subject:(IgA)

1. 臼井, 文人. 腸管IgA抗体が認識する腸内細菌の共通抗原解析 : Common antigen analysis of intestinal bacteria that intestinal tract IgA antibody recognizes; チョウカン IgA コウタイガニンシキスルチョウナイサイキンノキョウツウコウゲンカイセキ.

Degree: 博士(バイオサイエンス), 2018, Nara Institute of Science and Technology / 奈良先端科学技術大学院大学

URL: http://hdl.handle.net/10061/12351

Subjects/Keywords: IgA

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APA (6^th Edition):

臼井, �. (2018). 腸管IgA抗体が認識する腸内細菌の共通抗原解析 : Common antigen analysis of intestinal bacteria that intestinal tract IgA antibody recognizes; チョウカン IgA コウタイガニンシキスルチョウナイサイキンノキョウツウコウゲンカイセキ. (Thesis). Nara Institute of Science and Technology / 奈良先端科学技術大学院大学. Retrieved from http://hdl.handle.net/10061/12351

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

臼井, 文人. “腸管IgA抗体が認識する腸内細菌の共通抗原解析 : Common antigen analysis of intestinal bacteria that intestinal tract IgA antibody recognizes; チョウカン IgA コウタイガニンシキスルチョウナイサイキンノキョウツウコウゲンカイセキ.” 2018. Thesis, Nara Institute of Science and Technology / 奈良先端科学技術大学院大学. Accessed February 26, 2021. http://hdl.handle.net/10061/12351.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

臼井, 文人. “腸管IgA抗体が認識する腸内細菌の共通抗原解析 : Common antigen analysis of intestinal bacteria that intestinal tract IgA antibody recognizes; チョウカン IgA コウタイガニンシキスルチョウナイサイキンノキョウツウコウゲンカイセキ.” 2018. Web. 26 Feb 2021.

Vancouver:

臼井 �. 腸管IgA抗体が認識する腸内細菌の共通抗原解析 : Common antigen analysis of intestinal bacteria that intestinal tract IgA antibody recognizes; チョウカン IgA コウタイガニンシキスルチョウナイサイキンノキョウツウコウゲンカイセキ. [Internet] [Thesis]. Nara Institute of Science and Technology / 奈良先端科学技術大学院大学; 2018. [cited 2021 Feb 26]. Available from: http://hdl.handle.net/10061/12351.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

臼井 �. 腸管IgA抗体が認識する腸内細菌の共通抗原解析 : Common antigen analysis of intestinal bacteria that intestinal tract IgA antibody recognizes; チョウカン IgA コウタイガニンシキスルチョウナイサイキンノキョウツウコウゲンカイセキ. [Thesis]. Nara Institute of Science and Technology / 奈良先端科学技術大学院大学; 2018. Available from: http://hdl.handle.net/10061/12351

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Cornell University

2. Cullender, Tyler. Tlr5 And Anti-Flagellin Iga Are Critical Elements To Quenching Bacterial Motility In The Mammalian Gut.

Degree: PhD, Microbiology, 2013, Cornell University

URL: http://hdl.handle.net/1813/34086

► The mammalian gut contains an incredibly diverse and abundant bacterial community that makes essential contributions to host metabolism and immune system priming. The close proximity… (more)

▼ The mammalian gut contains an incredibly diverse and abundant bacterial community that makes essential contributions to host metabolism and immune system priming. The close proximity of the intestinal epithelium with the gut microbiota poses serious challenges to the host, who in turn has developed a complex set of physical and immunological mechanisms to effectively manage this host-microbe relationship. A defect in any one of these mechanisms can result in opportunistic invasion of host tissues by otherwise commensal bacteria and this breakdown in homeostasis may contribute to numerous metabolic and gastrointestinal pathologies. Here, I investigate the role of two such mechanisms in maintaining homeostasis: Toll-like receptor 5 (TLR5), the innate immune receptor for bacterial flagellin, as well as IgA, which has previously been indicated to be aberrant in abundance and antigen specificity in the absence of TLR5. Using metatranscriptomics and biochemical assays, I found that TLR5-/- mice harbor a bacterial community that exhibits increased flagellation. I also found that TLR5 is required to synthesize the amount of anti-flagellin IgA observed in healthy WT mice, and flagellin load appears to share an inverse relationship with levels of anti-flagellin IgA. I performed 16S rRNA analysis of the gut microbiota in mice with or without the capacity for producing IgA to better understand how IgA influences the stability and resilience of the bacterial community. Indeed, the lack of IgA resulted in reduced temporal stability and reduced community evenness, as well as increased susceptibility to antibiotic-induced perturbation. To specifically investigate the influence of TLR5 on IgA coating of the gut microbiota, I used fluorescence activated cell sorting (FACS) combined with 16S rRNA analysis and found that the bacterial community of TLR5-/- mice displays an aberrant profile of IgA coating, including reduced coating of Proteobacteria and increased coating of Firmicutes. With a combination of immunohistochemistry, fluorescent in situ hybridization, and fluorescent microscopy of intestinal tissues, I observed that TLR5-/- mice have a defective mucosal barrier that results in bacterial invasion of villi in the small intestine and penetration deep into the colonic mucus layer. Together, these results highlight the critical role of TLR5 in maintaining gut homeostasis through directing the synthesis of anti-flagellin IgA and thus reducing levels of flagellation and motility in the bacterial community. Advisors/Committee Members: Ley, Ruth E. (chair), Denkers, Eric Young (committee member), Stanhope, Michael J (committee member).

Subjects/Keywords: TLR5; IgA; flagellin

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APA (6^th Edition):

Cullender, T. (2013). Tlr5 And Anti-Flagellin Iga Are Critical Elements To Quenching Bacterial Motility In The Mammalian Gut. (Doctoral Dissertation). Cornell University. Retrieved from http://hdl.handle.net/1813/34086

Chicago Manual of Style (16^th Edition):

Cullender, Tyler. “Tlr5 And Anti-Flagellin Iga Are Critical Elements To Quenching Bacterial Motility In The Mammalian Gut.” 2013. Doctoral Dissertation, Cornell University. Accessed February 26, 2021. http://hdl.handle.net/1813/34086.

MLA Handbook (7^th Edition):

Cullender, Tyler. “Tlr5 And Anti-Flagellin Iga Are Critical Elements To Quenching Bacterial Motility In The Mammalian Gut.” 2013. Web. 26 Feb 2021.

Vancouver:

Cullender T. Tlr5 And Anti-Flagellin Iga Are Critical Elements To Quenching Bacterial Motility In The Mammalian Gut. [Internet] [Doctoral dissertation]. Cornell University; 2013. [cited 2021 Feb 26]. Available from: http://hdl.handle.net/1813/34086.

Council of Science Editors:

Cullender T. Tlr5 And Anti-Flagellin Iga Are Critical Elements To Quenching Bacterial Motility In The Mammalian Gut. [Doctoral Dissertation]. Cornell University; 2013. Available from: http://hdl.handle.net/1813/34086

University of Helsinki

3. Hirvonen, Marjatta. Determination of low concentrations of immunoglobulin A (IgA) and anti-IgA = Matalien IgA-pitoisuuksien ja IgA-vasta-aineiden määrittäminen.

Degree: 1995, University of Helsinki

URL: http://hdl.handle.net/10138/159263

Subjects/Keywords: anti-IgA; IgA; IgA-puutos; EIA; Biokemia; anti-IgA; IgA; IgA-puutos; EIA

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APA (6^th Edition):

Hirvonen, M. (1995). Determination of low concentrations of immunoglobulin A (IgA) and anti-IgA = Matalien IgA-pitoisuuksien ja IgA-vasta-aineiden määrittäminen. (Thesis). University of Helsinki. Retrieved from http://hdl.handle.net/10138/159263

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Hirvonen, Marjatta. “Determination of low concentrations of immunoglobulin A (IgA) and anti-IgA = Matalien IgA-pitoisuuksien ja IgA-vasta-aineiden määrittäminen.” 1995. Thesis, University of Helsinki. Accessed February 26, 2021. http://hdl.handle.net/10138/159263.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Hirvonen, Marjatta. “Determination of low concentrations of immunoglobulin A (IgA) and anti-IgA = Matalien IgA-pitoisuuksien ja IgA-vasta-aineiden määrittäminen.” 1995. Web. 26 Feb 2021.

Vancouver:

Hirvonen M. Determination of low concentrations of immunoglobulin A (IgA) and anti-IgA = Matalien IgA-pitoisuuksien ja IgA-vasta-aineiden määrittäminen. [Internet] [Thesis]. University of Helsinki; 1995. [cited 2021 Feb 26]. Available from: http://hdl.handle.net/10138/159263.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Hirvonen M. Determination of low concentrations of immunoglobulin A (IgA) and anti-IgA = Matalien IgA-pitoisuuksien ja IgA-vasta-aineiden määrittäminen. [Thesis]. University of Helsinki; 1995. Available from: http://hdl.handle.net/10138/159263

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Michigan State University

4. Rasooly, Linda. Self-reactive polyspecific IgA antibodies in vomitoxin-induced glomerulonephritis.

Degree: PhD, Department of Microbiology and Public Health, 1992, Michigan State University

URL: http://etd.lib.msu.edu/islandora/object/etd:21892

Subjects/Keywords: IgA glomerulonephritis

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APA (6^th Edition):

Rasooly, L. (1992). Self-reactive polyspecific IgA antibodies in vomitoxin-induced glomerulonephritis. (Doctoral Dissertation). Michigan State University. Retrieved from http://etd.lib.msu.edu/islandora/object/etd:21892

Chicago Manual of Style (16^th Edition):

Rasooly, Linda. “Self-reactive polyspecific IgA antibodies in vomitoxin-induced glomerulonephritis.” 1992. Doctoral Dissertation, Michigan State University. Accessed February 26, 2021. http://etd.lib.msu.edu/islandora/object/etd:21892.

MLA Handbook (7^th Edition):

Rasooly, Linda. “Self-reactive polyspecific IgA antibodies in vomitoxin-induced glomerulonephritis.” 1992. Web. 26 Feb 2021.

Vancouver:

Rasooly L. Self-reactive polyspecific IgA antibodies in vomitoxin-induced glomerulonephritis. [Internet] [Doctoral dissertation]. Michigan State University; 1992. [cited 2021 Feb 26]. Available from: http://etd.lib.msu.edu/islandora/object/etd:21892.

Council of Science Editors:

Rasooly L. Self-reactive polyspecific IgA antibodies in vomitoxin-induced glomerulonephritis. [Doctoral Dissertation]. Michigan State University; 1992. Available from: http://etd.lib.msu.edu/islandora/object/etd:21892

Kansas State University

5. Bornheim, Heather. Priming antibody responses against BRSV induced in beef calves through early vaccination.: Antibody responses induced in beef calves through early vaccination.

Degree: MSin Biomedical Sciences, Department of Biomedical Sciences, 2020, Kansas State University

URL: http://hdl.handle.net/2097/40876

► Bovine respiratory syncytial virus (BRSV) plays an important role in the presentation of bovine respiratory disease (BRD) in young beef calves; however, current vaccination protocols… (more)

▼ Bovine respiratory syncytial virus (BRSV) plays an important role in the presentation of bovine respiratory disease (BRD) in young beef calves; however, current vaccination protocols against BRSV have not significantly reduced BRD-associated morbidity and mortality. The objective of this study was to evaluate serum and nasal secretion antibody responses to BRSV in beef calves following vaccination with two different protocols. Within 24-hours-of-life, sixty purebred beef calves were assigned to one of three different treatment groups. Group IN VAC received an intranasal (IN) modified-live (MLV) BRSV vaccine at birth and a subcutaneous (SQ) MLV BRSV vaccine at 2-months. Group SQ VAC received a SQ MLV BRSV vaccine at birth and an IN MLV BRSV vaccine at 2-months while group NO VAC was not vaccinated at birth and received an IN MLV BRSV vaccine at 2-months-of-age. Nasal secretion and serum samples were collected for assessment of BRSV antibodies prior to vaccination at <24 hours, 2-months, and 6-months-of-age. The titers of BRSV antibodies in nasal secretions and serum were similar among treatment groups. At birth, the mean log-transformed BRSV nasal IgA titers were negligible in all groups. At 2-months-of-age, the mean log-transformed BRSV nasal IgA titers in IN-SC VAC, SC-IN VAC, and NO-IN VAC calves were 192.84, 224.49, and 114.71, respectively. At 6-months-of-age, the mean log-transformed BRSV nasal IgA titers in IN-SC, SC-IN, and NO-IN calves were 178.84, 159.33, and 266.62, respectively; however, statistical significance in BRSV IgA titers was not detected among treatment groups at any time point. The model-adjusted mean-Log2 serum BRSV antibody titers were similar among calves from all treatment groups at each sampling point. Early vaccination with MLV BRSV vaccines in a combination protocol at birth and at 2-months-of-age was not different from single IN MLV vaccination at 2-months-of-age inducing nasal or serum BRSV-specific antibody responses in beef calves under the conditions of this study. Advisors/Committee Members: Emily Reppert.

Subjects/Keywords: BRSV; Vaccination; Priming; IgA; Intranasal

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APA (6^th Edition):

Bornheim, H. (2020). Priming antibody responses against BRSV induced in beef calves through early vaccination.: Antibody responses induced in beef calves through early vaccination. (Masters Thesis). Kansas State University. Retrieved from http://hdl.handle.net/2097/40876

Chicago Manual of Style (16^th Edition):

Bornheim, Heather. “Priming antibody responses against BRSV induced in beef calves through early vaccination.: Antibody responses induced in beef calves through early vaccination.” 2020. Masters Thesis, Kansas State University. Accessed February 26, 2021. http://hdl.handle.net/2097/40876.

MLA Handbook (7^th Edition):

Bornheim, Heather. “Priming antibody responses against BRSV induced in beef calves through early vaccination.: Antibody responses induced in beef calves through early vaccination.” 2020. Web. 26 Feb 2021.

Vancouver:

Bornheim H. Priming antibody responses against BRSV induced in beef calves through early vaccination.: Antibody responses induced in beef calves through early vaccination. [Internet] [Masters thesis]. Kansas State University; 2020. [cited 2021 Feb 26]. Available from: http://hdl.handle.net/2097/40876.

Council of Science Editors:

Bornheim H. Priming antibody responses against BRSV induced in beef calves through early vaccination.: Antibody responses induced in beef calves through early vaccination. [Masters Thesis]. Kansas State University; 2020. Available from: http://hdl.handle.net/2097/40876

University of Cincinnati

6. Betz, Kristina J, B.A. Immunoglobulin A Dynamics in Rotavirus and S. typhimurium Infection.

Degree: PhD, Medicine: Immunology, 2016, University of Cincinnati

URL: http://rave.ohiolink.edu/etdc/view?acc_num=ucin1467988062

► IgA is the most abundant antibody in the human body, and has been shown to play diverse roles in the immune system ranging from homeostasis… (more)

Subjects/Keywords: Immunology; IgA; undernutrition; Rotavirus; Salmonella

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APA (6^th Edition):

Betz, Kristina J, B. A. (2016). Immunoglobulin A Dynamics in Rotavirus and S. typhimurium Infection. (Doctoral Dissertation). University of Cincinnati. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=ucin1467988062

Chicago Manual of Style (16^th Edition):

Betz, Kristina J, B A. “Immunoglobulin A Dynamics in Rotavirus and S. typhimurium Infection.” 2016. Doctoral Dissertation, University of Cincinnati. Accessed February 26, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1467988062.

MLA Handbook (7^th Edition):

Betz, Kristina J, B A. “Immunoglobulin A Dynamics in Rotavirus and S. typhimurium Infection.” 2016. Web. 26 Feb 2021.

Vancouver:

Betz, Kristina J BA. Immunoglobulin A Dynamics in Rotavirus and S. typhimurium Infection. [Internet] [Doctoral dissertation]. University of Cincinnati; 2016. [cited 2021 Feb 26]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=ucin1467988062.

Council of Science Editors:

Betz, Kristina J BA. Immunoglobulin A Dynamics in Rotavirus and S. typhimurium Infection. [Doctoral Dissertation]. University of Cincinnati; 2016. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=ucin1467988062

Colorado State University

7. Pearson, Morgan. Mucosal and systemic immune correlates of protection against feline enteric coronavirus infection.

Degree: MS(M.S.), Microbiology, Immunology, and Pathology, 2019, Colorado State University

URL: http://hdl.handle.net/10217/199863

► Feline infectious peritonitis (FIP) is a disease with high mortality that results from a mutation in the genome of the relatively harmless and ubiquitous feline… (more)

▼ Feline infectious peritonitis (FIP) is a disease with high mortality that results from a mutation in the genome of the relatively harmless and ubiquitous feline coronavirus (FCoV) (Licitra, Millet et al. 2013). FIP causes a deadly effusive and/or granulomatous disease in cats (Kipar, May et al. 2005). Because FIP is always fatal, our aim is to aid with the development of a vaccine against the parent virus FCoV. The goal of this study is to complete a comprehensive assessment of the mucosal immune response associated with FCoV infection and clearance. Previous research has shown that cats infected with FCoV can clear the virus, or they can become intermittent or persistent virus shedders (Marks 2016). It is thought that rapid waning of the humoral immune response predisposes cats to reinfection (Myrrha, Silva et al. 2011). A closed cat colony with circulating FCoV infection was studied longitudinally to assess mucosal immune correlates of protection. Blood and fecal samples were collected monthly and colonic biopsies were obtained at an arbitrary time 0. Virologic assessment included PCR detection of virus in feces and colonic tissue. Immunological assessment included FECV-specific serum IgG and fecal IgA. Lamina propria lymphocytes from colon biopsies were phenotyped using flow cytometry and were assessed for FCoV-specific IgA and IFNγ expression by ELISPOT. Expression of IL17 and FoxP3 was measured by qRT-PCR. Although histopathology of colonic biopsies from cats shedding virus was unremarkable, an inflammatory state was indicated by total IgA producing cells, IFNγ production, and increased IL17:FoxP3. FCoV-specific IgA was also associated with viral shedding. Taken together, results indicate mucosal and systemic antibody responses are responsible for limiting FECV infection while cell-mediated responses were not detected. Therefore, a vaccine strategy targeting antibody induction via a mucosal route may provide protection against FECV infection. Advisors/Committee Members: Dean, Gregg (advisor), Schountz, Tony (committee member), Webb, Craig (committee member), Avery, Anne (committee member).

Subjects/Keywords: FIP; mucosal; FECV; IgA

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APA (6^th Edition):

Pearson, M. (2019). Mucosal and systemic immune correlates of protection against feline enteric coronavirus infection. (Masters Thesis). Colorado State University. Retrieved from http://hdl.handle.net/10217/199863

Chicago Manual of Style (16^th Edition):

Pearson, Morgan. “Mucosal and systemic immune correlates of protection against feline enteric coronavirus infection.” 2019. Masters Thesis, Colorado State University. Accessed February 26, 2021. http://hdl.handle.net/10217/199863.

MLA Handbook (7^th Edition):

Pearson, Morgan. “Mucosal and systemic immune correlates of protection against feline enteric coronavirus infection.” 2019. Web. 26 Feb 2021.

Vancouver:

Pearson M. Mucosal and systemic immune correlates of protection against feline enteric coronavirus infection. [Internet] [Masters thesis]. Colorado State University; 2019. [cited 2021 Feb 26]. Available from: http://hdl.handle.net/10217/199863.

Council of Science Editors:

Pearson M. Mucosal and systemic immune correlates of protection against feline enteric coronavirus infection. [Masters Thesis]. Colorado State University; 2019. Available from: http://hdl.handle.net/10217/199863

Universidade Federal da Bahia

8. Andrea Padre Peixoto. Detecção do Papilomavírus humano na cavidade bucal de pacientes com infecção por este vírus na mucosa cérvico-vaginal.

Degree: 2006, Universidade Federal da Bahia

URL: http://www.bibliotecadigital.ufba.br/tde_busca/arquivo.php?codArquivo=604

►

Human Papillomavirus (HPV) is the most frequent cause of sexual diseases. There are more than 100 different kinds of HPV and 24 have a close… (more)

▼

Human Papillomavirus (HPV) is the most frequent cause of sexual diseases. There are more than 100 different kinds of HPV and 24 have a close relationship to HPV oral infection. As yet, the route of infection to the oral cavity has not been established, nevertheless, selftransmission and close contact with infected individuals are considered the most probable ways of infection. The main aspects of this study were: 1) to determine the prevalence of oral HPV infection in women who have HPV infection in the cervical mucosa; 2) to detect anti-HPV immunoglobulin A in oral fluid and 3) to evaluate the risk factors for this virus infection. Samples of saliva and a mouth swab were colected in 100 patients and the presence of viral DNA in the oral epithelial cells was determined by polymerase chain reaction (PCR), using the primers (MY09-MY11). Indiret immunofluorencence was employed in the detection of IgA in saliva. Results show that 81% of oral epithelial cells samples were positive for DNA- HPV and 44% of oral fluid samples for IgA anti-HPV. This results of low specific IgA prevalence and high percentual of oral epithelial cells infected would be related with early oral HPV infection in some cases. It was also observed that the occurrence of cervical relapse injuries determined higher prevalence of IgA in the saliva. However, future studies will be necessary to better evaluate the immune response in HPV oral infection. Human Papillomavirus (HPV) is the most frequent cause of sexual diseases. There are more than 100 different kinds of HPV and 24 have a close relationship to HPV oral infection. As yet, the route of infection to the oral cavity has not been established, nevertheless, selftransmission and close contact with infected individuals are considered the most probable ways of infection. The main aspects of this study were: 1) to determine the prevalence of oral HPV infection in women who have HPV infection in the cervical mucosa; 2) to detect anti-HPV immunoglobulin A in oral fluid and 3) to evaluate the risk factors for this virus infection. Samples of saliva and a mouth swab were colected in 100 patients and the presence of viral DNA in the oral epithelial cells was determined by polymerase chain reaction (PCR), using the primers (MY09-MY11). Indiret immunofluorencence was employed in the detection of IgA in saliva. Results show that 81% of oral epithelial cells samples were positive for DNA- HPV and 44% of oral fluid samples for IgA anti-HPV. This results of low specific IgA prevalence and high percentual of oral epithelial cells infected would be related with early oral HPV infection in some cases. It was also observed that the occurrence of cervical relapse injuries determined higher prevalence of IgA in the saliva. However, future studies will be necessary to better evaluate the immune response in HPV oral infection.

O Papilomavírus humano (HPV) é o agente etiológico da doença sexualmente transmissível mais prevalente em todo o mundo. São conhecidos mais de 100 tipos diferentes deste vírus e aproximadamente…

Advisors/Committee Members: Gubio Soares Campos, Maria Luiza Brito de Sousa Atta, Helenemarie Schaer-Barbosa, Silvia Ines Sardi.

Subjects/Keywords: oral cavity; iga; Human papillomavirus; cavidade bucal; iga; IMUNOLOGIA; papilomavírus humano

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APA (6^th Edition):

Peixoto, A. P. (2006). Detecção do Papilomavírus humano na cavidade bucal de pacientes com infecção por este vírus na mucosa cérvico-vaginal. (Thesis). Universidade Federal da Bahia. Retrieved from http://www.bibliotecadigital.ufba.br/tde_busca/arquivo.php?codArquivo=604

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Peixoto, Andrea Padre. “Detecção do Papilomavírus humano na cavidade bucal de pacientes com infecção por este vírus na mucosa cérvico-vaginal.” 2006. Thesis, Universidade Federal da Bahia. Accessed February 26, 2021. http://www.bibliotecadigital.ufba.br/tde_busca/arquivo.php?codArquivo=604.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Peixoto, Andrea Padre. “Detecção do Papilomavírus humano na cavidade bucal de pacientes com infecção por este vírus na mucosa cérvico-vaginal.” 2006. Web. 26 Feb 2021.

Vancouver:

Peixoto AP. Detecção do Papilomavírus humano na cavidade bucal de pacientes com infecção por este vírus na mucosa cérvico-vaginal. [Internet] [Thesis]. Universidade Federal da Bahia; 2006. [cited 2021 Feb 26]. Available from: http://www.bibliotecadigital.ufba.br/tde_busca/arquivo.php?codArquivo=604.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Peixoto AP. Detecção do Papilomavírus humano na cavidade bucal de pacientes com infecção por este vírus na mucosa cérvico-vaginal. [Thesis]. Universidade Federal da Bahia; 2006. Available from: http://www.bibliotecadigital.ufba.br/tde_busca/arquivo.php?codArquivo=604

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

9. Gayet, Rémi. Impact de la réponse IgA dans une nouvelle stratégie de vaccination muqueuse contre Salmonella et dans la régulation de la réponse adaptative : Impact of IgA response on both a novel mucosal vaccine strategy against Salmonella and on adaptive immune response regulation.

Degree: Docteur es, Sciences de la vie et de la sante, 2018, Lyon

URL: http://www.theses.fr/2018LYSES015

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Les entérobactéries Salmonella sont divisées en plusieurs sérovars dont les quatre principaux Typhimurium, Enteritidis, Typhi et Paratyphi sont responsables soit de gastroentérites soit de fièvres… (more)

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Les entérobactéries Salmonella sont divisées en plusieurs sérovars dont les quatre principaux Typhimurium, Enteritidis, Typhi et Paratyphi sont responsables soit de gastroentérites soit de fièvres typhoïdes, à raison de plus de 90 millions de cas et 400 000 décès par an. L’apparition de souches multi-résistantes nécessite la mise en place d’une vaccination prophylactique muqueuse. L’environnement intestinal est caractérisé par une balance entre tolérance immunitaire et réaction inflammatoire régulée par les immunoglobulines (Ig) A sécrétoires. Les IgA des sécrétions muqueuses sont dimériques, les IgA sériques sont monomérique et deux isotypes ont été décrits chez l’Homme: IgA1 et IgA2. Nous avons tout d’abord exploré les fonctions des différents isotypes et isoformes des IgA humaines. Nous avons pu noter un rôle anti-inflammatoire des IgA1 à l’inverse d’un rôle pro-inflammatoire des IgA2 et nous avons souligné un processus de régulation de l’expression des récepteurs aux IgA par les IgA elles-mêmes ainsi qu’un axe IgA/lymphocytes T CD8 cytotoxiques. Nous avons ensuite mis en place un vaccin multivalent composé des antigènes SseB et OmpC de Salmonella liés à des Ig sécrétoires. Cette étude a mis en évidence une solide réponse immunitaire humorale et cellulaire spécifique aux antigènes couplés à des IgA ou IgM après vaccination intra-nasale au niveau systémique et muqueux. Par ailleurs, de plus fortes réponses humorales et systémiques spécifiques ont été observées en couplant à la fois OmpC et SseB sur l’IgA. Ce travail de thèse ouvre de nouvelles perspectives pour la mise en place de vaccins muqueux multivalents et pourrait apporter des réponses quant au rôle des IgA.

The enterobacteria Salmonella species are divided into several serovars such as Typhimurium, Enteritidis, Typhi and Paratyphi which are the major causative agents of either gastroenteritis or typhoid fever. They are responsible for more than 90 million cases and 400 000 deaths each year. The increase in multi-drug resistant strains requires the implementation of prophylactic mucosal vaccines. Besides, the intestinal environment is characterized by a balance between immune tolerance and inflammatory response tightly regulated by secretory immunoglobulins (Ig) A. Mucosal IgA are mainly dimeric, serum IgA monomeric and two IgA isotypes have been described in humans: IgA1 and IgA2. We firstly explored the functions of the different isotypes and isoforms of human IgA. We pointed out a pro-inflammatory role of IgA2 whereas IgA1 rather oriented the immunity towards an anti-inflammatory response. We have also highlighted both the regulation of IgA receptors expression by IgA and an IgA/CD8 cytotoxic T cells axis. We also designed a multivalent vaccine against Salmonella by coupling two antigens – SseB and OmpC – to secretory Ig. We pointed out solid specific humoral and cellular responses against both these antigens coupled to either IgA or IgM after intra-nasal immunization in mucosal but also systemic compartments. We have also demonstrated the possibility…

Advisors/Committee Members: Paul, Stéphane (thesis director), Corthésy, Blaise (thesis director).

Subjects/Keywords: IgA; Muqueuses; Vaccin; Salmonella; IgA; Mucous; Vaccine; Salmonella

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Gayet, R. (2018). Impact de la réponse IgA dans une nouvelle stratégie de vaccination muqueuse contre Salmonella et dans la régulation de la réponse adaptative : Impact of IgA response on both a novel mucosal vaccine strategy against Salmonella and on adaptive immune response regulation. (Doctoral Dissertation). Lyon. Retrieved from http://www.theses.fr/2018LYSES015

Chicago Manual of Style (16^th Edition):

Gayet, Rémi. “Impact de la réponse IgA dans une nouvelle stratégie de vaccination muqueuse contre Salmonella et dans la régulation de la réponse adaptative : Impact of IgA response on both a novel mucosal vaccine strategy against Salmonella and on adaptive immune response regulation.” 2018. Doctoral Dissertation, Lyon. Accessed February 26, 2021. http://www.theses.fr/2018LYSES015.

MLA Handbook (7^th Edition):

Gayet, Rémi. “Impact de la réponse IgA dans une nouvelle stratégie de vaccination muqueuse contre Salmonella et dans la régulation de la réponse adaptative : Impact of IgA response on both a novel mucosal vaccine strategy against Salmonella and on adaptive immune response regulation.” 2018. Web. 26 Feb 2021.

Vancouver:

Gayet R. Impact de la réponse IgA dans une nouvelle stratégie de vaccination muqueuse contre Salmonella et dans la régulation de la réponse adaptative : Impact of IgA response on both a novel mucosal vaccine strategy against Salmonella and on adaptive immune response regulation. [Internet] [Doctoral dissertation]. Lyon; 2018. [cited 2021 Feb 26]. Available from: http://www.theses.fr/2018LYSES015.

Council of Science Editors:

Gayet R. Impact de la réponse IgA dans une nouvelle stratégie de vaccination muqueuse contre Salmonella et dans la régulation de la réponse adaptative : Impact of IgA response on both a novel mucosal vaccine strategy against Salmonella and on adaptive immune response regulation. [Doctoral Dissertation]. Lyon; 2018. Available from: http://www.theses.fr/2018LYSES015

Leiden University

10. Oortwijn, B.D. Pathogenic role of (S)IgA in IgA nephropathy.

Degree: 2007, Leiden University

URL: http://hdl.handle.net/1887/8783

► Primary IgA nephropathy (IgAN) is the most common form of primary glomerulonephritis world wide and leads to end stage renal disease in 30-50% of patients.… (more)

Subjects/Keywords: Complement; IgA; IgA glycosylation; IgA receptors; Kidney disease; Secretory IgA; Complement; IgA; IgA glycosylation; IgA receptors; Kidney disease; Secretory IgA

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Oortwijn, B. D. (2007). Pathogenic role of (S)IgA in IgA nephropathy. (Doctoral Dissertation). Leiden University. Retrieved from http://hdl.handle.net/1887/8783

Chicago Manual of Style (16^th Edition):

Oortwijn, B D. “Pathogenic role of (S)IgA in IgA nephropathy.” 2007. Doctoral Dissertation, Leiden University. Accessed February 26, 2021. http://hdl.handle.net/1887/8783.

MLA Handbook (7^th Edition):

Oortwijn, B D. “Pathogenic role of (S)IgA in IgA nephropathy.” 2007. Web. 26 Feb 2021.

Vancouver:

Oortwijn BD. Pathogenic role of (S)IgA in IgA nephropathy. [Internet] [Doctoral dissertation]. Leiden University; 2007. [cited 2021 Feb 26]. Available from: http://hdl.handle.net/1887/8783.

Council of Science Editors:

Oortwijn BD. Pathogenic role of (S)IgA in IgA nephropathy. [Doctoral Dissertation]. Leiden University; 2007. Available from: http://hdl.handle.net/1887/8783

11. Diego Oliveira Miranda. Anticorpos IgA, IgE e IgG4 específicos a Dermatophagoides pteronyssinus e aos seus alérgenos principais, Der p 1 e Der p 2, em amostras de soro e saliva de crianças e adolescentes alérgicos e não-alérgicos.

Degree: 2009, Federal University of Uberlândia

URL: http://www.bdtd.ufu.br//tde_busca/arquivo.php?codArquivo=2605

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Allergic rhinitis (AR) is a global public health problem and it is gaining importance due to the rapid increase in its prevalence worldwide. House dust… (more)

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Allergic rhinitis (AR) is a global public health problem and it is gaining importance due to the rapid increase in its prevalence worldwide. House dust mites as Dermatophagoides spp. are the major sources of allergen sensitization in genetically predisposed subjects. This study aimed to evaluate serum and salivary IgA, IgE and IgG4 levels to Dermatophagoides pteronyssinus (Dpt) and its major allergens (Der p 1 and Der p 2) in allergic and non-allergic children and teenager. A total of 86 subjects were studied, from which 72 had AR and positive skin test to Dpt extract, and 14 were non-allergic subjects, with negative skin test to aeroallergens. Paired serum and saliva samples were collected from all subjects and analyzed by immunoenzymatic assays. Levels of serum IgE and serum or salivary IgG4 antibodies to Dpt, Der p 1, and Der p 2 were higher in allergic than non-allergic children and teenager (p <0.05). In contrast, levels of serum and salivary IgA antibodies to all allergens were higher in non-allergic than allergic children and teenager (p <0.05). It was noted that the ratio serum IgG4/IgE was lesser than 1.0 to all allergens and significantly lower in allergic than non-allergic children and teenager. It can be concluded that allergic children and teenager have high levels of serum IgE and IgG4 serum and salivary allergen-specific and low levels of serum and salivary IgA allergen-specific to Dpt, Der p 1 and Der p 2. Specific IgG4 antibodies are present in the serum and saliva from allergic children and teenager along with specific serum IgE, but IgE predominates in the serum of allergic children and teenager whereas IgG4 prevails in the serum of non-allergic children. Specific IgA appears to act as natural protective antibody since it predominates in the serum and saliva from non-allergic children and teenager.

Rinite alérgica (RA) é um problema de saúde pública global de suma importância, devido ao crescente aumento da sua prevalência em todo o mundo. Ácaros da poeira domiciliar como Dermatophagoides spp. constituem as principais fontes de sensibilização alergênica em indivíduos geneticamente predispostos. Este estudo teve como objetivo avaliar os níveis de anticorpos IgA, IgE e IgG4 específicos ao extrato total de Dermatophagoides pteronyssinus (Dpt) e aos seus alérgenos principais (Der p 1 e Der p 2) em amostras de soro e saliva de crianças e adolescentes alérgicos e não-alérgicos. Um total de 86 indivíduos foi estudado, dos quais 72 tinham RA e teste cutâneo positivo para o extrato Dpt, e 14 eram saudáveis não-alérgicos, com teste cutâneo negativo para aeroalérgenos. Amostras pareadas de soro e saliva foram coletadas de todos os indivíduos e analisadas por ensaios imunoenzimáticos. Os níveis de IgE sérica e de IgG4 sérica ou salivar específicas a Dpt, Der p 1 e Der p 2 foram maiores em crianças e adolescentes alérgicos que não-alérgicos (p <0,05). Ao contrário, os níveis de IgA sérica e salivar para todos os alérgenos foram maiores em indivíduos não-alérgicos em relação aos alérgicos (p <0,05). A razão…

Advisors/Committee Members: Janethe Deolina de Oliveira Pena, Deise Aparecida de Oliveira Silva, Nívea de Macedo Oliveira Morales, Ernesto Akio Taketomi, Gesmar Rodrigues Silva Segundo.

Subjects/Keywords: Rinite alérgica; Dermatophagoides pteronyssinus; IgA sérica; IgA salivar; IgE; IgG4; CIENCIAS DA SAUDE; Allergic rhinitis; salivary IgA

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Miranda, D. O. (2009). Anticorpos IgA, IgE e IgG4 específicos a Dermatophagoides pteronyssinus e aos seus alérgenos principais, Der p 1 e Der p 2, em amostras de soro e saliva de crianças e adolescentes alérgicos e não-alérgicos. (Thesis). Federal University of Uberlândia. Retrieved from http://www.bdtd.ufu.br//tde_busca/arquivo.php?codArquivo=2605

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Miranda, Diego Oliveira. “Anticorpos IgA, IgE e IgG4 específicos a Dermatophagoides pteronyssinus e aos seus alérgenos principais, Der p 1 e Der p 2, em amostras de soro e saliva de crianças e adolescentes alérgicos e não-alérgicos.” 2009. Thesis, Federal University of Uberlândia. Accessed February 26, 2021. http://www.bdtd.ufu.br//tde_busca/arquivo.php?codArquivo=2605.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Miranda, Diego Oliveira. “Anticorpos IgA, IgE e IgG4 específicos a Dermatophagoides pteronyssinus e aos seus alérgenos principais, Der p 1 e Der p 2, em amostras de soro e saliva de crianças e adolescentes alérgicos e não-alérgicos.” 2009. Web. 26 Feb 2021.

Vancouver:

Miranda DO. Anticorpos IgA, IgE e IgG4 específicos a Dermatophagoides pteronyssinus e aos seus alérgenos principais, Der p 1 e Der p 2, em amostras de soro e saliva de crianças e adolescentes alérgicos e não-alérgicos. [Internet] [Thesis]. Federal University of Uberlândia; 2009. [cited 2021 Feb 26]. Available from: http://www.bdtd.ufu.br//tde_busca/arquivo.php?codArquivo=2605.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Miranda DO. Anticorpos IgA, IgE e IgG4 específicos a Dermatophagoides pteronyssinus e aos seus alérgenos principais, Der p 1 e Der p 2, em amostras de soro e saliva de crianças e adolescentes alérgicos e não-alérgicos. [Thesis]. Federal University of Uberlândia; 2009. Available from: http://www.bdtd.ufu.br//tde_busca/arquivo.php?codArquivo=2605

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universitat Autònoma de Barcelona

12. Carnicer Cáceres, Clara. Utilidad clínica de biomarcadores de severidad y pronóstico de la nefropatía IgA en el adulto.

Degree: Departament de Medicina, 2017, Universitat Autònoma de Barcelona

URL: http://hdl.handle.net/10803/457577

► Urinary levels of molecules related to the activation of complement and to the local inflammatory environment inducing renal injury have been widely studied as potential… (more)

▼ Urinary levels of molecules related to the activation of complement and to the local inflammatory environment inducing renal injury have been widely studied as potential predictive markers of disease severity and prognosis in IgA nephropathy (IgAN). However, the role of these molecules as potential biomarkers remains poorly defined for several reasons. On one hand, the association between the urinary levels of some of these molecules and their respective mesangial deposits has not been adequately analyzed, and the contribution of molecules involved in the lectin pathway to complement activation in tubular cells is unknown. There are also no studies comparing the predictive ability of interstitial fibrosis among several urinary markers of renal injury progression. In addition, the data available are based on measurements obtained in spot-urine samples, and the accuracy of such measurements to estimate the 24h urine excretion has not been analyzed. Finally, the sources of variation subject to these measures have not been estimated, which are necessary to correctly interpret the results and define the methodological specifications. This thesis provides new data to the existing literature on these molecules through four observational studies performed in cohorts of patients with IgAN. The studies were focused on measurements of mannose binding lectin (MBL), C4d, C5b-9, properdin, interleukin 6 (IL-6), epidermal growth factor (EGF), monocyte chemoattractant protein 1 (MCP-1) and transforming growth factor β1 (TGFβ-1). The ability of urinary levels of complement related proteins to identify the local complement pathways activated in kidney biopsies was assessed, as well as the ability of urinary levels of cytokines and growth factors to predict the amount of interstitial fibrosis. The accuracy of spot-urine EGF measurements to predict the daily EGF excretion was also analyzed. Finally, sources of variation subject to urinary EGF measurements were estimated. This thesis concludes that urinary MBL contributes to the activation of complement by the lectin pathway in tubular cells and is associated with the severity of tubulointerstitial injury, and therefore could be considered as a potential marker of the severity of kidney injury in patients with IgAN. Urinary levels of MBL and C4d might be used in clinical practice as sensitive and specific biomarkers of the presence of their respective mesangial deposits. Results also show that urinary levels of EGF, MCP-1 and IL-6 improve the predictive ability of models including glomerular filtration rate (GFR) and age to estimate kidney interstitial fibrosis. The combination of MCP-1 and EGF levels, or MCP-1 and IL-6 levels, provide similar predictive power and appear to be the most appropriate to be applied in clinical practice. In addition, the spot EGF/creatinine ratio do not provide an adequate prediction of 24h excretion of EGF. In addition, the accuracy of the EGF/creatinine ratio to predict the 24h excretion depends on GFR and on the ensuing degree of interstitial… Advisors/Committee Members: [email protected] (authoremail), true (authoremailshow), Segarra Medrano, Alfons (director), Fonollosa Pla, Vicent (director), true (authorsendemail).

Subjects/Keywords: Nefropatia IgA; Nefropatía IgA; IgA nephropaty; Biomarcadors; Biomarcadores; Biomarkers; Fibrosi; Fibrosis; Ciències de la Salut; 616

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Carnicer Cáceres, C. (2017). Utilidad clínica de biomarcadores de severidad y pronóstico de la nefropatía IgA en el adulto. (Thesis). Universitat Autònoma de Barcelona. Retrieved from http://hdl.handle.net/10803/457577

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Carnicer Cáceres, Clara. “Utilidad clínica de biomarcadores de severidad y pronóstico de la nefropatía IgA en el adulto.” 2017. Thesis, Universitat Autònoma de Barcelona. Accessed February 26, 2021. http://hdl.handle.net/10803/457577.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Carnicer Cáceres, Clara. “Utilidad clínica de biomarcadores de severidad y pronóstico de la nefropatía IgA en el adulto.” 2017. Web. 26 Feb 2021.

Vancouver:

Carnicer Cáceres C. Utilidad clínica de biomarcadores de severidad y pronóstico de la nefropatía IgA en el adulto. [Internet] [Thesis]. Universitat Autònoma de Barcelona; 2017. [cited 2021 Feb 26]. Available from: http://hdl.handle.net/10803/457577.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Carnicer Cáceres C. Utilidad clínica de biomarcadores de severidad y pronóstico de la nefropatía IgA en el adulto. [Thesis]. Universitat Autònoma de Barcelona; 2017. Available from: http://hdl.handle.net/10803/457577

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

13. Felipe Lynch de Moraes, Luiz. Toxoplasmose ocular: níveis de IgA secretora específica na lágrima de pacientes na fase ativa e inativa da doença .

Degree: 2009, Universidade Federal de Pernambuco

URL: http://repositorio.ufpe.br/handle/123456789/7225

► Introdução: A toxoplasmose ocular é provocada pelo Toxoplasma gondii que causa uveíte recorrente, cujo diagnóstico clínico pode se confundir com outras uveítes. Estudos mostram que… (more)

Subjects/Keywords: Uveíte; Toxoplasmose ocular; IgA secretora; Lágrima

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Felipe Lynch de Moraes, L. (2009). Toxoplasmose ocular: níveis de IgA secretora específica na lágrima de pacientes na fase ativa e inativa da doença . (Thesis). Universidade Federal de Pernambuco. Retrieved from http://repositorio.ufpe.br/handle/123456789/7225

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Felipe Lynch de Moraes, Luiz. “Toxoplasmose ocular: níveis de IgA secretora específica na lágrima de pacientes na fase ativa e inativa da doença .” 2009. Thesis, Universidade Federal de Pernambuco. Accessed February 26, 2021. http://repositorio.ufpe.br/handle/123456789/7225.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Felipe Lynch de Moraes, Luiz. “Toxoplasmose ocular: níveis de IgA secretora específica na lágrima de pacientes na fase ativa e inativa da doença .” 2009. Web. 26 Feb 2021.

Vancouver:

Felipe Lynch de Moraes L. Toxoplasmose ocular: níveis de IgA secretora específica na lágrima de pacientes na fase ativa e inativa da doença . [Internet] [Thesis]. Universidade Federal de Pernambuco; 2009. [cited 2021 Feb 26]. Available from: http://repositorio.ufpe.br/handle/123456789/7225.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Felipe Lynch de Moraes L. Toxoplasmose ocular: níveis de IgA secretora específica na lágrima de pacientes na fase ativa e inativa da doença . [Thesis]. Universidade Federal de Pernambuco; 2009. Available from: http://repositorio.ufpe.br/handle/123456789/7225

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Penn State University

14. Zhou, Hanbing. Comparison of retinoic acid (oral and subcutaneous) and vitamin A (oral) effects on immune response in vitamin A deficient mice.

Degree: 2012, Penn State University

URL: https://submit-etda.libraries.psu.edu/catalog/16209

► min A deficiency is widely present in developing countries, affecting human’s health especially children with high morbidity and mortality. Vitamin A deficient (VAD) animals have… (more)

▼ min A deficiency is widely present in developing countries, affecting human’s health especially children with high morbidity and mortality. Vitamin A deficient (VAD) animals have the impaired immunity to many infections. In vaccines models VAD animals show depressed antibody and cytokine production, reduced cytotoxic T lymphocyte activity and impaired T lymphocytes trafficking to the gastrointestinal tract. Vitamin A (VA) supplements have been shown to play an important role in reducing mortality, improving recovery from measles, and decreasing the severity of malaria infection in children. Oral VA supplementation as well as retinoic acid (RA) administration restores the impaired mucosal immune response and vaccine efficiency in VAD mice model. RA subcutaneous (sc) injection has been shown to induce the homing of T and B cells to the gut and to stimulate immunoglobulin A (IgA)+ plasma cells generation. Ovalbumin (OVA) is a widely used oral antigen for immune and oral tolerance studies. Tetanus toxoid (TT) is a protein antigen used as a vaccine against tetanus, to prevent the infection of Clostridium tetani. Cholera Toxin Subunit B (CTB), as a possible nontoxic adjuvant shown in animal studies, was mixed with OVA as a mucosal adjuvant in my project. Here, we compared the different supplementation (VA orally versus RA orally or by subcutaneous injection) in the VAD mice model, with OVA and TT as antigens delivered through oral challenge or subcutaneous injection. RA sc supplementation enhanced the plasma and fecal OVA specific IgA and TT specific IgG production in secondary immune response and plasma OVA specific IgA after third immunization. RA oral supplementation only showed its effect on increasing plasma OVA specific IgA response after the third immunization. Whereas VA supplementation did not affect the OVA mucosal immunization, it only strengthens TT specific IgG response after the secondary immunization. From these results, RA, especially the RA sc injection demonstrates stronger effects on mucosal immune response than VA supplementation. Advisors/Committee Members: A Catharine Ross, Thesis Advisor/Co-Advisor, Margherita Teresa Anna Cantorna, Thesis Advisor/Co-Advisor, Na Xiong, Thesis Advisor/Co-Advisor.

Subjects/Keywords: vitamin A; retinoic acid; mucosal immunity; IgA

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Zhou, H. (2012). Comparison of retinoic acid (oral and subcutaneous) and vitamin A (oral) effects on immune response in vitamin A deficient mice. (Thesis). Penn State University. Retrieved from https://submit-etda.libraries.psu.edu/catalog/16209

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Zhou, Hanbing. “Comparison of retinoic acid (oral and subcutaneous) and vitamin A (oral) effects on immune response in vitamin A deficient mice.” 2012. Thesis, Penn State University. Accessed February 26, 2021. https://submit-etda.libraries.psu.edu/catalog/16209.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Zhou, Hanbing. “Comparison of retinoic acid (oral and subcutaneous) and vitamin A (oral) effects on immune response in vitamin A deficient mice.” 2012. Web. 26 Feb 2021.

Vancouver:

Zhou H. Comparison of retinoic acid (oral and subcutaneous) and vitamin A (oral) effects on immune response in vitamin A deficient mice. [Internet] [Thesis]. Penn State University; 2012. [cited 2021 Feb 26]. Available from: https://submit-etda.libraries.psu.edu/catalog/16209.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Zhou H. Comparison of retinoic acid (oral and subcutaneous) and vitamin A (oral) effects on immune response in vitamin A deficient mice. [Thesis]. Penn State University; 2012. Available from: https://submit-etda.libraries.psu.edu/catalog/16209

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

AUT University

15. Gibson, Chloe. Dose response effects of caffeine ingestion on salivary immunoglobulin A following high-intensity exercise .

Degree: 2012, AUT University

URL: http://hdl.handle.net/10292/4682

► Many athletes consume caffeine for its known ergogenic properties, with doses between 2-13 mg·kg-1 body mass (BM) being shown to enhance performance. While the range… (more)

▼ Many athletes consume caffeine for its known ergogenic properties, with doses between 2-13 mg·kg-1 body mass (BM) being shown to enhance performance. While the range of ergogenic doses is large, caffeine has been reported to have no dose-response effect. In addition, large doses have been associated with negative side effects and have also been reported to have immunosuppressive effects, which have been attributed to increases in adrenaline. However, despite the prevalence of caffeine consumption in both athletic and non-athletic populations, and research showing the potential for caffeine to suppress some markers of immune function, little research has examined the effects of caffeine ingestion on immune function in response to exercise in humans. Therefore the aim of this thesis was to investigate the influence of several doses of caffeine (typically used in training and competition situations) on the saliva IgA response to prolonged high-intensity exercise. In a double-blind repeated-measures crossover design, 12 endurance-trained males ran for 70 min on a treadmill at 80% V̇O2peak, 60 min after ingesting 2, 4, 6 or 8 mg·kg-1 body mass (BM) of anhydrous caffeine or placebo (cornflour) (PLA, 2CAF, 4CAF, 6CAF or 8CAF). Un-stimulated whole saliva samples were obtained before supplementation, pre-exercise, mid-exercise, immediately post-exercise and 1 h post-exercise. Participants were habituated caffeine users and abstained from caffeine 60 h prior to trials. Trials were conducted 7 days apart at the same time of day. Saliva caffeine concentration was significantly higher in all caffeine trials than placebo at pre-exercise, mid-exercise, immediately post-exercise and 1 h post-exercise (P < 0.01). Saliva IgA concentration, secretion rate and saliva flow rate remained unchanged following placebo and caffeine trials. In contrast saliva α-amylase activity was higher in 6CAF, 4CAF and 2CAF trials when compared to PLA and 8CAF (P < 0.05). In conclusion, the findings of this thesis demonstrate that while ingesting caffeine doses of 2-8 mg·kg-1BM has neither a positive or negative affect on saliva IgA or flow rate, it does appear to increase α-amylase activity. While the biological significance of these findings in terms of caffeine’s potential to modify an individual’s susceptibility to infection following prolonged high-intensity exercise is unknown, it is suggested that athletes consume the lowest beneficial dose in order to avoid potential side effects observed with higher doses of caffeine. Advisors/Committee Members: Fletcher, Deborah (advisor), Kilding, Andrew (advisor).

Subjects/Keywords: Saliva; IgA; Immune; Methylxanthine; Treadmill; Exercise

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Gibson, C. (2012). Dose response effects of caffeine ingestion on salivary immunoglobulin A following high-intensity exercise . (Thesis). AUT University. Retrieved from http://hdl.handle.net/10292/4682

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Gibson, Chloe. “Dose response effects of caffeine ingestion on salivary immunoglobulin A following high-intensity exercise .” 2012. Thesis, AUT University. Accessed February 26, 2021. http://hdl.handle.net/10292/4682.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Gibson, Chloe. “Dose response effects of caffeine ingestion on salivary immunoglobulin A following high-intensity exercise .” 2012. Web. 26 Feb 2021.

Vancouver:

Gibson C. Dose response effects of caffeine ingestion on salivary immunoglobulin A following high-intensity exercise . [Internet] [Thesis]. AUT University; 2012. [cited 2021 Feb 26]. Available from: http://hdl.handle.net/10292/4682.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Gibson C. Dose response effects of caffeine ingestion on salivary immunoglobulin A following high-intensity exercise . [Thesis]. AUT University; 2012. Available from: http://hdl.handle.net/10292/4682

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Boston University

16. Kadasia, Kadryn. The functional role of naturally occurring antibodies against HIV-1 in human genital mucosa.

Degree: PhD, Molecular and Translational Medicine, 2018, Boston University

URL: http://hdl.handle.net/2144/29991

► Sexual transmission of the Human Immunodeficiency Virus Type 1 (HIV-1) accounts for the majority of newly acquired infections. Vaccination efforts have induced only modest protection… (more)

▼ Sexual transmission of the Human Immunodeficiency Virus Type 1 (HIV-1) accounts for the majority of newly acquired infections. Vaccination efforts have induced only modest protection in HIV clinical trials. HIV-1 induces a robust local immune response in genital mucosa of exposed individuals. Understanding the function of naturally occurring antibodies against HIV-1 in genital mucosa, the primary site of transmission, might be instrumental to improving vaccines and antibody-based microbicides. This study focused on HIV-specific antibody responses in the male genital tract (MGT), which is underexplored. We characterized antibody subclasses and specificities in genital tract secretions (seminal plasma, urethral secretions) and blood from a cohort of HIV-1-infected men to determine the origin and distinct nature of antibodies in the MGT. We detected similar HIV-1 IgG titers and specificities in all three body fluids, indicating that MGT IgG likely originates from blood. In contrast, gp41-specific IgA was restricted to genital secretions suggesting a local niche of IgA antibody production. Genital secretions from a subset of individuals neutralized cell-free HIV-1 and blocked cell-to-cell HIV-1 transmission. Statistically, these functions correlated positively with gp41 IgA titers. HIV-specific IgA monoclonal antibodies were also effective in these assays. To explore cell-dependent activities of HIV-specific antibodies in genital mucosa we surveyed Fc receptor expression in mucosal epithelial tissue. The IgG-engaging neonatal Fc receptor (FcRn), the IgA receptor FcαRI and the high-affinity intracellular Fc receptor TRIM21 were detected by immunohistochemistry and western blots. In stratified squamous epithelia (foreskin, vagina) FcRn+ epithelial cells were detected primarily in the basal layer, FcαRI+ epithelial cells in suprabasal layers and TRIM21 throughout. Deposits of immunoglobulins in the stratified squamous epithelium colocalized with FcRn, FcαRI and TRIM21. Our findings indicate that the MGT is capable of expressing a local anti-HIV IgA response to achieve antiviral defense through antibody neutralization and cell-dependent functions involving classical immune effector cells and epithelial cells. Advisors/Committee Members: Anderson, Deborah J (advisor), Snyder-Cappione, Jennifer (advisor).

Subjects/Keywords: Immunology; Genital tract; HIV; IgA; Reproductive biology

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Kadasia, K. (2018). The functional role of naturally occurring antibodies against HIV-1 in human genital mucosa. (Doctoral Dissertation). Boston University. Retrieved from http://hdl.handle.net/2144/29991

Chicago Manual of Style (16^th Edition):

Kadasia, Kadryn. “The functional role of naturally occurring antibodies against HIV-1 in human genital mucosa.” 2018. Doctoral Dissertation, Boston University. Accessed February 26, 2021. http://hdl.handle.net/2144/29991.

MLA Handbook (7^th Edition):

Kadasia, Kadryn. “The functional role of naturally occurring antibodies against HIV-1 in human genital mucosa.” 2018. Web. 26 Feb 2021.

Vancouver:

Kadasia K. The functional role of naturally occurring antibodies against HIV-1 in human genital mucosa. [Internet] [Doctoral dissertation]. Boston University; 2018. [cited 2021 Feb 26]. Available from: http://hdl.handle.net/2144/29991.

Council of Science Editors:

Kadasia K. The functional role of naturally occurring antibodies against HIV-1 in human genital mucosa. [Doctoral Dissertation]. Boston University; 2018. Available from: http://hdl.handle.net/2144/29991

University of Windsor

17. Kondepudi, Padma Priya. Robot Path Planning with IGA-MMAS and MMAS-IGA.

Degree: MS, Computer Science, 2019, University of Windsor

URL: https://scholar.uwindsor.ca/etd/8144

► Path Planning of mobile robots is one of the essential tasks in robotic research and studies with intelligent technologies. It helps in determining the path… (more)

Subjects/Keywords: Grid path planning; IGA; Path planning

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APA (6^th Edition):

Kondepudi, P. P. (2019). Robot Path Planning with IGA-MMAS and MMAS-IGA. (Masters Thesis). University of Windsor. Retrieved from https://scholar.uwindsor.ca/etd/8144

Chicago Manual of Style (16^th Edition):

Kondepudi, Padma Priya. “Robot Path Planning with IGA-MMAS and MMAS-IGA.” 2019. Masters Thesis, University of Windsor. Accessed February 26, 2021. https://scholar.uwindsor.ca/etd/8144.

MLA Handbook (7^th Edition):

Kondepudi, Padma Priya. “Robot Path Planning with IGA-MMAS and MMAS-IGA.” 2019. Web. 26 Feb 2021.

Vancouver:

Kondepudi PP. Robot Path Planning with IGA-MMAS and MMAS-IGA. [Internet] [Masters thesis]. University of Windsor; 2019. [cited 2021 Feb 26]. Available from: https://scholar.uwindsor.ca/etd/8144.

Council of Science Editors:

Kondepudi PP. Robot Path Planning with IGA-MMAS and MMAS-IGA. [Masters Thesis]. University of Windsor; 2019. Available from: https://scholar.uwindsor.ca/etd/8144

18. Mohey, Hesham. Le risque rénal absolu (RRA) de dialyse ou décès chez les patients adultes avec néphropathie à IgA primaire (NIgA) : étude d’une cohorte prospective de néphropathie à IgA recrutée à Saint-Etienne (IGAN -STET-CO) : Predicting the risk for dialysis or death in IgA nephropathy.

Degree: Docteur es, Recherche clinique innovation technologique santé publique, 2010, Saint-Etienne

URL: http://www.theses.fr/2010STET010T

► La NIgA primaire est la plus fréquente des glomérulonéphrites. Elle représente, selon l’origine géographique et ethnique des populations, 10 à 40% des glomérulonéphrites primitives. Le… (more)

▼ La NIgA primaire est la plus fréquente des glomérulonéphrites. Elle représente, selon l’origine géographique et ethnique des populations, 10 à 40% des glomérulonéphrites primitives. Le diagnostic de NIgA est fait nécessairement sur la ponction biopsie rénale (PBR) en immunoﬂuorescence. La grande difficulté dans cette maladie se trouve dans la prédiction au moment du diagnostic par les facteurs pronostiques de l’évolution vers l'insuffisance rénale chronique terminale à 10 et 20 ans après le début de la maladie. L’hypertension artérielle, la protéinurie ≥l g/24 h et la sévérité des lésions histologiques sur la biopsie rénale sont les facteurs de risque majeurs qui permettent la prédiction initiale. Objectifs de l’étude : conﬁrmer et valider dans notre cohorte de NIgA les 3 facteurs de risque (FdR) comme facteurs significatifs et indépendants prédictifs d’une évolution ultérieure vers la Dialyse ou le Décès (avant dialyse) et utiliser ces 3 FdR pour développer un modèle simple de Risque Rénal Absolu (RRA) dont le score évalué au moment du diagnostic permettrait une prédiction du devenir à long terme (10 et 20 ans). Notre cohorte de patients (332) avec NIgA a été recrutée par le Service de Néphrologie, Dialyse, et Transplantation Rénale du CHU de Saint Etienne à l’Hôpital Nord (IGAN-STET-CO). La cohorte est prospective et inclut tous les patients avec diagnostic de Néphropathie à IgA primaire dont la biopsie rénale diagnostique a été réalisée entre le 1er janvier 1990 et le 31 décembre 1999. Le diagnostic histologique de NIgA est défini par la présence de dépôts mésangiaux d’IgA, d’intensité au moins 1+ comme immunoglobuline dominante ou codominante en immunofluorescence. L’intervalle de temps entre le début la maladie et la PBR diagnostique a été de : moyenne (déviation standard, DS) = 5.7 (8.5) ans et médiane (extrêmes) = 2.5 (0.1-46.9) ans. La durée totale d’exposition au risque principal entre le début de NIgA et le dernier recul ou le l’évènement principal était: moyenne (DS) = 12.9 (9.5) ans et médiane (extrêmes) = 11.3 (0.l-56.0) ans; chez 44 patients cette durée d’exposition était supérieure à 20 ans (l3.3%). La progression de la NIgA a été basée sur l’apparition de deux évènements : l’évènement principal (primary end-point) était la dialyse (Di; correspondant à la mort rénale avec un DFG de stade V autour de 8 ml/mn/1.73m2S) ou le décès du patient (De; s’il survenait avant le début de la dialyse), et représenté par Di/De ou plus simplement par D/D; l’évènement secondaire (secondary end-point) était la survenue d’un DFGe<60 ml/mn/1.73m2S marquant le début de l’IRC et correspondant à l’entrée dans le stade III de la maladie rénale chronique (MRC-3+). Les facteurs de risque majeurs étudiés dans cette étude sont l’hypertension artérielle (supérieure à 140/90 mmHg), la protéinurie (≥1g/24 h), et le score optique global (GOS ≥8). Le risque rénal absolu (RRA) de dialyse/décès (D/D) a été calculé à partir de ces trois facteurs simplifiés et dichotomiques après avoir confirmé leur caractère indépendant (les uns des… Advisors/Committee Members: Béthoux, François (thesis director), Mariat, Christophe (thesis director).

Subjects/Keywords: IgA néphropathie; Risque rénal absolu; Dialyse; Maladie auto-immune; Protéinurie; Maladie rénale chronique; IgA

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Mohey, H. (2010). Le risque rénal absolu (RRA) de dialyse ou décès chez les patients adultes avec néphropathie à IgA primaire (NIgA) : étude d’une cohorte prospective de néphropathie à IgA recrutée à Saint-Etienne (IGAN -STET-CO) : Predicting the risk for dialysis or death in IgA nephropathy. (Doctoral Dissertation). Saint-Etienne. Retrieved from http://www.theses.fr/2010STET010T

Chicago Manual of Style (16^th Edition):

Mohey, Hesham. “Le risque rénal absolu (RRA) de dialyse ou décès chez les patients adultes avec néphropathie à IgA primaire (NIgA) : étude d’une cohorte prospective de néphropathie à IgA recrutée à Saint-Etienne (IGAN -STET-CO) : Predicting the risk for dialysis or death in IgA nephropathy.” 2010. Doctoral Dissertation, Saint-Etienne. Accessed February 26, 2021. http://www.theses.fr/2010STET010T.

MLA Handbook (7^th Edition):

Mohey, Hesham. “Le risque rénal absolu (RRA) de dialyse ou décès chez les patients adultes avec néphropathie à IgA primaire (NIgA) : étude d’une cohorte prospective de néphropathie à IgA recrutée à Saint-Etienne (IGAN -STET-CO) : Predicting the risk for dialysis or death in IgA nephropathy.” 2010. Web. 26 Feb 2021.

Vancouver:

Mohey H. Le risque rénal absolu (RRA) de dialyse ou décès chez les patients adultes avec néphropathie à IgA primaire (NIgA) : étude d’une cohorte prospective de néphropathie à IgA recrutée à Saint-Etienne (IGAN -STET-CO) : Predicting the risk for dialysis or death in IgA nephropathy. [Internet] [Doctoral dissertation]. Saint-Etienne; 2010. [cited 2021 Feb 26]. Available from: http://www.theses.fr/2010STET010T.

Council of Science Editors:

Mohey H. Le risque rénal absolu (RRA) de dialyse ou décès chez les patients adultes avec néphropathie à IgA primaire (NIgA) : étude d’une cohorte prospective de néphropathie à IgA recrutée à Saint-Etienne (IGAN -STET-CO) : Predicting the risk for dialysis or death in IgA nephropathy. [Doctoral Dissertation]. Saint-Etienne; 2010. Available from: http://www.theses.fr/2010STET010T

19. Gerolymos, Miltiadis. Θεραπευτική αντιμετώπιση ασθενών με IgA νεφροπάθεια με βάση κλασικούς και νεότερους δείκτες εξέλιξης της νόσου.

Degree: 2014, University of Patras; Πανεπιστήμιο Πατρών

URL: http://hdl.handle.net/10442/hedi/34828

► IgA nephropathy represents a common glomerular disease treated by various therapeutic regimens. In the first part of the current thesis, the effect of different therapeutic… (more)

▼ IgA nephropathy represents a common glomerular disease treated by various therapeutic regimens. In the first part of the current thesis, the effect of different therapeutic regimens based on the severity of clinical and histological involvement, in the clinical outcome of patients with IgA nephropathy over a follow-up period of 5 years was estimated. Fifty patients were included in the study and were divided in four groups. Patients with normal renal function and proteinuria <1g/24h received no treatment (Group A, n=6). Patients with normal renal function, proteinuria >1g/24h and mild to moderate histological lesions received angiotensin converting enzyme inhibitors (ACEi) and corticosteroids (Group B, n=23). Patients with baseline serum creatinine (Scr) <2.5mg/dl, proteinuria >3.5g/24h and severe histological lesions received ACEi, corticosteroids and other immunosuppressive drugs (Group C, n=18). Patients with Scr >2.5mg/dl, glomerulosclerosis and tubulointerstitial fibrosis received ACEi and fish oil (Group D, n=3). Doubling of baseline Scr was observed in 9 of 50 patients (18%), 2 from group B (8.7%), 5 from group C (27.7%) and 2 from group D (66.7%). Out of 7 (14%) who reached ESRD, 1was from group B (4.3%), 4 from group C (22%) and 2 from group D (66.7%). Reduction of proteinuria was observed in all patients from group B and in 15 from group C (83.3%). Adverse reactions occurred in 3 (7.3%) patients treated with immunosupressive drugs. The choice of therapeutic regimen used in the treatment of patients with IgA nephropathy could be based on the severity of clinical and histological involvement in order to achieve the maximun effect with less adverse reactions.In the second part potential early markers for progression of renal injury in both kidney tissue and urine of patients were studied. Genomic and proteomic studies suggest that transgelin represents a protein that may be involved in renal injury. Transgelin was identified in biopsy sections of 67 patients by immunohistochemistry and immunofluorescence. Its distribution was compared to that of α-smooth muscle actin (α-SMA), a marker of myofibroblast activation in the kidney. Transgelin and α-SMA expression was identified within glomeruli and interstitium. In patients with IgA nephropathy and focal segmental glomerulosclerosis, glomerular expression of transgelin was higher than that of α-SMA. The extent of transgelin immunostaining was related to mesangial proliferation (p=0.034), glomerular sclerosis (p=0.035), interstitial fibrosis (p=0.047) and to the clinical course (p=0.009). Colocalization studies showed that in some areas of kidney tissue both proteins were expressed with comparable intensity, whereas in other areas expression of either transgelin or α-SMA was predominant. Strong transgelin expression was observed in renal tissue of patients with glomerulonephritis. The observed differences in the pattern of transgelin and α-SMA expression suggest that either different subpopulation of myofibroblasts exist, or that these proteins are activated at…

Subjects/Keywords: IgA νεφροπάθεια; Τρανσγελίνη; Κυτταροκίνες; Προγνωστικοί δείκτες; IgA nephropathy; Transgelin; Cytokines; Predictor factors

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Gerolymos, M. (2014). Θεραπευτική αντιμετώπιση ασθενών με IgA νεφροπάθεια με βάση κλασικούς και νεότερους δείκτες εξέλιξης της νόσου. (Thesis). University of Patras; Πανεπιστήμιο Πατρών. Retrieved from http://hdl.handle.net/10442/hedi/34828

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Gerolymos, Miltiadis. “Θεραπευτική αντιμετώπιση ασθενών με IgA νεφροπάθεια με βάση κλασικούς και νεότερους δείκτες εξέλιξης της νόσου.” 2014. Thesis, University of Patras; Πανεπιστήμιο Πατρών. Accessed February 26, 2021. http://hdl.handle.net/10442/hedi/34828.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Gerolymos, Miltiadis. “Θεραπευτική αντιμετώπιση ασθενών με IgA νεφροπάθεια με βάση κλασικούς και νεότερους δείκτες εξέλιξης της νόσου.” 2014. Web. 26 Feb 2021.

Vancouver:

Gerolymos M. Θεραπευτική αντιμετώπιση ασθενών με IgA νεφροπάθεια με βάση κλασικούς και νεότερους δείκτες εξέλιξης της νόσου. [Internet] [Thesis]. University of Patras; Πανεπιστήμιο Πατρών; 2014. [cited 2021 Feb 26]. Available from: http://hdl.handle.net/10442/hedi/34828.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Gerolymos M. Θεραπευτική αντιμετώπιση ασθενών με IgA νεφροπάθεια με βάση κλασικούς και νεότερους δείκτες εξέλιξης της νόσου. [Thesis]. University of Patras; Πανεπιστήμιο Πατρών; 2014. Available from: http://hdl.handle.net/10442/hedi/34828

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

20. Abbad, Lilia. Rôle de la voie transglutaminase 2/MMP-9 dans la pathogénèse de la néphropathie à IgA et nouvelles approches thérapeutiques : Role of transglutaminase 2 and MMP-9 in the pathogenesis of IgA nephropathy and new therapeutic approaches.

Degree: Docteur es, Sciences de la vie et de la santé, 2018, Sorbonne Paris Cité

URL: http://www.theses.fr/2018USPCC118

►

La néphropathie à IgA (IgAN), est une maladie glomérulaire chronique primitive et principale cause d'insuffisance rénale dans le monde. Les causes et les facteurs aboutissant… (more)

▼

La néphropathie à IgA (IgAN), est une maladie glomérulaire chronique primitive et principale cause d'insuffisance rénale dans le monde. Les causes et les facteurs aboutissant aux dépôts des complexes d'IgA1 sont inconnus. La forme soluble du récepteur (CD89s) complexée aux IgA joue un rôle clé dans la pathogenèse de cette maladie. Actuellement, aucun traitement spécifique n'est disponible et les options thérapeutiques sont limitées. La compréhension des mécanismes de la formation de ces complexes permettra d'envisager de nouvelles approches thérapeutiques. Dans cette perspective la première partie de cette thèse, met en évidence l'implication d'une protéine essentielle au développement de la N-IgA, la TG2, dans la régulation du clivage du CD89, et cela par la répression de la sérine phosphatase PP2A et l'activation de la métalloprotéase matricielle MMP-9. Dans les monocytes de patients l'expression diminuée de PP2A est associée à une tendance à l'augmentation de TG2, et inversement corrélée avec l'augmentation des complexes IgA1-CD89s. Afin de cibler ces complexes pathogéniques, un essai préclinique a été réalisé avec une protéase recombinante d'origine bactérienne clivant spécifiquement les IgA1 (IgA1-P). Les résultats ont formellement démontré la spécificité et l'efficacité de la protéase dans la réduction des complexes circulants et des dépôts d'IgA1 dans le modèle humanisé de N-IgA, associée à une diminution des marqueurs de l'inflammation et de l'hématurie. Les résultats ont mis en évidence le rôle de la dérégulation de l'axe TG2-PP2A-MMP-9 dans la formation des complexes IgA1-CD89s lors de la N-IgA, ainsi que l'efficacité de l'IgA1-P à éliminer ces complexes. Ces travaux suggèrent en plus du potentiel thérapeutique promoteur de l'IgA1-P, trois éventuelles cibles thérapeutiques envisageables pour la N-IgA.

IgA nephropathy (IgAN) is a mesangial proliferative primary glomerulonephritis and a major cause of end-stage renal disease. Causes and factors leading to mesangial IgA1 deposition are unknown. The soluble form of the receptor (sCD89) complexed with IgA plays a key role in the pathogenesis of the disease. There is currently no specific treatment available and the therapeutic options are limited. A better comprehension of the mechanisms regulating the formation of IgA1-sCD89 complexes will unveil new strategies for targeted therapies. In this perspective, the first part of this thesis highlights the implication of the transglutaminase 2 (TG2), a protein essential for the development of IgAN, in the regulation of CD89 cleavage, in a mechanism involving the repression of the serine phosphatase PP2A and the activation of the matrix metalloproteinase MMP-9. While a trend towards TG2 increase is observed, PP2A expression is reduced in monocytes obtained from IgAN patients compared to controls, and inversely correlates with the levels of circulating hIgA1-sCD89 complexes. In order to target these pathogenic complexes, a preclinical assay has been performed with a recombinant protease, a bacterial protein that…

Advisors/Committee Members: Vrtovsnik, François (thesis director), Berthelot, Laureline (thesis director).

Subjects/Keywords: Immunoglobuline A (igA); Transglutaminase 2; Néphropathies; Immunoglobulin A (iga); Transglutaminase 2; Kidney diseases

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Abbad, L. (2018). Rôle de la voie transglutaminase 2/MMP-9 dans la pathogénèse de la néphropathie à IgA et nouvelles approches thérapeutiques : Role of transglutaminase 2 and MMP-9 in the pathogenesis of IgA nephropathy and new therapeutic approaches. (Doctoral Dissertation). Sorbonne Paris Cité. Retrieved from http://www.theses.fr/2018USPCC118

Chicago Manual of Style (16^th Edition):

Abbad, Lilia. “Rôle de la voie transglutaminase 2/MMP-9 dans la pathogénèse de la néphropathie à IgA et nouvelles approches thérapeutiques : Role of transglutaminase 2 and MMP-9 in the pathogenesis of IgA nephropathy and new therapeutic approaches.” 2018. Doctoral Dissertation, Sorbonne Paris Cité. Accessed February 26, 2021. http://www.theses.fr/2018USPCC118.

MLA Handbook (7^th Edition):

Abbad, Lilia. “Rôle de la voie transglutaminase 2/MMP-9 dans la pathogénèse de la néphropathie à IgA et nouvelles approches thérapeutiques : Role of transglutaminase 2 and MMP-9 in the pathogenesis of IgA nephropathy and new therapeutic approaches.” 2018. Web. 26 Feb 2021.

Vancouver:

Abbad L. Rôle de la voie transglutaminase 2/MMP-9 dans la pathogénèse de la néphropathie à IgA et nouvelles approches thérapeutiques : Role of transglutaminase 2 and MMP-9 in the pathogenesis of IgA nephropathy and new therapeutic approaches. [Internet] [Doctoral dissertation]. Sorbonne Paris Cité; 2018. [cited 2021 Feb 26]. Available from: http://www.theses.fr/2018USPCC118.

Council of Science Editors:

Abbad L. Rôle de la voie transglutaminase 2/MMP-9 dans la pathogénèse de la néphropathie à IgA et nouvelles approches thérapeutiques : Role of transglutaminase 2 and MMP-9 in the pathogenesis of IgA nephropathy and new therapeutic approaches. [Doctoral Dissertation]. Sorbonne Paris Cité; 2018. Available from: http://www.theses.fr/2018USPCC118

Universitat Autònoma de Barcelona

21. Graterol Torres, Fredzzia Amada. Aplicación de la proteómica en el estudio de factores pronósticos de la nefropatia IgA.

Degree: Departament de Medicina, 2019, Universitat Autònoma de Barcelona

URL: http://hdl.handle.net/10803/669849

► IgA nephropathy (IgAN) is the most common primary glomerulonephritis worldwide, characterized by wide clinical variability, ranging from a benign to rapidly progressive renal failure. The… (more)

▼ IgA nephropathy (IgAN) is the most common primary glomerulonephritis worldwide, characterized by wide clinical variability, ranging from a benign to rapidly progressive renal failure. The diagnosis of IgAN is made by renal biopsy, being an invasive procedure with potential complications. Moreover, the majority of patients with IgAN have a progressive disease, with 40% of cases reaching end stage renal disease within 20 years after diagnosis. It has been described poor risk factors similar to others renal diseases, for this reason its necessary to search specific new biomarkers to help the nephrologist in the treatment decision. These molecules would have to be able to identify a group of patients with a poor prognosis, with a higher risk of progression to end stage kidney disease (ESKD) in which the benefit of early and aggressive treatment is clear. Proteomics approachs represents an accessible and reproducible tool that allows us identify in blood and urine peptides related to biological processes. In the present study, proteomic techniques have been applied through mass spectrometry to identify a profile of peptides in blood, plasma and urine, associated with clinical, biochemical and histological parameters in a cohort of patients with primary IgAN and IgAN with C4d deposits. As a result, we found C4a, bradykinin, A1AT and B2 microglobulin serum peptides, and A1AT and UMOD urinary peptides differentiated patients with IgAN from control subjects; and were associated with worse renal outcomes: double of creatinine, glomerulosclerosis and tubulointerstitial damage/tubular atrophy. In addition, in the IgAN with C4d deposits study, we found higher urinary and plasma levels of eptides A1AT and C4a in IgAN C4d positive patients than C4d negative. In addition, histological lesions glomerulosclerosis and endocapillary hypercellularity lesions were significantly associated with IgAN C4d positive group, a worse renal prognosis group. A potential cut-off was defined that discriminated correctly between groups. We propose the use of proteomic techniques in the search for markers of poor renal prognosis in IgAN can help to establish an early diagnosis and identify a group of patients with a poor renal evolution and tributary of more aggressive therapies. Advisors/Committee Members: [email protected] (authoremail), true (authoremailshow), Ibernón Vilaró, Meritxell (director), Bonal Bastons, Jordi (director), Monreal Bosch, Manuel (tutor).

Subjects/Keywords: Nefropatia per IgA; Nefropatía per IgA; IgA nephropathy; Perfil peptídic; Perfil peptídico; Profile peptides; Alfa-1-antitripsina; Alpha-1-antitrypsin; Ciències de la Salut; 61

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Graterol Torres, F. A. (2019). Aplicación de la proteómica en el estudio de factores pronósticos de la nefropatia IgA. (Thesis). Universitat Autònoma de Barcelona. Retrieved from http://hdl.handle.net/10803/669849

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Graterol Torres, Fredzzia Amada. “Aplicación de la proteómica en el estudio de factores pronósticos de la nefropatia IgA.” 2019. Thesis, Universitat Autònoma de Barcelona. Accessed February 26, 2021. http://hdl.handle.net/10803/669849.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Graterol Torres, Fredzzia Amada. “Aplicación de la proteómica en el estudio de factores pronósticos de la nefropatia IgA.” 2019. Web. 26 Feb 2021.

Vancouver:

Graterol Torres FA. Aplicación de la proteómica en el estudio de factores pronósticos de la nefropatia IgA. [Internet] [Thesis]. Universitat Autònoma de Barcelona; 2019. [cited 2021 Feb 26]. Available from: http://hdl.handle.net/10803/669849.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Graterol Torres FA. Aplicación de la proteómica en el estudio de factores pronósticos de la nefropatia IgA. [Thesis]. Universitat Autònoma de Barcelona; 2019. Available from: http://hdl.handle.net/10803/669849

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

22. BEZERRA, Ana Katarina Moraes Monteiro. DETERMINAÇÃO QUIMILUMINESCENTE DE IgA SECRETORA EM LEITE MATERNO .

Degree: 2012, Universidade Federal de Pernambuco

URL: http://repositorio.ufpe.br/handle/123456789/12603

► O aumento na concentração de IgA Secretora em secreções externas é uma importante ferramenta de diagnóstico para infecções que acometem as mucosas. O uso de… (more)

Subjects/Keywords: IgA secretora; componente secretor; anti-IgA secretora; Dot-ELISA; imunoquimiluminescência; éster de acridina; membrana de nitrocelulose

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

BEZERRA, A. K. M. M. (2012). DETERMINAÇÃO QUIMILUMINESCENTE DE IgA SECRETORA EM LEITE MATERNO . (Thesis). Universidade Federal de Pernambuco. Retrieved from http://repositorio.ufpe.br/handle/123456789/12603

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

BEZERRA, Ana Katarina Moraes Monteiro. “DETERMINAÇÃO QUIMILUMINESCENTE DE IgA SECRETORA EM LEITE MATERNO .” 2012. Thesis, Universidade Federal de Pernambuco. Accessed February 26, 2021. http://repositorio.ufpe.br/handle/123456789/12603.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

BEZERRA, Ana Katarina Moraes Monteiro. “DETERMINAÇÃO QUIMILUMINESCENTE DE IgA SECRETORA EM LEITE MATERNO .” 2012. Web. 26 Feb 2021.

Vancouver:

BEZERRA AKMM. DETERMINAÇÃO QUIMILUMINESCENTE DE IgA SECRETORA EM LEITE MATERNO . [Internet] [Thesis]. Universidade Federal de Pernambuco; 2012. [cited 2021 Feb 26]. Available from: http://repositorio.ufpe.br/handle/123456789/12603.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

BEZERRA AKMM. DETERMINAÇÃO QUIMILUMINESCENTE DE IgA SECRETORA EM LEITE MATERNO . [Thesis]. Universidade Federal de Pernambuco; 2012. Available from: http://repositorio.ufpe.br/handle/123456789/12603

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Oulu

23. Jauhola, O. (Outi). Henoch-Schönlein purpura in children.

Degree: 2012, University of Oulu

URL: http://urn.fi/urn:isbn:9789514297960

►

Abstract The aim of this work was to describe the clinical features and clinical course of Henoch-Schönlein purpura (HSP) in a prospective setting, to compare… (more)

▼

Abstract The aim of this work was to describe the clinical features and clinical course of Henoch-Schönlein purpura (HSP) in a prospective setting, to compare the efficacy of cyclosporine A (CyA) and methylprednisolone (MP) pulses for the treatment of severe HSP nephritis (HSN) and to study the effect of prophylactic prednisone treatment given at disease onset on the long-term outcome. A total of 223 children with newly diagnosed HSP were followed up prospectively for 6 months. Patients with severe HSN also had extrarenal symptoms more frequently during this time. Protein loss via the intestine was more common than previously described, occurring in 3% of the patients. HSN developed in the early course of the disease. The results suggest that weekly urine dipstick tests are indicated for 2 months after HSP onset and individually for over 6 months in cases of HSN or HSP recurrences. Prednisone did not affect the frequency or timing of the appearance of HSN. The efficacy of CyA and MP treatments was evaluated in a trial with a mean follow-up time of 6 years involving 24 paediatric patients (11 CyA, 13 MP), 15 of whom were randomized and 9 were treated according to the given protocol without randomization. Oral CyA was not inferior to intravenous MP pulses and proved to be an efficient, safe steroid-sparing treatment for severe HSN. All the CyA-treated patients achieved remission of nephrotic-range proteinuria within 3 months, while remission was achieved more slowly in the MP group and only in 6/13 (46%) with the initial treatment. There was no difference in the renal biopsy findings two years after initiation of the therapy. The 8-year outcome of HSP was assessed by means of a health questionnaire in 160 (94%) of the 171 former patients in the randomized placebo-controlled prednisone trial and in 138 (81%) with urine analysis and measurement of blood pressure. HSP carried a good prognosis, although skin relapses occurred up to a decade after the initial onset and could be accompanied by late-onset nephritis. Hypertension and/or renal abnormalities were recorded in 13% of the patients, being more frequent in those with an initial occurrence of HSN (OR 4.3, p=0.009, 95% CI 1.4–14.0) and warranting long-term follow-up of HSN patients. Early prednisone treatment did not affect the long-term outcome of HSP and should not be routinely used.

Tiivistelmä Väitöskirjan tarkoituksena oli kuvata Henoch-Schönleinin purppuran (HSP) oireita ja taudinkulkua, verrata siklosporiini A:n (CyA) ja metyyliprednisolonipulssihoidon (MP-pulssihoidon) tehoa vaikean HSP-nefriitin (HSN) hoidossa ja selvittää taudin alussa annetun prednisonihoidon vaikutusta pitkäaikaisennusteeseen. Taudinkulkua seurattiin prospektiivisesti 6 kuukauden ajan diagnoosista 223 lapsipotilaan aineistossa. Potilailla, joilla oli vaikea HSN, esiintyi myös muita oireita pitempään. Proteiinin menetystä suolistoon esiintyi 3 %:lla, mikä on aiemmin kuvattua yleisempää. HSN ilmaantui taudin alkuvaiheessa. Tutkimustulosten perusteella viikoittainen virtsanäytteiden…

Advisors/Committee Members: Nuutinen, M. (Matti).

Subjects/Keywords: IgA glomerulonephritis; Schoenlein-Henoch purpura; corticosteroid treatment; cyclosporine; hematuria; methylprednisolone; prognosis; proteinuria; IgA-nefropatia; ennuste; hematuria; kortisonihoito; metyyliprednisoloni; proteinuria; siklosporiini

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Jauhola, O. (. (2012). Henoch-Schönlein purpura in children. (Doctoral Dissertation). University of Oulu. Retrieved from http://urn.fi/urn:isbn:9789514297960

Chicago Manual of Style (16^th Edition):

Jauhola, O (Outi). “Henoch-Schönlein purpura in children.” 2012. Doctoral Dissertation, University of Oulu. Accessed February 26, 2021. http://urn.fi/urn:isbn:9789514297960.

MLA Handbook (7^th Edition):

Jauhola, O (Outi). “Henoch-Schönlein purpura in children.” 2012. Web. 26 Feb 2021.

Vancouver:

Jauhola O(. Henoch-Schönlein purpura in children. [Internet] [Doctoral dissertation]. University of Oulu; 2012. [cited 2021 Feb 26]. Available from: http://urn.fi/urn:isbn:9789514297960.

Council of Science Editors:

Jauhola O(. Henoch-Schönlein purpura in children. [Doctoral Dissertation]. University of Oulu; 2012. Available from: http://urn.fi/urn:isbn:9789514297960

24. Γερόλυμος, Μιλτιάδης. Θεραπευτική αντιμετώπιση ασθενών με IgA νεφροπάθεια με βάση κλασικούς και νεότερους δείκτες εξέλιξης της νόσου.

Degree: 2014, University of Patras

URL: http://hdl.handle.net/10889/7942

► Η ΙgΑ νεφροπάθεια αποτελεί την πιο συχνή μορφή πρωτοπαθούς σπειραματονεφρίτιδας η οποία αντιμετωπίζεται με την εφαρμογή διαφόρων θεραπευτικών σχημάτων. Στο πρώτο σκέλος της παρούσας διδακτορικής… (more)

▼ Η ΙgΑ νεφροπάθεια αποτελεί την πιο συχνή μορφή πρωτοπαθούς σπειραματονεφρίτιδας η οποία αντιμετωπίζεται με την εφαρμογή διαφόρων θεραπευτικών σχημάτων. Στο πρώτο σκέλος της παρούσας διδακτορικής διατριβής, αξιολογήθηκε η αποτελεσματικότητα θεραπευτικών σχημάτων που χορηγήθηκαν με βάση τα κλινικά και ιστολογικά χαρακτηριστικά των ασθενών με ΙgΑ νεφροπάθεια για περίοδο παρακολούθησης 5 ετών. Στη μελέτη συμπεριελήφθησαν 50 ασθενείς, οι οποίοι χωρίστηκαν σε 4 ομάδες. Ασθενείς με φυσιολογική νεφρική λειτουργία και πρωτεϊνουρία <1,0 g/24h δεν έλαβαν ειδική αγωγή (Ομάδα Α, n=6). Ασθενείς με φυσιολογική νεφρική λειτουργία, πρωτεϊνουρία >1,0 g/24h και με ήπια έως μέτρια μεσαγγειακή υπερπλασία και διαμεσοσωληναριακή συμμετοχή αντιμετωπίστηκαν με αγωγή που περιελάμβανε α-ΜΕΑ και κορτικοστεροειδή (Ομάδα Β, n=23). Ασθενείς με αρχική κρεατινίνη ορού Scr<2,5 mg/dL, πρωτεϊνουρία >3,5 g/24h και/ή μέτριες έως σοβαρές ιστολογικές αλλοιώσεις αντιμετωπίστηκαν με συνδυασμό α-ΜΕΑ, κορτικοστεροειδών και άλλων ανοσοκατασταλτικών φαρμάκων (Ομάδα Γ, n=18). Ασθενείς με αρχική τιμή Scr >2,5 mg/dL, με παρουσία σοβαρής σπειραματοσκλήρυνσης και διαμεσοσωληναριακής βλάβης αντιμετωπίστηκαν μόνο με α-ΜΕΑ και ιχθυέλαια (Ομάδα Δ, n=3). Από τους 50 ασθενείς, οι 9 (18%) παρουσίασαν διπλασιασμό της αρχικής κρεατινίνης ορού, 2 από την ομάδα Β (8,7%), 5 από την ομάδα Γ (27,7%) και 2 από την ομάδα Δ (66,7%). Από τους 7 ασθενείς που εμφάνισαν νεφρική ανεπάρκεια τελικού σταδίου, ένας ήταν από την ομάδα Β (4,3%), 4 από την ομάδα Γ (22%) και 2 από την ομάδα Δ (66,7%). Ύφεση της πρωτεϊνουρίας παρατηρήθηκε σε όλους τους ασθενείς της ομάδας Β και σε 15 ασθενείς της ομάδας Γ (83,3%). Παρενέργειες παρατηρήθηκαν σε 3 (7,3%) ασθενείς που έλαβαν ανοσοκατασταλτική αγωγή. Σε ασθενείς με IgA νεφροπάθεια η χορήγηση εξατομικευμένου θεραπευτικού σχήματος που βασίζεται στα κλινικά και ιστολογικά χαρακτηριστικά ενός εκάστου των ασθενών φαίνεται ότι μπορεί να οδηγήσει στην επίτευξη του μέγιστου θεραπευτικού αποτελέσματος με τον ελάχιστο κίνδυνο ανεπιθύμητων ενεργειών. Στο δεύτερο σκέλος μελετήθηκαν δυνητικά πρώιμοι δείκτες εξέλιξης της νεφρικής βλάβης τόσο στον νεφρικό ιστό, όσο και σε ούρα ασθενών. Μελέτες στο γονιδίωμα και το πρωτέωμα υποδηλώνουν ότι η τρανσγελίνη πιθανόν εμπλέκεται στην νεφρική βλάβη μέσω ενεργοποίησης των μυοϊνοβλαστών. Σε τομές νεφρικού ιστού 67 ασθενών έγινε ανίχνευση με ανοσοϊστοχημική μέθοδο και ανοσοφθορισμό και ποσοτική εκτίμηση της παρουσίας αφενός μεν της τρανσγελίνης αφετέρου της α-ακτίνης των λείων μυϊκών ινών (α-SMA), γνωστού δείκτη ενεργοποίησης των μυοϊνοβλαστών στο νεφρικό ιστό. Έκφραση της τρανσγελίνης και της α-SMA εντοπίστηκαν στα σπειράματα και στο διάμεσο χώρο. Σε ασθενείς με IgA νεφροπάθεια και εστιακή τμηματική σπειραματοσκλήρυνση η έκφραση της τρανσγελίνης ήταν εντονότερη από αυτήν της α-SMA. Η ανοσοϊστοχημική έκφραση της τρανσγελίνης σχετιζόταν με το βαθμό σπειραματικής σκλήρυνσης (p=0,035) και ίνωσης του διάμεσου χώρου (p=0,047), με το βαθμό μεσαγγειακής υπερπλασίας (p=0,034), με την ύφεση της λευκωματουρίας (p=0,041) και την έκβαση… Advisors/Committee Members: Γούμενος, Δημήτριος, Gerolymos, Miltiadis, Παπαγιάννη, Αικατερίνη, Τσαμαντάς, Αθανάσιος, Αντωνόπουλος, Ανδρέας, Γώγος, Χαράλαμπος, Καλόφωνος, Χαράλαμπος, Μαραγκός, Μάρκος.

Subjects/Keywords: IgA νεφροπάθεια; Τρανσγελίνη; Κυτταροκίνες; Προγνωστικοί δείκτες; 616.612 06; IgA nephropathy; Transgelin; Cytokines; Potential early markers for progression

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Γερόλυμος, �. (2014). Θεραπευτική αντιμετώπιση ασθενών με IgA νεφροπάθεια με βάση κλασικούς και νεότερους δείκτες εξέλιξης της νόσου. (Doctoral Dissertation). University of Patras. Retrieved from http://hdl.handle.net/10889/7942

Chicago Manual of Style (16^th Edition):

Γερόλυμος, Μιλτιάδης. “Θεραπευτική αντιμετώπιση ασθενών με IgA νεφροπάθεια με βάση κλασικούς και νεότερους δείκτες εξέλιξης της νόσου.” 2014. Doctoral Dissertation, University of Patras. Accessed February 26, 2021. http://hdl.handle.net/10889/7942.

MLA Handbook (7^th Edition):

Γερόλυμος, Μιλτιάδης. “Θεραπευτική αντιμετώπιση ασθενών με IgA νεφροπάθεια με βάση κλασικούς και νεότερους δείκτες εξέλιξης της νόσου.” 2014. Web. 26 Feb 2021.

Vancouver:

Γερόλυμος �. Θεραπευτική αντιμετώπιση ασθενών με IgA νεφροπάθεια με βάση κλασικούς και νεότερους δείκτες εξέλιξης της νόσου. [Internet] [Doctoral dissertation]. University of Patras; 2014. [cited 2021 Feb 26]. Available from: http://hdl.handle.net/10889/7942.

Council of Science Editors:

Γερόλυμος �. Θεραπευτική αντιμετώπιση ασθενών με IgA νεφροπάθεια με βάση κλασικούς και νεότερους δείκτες εξέλιξης της νόσου. [Doctoral Dissertation]. University of Patras; 2014. Available from: http://hdl.handle.net/10889/7942

25. Wehbe, Batoul. IgA et rein : destructrice ou protectrice ? : Rôles de l'immunoglobuline A (IgA) dans deux pathologies rénales : IgA and kidney : Role of immunoglobulin A (IgA) on two renal pathologies.

Degree: Docteur es, Immunologie, oncologie et infectiologie, 2018, Limoges; Université libanaise

URL: http://www.theses.fr/2018LIMO0034

►

L’immunoglobuline A (IgA) est l’immunoglobuline la plus abondamment synthétisée chez les mammifères. Ses propriétés ambivalentes l’impliquent non seulement dans des fonctions de protection contre les… (more)

▼

L’immunoglobuline A (IgA) est l’immunoglobuline la plus abondamment synthétisée chez les mammifères. Ses propriétés ambivalentes l’impliquent non seulement dans des fonctions de protection contre les agents pathogènes mais aussi dans des phénomènes de tolérance immunitaire vis-à-vis des germes commensaux du microbiote. Toutefois, les IgA peuvent développer des propriétés pathogènes. Dans la première partie de mon travail de thèse, nous avons étudié les effets pathogènes de l’IgA. Les dépôts d’IgA sur le mésangium sont la caractéristique de l’IgAN. La physiopathologie de cette maladie est mal connue. L’hypothèse d’un défaut de glycosylation de l’IgA est souvent retenue ; ce défaut peut être la cause de sa polymérisation et de son antigénicité, il peut aussi favoriser le clivage du récepteur CD89. Nous avons analysé l’effet du défaut d’affinité de la région variable des IgA, de la substitution de la chaîne légère ainsi que de l’association des IgA à leur récepteur, le CD89 sur l’induction des lésions et le dysfonctionnement rénal chez quatre modèles murins différents générés au laboratoire et suivis pendant 12 mois. Nous avons également étudié les propriétés physico-chimiques des IgA de 28 patients ayant une dysglobulinémie et de 28 IgA produites par des hybridomes ; la relation entre ces propriétés et la capacité des IgA à se déposer a été observée. Dans une seconde partie, nous avons étudié l’aspect immunomodulateur et les propriétés antiinflammatoires conférées par l’IgA humaine surexprimée chez un modèle murin de lupus systémique (souris MRL/lpr). Dans la dernière partie du travail, nous avons contribué à la caractérisation d’un modèle de souris transgénique exprimant l’IgA de classe 2 et à l’étude de l’effet de signalisation médiée par cette IgA2 sur le développement des populations lymphocytaires. L’ensemble de ces travaux a montré l’effet pathogène des IgA naturelles ayant une faible affinité sur le développement de la néphropathie à IgA ; ainsi les analyses des IgA des patients et des hybridomes montrent que c’est la stabilité moléculaire de préférence au profil de glycosylation qui joue un rôle crucial dans leur capacité de dépôt. L’expression des IgA humaines chez les souris lupiques a considérablement prolongé leur durée de vie et a ralenti la survenue de l’auto-immunité et de l’atteinte rénale ce qui témoigne du rôle anti-inflammatoire des IgA. L’étude du modèle murin exprimant l’IgA2 humaine a montré que la signalisation via l’IgA2 joue un rôle inhibiteur sur le développement précoce de certaines sous-populations de cellules B. L’ensemble de ces résultats montrent la multitude d’effets de l’IgA lui permettant d’intervenir d’une part dans la pathogenèse d’une maladie complexe (l’IgAN) et d’autre part dans la protection de l’auto-immunité, témoignant de la complexité des interactions mises en jeu et du caractère régulateur de cette immunoglobuline.

Immunoglobulin A (IgA) is the most synthetized immunoglobulin in mammals. IgA has ambivalent properties: it is implicated in the mechanisms of defense against…

Advisors/Committee Members: Aldigier, Jean-Claude (thesis director), Badran, Bassam (thesis director), Cogné, Michel (thesis director), El Makhour, Yolla (thesis director).

Subjects/Keywords: Immunoglobuline A; Modèle murin; Néphropathie à IgA; Immunomodulation; IgA2; Immunoglobulin A; Mouse model; IgA nephropathy; Immunomodulation; IgA2; 615.37

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Wehbe, B. (2018). IgA et rein : destructrice ou protectrice ? : Rôles de l'immunoglobuline A (IgA) dans deux pathologies rénales : IgA and kidney : Role of immunoglobulin A (IgA) on two renal pathologies. (Doctoral Dissertation). Limoges; Université libanaise. Retrieved from http://www.theses.fr/2018LIMO0034

Chicago Manual of Style (16^th Edition):

Wehbe, Batoul. “IgA et rein : destructrice ou protectrice ? : Rôles de l'immunoglobuline A (IgA) dans deux pathologies rénales : IgA and kidney : Role of immunoglobulin A (IgA) on two renal pathologies.” 2018. Doctoral Dissertation, Limoges; Université libanaise. Accessed February 26, 2021. http://www.theses.fr/2018LIMO0034.

MLA Handbook (7^th Edition):

Wehbe, Batoul. “IgA et rein : destructrice ou protectrice ? : Rôles de l'immunoglobuline A (IgA) dans deux pathologies rénales : IgA and kidney : Role of immunoglobulin A (IgA) on two renal pathologies.” 2018. Web. 26 Feb 2021.

Vancouver:

Wehbe B. IgA et rein : destructrice ou protectrice ? : Rôles de l'immunoglobuline A (IgA) dans deux pathologies rénales : IgA and kidney : Role of immunoglobulin A (IgA) on two renal pathologies. [Internet] [Doctoral dissertation]. Limoges; Université libanaise; 2018. [cited 2021 Feb 26]. Available from: http://www.theses.fr/2018LIMO0034.

Council of Science Editors:

Wehbe B. IgA et rein : destructrice ou protectrice ? : Rôles de l'immunoglobuline A (IgA) dans deux pathologies rénales : IgA and kidney : Role of immunoglobulin A (IgA) on two renal pathologies. [Doctoral Dissertation]. Limoges; Université libanaise; 2018. Available from: http://www.theses.fr/2018LIMO0034

26. Gribonika, Inta. Regulation of gut IgA induction by helper T cells.

Degree: 2019, University of Gothenburg / Göteborgs Universitet

URL: http://hdl.handle.net/2077/61681

► The gut is the largest lymphoid organ in the body. Due to intense and constant exposure to the outside world, it also functions as the… (more)

▼ The gut is the largest lymphoid organ in the body. Due to intense and constant exposure to the outside world, it also functions as the most important portal of entry for many pathogens. T cell-dependent secretory immunoglobulin A (IgA) prevents pathogens from spreading to systemic tissues and, hence, oral immunization represents the most effective route for vaccination against these pathogens. The detailed mechanism of oral vaccination-induced protective IgA immunity is not fully understood. The main aim of this thesis was to investigate the role of the gut CD4 T subsets for the induction of IgA responses. By using Ovalbumin-specific TCR-Tg CD4 T cells in an adoptive transfer system and mucosal immunization with or without cholera toxin (CT) adjuvant I show that IgA induction in the Peyer's patch (PP) is regulated in a distinct two-step process, where T follicular helper cells (TFH) and thymus-derived T regulatory cells (tTreg) orchestrate the IgA induction. Effective B cell help in the germinal center (GC) is maintained by antigen-specific TFH cells, while IgA class-switch recombination (CSR) is promoted by tTregs independently of the immunizing antigen. It should be emphasized that the default response pathway activated by oral antigen administration is oral tolerance. In this doctoral thesis, I demonstrate that the suppressive pathway is regulated by IL-10. Thus, CD4 T cells upon exposer to cognate antigen in the presence of IL-10 differentiate into peripherally induced Tregs (pTreg). In the absence of IL-10 or after addition of CT adjuvant TFH differentiation is enhanced, resulting in a strong gut IgA response. CT has been reported to be the most potent oral adjuvant. Some reports suggest that CT preferentially exerts the adjuvant function via Th17 cells. The immuno-dominant part of CT is its B subunit, therefore, I used CTB-specific tetramer to monitor if CT induced T cell response is dominated by Th17 cells. Surprisingly, the CTB-specific T cell repertoire was nearly absent of Th17 lineage, however that did not prevent adjuvant’s ability to induce a strong gut IgA response. Instead, CT induced CD4 T cells were overrepresented by TFH lineage that did not derive from Th17 cells as shown by using IL-17 fate reporter mice. These observations were confirmed using single-cell RNAseq technology. Gene signature of sorted CTB-specific CD4 T cells showed an almost complete dominance of the TFH phenotype with virtually no Th17 signature. Besides, the adoptive transfer of Th17 deficient CD4 T cells (Rorc-/-) into nude host allowed for a robust gut IgA induction after oral immunization with CT. These findings argue strongly against the observations that upon CT immunization gut IgA B cell responses are driven by Th17 cells that exhibit great plasticity towards the TFH lineage. Interestingly, obtained data suggest that TFH cells in the PP do not share clonal relatedness with Th17, Th1 or Treg cells which have been a long-standing controversy in this field. Together, these findings provide a new paradigm for how gut IgA…

Subjects/Keywords: mucosal immunology; secretory IgA; T regulatory cells; T follicular helper cells; Th17 cells; Peyer's patches; IgA class-switch recombination; germinal centers

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Gribonika, I. (2019). Regulation of gut IgA induction by helper T cells. (Thesis). University of Gothenburg / Göteborgs Universitet. Retrieved from http://hdl.handle.net/2077/61681

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Gribonika, Inta. “Regulation of gut IgA induction by helper T cells.” 2019. Thesis, University of Gothenburg / Göteborgs Universitet. Accessed February 26, 2021. http://hdl.handle.net/2077/61681.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Gribonika, Inta. “Regulation of gut IgA induction by helper T cells.” 2019. Web. 26 Feb 2021.

Vancouver:

Gribonika I. Regulation of gut IgA induction by helper T cells. [Internet] [Thesis]. University of Gothenburg / Göteborgs Universitet; 2019. [cited 2021 Feb 26]. Available from: http://hdl.handle.net/2077/61681.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Gribonika I. Regulation of gut IgA induction by helper T cells. [Thesis]. University of Gothenburg / Göteborgs Universitet; 2019. Available from: http://hdl.handle.net/2077/61681

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

27. Hennino, Marie-Flore. Rôle de miR-21 au cours de la réponse à une agression rénale : Role of miR-21-5p in the response after a renal damage.

Degree: Docteur es, Biologie des organismes, 2017, Université Lille II – Droit et Santé

URL: http://www.theses.fr/2017LIL2S010

► Toute maladie rénale chronique (MRC) se caractérise par le développement de lésions de fibrose rénale et d’une perte de fonction qui peut, à terme conduire… (more)

▼ Toute maladie rénale chronique (MRC) se caractérise par le développement de lésions de fibrose rénale et d’une perte de fonction qui peut, à terme conduire vers l’insuffisance rénale chronique terminale. miR-21-5p est un microARN ubiquitaire impliqué dans le processus de fibrose, notamment rénale. Toutefois, des données expérimentales contradictoires suggèrent que miR-21-5p joue un rôle ambivalent dans la constitution des lésions rénales de fibrose.L’objectif de ce travail est de préciser l’implication de miR-21 au cours des lésions rénales aigües, en s’appuyant sur un modèle murin de toxicité rénale du cisplatine, ou chroniques chez l’homme au cours de la néphropahtie à dépôts mésangiaux d’IgA (maladie de Berger).Dans un premier travail, une cohorte rétrospective de patients porteurs d’une néphropathie à dépôts mésangiaux d’IgA a été caractérisée de façon systématique sur le plan clinico-biologique et anatomo-pathologique (classification d’Oxford). L’expression rénale de trois fibromiR (miR-21-5p, miR-199a-5p et miR-214-3p) est associée aux lésions de fibrose rénale (p ≤ 0,02). Parmi ces microARN, miR-21-5p semble le plus pertinent car il présente des amplitudes de variation d’expression plus importantes selon le niveau de fibrose, il est également associé aux lésions de sclérose glomérulaire (p = 0,001) et son niveau d’expression tissulaire rénale est associée à une moins bonne survie rénale.Un second travail a été mené en utilisant un modèle murin d’insuffisance rénale aiguë secondaire à l’injection intra-péritonéale de cisplatine chez des animaux invalidé pour miR-21a-5p. Deux schémas d’injections ont été réalisés afin explorer le rôle de miR-21a-5p au cours de lésions rénales aiguës (injection d’une dose unique de 10mg/kg de cisplatine) ou subaiguës (injections répétées de 7 mg/kg de cisplatine). Les souris ayant reçu une injection unique de cisplatine ne présentent pas de différence significative d’urée sanguine, de marqueurs de souffrance rénale (NGAL, KIM-1), d’inflammation (TNF-α, IL-6) et de stress oxydant (HO-1, NRF2), ni d’activité apoptotique selon leur statut sauvage ou invalidé pour miR-21a-5p. Le modèle d’injections répétées de cisplatine a, quant à lui, permis de mettre en évidence des lésions plus importantes chez les souris miR-21-/-. En effet, les souris miR-21-/- cisplatine présentent une urée sanguine plus élevée (1,92 g/l ±, 0,72 versus 0,66 g/l ± 0,15 p = 0,014) et une expression rénale de NGAL plus importante (RQ = 118,1 ± 44,8 versus RQ = 45,4 ± 37,7, p= 0,018) que le souris sauvages cisplatine. Enfin les lésions rénales de nécrose tubulaire aiguë observées sont plus sévères chez les souris miR-21-/-.Ainsi ces résultats montrent qu’une forte expression rénale de miR-21-5p est associée à la fibrose et au pronostic rénal chez des patients porteurs d’une néphropathie à dépôts mésangiaux d’IgA. Dans notre modèle expérimental, les souris déficientes pour miR-21a-5p présentent une sensibilité variable au développement de lésions rénales induites par le cisplatine en fonction du type… Advisors/Committee Members: Cauffiez, Christelle (thesis director), Glowacki, François (thesis director).

Subjects/Keywords: MiR-21; Rein; Fibrose; Néphropathie à IgA; Nécrose tubulaire aiguë; Cisplatine; MiR-21; Kidney; Fibrosis; IgA nephropathy; Acute kidney injury; Cisplatin

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Hennino, M. (2017). Rôle de miR-21 au cours de la réponse à une agression rénale : Role of miR-21-5p in the response after a renal damage. (Doctoral Dissertation). Université Lille II – Droit et Santé. Retrieved from http://www.theses.fr/2017LIL2S010

Chicago Manual of Style (16^th Edition):

Hennino, Marie-Flore. “Rôle de miR-21 au cours de la réponse à une agression rénale : Role of miR-21-5p in the response after a renal damage.” 2017. Doctoral Dissertation, Université Lille II – Droit et Santé. Accessed February 26, 2021. http://www.theses.fr/2017LIL2S010.

MLA Handbook (7^th Edition):

Hennino, Marie-Flore. “Rôle de miR-21 au cours de la réponse à une agression rénale : Role of miR-21-5p in the response after a renal damage.” 2017. Web. 26 Feb 2021.

Vancouver:

Hennino M. Rôle de miR-21 au cours de la réponse à une agression rénale : Role of miR-21-5p in the response after a renal damage. [Internet] [Doctoral dissertation]. Université Lille II – Droit et Santé 2017. [cited 2021 Feb 26]. Available from: http://www.theses.fr/2017LIL2S010.

Council of Science Editors:

Hennino M. Rôle de miR-21 au cours de la réponse à une agression rénale : Role of miR-21-5p in the response after a renal damage. [Doctoral Dissertation]. Université Lille II – Droit et Santé 2017. Available from: http://www.theses.fr/2017LIL2S010

28. Rao, Subba Chintalacharuvu. Interleukins 4 and 5 alter IgA glycosylation: Ramifications for the pathogenesis of IgA nephropathy.

Degree: PhD, Pathology, 1996, Case Western Reserve University School of Graduate Studies

URL: http://rave.ohiolink.edu/etdc/view?acc_num=case1062077056

► This research offers insights to the pathogenesis of IgA nephropathy, the most common form of glomerulonephritis and a major contributor to end-stage renal disease. Lymphocytes… (more)

▼ This research offers insights to the pathogenesis of IgA nephropathy, the most common form of glomerulonephritis and a major contributor to end-stage renal disease. Lymphocytes from IgA nephropathy patients hyperproduce IgA1 and hyperproduce cytokines, specifically IL-4 and IL-5, derived from the Th2 subset of helper T cells. We hypothesize that Th2 cytokines not only increase the production of IgA from B cells, but are also responsible for an alteration in glycosylation of IgA which in turn favors formation, circulation and/or glomerular deposition of IgA immune complexes. In order to test our hypothesis, we sought to examine the effects of IL-4 plus IL-5 upon IgA synthesis and its glycosylation by B cells at various differentiation stages. A novel lectin assay was developed to detect the terminal glycosylation of IgA. For in vitro studies, we used CH12LX cells, which exist clonally as "pre-switch" (membrane IgM+) B cells, and adapted a subclone of the same cell line as "post-switch" (membrane IgA+) B cells. For plasma cells, we selected both TEPC-15 and MOPC-315 plasmacytomas. Our results suggest that IL-4 plus IL-5 have a more profound effect in decreasing terminal sialic acid and terminal ga lactose on IgA produced from "pre-switch" B cells than on "post-switch" B cells, and no effect on plasma cells. Independent chemically based approaches, like monosaccharide analysis and N-linked profiling, confirmed lectin data. To show biological relevance of our in vitro experiments, we generated antigen-specific IgA, by exoglycosidase treatment, that resembled the IgA derived after IL-4 plus IL-5 stimulation of B cells. Immune complexes prepared with this IgA, when injected into mice, deposited more rapidly in kidneys and activated complement better than those with normally glycosylated IgA. In conclusion, our studies for the first time demonstrated that IL-4 plus IL-5 have an effect on the glycosylation of IgA and that this IgA is more easily deposited in the glomeruli. Reconstituting the normal glycosylation of IgA by gene therapy might be an effective therapeutic strategy for IgA nephropathy in the future Advisors/Committee Members: Emancipator, Steven (Advisor).

Subjects/Keywords: Health Sciences, Pathology; IgA glycoslation; IgA nephropathy; Interlukins-4,5

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Rao, S. C. (1996). Interleukins 4 and 5 alter IgA glycosylation: Ramifications for the pathogenesis of IgA nephropathy. (Doctoral Dissertation). Case Western Reserve University School of Graduate Studies. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=case1062077056

Chicago Manual of Style (16^th Edition):

Rao, Subba Chintalacharuvu. “Interleukins 4 and 5 alter IgA glycosylation: Ramifications for the pathogenesis of IgA nephropathy.” 1996. Doctoral Dissertation, Case Western Reserve University School of Graduate Studies. Accessed February 26, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=case1062077056.

MLA Handbook (7^th Edition):

Rao, Subba Chintalacharuvu. “Interleukins 4 and 5 alter IgA glycosylation: Ramifications for the pathogenesis of IgA nephropathy.” 1996. Web. 26 Feb 2021.

Vancouver:

Rao SC. Interleukins 4 and 5 alter IgA glycosylation: Ramifications for the pathogenesis of IgA nephropathy. [Internet] [Doctoral dissertation]. Case Western Reserve University School of Graduate Studies; 1996. [cited 2021 Feb 26]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1062077056.

Council of Science Editors:

Rao SC. Interleukins 4 and 5 alter IgA glycosylation: Ramifications for the pathogenesis of IgA nephropathy. [Doctoral Dissertation]. Case Western Reserve University School of Graduate Studies; 1996. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1062077056

29. Iida, Tomoko. Decreased urinary calbindin 1 levels in proteinuric rats and humans with distal nephron segment injuries : 遠位尿細管傷害のラットとヒトにおける尿中calbindin1蛋白質排泄の減少について.

Degree: 博士（医学）, 2015, Niigata University / 新潟大学

URL: http://hdl.handle.net/10191/32270

►

学位の種類: 博士（医学）. 報告番号: 甲第3986号. 学位記番号: 新大院博（医）甲第632号. 学位授与年月日: 平成27年3月23日

Clinical and Experimental Nephrology. 2014, 18(3), 432-443.

"Background: Several proteins have been proposed as new urinary biomarkers… (more)

▼

学位の種類: 博士（医学）. 報告番号: 甲第3986号. 学位記番号: 新大院博（医）甲第632号. 学位授与年月日: 平成27年3月23日

Clinical and Experimental Nephrology. 2014, 18(3), 432-443.

"Background: Several proteins have been proposed as new urinary biomarkers of kidney injuries, but they are not always capable of identifying the kidney nephron segment that has been injured. Since calbindin 1 protein is exclusively localized in the kidney distal nephron segment, it is presumed that its expression is altered during distal nephron segment injuries, resulting in changes in its urinary excretion. Methods Calbindin 1 expression in normal rat kidneys was compared with that in the kidneys of rats that had suffered distal nephron segment injuries (unilateral ureteral obstruction [UUO] or anti-glomerular basement membrane glomerulonephritis [anti-GBM GN]) using immunohistochemical examinations and real-time polymerase chain reaction. The urinary calbindin 1 protein concentration of normal rats was also compared with that of anti-GBM GN rats and of cisplatin nephropathy rats using Western blotting. We also compared the kidney and urinary calbindin 1 protein concentrations of normal human subjects with those of proteinuric patients [immunoglobulin (Ig)A nephropathy; IgAN] with distal nephron segment injuries. Results: Calbindin 1 mRNA expression in the renal cortices and calbindin 1 protein expression in the kidney distal nephron segments were decreased in the UUO and anti-GBM GN rat kidneys. The urinary calbindin 1 protein levels of the anti-GBM GN rats were also markedly decreased, whereas those of the cisplatin nephropathy rats were slightly decreased. The human IgAN patients displayed decreased renal calbindin 1 protein expression intheir dilated distal tubules, and some patients displayed decreased urinary calbindin 1 levels. Conclusion: Since it has been demonstrated that decreased urinary calbindin 1 levels are indicative of decreased calbindin 1 kidney expression due to distal nephron segment injuries, calbindin 1 might be a useful urinary biomarker for identifying distal nephron segment injuries."

Subjects/Keywords: Immunohistochemistry; Real-time PCR; Western blotting; Anti-GBM glomerulonephritis; IgA nephropathy

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Iida, T. (2015). Decreased urinary calbindin 1 levels in proteinuric rats and humans with distal nephron segment injuries : 遠位尿細管傷害のラットとヒトにおける尿中calbindin1蛋白質排泄の減少について. (Thesis). Niigata University / 新潟大学. Retrieved from http://hdl.handle.net/10191/32270

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Iida, Tomoko. “Decreased urinary calbindin 1 levels in proteinuric rats and humans with distal nephron segment injuries : 遠位尿細管傷害のラットとヒトにおける尿中calbindin1蛋白質排泄の減少について.” 2015. Thesis, Niigata University / 新潟大学. Accessed February 26, 2021. http://hdl.handle.net/10191/32270.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Iida, Tomoko. “Decreased urinary calbindin 1 levels in proteinuric rats and humans with distal nephron segment injuries : 遠位尿細管傷害のラットとヒトにおける尿中calbindin1蛋白質排泄の減少について.” 2015. Web. 26 Feb 2021.

Vancouver:

Iida T. Decreased urinary calbindin 1 levels in proteinuric rats and humans with distal nephron segment injuries : 遠位尿細管傷害のラットとヒトにおける尿中calbindin1蛋白質排泄の減少について. [Internet] [Thesis]. Niigata University / 新潟大学; 2015. [cited 2021 Feb 26]. Available from: http://hdl.handle.net/10191/32270.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Iida T. Decreased urinary calbindin 1 levels in proteinuric rats and humans with distal nephron segment injuries : 遠位尿細管傷害のラットとヒトにおける尿中calbindin1蛋白質排泄の減少について. [Thesis]. Niigata University / 新潟大学; 2015. Available from: http://hdl.handle.net/10191/32270

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

30. Morais, Viviane Martha Santos de. Dosagem da IgA sérica por ELISA de captura para o diagnóstico de dengue .

Degree: 2013, Universidade Federal de Pernambuco

URL: http://repositorio.ufpe.br/handle/123456789/11673

► Introdução: O diagnóstico rápido, simples e preciso para confirmar a infecção pelo vírus dengue (DENV) é uma necessidade real, uma vez que a doença pode… (more)

▼ Introdução: O diagnóstico rápido, simples e preciso para confirmar a infecção pelo vírus dengue (DENV) é uma necessidade real, uma vez que a doença pode se manifestar com um amplo espectro de sinais e sintomas, similares a outros quadros febris agudos. Durante a infecção por dengue se verifica também a produção da imunoglobulina A (IgA) específica, que aumenta ao mesmo tempo que a imunoglobulina M (IgM), permanece positiva por um período de tempo mais curto e se apresenta em níveis mais elevados na infecção secundária. Objetivo: O presente estudo teve como objetivo investigar a presença de IgA no soro durante a infecção primária e secundária (sequencial) pelo DENV. Metodologia: Foram avaliadas amostras de soro por meio do teste imunoenzimático de captura da IgA (AAC-ELISA) in house. Resultados: Avaliou-se um total de 445 amostras de soro, sendo 171 caracterizados como infecção primária e 194 secundária; 40 amostras de indivíduos saudáveis negativos para dengue e 40 de vacinados contra febre amarela. As amostras foram distribuídas em 13 grupos. A positividade da IgA foi de 42,2% (154/365), sendo 27,5% (47/171) na infecção primária e 55,2% (107/194) na secundária. Na infecção secundária, a IgA foi detectada do 2º ao 4º dias de sintomas (grupo 1), antes mesmo da IgM, assim como no grupo 11 no qual a IgM não havia sido detectada (infecção secundária). Na infecção primária o maior valor da sensibilidade foi de 60,0 (36,4 - 80,0) no grupo com 30-35 dias de sintomas e na secundária foi de 87,5% (60,4 – 97,8), grupo com 8 dias de sintomas. A especificidade foi de 100% nas duas infecções (94,3 – 100). Ao aplicar o teste em paralelo para ambas técnicas observou-se um aumento global de 6,6% na sensibilidade do diagnóstico; sendo 2,7% para a infecção primária e de 15,2% para a secundária. A IgA não foi detectada nas amostras dos indivíduos saudáveis, nem nas amostras dos indivíduos recentemente vacinados contra febre amarela. Conclusões: A detecção da IgA demonstrou ser útil como forma de diagnóstico sorológico e em conjunto com a detecção da IgM poderá auxiliar na confirmação de casos agudos de dengue e na interpretação dos resultados de casos inconclusivos, permitindo a adoção de medidas preventivas para evitar a ocorrência de epidemias e ocorrência de casos graves e óbitos. Advisors/Committee Members: Cordeiro, Marli Tenório (advisor), Coêlho, Maria Rosângela Cunha Duarte (advisor).

Subjects/Keywords: Dengue; IgA; IgM; ELISA; Infecção primária; Infecção secundária.

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Morais, V. M. S. d. (2013). Dosagem da IgA sérica por ELISA de captura para o diagnóstico de dengue . (Thesis). Universidade Federal de Pernambuco. Retrieved from http://repositorio.ufpe.br/handle/123456789/11673

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Morais, Viviane Martha Santos de. “Dosagem da IgA sérica por ELISA de captura para o diagnóstico de dengue .” 2013. Thesis, Universidade Federal de Pernambuco. Accessed February 26, 2021. http://repositorio.ufpe.br/handle/123456789/11673.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Morais, Viviane Martha Santos de. “Dosagem da IgA sérica por ELISA de captura para o diagnóstico de dengue .” 2013. Web. 26 Feb 2021.

Vancouver:

Morais VMSd. Dosagem da IgA sérica por ELISA de captura para o diagnóstico de dengue . [Internet] [Thesis]. Universidade Federal de Pernambuco; 2013. [cited 2021 Feb 26]. Available from: http://repositorio.ufpe.br/handle/123456789/11673.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Morais VMSd. Dosagem da IgA sérica por ELISA de captura para o diagnóstico de dengue . [Thesis]. Universidade Federal de Pernambuco; 2013. Available from: http://repositorio.ufpe.br/handle/123456789/11673

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Open Access Theses and Dissertations