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1.
Glass, Ruth M., 1989-.
T-cell-mediated maternal immune activation during pregnancy: effect on cognitive function in offspring varying in genetic background.
Degree: PhD, Psychology, 2017, Rutgers University
URL: https://rucore.libraries.rutgers.edu/rutgers-lib/55480/
► Stimulation of the immune system during pregnancy, known as maternal immune activation (MIA), can cause long-lasting neurobiological and behavioral changes in the offspring. This phenomenon…
(more)
▼ Stimulation of the
immune system during pregnancy, known as maternal
immune activation (MIA), can cause long-lasting neurobiological and behavioral changes in the offspring. This phenomenon has been implicated in the etiology of developmental psychiatric disorders, such as autism and schizophrenia. Much of this evidence is predicated on animal models that rely on activation of the innate
immune system using bacterial agents such as LPS and/or viral mimics such Poly I:C, both of which act through toll-like receptors. Fewer studies have examined the role of direct activation of maternal T-cells during pregnancy and whether this also results in altered neurobiological and behavioral outcomes in offspring. Bacterial ‘superantigens’, such as Staphylococcal Enterotoxin A and B (SEA; SEB), are microbial proteins that activate CD4+ T-cells and cause prominent T-cell proliferation and cytokine production. We injected pregnant and non-pregnant adult female C57BL/6 and Balb/c mice with 5μg of SEA, SEB, or 0.9% saline, and measured splenic T-cell-derived cytokine concentrations (viz., IL-2, IFN-γ, IL-6, and IL-4) 2 hours later; animals injected with SEA were also measured for splenic concentrations of TNF-α and IL-17A. Half of the injected pregnant animals were brought to term, and their offspring were tested on a series of cognitive tasks starting at six weeks of age (postnatal day 42 [P42]). These tasks included a social interaction task, the elevated plus maze (EPM), an object recognition (OR) task, prepulse inhibition (PPI) of sensorimotor gating, and the Morris water maze (MWM). Results showed that SEA and SEB induced significant concentrations of all measured cytokines, and in particular IFN-γ, in both strains of pregnant mice when compared to controls. While C57BL/6 animals responded with significantly greater concentrations of most proinflammatory cytokines to SEA exposure, Balb/c mice had greater cytokine concentrations to SEB exposure. In addition, pregnant animals exhibited reduced production of proinflammatory cytokines, and in the case of Balb/c SEB-injected mice, increased anti-inflammatory cytokine IL-4. Behavioral results showed distinct phenotypes among offspring from SEA- or SEB-injected mothers. C57BL/6 offspring from SEA-injected mothers displayed decreases in social behavior and spatial learning, and increases in anxiety, locomotion, interest in a novel object, short-term spatial memory, and depressive-like behaviors. Balb/c offspring from SEB-injected mothers displayed decreases in spatial learning, and increases in social behavior, anxiety, sensorimotor gating abilities, and depressive like-behaviors. Overall, through the novel use of SEA and SEB as prenatal
immune challenges, we were able to elicit significant cytokine production in the mothers and distinct behavioral profiles in the offspring that both mirrors and diverges from previous models of maternal
immune activation in important ways. We conclude that T-cell-mediated maternal
immune activation is a valid and valuable model for studying the effects…
Advisors/Committee Members: Kusnecov, Alexander W (chair), Stromswold, Karin (internal member), Wagner, George (internal member), Tonelli, Leornardo (outside member), Tonelli, Leonardo (outside member), School of Graduate Studies.
Subjects/Keywords: Immune system
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APA (6th Edition):
Glass, Ruth M., 1. (2017). T-cell-mediated maternal immune activation during pregnancy: effect on cognitive function in offspring varying in genetic background. (Doctoral Dissertation). Rutgers University. Retrieved from https://rucore.libraries.rutgers.edu/rutgers-lib/55480/
Chicago Manual of Style (16th Edition):
Glass, Ruth M., 1989-. “T-cell-mediated maternal immune activation during pregnancy: effect on cognitive function in offspring varying in genetic background.” 2017. Doctoral Dissertation, Rutgers University. Accessed March 07, 2021.
https://rucore.libraries.rutgers.edu/rutgers-lib/55480/.
MLA Handbook (7th Edition):
Glass, Ruth M., 1989-. “T-cell-mediated maternal immune activation during pregnancy: effect on cognitive function in offspring varying in genetic background.” 2017. Web. 07 Mar 2021.
Vancouver:
Glass, Ruth M. 1. T-cell-mediated maternal immune activation during pregnancy: effect on cognitive function in offspring varying in genetic background. [Internet] [Doctoral dissertation]. Rutgers University; 2017. [cited 2021 Mar 07].
Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/55480/.
Council of Science Editors:
Glass, Ruth M. 1. T-cell-mediated maternal immune activation during pregnancy: effect on cognitive function in offspring varying in genetic background. [Doctoral Dissertation]. Rutgers University; 2017. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/55480/

McMaster University
2.
Quillier, Ophélie.
Proactive immunity: commensal bacteria interact with the immune system to fight Pseudomonas aeruginosa.
Degree: MSc, 2018, McMaster University
URL: http://hdl.handle.net/11375/23424
► Multi-drug resistant Pseudomonas aeruginosa has become an increasing threat. A threat compounded by the fact that the pipeline of antimicrobial discovery continues to lose effectiveness.…
(more)
▼ Multi-drug resistant Pseudomonas aeruginosa has become an increasing threat. A threat compounded by the fact that the pipeline of antimicrobial discovery continues to lose effectiveness. It is urgent that we identify new strategies to eliminate this and other multi-drug resistant pathogens. Meanwhile, we know that the resident bacteria of the respiratory tract interact with host cells to eliminate incoming threats.
The goal of this project is to understand the interactions at play in the microbiota of the respiratory tract and identify the specific commensal bacteria that inhibit P. aeruginosa in the presence of host cells.
Using a nasopharyngeal cell culture screen, we were able to identify several human commensals capable of inhibiting the growth of antibiotic-resistant P. aeruginosa in a host-dependent manner. It was also established that this phenotype can be reproduced in more complex systems, including a murine lung slice model, and that the elimination of the pathogen is dependent on the presence of living bacteria, mediated by a secreted factor.
We believe that the presence of these commensals has an immunomodulatory effect on the host. By characterizing the cytokines and chemokines produced by the host cells in response to the presence of these commensals, we have shown that these bacteria modify the immune response of the host to the pathogen.
Finally, having failed to develop a mouse model of infection, we have determined that the observed phenotype is not a direct action of the host cells, nor the result of hydrogen peroxide secretion. We have further characterized the bacterial strains using genome assembly.
This study has confirmed that commensal bacteria create a unique immune environment that contributes to the clearance of pathogens. Identifying bacteria and bacterial products capable of stimulating host defenses and modulating inflammation could provide a new therapeutic approach to reducing infection susceptibility in high-risk patients.
Thesis
Master of Science (MSc)
Antibiotics have for decades facilitated the cure of infections caused by pathogens of all kinds. Unfortunately, repeated exposure to antibiotics has rendered some pathogens highly resistant to traditional treatment. One notorious multi-drug resistant pathogen is Pseudomonas aeruginosa, now responsible for 10-15% of hospital-acquired respiratory infections. In this project we investigate the potential that lies in using commensal bacteria that exist in the microbiota of our respiratory tract to fight against pathogens that no longer respond to antibiotics. Stringent experiments with various models have revealed bacteria capable of killing Pseudomonas aeruginosa and helped us understand the mechanism of inhibition as well as the interactions of the bacteria with the immune system. Our results show that some bacteria of the microbiota are effective against Pseudomonas aeruginosa and that this line of study holds promise for the development of a new arsenal against a growing number of threatening pathogens.
Advisors/Committee Members: Surette, Michael, Biochemistry and Biomedical Sciences.
Subjects/Keywords: microbiome; immune system
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Quillier, O. (2018). Proactive immunity: commensal bacteria interact with the immune system to fight Pseudomonas aeruginosa. (Masters Thesis). McMaster University. Retrieved from http://hdl.handle.net/11375/23424
Chicago Manual of Style (16th Edition):
Quillier, Ophélie. “Proactive immunity: commensal bacteria interact with the immune system to fight Pseudomonas aeruginosa.” 2018. Masters Thesis, McMaster University. Accessed March 07, 2021.
http://hdl.handle.net/11375/23424.
MLA Handbook (7th Edition):
Quillier, Ophélie. “Proactive immunity: commensal bacteria interact with the immune system to fight Pseudomonas aeruginosa.” 2018. Web. 07 Mar 2021.
Vancouver:
Quillier O. Proactive immunity: commensal bacteria interact with the immune system to fight Pseudomonas aeruginosa. [Internet] [Masters thesis]. McMaster University; 2018. [cited 2021 Mar 07].
Available from: http://hdl.handle.net/11375/23424.
Council of Science Editors:
Quillier O. Proactive immunity: commensal bacteria interact with the immune system to fight Pseudomonas aeruginosa. [Masters Thesis]. McMaster University; 2018. Available from: http://hdl.handle.net/11375/23424

University of Western Ontario
3.
Caron, Christine.
Characterizing T Cell Phenotype In Patients With Hypersensitivity Reactions To Sulfamethoxazole And Beta-Lactam Antibiotics.
Degree: 2020, University of Western Ontario
URL: https://ir.lib.uwo.ca/etd/7278
► Delayed drug hypersensitivity reactions (DHRs) are idiosyncratic, T-cell mediated, and can present days after exposure to the culprit drug, resulting in varying degrees of skin…
(more)
▼ Delayed drug hypersensitivity reactions (DHRs) are idiosyncratic, T-cell mediated, and can present days after exposure to the culprit drug, resulting in varying degrees of skin rashes. We hypothesize that differences in activated peripheral T cell subsets and types of mediators released produce different clinical phenotypes of drug hypersensitivity reactions to sulphnamides and beta-lactam antibiotics.
We recruited participants with previous DHRs to sulfamethoxazole or beta-lactams . Peripheral blood mononuclear cells were isolated from participants. T-cell subset proliferation and activation was assessed by T-cell specific surface markers using 3H- thymidine incorporation and flow cytometry, and secreted cytokines were measured using bead-based detection.
There is insufficient evidence to conclude which T-cell subtypes are involved in different DHR clinical presentations. There were no significant differences between DHR participants and controls. More participants should be recruited to increase study power and range of clinical presentations, and consider alternate methods of identifying T-cells and modulators of interest.
Subjects/Keywords: Immune System Diseases
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
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APA (6th Edition):
Caron, C. (2020). Characterizing T Cell Phenotype In Patients With Hypersensitivity Reactions To Sulfamethoxazole And Beta-Lactam Antibiotics. (Thesis). University of Western Ontario. Retrieved from https://ir.lib.uwo.ca/etd/7278
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Caron, Christine. “Characterizing T Cell Phenotype In Patients With Hypersensitivity Reactions To Sulfamethoxazole And Beta-Lactam Antibiotics.” 2020. Thesis, University of Western Ontario. Accessed March 07, 2021.
https://ir.lib.uwo.ca/etd/7278.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Caron, Christine. “Characterizing T Cell Phenotype In Patients With Hypersensitivity Reactions To Sulfamethoxazole And Beta-Lactam Antibiotics.” 2020. Web. 07 Mar 2021.
Vancouver:
Caron C. Characterizing T Cell Phenotype In Patients With Hypersensitivity Reactions To Sulfamethoxazole And Beta-Lactam Antibiotics. [Internet] [Thesis]. University of Western Ontario; 2020. [cited 2021 Mar 07].
Available from: https://ir.lib.uwo.ca/etd/7278.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Caron C. Characterizing T Cell Phenotype In Patients With Hypersensitivity Reactions To Sulfamethoxazole And Beta-Lactam Antibiotics. [Thesis]. University of Western Ontario; 2020. Available from: https://ir.lib.uwo.ca/etd/7278
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
4.
阿部, 里見.
Alloreactivity and immunosuppressive properties of articular chondrocytes from osteoarthritic cartilage.
Degree: 博士(医学), 2016, Asahikawa Medical University / 旭川医科大学
URL: http://amcor.asahikawa-med.ac.jp/modules/xoonips/detail.php?id=20160630_O463
► PURPOSE:To determine whether articular chondrocytes derived from osteoarthritic knee joints could evoke alloreactive proliferation of peripheral blood mononuclear cells (PBMC) and inhibit mitogenic activity of…
(more)
▼ PURPOSE:To determine whether articular chondrocytes derived from osteoarthritic knee joints could evoke alloreactive proliferation of peripheral blood mononuclear cells (PBMC) and inhibit mitogenic activity of polyclonally activated CD4+ major histocompatibility complex (MHC) class II- restricted T cells in vitro.METHODS:Osteoarthritic cartilages of 17 patients aged 61 to 85 years were harvested during total knee arthroplasty. Chondrocytes were cultured for experiments. PBMCs, CD4+ T cells, CD8+ T cells, and CD14+ monocytes from healthy subjects were also used. To investigate the allogeneic response and immunosuppressive properties of chondrocytes, assays for one-way mixed lymphocyte reaction (MLR), apoptosis, activated CD4+ T-cell proliferation, and cytotoxic CD8+ T-cells were performed. Chondrocyte cell-surface antigens were examined using flow cytometry.RESULTS:Chondrocytes failed to trigger an allogeneic PBMC reaction and did not induce apoptosis of allogeneic PBMCs in the MLR assay. Chondrocytes inhibited the proliferation of polyclonally activated CD4+ T cells via cell-cell contact and escaped the allogeneic cytotoxic reactivity of CD8+ T cells. Chondrocytes expressed MHC class I but not MHC class II molecules or B7-1/-2-positive co-stimulatory molecules.CONCLUSION:Chondrocytes from osteoarthritic knees in older patients exhibited similar immunomodulatory properties in vitro to those in juveniles or adults.
Subjects/Keywords: chondrocytes; immune system; osteoarthritis
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
阿部, . (2016). Alloreactivity and immunosuppressive properties of articular chondrocytes from osteoarthritic cartilage. (Thesis). Asahikawa Medical University / 旭川医科大学. Retrieved from http://amcor.asahikawa-med.ac.jp/modules/xoonips/detail.php?id=20160630_O463
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
阿部, 里見. “Alloreactivity and immunosuppressive properties of articular chondrocytes from osteoarthritic cartilage.” 2016. Thesis, Asahikawa Medical University / 旭川医科大学. Accessed March 07, 2021.
http://amcor.asahikawa-med.ac.jp/modules/xoonips/detail.php?id=20160630_O463.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
阿部, 里見. “Alloreactivity and immunosuppressive properties of articular chondrocytes from osteoarthritic cartilage.” 2016. Web. 07 Mar 2021.
Vancouver:
阿部 . Alloreactivity and immunosuppressive properties of articular chondrocytes from osteoarthritic cartilage. [Internet] [Thesis]. Asahikawa Medical University / 旭川医科大学; 2016. [cited 2021 Mar 07].
Available from: http://amcor.asahikawa-med.ac.jp/modules/xoonips/detail.php?id=20160630_O463.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
阿部 . Alloreactivity and immunosuppressive properties of articular chondrocytes from osteoarthritic cartilage. [Thesis]. Asahikawa Medical University / 旭川医科大学; 2016. Available from: http://amcor.asahikawa-med.ac.jp/modules/xoonips/detail.php?id=20160630_O463
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
5.
Purushothaman, Divya.
Regulation of activated T cell death; -.
Degree: Chemical and Biotechnology, 2014, SASTRA University
URL: http://shodhganga.inflibnet.ac.in/handle/10603/22846
Abstract included
Reference p116-134, List of publications p114-115,
List of abbreviations p135-137, Summary included
Advisors/Committee Members: Sarin, Apurva.
Subjects/Keywords: Immune System; T cell death
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Purushothaman, D. (2014). Regulation of activated T cell death; -. (Thesis). SASTRA University. Retrieved from http://shodhganga.inflibnet.ac.in/handle/10603/22846
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Purushothaman, Divya. “Regulation of activated T cell death; -.” 2014. Thesis, SASTRA University. Accessed March 07, 2021.
http://shodhganga.inflibnet.ac.in/handle/10603/22846.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Purushothaman, Divya. “Regulation of activated T cell death; -.” 2014. Web. 07 Mar 2021.
Vancouver:
Purushothaman D. Regulation of activated T cell death; -. [Internet] [Thesis]. SASTRA University; 2014. [cited 2021 Mar 07].
Available from: http://shodhganga.inflibnet.ac.in/handle/10603/22846.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Purushothaman D. Regulation of activated T cell death; -. [Thesis]. SASTRA University; 2014. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/22846
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Queens University
6.
Alotaibi, Faizah.
An immune modulatory role for the fes proto-oncogene
.
Degree: Pathology and Molecular Medicine, 2015, Queens University
URL: http://hdl.handle.net/1974/13420
► The Fes protein tyrosine kinase is abundantly expressed in phagocytic immune cells, including tumor associated macrophages. Fes knockout mice (fes-/-) display enhanced sensitivity to LPS,…
(more)
▼ The Fes protein tyrosine kinase is abundantly expressed in phagocytic immune cells, including
tumor associated macrophages. Fes knockout mice (fes-/-) display enhanced sensitivity to LPS,
and this was shown to be associated with increased NF-κB signaling and TNFα production from
fes-/- macrophages. Interestingly, tumor onset in the mouse mammary tumor virus (MMTV-Neu)
transgenic mouse model of breast cancer is significantly delayed in fes-/- mice, and this was
associated with increased frequency of CD11b+ myeloid and CD3+ T cells in the premalignant
mammary glands. Recent studies have also implicated Fes in cross-talk between MHC-I and the
NF-κB and IRF-3 pathways in macrophages. Signal 3, the production of inflammatory cytokines
and Type I interferons downstream of NF-κB and IRF-3 pathways in antigen presenting cells, is
considered an important component of T-cell activation, after engagement of T cell receptor by
MHC presented antigen (Signal 1) and co-receptors by their ligands (Signal 2).
Using a lymphocytic choriomeningitis virus (LCMV) model of immune activation, I
show that LPS stimulated fes-/- macrophages promote more robust activation of LCMV antigenspecific
CD8+ T cells than wild type macrophages (fes+/+). Furthermore, LPS stimulated fes-/-
macrophages showed increased phosphorylation of NF-B and IRF-3. I also showed that Fes colocalizes
with MHC-I in dynamic vesicular structures within macrophages. These observations
are consistent with a model where Fes regulates Signal 3 in antigen presenting cells through roles
in cross-talk between MHC-I and the NF-kB and IRF-3 signaling pathways. This suggests that
Fes plays an immune checkpoint role at the level of Signal 3, and that Fes inhibition could
promote tumor immunity through increased Signal 3 driven T cell activation.
Subjects/Keywords: fes oncogene
;
immune system
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Alotaibi, F. (2015). An immune modulatory role for the fes proto-oncogene
. (Thesis). Queens University. Retrieved from http://hdl.handle.net/1974/13420
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Alotaibi, Faizah. “An immune modulatory role for the fes proto-oncogene
.” 2015. Thesis, Queens University. Accessed March 07, 2021.
http://hdl.handle.net/1974/13420.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Alotaibi, Faizah. “An immune modulatory role for the fes proto-oncogene
.” 2015. Web. 07 Mar 2021.
Vancouver:
Alotaibi F. An immune modulatory role for the fes proto-oncogene
. [Internet] [Thesis]. Queens University; 2015. [cited 2021 Mar 07].
Available from: http://hdl.handle.net/1974/13420.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Alotaibi F. An immune modulatory role for the fes proto-oncogene
. [Thesis]. Queens University; 2015. Available from: http://hdl.handle.net/1974/13420
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
7.
Edenius, Maja Lena.
Evolutionary conservation and characterization of the metazoan amino acid response.
Degree: 2018, MIT and Woods Hole Oceanographic Institution
URL: http://hdl.handle.net/1912/10215
► Signaling pathways that respond to stress and sense nutrient availability are highly conserved throughout eukaryotes. In mammalian cells, these pathways have evolved to regulate immune…
(more)
▼ Signaling pathways that respond to stress and sense nutrient availability are highly conserved throughout
eukaryotes. In mammalian cells, these pathways have evolved to regulate immune responses,
representing important therapeutic targets. Interestingly, components of these pathways can be found in
plants, yeast and nematodes, where they also participate in response to abiotic and biotic stress. The
Amino Acid Response (AAR) pathway, an ancient response to the cellular accumulation of uncharged
tRNA, is part of the larger Integrated Stress Response (ISR) in mammals. The ISR consists of multiple
branches, each one triggered by distinct stresses that produce phospho-eIF2α signal generation. Each ISR
initiating stress results in a unique cellular response due to activation of both the ISR and additional
parallel pathway(s) by the initiating stress, but, to date, no such alternate pathway has been identified for
the AAR pathway. Despite its integral role in stress adaptation, the ISR has not been studied in early
diverging animals. I have identified a highly conserved phosphorylation site in the protein eIF2α, the
signature ISR effector, which allowed me to use a mammalian antibody to identify and characterize the
ISR in the basal metazoan, Nematostella vectensis, revealing that the core components of the mammalian
ISR were present over 550 million years ago in the common ancestor of cnidarians and bilaterians.
Additionally, our lab has discovered a novel branch of the AAR pathway that regulates key tissue
protective signals. Using evolutionary conservation of this pathway in model organisms, I have identified
GCN1 as the branch point that links the signal generation components of the AAR pathway to
downstream therapeutic effects. I then used transcriptomic and protein interaction analyses to begin to
understand the scope of this pathway and identify key pathway regulators.
Subjects/Keywords: Cells; Immune system; Amino acids
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Edenius, M. L. (2018). Evolutionary conservation and characterization of the metazoan amino acid response. (Thesis). MIT and Woods Hole Oceanographic Institution. Retrieved from http://hdl.handle.net/1912/10215
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Edenius, Maja Lena. “Evolutionary conservation and characterization of the metazoan amino acid response.” 2018. Thesis, MIT and Woods Hole Oceanographic Institution. Accessed March 07, 2021.
http://hdl.handle.net/1912/10215.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Edenius, Maja Lena. “Evolutionary conservation and characterization of the metazoan amino acid response.” 2018. Web. 07 Mar 2021.
Vancouver:
Edenius ML. Evolutionary conservation and characterization of the metazoan amino acid response. [Internet] [Thesis]. MIT and Woods Hole Oceanographic Institution; 2018. [cited 2021 Mar 07].
Available from: http://hdl.handle.net/1912/10215.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Edenius ML. Evolutionary conservation and characterization of the metazoan amino acid response. [Thesis]. MIT and Woods Hole Oceanographic Institution; 2018. Available from: http://hdl.handle.net/1912/10215
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universidade Nova
8.
Lima, Jorge Natalino Ramos.
Immunomodulation in pregnancy and labor.
Degree: 2016, Universidade Nova
URL: http://www.rcaap.pt/detail.jsp?id=oai:run.unl.pt:10362/19609
► RESUMO: A gravidez é um desafio para o sistema imunológico, porque tem de tolerar um feto geneticamente diferente e ao mesmo tempo proteger tanto a…
(more)
▼ RESUMO: A gravidez é um desafio para o sistema imunológico, porque tem de tolerar um
feto geneticamente diferente e ao mesmo tempo proteger tanto a mãe como o feto
contra ameaças biológicas. Isto requer uma regulação estreita dos vários tipos de
células do sistema imunitário durante as diferentes fases da gravidez. Estudos
recentes revelaram que determinadas subpopulações de células B e células T têm
funções reguladoras e são essenciais para a manutenção da tolerância materno-fetal
durante as fases iniciais da gravidez. No entanto, não está claro se as células do
sistema imunológico materno, especialmente as recém descritas células reguladoras
B (Breg) e T (Treg), também podem desempenhar um papel relevante no final da
gravidez normal, no parto e no pós-parto.
Com o objetivo de analisar o perfil imunológico desde o final da gravidez até ao
pós-parto, foram efetuados três estudos observacionais que seguiram mulheres
saudáveis, grávidas (n = 43) e não grávidas (como grupo controlo; n = 35), vigiadas
na consulta externa do hospital CUF Descobertas. Em primeiro lugar, as contagens
no sangue periférico das subpopulações de linfócitos B, considerando o perfil
maturativo e incluindo as células Breg, foram analisadas em todas as mulheres
grávidas durante o terceiro trimestre da gravidez, no dia do parto (imediatamente
após o parto), e no pós-parto (pelo menos 6 semanas após o parto), e comparadas
com as do grupo de mulheres não grávidas. Em segundo lugar, a evolução das
subpopulações de células Treg foi avaliada no sangue periférico das mulheres
grávidas nos mesmos pontos temporais do estudo anterior, e comparadas com as do
grupo de controlo. Em terceiro lugar, o efeito do trabalho de parto sobre as
subpopulações circulantes de células T, e sobre as subpopulações de células Treg e
Breg, foi avaliado no dia do parto, comparando o subgrupo de mulheres grávidas que
tiveram o parto por cesariana eletiva (sem trabalho de parto; n = 14), com as que
tiveram um parto espontâneo vaginal (após o trabalho de parto; n = 18).
A quantificação e a caracterização fenotípica de células B e células T foi
efetuada por citometria de fluxo, de acordo com a expressão dos marcadores de
superfície celular presentes nas suas diferentes subpopulações. Especificamente, as subpopulações de células B foram caracterizadas no sangue periférico pela expressão
de CD19 (marcador de células B), e pela expressão de IgD e CD38 para identificar o
perfil maturativo dos linfócitos B de acordo com o sistema de classificação Bm1-5:
células B de transição, células B naïve, células B de memória não switched, células B
de memória switched entretanto divididas em células pós centro germinativo e
células de memória em repouso, e ainda plasmablastos. Os linfócitos Breg foram
caracterizados através da expressão de CD24, CD27, CD38, e a produção de IL-10
foi avaliada após a estimulação com acetato de forbolmiristato (PMA), ionóforo de
cálcio e lipopolissacárido (LPS) bacteriano. Relativamente às subpopulações de
células T de sangue periférico, as células com expressão de…
Advisors/Committee Members: Branco, Jorge da Cunha ;, Borrego, Luís Miguel Nabais.
Subjects/Keywords: Pregnancy; Immune system; Ciências Médicas
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MLA ·
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APA (6th Edition):
Lima, J. N. R. (2016). Immunomodulation in pregnancy and labor. (Thesis). Universidade Nova. Retrieved from http://www.rcaap.pt/detail.jsp?id=oai:run.unl.pt:10362/19609
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Lima, Jorge Natalino Ramos. “Immunomodulation in pregnancy and labor.” 2016. Thesis, Universidade Nova. Accessed March 07, 2021.
http://www.rcaap.pt/detail.jsp?id=oai:run.unl.pt:10362/19609.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Lima, Jorge Natalino Ramos. “Immunomodulation in pregnancy and labor.” 2016. Web. 07 Mar 2021.
Vancouver:
Lima JNR. Immunomodulation in pregnancy and labor. [Internet] [Thesis]. Universidade Nova; 2016. [cited 2021 Mar 07].
Available from: http://www.rcaap.pt/detail.jsp?id=oai:run.unl.pt:10362/19609.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Lima JNR. Immunomodulation in pregnancy and labor. [Thesis]. Universidade Nova; 2016. Available from: http://www.rcaap.pt/detail.jsp?id=oai:run.unl.pt:10362/19609
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Adelaide
9.
Nicotra, Lauren Louise.
Sex differences in allodynia: a complex interaction between 17beta-oestradiol and the innate immune system.
Degree: 2015, University of Adelaide
URL: http://hdl.handle.net/2440/98732
► Chronic pain is a debilitating and costly disease that is well known to preferentially affect women, particularly in their child bearing years. In spite of…
(more)
▼ Chronic pain is a debilitating and costly disease that is well known to preferentially affect women, particularly in their child bearing years. In spite of the obvious differences in pathophysiology between the sexes, the underlying mechanisms causing this sex difference in chronic pain have not yet been determined. Contributing to this gap in knowledge is the unrelenting use of preclinical animal pain models along with pain behavioural assessment techniques, which fail to best replicate the clinical pain experience. This translatability issue, along with the continued preferential use of male subjects in preclinical chronic pain investigations has meant that researchers have not yet uncovered what contributes to this sex difference in pain sensitivity, resulting in half the population (females) being inadequately treated for their pain. Among the numerous mechanisms that have been proposed to underlie this sex difference in chronic pain are both the gonadal hormones, particularly 17β-oestradiol, along with the innate
immune system. Although seperately known to play a role in chronic pain, prior to this PhD project, the relationship between these two systems had not be investigated in this debilitating condition. Recent evidence however has revealed not only the presence of oestrogen receptors on the key neuroimmune cells in pain responsive regions of the CNS, but also the exaggerated production of pain producing pro-inflammatory mediators in response to their activation. Given therefore that an association between these two pain-producing systems does exist, this PhD project investigated the relationship between 17β-oestradiol and the innate immue
system in exaggerated female chronic pain. Furthermore, based on the significant and reported translatability issues relating to preclinical pain studies in light of the currently available chronic pain experimental models and assessment techniques, this study further examined this relatinship for the first time using novel translatable preclinical methodologies. Through a series of key in vitro and in vivo studies our findings not only present and validate a novel preclinical chronic pain model and behavioural assessment technique that better produces and examines a preclincal neuropathy, but our findings also substantiate previous work demonstrating a significant role of 17β-oestradiol in chronic pain. Importantly this PhD project reveals for the first time not only the capability of the oestrogens to directly bind to key innate
immune signalling receptors involved in chronic pain, but that 17β-oestradiol priming of CNS innate
immune cells via such direct binding is in part responsible for the exaggerated female pain phenotype. Overall, the findings of this body of work highlight a fundamental difference in chronic pain pathophysiology between the sexes and further emphasize the importance of treating chronic pain in women during their reproductive years differently from prepubesent female, postmenopausal and male chronic pain sufferers.
Advisors/Committee Members: Hutchinson, Mark Rowland (advisor), Rolan, Paul Edward (advisor), School of Medicine (school).
Subjects/Keywords: allodynia; sex differences; immune system
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APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Nicotra, L. L. (2015). Sex differences in allodynia: a complex interaction between 17beta-oestradiol and the innate immune system. (Thesis). University of Adelaide. Retrieved from http://hdl.handle.net/2440/98732
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Nicotra, Lauren Louise. “Sex differences in allodynia: a complex interaction between 17beta-oestradiol and the innate immune system.” 2015. Thesis, University of Adelaide. Accessed March 07, 2021.
http://hdl.handle.net/2440/98732.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Nicotra, Lauren Louise. “Sex differences in allodynia: a complex interaction between 17beta-oestradiol and the innate immune system.” 2015. Web. 07 Mar 2021.
Vancouver:
Nicotra LL. Sex differences in allodynia: a complex interaction between 17beta-oestradiol and the innate immune system. [Internet] [Thesis]. University of Adelaide; 2015. [cited 2021 Mar 07].
Available from: http://hdl.handle.net/2440/98732.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Nicotra LL. Sex differences in allodynia: a complex interaction between 17beta-oestradiol and the innate immune system. [Thesis]. University of Adelaide; 2015. Available from: http://hdl.handle.net/2440/98732
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Gothenburg / Göteborgs Universitet
10.
Bennet, Sean.
Immunological and Microbiological perspectives on Irritable Bowel Syndrome.
Degree: 2017, University of Gothenburg / Göteborgs Universitet
URL: http://hdl.handle.net/2077/53610
► Abstract Irritable bowel syndrome affects ~11% of the population in the Western world and is characterised by altered bowel habits and abdominal pain. The range…
(more)
▼ Abstract
Irritable bowel syndrome affects ~11% of the population in the Western
world and is characterised by altered bowel habits and abdominal pain.
The range of additional symptoms between subjects makes groups of IBS
patients heterogeneous. Increased immune activity, altered gut microbiota
and diet are implicated in symptom generation though the mechanisms
are poorly understood. Moreover, gut microbiota and immune activity
interplay in relation to symptoms requires elucidation and while dietary
intervention is effective in some patients its impact on gut microbiota is
unclear. Most likely, all patients do not share the same symptom
generating mechanisms, and thus better means to stratify patients for both
research and treatment is required.
This thesis aimed to demonstrate how gut microbiota, the immune system
and their crosstalk result in symptom generation in IBS patients.
Furthermore, we aimed to demonstrate how dietary intervention affects
microbiota of the gut and if patient responsiveness to intervention therapy
could be predicted by gut microbiota profiles.
This thesis demonstrates that a diet low in poorly absorbed carbohydrates
(FODMAP) changes the gut microbiota composition and reduces
beneficial bacteria in IBS patients. Moreover, the composition of gut
microbiota can be used to discriminate patients whose IBS symptoms
improved or not after a low FODMAP diet. Additionally, serum or
mucosal cytokines cannot be used alone to diagnose IBS. However, a
subset of immuno-active patients had comparatively raised serum levels
of pro-inflammatory cytokines to healthy subjects and immuno-normal
IBS patients, although no major associations between cytokines and
symptoms were found. Further, IBS patients had an altered mucosal
expression of genes associated with an innate antimicrobial response
compared to healthy subjects. The antibacterial gene expression response
profiles as well as faecal and mucosal bacterial profiles were different
between immuno-active and immuno-normal IBS patients, but were not
associated to symptoms.
In conclusion, a subset of IBS patients has altered immune activity,
deemed by cytokine and innate antimicrobial response profiles, which do
not seem to be associated with any specific symptom profile. Further,
faecal microbial profiles may be used to identify responders to low
FODMAP diet therapy but negative impact of the diet on beneficial
bacteria requires further investigation. Thus, this thesis has identified
novel subgroups of IBS patients based on underlying mechanisms which
may guide development of innovative therapy options.
Subjects/Keywords: IBS; Microbiota; Immune system; FODMAPs
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APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Bennet, S. (2017). Immunological and Microbiological perspectives on Irritable Bowel Syndrome. (Thesis). University of Gothenburg / Göteborgs Universitet. Retrieved from http://hdl.handle.net/2077/53610
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Bennet, Sean. “Immunological and Microbiological perspectives on Irritable Bowel Syndrome.” 2017. Thesis, University of Gothenburg / Göteborgs Universitet. Accessed March 07, 2021.
http://hdl.handle.net/2077/53610.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Bennet, Sean. “Immunological and Microbiological perspectives on Irritable Bowel Syndrome.” 2017. Web. 07 Mar 2021.
Vancouver:
Bennet S. Immunological and Microbiological perspectives on Irritable Bowel Syndrome. [Internet] [Thesis]. University of Gothenburg / Göteborgs Universitet; 2017. [cited 2021 Mar 07].
Available from: http://hdl.handle.net/2077/53610.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Bennet S. Immunological and Microbiological perspectives on Irritable Bowel Syndrome. [Thesis]. University of Gothenburg / Göteborgs Universitet; 2017. Available from: http://hdl.handle.net/2077/53610
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Gothenburg / Göteborgs Universitet
11.
Svahn, Sara L.
Effects of dietary fatty acids on the immune system.
Degree: 2015, University of Gothenburg / Göteborgs Universitet
URL: http://hdl.handle.net/2077/39568
► Sepsis is a deadly disease with an increasing incidence worldwide. Today, antimicrobials are the only effective pharmacological treatment. At the same time, bacteria, the pathogens…
(more)
▼ Sepsis is a deadly disease with an increasing incidence worldwide. Today, antimicrobials are the only effective pharmacological treatment. At the same time, bacteria, the pathogens behind most cases of sepsis, are becoming more and more resistant to our available antibiotics. A considerable amount of time, effort and money has been spent into finding new drug-candidates for treating sepsis. To date, none has succeeded in clinical trials. Dietary fatty acids affect the immune system. Saturated fatty acids (SFAs) increase the risk for cardiovascular diseases and promote low-grade inflammation, whereas polyunsaturated fatty acids (PUFAs) are beneficial for patients with rheumatoid arthritis and atherosclerosis, being anti-inflammatory. In this thesis, we investigated the effects of dietary fatty acids on the immune system and survival in S. aureus-induced sepsis in mice.
Following 8 week of either low fat diet (LFD), high fat diet (HFD) rich in SFAs (HFD-S) or HFD rich in PUFAs (HFD-P) mice were inoculated with S. aureus to induce sepsis or investigated for mechanistic studies. Mice fed HFD-P had a better survival in sepsis and lower bacterial load compared with mice fed HFD-S. Further, we found an increased frequency of Ly6G+ neutrophils and CD117+ hematopoietic stem cells in the bone marrow in mice fed HFD-P at uninfected state. Moreover, neutrophils from mice fed HFD-P have an improved migratory capacity. Since dietary manipulations have an effect on the whole organism, we investigated the transcriptome profile in immunologically and metabolically important organs. Remarkably, the spleen showed a major response to HFD-P, i.e., down regulating both the innate and the adaptive immune system. We further investigated the mechanisms behind the increased frequency of neutrophils in mice fed HFD-P and showed an increased level of the major regulator of granulopoiesis, G-CSF, in the bone marrow. Additionally, there was an increased frequency of neutrophils in organs housing the marginated pool of neutrophils, i.e. spleen, liver and bone marrow. Since HFD-P contained different types of PUFAs, both omega-3 and omega-6 PUFAs (ω-3 PUFAs and ω-6 PUFAs), additional investigations aimed to determine which type of fatty acids mediated the beneficial effects. Omega-3 PUFAs were identified as the PUFAs responsible for the positive effects on the immune system and survival in septic infection.
In conclusion, our results show that, beyond their well-recognised anti-inflammatory properties, omega-3 PUFAs have immune-modulating properties, as they influence the transcriptome profile in the spleen, increase the frequency of neutrophils in bone marrow, spleen and liver, as well as, improve neutrophil function, making this type of PUFAs a potential supplementary treatment for sepsis.
Subjects/Keywords: dietary fatty acids; immune system
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Svahn, S. L. (2015). Effects of dietary fatty acids on the immune system. (Thesis). University of Gothenburg / Göteborgs Universitet. Retrieved from http://hdl.handle.net/2077/39568
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Svahn, Sara L. “Effects of dietary fatty acids on the immune system.” 2015. Thesis, University of Gothenburg / Göteborgs Universitet. Accessed March 07, 2021.
http://hdl.handle.net/2077/39568.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Svahn, Sara L. “Effects of dietary fatty acids on the immune system.” 2015. Web. 07 Mar 2021.
Vancouver:
Svahn SL. Effects of dietary fatty acids on the immune system. [Internet] [Thesis]. University of Gothenburg / Göteborgs Universitet; 2015. [cited 2021 Mar 07].
Available from: http://hdl.handle.net/2077/39568.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Svahn SL. Effects of dietary fatty acids on the immune system. [Thesis]. University of Gothenburg / Göteborgs Universitet; 2015. Available from: http://hdl.handle.net/2077/39568
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
12.
Hoption Cann, Stephen A.
The immune system and breast carcinoma : implications of dietary and other associated factors.
Degree: Department of Biology, 2018, University of Victoria
URL: https://dspace.library.uvic.ca//handle/1828/9538
► Introduction: A review of animal and human studies demonstrates that the immune system is a major factor in both the enhancement and inhibition of malignant…
(more)
▼ Introduction: A review of animal and human studies demonstrates that the
immune system is a major factor in both the enhancement and inhibition of malignant tumour growth. Macrophages, one of the most durable and versatile
immune cells, may be key to this
immune duality. Macrophages have been observed in particularly high concentrations in and around breast tumours. It has been suggested that these cells generally aid tumour growth, unless activated by an acute infections, immunomodulators or other means.
Study l: Using immunohistochemistry and computer-aided image analysis, macrophage concentrations in and around breast tumours were examined. Other pathological tissues were also examined for comparative purposes. Macrophage density was found to correlate positively with the Modified Bloom Richardson (MBR) grade (r = 0.41) and MBR subscore (r = 0.44), suggesting that macrophage concentrations increase as tumours become more aggressive. Similar infiltrations of macrophages were observed in lung, prostate and hyperplastic thyroid tissues; although in these latter tissues, macrophages were generally confined to the tumour periphery.
Study II: Iodine has been shown to play many roles in normal human physiology. In addition to its incorporation into thyroid hormones, iodine also has antibiotic and antitumour properties. Epidemiological studies of iodine in breast cancer have not been conducted. In this pilot case-control study, whole blood levels of 10 trace elements (Br, Cr, Fe, I, Mb, Mg, Mn, Se, V, and Zn) and their association with breast cancer was investigated. Other general, medical and dietary characteristics were examined as well. In comparison with iodine levels in Japan, iodine levels in the population under study were considerably lower, with a mean of 28.4 μg/l and a range of 19–35 μg/l. In the univariate logistic regression analysis, a number of significant associations with breast cancer were observed. A high education status (OR = 0.31) and high iron status (OR = 0.15) were associated with reduced risks, whereas previous hysterectomy or ovariectomy was associated with an increased risk of breast cancer (OR = 3.64). In the adjusted multivariate analysis, a high iron status remained associated with a reduced risk (OR = 0.01) and a history of breast pain with an increased risk (OR = 11.25).
Conclusion: Understanding the duality of
immune function, not only provides insight into cancer progression, but offers two primary avenues for treatment. First, one may down-regulate
immune reparative activities, which aid tumour growth. This may be accomplished by using immunosuppressants. A second approach is to take advantage of the large population of tumour-associated
immune cells, particularly macrophages, and stimulate these cells into their defensive activities. A wide variety of infectious agents may be used to stimulate this response. Finally, iodine is one immunomodulator that may be used to enhance
immune activity for treatment, or alternatively, prevent tumour growth through long-term intake;…
Advisors/Committee Members: Van Netten, Johannes Pieter (supervisor).
Subjects/Keywords: Breast carcinoma; Immune system; Dietary
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Hoption Cann, S. A. (2018). The immune system and breast carcinoma : implications of dietary and other associated factors. (Thesis). University of Victoria. Retrieved from https://dspace.library.uvic.ca//handle/1828/9538
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Hoption Cann, Stephen A. “The immune system and breast carcinoma : implications of dietary and other associated factors.” 2018. Thesis, University of Victoria. Accessed March 07, 2021.
https://dspace.library.uvic.ca//handle/1828/9538.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Hoption Cann, Stephen A. “The immune system and breast carcinoma : implications of dietary and other associated factors.” 2018. Web. 07 Mar 2021.
Vancouver:
Hoption Cann SA. The immune system and breast carcinoma : implications of dietary and other associated factors. [Internet] [Thesis]. University of Victoria; 2018. [cited 2021 Mar 07].
Available from: https://dspace.library.uvic.ca//handle/1828/9538.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Hoption Cann SA. The immune system and breast carcinoma : implications of dietary and other associated factors. [Thesis]. University of Victoria; 2018. Available from: https://dspace.library.uvic.ca//handle/1828/9538
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Melbourne
13.
Job, Emma R.
The role of soluble proteins of the innate immune system in host defence against influenza A viruses.
Degree: 2013, University of Melbourne
URL: http://hdl.handle.net/11343/38111
► Influenza A virus (IAV) contributes to significant morbidity and mortality in the human population. Soluble proteins of the innate immune system present in human and…
(more)
▼ Influenza A virus (IAV) contributes to significant morbidity and mortality in the human population. Soluble proteins of the innate immune system present in human and animal sera and airway secretions can mediate antiviral activity against IAV. Studies presented herein investigate the interactions of IAV and innate immune proteins with a particular emphasis on members the collectin superfamily, mannose binding lectin (MBL), surfactant protein (SP)-D and members of pentraxin superfamily including the short pentraxins, C-reactive protein (CRP) and serum amyloid P (SAP) and the long pentraxin, PTX3.
It is well recognized that collectins SP-D and MBL can mediate antiviral activity against IAV. As a mechanism to evade antibody (Ab)-mediated defences IAV acquires additional sites of N-linked glycans on the head of their hemagglutinin (HA), shielding and/or altering an antigenic site. Consistent with previous studies, this thesis has shown that the ability of the collectins SP-D and MBL to inhibit IAV is dependent upon the amount of N-linked glycans carried on the head of one of the major surface glycoproteins, the HA. This study demonstrated that the 2009 pandemic IAV strains (1 site of potential N-glycosylation; A(H1N1)pdm09) were resistant to the antiviral activities of SP-D and MBL. In contrast, seasonal IAV strains, which carry up to 4 N-glycosylation sites on the head of their HA, were sensitive to SP-D and MBL. Studies presented here have also examined glycosylation variants of A(H1N1)pdm09. Importantly, this thesis demonstrates that the addition of a glycan at Asn136 to A(H1N1)pdm09 HA allows escape from neutralizing Ab in vitro, but does not increase sensitivity to the collectins. Furthermore, variants expressing Asn136 were able to evade Ab responses to IAV vaccination in vivo. These studies highlight that a fine balance exists regarding the optimal pattern of HA glycosylation. A virulent/successful virus must have sufficient glycosylation to evade Ab-mediated immunity whilst still maintaining resistance to lectin-mediated defenses and appropriate receptor specificity to infect host cells.
The antimicrobial activity of CRP, SAP and PTX3 has been well studied, however little is known regarding their antiviral activities. Studies demonstrate a role for SAP and PTX3 against IAV, but not CRP. Previous studies by our group demonstrated that PTX3 expresses an α(2,3)-linked sialic acid (SAα(2,3)), that is recognized by the HA glycoprotein of certain IAV. Studies herein demonstrate that SAP acts in a similar manner to PTX3, however, presents an SAα(2,6) to the viral HA. We demonstrate that specificity of both the HA and the viral neuraminidase (NA) for particular SA linkages determines the susceptibility of H1N1 and H3N2 viruses to the antiviral activities of SAP and PTX3. Furthermore, we have selected virus mutants in the presence of human SAP or PTX3, and identified specific residues in or within the vicinity of the receptor-binding…
Subjects/Keywords: influenza; innate immune system
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Job, E. R. (2013). The role of soluble proteins of the innate immune system in host defence against influenza A viruses. (Doctoral Dissertation). University of Melbourne. Retrieved from http://hdl.handle.net/11343/38111
Chicago Manual of Style (16th Edition):
Job, Emma R. “The role of soluble proteins of the innate immune system in host defence against influenza A viruses.” 2013. Doctoral Dissertation, University of Melbourne. Accessed March 07, 2021.
http://hdl.handle.net/11343/38111.
MLA Handbook (7th Edition):
Job, Emma R. “The role of soluble proteins of the innate immune system in host defence against influenza A viruses.” 2013. Web. 07 Mar 2021.
Vancouver:
Job ER. The role of soluble proteins of the innate immune system in host defence against influenza A viruses. [Internet] [Doctoral dissertation]. University of Melbourne; 2013. [cited 2021 Mar 07].
Available from: http://hdl.handle.net/11343/38111.
Council of Science Editors:
Job ER. The role of soluble proteins of the innate immune system in host defence against influenza A viruses. [Doctoral Dissertation]. University of Melbourne; 2013. Available from: http://hdl.handle.net/11343/38111
14.
Al-Ishaq, Rand Jihad.
Functional role of polysaccharide intercellular adhesin during Staphylococcus epidermidis biofilm interaction with the innate immune system.
Degree: PhD, 2013, Swansea University
URL: https://cronfa.swan.ac.uk/Record/cronfa42878
;
https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.678490
► Synthesis of polysaccharide intercellular adhesin (PIA), accumulation associated protein (Aap) and extracellular matrix binding protein (Embp) are major mechanisms used by Staphylococcus epidermidisto evade immunity…
(more)
▼ Synthesis of polysaccharide intercellular adhesin (PIA), accumulation associated protein (Aap) and extracellular matrix binding protein (Embp) are major mechanisms used by Staphylococcus epidermidisto evade immunity through biofilm formation. These evasion strategies are particularly suited for colonisation of medical devices such as heart valves, joint prostheses and central venous catheters resulting in significant patient morbidity. Two biological activities of PIA, Aap and Embp contribute to their role as an evasion molecules. Firstly their ‘barrier’ function limiting penetration of immune cells and antibiotics. Secondly, their ‘immunomodulatory’ properties which influence cytokine responses. At present little is known about these functional activities in physiological media and biological fluids. This thesis uses a cell biology approach to study the environment necessary for PLA production. Specifically in vitromodelling of biofilm formation, PIA production and S. epidermidisleukocyte co-culture experiments have been used to assess conditions that are conducive for PIA production. This thesis has identified that:• Specific cell culture media cause unique profiles of biofilm accumulation with differential production of PIA, Aap and Embp. • Fetal bovine serum and pooled human serum support S. epidermidisgrowth but differentially affect biofilm formation by PIA, Aap and Embp. • Large scale production of PIA (~20mg) can be achieved by culturing in Iscove's Modified Dulbecco's Media which has allowed streamlining of current isolation procedures. • PIA induction of cytokines, including IL-8 and TNF is dependent on being tethered to the bacterial membrane. • Macrophages can penetrate into a S. epidermidisproduced PIA ‘barrier’. • Immunosuppression of whole blood with dexamethasone unmasks the pathogenic advantage of PIA in S. epidermidis expressing PIA compared to negative controls. • Whole blood killing of S. epidermidisis dependent on CD1 lb/CD 18. • PIA induces whole blood killing dysfunction which is likely related to C5a production. • PIA can be produced in a whole blood environment.• Inocula of -1 0 colony forming unit of S. epidermidisare required to form biofilms in whole blood. This study suggests the importance of studying clinically important biofilm production mechanisms under conditions that closely resemble those in human disease.
Subjects/Keywords: 616.97; Staphylococcus infections; Immune system
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Al-Ishaq, R. J. (2013). Functional role of polysaccharide intercellular adhesin during Staphylococcus epidermidis biofilm interaction with the innate immune system. (Doctoral Dissertation). Swansea University. Retrieved from https://cronfa.swan.ac.uk/Record/cronfa42878 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.678490
Chicago Manual of Style (16th Edition):
Al-Ishaq, Rand Jihad. “Functional role of polysaccharide intercellular adhesin during Staphylococcus epidermidis biofilm interaction with the innate immune system.” 2013. Doctoral Dissertation, Swansea University. Accessed March 07, 2021.
https://cronfa.swan.ac.uk/Record/cronfa42878 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.678490.
MLA Handbook (7th Edition):
Al-Ishaq, Rand Jihad. “Functional role of polysaccharide intercellular adhesin during Staphylococcus epidermidis biofilm interaction with the innate immune system.” 2013. Web. 07 Mar 2021.
Vancouver:
Al-Ishaq RJ. Functional role of polysaccharide intercellular adhesin during Staphylococcus epidermidis biofilm interaction with the innate immune system. [Internet] [Doctoral dissertation]. Swansea University; 2013. [cited 2021 Mar 07].
Available from: https://cronfa.swan.ac.uk/Record/cronfa42878 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.678490.
Council of Science Editors:
Al-Ishaq RJ. Functional role of polysaccharide intercellular adhesin during Staphylococcus epidermidis biofilm interaction with the innate immune system. [Doctoral Dissertation]. Swansea University; 2013. Available from: https://cronfa.swan.ac.uk/Record/cronfa42878 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.678490
15.
Sakelliou, Alexandra.
Μεταβολισμός και άσκηση.
Degree: 2017, National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ)
URL: http://hdl.handle.net/10442/hedi/39674
► We used thiol-based antioxidant supplementation (n-acetylcysteine, NAC) to determine whether immune mobilisation following skeletal muscle micro-trauma induced by exercise is redox-sensitive in healthy humans. According…
(more)
▼ We used thiol-based antioxidant supplementation (n-acetylcysteine, NAC) to determine whether immune mobilisation following skeletal muscle micro-trauma induced by exercise is redox-sensitive in healthy humans. According to a two-trial, double-blind, crossover, repeated measures design, 10 young men received either placebo or NAC (20 mg/kg/day) immediately after a muscle-damaging exercise protocol (300 eccentric contractions) and for eight consecutive days. Blood sampling and performance assessments were performed pre-exercise, post-exercise and daily throughout recovery. NAC reduced the decline of reduced glutathione in erythrocytes and the increase of plasma protein carbonyls, serum TAC and erythrocyte oxidized glutathione, TBARS and catalase activity during recovery thereby altering post-exercise redox status. The rise of muscle damage and inflammatory markers (muscle strength, creatine kinase activity, CRP, pro-inflammatory cytokines, adhesion molecules) was less pronounced in NAC during the first phase of recovery. The rise of leukocyte and neutrophil count was decreased by NAC post-exercise. Results on immune cell sub-populations obtained by flow cytometry indicated that NAC ingestion reduced the exercise-induced rise of total macrophages, HLA+ macrophages, and 11B+ macrophages and abolished the exercise-induced up-regulation of B lymphocytes. Natural killer cells declined only in PLA immediately post-exercise. These results indicate that thiol-based antioxidant supplementation blunts immune cell mobilisation in response to exercise-induced inflammation suggesting that leukocyte mobilization may be under redoxdependent regulation.
Η Ν ακετυλο-κυστείνη (NAC) είναι ένα αντιοξειδωτικό συμπλήρωμα που χρησιμοποιήθηκε για να διερευνήσει εάν η ενεργοποίηση του ανοσοποιητικού συστήματος που ακολουθεί τη φλεγμονή που επάγεται μέσω της άσκησης είναι οξειδοαναγωγικά εξαρτώμενη. Σε μια διασταυρούμενη, διπλή, τυφλή μελέτη επαναλαμβανόμενων μετρήσεων, 10 υγιείς άρρενες εθελοντές μετά το πέρας του πρωτόκολλου μυϊκής καταστροφής (300 έκκεντρες επαναλήψεις) έλαβαν N-ακετυλοκυστείνη (NAC) ή Placebo για οκτώ συνεχόμενες ημέρες. Οι μετρήσεις αίματος και μυϊκής απόδοσης πραγματοποιήθηκαν πριν την άσκηση, αμέσως μετά και καθημερινά κατά το στάδιο της ανάρρωσης. Η χορήγηση NAC στο στάδιο της ανάρρωσης ελάττωσε τη μείωση της γλουταθειόνης στα ερυθρά αιμοσφαίρια και την αύξηση στο πλάσμα των πρωτεινικών καρβονυλίων, της συνολικής αντιοξειδωτικής ικανότητας (TAC), της οξειδωμένης μορφής της γλουταθειόνης (GSSG), τις αντιδραστικές ουσίες του θεοβαρβιτουρικού οξέως (TBARS) και τη δραστικότητα της καταλάσης, μεταβάλλοντας έτσι την οξειδοαναγωγική κατάσταση. Επιπλέον, η χρήση της ΝAC μείωσε τη μυϊκή καταστροφή, την άνοδο των λευκών αιμοσφαιρίων και των ουδετερόφιλων, καθώς και των δεικτών φλεγμονής (μυϊκή δύναμη, κρεατινική κινάση, CRP, προ-φλεγμονώδεις κυτοκίνες, μόρια προσκόλλησης). Οι μετρήσεις των υποπληθυσμών του ανοσοποιητικού συστήματος, όπως καθορίστηκαν από την κυτταρομετρία ροής, απέδειξαν ότι η χορήγηση της NAC εξασθένησε…
Subjects/Keywords: Ανοσοποιητικό σύστημα; Immune system
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APA ·
Chicago ·
MLA ·
Vancouver ·
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Export
to Zotero / EndNote / Reference
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APA (6th Edition):
Sakelliou, A. (2017). Μεταβολισμός και άσκηση. (Thesis). National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ). Retrieved from http://hdl.handle.net/10442/hedi/39674
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Sakelliou, Alexandra. “Μεταβολισμός και άσκηση.” 2017. Thesis, National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ). Accessed March 07, 2021.
http://hdl.handle.net/10442/hedi/39674.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Sakelliou, Alexandra. “Μεταβολισμός και άσκηση.” 2017. Web. 07 Mar 2021.
Vancouver:
Sakelliou A. Μεταβολισμός και άσκηση. [Internet] [Thesis]. National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ); 2017. [cited 2021 Mar 07].
Available from: http://hdl.handle.net/10442/hedi/39674.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Sakelliou A. Μεταβολισμός και άσκηση. [Thesis]. National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ); 2017. Available from: http://hdl.handle.net/10442/hedi/39674
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universiteit Utrecht
16.
Budding, K.
Immune Evasion Strategies of Hepatitis C virus.
Degree: 2011, Universiteit Utrecht
URL: http://dspace.library.uu.nl:8080/handle/1874/194130
► In this thesis I will discuss the “tug of war” between hepatitis C virus (HCV) and our innate and adaptive immune system. A chronic HCV…
(more)
▼ In this thesis I will discuss the “tug of war” between hepatitis C virus (HCV) and our innate and adaptive
immune system. A chronic HCV infection is the leading causative agent for liver cirrhosis, and currently over 200 million people are infected worldwide. According to epidemiological studies, HCV infects around three till for million people per year. I will start with elaborating on the epidemiology and pathogenesis of the virus, followed by the viral characteristics of HCV, taxonomy, replication cycle, structure, and genome.
The focus of this paper will be on the aspect of viral persistence. In order to understand the
immune evasive strategies of HCV I have divided the immunological response in two different components, the innate and the adaptive component. I have tried to integrate the type of
immune response with the
immune evasion strategies of HCV. In the therapy section of the thesis I will elaborate on the currently used treatments, their mechanisms of action, the possible potential for vaccine development, and the reaction of the virus on the various therapeutic compounds.
With this thesis I have tried to give a coherent, comprehensive insight into the clinical relevance of an HCV infection, the viral characteristics, the
immune responses against HCV and HCVs strategies to evade these, and initiate a persistent infection.
Advisors/Committee Members: Van Baarle, D..
Subjects/Keywords: HCV; immune evasion; adaptive immune system; innate immune system; viral infection; hepatitis c virus
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MLA ·
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APA (6th Edition):
Budding, K. (2011). Immune Evasion Strategies of Hepatitis C virus. (Masters Thesis). Universiteit Utrecht. Retrieved from http://dspace.library.uu.nl:8080/handle/1874/194130
Chicago Manual of Style (16th Edition):
Budding, K. “Immune Evasion Strategies of Hepatitis C virus.” 2011. Masters Thesis, Universiteit Utrecht. Accessed March 07, 2021.
http://dspace.library.uu.nl:8080/handle/1874/194130.
MLA Handbook (7th Edition):
Budding, K. “Immune Evasion Strategies of Hepatitis C virus.” 2011. Web. 07 Mar 2021.
Vancouver:
Budding K. Immune Evasion Strategies of Hepatitis C virus. [Internet] [Masters thesis]. Universiteit Utrecht; 2011. [cited 2021 Mar 07].
Available from: http://dspace.library.uu.nl:8080/handle/1874/194130.
Council of Science Editors:
Budding K. Immune Evasion Strategies of Hepatitis C virus. [Masters Thesis]. Universiteit Utrecht; 2011. Available from: http://dspace.library.uu.nl:8080/handle/1874/194130

Columbia University
17.
Thome, Joseph John-Charles.
The effect of aging on human T cell subset compartmentalization and maintenance in tissue sites.
Degree: 2016, Columbia University
URL: https://doi.org/10.7916/D83F4PHZ
► Knowledge of human T cell responses and the pathways for their differentiation and maintenance from development into adulthood remains largely sparse. Much of what is…
(more)
▼ Knowledge of human T cell responses and the pathways for their differentiation and maintenance from development into adulthood remains largely sparse. Much of what is known concerning the adaptive immune response in humans derives from analysis of peripheral blood, even though the majority of T cells within the body reside in tissue sites. We have established a protocol with LiveOnNY, the organ procurement organization of the New York metropolitan area allowing us access to healthy tissues from individual organ donors of a diverse background. Through novel analysis of lymphoid and mucosal tissues from infant and adult organ donors, we reveal how naïve, regulatory, and memory T cells dynamically populate and are maintained in tissues and circulation over the human lifespan.
An initial multidimensional, quantitative analysis of human T cell compartmentalization involving 56 organ donors of a broad age range revealed that distribution of naïve, effector, and memory T cell subsets is largely dependent on tissue localization and differentiation state. Furthermore, T cell homeostasis driven by cytokine or TCR-mediated signals is dependent on CD4+or CD8+ T cell subset. Examining whether T cell subset distribution was set at birth, we compared T cell populations from a cohort of pediatric organ donors in the first two years of life to tissues from young adult donors aged 15-25 years. Results show a dynamic compartmentalization of naïve and regulatory T cells in all tissues early in life that is rapidly replaced with effector memory T cells (TEM) especially in mucosal sites further revealing the importance of a local adaptive immune response. Interestingly, the proportion and distribution of these T cell populations in tissue sites show varying levels of reliance on thymic output.
Further evidence for the compartmentalization of the adaptive immune response and mechanisms for T cell maintenance throughout life can be shown through the analysis of T cell receptor sequences. We examined naïve and TEM populations in lymph nodes and spleen as a function of thymic output revealing low sharing of the naïve T cell repertoire between tissue sites with higher amounts of overlapping clones seen in TEM populations, especially with CD8+ T cells. These differences highlight potentially different roles for CD4+ and CD8+ T cells in the response to pathogen and their maintenance with age.
Subjects/Keywords: Immune system; T cells; Mucous membrane; Immune system – Physiology; Immune response; Immunology
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APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Thome, J. J. (2016). The effect of aging on human T cell subset compartmentalization and maintenance in tissue sites. (Doctoral Dissertation). Columbia University. Retrieved from https://doi.org/10.7916/D83F4PHZ
Chicago Manual of Style (16th Edition):
Thome, Joseph John-Charles. “The effect of aging on human T cell subset compartmentalization and maintenance in tissue sites.” 2016. Doctoral Dissertation, Columbia University. Accessed March 07, 2021.
https://doi.org/10.7916/D83F4PHZ.
MLA Handbook (7th Edition):
Thome, Joseph John-Charles. “The effect of aging on human T cell subset compartmentalization and maintenance in tissue sites.” 2016. Web. 07 Mar 2021.
Vancouver:
Thome JJ. The effect of aging on human T cell subset compartmentalization and maintenance in tissue sites. [Internet] [Doctoral dissertation]. Columbia University; 2016. [cited 2021 Mar 07].
Available from: https://doi.org/10.7916/D83F4PHZ.
Council of Science Editors:
Thome JJ. The effect of aging on human T cell subset compartmentalization and maintenance in tissue sites. [Doctoral Dissertation]. Columbia University; 2016. Available from: https://doi.org/10.7916/D83F4PHZ

Western Kentucky University
18.
Scalf, Cassandra.
Transcriptomic Response to Immune Challenge in Zebra Finch (Taeniopygia Guttata) Using RNA-SEQ.
Degree: MS, Department of Biology, 2018, Western Kentucky University
URL: https://digitalcommons.wku.edu/theses/2341
► Despite the convergence of rapid technological advances in genomics and the maturing field of ecoimmunology, our understanding of the genes that regulate immunity in…
(more)
▼ Despite the convergence of rapid technological advances in genomics and the maturing field of ecoimmunology, our understanding of the genes that regulate immunity in wild populations is still nascent. Previous work to assess
immune function has relied upon relatively crude measures of immunocompetence. However, with next-generation RNA-sequencing, it is now possible to create a profile of gene expression in response to an
immune challenge. In this study, captive zebra finch (Taeniopygia guttata; adult males) were challenged with bacterial lipopolysaccharide (2 mg/Kg BW; dissolved in 0.9% saline) or vehicle (0.9% saline) to stimulate the
immune system. Two hours after injection, birds were euthanized and hypothalami, spleen, and red blood cells (RBCs) were collected. Taking advantage of the fully sequenced genome of zebra finch, total RNA was isolated, sequenced, and partially annotated in these tissue/cells. The data show 628 significantly upregulated transcripts in the hypothalamus, as well as 439 and 121 in the spleen and RBCs, respectively, relative to controls. Also, 134 transcripts in the hypothalamus, 517 in the spleen, and 61 in the RBCs were significantly downregulated. More specifically, a number of immunity-related transcripts (e.g., IL-1β, RSAD2, SOCS3) were upregulated among tissues/cells. Additionally, transcripts involved in metabolic processes (APOD, LRAT, RBP4) were downregulated, suggesting a potential trade-off in expression of genes that regulate immunity and metabolism. Unlike mammals, birds have nucleated RBCs, and these results suggest a novel transcriptomic response of RBCs to
immune challenge. Lastly, molecular biomarkers could be developed to rapidly screen bird populations by simple blood sampling in the field.
Advisors/Committee Members: Dr. Noah Ashley (Director), Dr. Claire Rinehart, and Dr. Cheryl Davis.
Subjects/Keywords: Immune system; innate immune response; lipopolysaccharide; Genetics and Genomics; Immunity; Ornithology
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Scalf, C. (2018). Transcriptomic Response to Immune Challenge in Zebra Finch (Taeniopygia Guttata) Using RNA-SEQ. (Masters Thesis). Western Kentucky University. Retrieved from https://digitalcommons.wku.edu/theses/2341
Chicago Manual of Style (16th Edition):
Scalf, Cassandra. “Transcriptomic Response to Immune Challenge in Zebra Finch (Taeniopygia Guttata) Using RNA-SEQ.” 2018. Masters Thesis, Western Kentucky University. Accessed March 07, 2021.
https://digitalcommons.wku.edu/theses/2341.
MLA Handbook (7th Edition):
Scalf, Cassandra. “Transcriptomic Response to Immune Challenge in Zebra Finch (Taeniopygia Guttata) Using RNA-SEQ.” 2018. Web. 07 Mar 2021.
Vancouver:
Scalf C. Transcriptomic Response to Immune Challenge in Zebra Finch (Taeniopygia Guttata) Using RNA-SEQ. [Internet] [Masters thesis]. Western Kentucky University; 2018. [cited 2021 Mar 07].
Available from: https://digitalcommons.wku.edu/theses/2341.
Council of Science Editors:
Scalf C. Transcriptomic Response to Immune Challenge in Zebra Finch (Taeniopygia Guttata) Using RNA-SEQ. [Masters Thesis]. Western Kentucky University; 2018. Available from: https://digitalcommons.wku.edu/theses/2341

Brunel University
19.
Taefehshokr, Nima.
Regulation of Egr2 expression in T cells and Egr2/3 function in tumour infiltrating T cells.
Degree: PhD, 2018, Brunel University
URL: http://bura.brunel.ac.uk/handle/2438/18863
;
https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.782712
► The immune system is an organism's defence to protect the body against invading pathogens. T cells are one of the major components and essential for…
(more)
▼ The immune system is an organism's defence to protect the body against invading pathogens. T cells are one of the major components and essential for immune responses. The early growth response gene (Egr2) in T cells is important for maintaining immune functions of T cells by promoting adaptive immune responses, while controlling inflammation and preventing the development of autoimmune diseases. A recent study by our group demonstrated the function of Egr2 as a checkpoint regulator controlling the proliferation and differentiation of the T cells. In association, Egr2 and 3 play an indispensable role in the T cell immune response, but its function in tumour regression is less well known. Also, the mechanism regulating Egr2 expression in T cells is still unclear. In this study, Egr2 was found to be significantly induced in tumour infiltrating lymphocytes (TILs) in a mouse melanoma tumour model. Deficiency of Egr2 and 3 resulted in rapid growth of tumour with impaired TIL expansion. The reduced expansion of TILs in Egr2/3 deficient mice were impaired in IL-2 production and expressed low levels of proliferation marker Ki-67, suggesting the positive role of Egr2 in CD8+ TIL expansion and tumour regression. Furthermore, Egr2 expression was regulated by antigens and cytokines including, IL-2, IL-4 and IFNγ, IL-6. The latter regulatory function was mediated by IFNγ/STAT1 and IL-6/STAT3 signalling pathways.
Subjects/Keywords: Immune system; CD8 TILs; T cells; Immune checkpoints
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Taefehshokr, N. (2018). Regulation of Egr2 expression in T cells and Egr2/3 function in tumour infiltrating T cells. (Doctoral Dissertation). Brunel University. Retrieved from http://bura.brunel.ac.uk/handle/2438/18863 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.782712
Chicago Manual of Style (16th Edition):
Taefehshokr, Nima. “Regulation of Egr2 expression in T cells and Egr2/3 function in tumour infiltrating T cells.” 2018. Doctoral Dissertation, Brunel University. Accessed March 07, 2021.
http://bura.brunel.ac.uk/handle/2438/18863 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.782712.
MLA Handbook (7th Edition):
Taefehshokr, Nima. “Regulation of Egr2 expression in T cells and Egr2/3 function in tumour infiltrating T cells.” 2018. Web. 07 Mar 2021.
Vancouver:
Taefehshokr N. Regulation of Egr2 expression in T cells and Egr2/3 function in tumour infiltrating T cells. [Internet] [Doctoral dissertation]. Brunel University; 2018. [cited 2021 Mar 07].
Available from: http://bura.brunel.ac.uk/handle/2438/18863 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.782712.
Council of Science Editors:
Taefehshokr N. Regulation of Egr2 expression in T cells and Egr2/3 function in tumour infiltrating T cells. [Doctoral Dissertation]. Brunel University; 2018. Available from: http://bura.brunel.ac.uk/handle/2438/18863 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.782712

University of Tasmania
20.
Pankhurst, MW.
Immune system modulation in the brain injury of the metallothionein-I/II null mutant mouse.
Degree: 2011, University of Tasmania
URL: https://eprints.utas.edu.au/11750/1/Pankhurst.pdf
► Metallothionein-I/II (MT-I/II) is a 6-7 kDa, cysteine rich, zinc and copper binding protein. MT-I/II null mutant ((−/−)) mice have an altered response to brain injury.…
(more)
▼ Metallothionein-I/II (MT-I/II) is a 6-7 kDa, cysteine rich, zinc and copper binding protein. MT-I/II null mutant ((−/−)) mice have an altered response to brain injury. Therefore, MT-I/II has been proposed to be a protective protein after brain injury but the mechanism by which it confers protection remains elusive. There is a possibility that MT-I/II has protective actions within the injured brain but MT-I/II also has the capacity to modulate the immune system which plays a role in the progression of brain injury. The aim of this thesis is to investigate the differences in the progression of brain injury between wild type and MT-I/II(−/−) mice with particular emphasis on the action of MT-I/II in organs peripheral to the central nervous system after brain injury. Using a cryolesion brain injury model, neuron death in MT-I/II(−/−) mice was prolonged at later stages of the brain injury (7 days post-injury) meanwhile it had ceased in wild type mice. In conjunction with this occurrence, the numbers of T cells infiltrating the injury site were significantly higher in MT-I/II(−/−) mice at 7 days post-injury. Chemokine mRNA synthesis was analysed to determine if MT-I/II(−/−) mice had altered chemotactic signals that may affect the rate of T cell infiltration but differences were rarely observed when compared to wild type mice. In MT-I/II(−/−) mice, circulating leukocytes showed no differences to wild type mice in the relative ratios of lymphocytes, neutrophils, monocytes or T cells. However, the absolute white blood cell count was significantly higher in the blood of MT-I/II(−/−) mice, but only at 7 days post-injury. MT-I/II(−/−) mice were also found to have lower levels of the marker of alternatively activated macrophages, Ym1, than wild type mice, both in macrophages in the brain and in monocytes in the blood after brain injury. Therefore, there appear to be several immune system differences between MT-I/II(−/−) mice and wild type mice after brain injury. To further investigate the role of MT-I/II after brain injury, MT-I and MT-II mRNA levels were quantified by reverse transcriptase PCR. An enzyme-linked immunoassay (ELISA) was developed to measure MT-I/II protein levels in brain and liver after brain injury. Both MT-I and MT-II mRNA levels increase at 1 day post-injury in brain and liver and are decreased by 7 days post-injury. MT-I/II protein in brain was highest at 1 day post-injury but in the liver was maximally expressed at 7 days post injury. This increase in hepatic MT-I/II protein resulted in a higher hepatic zinc content in wild type mice compared to MT-I/II(−/−) mice. Therefore these results suggest that brain injury induces a hepatic MT-I/II response which may be responsible for modulation of the essential trace metal, zinc after brain injury.
Subjects/Keywords: metallothionein; brain injury; inflammation; immune system
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Pankhurst, M. (2011). Immune system modulation in the brain injury of the metallothionein-I/II null mutant mouse. (Thesis). University of Tasmania. Retrieved from https://eprints.utas.edu.au/11750/1/Pankhurst.pdf
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Pankhurst, MW. “Immune system modulation in the brain injury of the metallothionein-I/II null mutant mouse.” 2011. Thesis, University of Tasmania. Accessed March 07, 2021.
https://eprints.utas.edu.au/11750/1/Pankhurst.pdf.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Pankhurst, MW. “Immune system modulation in the brain injury of the metallothionein-I/II null mutant mouse.” 2011. Web. 07 Mar 2021.
Vancouver:
Pankhurst M. Immune system modulation in the brain injury of the metallothionein-I/II null mutant mouse. [Internet] [Thesis]. University of Tasmania; 2011. [cited 2021 Mar 07].
Available from: https://eprints.utas.edu.au/11750/1/Pankhurst.pdf.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Pankhurst M. Immune system modulation in the brain injury of the metallothionein-I/II null mutant mouse. [Thesis]. University of Tasmania; 2011. Available from: https://eprints.utas.edu.au/11750/1/Pankhurst.pdf
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
21.
Sivagnanavelmurugan, M.
The effect of seaweed polysaccharides on immune activity
and immune gene expression in shrimp penaeus monodon culture
system;.
Degree: 2015, Manonmaniam Sundaranar University
URL: http://shodhganga.inflibnet.ac.in/handle/10603/38404
► An initial investigation was carried out to extract the polysaccharides such as fucoidan sodium alginate and alginic acid from brown seaweed s wightii the physicochemical…
(more)
▼ An initial investigation was carried out to extract
the polysaccharides such as fucoidan sodium alginate and alginic
acid from brown seaweed s wightii the physicochemical and
phytochemical characters of individual polysaccharides were studied
the result of uv spectral ft ir 13c and 1h nmr analysis indicated
the presence of carbon and anomeric proton of and#945; l fucose 1 6
and#946; d linked galacton and#946; d manuronic acid and sulphate
group in purified fucoidan and gluronic acid and mannuronic acid in
sodium alginate and alginic acid respectively the antibacterial
activity of all the three polysaccharides was screened against
vibrio pathogens the fucoidan sodium alginate powder sodium
alginate beads and alginic acid were enriched with artemia nauplii
at four different concentrations 100 200 300 and 400mg l for 12h
and were fed to p monodon postlarvae for 20 days and the growth
performance was studied then the p monodon postlarvae were
challenged with wssv and v parahaemolyticus individually and the
reduction in mortality percentage of experimental groups over
control group was recorded with good result in experimental groups
against both pathogens the wssv infection in the challenged shrimp
was determined through nested pcr analysis and confirmed the
concentration dependent variation heavy 910bp to low 296bp the v
parahaemolyticus load was increased from 10th to 30th days of
challenge test in control group however it was decreased positively
in the experimental groups further the polysaccharides were
supplemented individually
Advisors/Committee Members: Immanuel, G.
Subjects/Keywords: culture system; immune gene; polysaccharides; shrimp penaeus
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Sivagnanavelmurugan, M. (2015). The effect of seaweed polysaccharides on immune activity
and immune gene expression in shrimp penaeus monodon culture
system;. (Thesis). Manonmaniam Sundaranar University. Retrieved from http://shodhganga.inflibnet.ac.in/handle/10603/38404
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Sivagnanavelmurugan, M. “The effect of seaweed polysaccharides on immune activity
and immune gene expression in shrimp penaeus monodon culture
system;.” 2015. Thesis, Manonmaniam Sundaranar University. Accessed March 07, 2021.
http://shodhganga.inflibnet.ac.in/handle/10603/38404.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Sivagnanavelmurugan, M. “The effect of seaweed polysaccharides on immune activity
and immune gene expression in shrimp penaeus monodon culture
system;.” 2015. Web. 07 Mar 2021.
Vancouver:
Sivagnanavelmurugan M. The effect of seaweed polysaccharides on immune activity
and immune gene expression in shrimp penaeus monodon culture
system;. [Internet] [Thesis]. Manonmaniam Sundaranar University; 2015. [cited 2021 Mar 07].
Available from: http://shodhganga.inflibnet.ac.in/handle/10603/38404.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Sivagnanavelmurugan M. The effect of seaweed polysaccharides on immune activity
and immune gene expression in shrimp penaeus monodon culture
system;. [Thesis]. Manonmaniam Sundaranar University; 2015. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/38404
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Jawaharlal Nehru University
22.
Mir Manzoor Ahmed.
Costimulatory molecules mediated regulation of the
activation and differentiation of antigen presenting
cells; -.
Degree: Genetic Engineering and Biotechnology, 2009, Jawaharlal Nehru University
URL: http://shodhganga.inflibnet.ac.in/handle/10603/35698
Subjects/Keywords: antigen; immune system
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APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Ahmed, M. M. (2009). Costimulatory molecules mediated regulation of the
activation and differentiation of antigen presenting
cells; -. (Thesis). Jawaharlal Nehru University. Retrieved from http://shodhganga.inflibnet.ac.in/handle/10603/35698
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Ahmed, Mir Manzoor. “Costimulatory molecules mediated regulation of the
activation and differentiation of antigen presenting
cells; -.” 2009. Thesis, Jawaharlal Nehru University. Accessed March 07, 2021.
http://shodhganga.inflibnet.ac.in/handle/10603/35698.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Ahmed, Mir Manzoor. “Costimulatory molecules mediated regulation of the
activation and differentiation of antigen presenting
cells; -.” 2009. Web. 07 Mar 2021.
Vancouver:
Ahmed MM. Costimulatory molecules mediated regulation of the
activation and differentiation of antigen presenting
cells; -. [Internet] [Thesis]. Jawaharlal Nehru University; 2009. [cited 2021 Mar 07].
Available from: http://shodhganga.inflibnet.ac.in/handle/10603/35698.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Ahmed MM. Costimulatory molecules mediated regulation of the
activation and differentiation of antigen presenting
cells; -. [Thesis]. Jawaharlal Nehru University; 2009. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/35698
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Waterloo
23.
Christie, Darah.
Regulation of MH Class II Associated Invariant Chain in Oncorhynchus mykiss.
Degree: 2007, University of Waterloo
URL: http://hdl.handle.net/10012/3066
► Major histocompatibility complex (MHC) class II associated invariant chain is a chaperone of the mammalian MHC class II antigen presentation pathway. It is responsible for…
(more)
▼ Major histocompatibility complex (MHC) class II associated invariant chain is a chaperone of the mammalian MHC class II antigen presentation pathway. It is responsible for targeting the MHC class II dimer to the endocytic pathway, which allows for the loading of exogenous antigens onto the MHC class II receptor. Two genes showing significant sequence similarity to the mammalian invariant chain gene have been identified in rainbow trout. S25-7 and INVX are thought to play a role within the teleost MH class II antigen presentation pathway similar to that performed by the mammalian invariant chain. In vivo and in vitro methods have been used to investigate the regulation of these genes upon immune system activation. To induce an immune response both rainbow trout and the macrophage-like cell line RTS-11 were treated with phorbol myristate acetate (PMA). PMA is a stimulator of protein kinase C, which is involved in the activation of both B and T cells. After PMA treatment, individuals were sacrificed at several time points and tissues were collected for analysis. Up-regulation of IL-1β transcript, as detected by RT-PCR analysis, demonstrated the successful induction of an immune response in vivo. S25-7 transcript levels remained unchanged in gill, spleen, peripheral blood leukocytes and liver. However, the transcript was found to be significantly decreased in head kidney beginning 24 hours post-stimulation. INVX transcript levels remained unchanged in all tissues analyzed. In addition, the level of S25-7 transcript is higher in all tissues than INVX transcript.
Western blot analysis detected both S25-7 and INVX proteins within gill and spleen, indicating the presence of cell populations capable of presenting extracellular antigen within the MH class II dimer. Similar to transcript analysis, the level of invariant chain in these tissues remained unchanged during immune system activation. Neither INVX nor S25-7 was detected in head kidney, indicating this tissue may not function as a secondary immune tissue, as previously thought. Finally, western blot analysis failed to detect either INVX or S25-7 protein within liver, as expected in a non-immune tissue.
RTS11 analysis demonstrated a similar pattern of invariant chain expression in vitro. S25-7 transcript levels remained stable throughout the PMA stimulation time course, while INVX transcript was down-regulated at 48 and 96 hours post-stimulation, with a subsequent increase at 168 hours. However, both S25-7 and INVX protein levels remained unchanged during immune stimulation.
These results demonstrate a pattern of invariant chain tissue expression, providing information about the type of immune functions carried out at these sites. In addition, the results indicate that neither INVX nor S25-7 is up-regulated, at either the transcript or protein level upon immune system activation. This is in contrast to the mammalian invariant chain, which is up-regulated at both the transcript and protein level during an immune response, indicating that…
Subjects/Keywords: Immune System; Teleosts
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Christie, D. (2007). Regulation of MH Class II Associated Invariant Chain in Oncorhynchus mykiss. (Thesis). University of Waterloo. Retrieved from http://hdl.handle.net/10012/3066
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Christie, Darah. “Regulation of MH Class II Associated Invariant Chain in Oncorhynchus mykiss.” 2007. Thesis, University of Waterloo. Accessed March 07, 2021.
http://hdl.handle.net/10012/3066.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Christie, Darah. “Regulation of MH Class II Associated Invariant Chain in Oncorhynchus mykiss.” 2007. Web. 07 Mar 2021.
Vancouver:
Christie D. Regulation of MH Class II Associated Invariant Chain in Oncorhynchus mykiss. [Internet] [Thesis]. University of Waterloo; 2007. [cited 2021 Mar 07].
Available from: http://hdl.handle.net/10012/3066.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Christie D. Regulation of MH Class II Associated Invariant Chain in Oncorhynchus mykiss. [Thesis]. University of Waterloo; 2007. Available from: http://hdl.handle.net/10012/3066
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Johannesburg
24.
Ikapi, Thoty Moussotsi.
Immunotoxic and immunodisruptive effects of selected dense non-aqueous phase liquids in immunocompromised cells.
Degree: 2009, University of Johannesburg
URL: http://hdl.handle.net/10210/2356
► M.Sc.
Dense non-aqueous phase liquids (DNAPLs) are groups of chemicals often found beneath the water surface when chemical contamination of water occurs and they are…
(more)
▼ M.Sc.
Dense non-aqueous phase liquids (DNAPLs) are groups of chemicals often found beneath the water surface when chemical contamination of water occurs and they are called groundwater contaminants. Their improper storage and extensive use in industries as well as their slow degradation provide a long term source for of low level contamination of ground- and river water. Evidence from both human and animal studies suggests that volatile organic and organochlorinated compounds (specific types of DNAPLs), may increase host susceptibility to microbial infection, induce alterations in the maturation of effector immune cells and compromise immune surveillance mechanisms. These effects of DNAPLs hold special relevance for people living with HIV/AIDS. In light of this, the present study investigated the in vitro immunological effects of the two most common DNAPLs contaminants, Trichloroethylene (TCE) and Aroclor-1254 (ARO) in peripheral blood mononuclear cells (PBMCs) of immunocompromised and healthy donors. TCE and ARO were successfully dissolved in cell culture medium and added to freshly isolated PBMCs in a 1:1 ratio. Following incubation, cell functionality and cytotoxicity (or immunotoxicity) were assessed using MTT and LDH. Viability was confirmed and/or cell death analyzed by flow cytometry. Culture supernatants were used to assess NO and cytokine production as well as for quantification of viral replication. TCE and ARO induced a significant (p<0.05) decrease in cell viability/functionality in a dose-dependent manner. Flow cytometric analysis of cell death pathways indicated that TCE and ARO induced apoptosis. These chemicals also induced the secretion of both NO and proinflammatory cytokines suggesting that they may induce apoptosis via an inflammatory pathway, which may explain the mitochondrial dysfunction as determined by the MTT assay. ARO effects were more prominent than those of TCE, and both were more detrimental to HIV positive PBMCs compared to uninfected cells. The viral p24 levels increased in a dose-dependent fashion suggesting an effect for TCE and ARO on viral replication. This research concludes that DNAPL-contamination is detrimental to especially immuno-compromised systems.
Subjects/Keywords: Nonaqueous phase liquids; Immune system; Cell physiology
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Ikapi, T. M. (2009). Immunotoxic and immunodisruptive effects of selected dense non-aqueous phase liquids in immunocompromised cells. (Thesis). University of Johannesburg. Retrieved from http://hdl.handle.net/10210/2356
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Ikapi, Thoty Moussotsi. “Immunotoxic and immunodisruptive effects of selected dense non-aqueous phase liquids in immunocompromised cells.” 2009. Thesis, University of Johannesburg. Accessed March 07, 2021.
http://hdl.handle.net/10210/2356.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Ikapi, Thoty Moussotsi. “Immunotoxic and immunodisruptive effects of selected dense non-aqueous phase liquids in immunocompromised cells.” 2009. Web. 07 Mar 2021.
Vancouver:
Ikapi TM. Immunotoxic and immunodisruptive effects of selected dense non-aqueous phase liquids in immunocompromised cells. [Internet] [Thesis]. University of Johannesburg; 2009. [cited 2021 Mar 07].
Available from: http://hdl.handle.net/10210/2356.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Ikapi TM. Immunotoxic and immunodisruptive effects of selected dense non-aqueous phase liquids in immunocompromised cells. [Thesis]. University of Johannesburg; 2009. Available from: http://hdl.handle.net/10210/2356
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Boston University
25.
Fayngersh, Roman.
Role of obesity in modulating the immune system.
Degree: MS, Medical Sciences, 2014, Boston University
URL: http://hdl.handle.net/2144/15342
► INTRODUCTION: Diet induced obesity (DIO) is a major driving force responsible for low-grade inflammation mediated immune system decline. Impaired immune defenses lead to a number…
(more)
▼ INTRODUCTION: Diet induced obesity (DIO) is a major driving force responsible for low-grade inflammation mediated immune system decline. Impaired immune defenses lead to a number of chronic diseases and ultimately to an increased mortality.
DISCUSSION: Over half a billion people worldwide are considered overweight or obese. It has been estimated that $190 billion dollars was spent in the US on obesity-related healthcare costs just in 2005. Lower productivity, lost wages, higher insurance costs, and an increased strain on the healthcare system as a whole, are the hallmarks of the obesity epidemic. Considerable body of epidemiologic evidence implicates DIO as the major cause of numerous pathologies. The obese population doesn't just suffer increased mortality from chronic conditions such as, cardiovascular disease, pulmonary diseases, Type 2 diabetes, various cancers, hyperlipidemia, hypertension, non-alcoholic fatty liver disease (NAFLD), renal failure, osteoarthritis and many other slow-onset diseases. Obese individuals also have increased mortality for more acute conditions such as N1H1 influenza virus, allergic diseases, and post-surgical complications while also lowering the efficacy for vaccinations and Helicobacter pylori eradication therapies. Today scientists recognize adipose tissue as the largest endocrine organ in the human body, releasing a myriad of paracrine and endocrine molecular factors. During DIO these adipocytokines induce a proinflammatory switch in the adipose tissue machinery, initiating chronic low-grade inflammation. Sensing an ongoing attack the immune system responds trying to maintain homeostasis. DIO however, initiates a positive feedback loop, which perpetuates inflammation and further decimates immune system's capacity to resist threats and to restore order.
CONCLUSION: While the basic obesity-inflammation-disease road map has been outlined, many questions remain. Multiple areas of immunometabolism and meta inflammation require deeper understanding, but two key recommendations for future studies stand out. First, since it is easier to prevent obesity than to reverse it, attention should be focused on elucidating the endocrine role of foodstuff. Second, to find cures for chronic conditions of the ever growing obese population, scientists must elucidate the mechanism of obesity-induced inflammation's function in diminishing immune system's capacity.
Subjects/Keywords: Health sciences; Immune system; Inflammation; Obesity
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Fayngersh, R. (2014). Role of obesity in modulating the immune system. (Masters Thesis). Boston University. Retrieved from http://hdl.handle.net/2144/15342
Chicago Manual of Style (16th Edition):
Fayngersh, Roman. “Role of obesity in modulating the immune system.” 2014. Masters Thesis, Boston University. Accessed March 07, 2021.
http://hdl.handle.net/2144/15342.
MLA Handbook (7th Edition):
Fayngersh, Roman. “Role of obesity in modulating the immune system.” 2014. Web. 07 Mar 2021.
Vancouver:
Fayngersh R. Role of obesity in modulating the immune system. [Internet] [Masters thesis]. Boston University; 2014. [cited 2021 Mar 07].
Available from: http://hdl.handle.net/2144/15342.
Council of Science Editors:
Fayngersh R. Role of obesity in modulating the immune system. [Masters Thesis]. Boston University; 2014. Available from: http://hdl.handle.net/2144/15342

University of Guelph
26.
Slocket, John.
Dynamic Strategy Generation in Computer Games using Artificial Immune Systems.
Degree: MS, Department of Computing and Information Science, 2012, University of Guelph
URL: https://atrium.lib.uoguelph.ca/xmlui/handle/10214/3289
This thesis investigates the use of an Artificial Immune System as a method for dynamically creating computer game strategies in a non deterministic environment
Advisors/Committee Members: Kremer, Stefan (advisor).
Subjects/Keywords: Strategy Generation; Computer Games; Artifical Immune System
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Slocket, J. (2012). Dynamic Strategy Generation in Computer Games using Artificial Immune Systems. (Masters Thesis). University of Guelph. Retrieved from https://atrium.lib.uoguelph.ca/xmlui/handle/10214/3289
Chicago Manual of Style (16th Edition):
Slocket, John. “Dynamic Strategy Generation in Computer Games using Artificial Immune Systems.” 2012. Masters Thesis, University of Guelph. Accessed March 07, 2021.
https://atrium.lib.uoguelph.ca/xmlui/handle/10214/3289.
MLA Handbook (7th Edition):
Slocket, John. “Dynamic Strategy Generation in Computer Games using Artificial Immune Systems.” 2012. Web. 07 Mar 2021.
Vancouver:
Slocket J. Dynamic Strategy Generation in Computer Games using Artificial Immune Systems. [Internet] [Masters thesis]. University of Guelph; 2012. [cited 2021 Mar 07].
Available from: https://atrium.lib.uoguelph.ca/xmlui/handle/10214/3289.
Council of Science Editors:
Slocket J. Dynamic Strategy Generation in Computer Games using Artificial Immune Systems. [Masters Thesis]. University of Guelph; 2012. Available from: https://atrium.lib.uoguelph.ca/xmlui/handle/10214/3289

Freie Universität Berlin
27.
Wolf, Susanne.
Einfluss von physischer Aktivität auf die Plastizität des Gehirns.
Degree: 2020, Freie Universität Berlin
URL: http://dx.doi.org/10.17169/refubium-27565
► Im Tierreich sind ein gesunder Geist und Körper die Voraussetzung für das Überleben. Obwohl das Paradigma "Überleben des Stärkeren" für den Menschen nicht mehr gilt,…
(more)
▼ Im Tierreich sind ein gesunder Geist und Körper die Voraussetzung für das Überleben. Obwohl das Paradigma "Überleben des Stärkeren" für den Menschen nicht mehr gilt, ist die Gesundheit von Geist und Körper sehr wichtig für das Wohlbefinden und die Lebensqualität im Allgemeinen. Ohne Zweifel ist eine gesunde Bevölkerung auch produktiver und die Kosten für medizinische Behandlungen sind begrenzt. Körperliche Aktivität erhält und verbessert viele Organsysteme des Körpers. In den späten 1990er Jahren wurde deutlich, dass körperliche Aktivität auch die Plastizität des Gehirns beeinflussen kann, indem die Anzahl der neu gebildeten Zellen im Hippocampus verbessert wird - ein Bereich, der auch als Tor zur Gedächtnisbildung bekannt ist.
In dieser Monographie präsentiere und diskutiere ich fünf Publikationen, die sich mit der Regulation von zellbasierter Plastizität des Gehirns (Neurogenese) durch verschiedene Stimuli befassen. Hierzu nutze ich Tiermodelle für Schizophrenie sowie Knockout-Stämme für Teile des Immun- und Endocannabinoid-Systems. Ein zentraler Stimulus, den ich in fast allen Arbeiten untersuche ist freiwillige körperliche Aktivität. Alle Publikationen betonen, dass körperliche Aktivität für Neurogenese, kognitive Funktion und Verhalten auch unter pathologischen Bedingungen vorteilhaft ist. Darüber hinaus zeigen die Ergebnisse, wie die multidisziplinäre Untersuchung von Mechanismen, die der Neurogenese und der neuronalen Plastizität zugrunde liegen zu potenziellen therapeutischen Zwecken genutzt werden könnte. In der letzten Arbeit schlage ich vor, dass zusätzlich oder als Alternative zur physischen Aktivität auch die Gabe von Probiotika Neurogenese und Kognition positiv beeinflussen können.
Advisors/Committee Members: female (gender), Streit, Wolfgang, J. (firstReferee), Waisman, Ari (furtherReferee).
Subjects/Keywords: adult neurogenesis; immune system; hippocampus; ddc:610
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Wolf, S. (2020). Einfluss von physischer Aktivität auf die Plastizität des Gehirns. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-27565
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Wolf, Susanne. “Einfluss von physischer Aktivität auf die Plastizität des Gehirns.” 2020. Thesis, Freie Universität Berlin. Accessed March 07, 2021.
http://dx.doi.org/10.17169/refubium-27565.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Wolf, Susanne. “Einfluss von physischer Aktivität auf die Plastizität des Gehirns.” 2020. Web. 07 Mar 2021.
Vancouver:
Wolf S. Einfluss von physischer Aktivität auf die Plastizität des Gehirns. [Internet] [Thesis]. Freie Universität Berlin; 2020. [cited 2021 Mar 07].
Available from: http://dx.doi.org/10.17169/refubium-27565.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Wolf S. Einfluss von physischer Aktivität auf die Plastizität des Gehirns. [Thesis]. Freie Universität Berlin; 2020. Available from: http://dx.doi.org/10.17169/refubium-27565
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University College London (University of London)
28.
Coope, Helen Jane.
Analysis of the regulation of NFκB by TPL-2 kinase.
Degree: PhD, 2001, University College London (University of London)
URL: https://discovery.ucl.ac.uk/id/eprint/10101214/
;
https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.249176
► NFκB is a ubiquitously expressed transcription factor of particular importance in the immune system. Several signalling pathways regulate NFκB activation, which occurs following the degradation…
(more)
▼ NFκB is a ubiquitously expressed transcription factor of particular importance in the immune system. Several signalling pathways regulate NFκB activation, which occurs following the degradation of inhibitory IκB proteins. One pathway of NFκB activation is the signal-induced degradation of NFκB1 p105, when this occurs, associated NFκB proteins transfer to the nucleus. TPL-2 is a proto-oncogene encoding a serine/threonine kinase, which interacts with NFκB1 p105 and regulates its degradation. The aims of the present study are to investigate the regulation of NFκB1 p105 degradation by TPL-2 and clarify the physiological circumstances in which this is important. Studies of NFκB knockout and transgenic animals reveal roles for NFKB in T cell development and function. TPL-2 is expressed in T cell rich organs. However, in the present study, transgenic mice expressing TPL-2 or dominant negative TPL-2 in the T cell lineage show no defects in thymocyte development, T cell proliferation, IL-2 and TNFα production or NFκB activation. Using stable cell lines, it is shown that TNFα stimulation but not CD3 and CD28 costimulation is a potent stimulus for NFKB1 p105 degradation in T cells. Expression of dominant negative TPL-2 inhibits NFκB1 p105 degradation in these cells, whereas ERK, JNK and P38 activation are unaffected. LPS is a potent inducer of NFKB1 p105 degradation in the monocyte-macrophage cell line THP-1, which coincides with the activation of the IKK kinases. Expression of dominant negative TPL-2 in these cells inhibits LPS induced NFκB1 p105 degradation, ERK activation and transcription of the TNFα gene. Taken together, these data suggest that TPL-2 may function in regulation of monocyte or macrophage responses to LPS.
Subjects/Keywords: 610; Immune system
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Coope, H. J. (2001). Analysis of the regulation of NFκB by TPL-2 kinase. (Doctoral Dissertation). University College London (University of London). Retrieved from https://discovery.ucl.ac.uk/id/eprint/10101214/ ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.249176
Chicago Manual of Style (16th Edition):
Coope, Helen Jane. “Analysis of the regulation of NFκB by TPL-2 kinase.” 2001. Doctoral Dissertation, University College London (University of London). Accessed March 07, 2021.
https://discovery.ucl.ac.uk/id/eprint/10101214/ ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.249176.
MLA Handbook (7th Edition):
Coope, Helen Jane. “Analysis of the regulation of NFκB by TPL-2 kinase.” 2001. Web. 07 Mar 2021.
Vancouver:
Coope HJ. Analysis of the regulation of NFκB by TPL-2 kinase. [Internet] [Doctoral dissertation]. University College London (University of London); 2001. [cited 2021 Mar 07].
Available from: https://discovery.ucl.ac.uk/id/eprint/10101214/ ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.249176.
Council of Science Editors:
Coope HJ. Analysis of the regulation of NFκB by TPL-2 kinase. [Doctoral Dissertation]. University College London (University of London); 2001. Available from: https://discovery.ucl.ac.uk/id/eprint/10101214/ ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.249176

University College London (University of London)
29.
Blackford, Jeanette.
A study of the rabbit leucocyte integrins and their role in cell adhesion.
Degree: PhD, 1996, University College London (University of London)
URL: https://discovery.ucl.ac.uk/id/eprint/10100669/
;
https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.363003
► It is clear that the leucocyte integrins play an important role in many cell-cell interactions within the immune system. While such interactions may be necessary…
(more)
▼ It is clear that the leucocyte integrins play an important role in many cell-cell interactions within the immune system. While such interactions may be necessary for an effective immune response, they must be tightly controlled since the inappropriate activation of leucocytes, as in autoimmune diseases, results in pathology. An understanding of the molecular interactions and activation states of the leucocyte integrins is required to allow development and evaluation of therapeutic strategies. The rabbit provides a suitable species in which to study these processes. A new rabbit CD8+ T cell line, BJ/873, has been characterised by flow cytometry and together with the rabbit CD4+ T cell line, RL-5, has been used to produce a panel of mAb which recognise a variety of rabbit cell surface antigens. mAb which recognise rabbit CD 18, CD 11a and CD 11c have been produced and characterised using cell-surface immunofluorescence and flow cytometry, immunohistochemical staining of rabbit lymphoid tissues. Western blotting and immunostaining, metabolic and cell-surface labelling of cell lines followed by immunoprecipitation and N-terminal amino-acid sequence analysis of immunoaffinity purified proteins. Using these, and previously characterised mAb, the expression of the leucocyte integrins by rabbit lymphoid tissues was investigated by flow cytometry. Following stimulation with phorbol-ester the RL-5 cells were found to homotypically aggregate and inhibition studies revealed that this aggregation is LFA-1 dependent. A number of the anti-LFA-1 mAb produced also stimulated LFA-1 dependent aggregation of the RL-5 cells. The ligand for rabbit LFA-1 in this system was not identified. Three anti-CD11c mAb induced homotypic aggregation of BJ/873 cells. mAb blocking studies showed that anti-CD 18 and anti-ICAM-1 mAb were inhibitory and suggested that in the rabbit, pl50,95 acts as a ligand for ICAM-1. The BJ/873 cells co-express LFA-1 and pi50, 95 as well as other adhesion molecules. Before a definitive statement concerning the interaction of rabbit pi50, 95 with ICAM-1 can be made, these molecules must be expressed in isolation. A probe for rabbit CD 18 was produced by PCR and used to screen a rabbit spleen cDNA library. A single clone containing a 2.3kb insert was selected and sequenced. The clone does not code for the N-terminal portion of CD 18 and this region has been amplified by PCR and sequenced.
Subjects/Keywords: 610; Immune system
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Blackford, J. (1996). A study of the rabbit leucocyte integrins and their role in cell adhesion. (Doctoral Dissertation). University College London (University of London). Retrieved from https://discovery.ucl.ac.uk/id/eprint/10100669/ ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.363003
Chicago Manual of Style (16th Edition):
Blackford, Jeanette. “A study of the rabbit leucocyte integrins and their role in cell adhesion.” 1996. Doctoral Dissertation, University College London (University of London). Accessed March 07, 2021.
https://discovery.ucl.ac.uk/id/eprint/10100669/ ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.363003.
MLA Handbook (7th Edition):
Blackford, Jeanette. “A study of the rabbit leucocyte integrins and their role in cell adhesion.” 1996. Web. 07 Mar 2021.
Vancouver:
Blackford J. A study of the rabbit leucocyte integrins and their role in cell adhesion. [Internet] [Doctoral dissertation]. University College London (University of London); 1996. [cited 2021 Mar 07].
Available from: https://discovery.ucl.ac.uk/id/eprint/10100669/ ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.363003.
Council of Science Editors:
Blackford J. A study of the rabbit leucocyte integrins and their role in cell adhesion. [Doctoral Dissertation]. University College London (University of London); 1996. Available from: https://discovery.ucl.ac.uk/id/eprint/10100669/ ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.363003

University of Ottawa
30.
Lansdell, Casey.
Characterization of Surgery-Induced Vaccine Dysfunction in a Therapeutic Murine Melanoma Model
.
Degree: 2016, University of Ottawa
URL: http://hdl.handle.net/10393/34269
► Surgical resection is the leading treatment of most solid tumours, however surgical stress creates an immunosuppressive environment that promotes metastases. A global decrease in T…
(more)
▼ Surgical resection is the leading treatment of most solid tumours, however surgical stress creates an immunosuppressive environment that promotes metastases. A global decrease in T cell numbers and function post-surgery has been documented. However, the effect on tumour associated antigen (TAA)-specific T cells remains unclear. The objective is therefore to evaluate the impact of surgical stress on TAA-specific adaptive T cell immunity. Melanoma tumour-bearing C57BL/6 mice were vaccinated using AdhDCT, an adenovirus expressing dopochrome totaumerase (DCT), a melanoma TAA, and underwent abdominal nephrectomies to induce surgical stress. Surgical stress decreased the number of splenic cytotoxic T cells (CTLs) and their capacity to produce immunostimulatory cytokines (IFNγ and TNFα), as determined by flow cytometry. A perioperative accumulation in CTL-suppressive MDSCs was observed and demonstrated a direct suppression of CTL IFNγ and TNFα production and secretion. Understanding the mechanisms of perioperative T cell dysfunction will facilitate the development of targeted immunotherapies.
Subjects/Keywords: Cancer;
Surgery;
T cells;
Immune system
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APA (6th Edition):
Lansdell, C. (2016). Characterization of Surgery-Induced Vaccine Dysfunction in a Therapeutic Murine Melanoma Model
. (Thesis). University of Ottawa. Retrieved from http://hdl.handle.net/10393/34269
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Lansdell, Casey. “Characterization of Surgery-Induced Vaccine Dysfunction in a Therapeutic Murine Melanoma Model
.” 2016. Thesis, University of Ottawa. Accessed March 07, 2021.
http://hdl.handle.net/10393/34269.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Lansdell, Casey. “Characterization of Surgery-Induced Vaccine Dysfunction in a Therapeutic Murine Melanoma Model
.” 2016. Web. 07 Mar 2021.
Vancouver:
Lansdell C. Characterization of Surgery-Induced Vaccine Dysfunction in a Therapeutic Murine Melanoma Model
. [Internet] [Thesis]. University of Ottawa; 2016. [cited 2021 Mar 07].
Available from: http://hdl.handle.net/10393/34269.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Lansdell C. Characterization of Surgery-Induced Vaccine Dysfunction in a Therapeutic Murine Melanoma Model
. [Thesis]. University of Ottawa; 2016. Available from: http://hdl.handle.net/10393/34269
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
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