subject:(Idiopathic rapidly progressive glomerulonephritis)

Aristotle University Of Thessaloniki (AUTH); Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης (ΑΠΘ)

1. Γιονανλής, Λάζαρος. Συμβολή στην παθογένεια της ιδιοπαθούς ταχέως εξελισσόμενης σπειραματονεφρίτιδας.

Degree: 2003, Aristotle University Of Thessaloniki (AUTH); Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης (ΑΠΘ)

URL: http://hdl.handle.net/10442/hedi/13982

Subjects/Keywords: Ιδιοπαθής ταχέως εξελισσόμενη σπειραματονεφρίτιδα; Αντισώματα κατά κυτταροπλάσματος ουδετεροφίλων; Παθογενετικοί μηχανισμοί; Θεραπείας απάντηση; Ιντεγκρίνες; Διακυτταρικό μόριο προσκόλλησης ICAM-1; Αυξητικός παράγοντας μεταμόρφωσης TGF-B1; Τελικό σύμπλεγμα συμπληρώματος C5b-9; Idiopathic rapidly progressive glomerulonephritis; Antineutrophil cytoplasmic antibodies; Pathogenetic mechanisms; Response to treatment; Intercellular adhesion molecule ICAM -1; Transforming growth factor TGF-b1; Terminal complement component C5b-9

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Γιονανλής, . �. (2003). Συμβολή στην παθογένεια της ιδιοπαθούς ταχέως εξελισσόμενης σπειραματονεφρίτιδας. (Thesis). Aristotle University Of Thessaloniki (AUTH); Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης (ΑΠΘ). Retrieved from http://hdl.handle.net/10442/hedi/13982

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Γιονανλής, Λάζαρος. “Συμβολή στην παθογένεια της ιδιοπαθούς ταχέως εξελισσόμενης σπειραματονεφρίτιδας.” 2003. Thesis, Aristotle University Of Thessaloniki (AUTH); Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης (ΑΠΘ). Accessed April 10, 2021. http://hdl.handle.net/10442/hedi/13982.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Γιονανλής, Λάζαρος. “Συμβολή στην παθογένεια της ιδιοπαθούς ταχέως εξελισσόμενης σπειραματονεφρίτιδας.” 2003. Web. 10 Apr 2021.

Vancouver:

Γιονανλής �. Συμβολή στην παθογένεια της ιδιοπαθούς ταχέως εξελισσόμενης σπειραματονεφρίτιδας. [Internet] [Thesis]. Aristotle University Of Thessaloniki (AUTH); Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης (ΑΠΘ); 2003. [cited 2021 Apr 10]. Available from: http://hdl.handle.net/10442/hedi/13982.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Γιονανλής �. Συμβολή στην παθογένεια της ιδιοπαθούς ταχέως εξελισσόμενης σπειραματονεφρίτιδας. [Thesis]. Aristotle University Of Thessaloniki (AUTH); Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης (ΑΠΘ); 2003. Available from: http://hdl.handle.net/10442/hedi/13982

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

2. Stratakis, Stavros. Μελέτη της έκφρασης ποδοκυτταρικών πρωτεϊνών στη μεμβρανώδη σπειραματονεφρίτιδα.

Degree: 2015, University of Crete (UOC); Πανεπιστήμιο Κρήτης

URL: http://hdl.handle.net/10442/hedi/36610

► Up until the end of 1990’s idiopathic membranous nethropathy (IMN) was the most frequent nephropathy among male adults. Gradually, due to the extension of diagnostic… (more)

▼ Up until the end of 1990’s idiopathic membranous nethropathy (IMN) was the most frequent nephropathy among male adults. Gradually, due to the extension of diagnostic renal biopsies to the poorer spanish-spoken and black population, the frequency of IMN was reduced from 30% to 15-23% but remained the most common glomerulopathy among adult male Caucasians. IMN is characterized by thickening of the glomerular basement membrane (GBM), subepithelial deposition of immune complexes, eradication of the foot processes and progressive extension of basement membrane all-around the depositions (spikes), in order to isolate and absorb them. Alongside, IgG and C3 deposits are detected by immunofluorescence whereas the cellularity of the glomerular tuft is not substantially increased.Pathogenetically, IMN is caused by the deposition of autoantibodies in the sybepithelial aspect of the GBM and the subsequent activation of complement. Recent studies have shown that the antigenic target of the circulating antibodies in the majority of cases of IMN (70%) is phospholipase A2 receptor (PLA2R) and to a lesser degree (10%), thrombospontin type I domain containing 7A (THSD7A) which are present on podocytes as is megalin in rat models of MN. Similarly, neutral endopeptidase has been found as the target antigen in newborns’ podocytes with alloimmune neonatal membranous nephropathy, cationic bovine serum albumin as a planted antigen in early childhood MN and circulating auto-antibodies against human male antigens. The immunocomplex depositions activate complement, leading to reorganization of podocytic cytoskeleton, elimination of the slit diaphragm proteins and eventually to proteinuria. Additionally intracellural proteins and cryptic epitopes may be exposed, thus inducing “a second wave of immunisation”.Heymann Nephritis is a faithful experimental model of the disease that has been extensively studied since first described by Heymann et al. in 1959. The active model of HN is induced by immunization of Lewis rats with preparations of brush-border proteins. The passive model of HN (PHN) is induced by a single i.v. injection of heterologous anti-brush border antiserum (anti-Fx1A) that produces heterologous IgG subepithelial deposits within hours to days. Proteinuria occurs in all animals within five days. This “heterologous phase” is followed, two weeks later, by an “autologous phase” during which rat IgG antibodies are produced against the heterologous IgG. The autologous IgG alloantibodies are also deposited at the subepithelial space, inducing a further increase in proteinuria. The second (autologous) phase of PHN mimics idiopathic MN because during the autologous phase there is production of autoantibodies, against a planted exogenous antigen but also against neoantigens that are exposed in the subepithelial space during the initial injury. Therefore it is the autologous phase of passive HN that shares the same pathophysiological mechanisms to those recently identified in idiopathic MN in humans.The clinical manifestations of the disease…

Subjects/Keywords: Νεφρίνη; Ποδοσίνη; Ιδιοπαθής μεμβρανώδης σπειραματονερφρίτιδα; Ραπαμυκίνη; Nephrin; Podocin; Idiopathic membranous glomerulonephritis; Rapamycin

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Stratakis, S. (2015). Μελέτη της έκφρασης ποδοκυτταρικών πρωτεϊνών στη μεμβρανώδη σπειραματονεφρίτιδα. (Thesis). University of Crete (UOC); Πανεπιστήμιο Κρήτης. Retrieved from http://hdl.handle.net/10442/hedi/36610

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Stratakis, Stavros. “Μελέτη της έκφρασης ποδοκυτταρικών πρωτεϊνών στη μεμβρανώδη σπειραματονεφρίτιδα.” 2015. Thesis, University of Crete (UOC); Πανεπιστήμιο Κρήτης. Accessed April 10, 2021. http://hdl.handle.net/10442/hedi/36610.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Stratakis, Stavros. “Μελέτη της έκφρασης ποδοκυτταρικών πρωτεϊνών στη μεμβρανώδη σπειραματονεφρίτιδα.” 2015. Web. 10 Apr 2021.

Vancouver:

Stratakis S. Μελέτη της έκφρασης ποδοκυτταρικών πρωτεϊνών στη μεμβρανώδη σπειραματονεφρίτιδα. [Internet] [Thesis]. University of Crete (UOC); Πανεπιστήμιο Κρήτης; 2015. [cited 2021 Apr 10]. Available from: http://hdl.handle.net/10442/hedi/36610.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Stratakis S. Μελέτη της έκφρασης ποδοκυτταρικών πρωτεϊνών στη μεμβρανώδη σπειραματονεφρίτιδα. [Thesis]. University of Crete (UOC); Πανεπιστήμιο Κρήτης; 2015. Available from: http://hdl.handle.net/10442/hedi/36610

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Adelaide

3. Thomson, Napier Maurice. Mechanisms of mediation of allergic glomerular injury.

Degree: 1975, University of Adelaide

URL: http://hdl.handle.net/2440/38440

Subjects/Keywords: Glomerulonephritis

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Thomson, N. M. (1975). Mechanisms of mediation of allergic glomerular injury. (Thesis). University of Adelaide. Retrieved from http://hdl.handle.net/2440/38440

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Thomson, Napier Maurice. “Mechanisms of mediation of allergic glomerular injury.” 1975. Thesis, University of Adelaide. Accessed April 10, 2021. http://hdl.handle.net/2440/38440.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Thomson, Napier Maurice. “Mechanisms of mediation of allergic glomerular injury.” 1975. Web. 10 Apr 2021.

Vancouver:

Thomson NM. Mechanisms of mediation of allergic glomerular injury. [Internet] [Thesis]. University of Adelaide; 1975. [cited 2021 Apr 10]. Available from: http://hdl.handle.net/2440/38440.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Thomson NM. Mechanisms of mediation of allergic glomerular injury. [Thesis]. University of Adelaide; 1975. Available from: http://hdl.handle.net/2440/38440

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

4. Κουτρούλια, Ελένη. Θεραπευτικές παρεμβάσεις στη μεμβρανώδη σπειραματονεφρίτιδα και εκτίμηση της αποτελεσματικότητάς τους με βάση δείκτες εξέλιξης της νόσου.

Degree: 2015, University of Patras

URL: http://hdl.handle.net/10889/8765

►

Η Ιδιοπαθής Μεμβρανώδης Σπειραματονεφρίτιδα (ΙΜΣ) ή νεφροπάθεια, η πιο συχνή αιτία νεφρωσικού συνδρόμου στους ενήλικες, συνήθως αντιμετωπίζεται με τη χορήγηση κορτικοειδών και κυτταροτοξικών φαρμάκων ή… (more)

▼

Η Ιδιοπαθής Μεμβρανώδης Σπειραματονεφρίτιδα (ΙΜΣ) ή νεφροπάθεια, η πιο συχνή αιτία νεφρωσικού συνδρόμου στους ενήλικες, συνήθως αντιμετωπίζεται με τη χορήγηση κορτικοειδών και κυτταροτοξικών φαρμάκων ή κυκλοσπορίνης (cyclosporine-A, CsA). Σκοπός της μελέτης ήταν η εκτίμηση της αποτελεσματικότητας της μακροχρόνιας χορήγησης CsA στην πρόκληση ύφεσης του νεφρωσικού συνδρόμου και των ιστολογικών αλλοιώσεων σε επαναληπτικές βιοψίες νεφρού μετά τη χορήγηση του δυνητικά νεφροτοξικού αυτού φαρμάκου. Επιπλέον, εκτιμήθηκε η αποτελεσματικότητα του Mycophenolate Mofetil (MMF) ως σχήματος θεραπείας της ΙΜΣ σε μικρό αριθμό ασθενών και η προγνωστική αξία των επιπέδων του αυξητικού παράγοντα TGF-β1 στα ούρα και στο πλάσμα ως δεικτών εξέλιξης της νόσου. Μελετήθηκαν 32 ασθενείς με ΙΜΣ οι οποίοι εμφάνιζαν νεφρωσικό σύνδρομο και είχαν ικανοποιητική νεφρική λειτουργία κατά τη διάγνωση της νόσου και στους οποίους χορηγήθηκε συνδυασμός πρεδνιζολόνης και CsA. Παρατηρήθηκε πλήρης ύφεση του νεφρωσικού συνδρόμου σε 18 (56%) και μερική ύφεση σε 10 ασθενείς (31%) μετά από 12 μήνες θεραπείας (συνολικά στο 87% των ασθενών). Επεισόδια υποτροπών παρατηρήθηκαν στο 39% και 60% των ασθενών με πλήρη ή μερική ύφεση αντίστοιχα, και πολλαπλές υποτροπές στο 25% των ασθενών, οι οποίοι παρουσίασαν βαθμιαία μείωση της απαντητικότητας στη CsA και επιδείνωση της νεφρικής λειτουργίας. Επαναληπτική βιοψία νεφρού έγινε σε 18 ασθενείς με ύφεση του νεφρωσικού συνδρόμου μετά από 24 μήνες θεραπείας για να εκτιμηθεί η δραστηριότητα της νόσου και οι πιθανές ιστολογικές αλλοιώσεις σε πλαίσια τοξικότητας από κυκλοσπορίνη. Στις επαναληπτικές βιοψίες παρατηρήθηκαν: εξέλιξη του σταδίου της νόσου, επιδείνωση της σπειραματοσκλήρυνσης και της διαμεσοσωληναριακής βλάβης στο 60% των ασθενών. Δεν παρατηρήθηκαν χαρακτηριστικές αλλοιώσεις νεφροτοξικότητας από την κυκλοσπορίνη. Η βαρύτητα των ιστολογικών αλλαγών συσχετίστηκε με το χρονικό διάστημα που είχε παρέλθει από την πρώτη βιοψία νεφρού (r = 0.452, p < 0.05) και θεωρήθηκε ως φυσική εξέλιξη της νόσου. Ικανοποιητικά αποτελέσματα διαπιστώθηκαν από τη χορήγηση Mycophenolate Mofetil σε 6 ασθενείς με ΙΜΣ, στους οποίους το MMF χρησιμοποιήθηκε σε συνδυασμό με μικρή δόση πρεδνιζολόνης, είτε λόγω ανθεκτικότητας του νεφρωσικού συνδρόμου στην CsA, είτε ως αρχική θεραπεία σε περιπτώσεις αντένδειξης στην χορήγηση CsA. Ύφεση του νεφρωσικού συνδρόμου παρατηρήθηκε σε 4 από τους 6 ασθενείς. Τα επίπεδα του TGF-β1 στα ούρα ασθενών με ΙΜΣ και λευκωματουρία ήταν σημαντικά υψηλότερα συγκριτικά με αυτά υγιών εθελοντών και ασθενών με άλλες σπειραματοπάθειες που δεν παρουσίαζαν λευκωματουρία και μειώθηκαν σημαντικά μετά από χορήγηση κορτικοειδών και κυκλοσπορίνης. Η συγκέντρωση του TGF-β1 στο πλάσμα δε διέφερε σημαντικά μεταξύ υγιών εθελοντών και ασθενών με ΙΜΣ και νεφρωσικό σύνδρομο, καθώς και μεταξύ ασθενών με ή χωρίς ύφεση της λευκωματουρίας μετά από τη θεραπευτική αγωγή.

Idiopathic membranous nephropathy (IMN), the most common cause of nephrotic syndrome in adults, is usually treated with a combination of corticosteroids with cytotoxic…

Advisors/Committee Members: Γούμενος, Δημήτριος, Koutroulia, Eleni, Γούμενος, Δημήτριος, Πασαδάκης, Πλουμής, Φουρτούνας, Κωνσταντίνος, Γώγος, Χαράλαμπος, Μαραγκός, Μάρκος, Σταράκης, Ιωάννης, Παπαχρήστου, Ευάγγελος.

Subjects/Keywords: Σπειραματονεφρίτιδα; Κυκλοσπορίνη; Αυξητικός παράγοντας; Ιδιοπαθής μεμβρανώδης σπειραματονεφρίτιδα (ΙΜΣ); Μυκοφαινολικό οξύ; Νεφρωσικό σύνδρομο; Σπειραματοσκλήρυνση; Πρωτεϊνουρία; 616.612 061; Glomerulonephritis; Cyclosporine; CsA; Transforming growth factor; TGF-b1; Idiopathic membranous nephropathy; MMF; Mycophenolate mofeti; Nefrotic syndrome; Glomerulosclerosis; Proteinuria

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Κουτρούλια, �. (2015). Θεραπευτικές παρεμβάσεις στη μεμβρανώδη σπειραματονεφρίτιδα και εκτίμηση της αποτελεσματικότητάς τους με βάση δείκτες εξέλιξης της νόσου. (Doctoral Dissertation). University of Patras. Retrieved from http://hdl.handle.net/10889/8765

Chicago Manual of Style (16^th Edition):

Κουτρούλια, Ελένη. “Θεραπευτικές παρεμβάσεις στη μεμβρανώδη σπειραματονεφρίτιδα και εκτίμηση της αποτελεσματικότητάς τους με βάση δείκτες εξέλιξης της νόσου.” 2015. Doctoral Dissertation, University of Patras. Accessed April 10, 2021. http://hdl.handle.net/10889/8765.

MLA Handbook (7^th Edition):

Κουτρούλια, Ελένη. “Θεραπευτικές παρεμβάσεις στη μεμβρανώδη σπειραματονεφρίτιδα και εκτίμηση της αποτελεσματικότητάς τους με βάση δείκτες εξέλιξης της νόσου.” 2015. Web. 10 Apr 2021.

Vancouver:

Κουτρούλια �. Θεραπευτικές παρεμβάσεις στη μεμβρανώδη σπειραματονεφρίτιδα και εκτίμηση της αποτελεσματικότητάς τους με βάση δείκτες εξέλιξης της νόσου. [Internet] [Doctoral dissertation]. University of Patras; 2015. [cited 2021 Apr 10]. Available from: http://hdl.handle.net/10889/8765.

Council of Science Editors:

Κουτρούλια �. Θεραπευτικές παρεμβάσεις στη μεμβρανώδη σπειραματονεφρίτιδα και εκτίμηση της αποτελεσματικότητάς τους με βάση δείκτες εξέλιξης της νόσου. [Doctoral Dissertation]. University of Patras; 2015. Available from: http://hdl.handle.net/10889/8765

5. Koutroulia, Eleni. Θεραπευτικές παρεμβάσεις στη μεμβρανώδη σπειραματονεφρίτιδα και εκτίμηση της αποτελεσματικότητάς τους με βάση δείκτες εξέλιξης της νόσου.

Degree: 2015, University of Patras; Πανεπιστήμιο Πατρών

URL: http://hdl.handle.net/10442/hedi/35859

►

Idiopathic membranous nephropathy (IMN), the most common cause of nephrotic syndrome in adults, is usually treated with a combination of corticosteroids with cytotoxic drugs or… (more)

▼

Idiopathic membranous nephropathy (IMN), the most common cause of nephrotic syndrome in adults, is usually treated with a combination of corticosteroids with cytotoxic drugs or cyclosporin A (CsA). The aim of this study was the estimation of the effectiveness of long-term use of CsA in the remission and relapse rate of nephrotic syndrome along with histological changes in repeat renal biopsies after treatment with this potentially nephrotoxic drug, and the evaluation of Mycophenolate Mofetil (MMF) as a treatment regimen for IMN. In addition, urinary and plasma TGF-β1 levels were evaluated as markers of progression of kidney disease.Thirty-two nephrotic patients with well-preserved renal function treated by prednisolone and CsA were studied. Complete remission of nephrotic syndrome was observed in 18 (56%) and partial remission in 10 patients (31%) after 12 months of treatment (total 87%). Relapses were observed in 39% and 60% of patients with complete and partial remission, respectively, and multiple relapses in 25% of patients, who showed gradual unresponsiveness to CsA and decline of renal function. A repeat biopsy was performed in 18 patients with remission of nephrotic syndrome, after 24 months of treatment, to estimate the activity of the disease and features of CsA toxicity. Progression of the stage of the disease, more severe glomerulosclerosis and tubulointerstitial injury were recognized in 60% of patients in repeat renal biopsies. Features of CsA nephrotoxicity were not observed. The severity of histological changes was related to the time elapsed from the first biopsy (r = 0.452, P < 0.05).MMF was proved effective in a small number of nephrotic patients with IMN and well-preserved renal function. MMF in combination with small dose of prednisolone was given in 6 patients with either persistent nephrotic syndrome to CsA or as initial therapy because of contraindication to CsA administration. Remission of nephrotic syndrome was observed in 4 out of 6 MMF treated patients.Urinary and plasma TGF-β1 levels were examined as markers of progression of the disease. TGF-β1 levels in the urine of patients with proteinuria were significantly higher compared with those of healthy individuals and patients with other types of nephropathy without proteinuria. Furthermore, urinary TGF-β1 of nephrotic patients with membranous nephropathy significantly reduced after treatment with CsA and corticosteroids. Plasma TGF-β1 levels showed no difference between patients and healthy subjects as well as between patients with and without remission of proteinuria after treatment.

Η Ιδιοπαθής Μεμβρανώδης Σπειραματονεφρίτιδα (ΙΜΣ) ή νεφροπάθεια, η πιο συχνή αιτία νεφρωσικού συνδρόμου στους ενήλικες, συνήθως αντιμετωπίζεται με τη χορήγηση κορτικοειδών και κυτταροτοξικών φαρμάκων ή κυκλοσπορίνης (cyclosporine-A, CsA). Σκοπός της μελέτης ήταν η εκτίμηση της αποτελεσματικότητας της μακροχρόνιας χορήγησης CsA στην πρόκληση ύφεσης του νεφρωσικού συνδρόμου και των ιστολογικών αλλοιώσεων σε επαναληπτικές βιοψίες νεφρού μετά τη χορήγηση του…

Subjects/Keywords: Σπειραματονεφρίτιδα; Κυκλοσπορίνη; Αυξητικός παράγοντας; Ιδιοπαθής μεμβρανώδης σπειραματονεφρίτιδα; ΙΜΣ; Μυκοφαινολικό οξύ; Νεφρωσικό σύνδρομο; Σπειραματοσκλήρυνση; Πρωτεϊνουρία; Glomerulonephritis; Cyclosporine; CsA; Transforming growth factor; TGF-b1; Idiopathic membranous nephropathy; MMF; Mycophenolate Mofetil; Nefrotic syndrome; Glomerulosclerosis; Proteinuria

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Koutroulia, E. (2015). Θεραπευτικές παρεμβάσεις στη μεμβρανώδη σπειραματονεφρίτιδα και εκτίμηση της αποτελεσματικότητάς τους με βάση δείκτες εξέλιξης της νόσου. (Thesis). University of Patras; Πανεπιστήμιο Πατρών. Retrieved from http://hdl.handle.net/10442/hedi/35859

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Koutroulia, Eleni. “Θεραπευτικές παρεμβάσεις στη μεμβρανώδη σπειραματονεφρίτιδα και εκτίμηση της αποτελεσματικότητάς τους με βάση δείκτες εξέλιξης της νόσου.” 2015. Thesis, University of Patras; Πανεπιστήμιο Πατρών. Accessed April 10, 2021. http://hdl.handle.net/10442/hedi/35859.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Koutroulia, Eleni. “Θεραπευτικές παρεμβάσεις στη μεμβρανώδη σπειραματονεφρίτιδα και εκτίμηση της αποτελεσματικότητάς τους με βάση δείκτες εξέλιξης της νόσου.” 2015. Web. 10 Apr 2021.

Vancouver:

Koutroulia E. Θεραπευτικές παρεμβάσεις στη μεμβρανώδη σπειραματονεφρίτιδα και εκτίμηση της αποτελεσματικότητάς τους με βάση δείκτες εξέλιξης της νόσου. [Internet] [Thesis]. University of Patras; Πανεπιστήμιο Πατρών; 2015. [cited 2021 Apr 10]. Available from: http://hdl.handle.net/10442/hedi/35859.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Koutroulia E. Θεραπευτικές παρεμβάσεις στη μεμβρανώδη σπειραματονεφρίτιδα και εκτίμηση της αποτελεσματικότητάς τους με βάση δείκτες εξέλιξης της νόσου. [Thesis]. University of Patras; Πανεπιστήμιο Πατρών; 2015. Available from: http://hdl.handle.net/10442/hedi/35859

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Toronto

6. Ding, Mei. The Role of Von Hippel-Lindau Protein in the Glomerulus.

Degree: 2010, University of Toronto

URL: http://hdl.handle.net/1807/24342

►

Rapidly progressive glomerulonephritis (RPGN) is a clinical syndrome characterized by loss of renal function within days to weeks and by glomerular crescents on biopsy. The… (more)

▼

Rapidly progressive glomerulonephritis (RPGN) is a clinical syndrome characterized by loss of renal function within days to weeks and by glomerular crescents on biopsy. The pathogenesis of this disease is unclear, but circulating factors such as antineutrophil cytoplasmic antibodies (ANCA) are believed to play a major role. In this thesis, we show that deletion of the Von Hippel-Lindau gene (Vhlh) from intrinsic glomerular cells of mice is sufficient to initiate a necrotizing crescentic glomerulonephritis and the clinical features that accompany RPGN. Loss of Vhlh leads to stabilization of hypoxia-inducible factor alpha subunits (HIFαs). Using gene expression profiling, we identified de novo expression of the HIFα target gene Cxcr4. In glomeruli from mice with RPGN, the course of RPGN is markedly improved in mice treated with a blocking antibody to Cxcr4, whereas overexpression of Cxcr4 alone in podocytes of transgenic mice is sufficient to cause glomerular disease. Despite the development of glomerular disease in mice that overexpress Cxcr4, their disease was milder and lacked features of full-blown RPGN. The Vhlh gene encodes VHL protein (pVHL, product of the Von Hippel-Lindau gene) that functions as the substrate recognition component of an E3 ubiquitin ligase. Although HIFα subunits are the best characterized substrates for pVHL, additional non-HIF mediated targets have been identified. To determine the role of HIF stabilization in this RPGN model, we generated double mutants that lack aryl hydrocarbon receptor nuclear translocator gene (Arnt, also called HIF1beta), an obligate dimerization partner for HIFα subunit function. Podocyte-selective deletion of Arnt in Vhlh mutant mice completely rescued the RPGN phenotype and mice survived longer than 8 months of age. Furthermore, stabilization of HIF2α alone led to glomerular disease characterized by crescentic transformation. Collectively, these results indicate an alternative mechanism for the pathogenesis of RPGN and glomerular disease in an animal model and suggest novel molecular pathways for intervention in this disease. In addition, we demonstrate a key role for VHL-HIF-Cxcr4 molecular pathway for the integrity of the glomerular barrier.

PhD

Advisors/Committee Members: Quaggin, Susan E., Medical Science.

Subjects/Keywords: von Hippel-Lindau gene/protein; Rapidly progressive glomerular nephritis; Podocytes; Hypoxia inducible factors; 0379; 0369; 0307; 0564

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Ding, M. (2010). The Role of Von Hippel-Lindau Protein in the Glomerulus. (Doctoral Dissertation). University of Toronto. Retrieved from http://hdl.handle.net/1807/24342

Chicago Manual of Style (16^th Edition):

Ding, Mei. “The Role of Von Hippel-Lindau Protein in the Glomerulus.” 2010. Doctoral Dissertation, University of Toronto. Accessed April 10, 2021. http://hdl.handle.net/1807/24342.

MLA Handbook (7^th Edition):

Ding, Mei. “The Role of Von Hippel-Lindau Protein in the Glomerulus.” 2010. Web. 10 Apr 2021.

Vancouver:

Ding M. The Role of Von Hippel-Lindau Protein in the Glomerulus. [Internet] [Doctoral dissertation]. University of Toronto; 2010. [cited 2021 Apr 10]. Available from: http://hdl.handle.net/1807/24342.

Council of Science Editors:

Ding M. The Role of Von Hippel-Lindau Protein in the Glomerulus. [Doctoral Dissertation]. University of Toronto; 2010. Available from: http://hdl.handle.net/1807/24342

7. ΠΑΠΑΓΙΑΝΝΗ, ΑΙΚΑΤΕΡΙΝΗ. ΤΟ ΣΥΜΠΛΕΓΜΑ C5B-9 ΤΟΥ ΣΥΜΠΛΗΡΩΜΑΤΟΣ ΚΑΙ ΤΑ ΜΟΡΙΑ ΠΡΟΣΚΟΛΛΗΣΗΣ ΣΤΗΝ ΠΑΘΟΓΕΝΕΙΑ ΤΗΣ ΙΔΙΟΠΑΘΟΥΣ ΜΕΜΒΡΑΝΩΔΟΥΣ ΣΠΕΙΡΑΜΑΤΟΝΕΦΡΙΤΙΔΑΣ. ΜΕΛΕΤΗ ΜΕ ΜΟΝΟΚΛΩΝΙΚΑ ΑΝΤΙΣΩΜΑΤΑ.

Degree: 1997, Democritus University of Thrace (DUTH); Δημοκρίτειο Πανεπιστήμιο Θράκης (ΔΠΘ)

URL: http://hdl.handle.net/10442/hedi/8160

►

THE PATHOGENETIC MECHANISMS OF IDIOPATHIC MEMBRANOUS NEPHROPATHY (IMN) REMAIN LARGELY UNKNOWN. TO THIS PURPOSE, FROSEN KIDNEY SECTIONS FROM 35 PATIENTS WERE STUDIED USING AN INDIRECT… (more)

▼

THE PATHOGENETIC MECHANISMS OF IDIOPATHIC MEMBRANOUS NEPHROPATHY (IMN) REMAIN LARGELY UNKNOWN. TO THIS PURPOSE, FROSEN KIDNEY SECTIONS FROM 35 PATIENTS WERE STUDIED USING AN INDIRECT IMMUNOPEROXIDASE METHOD AND SPECIFIC MONOCLONAL ANTIBODIES. IN THE GLOMERULI, C5B-9 DEPOSITS SHOWED A CORRELATION WITH THE INTENSITY OF IGG AND C3 DEPOSITION. THE STAGE OF THE DISEASE HAD A RELATIONSHIP WITH THE GLOMERULAR VLA-3 EXPRESSION. IN THE TUBULOINTERSTITIUM (TIN), THERE WAS AN ASSOSIATION BETWEEN THE NUMBERS OF INTERSTITIAL T-LYMPHOCYTES, MONOCYTES / MACROPHAGES (MM), HLA-DR(+) AND LFA-1Β(+) CELLS AND THE PERCENTAGE OF TUBULES WITH C5B-Q DEPOSITS. THE EXTENT OF TIN ICAM-I EXPRESSION WAS CORRELATEDWITH THE NUMBERS OF INTERSTITIAL MM, HLA-DR(+) AND LFA-1Β(+) CELLS, AS WELL AS WITH THE EXTENT OF TUBULAR C5B-9 DEPOSITION. THE SEVERITY OF TUBULAR ATROPHY AND INTERSTITIAL FIBROSIS HAD A RELATIONSHIP WITH TUBULAR C5B-9 DEPOSITIONAND ICAM-I EXPRESSION IN THE TIN. THE DEGREE OF PROTEINURIA HAD A CORRELATION WITH THE EXTENT OF TUBULAR VLA-3 EXPRESSION. PLASMA CREATININE (PCR) WAS CORRELATED WITH THE NUMBERS OF INTERSTITIAL T-LYMPHOCYTES, MM, HLA-DR(+) AND LFA-1Β(+) CELLS. MOREOVER, PCR HAD A RELATIONSHIP WITH THE EXTENT OF TUBULARC5B-9 DEPOSITION AND TIN ICAM-I EXPRESSION. IN CONCLUSION, ACTIVATED INTERSTITIAL, BUT NOT GLOMERULAR, MONONUCLEAR CELLS, LFA-1/ ICAM-I INTERACTION, AND C5B-9 DEPOSITION MAY CONTRIBUTE TO THE TIN FIBROSIS AND RENAL FUNCTION IMPAIRMENT IN IMN. PROTEINURIA MAY ALSO LEAD TO INCREASED TUBULAR VLA-3 EXPRESSION.

ΟΙ ΠΑΘΟΓΕΝΕΤΙΚΟΙ ΜΗΧΑΝΙΣΜΟΙ ΣΤΗΝ ΙΔΙΟΠΑΘΗ ΜΕΜΒΡΑΝΩΔΗ ΣΠΕΙΡΑΜΑΤΟΝΕΦΡΙΤΙΔΑ (ΙΜΣΝ) ΠΑΡΑΜΕΝΟΥΝ ΚΑΤΑ ΜΕΓΑΛΟ ΜΕΡΟΣ ΑΓΝΩΣΤΟΙ. ΓΙΑ ΤΟ ΣΚΟΠΟ ΑΥΤΟ ΜΕΛΕΤΗΘΗΚΑΝ ΤΟΜΕΣ ΚΡΥΟΤΟΜΟΥ ΑΠΟ ΒΙΟΨΙΕΣ ΝΕΦΡΟΥ 35 ΑΣΘΕΝΩΝ ΜΕ ΤΗ ΜΕΘΟΔΟ ΤΗΣ ΕΜΜΕΣΗΣ ΑΝΟΣΟΥΠΕΡΟΞΕΙΔΑΣΗΣ ΚΑΙ ΜΕ ΕΙΔΙΚΑ ΜΟΝΟΚΛΩΝΙΚΑ ΑΝΤΙΣΩΜΑΤΑ. ΣΤΑ ΣΠΕΙΡΑΜΑΤΑ ΟΙ ΕΝΑΠΟΘΕΣΕΙΣ C5B-9 ΠΑΡΟΥΣΙΑΣΑΝ ΣΥΣΧΕΤΙΣΗ ΜΕ ΤΙΣ ΕΝΑΠΟΘΕΣΕΙΣ IGG ΚΑΙ C3.ΤΟ ΣΤΑΔΙΟ ΤΗΣ ΝΟΣΟΥ ΠΑΡΟΥΣΙΑΣΕ ΣΥΣΧΕΤΙΣΗ ΜΕ ΤΗΝ ΕΚΦΡΑΣΗ VLA-3 ΣΤΑ ΣΠΕΙΡΑΜΑΤΑ. ΣΤΟ ΔΙΑΜΕΣΟΣΩΛΗΝΑΡΙΑΚΟ ΧΩΡΟ (ΔΕΧ) ΥΠΗΡΧΕ ΣΥΣΧΕΤΙΣΗ ΜΕΤΑΞΥ ΑΡΙΘΜΟΥ Τ-ΛΕΜΦΟΚΥΤΤΑΡΩΝ, ΜΟΝΟΚΥΤΤΑΡΩΝ / ΜΑΚΡΟΦΑΓΩΝ (ΜΜ), HLA-DR(+) KAI LFA-1Β(+) ΚΥΤΤΑΡΩΝ ΚΑΙ ΠΟΣΟΣΤΟΥ ΤΩΝ ΣΩΛΗΝΑΡΙΩΝ ΜΕ ΕΝΑΠΟΘΕΣΕΙΣ C5B-9.Η ΕΚΤΑΣΗ ΕΚΦΡΑΣΗΣ ΙCAM-I ΣΤΟ ΔΕΧ ΠΑΡΟΥΣΙΑΣΕ ΣΥΣΧΕΤΙΣΗ ΜΕ ΤΟΝ ΑΡΙΘΜΟ ΤΩΝ ΜΜ ΚΑΙ HLA-DR(+) ΚΥΤΤΑΡΩΝ ΚΑΙ ΜΕ ΤΗΝ ΕΚΤΑΣΗ ΤΩΝ ΣΩΛΗΝΑΡΙΑΚΩΝ ΕΝΑΠΟΘΕΣΕΩΝ C5B-9. Η ΒΑΡΥΤΗΤΑ ΤΗΣ ΣΩΛΗΝΑΡΙΑΚΗΣ ΑΤΡΟΦΙΑΣ ΚΑΙ ΔΙΑΜΕΣΗΣ ΙΝΩΣΗΣ ΣΧΕΤΙΖΟΤΑΝ ΜΕ ΤΙΣ ΣΩΛΗΝΑΡΙΑΚΕΣ ΕΝΑΠΟΘΕΣΕΙΣ C5B-9 ΚΑΙ ΤΗΝ ΕΚΤΑΣΗ ΕΚΦΡΑΣΗΣ ΙCAM-I ΣΤΟ ΔΕΧ. Η ΒΑΡΥΤΗΤΑ ΤΗΣ ΛΕΥΚΩΜΑΤΟΥΡΙΑΣ ΠΑΡΟΥΣΙΑΣΕ ΣΥΣΧΕΤΙΣΗ ΜΕ ΤΗΝ ΕΚΦΡΑΣΗ VLA-3 ΣΤΑ ΟΥΡΟΦΟΡΑ ΣΩΛΗΝΑΡΙΑ. Η ΚΡΕΑΤΙΝΙΝΗ ΤΟΥ ΟΡΟΥ ΕΜΦΑΝΙΣΕ ΣΥΣΧΕΤΙΣΗΜΕ ΤΑ Τ-ΛΕΜΦΟΚΥΤΤΑΡΑ, ΜΜ, HLA-DR(+) ΚΑΙ LFA-1Β(+) ΚΥΤΤΑΡΑ ΣΤΟ ΔΕΧ, ΚΑΘΩΣ ΚΑΙ ΜΕ ΤΙΣ ΣΩΛΗΝΑΡΙΑΚΕΣ ΕΝΑΠΟΘΕΣΕΙΣ C5B-9 ΚΑΙ ΤΗΝ ΕΚΦΡΑΣΗ ΙCAM-I ΣΤΟ ΔΕΧ. ΣΥΜΠΕΡΑΣΜΑΤΙΚΑ, Η ΔΙΗΘΗΣΗ ΤΟΥ ΔΙΑΜΕΣΟΥ ΙΣΤΟΥ, ΑΛΛΑ ΟΧΙ ΤΩΝ ΣΠΕΙΡΑΜΑΤΩΝ, ΑΠΟ ΕΝΕΡΓΟΠΟΙΗΜΕΝΑ ΜΟΝΟΠΥΡΗΝΑ ΚΥΤΤΑΡΑ, Η ΑΛΛΗΛΕΠΙΔΡΑΣΗ LFA-1/ICAM-I ΚΑΙ Η ΕΝΑΠΟΘΕΣΗ C5B-9 ΦΑΙΝΕΤΑΙ ΟΤΙ ΣΥΜΜΕΤΕΧΟΥΝ ΣΤΗΝ ΑΝΑΠΤΥΞΗ ΤΩΝ ΔΙΑΜΕΣΟΣΩΛΗΝΑΡΙΑΚΩΝ ΒΛΑΒΩΝ…

Subjects/Keywords: Ιδιοπαθής μεμβρανώδης σπειραματονερφρίτιδα; Μονοκύτταρα / Μακροφάγα; Μόρια προσκόλλησης; ΣΥΜΠΛΕΓΜΑ ΣΥΜΠΛΗΡΩΜΑΤΟΣ C5B-9; Τ-λεμφοκύτταρα; Adhesion molecules; COMPLEMENT COMPLEX C5B-9; Idiopathic membranous glomerulonephritis; Monocytes / Macrophages; T-lymphocytes

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

ΠΑΠΑΓΙΑΝΝΗ, . �. (1997). ΤΟ ΣΥΜΠΛΕΓΜΑ C5B-9 ΤΟΥ ΣΥΜΠΛΗΡΩΜΑΤΟΣ ΚΑΙ ΤΑ ΜΟΡΙΑ ΠΡΟΣΚΟΛΛΗΣΗΣ ΣΤΗΝ ΠΑΘΟΓΕΝΕΙΑ ΤΗΣ ΙΔΙΟΠΑΘΟΥΣ ΜΕΜΒΡΑΝΩΔΟΥΣ ΣΠΕΙΡΑΜΑΤΟΝΕΦΡΙΤΙΔΑΣ. ΜΕΛΕΤΗ ΜΕ ΜΟΝΟΚΛΩΝΙΚΑ ΑΝΤΙΣΩΜΑΤΑ. (Thesis). Democritus University of Thrace (DUTH); Δημοκρίτειο Πανεπιστήμιο Θράκης (ΔΠΘ). Retrieved from http://hdl.handle.net/10442/hedi/8160

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

ΠΑΠΑΓΙΑΝΝΗ, ΑΙΚΑΤΕΡΙΝΗ. “ΤΟ ΣΥΜΠΛΕΓΜΑ C5B-9 ΤΟΥ ΣΥΜΠΛΗΡΩΜΑΤΟΣ ΚΑΙ ΤΑ ΜΟΡΙΑ ΠΡΟΣΚΟΛΛΗΣΗΣ ΣΤΗΝ ΠΑΘΟΓΕΝΕΙΑ ΤΗΣ ΙΔΙΟΠΑΘΟΥΣ ΜΕΜΒΡΑΝΩΔΟΥΣ ΣΠΕΙΡΑΜΑΤΟΝΕΦΡΙΤΙΔΑΣ. ΜΕΛΕΤΗ ΜΕ ΜΟΝΟΚΛΩΝΙΚΑ ΑΝΤΙΣΩΜΑΤΑ.” 1997. Thesis, Democritus University of Thrace (DUTH); Δημοκρίτειο Πανεπιστήμιο Θράκης (ΔΠΘ). Accessed April 10, 2021. http://hdl.handle.net/10442/hedi/8160.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

ΠΑΠΑΓΙΑΝΝΗ, ΑΙΚΑΤΕΡΙΝΗ. “ΤΟ ΣΥΜΠΛΕΓΜΑ C5B-9 ΤΟΥ ΣΥΜΠΛΗΡΩΜΑΤΟΣ ΚΑΙ ΤΑ ΜΟΡΙΑ ΠΡΟΣΚΟΛΛΗΣΗΣ ΣΤΗΝ ΠΑΘΟΓΕΝΕΙΑ ΤΗΣ ΙΔΙΟΠΑΘΟΥΣ ΜΕΜΒΡΑΝΩΔΟΥΣ ΣΠΕΙΡΑΜΑΤΟΝΕΦΡΙΤΙΔΑΣ. ΜΕΛΕΤΗ ΜΕ ΜΟΝΟΚΛΩΝΙΚΑ ΑΝΤΙΣΩΜΑΤΑ.” 1997. Web. 10 Apr 2021.

Vancouver:

ΠΑΠΑΓΙΑΝΝΗ �. ΤΟ ΣΥΜΠΛΕΓΜΑ C5B-9 ΤΟΥ ΣΥΜΠΛΗΡΩΜΑΤΟΣ ΚΑΙ ΤΑ ΜΟΡΙΑ ΠΡΟΣΚΟΛΛΗΣΗΣ ΣΤΗΝ ΠΑΘΟΓΕΝΕΙΑ ΤΗΣ ΙΔΙΟΠΑΘΟΥΣ ΜΕΜΒΡΑΝΩΔΟΥΣ ΣΠΕΙΡΑΜΑΤΟΝΕΦΡΙΤΙΔΑΣ. ΜΕΛΕΤΗ ΜΕ ΜΟΝΟΚΛΩΝΙΚΑ ΑΝΤΙΣΩΜΑΤΑ. [Internet] [Thesis]. Democritus University of Thrace (DUTH); Δημοκρίτειο Πανεπιστήμιο Θράκης (ΔΠΘ); 1997. [cited 2021 Apr 10]. Available from: http://hdl.handle.net/10442/hedi/8160.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

ΠΑΠΑΓΙΑΝΝΗ �. ΤΟ ΣΥΜΠΛΕΓΜΑ C5B-9 ΤΟΥ ΣΥΜΠΛΗΡΩΜΑΤΟΣ ΚΑΙ ΤΑ ΜΟΡΙΑ ΠΡΟΣΚΟΛΛΗΣΗΣ ΣΤΗΝ ΠΑΘΟΓΕΝΕΙΑ ΤΗΣ ΙΔΙΟΠΑΘΟΥΣ ΜΕΜΒΡΑΝΩΔΟΥΣ ΣΠΕΙΡΑΜΑΤΟΝΕΦΡΙΤΙΔΑΣ. ΜΕΛΕΤΗ ΜΕ ΜΟΝΟΚΛΩΝΙΚΑ ΑΝΤΙΣΩΜΑΤΑ. [Thesis]. Democritus University of Thrace (DUTH); Δημοκρίτειο Πανεπιστήμιο Θράκης (ΔΠΘ); 1997. Available from: http://hdl.handle.net/10442/hedi/8160

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Michigan State University

8. Rasooly, Linda. Self-reactive polyspecific IgA antibodies in vomitoxin-induced glomerulonephritis.

Degree: PhD, Department of Microbiology and Public Health, 1992, Michigan State University

URL: http://etd.lib.msu.edu/islandora/object/etd:21892

Subjects/Keywords: IgA glomerulonephritis

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Rasooly, L. (1992). Self-reactive polyspecific IgA antibodies in vomitoxin-induced glomerulonephritis. (Doctoral Dissertation). Michigan State University. Retrieved from http://etd.lib.msu.edu/islandora/object/etd:21892

Chicago Manual of Style (16^th Edition):

Rasooly, Linda. “Self-reactive polyspecific IgA antibodies in vomitoxin-induced glomerulonephritis.” 1992. Doctoral Dissertation, Michigan State University. Accessed April 10, 2021. http://etd.lib.msu.edu/islandora/object/etd:21892.

MLA Handbook (7^th Edition):

Rasooly, Linda. “Self-reactive polyspecific IgA antibodies in vomitoxin-induced glomerulonephritis.” 1992. Web. 10 Apr 2021.

Vancouver:

Rasooly L. Self-reactive polyspecific IgA antibodies in vomitoxin-induced glomerulonephritis. [Internet] [Doctoral dissertation]. Michigan State University; 1992. [cited 2021 Apr 10]. Available from: http://etd.lib.msu.edu/islandora/object/etd:21892.

Council of Science Editors:

Rasooly L. Self-reactive polyspecific IgA antibodies in vomitoxin-induced glomerulonephritis. [Doctoral Dissertation]. Michigan State University; 1992. Available from: http://etd.lib.msu.edu/islandora/object/etd:21892

Virginia Tech

9. Hammond, Sarah Elizabeth. Conjugated Linoleic Acid in the treatment of murine autoimmune glomerulonephritis.

Degree: PhD, Biomedical and Veterinary Sciences, 2015, Virginia Tech

URL: http://hdl.handle.net/10919/77384

► Conjugated linoleic acid (CLA) has been shown to reduce inflammation via Peroxisome Proliferator-Activated Receptor (PPAR)-γ in inflammatory disorders such as Crohn's Disease and Inflammatory Bowel… (more)

▼ Conjugated linoleic acid (CLA) has been shown to reduce inflammation via Peroxisome Proliferator-Activated Receptor (PPAR)-γ in inflammatory disorders such as Crohn's Disease and Inflammatory Bowel Disease. We sought to determine whether CLA isomers would reduce inflammation via PPAR-γ in cultured mesangial cells, and in murine models of anti-glomerular basement membrane (anti-GBM) glomerulonephritis and Systemic Lupus Erythematosus (SLE). SV40-transformed mouse mesangial cells (MES13) were cultured with pure CLA isomers (c9,t11 or t10,c12-CLA or a 50:50 mixture prior to immune stimulation with lipopolysaccharide and interferon-γ. Next, cultured mesangial cells were transfected with small interfering RNA (siRNA) targeting PPAR-γ and treated with CLA isomers prior to immune stimulation. ELISA, qPCR, Western blot, and Griess reaction were performed to measure cytokine production, mRNA expression, induced nitric oxide synthase (iNOS) and nitrite production, respectively. Next, myeloid-specific (LysM creR2+) PPAR-γ knockout mice were treated with CLA prior to the induction of anti-GBM glomerulonephritis and evaluated for disease. Finally, NZM2410/J mice (a natural model of SLE) were treated with c9,t11-CLA and evaluated for disease progression. Treatment with CLA reduced IL-6 production in cultured mesangial cells, but not in siRNA-treated mesangial cells, supporting a PPAR-γ-mediated mechanism. CLA treatment increased both Transforming Growth Factor (TGF-β) and Interleukin-1 Receptor Antagonist (IL-1RA) mRNA expression independent of PPAR – γ. While CLA treatment reduced nitrite production and iNOS production to some degree, this was an inconsistent finding. Conversely, in the induced anti-GBM mouse model, CLA treatment increased mesangial cell IL-6 mRNA expression, reduced TGF-β expression, and had no effect on IL-1RA. Moreover, NZM2410/J mice that were fed a c9,t11-CLA-supplemented diet had reduced survival times, increased renal inflammation and increased serum IgG2a relative to controls. Taken together, these studies indicate that the in vitro MES13 cell line does not translate to the in vivo mouse model of anti-GBM induced glomerulonephritis. Furthermore, while CLA may have beneficial effects in other mouse models, it worsens disease in NZM2410/J mice. Findings from these models should be interpreted with caution. Advisors/Committee Members: LeRoith, Tanya (committeechair), Prater, Mary R. (committee member), Liu, Dongmin (committee member), Schurig, Gerhardt G. (committee member), Hontecillas-Magarzo, Raquel (committee member).

Subjects/Keywords: SLE; glomerulonephritis; murine; autoimmune; lupus

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Hammond, S. E. (2015). Conjugated Linoleic Acid in the treatment of murine autoimmune glomerulonephritis. (Doctoral Dissertation). Virginia Tech. Retrieved from http://hdl.handle.net/10919/77384

Chicago Manual of Style (16^th Edition):

Hammond, Sarah Elizabeth. “Conjugated Linoleic Acid in the treatment of murine autoimmune glomerulonephritis.” 2015. Doctoral Dissertation, Virginia Tech. Accessed April 10, 2021. http://hdl.handle.net/10919/77384.

MLA Handbook (7^th Edition):

Hammond, Sarah Elizabeth. “Conjugated Linoleic Acid in the treatment of murine autoimmune glomerulonephritis.” 2015. Web. 10 Apr 2021.

Vancouver:

Hammond SE. Conjugated Linoleic Acid in the treatment of murine autoimmune glomerulonephritis. [Internet] [Doctoral dissertation]. Virginia Tech; 2015. [cited 2021 Apr 10]. Available from: http://hdl.handle.net/10919/77384.

Council of Science Editors:

Hammond SE. Conjugated Linoleic Acid in the treatment of murine autoimmune glomerulonephritis. [Doctoral Dissertation]. Virginia Tech; 2015. Available from: http://hdl.handle.net/10919/77384

Freie Universität Berlin

10. Martini, Sebastian. Effects of the lymphocyte modulator FTY720 on acute and chronic anti- thy1-induced renal matrix expansion.

Degree: 2006, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-14377

► Glomerulonephritis is a major cause of chronic renal disease and end-stage renal failure. With regard to tissue inflammation most chronic kidney disorders are characterized by… (more)

▼ Glomerulonephritis is a major cause of chronic renal disease and end-stage renal failure. With regard to tissue inflammation most chronic kidney disorders are characterized by a prominent round cell infiltration consisting of macrophages and lymphocytes. To test the hypothesis that lymphocytes participate actively in pathogenesis and progression of acute and chronic renal disease, rats with anti-thy1-induced acute glomerulonephritis and anti- thy1-induced chronic glomerulosclerosis were treated with the novel selective lymphocyte inhibitor FTY720. The actions of FTY720 on markers of tissue fibrosis such as transforming growth factor-ß (TGF-ß), fibronectin and plasminogen activator inhibitor-1 (PAI-1) 7 days after induction of acute anti-thy1-glomerulonephritis (protocol 2) as well as 20 weeks after induction of chronic anti-thy1-glomerulosclerosis (protocol 3) were analyzed. Both glomerular and tubulointerstitial matrix accumulation were determined by scoring matrix expansion histologically. In addition parameters of mesangial cell lysis and glomerular NO-production after a 5 day pre-treatment with FTY720 in acute anti-thy1-glomerulonephritis (protocol 1) were measured. In protocol 1 it was shown, that in acute anti-thy1-glomerulonephritis FTY720-induced lymphocyte inhibition had no significant effects on parameters of mesangial cell lysis and glomerular NO-production. In protocol 2 FTY720-induced lymphocyte inhibition resulted in a significant reduction in renal matrix expansion, protein expression of TGF-ß, fibronectin and PAI-1 as well as in proteinuria. Progression of anti-thy1-glomerulosclerosis was characterized by a marked increase in tubulointerstitial matrix score and cortical protein expression of TGF-ß, fibronection and PAI-1. In protocol 3 treatment with FTY720 largely prevented the disease progression of chronic anti-thy1 glomerulosclerosis towards tubulointerstitial and glomerular fibrosis and renal insufficiancy. The most prominent actions of FTY720 on renal matrix accumulation were observed in the tubulointerstital compartment. The histologic benefits from FTY720 were paralleled by improvement of proteinuria and markers of renal function. FTY720 treatment significantly prevented renal infiltration with CD4-positive and CD8-positive cells. Since progression in other renal disease such as hypertensive and diabetic nephropathy shows a prominent lymphocyte infiltration, FTY720 might be beneficial in these diseases as well. Expanding this perspective, not only chronic renal diseases but fibrotic diseases of other organs such as heart, lung, liver and circulation are histologically characterized by an infiltration with lymphocytes. The therapeutic potential of FTY720 in prevention of chronic organ failure of these organs warrants further investigation. Advisors/Committee Members: n (gender), Prof. Dr. med. H. Peters (firstReferee), Prof. Dr. med. M. van der Giet (furtherReferee), Prof. Dr. med. F. Strutz (furtherReferee).

Subjects/Keywords: FTY720; lymphocytes; acute anti-thy1-glomerulonephritis; chronic progressive anti-thy1-glomerulosclerosis; 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Martini, S. (2006). Effects of the lymphocyte modulator FTY720 on acute and chronic anti- thy1-induced renal matrix expansion. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-14377

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Martini, Sebastian. “Effects of the lymphocyte modulator FTY720 on acute and chronic anti- thy1-induced renal matrix expansion.” 2006. Thesis, Freie Universität Berlin. Accessed April 10, 2021. http://dx.doi.org/10.17169/refubium-14377.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Martini, Sebastian. “Effects of the lymphocyte modulator FTY720 on acute and chronic anti- thy1-induced renal matrix expansion.” 2006. Web. 10 Apr 2021.

Vancouver:

Martini S. Effects of the lymphocyte modulator FTY720 on acute and chronic anti- thy1-induced renal matrix expansion. [Internet] [Thesis]. Freie Universität Berlin; 2006. [cited 2021 Apr 10]. Available from: http://dx.doi.org/10.17169/refubium-14377.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Martini S. Effects of the lymphocyte modulator FTY720 on acute and chronic anti- thy1-induced renal matrix expansion. [Thesis]. Freie Universität Berlin; 2006. Available from: http://dx.doi.org/10.17169/refubium-14377

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Lund

11. Melander Skattum, Lillemor. Complement aberrations and autoantibodies to complement proteins in relation to disease mechanisms.

Degree: 2008, University of Lund

URL: https://lup.lub.lu.se/record/1058268 ; https://portal.research.lu.se/ws/files/3895861/1058340.pdf

► The complement system, a part of the innate immune system with several links to the adaptive immune system, plays an important role in the pathogenesis… (more)

▼ The complement system, a part of the innate immune system with several links to the adaptive immune system, plays an important role in the pathogenesis of many diseases. The purpose of this thesis was to document and clarify some of these mechanisms. The thesis is based on four papers (I-IV). (I and II) Autoantibodies to the C3 cleaving enzyme complex of the alternative pathway, C3 nephritic factors (C3 NeF), cause partial C3 deficiency and are associated with increased susceptibility to bacterial infections. By analysis of samples from 20 patients with C3 NeF, it was confirmed that C3 NeF are of at least 2 types; one with fluid phase (C3 NeF type I) and one with solid phase (C3 NeF type II) activity. Different types of C3 NeF were associated with different serum complement profiles and symptoms. Only C3 NeF type II were found to be associated with circulating autoantibodies to the collagenous region of C1q (aC1qCLR). Defense against Neisseria meningitidis in 26 patients with low C3 concentrations due to C3 NeF was investigated. In patients and control children, homozygosity for the IgG1 and IgG3 IGHG alleles G1M*f and G3M*b was found to be associated with higher serum bactericidal activity (SBA) than was heterozygosity. IGHG alleles correlated to IgG subclass binding to live meningococci, while IgG subclass binding did not correlate to SBA. Thus, the mechanism of influence from IGHG genes on SBA is unclear. IGHG variants are important for immune defense against meningococci in states of deficient complement function. This relationship should be examined further. (III) Serum levels of mannan-binding lectin (MBL) and antibodies to proteins from a potentially nephritogenic Streptococcus pyogenes strain (serotype M1 strain AP1) were investigated in 73 patients with acute poststreptococcal glomerulonephritis (AGN). Antibody responses to the serotype M1-related antigens M1, protein H and streptococcal inhibitor of complement were increased in patients compared to controls. The presence of MBL deficient individuals (serum concentration <0.1 mg/L) among AGN patients showed that the lectin pathway is not required in the pathogenesis of AGN. (IV) Autoimmunity has been implied to participate in the pathogenesis of idiopathic sudden hearing loss (ISHL). Autoantibodies were analysed in sera from 92 patients with ISHL. The most frequently occurring antibody was aC1qCLR, detected in 12 patients (13 %), all with normal serum concentrations of C1q. In ISHL, aC1qCLR probably represents cross-reactivity between C1q and inner ear protein(s).

Subjects/Keywords: Immunology in the medical area; Microbiology in the medical area; C3 nephritic factors; GM allotypes; C1q autoantibodies; serum bactericidal activity; Neisseria meningitidis; idiopathic sudden hearing loss; complement; Acute poststreptococcal glomerulonephritis

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Melander Skattum, L. (2008). Complement aberrations and autoantibodies to complement proteins in relation to disease mechanisms. (Doctoral Dissertation). University of Lund. Retrieved from https://lup.lub.lu.se/record/1058268 ; https://portal.research.lu.se/ws/files/3895861/1058340.pdf

Chicago Manual of Style (16^th Edition):

Melander Skattum, Lillemor. “Complement aberrations and autoantibodies to complement proteins in relation to disease mechanisms.” 2008. Doctoral Dissertation, University of Lund. Accessed April 10, 2021. https://lup.lub.lu.se/record/1058268 ; https://portal.research.lu.se/ws/files/3895861/1058340.pdf.

MLA Handbook (7^th Edition):

Melander Skattum, Lillemor. “Complement aberrations and autoantibodies to complement proteins in relation to disease mechanisms.” 2008. Web. 10 Apr 2021.

Vancouver:

Melander Skattum L. Complement aberrations and autoantibodies to complement proteins in relation to disease mechanisms. [Internet] [Doctoral dissertation]. University of Lund; 2008. [cited 2021 Apr 10]. Available from: https://lup.lub.lu.se/record/1058268 ; https://portal.research.lu.se/ws/files/3895861/1058340.pdf.

Council of Science Editors:

Melander Skattum L. Complement aberrations and autoantibodies to complement proteins in relation to disease mechanisms. [Doctoral Dissertation]. University of Lund; 2008. Available from: https://lup.lub.lu.se/record/1058268 ; https://portal.research.lu.se/ws/files/3895861/1058340.pdf

12. 예, 영민. Increased epidermal filaggrin in chronic idiopathic urticaria is associated with severity of urticaria.

Degree: 2015, Ajou University

URL: http://repository.ajou.ac.kr/handle/201003/11897 ; http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000018988

국문요약 i 차례 iⅱ 그림차례 iv 표차례 v Ⅰ. 서론 1 Ⅱ. 연구대상 및 방법 3 Ⅲ. 결과 8 Ⅳ. 고찰 13 Ⅴ. 결론 19 참고문헌 20 ABSTRACT 27

Doctor

Advisors/Committee Members: 대학원 의학과, 200524472, 예, 영민.

Subjects/Keywords: Chronic idiopathic urticaria

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

예, �. (2015). Increased epidermal filaggrin in chronic idiopathic urticaria is associated with severity of urticaria. (Thesis). Ajou University. Retrieved from http://repository.ajou.ac.kr/handle/201003/11897 ; http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000018988

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

예, 영민. “Increased epidermal filaggrin in chronic idiopathic urticaria is associated with severity of urticaria.” 2015. Thesis, Ajou University. Accessed April 10, 2021. http://repository.ajou.ac.kr/handle/201003/11897 ; http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000018988.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

예, 영민. “Increased epidermal filaggrin in chronic idiopathic urticaria is associated with severity of urticaria.” 2015. Web. 10 Apr 2021.

Vancouver:

예 �. Increased epidermal filaggrin in chronic idiopathic urticaria is associated with severity of urticaria. [Internet] [Thesis]. Ajou University; 2015. [cited 2021 Apr 10]. Available from: http://repository.ajou.ac.kr/handle/201003/11897 ; http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000018988.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

예 �. Increased epidermal filaggrin in chronic idiopathic urticaria is associated with severity of urticaria. [Thesis]. Ajou University; 2015. Available from: http://repository.ajou.ac.kr/handle/201003/11897 ; http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000018988

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of New South Wales

13. Amato, Lisa Anne. An investigation into increased cases of idiopathic infantile hypercalcaemia.

Degree: Women's & Children's Health, 2019, University of New South Wales

URL: http://handle.unsw.edu.au/1959.4/70136 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:72055/SOURCE02?view=true

► Following increased presentations for idiopathic infantile hypercalcaemia (IIH) between 2011 and 2014, we hypothesized that antenatal vitamin D supplementation might be associated with increased calcaemia… (more)

▼ Following increased presentations for idiopathic infantile hypercalcaemia (IIH) between 2011 and 2014, we hypothesized that antenatal vitamin D supplementation might be associated with increased calcaemia in infancy, and hypercalcaemia in susceptible infants. We examined the biochemical profile and response to treatment of 14 patients presenting at median age 17 days [range 5-53] managed for IIH, and the diagnostic utility of a panel of genes involved in calcium sensing or vitamin D metabolism (CASR, AP2S1, GNAll, CYP24Al). Using a laboratory-based population under the age of 6 months, we examined the trend in calcaemia, the prevalence of hyper- and hypocalcaemia, the frequency of 25 hydroxyvitamin D (25OHD) testing and levels of sufficiency over a 12 year period Biochemistry of the 14 infants was consistent with variations in vitamin D metabolism and/or calcium sensing and antenatal vitamin D supplementation was common; however no pathogenic genetic variants were identified in 9 infants studied. All infants responded to low calcium feed; however prolonged use was associated with high parathyroid hormone (PTH) and low 25OHD in most infants, despite total calcium concentrations in the upper part of the reference range. Examining separate laboratory datasets for total (n= 26765) and ionised (n=83228) calcium measurements identified increased hypercalcaemia, decreased hypocalcaemia and a gradual rise in both total and ionised calcaemia over 12 years. The frequency of 25OHD testing increased but concentrations and the number of values >50nmol/L did not. There was no correlation between paired calcium and 25OHD concentrations.Our findings suggest that single variations in the genes studied are unlikely to explain IIH in the majority of infants, despite biochemical evidence of variations in calcium sensing and/or vitamin D metabolism. The rise of PTH associated with prolonged low calcium feeds may have a deleterious effect on bone health and should be monitored closely. A contribution of antenatal vitamin D supplementation to the increase in calcaemia and hypercalcaemia observed remains plausible but was not supported by increased 25OHD concentrations. Given the broad range of calcaemia associated with 25OHD concentrations well below 50nmol/l however, we question whether an isolated 25OHD concentration is a robust marker of vitamin D action.

Subjects/Keywords: Idiopathic infantile hypercalcaemia

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Amato, L. A. (2019). An investigation into increased cases of idiopathic infantile hypercalcaemia. (Masters Thesis). University of New South Wales. Retrieved from http://handle.unsw.edu.au/1959.4/70136 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:72055/SOURCE02?view=true

Chicago Manual of Style (16^th Edition):

Amato, Lisa Anne. “An investigation into increased cases of idiopathic infantile hypercalcaemia.” 2019. Masters Thesis, University of New South Wales. Accessed April 10, 2021. http://handle.unsw.edu.au/1959.4/70136 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:72055/SOURCE02?view=true.

MLA Handbook (7^th Edition):

Amato, Lisa Anne. “An investigation into increased cases of idiopathic infantile hypercalcaemia.” 2019. Web. 10 Apr 2021.

Vancouver:

Amato LA. An investigation into increased cases of idiopathic infantile hypercalcaemia. [Internet] [Masters thesis]. University of New South Wales; 2019. [cited 2021 Apr 10]. Available from: http://handle.unsw.edu.au/1959.4/70136 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:72055/SOURCE02?view=true.

Council of Science Editors:

Amato LA. An investigation into increased cases of idiopathic infantile hypercalcaemia. [Masters Thesis]. University of New South Wales; 2019. Available from: http://handle.unsw.edu.au/1959.4/70136 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:72055/SOURCE02?view=true

14. Kamma, Ioanna. Μελέτη της υποουλικής μικροβιακής χλωρίδας ασθενών με ταχέως εξελισσόμενη περιοδοντίτιδα.

Degree: 1989, National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ)

URL: http://hdl.handle.net/10442/hedi/1215

► Subgingival plaque samples were taken from 142 diseased subgingival sites exhibiting attachment loss >6mm, between 4mm and 6mm and <4mm in 10 young adults ranging… (more)

▼ Subgingival plaque samples were taken from 142 diseased subgingival sites exhibiting attachment loss >6mm, between 4mm and 6mm and <4mm in 10 young adults ranging in age from 25 to 35 years with rapidly progressive periodontitis. The samples were placed in 0.9 ml of prereducedanaerobically sterilized R.T.F., dispersed, diluted and plated on selective (T.S.A.B.) and non-selective (E.T.S.A.) media. After 7 days of anaerobic incubation, isolates were picked, subcultured, characterized and identified to the species level. The purpose of the: present investigation was to determine the predominant species in each group of periodontal lesions in relation to attachmentlevel and to reveal the differences and variability within the three clinically different periodontal lesions. As it is well known that the destruction of periodontal tissues progresses with periods of exacerbation and remission, an attempt was made to relate microbial species to these periods of disease activity. Active diseased sites comprised the sites showing increased attachment lossbetween two consecutive clinical measurments and inactive the sites showing no changes in attachment level during the same time. The results supported the following conclusions: 1. The consistent isolation of the bacterial species B. gingivalis, F. nucleatum, Fusiform bacteroides, W. recta, C. sputorum, S. sputigena, P. micros, E. alactolyticum, A. actinomycetemcomitans, E. corrodens and A israelii from the subgingival plaque samples of periodontal lesions exhibitingattachment loss > 6mm confirms further the earlier aspects that these bacterial species may be the etiologic agents of the periodontal destruction, since they have been shown to have pathogenic potential and produce virulence factors. These bacterial species either along or in combinations seems very probable to relate to the periodontal destruction and to rapidly progressive periodontitis. 2. The qualitative and quantitative differences detected in the bacterial flora between the two groups of clinically distinct periodontal lesions, severe and intermediate, revealed a variability within the microflora according to the clinical features of the periodontal lesions. 3. The bacterial flora of lesions showing attachment loss < 4mm was characterized by the consistent isolation of A. viscosus, A. naeslundii. A. propionica, C. gingivalis, H. segnis, H. aphrophi!us,H. paraphrophilus andP. acnes and the decrease of pathogenic microbiota respectively. These bacterial species appear to confer protection or they are at least compatible to a stable periodontal status. 4. B. gingivalis, F. nucleatum, Fusiform bacteroides, W. recta and C. sputorum were detected more frequently and in higher levels in active sites showing a strong correlation with active periodontal lesions. 5. A naeslundii, A. viscosus, H. segnis, L. buccalis and V. parvula were found more often and in higher levels in inactive sites showing a strong correlation with inactive periodontal lesions. These species appear to lessen the chance of a site being active…

Subjects/Keywords: Ανενεργές περιοδοντικές βλάβες; Απώλεια πρόσφυσης; Ενεργές περιοδοντικές βλάβες; Περιοπαθογόνα βακτήρια; Ταχέως εξελισσόμενη περιοδοντίτιδα; Υποουλική μικροβιακή χλωρίδα; Active periodontal lesions; Inactive periodontal lesions; Loss of attachment; Periopathogenic bacteria; Rapidly progressive periodontitis; Subgingival microflora

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Kamma, I. (1989). Μελέτη της υποουλικής μικροβιακής χλωρίδας ασθενών με ταχέως εξελισσόμενη περιοδοντίτιδα. (Thesis). National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ). Retrieved from http://hdl.handle.net/10442/hedi/1215

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Kamma, Ioanna. “Μελέτη της υποουλικής μικροβιακής χλωρίδας ασθενών με ταχέως εξελισσόμενη περιοδοντίτιδα.” 1989. Thesis, National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ). Accessed April 10, 2021. http://hdl.handle.net/10442/hedi/1215.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Kamma, Ioanna. “Μελέτη της υποουλικής μικροβιακής χλωρίδας ασθενών με ταχέως εξελισσόμενη περιοδοντίτιδα.” 1989. Web. 10 Apr 2021.

Vancouver:

Kamma I. Μελέτη της υποουλικής μικροβιακής χλωρίδας ασθενών με ταχέως εξελισσόμενη περιοδοντίτιδα. [Internet] [Thesis]. National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ); 1989. [cited 2021 Apr 10]. Available from: http://hdl.handle.net/10442/hedi/1215.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Kamma I. Μελέτη της υποουλικής μικροβιακής χλωρίδας ασθενών με ταχέως εξελισσόμενη περιοδοντίτιδα. [Thesis]. National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ); 1989. Available from: http://hdl.handle.net/10442/hedi/1215

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Vanderbilt University

15. Gabriel, Curtis Lee. The interplay between diet, metabolism and autoimmunity in the B6.SLE mouse model of systemic lupus erythematosus.

Degree: PhD, Pathology, 2013, Vanderbilt University

URL: http://hdl.handle.net/1803/10692

► Systemic lupus erythematosus (SLE) patients are at increased risk of developing components of the metabolic syndrome. Furthermore, obesity and high-fat diet (HFD) can lead to… (more)

▼ Systemic lupus erythematosus (SLE) patients are at increased risk of developing components of the metabolic syndrome. Furthermore, obesity and high-fat diet (HFD) can lead to SLE nephritis exacerbation in humans and mouse models. Study of the interplay between metabolic dysfunction and autoimmunity may inform the care of SLE patients. Chapter one of this thesis provides background on the fields of systemic lupus erythematosus and the metabolic syndrome, and highlights the shared pathogenic mechanisms that may instigate these diseases. Chapter two describes efforts to characterize the development of glucose homeostasis in the lupus-prone B6.SLE strain of mice. We show that B6.SLE mice have significantly worsened glucose tolerance and adipose tissue insulin resistance than B6 controls. This B6.SLE glucose intolerance occurs in the presence of a diabetogenic B cell environment which is characterized by the presence of an increased number of IgG-producing B cells and IgG depositions in the white adipose tissue as well as higher levels of circulating IgG. Most interestingly, this strain of mice develops glucose intolerance and adipose tissue insulin resistance in an adiposity-independent manner, indicating that this strain may be a valid model for insulin resistance in the SLE patient population. These studies provide data that elucidate the pathogenesis of insulin resistance in SLE patients and may provide greater insight into the development of insulin resistance in the obese population. Chapter three shows that high-fat diet feeding does not significantly worsen glomerulonephritis or kidney function in B6.SLE mice. Although this finding is in conflict with earlier studies of SLE models, it is possible that changes in study design could reveal dietary factors that exacerbate or ameliorate disease in the B6.SLE mouse model. Chapter four compares our results to those of other studies in SLE model models and SLE patients and proposes a mechanism for the pathogenesis of glucose intolerance and insulin resistance in the B6.SLE mouse model. Advisors/Committee Members: Larry L. Swift (committee member), Virginia L. Shepherd (committee member), Alyssa H. Hasty, Ph.D. (committee member), David H. Wasserman, Ph.D. (committee member), W. Gray Jerome, Ph.D. (Committee Chair).

Subjects/Keywords: SLE; insulin resistance; metabolic syndrome; lupus; glomerulonephritis

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Gabriel, C. L. (2013). The interplay between diet, metabolism and autoimmunity in the B6.SLE mouse model of systemic lupus erythematosus. (Doctoral Dissertation). Vanderbilt University. Retrieved from http://hdl.handle.net/1803/10692

Chicago Manual of Style (16^th Edition):

Gabriel, Curtis Lee. “The interplay between diet, metabolism and autoimmunity in the B6.SLE mouse model of systemic lupus erythematosus.” 2013. Doctoral Dissertation, Vanderbilt University. Accessed April 10, 2021. http://hdl.handle.net/1803/10692.

MLA Handbook (7^th Edition):

Gabriel, Curtis Lee. “The interplay between diet, metabolism and autoimmunity in the B6.SLE mouse model of systemic lupus erythematosus.” 2013. Web. 10 Apr 2021.

Vancouver:

Gabriel CL. The interplay between diet, metabolism and autoimmunity in the B6.SLE mouse model of systemic lupus erythematosus. [Internet] [Doctoral dissertation]. Vanderbilt University; 2013. [cited 2021 Apr 10]. Available from: http://hdl.handle.net/1803/10692.

Council of Science Editors:

Gabriel CL. The interplay between diet, metabolism and autoimmunity in the B6.SLE mouse model of systemic lupus erythematosus. [Doctoral Dissertation]. Vanderbilt University; 2013. Available from: http://hdl.handle.net/1803/10692

University of Texas Southwestern Medical Center

16. Gutierrez, Maria Antonietta. Role of Bruton’s Tyrosine Kinase and Interleukin-6 in Plasma Cell Accumulation and Autoantibody Production in Lyn-Deficient Mice, A Model of Lupus.

Degree: 2011, University of Texas Southwestern Medical Center

URL: http://hdl.handle.net/2152.5/881

► Systemic lupus erythematosus (SLE) is characterized by loss of tolerance to nuclear antigens such as DNA and chromatin, resulting in autoantibody production, immune complex deposition,… (more)

▼ Systemic lupus erythematosus (SLE) is characterized by loss of tolerance to nuclear antigens such as DNA and chromatin, resulting in autoantibody production, immune complex deposition, inflammation, and end organ damage such as glomerulonephritis (GN). Currently, only non-specific, immunosuppressive therapies are approved for use in lupus patients. These have undesirable side effects and risks. The development of more targeted therapies is necessary and requires a better understanding of the mechanisms that contribute to the production of autoantibodies. Mice deficient in Lyn, a gene associated with human lupus, develop several features characteristic of SLE, including peripheral plasma cell accumulation, anti-dsDNA antibodies, and GN. Lyn is a Src-family tyrosine kinase that, in general, inhibits B cell and myeloid cell activity. Loss of Lyn results in cellular hyperactivity associated with autoantibody production. Bruton’s tyrosine kinase (Btk), which is critical to B cell receptor (BCR) signaling, mediates BCR hypersensitivity and autoantibody production in lyn-/- mice. B cell hyperresponsiveness is not, however, sufficient for the autoimmune phenotype; additional Btk-dependent events are required. Btk also contributes to myeloid cell function, and generally opposes Lyn action in these cells as in B cells. However, the relative contribution of myeloid hyperactivity to autoantibody production in lyn-/- mice is unknown. Lyn-deficient mice expressing reduced Btk dosage in B cells and no Btk in myeloid cells were utilized to better define how Lyn and Btk regulate and mediate, respectively, the progression from tolerance to autoimmunity. Two major checkpoints regulating autoantibody production were identified and found to be breached in lyn-/- mice. The first checkpoint regulates Btk-mediated accumulation of long-lived plasma cells co-incident with polyclonal IgM autoreactivity. This is due in part to impaired migration of lyn-/- plasma cells towards SDF-1 and involves a B cell intrinsic effect of Lyn-deficiency. The second checkpoint regulates the class-switching of B cells with lupus-associated autoantigen specificities and the production of pathogenic autoantibodies. This step requires IL-6, which is produced in excess by lyn-/- myeloid cells in a Btk-dependent manner. These results suggest that both B and myeloid defects contribute to autoimmunity in lyn-/- mice and identify Btk and IL-6 as potential therapeutic targets for SLE. Advisors/Committee Members: Satterthwaite, Anne B..

Subjects/Keywords: Lupus Erythematosus, Systemic; Protein-Tyrosine Kinases; Glomerulonephritis

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Gutierrez, M. A. (2011). Role of Bruton’s Tyrosine Kinase and Interleukin-6 in Plasma Cell Accumulation and Autoantibody Production in Lyn-Deficient Mice, A Model of Lupus. (Thesis). University of Texas Southwestern Medical Center. Retrieved from http://hdl.handle.net/2152.5/881

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Gutierrez, Maria Antonietta. “Role of Bruton’s Tyrosine Kinase and Interleukin-6 in Plasma Cell Accumulation and Autoantibody Production in Lyn-Deficient Mice, A Model of Lupus.” 2011. Thesis, University of Texas Southwestern Medical Center. Accessed April 10, 2021. http://hdl.handle.net/2152.5/881.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Gutierrez, Maria Antonietta. “Role of Bruton’s Tyrosine Kinase and Interleukin-6 in Plasma Cell Accumulation and Autoantibody Production in Lyn-Deficient Mice, A Model of Lupus.” 2011. Web. 10 Apr 2021.

Vancouver:

Gutierrez MA. Role of Bruton’s Tyrosine Kinase and Interleukin-6 in Plasma Cell Accumulation and Autoantibody Production in Lyn-Deficient Mice, A Model of Lupus. [Internet] [Thesis]. University of Texas Southwestern Medical Center; 2011. [cited 2021 Apr 10]. Available from: http://hdl.handle.net/2152.5/881.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Gutierrez MA. Role of Bruton’s Tyrosine Kinase and Interleukin-6 in Plasma Cell Accumulation and Autoantibody Production in Lyn-Deficient Mice, A Model of Lupus. [Thesis]. University of Texas Southwestern Medical Center; 2011. Available from: http://hdl.handle.net/2152.5/881

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Adelaide

17. Woodroffe, Andrew John. The detection and characterization of immune complexes in glomerulonephritis.

Degree: 1977, University of Adelaide

URL: http://hdl.handle.net/2440/38463

Subjects/Keywords: Glomerulonephritis Immunological aspects.

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Woodroffe, A. J. (1977). The detection and characterization of immune complexes in glomerulonephritis. (Thesis). University of Adelaide. Retrieved from http://hdl.handle.net/2440/38463

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Woodroffe, Andrew John. “The detection and characterization of immune complexes in glomerulonephritis.” 1977. Thesis, University of Adelaide. Accessed April 10, 2021. http://hdl.handle.net/2440/38463.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Woodroffe, Andrew John. “The detection and characterization of immune complexes in glomerulonephritis.” 1977. Web. 10 Apr 2021.

Vancouver:

Woodroffe AJ. The detection and characterization of immune complexes in glomerulonephritis. [Internet] [Thesis]. University of Adelaide; 1977. [cited 2021 Apr 10]. Available from: http://hdl.handle.net/2440/38463.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Woodroffe AJ. The detection and characterization of immune complexes in glomerulonephritis. [Thesis]. University of Adelaide; 1977. Available from: http://hdl.handle.net/2440/38463

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Cape Town

18. Zent, Roy. Rapidly progressive glomerulonephritis at Groote Schuur hospital.

Degree: Image, Medicine, 1992, University of Cape Town

URL: http://hdl.handle.net/11427/25732

Subjects/Keywords: Glomerulonephritis - South Africa

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Zent, R. (1992). Rapidly progressive glomerulonephritis at Groote Schuur hospital. (Thesis). University of Cape Town. Retrieved from http://hdl.handle.net/11427/25732

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Zent, Roy. “Rapidly progressive glomerulonephritis at Groote Schuur hospital.” 1992. Thesis, University of Cape Town. Accessed April 10, 2021. http://hdl.handle.net/11427/25732.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Zent, Roy. “Rapidly progressive glomerulonephritis at Groote Schuur hospital.” 1992. Web. 10 Apr 2021.

Vancouver:

Zent R. Rapidly progressive glomerulonephritis at Groote Schuur hospital. [Internet] [Thesis]. University of Cape Town; 1992. [cited 2021 Apr 10]. Available from: http://hdl.handle.net/11427/25732.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Zent R. Rapidly progressive glomerulonephritis at Groote Schuur hospital. [Thesis]. University of Cape Town; 1992. Available from: http://hdl.handle.net/11427/25732

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

19. Anaiara Lucena Queiroz. AvaliaÃÃo das glomerulopatias em pacientes acompanhados no serviÃo de nefrologia do Hospital Geral de Fortaleza.

Degree: 2012, Universidade Federal do CearÃ; Programa de PÃs-GraduaÃÃo em Patologia; UFC; BR

URL: http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=9301

►

nÃo hÃ

INTRODUÃÃO: as glomerulopatias ainda sÃo uma das principais causas de insuficiÃncia renal crÃnica no mundo. Ã crescente o surgimento de registros de glomerulopatias… (more)

▼

nÃo hÃ

INTRODUÃÃO: as glomerulopatias ainda sÃo uma das principais causas de insuficiÃncia renal crÃnica no mundo. Ã crescente o surgimento de registros de glomerulopatias em diversos paÃses, inclusive no Brasil. Os dados sobre incidÃncia e prevalÃncia das glomerulopatias no Brasil sÃo escassos. As conseqÃÃncias da lesÃo glomerular sÃo basicamente: proteinÃria, hematÃria, queda de filtraÃÃo glomerular, podendo evoluir para oligo-anÃria e hipertensÃo arterial decorrente da retenÃÃo de sÃdio. OBJETIVOS: determinar o perfil clÃnico, patolÃgico e epidemiolÃgico dos pacientes em acompanhamento no ambulatÃrio de glomerulopatias do ServiÃo de Nefrologia do Hospital Geral de Fortaleza. MÃTODOS: a populaÃÃo do estudo consistiu de pacientes portadores de doenÃa glomerular, submetidos Ã biÃpsia renal que foram atendidos no ambulatÃrio do serviÃo de Nefrologia do Hospital Geral de Fortaleza, CearÃ, durante o perÃodo de fevereiro de 2010 e setembro de 2011. RESULTADOS: foram incluÃdos no estudo um total de 168 pacientes. A idade mÃdia foi de 37 Â 14 anos, variando de 14-77 anos. Desse total 84 pacientes (50%) eram do sexo feminino. Na avaliaÃÃo dos resultados das amostras biopsiadas obteve-se uma mÃdia de 20 Â 12 glomÃrulos por amostra. Um total de 154 biÃpsias (92,2%) apresentaram um nÃmero maior ou igual a 8 glomÃrulos por amostra. SÃndrome nefrÃtica, foi a principal apresentaÃÃo clÃnica, correspondendo a um total de 113 pacientes (67,3%). As glomerulopatias mais prevalentes foram a GESF (19,6%), a LesÃo MÃnima (17,9%), a Glomerulopatia Membranosa (16,7%) e a Glomerulonefrite LÃpica (11,9%). As glomerulopatias primÃrias foram mais prevalentes, total de 124 casos (74,7%). Em relaÃÃo a resposta ao tratamento medicamentoso instituÃdo, 81 pacientes (68,6%) responderam ao tratamento.CONCLUSÃO: a GESF foi a glomerulopatia primÃria mais freqÃente e sÃndrome nefrÃtica a forma clÃnica de apresentaÃÃo mais comum na admissÃo. As amostras das biÃpsias renais colhidas foram satisfatÃrias em 92,2% dos casos.

INTRODUCTION: glomerulonephritis still are one of the main causes of Chronic Renal Failure (CRF). The number of cases is increasing, especially in Brazil. There are few data regarding the incidence and prevalence of glomerulonephritis in our country. Glomerular damage results in proteinuria, hematuria, decrease in glomerular filtration rate (GFR), oliguria, anuria and hypertension due to sodium overload. OBJECTIVES: the aim of this study is to determine the clinical, pathological and epidemiological features of the patients with glomerular diseases followed at the General Hospital of Fortaleza. METHODS: the study population consisted of patients with biopsy proven glomerular disease followed at the Nephrology Department of the General Hospital of Fortaleza, CearÃ, in the period between February 2010 and July 2011. RESULTS: a total of 168 patients were included. The mean age was 37 Â 14 years. The mean number of glomeruli in each renal biopsy was 20 Â 12. A total of 154 biopsies (92,2%) had at least 8 glomeruli per sample. Half of…

Advisors/Committee Members: Paulo Roberto Carvalho de Almeida, JosÃ Ajax Nogueira Queiroz, Luciano Pamplona de GÃes Cavalcanti, Claudia Maria Costa de Oliveira.

Subjects/Keywords: Epidemiology; Glomerulonephritis; Nephrotic Syndrome; Renal Biopsy; NEFROLOGIA

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Queiroz, A. L. (2012). AvaliaÃÃo das glomerulopatias em pacientes acompanhados no serviÃo de nefrologia do Hospital Geral de Fortaleza. (Masters Thesis). Universidade Federal do CearÃ; Programa de PÃs-GraduaÃÃo em Patologia; UFC; BR. Retrieved from http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=9301

Chicago Manual of Style (16^th Edition):

Queiroz, Anaiara Lucena. “AvaliaÃÃo das glomerulopatias em pacientes acompanhados no serviÃo de nefrologia do Hospital Geral de Fortaleza.” 2012. Masters Thesis, Universidade Federal do CearÃ; Programa de PÃs-GraduaÃÃo em Patologia; UFC; BR. Accessed April 10, 2021. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=9301.

MLA Handbook (7^th Edition):

Queiroz, Anaiara Lucena. “AvaliaÃÃo das glomerulopatias em pacientes acompanhados no serviÃo de nefrologia do Hospital Geral de Fortaleza.” 2012. Web. 10 Apr 2021.

Vancouver:

Queiroz AL. AvaliaÃÃo das glomerulopatias em pacientes acompanhados no serviÃo de nefrologia do Hospital Geral de Fortaleza. [Internet] [Masters thesis]. Universidade Federal do CearÃ; Programa de PÃs-GraduaÃÃo em Patologia; UFC; BR; 2012. [cited 2021 Apr 10]. Available from: http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=9301.

Council of Science Editors:

Queiroz AL. AvaliaÃÃo das glomerulopatias em pacientes acompanhados no serviÃo de nefrologia do Hospital Geral de Fortaleza. [Masters Thesis]. Universidade Federal do CearÃ; Programa de PÃs-GraduaÃÃo em Patologia; UFC; BR; 2012. Available from: http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=9301

University of Hong Kong

20. 梁志錦. The pathogenesis of IgA nephropathy: the roleof IgA molecule and the nature of IgA receptors.

Degree: 2003, University of Hong Kong

URL: http://hdl.handle.net/10722/30524

Subjects/Keywords: IgA glomerulonephritis.; Glomerulonephritis.; Kidney glomerulus - Diseases.

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

梁志錦.. (2003). The pathogenesis of IgA nephropathy: the roleof IgA molecule and the nature of IgA receptors. (Thesis). University of Hong Kong. Retrieved from http://hdl.handle.net/10722/30524

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

梁志錦.. “The pathogenesis of IgA nephropathy: the roleof IgA molecule and the nature of IgA receptors.” 2003. Thesis, University of Hong Kong. Accessed April 10, 2021. http://hdl.handle.net/10722/30524.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

梁志錦.. “The pathogenesis of IgA nephropathy: the roleof IgA molecule and the nature of IgA receptors.” 2003. Web. 10 Apr 2021.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete

Vancouver:

梁志錦.. The pathogenesis of IgA nephropathy: the roleof IgA molecule and the nature of IgA receptors. [Internet] [Thesis]. University of Hong Kong; 2003. [cited 2021 Apr 10]. Available from: http://hdl.handle.net/10722/30524.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

梁志錦.. The pathogenesis of IgA nephropathy: the roleof IgA molecule and the nature of IgA receptors. [Thesis]. University of Hong Kong; 2003. Available from: http://hdl.handle.net/10722/30524

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation

Brno University of Technology

21. Novotný, Michal. Návrh knihovny pro plánování trajektorie robotu: Design of path planning library for mobile robot.

Degree: 2019, Brno University of Technology

URL: http://hdl.handle.net/11012/17522

► This thesis deals with analyses of problems of path planning by means Rapidly-exploring Random Trees (RRT) algorithm. The teoretic part described of basic terms and… (more)

Subjects/Keywords: Plánování cesty; RRT (Rapidly-exploring Random Trees); Dynamická knihovna; Path planning; RRT (Rapidly-exploring Random Trees); Dynamic link library

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Novotný, M. (2019). Návrh knihovny pro plánování trajektorie robotu: Design of path planning library for mobile robot. (Thesis). Brno University of Technology. Retrieved from http://hdl.handle.net/11012/17522

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Novotný, Michal. “Návrh knihovny pro plánování trajektorie robotu: Design of path planning library for mobile robot.” 2019. Thesis, Brno University of Technology. Accessed April 10, 2021. http://hdl.handle.net/11012/17522.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Novotný, Michal. “Návrh knihovny pro plánování trajektorie robotu: Design of path planning library for mobile robot.” 2019. Web. 10 Apr 2021.

Vancouver:

Novotný M. Návrh knihovny pro plánování trajektorie robotu: Design of path planning library for mobile robot. [Internet] [Thesis]. Brno University of Technology; 2019. [cited 2021 Apr 10]. Available from: http://hdl.handle.net/11012/17522.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Novotný M. Návrh knihovny pro plánování trajektorie robotu: Design of path planning library for mobile robot. [Thesis]. Brno University of Technology; 2019. Available from: http://hdl.handle.net/11012/17522

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Brno University of Technology

22. Bartozel, Zdeněk. Plánování cesty v reálném čase: Real-time path planning.

Degree: 2019, Brno University of Technology

URL: http://hdl.handle.net/11012/179055

► The thesis deals with the path planning and movement of the holonomic robot in a dynamic environment. The aim of this work is implementation of… (more)

Subjects/Keywords: Realtime; plánování cesty; Rapidly-exploring random tree; RRT; holonomní plánování; Real-time; motion planing; Rapidly-exploring random tree; RRT; holonomic planing

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Bartozel, Z. (2019). Plánování cesty v reálném čase: Real-time path planning. (Thesis). Brno University of Technology. Retrieved from http://hdl.handle.net/11012/179055

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Bartozel, Zdeněk. “Plánování cesty v reálném čase: Real-time path planning.” 2019. Thesis, Brno University of Technology. Accessed April 10, 2021. http://hdl.handle.net/11012/179055.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Bartozel, Zdeněk. “Plánování cesty v reálném čase: Real-time path planning.” 2019. Web. 10 Apr 2021.

Vancouver:

Bartozel Z. Plánování cesty v reálném čase: Real-time path planning. [Internet] [Thesis]. Brno University of Technology; 2019. [cited 2021 Apr 10]. Available from: http://hdl.handle.net/11012/179055.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Bartozel Z. Plánování cesty v reálném čase: Real-time path planning. [Thesis]. Brno University of Technology; 2019. Available from: http://hdl.handle.net/11012/179055

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Zambia

23. Sonkwe, Brian. Early outcome of Ponseti Management of Idiopathic Clubfoot at the University Teaching Hospital Lusaka, Zambia .

Degree: 2012, University of Zambia

URL: http://hdl.handle.net/123456789/987

► Ponseti technique as a management method of Congenital Talipes equinovarus had not been evaluated as a treatment tool for the clubfoot in Zambia.The study set… (more)

Subjects/Keywords: Ponseti Management; Idiopathic Clubfoot

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Sonkwe, B. (2012). Early outcome of Ponseti Management of Idiopathic Clubfoot at the University Teaching Hospital Lusaka, Zambia . (Thesis). University of Zambia. Retrieved from http://hdl.handle.net/123456789/987

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Sonkwe, Brian. “Early outcome of Ponseti Management of Idiopathic Clubfoot at the University Teaching Hospital Lusaka, Zambia .” 2012. Thesis, University of Zambia. Accessed April 10, 2021. http://hdl.handle.net/123456789/987.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Sonkwe, Brian. “Early outcome of Ponseti Management of Idiopathic Clubfoot at the University Teaching Hospital Lusaka, Zambia .” 2012. Web. 10 Apr 2021.

Vancouver:

Sonkwe B. Early outcome of Ponseti Management of Idiopathic Clubfoot at the University Teaching Hospital Lusaka, Zambia . [Internet] [Thesis]. University of Zambia; 2012. [cited 2021 Apr 10]. Available from: http://hdl.handle.net/123456789/987.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Sonkwe B. Early outcome of Ponseti Management of Idiopathic Clubfoot at the University Teaching Hospital Lusaka, Zambia . [Thesis]. University of Zambia; 2012. Available from: http://hdl.handle.net/123456789/987

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

McMaster University

24. Upagupta, Chandak. Investigating the Extracellular Matrix in Pulmonary Fibrosis.

Degree: 2019, McMaster University

URL: http://hdl.handle.net/11375/24749

►

IPF is a progressive disease, characterized by dysregulated fibrosis of the extracellular matrix (ECM). The pathobiology of the disease is still unknown, and the median… (more)

▼

IPF is a progressive disease, characterized by dysregulated fibrosis of the extracellular matrix (ECM). The pathobiology of the disease is still unknown, and the median survival post-diagnosis is about 3-5 years. The two current US FDA approved drugs for IPF (nintedanib and pirfenidone) slow, but fail to reverse, disease progression. There is cumulating research that suggests the ECM is an active player in fibrosis. In this thesis, we summarized the current knowledge of ECM-cell interactions in the context of pulmonary fibrosis. To gain more mechanistic insight into the ECM characteristics that dictate cell behavior, we established a 3D ECM ex vivo system to assess the nonfibrotic and fibrotic ECM’s effect on fibroblasts. The ECM appears to promote both pathological and physiological cellular changes, depending on its structural and compositional properties. We also used this 3D ex vivo system as a preclinical tool to test the effect of directly inhibiting mechanotransduction in the fibrotic ECM – fibroblast profibrotic relationship. Lastly, since the fibrotic ECM seems to play a key role in progressive fibrosis, we evaluate if researchers are appropriately using the bleomycin model by starting interventions after ECM fibrosis is established. Over the past decade in the field, there has been an overall improvement in the appropriate therapeutic timing. In the preventative studies, however, there is still an inadequate characterization of inflammation. There is also poor transparency of preclinical-bleomycin data for clinically tested interventions for IPF. Addressing these shortcomings may improve the utility of the model at predicting an intervention’s success in clinical trials. These findings illustrate the ECM’s role in driving pulmonary fibrosis. Therefore, the ECM should be further investigated to understand disease progression, and reproduced in preclinical models to test interventions. This will improve the transition of pathobiological findings into efficient drug development for this devastating disease.

Thesis

Candidate in Philosophy

Idiopathic pulmonary fibrosis (IPF) (idiopathic - unknown cause; pulmonary - lungs; fibrosis - scarring) is characterized by progressive scarring of the lung extracellular matrix (ECM). The ECM is an organ’s backbone that provides structural and biochemical support to surrounding cells. Continued ECM scarring can lead to difficulty breathing, cough, and ultimately death. The cause of IPF is unknown, however, studies suggest that the scarred ECM can promote further scarring, and cause disease progression. In this thesis, we summarized the current knowledge of how the ECM interacts with cells. Using a 3D model we see that depending on the ECM’s structure and composition, it can promote both disease and healthy cellular changes. Lastly, we evaluate if researchers are appropriately using the bleomycin model (most common preclinical model for pulmonary fibrosis) by testing interventions after ECM fibrosis is established. We propose changes to improve its usefulness as a…

Advisors/Committee Members: Kolb, Martin, Medical Sciences.

Subjects/Keywords: Extracellular Matrix; Idiopathic pulmonary fibrosis

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Upagupta, C. (2019). Investigating the Extracellular Matrix in Pulmonary Fibrosis. (Thesis). McMaster University. Retrieved from http://hdl.handle.net/11375/24749

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Upagupta, Chandak. “Investigating the Extracellular Matrix in Pulmonary Fibrosis.” 2019. Thesis, McMaster University. Accessed April 10, 2021. http://hdl.handle.net/11375/24749.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Upagupta, Chandak. “Investigating the Extracellular Matrix in Pulmonary Fibrosis.” 2019. Web. 10 Apr 2021.

Vancouver:

Upagupta C. Investigating the Extracellular Matrix in Pulmonary Fibrosis. [Internet] [Thesis]. McMaster University; 2019. [cited 2021 Apr 10]. Available from: http://hdl.handle.net/11375/24749.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Upagupta C. Investigating the Extracellular Matrix in Pulmonary Fibrosis. [Thesis]. McMaster University; 2019. Available from: http://hdl.handle.net/11375/24749

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Boston University

25. Burley, Sarah Victoria. Review of current literature on the diagnosis and treatment of idiopathic pulmonary fibrosis.

Degree: MS, Medical Sciences, 2016, Boston University

URL: http://hdl.handle.net/2144/19208

► This thesis reviews the current literature on idiopathic pulmonary fibrosis (IPF), a progressive, scarring lung condition largely affecting older adults that is experiencing an increasing… (more)

▼ This thesis reviews the current literature on idiopathic pulmonary fibrosis (IPF), a progressive, scarring lung condition largely affecting older adults that is experiencing an increasing incidence in the U.S. and abroad. Two troubling clinical aspects of IPF are the difficulty of timely diagnosis and uncertain progression once diagnosed. The need for early detection is driven by the condition’s median survival rate post-diagnosis of about 3 years. Environmental and familial risk factors are important predictors of IPF, but cannot alone determine who is at risk for the condition. High-resolution computed tomography is currently the best non-invasive diagnostic tool, but many efforts are now underway to identify biological markers, which may aid not only in diagnosis, but illuminate both susceptibility and progression of the disease. Although the pathogenesis of IPF remains unclear, a compelling correlation has surfaced between the mechanics of IPF and herpes virus infection, which also may lead to a biological marker for the condition. Likewise, some genetic factors have shown promise in revealing pathogenesis and possible diagnosis. The only treatment currently available to ameliorate IPF is lung transplantation, but it is a last resort effort. In terms of pharmaceutical treatment, the most significant development has been the recent approval and use of two anti-fibrotic drugs, pirfenidone and nintedanib, that appear to slow the progression of the disease, but do not eliminate the fibrotic condition that impairs patients’ breathing. As efforts progress in addressing affirmative treatments for IPF, there is consensus that not enough is being done to address palliative and psychological needs of IPF. In sum, a review of the current literature suggests tremendous accomplishments have made in treating what remains a fatal condition, but much work remains to truly understand how and why IPF occurs, and whether, short of lung transplantation, there are treatments that can improve, not just maintain, patients’ health.

Subjects/Keywords: Medicine; Idiopathic pulmonary fibrosis

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Burley, S. V. (2016). Review of current literature on the diagnosis and treatment of idiopathic pulmonary fibrosis. (Masters Thesis). Boston University. Retrieved from http://hdl.handle.net/2144/19208

Chicago Manual of Style (16^th Edition):

Burley, Sarah Victoria. “Review of current literature on the diagnosis and treatment of idiopathic pulmonary fibrosis.” 2016. Masters Thesis, Boston University. Accessed April 10, 2021. http://hdl.handle.net/2144/19208.

MLA Handbook (7^th Edition):

Burley, Sarah Victoria. “Review of current literature on the diagnosis and treatment of idiopathic pulmonary fibrosis.” 2016. Web. 10 Apr 2021.

Vancouver:

Burley SV. Review of current literature on the diagnosis and treatment of idiopathic pulmonary fibrosis. [Internet] [Masters thesis]. Boston University; 2016. [cited 2021 Apr 10]. Available from: http://hdl.handle.net/2144/19208.

Council of Science Editors:

Burley SV. Review of current literature on the diagnosis and treatment of idiopathic pulmonary fibrosis. [Masters Thesis]. Boston University; 2016. Available from: http://hdl.handle.net/2144/19208

Delft University of Technology

26. Wermink, Suzanne (author). Improving Brace Effectiveness for Adolescent Idiopathic Scoliosis Patients.

Degree: 2019, Delft University of Technology

URL: http://resolver.tudelft.nl/uuid:7b3e70ed-d7b4-4035-a3bc-4855d96dc479

► Adolescent idiopathic scoliosis (AIS) is a three-dimensional deformity of the spine that can be treated by wearing a correctional rigid brace. The goal of brace… (more)

▼ Adolescent idiopathic scoliosis (AIS) is a three-dimensional deformity of the spine that can be treated by wearing a correctional rigid brace. The goal of brace treatment is prevention of curve progression, and in some cases the curve even decreases. The current problem concerning treatment of AIS lays in the design decisions made during manufacturing of the brace. Correctional forces are applied through static pressure pads added to the inside of the brace. Evaluation of the correct positioning and size of these forces is done through radiographic imaging which allows limited feedback intervals as cumulative exposure to ionizing radiation increases the risk of cancer development. The design of scoliotic braces is currently suboptimal as the manufacturing remains an inefficient process. Moreover, it was hypothesized that the corrective forces show decreasing time dependant behaviour due to viscoelastic properties of the human body adapting to the load. The objectives of this study were therefore to increase the effectiveness of brace treatment, by determination of the time dependant behaviour and accurate positioning and sizing of correctional forces. A dynamic brace was developed containing pressure regulated cuffs creating a three-point-bending system on the spine. A healthy (non-scoliotic) test subject wore the brace with the goal of creating a spinal curvature. The cuffs were tested on stress relaxation behaviour, which was needed to determine if possible changes in pressure were due to viscoelasticity of the cuffs or the body. The tests showed that pressure stayed constant over time, which excludes viscoelasticity of the cuffs. Moreover, compression tests were executed on a cuff to determine the relationship between external loads and internal pressures. Ultrasound (US) imaging was used to evaluate the effect of the three-point-bending system on the spine. The images showed a curvature, but the results varied too much to draw conclusions from, as this imaging technique works best for large scoliotic curves. BoneMRI has higher imaging accuracy and adds an extra dimension, however supine positioning decreases the spinal curvature. The boneMRI results show a subtle curvature after applying pressure. The cuffs lengthened the spine and caused mechanical torsion. After one hour the lengthening remained equal but the mechanical torsion decreased to its starting value. Lengthening of the spine could be useful in brace treatment to create more space between vertebrae and facilitate vertebral realignment. This research served as a proof of concept which can be further developed by testing on a scoliotic patient with a moderate spinal curvature. This could result in a dynamic brace used as a method to enhance the positioning and sizing of pressure pads for a static brace, or the dynamic brace design needs adjustment to use it as a daily worn brace which keeps correctional forces constant by adjusting pressures automatically. Advisors/Committee Members: Weinans, Harrie (mentor), Vallery, Heike (graduation committee), Tümer, Nazli (graduation committee), Delft University of Technology (degree granting institution), University Medical Center Utrecht (degree granting institution).

Subjects/Keywords: Brace; Adolescent Idiopathic Scoliosis; Manufacturing

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Wermink, S. (. (2019). Improving Brace Effectiveness for Adolescent Idiopathic Scoliosis Patients. (Masters Thesis). Delft University of Technology. Retrieved from http://resolver.tudelft.nl/uuid:7b3e70ed-d7b4-4035-a3bc-4855d96dc479

Chicago Manual of Style (16^th Edition):

Wermink, Suzanne (author). “Improving Brace Effectiveness for Adolescent Idiopathic Scoliosis Patients.” 2019. Masters Thesis, Delft University of Technology. Accessed April 10, 2021. http://resolver.tudelft.nl/uuid:7b3e70ed-d7b4-4035-a3bc-4855d96dc479.

MLA Handbook (7^th Edition):

Wermink, Suzanne (author). “Improving Brace Effectiveness for Adolescent Idiopathic Scoliosis Patients.” 2019. Web. 10 Apr 2021.

Vancouver:

Wermink S(. Improving Brace Effectiveness for Adolescent Idiopathic Scoliosis Patients. [Internet] [Masters thesis]. Delft University of Technology; 2019. [cited 2021 Apr 10]. Available from: http://resolver.tudelft.nl/uuid:7b3e70ed-d7b4-4035-a3bc-4855d96dc479.

Council of Science Editors:

Wermink S(. Improving Brace Effectiveness for Adolescent Idiopathic Scoliosis Patients. [Masters Thesis]. Delft University of Technology; 2019. Available from: http://resolver.tudelft.nl/uuid:7b3e70ed-d7b4-4035-a3bc-4855d96dc479

Universitat de Valencia

27. Ballester Llobell, Beatriz. Muc1 bioactivation contributes to lung fibrosis .

Degree: 2019, Universitat de Valencia

URL: http://hdl.handle.net/10550/70252

► INTRODUCCIÓN La fibrosis pulmonar idiopática (FPI) es una forma específica de neumonía intersticial fibrosante, progresiva, crónica y de causa desconocida. Recientemente se ha propuesto que… (more)

▼ INTRODUCCIÓN La fibrosis pulmonar idiopática (FPI) es una forma específica de neumonía intersticial fibrosante, progresiva, crónica y de causa desconocida. Recientemente se ha propuesto que la FPI surge a partir de episodios repetidos de daño en las células epiteliales alveolares, lo cual puede estar asociado con una liberación de mediadores profibróticos (como el factor de crecimiento transformante β1 (TGFβ1)), fomentando la activación descontrolada de fibroblastos, transformaciones celulares en células mesenquimales de tipo miofibroblasto y una acumulación excesiva de matriz extracelular en el intersticio pulmonar, lo cual destruye la arquitectura alveolar normal e interrumpe el intercambio de gases. El tiempo medio de supervivencia desde el diagnóstico de FPI es de 2 a 4 años y hasta la fecha, a pesar de la extensa investigación sobre la FPI, no se ha demostrado definitivamente que las terapias farmacológicas mejoren significativamente la esperanza de vida de la patología. La mucina 1 (MUC1) es una mucina transmembrana cuya sobreexpresión en carcinomas potencia la señalización intracelular mediante su fosforilación, bioactivación e interacción de su cola citoplasmática (MUC1-CT) con diversas proteínas implicadas en diferentes procesos celulares vinculados a la FPI. Además, el dominio extracelular de MUC1 contiene el epítopo KL6, que sirve como biomarcador en FPI. Sin embargo, no hay evidencia sobre el papel de la bioactivación intracelular de MUC1 en el desarrollo de la fibrosis pulmonar. Objetivos Caracterizar la bioactivación intracelular de MUC1 en la FPI. Metodos y resultados La expresión de MUC1-CT y sus formas fosforiladas en Thr41 y Tyr46 se analizaron mediante Western Blot e inmunohistoquímica en tejido pulmonar procedente de sujetos control o sujetos FPI. Los fibroblastos de pulmón y las células epiteliales alveolares de tipo II se estimularon con TGFβ1 o el factor pro-fibrótico galectina 3 para evaluar el papel de MUC1 en la transición epitelio-mesenquima y fibroblasto-mesenquima, la proliferación y la senescencia. Además, se usó un modelo de fibrosis pulmonar inducida por bleomicina en ratones MUC1-Knockout (KO) y ratones Wild type (WT). La expresión de MUC1-CT y sus formas fosforiladas en Thr41 y Tyr46 aumentaron en el tejido pulmonar de pacientes con FPI y ratones fibróticos inducidos por bleomicina. TGFβ1 incrementó las fosforilaciones Thr41 y Tyr46 de MUC1-CT, aumentando así la expresión del factor pro-fibrótico activo β-catenina para formar un complejo nuclear de fosfo-Smad3/MUC1-CT y MUC1-CT / β-catenina. El complejo nuclear activó las transiciones epitelio – mesénquima y fibroblasto – mesénquima, así como la senescencia celular y la proliferación de fibroblastos. La pirfenidona, así como la inhibición de la translocación nuclear de MUC1-CT, redujeron in vitro dichas transformaciones celulares así como los procesos de senescencia y proliferación. Por otro lado, la galectina 3 activó directamente MUC1-CT y sirvió como puente entre los receptores de TGFβ y el dominio MUC1-C, lo que indica… Advisors/Committee Members: Cortijo Gimeno, Julio (advisor).

Subjects/Keywords: idiopathic pulmonary fibrosis; mucin 1

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Ballester Llobell, B. (2019). Muc1 bioactivation contributes to lung fibrosis . (Doctoral Dissertation). Universitat de Valencia. Retrieved from http://hdl.handle.net/10550/70252

Chicago Manual of Style (16^th Edition):

Ballester Llobell, Beatriz. “Muc1 bioactivation contributes to lung fibrosis .” 2019. Doctoral Dissertation, Universitat de Valencia. Accessed April 10, 2021. http://hdl.handle.net/10550/70252.

MLA Handbook (7^th Edition):

Ballester Llobell, Beatriz. “Muc1 bioactivation contributes to lung fibrosis .” 2019. Web. 10 Apr 2021.

Vancouver:

Ballester Llobell B. Muc1 bioactivation contributes to lung fibrosis . [Internet] [Doctoral dissertation]. Universitat de Valencia; 2019. [cited 2021 Apr 10]. Available from: http://hdl.handle.net/10550/70252.

Council of Science Editors:

Ballester Llobell B. Muc1 bioactivation contributes to lung fibrosis . [Doctoral Dissertation]. Universitat de Valencia; 2019. Available from: http://hdl.handle.net/10550/70252

University of New South Wales

28. Marshall, Lee. Identifying transcriptional changes contributing to the increased risk and degeneration in idiopathic Parkinson's disease.

Degree: Clinical School - St Vincent's Hospital, 2017, University of New South Wales

URL: http://handle.unsw.edu.au/1959.4/60249 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:51032/SOURCE2?view=true

► Parkinson’s disease (PD) is a chronic disease characterized by the progressive degeneration of dopaminergic neurons and the deposition of lewy bodies, occurring in a stereotypical… (more)

▼ Parkinson’s disease (PD) is a chronic disease characterized by the progressive degeneration of dopaminergic neurons and the deposition of lewy bodies, occurring in a stereotypical pattern across the brain, known as Braak staging. Idiopathic PD is proposed to result from a complex interaction of multiple risk genes interacting with the environment in concert with the aging process. Supporting this hypothesis are the multiple large scale GWAS that have identified 1,000s of SNPs, referring to 100’s of loci, that increase an individual’s risk of developing idiopathic PD. This thesis has provided the first evidence of a dysregulated idiopathic PD lncRNA (PARNA) expressed from a highly significant PD GWAS locus, which results in the down-regulation of multiple protein-coding target genes, the impairment of the mitochondrial OXPHOS pathway and the upregulation of α-Syn. These results suggest that PARNA contributes to idiopathic PD through the sensitivity to mitochondrial OXPHOS dysfunction and increased neurotoxic α-Syn expression. This thesis also showed that elevated expression of PARNA protects against both mitochondrial OXPHOS inhibition and α-Syn induced toxicity, providing the first evidence that a lncRNA may provide a novel therapeutic avenue to treat idiopathic PD. This thesis also used the novel approach of performing RNA-Seq in several tissues reflecting different degenerative states within an individual, a post-pathologically affected, pre-overt pathologically affected and a pathologically unaffected brain region, within our idiopathic PD cohort, allowed for the identification of differentially expressed genes and molecular pathways specifically contributing to the increased risk of developing idiopathic PD, as well as the early and late stages of idiopathic PD degeneration. These result lead to the identification of idiopathic PD novel genes that may provide early/predictive biomarkers and novel idiopathic PD molecular pathways which may lead to new therapeutics to prevent/delay the disease. Advisors/Committee Members: Cooper, Antony, Clinical School - St Vincent's Hospital, Faculty of Medicine, UNSW.

Subjects/Keywords: Parkinson's disease; Idiopathic Parkinson's disease

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Marshall, L. (2017). Identifying transcriptional changes contributing to the increased risk and degeneration in idiopathic Parkinson's disease. (Doctoral Dissertation). University of New South Wales. Retrieved from http://handle.unsw.edu.au/1959.4/60249 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:51032/SOURCE2?view=true

Chicago Manual of Style (16^th Edition):

Marshall, Lee. “Identifying transcriptional changes contributing to the increased risk and degeneration in idiopathic Parkinson's disease.” 2017. Doctoral Dissertation, University of New South Wales. Accessed April 10, 2021. http://handle.unsw.edu.au/1959.4/60249 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:51032/SOURCE2?view=true.

MLA Handbook (7^th Edition):

Marshall, Lee. “Identifying transcriptional changes contributing to the increased risk and degeneration in idiopathic Parkinson's disease.” 2017. Web. 10 Apr 2021.

Vancouver:

Marshall L. Identifying transcriptional changes contributing to the increased risk and degeneration in idiopathic Parkinson's disease. [Internet] [Doctoral dissertation]. University of New South Wales; 2017. [cited 2021 Apr 10]. Available from: http://handle.unsw.edu.au/1959.4/60249 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:51032/SOURCE2?view=true.

Council of Science Editors:

Marshall L. Identifying transcriptional changes contributing to the increased risk and degeneration in idiopathic Parkinson's disease. [Doctoral Dissertation]. University of New South Wales; 2017. Available from: http://handle.unsw.edu.au/1959.4/60249 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:51032/SOURCE2?view=true

Texas A&M University

29. Herzogenrath, Jessica. Thinking American, Working American, Playing American Folk Dance in Chicago, 1890-1940.

Degree: PhD, History, 2014, Texas A&M University

URL: http://hdl.handle.net/1969.1/153525

► Examination of folk dance in the Chicago area from 1890 to 1940 reveals the centrality of the body to ideas about education in the early… (more)

▼ Examination of folk dance in the Chicago area from 1890 to 1940 reveals the centrality of the body to ideas about education in the early twentieth century. The dissertation illuminates the circulation of folk dance practices in higher education and settlement houses in Progressive Era Chicago in conjunction with the influences of gender, ethnicity, and race. Folk dance satisfied both white, native-born, middle-class American nostalgia for an imagined rural past and immigrant desire to retain ties to homelands. Women social workers and teachers promoted folk dance as a healthful exercise and an avenue of insight into other cultures while also presenting it as an embodiment of American values. Extension of the study into the interwar period (1920-1940) permits analysis of both the persistence of progressive ideologies concerning the body as practiced through folk dance and the central role of women in physical education. Over six chapters the dissertation address three primary points. First, it argues for the consideration of folk dance as an integral part of the physical education of children and young women as well as its function as an element of defining American-ness in both higher education and social settlements. Second, the dissertation demonstrates the prevalence of women as innovators in education, specifically through physical education curricula in colleges and universities. It also shows the connections between higher education and social settlements as two sites for learning that incorporated similar ideas about folk dance. Third, the dissertation assesses how Chicago, as a progressive center, facilitated the circulation of a set of folk dance practices grounded in Old World nostalgia and reframed it as part of the way to learn how to achieve a proper American body through similar curricula, instructors, and performances. Sources examined include records from colleges and universities such as course catalogs, programs, yearbooks, and campus newspapers; materials from social settlements, for example histories, programs, activity announcements, workers’ reports, and scrapbooks; personal papers of settlement workers and folk dance instructors; and folk dance manuals. Advisors/Committee Members: Blackwelder, Julia K (advisor), Livesay, Harold C (committee member), Blanton, Carlos K (committee member), Hamera, Judith (committee member).

Subjects/Keywords: Dance; Progressive Era

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Herzogenrath, J. (2014). Thinking American, Working American, Playing American Folk Dance in Chicago, 1890-1940. (Doctoral Dissertation). Texas A&M University. Retrieved from http://hdl.handle.net/1969.1/153525

Chicago Manual of Style (16^th Edition):

Herzogenrath, Jessica. “Thinking American, Working American, Playing American Folk Dance in Chicago, 1890-1940.” 2014. Doctoral Dissertation, Texas A&M University. Accessed April 10, 2021. http://hdl.handle.net/1969.1/153525.

MLA Handbook (7^th Edition):

Herzogenrath, Jessica. “Thinking American, Working American, Playing American Folk Dance in Chicago, 1890-1940.” 2014. Web. 10 Apr 2021.

Vancouver:

Herzogenrath J. Thinking American, Working American, Playing American Folk Dance in Chicago, 1890-1940. [Internet] [Doctoral dissertation]. Texas A&M University; 2014. [cited 2021 Apr 10]. Available from: http://hdl.handle.net/1969.1/153525.

Council of Science Editors:

Herzogenrath J. Thinking American, Working American, Playing American Folk Dance in Chicago, 1890-1940. [Doctoral Dissertation]. Texas A&M University; 2014. Available from: http://hdl.handle.net/1969.1/153525

University of the Western Cape

30. Kasu, Mohaimin. Validation and application of a highly discriminating and rapid 10-locus Y-STR DNA profiling system .

Degree: 2019, University of the Western Cape

URL: http://hdl.handle.net/11394/6760

► DNA profiling the male specific region on the Y-chromosome is fundamental to forensic practise. Its recognised as a powerful analytical tool for investigation of sexual… (more)

Subjects/Keywords: DNA profiling; Forensic genetics; Polymerase Chain Reaction; Rapidly mutating; Sexual assault

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Kasu, M. (2019). Validation and application of a highly discriminating and rapid 10-locus Y-STR DNA profiling system . (Thesis). University of the Western Cape. Retrieved from http://hdl.handle.net/11394/6760

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Kasu, Mohaimin. “Validation and application of a highly discriminating and rapid 10-locus Y-STR DNA profiling system .” 2019. Thesis, University of the Western Cape. Accessed April 10, 2021. http://hdl.handle.net/11394/6760.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Kasu, Mohaimin. “Validation and application of a highly discriminating and rapid 10-locus Y-STR DNA profiling system .” 2019. Web. 10 Apr 2021.

Vancouver:

Kasu M. Validation and application of a highly discriminating and rapid 10-locus Y-STR DNA profiling system . [Internet] [Thesis]. University of the Western Cape; 2019. [cited 2021 Apr 10]. Available from: http://hdl.handle.net/11394/6760.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Kasu M. Validation and application of a highly discriminating and rapid 10-locus Y-STR DNA profiling system . [Thesis]. University of the Western Cape; 2019. Available from: http://hdl.handle.net/11394/6760

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

		in
And / Or
		in
And / Or
		in
And / Or
		in

Open Access Theses and Dissertations