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1. Rigal, Mélanie. Etude de la stabilité de la méthylation ADN chez Arabidopsis thaliana et impact sur la transcription : Study of DNA methylation stability in Arabidopsis thaliana and impact on transcription.

Degree: Docteur es, Génétique et Physiologie Moléculaires, 2014, Université Blaise-Pascale, Clermont-Ferrand II

La maintenance de la méthylation ADN sur les sites CG joue un rôle crucial dans le silencing des éléments transposables (TE) et l’expression correcte des gènes. Chez Arabidopsis thaliana, on observe, dans le mutant met1-3 déficient en méthylation CG, une apparition ectopique de méthylation CHG sur de nombreux gènes, ainsi qu’une relocalisation de la diméthylation de la lysine 9 de l’histone H3 (H3K9me2) de l’hétérochromatine vers l’euchromatine. Nous avons démontré que ceci est lié à un défaut de transcription au niveau du grand intron du gène codant la déméthylase H3K9me2 IBM1. Nous avons également constaté que dans les épihybrides F1 issus du croisement de plantes met1-3 avec une plante sauvage la méthylation CHG présente dans l’intron de l’allèle IBM1 hérité du parent mutant était perdue. Afin de définir si la perte de méthylation affecte également d’autres loci génomiques, et plus globalement à l’échelle du génome entier l’impact de la rencontre de deux épigénomes différents, nous avons analysé les profils de méthylation, de siRNAs et de transcription des épihybrides F1. Nos données révèlent que l’union de deux méthylomes distincts au sein d’un même génome provoque une restructuration considérable des profils épigénétiques et transcriptionnels. La méthylation CHG apparaissant sur de nombreux gènes dans met1 tend à persister, créant ainsi de nouveaux épiallèles pouvant être hérités. Du côté des TE, nombre d’entre eux sont déméthylés et réactivés, tandis que d’autres sont immédiatement reméthylés et resilencés. Ainsi, ces résultats contribuent à la compréhension de la stabilité de la méthylation ADN et de son rôle dans le contrôle différentiel des gènes et des TE.

Maintenance of DNA methylation at CG sites is crucial for silencing of transposable element (TE) and proper expression of genes. In Arabidopsis thaliana, met1-3 mutant, deficient in CG methylation, shows ectopic appearance of CHG methylation at numerous genes, as well as relocation of H3K9me2, from heterochromatin towards euchromatin. We have shown that this is due to a defect of the transcription of the large intron of the gene encoding the IBM1 H3K9me2 demethylase. We also found that, in the F1 epihybrids from the cross between met1 and WT plants, CHG methylation at the intron of the met1-derived IBM1 allele is lost. In order to define whether the loss of methylation at IBM1 also affects other genomic loci, and the impact of the union of two different epigenomes on methylation and transcription genome-wide, we analyzed the methylation, siRNA and transcription patterns of F1 epihybrids. Our data reveal that the union of two distinct methylomes within the same genome triggers considerable restructuring of epigenetic and transcriptional patterns. CHG methylation appearing in the mutant parent tends to persist in F1, creating new epialleles that can be inherited. On the TE side, lots of them are demethylated and reactivated while others are immediately remethylated and resilenced. Thus, our results provide new insights to the understanding of DNA…

Advisors/Committee Members: Mathieu, Olivier (thesis director).

Subjects/Keywords: Arabidopsis; Épigénétique; Méthylation ADN; MET1; Hybrides; IBM1; Histone; H3K9me2; Transcription; SiRNA; Arabidopsis; Epigenetic; DNA methylation; MET1; Hybrids; IBM1; Histone; H3K9me2; Transcription; SiRNA

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Rigal, M. (2014). Etude de la stabilité de la méthylation ADN chez Arabidopsis thaliana et impact sur la transcription : Study of DNA methylation stability in Arabidopsis thaliana and impact on transcription. (Doctoral Dissertation). Université Blaise-Pascale, Clermont-Ferrand II. Retrieved from http://www.theses.fr/2014CLF22496

Chicago Manual of Style (16th Edition):

Rigal, Mélanie. “Etude de la stabilité de la méthylation ADN chez Arabidopsis thaliana et impact sur la transcription : Study of DNA methylation stability in Arabidopsis thaliana and impact on transcription.” 2014. Doctoral Dissertation, Université Blaise-Pascale, Clermont-Ferrand II. Accessed April 11, 2021. http://www.theses.fr/2014CLF22496.

MLA Handbook (7th Edition):

Rigal, Mélanie. “Etude de la stabilité de la méthylation ADN chez Arabidopsis thaliana et impact sur la transcription : Study of DNA methylation stability in Arabidopsis thaliana and impact on transcription.” 2014. Web. 11 Apr 2021.

Vancouver:

Rigal M. Etude de la stabilité de la méthylation ADN chez Arabidopsis thaliana et impact sur la transcription : Study of DNA methylation stability in Arabidopsis thaliana and impact on transcription. [Internet] [Doctoral dissertation]. Université Blaise-Pascale, Clermont-Ferrand II; 2014. [cited 2021 Apr 11]. Available from: http://www.theses.fr/2014CLF22496.

Council of Science Editors:

Rigal M. Etude de la stabilité de la méthylation ADN chez Arabidopsis thaliana et impact sur la transcription : Study of DNA methylation stability in Arabidopsis thaliana and impact on transcription. [Doctoral Dissertation]. Université Blaise-Pascale, Clermont-Ferrand II; 2014. Available from: http://www.theses.fr/2014CLF22496


University of Guelph

2. Jigmeddorj, Badamsambuu. Nuclear Structure of \(^{122}Xe\) Studied via High-Statistics \(\beta^+/EC\) Decay of \(^{122}Cs\).

Degree: PhD, Department of Physics, 2019, University of Guelph

The Xe isotopes are located at a possible phase change in the collective structure from vibrational to rotational. The Xe isotopes therefore were considered as potential candidates for (γ)-soft nuclei or (O(6)) symmetry limit within the IBM. However, testing of the O(6) symmetry in Xe reveals that indeed their structure is more complicated. The study of the nucleus (122Xe) is a part of a systematic examination of the development of collectivity in the Xe isotopes, which are located in the (Z>50), (N<82) region that display an extraordinarily smooth evolution of simple collective signatures. In order to probe the development of collectivity in greater detail, additional information on excited states is required. Specifically, the knowledge of excited states that decay to other excited states resulting low-energy transitions which can give strong indicators of the underlying structure need to be improved . The experiment to study (122Xe) with the (β+/EC) decay of (122Cs) was performed at the TRIUMF-ISAC facility located in Vancouver, B.C., Canada. Radioactive (122Cs) beams from the ISAC facility were delivered to the 8(π) spectrometer which was composed of 20 HPGe detectors. The isomeric and ground states of (122Cs) decay to the (122Xe) with half lives of 21 seconds and a 3.7 minutes, respectively. Two sets of high-statistics data for short- and long-half-life decays were collected to have an access for potential excited states of the (122Xe). As an evidence of data quality, the level scheme of (122Xe) has been dramatically extended by 177 new levels and 482 new transitions. Using (γ)-(γ) angular correlation analysis, 71 spin assignments have been made for 55 levels since a spin of some levels could be assigned via several different cascades. Mixing ratios for 44 (γ)-ray transitions were extracted from the angular correlation analysis by extracting the values from the minimized (χ2) fit. Branching ratios have been determined for all observed transitions independently in the two different data sets collected with the short and long cycled runs. The data have been compared with a sd-IBM-1 calculation. Advisors/Committee Members: Garrett, Paul (advisor).

Subjects/Keywords: Xe-122; beta decay; nuclear structure; Angular Correlation Analysis; level scheme; branching ratios; IBM1; Relative B(E2); Spin assignment

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Jigmeddorj, B. (2019). Nuclear Structure of \(^{122}Xe\) Studied via High-Statistics \(\beta^+/EC\) Decay of \(^{122}Cs\). (Doctoral Dissertation). University of Guelph. Retrieved from https://atrium.lib.uoguelph.ca/xmlui/handle/10214/15852

Chicago Manual of Style (16th Edition):

Jigmeddorj, Badamsambuu. “Nuclear Structure of \(^{122}Xe\) Studied via High-Statistics \(\beta^+/EC\) Decay of \(^{122}Cs\).” 2019. Doctoral Dissertation, University of Guelph. Accessed April 11, 2021. https://atrium.lib.uoguelph.ca/xmlui/handle/10214/15852.

MLA Handbook (7th Edition):

Jigmeddorj, Badamsambuu. “Nuclear Structure of \(^{122}Xe\) Studied via High-Statistics \(\beta^+/EC\) Decay of \(^{122}Cs\).” 2019. Web. 11 Apr 2021.

Vancouver:

Jigmeddorj B. Nuclear Structure of \(^{122}Xe\) Studied via High-Statistics \(\beta^+/EC\) Decay of \(^{122}Cs\). [Internet] [Doctoral dissertation]. University of Guelph; 2019. [cited 2021 Apr 11]. Available from: https://atrium.lib.uoguelph.ca/xmlui/handle/10214/15852.

Council of Science Editors:

Jigmeddorj B. Nuclear Structure of \(^{122}Xe\) Studied via High-Statistics \(\beta^+/EC\) Decay of \(^{122}Cs\). [Doctoral Dissertation]. University of Guelph; 2019. Available from: https://atrium.lib.uoguelph.ca/xmlui/handle/10214/15852

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