late detection and lack of effective therapies. Chronic hepatitis B virus (HBV) infection is the major… (more)

▼

Hepatocellular carcinoma (HCC) suffers from poor prognosis due to late detection and lack of effective therapies. Chronic hepatitis B virus (HBV) infection is the major etiology of HCC. Over 85% of HBV related HCCs contain integrated HBV DNA with various HBV-host junction sequences (HBV-JSs) generated by integration. We hypothesize that it is feasible to detect uncontrolled clonally-expanded (major) HBV-JSs or a reduced complexity of HBV-JSs in urine to investigate the dynamic of HBV-JSs during hepatocarcinogenesis and the detection of major HBV-JSs can be one approach to probe for HCC-driver mutations for HCC characterization. To test this hypothesis, three aims were proposed. Aim 1 is to develop an HBV-enriched next generation sequencing (NGS) assay for detecting cell-free HBV-JSs and was successfully completed. Aim 2 is to perform a meta-analysis of HBV-JSs for characterization of HCC. Using the developed assay from Aim 1, we identified 34 integration sites from 22 HCC tumor DNA. Together with previously reported sites, 1,554 sites were complied to investigate the associations of HCC-derived sites with clinical features to probe for potential HCC-drivers for HCC characterization. We found the most frequently identified site, TERT, was associated with old age (n=19) and cirrhosis (n=47), and integration in CCNE1 seems to be associated with non-cirrhotic HCCs, thus accomplishing Aim 2. Aim 3 is to analyze the complexity of HBV-JSs in the urine of HBV-HCC patients. Urine DNA from HBV-infected hepatitis (n=21), cirrhosis (n=19), and HCC (n=20) patients were analyzed and found that significantly more HCC urine samples contained detectable HBV-JSs compared to non-HCC urine samples (p < 0.0001), as well as an increase HBV-JS load (p < 0.0001). Although, the complexity of HBV-JSs in HCC urine samples was not significantly reduced as compared to non-HCC urine due to the small sample size. In conclusion, this study supports the hypothesis that HCC-derived clonally-expanded HBV-JSs and the complexity of HBV-JSs can be detected and analyzed in urine, Our study also supports that identification of major HBV-JSs can be one approach to detect HCC-drivers of hepatocarcinogenesis, and further our understanding of the role HBV integration plays in carcinogenesis.

Ph.D., Microbiology and Immunology – Drexel University, 2016

Advisors/Committee Members: Su, Ying-Hsiu, College of Medicine.

Subjects/Keywords: Microbiology; Immunology; Microbiological Phenomena; Immune System Phenomena

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Lin, S. (2016). Analysis of the complexity of HBV-host junction sequences in patients with HBV-related hepatocellular carcinoma. (Thesis). Drexel University. Retrieved from http://hdl.handle.net/1860/idea:7162

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Lin, Selena. “Analysis of the complexity of HBV-host junction sequences in patients with HBV-related hepatocellular carcinoma.” 2016. Thesis, Drexel University. Accessed August 24, 2019. http://hdl.handle.net/1860/idea:7162.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Lin, Selena. “Analysis of the complexity of HBV-host junction sequences in patients with HBV-related hepatocellular carcinoma.” 2016. Web. 24 Aug 2019.

Vancouver:

Lin S. Analysis of the complexity of HBV-host junction sequences in patients with HBV-related hepatocellular carcinoma. [Internet] [Thesis]. Drexel University; 2016. [cited 2019 Aug 24]. Available from: http://hdl.handle.net/1860/idea:7162.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Lin S. Analysis of the complexity of HBV-host junction sequences in patients with HBV-related hepatocellular carcinoma. [Thesis]. Drexel University; 2016. Available from: http://hdl.handle.net/1860/idea:7162

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Drexel University

29. Holmes, Andrew Patrick. Generation of Human Immunodeficiency Virus Type-1 Escape Mutants to Peptide Triazole Entry-Inhibiting Virus Inactivators.

Degree: 2016, Drexel University

URL: http://hdl.handle.net/1860/idea:7147

►

A study was performed to evolve resistant HIV-1 variants to multiple classes of peptide triazole entry inhibitors in order to understand the mechanisms of virus… (more)

▼

A study was performed to evolve resistant HIV-1 variants to multiple classes of peptide triazole entry inhibitors in order to understand the mechanisms of virus escape and inactivation. The macrocyclic and sulfhydryl-containing peptides used in this study are both capable of inactivating the virus through gp120 shedding, but the latter class has the additional ability to induce cell-free virolysis. Generation of HIV-1 escape mutants was accomplished through virus passaging on an immortalized T-cell line with dose escalation of inhibitor. Over the course of approximately four months, resistant virus cultures were established that grow under peptide concentrations that are two orders of magnitude greater than the starting concentration. Traditional Sanger sequencing of the escape mutant HIV-1 genome revealed similar escape profiles for both classes despite the difference between their inactivating effects. Mutations within the binding site and around the HIV-1 Env protein were discovered, including at the gp120-gp41 interface and the trimer apex, supporting the hypothesis that peptide triazoles actuate inactivating pressure throughout the protein complex. From this pool of mutations, individual and combinational mutations were generated in a pseudoviral system by site-directed mutagenesis to investigate the mechanism of escape. Small changes in the side chain at a pivotal location between the peptide binding cavities on gp120, V255I/T, were found to have a profound effect on inhibitor function. Flexible molecular docking of peptide triazoles onto HIV-1 Env trimers in the presence and absence of the V255 mutations suggests that the mutation fills an important binding cavity and prevents inhibitor penetration into the protein. The results of this work demonstrate that a major pathway of HIV-1 escape from peptide triazole virus inactivators occurs through binding site disruption, with other escape potential observed by alterations in Env gp120 shedding and infectivity.

Ph.D., Microbiology and Immunology – Drexel University, 2016

Advisors/Committee Members: Chaiken, Irwin M., College of Medicine.

Subjects/Keywords: Microbiology; Immunology; Microbiological Phenomena; Immune System Phenomena

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Holmes, A. P. (2016). Generation of Human Immunodeficiency Virus Type-1 Escape Mutants to Peptide Triazole Entry-Inhibiting Virus Inactivators. (Thesis). Drexel University. Retrieved from http://hdl.handle.net/1860/idea:7147

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Holmes, Andrew Patrick. “Generation of Human Immunodeficiency Virus Type-1 Escape Mutants to Peptide Triazole Entry-Inhibiting Virus Inactivators.” 2016. Thesis, Drexel University. Accessed August 24, 2019. http://hdl.handle.net/1860/idea:7147.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Holmes, Andrew Patrick. “Generation of Human Immunodeficiency Virus Type-1 Escape Mutants to Peptide Triazole Entry-Inhibiting Virus Inactivators.” 2016. Web. 24 Aug 2019.

Vancouver:

Holmes AP. Generation of Human Immunodeficiency Virus Type-1 Escape Mutants to Peptide Triazole Entry-Inhibiting Virus Inactivators. [Internet] [Thesis]. Drexel University; 2016. [cited 2019 Aug 24]. Available from: http://hdl.handle.net/1860/idea:7147.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Holmes AP. Generation of Human Immunodeficiency Virus Type-1 Escape Mutants to Peptide Triazole Entry-Inhibiting Virus Inactivators. [Thesis]. Drexel University; 2016. Available from: http://hdl.handle.net/1860/idea:7147

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Drexel University

30. Judy, Renae. Analysis of the Process of N-region addition in V(D)J Recombination through Diversity Identification of the CDR3 Region of B and T Cells.

Degree: 2013, Drexel University

URL: http://hdl.handle.net/1860/4241

►

A diverse and adaptable population of antigen receptors is an essential characteristic of a strong immune system. One way of generating this diversity is through… (more)

▼

A diverse and adaptable population of antigen receptors is an essential characteristic of a strong immune system. One way of generating this diversity is through V(D)J recombination which occurs in the third complimentary determining region (CDR3) of heavy chain antibodies presented by B and T cells. This process of diversification combines both germline encoded diversity through the recombination of 123 V genes, 27 D genes, 6 J genes, and non-germline encoded diversity. The later type of diversity is the result of terminal deoxynucleotidyl transferase (TdT) adding non-templated N-nucleotides. In this study I have created a set of computational tools to annotate the CDR3 for the most likely source of each nucleotide. After building these tools to identify palindromic (P) nucleotides and germline encoded elements, I sought to characterize the patterns of N-nucleotides in unique CDR3 sequences featuring a specific combinations of V, D, and J genes to determine the extent of non-templated diversity constraints. To do this, I quantified the amino acid distribution in both the V-D junction and the D-J junction and compared them against uniform distributions in B cells, in T cells, and in the out-of-frame distributions in B cells. This analysis revealed a significantly non-uniform distribution in all junction types. Comparisons between in frame and out-of-frame sequences also showed a significant difference in amino acid distribution. A pattern analysis of the N-regions lengths showed reading frame frequency peaks that conserve the D reading frame as recombinative joining is carried out. All of this suggests the non template regions are not fully randomized sources of diversity, rather they are used to generate a specific type of diversity while maintaining the amino acids of germline encoded elements. Further analysis of N-regions and their distributions under different environmental stresses, like illness, may give insight into the dynamic role of TdT and non templated V gene regions in a rapidly evolving environment.

M.S., Biomedical Engineering – Drexel University, 2013

Advisors/Committee Members: Hershberg, Uri.

Subjects/Keywords: Biomedical engineering; Immune system; Cell receptors

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Judy, R. (2013). Analysis of the Process of N-region addition in V(D)J Recombination through Diversity Identification of the CDR3 Region of B and T Cells. (Thesis). Drexel University. Retrieved from http://hdl.handle.net/1860/4241

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Judy, Renae. “Analysis of the Process of N-region addition in V(D)J Recombination through Diversity Identification of the CDR3 Region of B and T Cells.” 2013. Thesis, Drexel University. Accessed August 24, 2019. http://hdl.handle.net/1860/4241.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Judy, Renae. “Analysis of the Process of N-region addition in V(D)J Recombination through Diversity Identification of the CDR3 Region of B and T Cells.” 2013. Web. 24 Aug 2019.

Vancouver:

Judy R. Analysis of the Process of N-region addition in V(D)J Recombination through Diversity Identification of the CDR3 Region of B and T Cells. [Internet] [Thesis]. Drexel University; 2013. [cited 2019 Aug 24]. Available from: http://hdl.handle.net/1860/4241.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Judy R. Analysis of the Process of N-region addition in V(D)J Recombination through Diversity Identification of the CDR3 Region of B and T Cells. [Thesis]. Drexel University; 2013. Available from: http://hdl.handle.net/1860/4241

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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Open Access Theses and Dissertations