subject:(Hypothalamus pituitary)

University of Adelaide

1. Szarek, Eva. Genetic control of hypothalamo-pituitary axis development and function in mice.

Degree: 2011, University of Adelaide

► Congenital dysfunction of the hypothalamic-pituitary (HP) axis occurs in approximately one birth per 2,200 and is associated with a broad range of common disease states… (more)

▼ Congenital dysfunction of the hypothalamic-pituitary (HP) axis occurs in approximately one birth per 2,200 and is associated with a broad range of common disease states including impaired growth (short stature), infertility, hypogonadism poor responses to stress and slow metabolism (Pescovitz and Eugster, 2004). Although, a number of genes have been linked to diseases of the HP axis, the genetic cause in many patients remains unknown. This thesis examines two aspects of HP axis development and function. The first aim was to identify Sox3 targets by examining gene expression differences between three mouse lines: Sox3-null (mice lacking Sox3; loss of function), Extra-Sox3 (mice overexpressing Sox3; gain of function) and wild-type, by genome wide profiling using the Illumina BeadChip microarray platform. The second aim was to characterize the downstream effects relative to HP development in a novel recessive dwarf mouse model with pituitary hypoplasia and growth hormone (GH) deficiency, generated by N-ethyl-Nnitrosourea (ENU) mutagenesis that produces a point mutation in the gene for the enzyme tryptophanyl-tRNA synthetase (WARS). The first project (project 1) examined Sox3, the causative gene associated with Xlinked hypopituitarism (XH), in wild-type and transgenic mice. SOX3 is a member of the SOX (SRY-related HMG box) gene family of transcription factors that is expressed in progenitor cells of the mouse embryonic central nervous system (CNS) including the developing and postnatal hypothalamus (Rizzoti et al., 2004). It is the only member of the SOXB1 subfamily positioned on the X chromosome (Collignon et al., 1996; Stevanovic, 2003). Appropriate dose- and time-dependent expression of Sox3 in the developing hypothalamus is required for normal neuroendocrine function, particularly related to growth and growth hormone (GH). Changes associated with a loss-of-function and/or gain-of-function of Sox3 may contribute to a better understanding of other important genes, currently not known, involved in XH and/or X-linked mental retardation. At this point, however, the mechanisms linking SOX3 to its direct targets and their interplay within other downstream signaling cascades regulating HP axis development remain unknown. In order to identify Sox3-dependent genes, in mice, I performed microarray analysis of RNA extracted from embryonic mouse heads at 10.5 days post coitum (dpc) and compared RNA from wild-type, loss-of-function (Sox3-null) and gain-of-function (Extra-Sox3) mice. Several emergent candidate genes were further tested by quantitative mRNA expression analysis (qPCR). One of these was Neurogenin-3 (Ngn3), which showed a 2.5- fold decrease (P<0.001) in expression by microarray in Sox3-null (n=6), compared with wild-type (WT; n=6) mice and 1.8-fold decrease (P<0.001) by qPCR between Sox3-null (n=6) and WT (n=6) mice. To evaluate the relationship between Ngn3 and Sox3 at a cellular level immunohistochemistry was performed on 10.5 dpc and 12.5 dpc brains. In WT mice at 10.5 dpc and 12.5 dpc Ngn3 and Sox3 expression… Advisors/Committee Members: Thomas, Paul Quinton (advisor), Schwartz, Jeffrey (advisor), School of Molecular and Biomedical Science (school).

Subjects/Keywords: hypothalamus; pituitary; mice

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APA (6^th Edition):

Szarek, E. (2011). Genetic control of hypothalamo-pituitary axis development and function in mice. (Thesis). University of Adelaide. Retrieved from http://hdl.handle.net/2440/69221

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Szarek, Eva. “Genetic control of hypothalamo-pituitary axis development and function in mice.” 2011. Thesis, University of Adelaide. Accessed January 18, 2021. http://hdl.handle.net/2440/69221.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Szarek, Eva. “Genetic control of hypothalamo-pituitary axis development and function in mice.” 2011. Web. 18 Jan 2021.

Vancouver:

Szarek E. Genetic control of hypothalamo-pituitary axis development and function in mice. [Internet] [Thesis]. University of Adelaide; 2011. [cited 2021 Jan 18]. Available from: http://hdl.handle.net/2440/69221.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Szarek E. Genetic control of hypothalamo-pituitary axis development and function in mice. [Thesis]. University of Adelaide; 2011. Available from: http://hdl.handle.net/2440/69221

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

North Carolina State University

2. Couse, John Floyd. The Role of Estrogen Receptor-a and Estrogen Receptor-b in the Hyperluteinized Mouse Ovary.

Degree: PhD, Toxicology, 2004, North Carolina State University

URL: http://www.lib.ncsu.edu/resolver/1840.16/5400

► The hypothalamic-pituitary-gonadal (HPG) axis was characterized in female mice lacking one or both forms of estrogen receptor (ERa, ERb) with the aim of elucidating the… (more)

▼ The hypothalamic-pituitary-gonadal (HPG) axis was characterized in female mice lacking one or both forms of estrogen receptor (ERa, ERb) with the aim of elucidating the contribution of each receptor form to gonadotropin homeostasis and ovarian function. These studies consisted of a thorough evaluation of gene expression for the gonadotropin subunits in the pituitary and the components necessary for steroidogenesis in the ovary. These data were corroborated with evaluations of the plasma levels for each of the relevant pituitary and gonadal hormones. Females lacking ERb (bERKO) exhibit minimal disruption in HPG axis function but do exhibit deficits in gonadotropin responsiveness in the ovary. Females lacking ERa (aERKO) exhibit dramatic ovarian phenotypes of hemorrhagic and cystic follicles and exaggerated steroid synthesis in the ovaries. The phenotypes in the aERKO ovary are attributable to chronically elevated LH due to the loss of ERa function in the hypothalamus. Pharmacologic reduction of plasma LH levels in aERKO females abates the ovarian phenotypes. These studies indicate that the hypothalamic functions of ERa are most critical to ovarian function. To better understand the contribution of ERb to the manifestations of LH-hyperstimulation in the ovary, females lacking functional ERb but possessing elevated LH via a transgene (bERKOLHCTP) were generated. Characterization of bERKOLHCTP animals indicates the intraovarian functions of ERb are necessary for the induction of LH-associated cystic follicles but not amplified steroidogenesis. An additional novel finding in aERKO ovaries was ectopic expression of the Leydig cell specific enzyme, 17b-HSD III and correlating male-like testosterone synthesis. This phenotype is dependent on LH-hyperstimulation of ovaries lacking ERa function to manifest. In summary, the predominant contribution of ERa to ovarian function occurs in the hypothalamus, whereas ERb is more important within the ovary itself. Presence of Leydig cell specific gene expression in aERKO ovaries indicates a potential role for estradiol and ERa in gonadal differentiation. Advisors/Committee Members: Robert C. Smart, Committee Chair (advisor), Kenneth S. Korach, Committee Co-Chair (advisor), Gerald A. LeBlanc, Committee Member (advisor), William L. Miller, Committee Member (advisor).

Subjects/Keywords: pituitary; hypothalamus; steroidogenesis

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APA (6^th Edition):

Couse, J. F. (2004). The Role of Estrogen Receptor-a and Estrogen Receptor-b in the Hyperluteinized Mouse Ovary. (Doctoral Dissertation). North Carolina State University. Retrieved from http://www.lib.ncsu.edu/resolver/1840.16/5400

Chicago Manual of Style (16^th Edition):

Couse, John Floyd. “The Role of Estrogen Receptor-a and Estrogen Receptor-b in the Hyperluteinized Mouse Ovary.” 2004. Doctoral Dissertation, North Carolina State University. Accessed January 18, 2021. http://www.lib.ncsu.edu/resolver/1840.16/5400.

MLA Handbook (7^th Edition):

Couse, John Floyd. “The Role of Estrogen Receptor-a and Estrogen Receptor-b in the Hyperluteinized Mouse Ovary.” 2004. Web. 18 Jan 2021.

Vancouver:

Couse JF. The Role of Estrogen Receptor-a and Estrogen Receptor-b in the Hyperluteinized Mouse Ovary. [Internet] [Doctoral dissertation]. North Carolina State University; 2004. [cited 2021 Jan 18]. Available from: http://www.lib.ncsu.edu/resolver/1840.16/5400.

Council of Science Editors:

Couse JF. The Role of Estrogen Receptor-a and Estrogen Receptor-b in the Hyperluteinized Mouse Ovary. [Doctoral Dissertation]. North Carolina State University; 2004. Available from: http://www.lib.ncsu.edu/resolver/1840.16/5400

3. Gorbenko del Blanco, Darya. Exploring the Spectrum of Pituitary Hormone Deficiencies: Genotype, molecular mechanisms and phenotypic variability.

Degree: 2011, Erasmus University Medical Center

URL: http://hdl.handle.net/1765/30656

textabstractImportant functions in our body, such as development, growth, reproduction, metabolism, temperature or response to stress are regulated by molecules called hormones. The hypothalamus and the pituitary gland are the main regulators of all hormone signaling pathways and endocrine glands of the body, like the thyroid, adrenals and gonads.

Subjects/Keywords: hypothalamus; pituitary

…development [10]; Shh null mice lack a hypothalamus as well as a pituitary [11]… …absent adrenal responses to stimulation of pituitary or hypothalamus with intact or reduced… …is directly required for the differentiation of the pituitary gland during embryonic… …midface, characterized by pituitary agenesis [12-21]. A B Figure 3. Pituitary… …development. (A) Drawings of rodent pituitary development: 1, growth of pre-infundibular…

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APA (6^th Edition):

Gorbenko del Blanco, D. (2011). Exploring the Spectrum of Pituitary Hormone Deficiencies: Genotype, molecular mechanisms and phenotypic variability. (Doctoral Dissertation). Erasmus University Medical Center. Retrieved from http://hdl.handle.net/1765/30656

Chicago Manual of Style (16^th Edition):

Gorbenko del Blanco, Darya. “Exploring the Spectrum of Pituitary Hormone Deficiencies: Genotype, molecular mechanisms and phenotypic variability.” 2011. Doctoral Dissertation, Erasmus University Medical Center. Accessed January 18, 2021. http://hdl.handle.net/1765/30656.

MLA Handbook (7^th Edition):

Gorbenko del Blanco, Darya. “Exploring the Spectrum of Pituitary Hormone Deficiencies: Genotype, molecular mechanisms and phenotypic variability.” 2011. Web. 18 Jan 2021.

Vancouver:

Gorbenko del Blanco D. Exploring the Spectrum of Pituitary Hormone Deficiencies: Genotype, molecular mechanisms and phenotypic variability. [Internet] [Doctoral dissertation]. Erasmus University Medical Center; 2011. [cited 2021 Jan 18]. Available from: http://hdl.handle.net/1765/30656.

Council of Science Editors:

Gorbenko del Blanco D. Exploring the Spectrum of Pituitary Hormone Deficiencies: Genotype, molecular mechanisms and phenotypic variability. [Doctoral Dissertation]. Erasmus University Medical Center; 2011. Available from: http://hdl.handle.net/1765/30656

University of Newcastle

4. Fenner, Neal O. Does the Hypothalamus-Pituitary-Adrenal axis play a role in the immune response to gastrointestinal nematodes?.

Degree: PhD, 2013, University of Newcastle

URL: http://hdl.handle.net/1959.13/1037433

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Research Doctorate - Doctor of Philosophy (PhD)

The aim of this study was to establish a model for examining the role of the neuroendocrine system… (more)

Subjects/Keywords: Hypothalamus-Pituitary-Adrenal axis; gastrointestinal; nematodes; neuroendocrine system

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APA (6^th Edition):

Fenner, N. O. (2013). Does the Hypothalamus-Pituitary-Adrenal axis play a role in the immune response to gastrointestinal nematodes?. (Doctoral Dissertation). University of Newcastle. Retrieved from http://hdl.handle.net/1959.13/1037433

Chicago Manual of Style (16^th Edition):

Fenner, Neal O. “Does the Hypothalamus-Pituitary-Adrenal axis play a role in the immune response to gastrointestinal nematodes?.” 2013. Doctoral Dissertation, University of Newcastle. Accessed January 18, 2021. http://hdl.handle.net/1959.13/1037433.

MLA Handbook (7^th Edition):

Fenner, Neal O. “Does the Hypothalamus-Pituitary-Adrenal axis play a role in the immune response to gastrointestinal nematodes?.” 2013. Web. 18 Jan 2021.

Vancouver:

Fenner NO. Does the Hypothalamus-Pituitary-Adrenal axis play a role in the immune response to gastrointestinal nematodes?. [Internet] [Doctoral dissertation]. University of Newcastle; 2013. [cited 2021 Jan 18]. Available from: http://hdl.handle.net/1959.13/1037433.

Council of Science Editors:

Fenner NO. Does the Hypothalamus-Pituitary-Adrenal axis play a role in the immune response to gastrointestinal nematodes?. [Doctoral Dissertation]. University of Newcastle; 2013. Available from: http://hdl.handle.net/1959.13/1037433

5. Russart, Kathryn Lee Gruchalla. Hypothalamus And Pituitary Gland Development In The Common Snapping Turtle, Chelydra Serpentina, And Disruption With Atrazine Exposure.

Degree: PhD, Biology, 2016, University of North Dakota

URL: https://commons.und.edu/theses/2069

► Neural control of the endocrine system originates in the hypothalamus in all vertebrates. The hypothalamus signals directly to the pituitary gland to maintain homeostasis… (more)

▼ Neural control of the endocrine system originates in the hypothalamus in all vertebrates. The hypothalamus signals directly to the pituitary gland to maintain homeostasis by releasing hormones directly into the bloodstream. Hormones travel to peripheral endocrine organs, and regulate widespread activities including growth, metabolism, stress response, circadian rhythms, water balance, and reproduction. Many of these functions have sex-specific aspects, and therefore sexual dimorphism in morphology and function of the hypothalamus is present. Sex-specific genetic background and morphology is established during pre- and peri-natal development, during which sexually dimorphic cellular differentiation occurs and hormonal profiles are set. Disruption of development can therefore have widespread sex-specific effects. A thorough understanding of underlying molecular regulation of sex-specific development is therefore important for understanding disease and dysfunction. Here, we present four studies investigating the sex-specific development of the hypothalamus and pituitary gland in the common snapping turtle, a species with temperature-dependent sex determination. First, we tracked morphological development of the pituitary gland from its origin early in embryogenesis through hatching. Development is a highly conserved process between vertebrate species. Next, we analyzed sex differences in gene expression within the hypothalamus and pituitary gland in embryonic and hatchling turtles. We specifically analyze expression of genes involved in reproductive neuroendocrine function, and also use RNA-seq to identify all differentially expressed genes between sexes and development to further understanding of the underlying mechanisms of development and function. We identified overrepresented functional categories of the differentially expressed gene sets between sexes, and identify protein modification as a potential mechanism underlying sexual dimorphism. Last, we analyzed changes in neuroendocrine gene expression following embryonic exposure to the widely used herbicide atrazine, an endocrine disrupting chemical. Our results indicate an acute, embryonic exposure to atrazine can have persistent changes in expression of genes involved in stress response and reproduction in both the hypothalamus and pituitary gland. This dissertation adds to the body of literature on comparative neuroendocrine development, provides background information for numerous future experiments, and identifies the snapping turtle as another species with potential impacts from atrazine exposure. Advisors/Committee Members: Turk Rhen.

Subjects/Keywords: Atrazine; Endocrine Disruption; Gene Expression; Hypothalamus; Neuroendocrine Development; Pituitary Gland

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APA (6^th Edition):

Russart, K. L. G. (2016). Hypothalamus And Pituitary Gland Development In The Common Snapping Turtle, Chelydra Serpentina, And Disruption With Atrazine Exposure. (Doctoral Dissertation). University of North Dakota. Retrieved from https://commons.und.edu/theses/2069

Chicago Manual of Style (16^th Edition):

Russart, Kathryn Lee Gruchalla. “Hypothalamus And Pituitary Gland Development In The Common Snapping Turtle, Chelydra Serpentina, And Disruption With Atrazine Exposure.” 2016. Doctoral Dissertation, University of North Dakota. Accessed January 18, 2021. https://commons.und.edu/theses/2069.

MLA Handbook (7^th Edition):

Russart, Kathryn Lee Gruchalla. “Hypothalamus And Pituitary Gland Development In The Common Snapping Turtle, Chelydra Serpentina, And Disruption With Atrazine Exposure.” 2016. Web. 18 Jan 2021.

Vancouver:

Russart KLG. Hypothalamus And Pituitary Gland Development In The Common Snapping Turtle, Chelydra Serpentina, And Disruption With Atrazine Exposure. [Internet] [Doctoral dissertation]. University of North Dakota; 2016. [cited 2021 Jan 18]. Available from: https://commons.und.edu/theses/2069.

Council of Science Editors:

Russart KLG. Hypothalamus And Pituitary Gland Development In The Common Snapping Turtle, Chelydra Serpentina, And Disruption With Atrazine Exposure. [Doctoral Dissertation]. University of North Dakota; 2016. Available from: https://commons.und.edu/theses/2069

University of Georgia

6. Hamilton, Matthew Thomas. Characterizing stress and immune parameters in the American alligator (Alligator mississippiensis).

Degree: 2016, University of Georgia

URL: http://hdl.handle.net/10724/36127

► Crocodilians are exposed to a suite of abiotic and biotic stressors that have the potential to influence individual and population health. I collected pre- and… (more)

Subjects/Keywords: American alligator; Alligator mississippiensis; Stressors; Hypothalamus-Pituitary-Adrenal Axis (HPA); Glucocorticoids

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APA (6^th Edition):

Hamilton, M. T. (2016). Characterizing stress and immune parameters in the American alligator (Alligator mississippiensis). (Thesis). University of Georgia. Retrieved from http://hdl.handle.net/10724/36127

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Hamilton, Matthew Thomas. “Characterizing stress and immune parameters in the American alligator (Alligator mississippiensis).” 2016. Thesis, University of Georgia. Accessed January 18, 2021. http://hdl.handle.net/10724/36127.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Hamilton, Matthew Thomas. “Characterizing stress and immune parameters in the American alligator (Alligator mississippiensis).” 2016. Web. 18 Jan 2021.

Vancouver:

Hamilton MT. Characterizing stress and immune parameters in the American alligator (Alligator mississippiensis). [Internet] [Thesis]. University of Georgia; 2016. [cited 2021 Jan 18]. Available from: http://hdl.handle.net/10724/36127.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Hamilton MT. Characterizing stress and immune parameters in the American alligator (Alligator mississippiensis). [Thesis]. University of Georgia; 2016. Available from: http://hdl.handle.net/10724/36127

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

7. Jolitz, Eric Steven. Evaluation of the Hypothalamic Kisspeptin System Throughout the Estrous Cycle and During the Attainment of Puberty in Gilts.

Degree: MS, Animal Science, 2016, South Dakota State University

URL: https://openprairie.sdstate.edu/etd/1004

► Kisspeptin has been demonstrated to affect reproductive cyclicity and the attainment of puberty in multiple species, presumably through its actions on GnRH and LH,… (more)

▼ Kisspeptin has been demonstrated to affect reproductive cyclicity and the attainment of puberty in multiple species, presumably through its actions on GnRH and LH, as demonstrated in other species. Kisspeptin administration causes increased plasma concentrations of LH in pigs, sheep, and rats. Two experiments were conducted to evaluate 1) the hypothalamic kisspeptin system throughout various days of the estrous cycle and 2) the hypothalamic kisspeptin system during the peripubertal period in gilts. In experiment 1, 40 crossbred gilts (191 d, 121 kg) were administered an intramuscular injection of PG600. Twelve days after the administration of PG600, gilts were fed 15 mg of altrenogest daily for 15 d to synchronize estrus. Following estrus synchronization, estrus detection was performed by exposing gilts to a mature boar and the first day gilts stood immobile was denoted d 1 of the estrous cycle. Blood samples were collected via jugular venipuncture on d 1, 4, 7, 9, 14, 16, and 19 of the estrous cycle. Ten animals were slaughtered on d 1, 9, 14, and 21 of the estrous cycle when MBH, AP, and blood were collected. Relative expression of hypothalamic Kiss1, Kiss1R, ER-alpha, ER-beta and beta-actin was determined using real-time reverse transcriptase PCR. Fold changes in relative expression were determined using the Relative Expression Software Tool. Relative expression of Kiss1 was increased (P=0.006) 3.2 fold on d 1 versus d 21 and (P=0.003) 2.3 fold on d 9 versus d 21 of the estrous cycle. Relative expression of Kiss1 was not different (P>0.05) among the remaining days. Relative expression of ER-beta was decreased (P=0.05) 0.8 fold on d 9 versus d 21 and (P=0.005) 0.7 fold on d 14 versus d 21. Relative expression of ER-beta was not different (P>0.05) among the remaining days. Relative expression of Kiss1R and ER-alpha were each not different (P>0.05) among days. In experiment 2, two studies were performed, each with 25 crossbred gilts (151 d, 105 kg). In study 1 gilts were slaughtered on d 7 and in study 2 gilts were slaughtered on d 8. Gilts were relocated and exposed to a mature boar throughout study to naturally induce puberty. Gilts that stood immobile within 24 hours of slaughter were considered to have attained puberty (n=8/study). Plasma samples were collected on d 1, 3, and 7 of the first study and d 2, 4, 6, and 8 of the second study. When gilts were slaughtered in both studies, MBH, AP, and blood were collected. Relative expression of MBH Kiss1 and beta-actin and AP GnRHR, LH-beta, and beta-actin was determined using real-time reverse transcriptase PCR. Fold changes in relative expression were determined using the Relative Expression Software Tool. Hypothalamic and AP content of kisspeptin were determined by RIA and differences were determined using the GLIMMIX procedure of SAS. Relative expression of Kiss1 was increased (P=0.005) 2.2 fold in the gilts that had attained puberty in the first study, however, was not different (P=0.16) when comparing treatments in the second study. Relative expression of… Advisors/Committee Members: Jeffrey A. Clapper.

Subjects/Keywords: gilt; hypothalamus; Kisspeptin; Kisspeptin receptor; pig; pituitary; Animal Sciences; Physiology

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Jolitz, E. S. (2016). Evaluation of the Hypothalamic Kisspeptin System Throughout the Estrous Cycle and During the Attainment of Puberty in Gilts. (Masters Thesis). South Dakota State University. Retrieved from https://openprairie.sdstate.edu/etd/1004

Chicago Manual of Style (16^th Edition):

Jolitz, Eric Steven. “Evaluation of the Hypothalamic Kisspeptin System Throughout the Estrous Cycle and During the Attainment of Puberty in Gilts.” 2016. Masters Thesis, South Dakota State University. Accessed January 18, 2021. https://openprairie.sdstate.edu/etd/1004.

MLA Handbook (7^th Edition):

Jolitz, Eric Steven. “Evaluation of the Hypothalamic Kisspeptin System Throughout the Estrous Cycle and During the Attainment of Puberty in Gilts.” 2016. Web. 18 Jan 2021.

Vancouver:

Jolitz ES. Evaluation of the Hypothalamic Kisspeptin System Throughout the Estrous Cycle and During the Attainment of Puberty in Gilts. [Internet] [Masters thesis]. South Dakota State University; 2016. [cited 2021 Jan 18]. Available from: https://openprairie.sdstate.edu/etd/1004.

Council of Science Editors:

Jolitz ES. Evaluation of the Hypothalamic Kisspeptin System Throughout the Estrous Cycle and During the Attainment of Puberty in Gilts. [Masters Thesis]. South Dakota State University; 2016. Available from: https://openprairie.sdstate.edu/etd/1004

Michigan State University

8. Fiel, Nicholas J. Effects of starvation, thiouracil, thyroidectomy and thyroxine on hypothalmic content of "somatotropin releasing factor" and pituitary growth hormone content.

Degree: MS, Dept. of Physiology, 1965, Michigan State University

URL: http://etd.lib.msu.edu/islandora/object/etd:9598

Subjects/Keywords: Pituitary gland; Hypothalamus; Starvation

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APA (6^th Edition):

Fiel, N. J. (1965). Effects of starvation, thiouracil, thyroidectomy and thyroxine on hypothalmic content of "somatotropin releasing factor" and pituitary growth hormone content. (Masters Thesis). Michigan State University. Retrieved from http://etd.lib.msu.edu/islandora/object/etd:9598

Chicago Manual of Style (16^th Edition):

Fiel, Nicholas J. “Effects of starvation, thiouracil, thyroidectomy and thyroxine on hypothalmic content of "somatotropin releasing factor" and pituitary growth hormone content.” 1965. Masters Thesis, Michigan State University. Accessed January 18, 2021. http://etd.lib.msu.edu/islandora/object/etd:9598.

MLA Handbook (7^th Edition):

Fiel, Nicholas J. “Effects of starvation, thiouracil, thyroidectomy and thyroxine on hypothalmic content of "somatotropin releasing factor" and pituitary growth hormone content.” 1965. Web. 18 Jan 2021.

Vancouver:

Fiel NJ. Effects of starvation, thiouracil, thyroidectomy and thyroxine on hypothalmic content of "somatotropin releasing factor" and pituitary growth hormone content. [Internet] [Masters thesis]. Michigan State University; 1965. [cited 2021 Jan 18]. Available from: http://etd.lib.msu.edu/islandora/object/etd:9598.

Council of Science Editors:

Fiel NJ. Effects of starvation, thiouracil, thyroidectomy and thyroxine on hypothalmic content of "somatotropin releasing factor" and pituitary growth hormone content. [Masters Thesis]. Michigan State University; 1965. Available from: http://etd.lib.msu.edu/islandora/object/etd:9598

9. Anesiadou, Sophia. Ενσυναίσθηση και ηθική κρίση σε παιδιά σχολικής ηλικίας με διαταραχές στο φάσμα του αυτισμού, διαταραχή ελλειμματικής προσοχής υπερκινητικότητας και μαθησιακές δυσκολίες: ο ρόλος του στρες.

Degree: 2020, National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ)

URL: http://hdl.handle.net/10442/hedi/47854

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There is evidence that children with neurodevelopmental disorders may exhibit atypical responses to stress and alterations in concentrations and diurnal secretion of stress hormones. We… (more)

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There is evidence that children with neurodevelopmental disorders may exhibit atypical responses to stress and alterations in concentrations and diurnal secretion of stress hormones. We assessed diurnal profiles and stress responses of salivary cortisol and α-amylase (sAA) in children with attention deficit hyperactivity disorder (ADHD), autism spectrum disorder (ASD), and specific learning disorder (SLD) compared to typically developing children (TD). A total of 157 children of both sexes, aged between 6 and 12 years old, took part in the study distributed into four groups: ADHD (N=34), ASD (N=56), SLD (N=43), TD (N=24). Salivary samples were collected at three time points during a day, as well as before and 5 min after an academic performance test and a moral cognition task. ADHD children had lower evening and diurnal sAA levels, adjusted for age. Also, ASD children showed lower diurnal sAA secretion, adjusted for age. The mean percentage change for salivary cortisol and sAA after both tests did not differ between the groups. In conclusion, we demonstrated alterations in diurnal autonomic functioning in children with ADHD and ASD, while HPA axis functioning did not differ between the clinical and the comparison groups.

Υπάρχουν ενδείξεις ότι τα παιδιά με νευροαναπτυξιακές διαταραχές μπορεί να παρουσιάζουν άτυπες απαντήσεις στο στρες και μεταβολές στις συγκεντρώσεις και την ημερήσια έκκριση των ορμονών του στρες. Αξιολογήσαμε το ημερήσιο προφίλ και την απάντηση στο στρες της κορτιζόλης σιέλου και της α-αμυλάσης σε παιδιά με Διαταραχή Υπερκινητικότητας/Ελλειμματικής Προσοχής (ΔΕΠΥ), με Διαταραχή στο Φάσμα του Αυτισμού (ΔΦΑ), και σε παιδιά με Ειδικές Μαθησιακές Δυσκολίες (ΕΜΔ) έναντι των Τυπικά αναπτυσσόμενων παιδιών (TΑ). Συνολικά 157 παιδιά και των δύο φύλων, ηλικίας μεταξύ 6 και 12 ετών, συμμετείχαν στη μελέτη που κατανεμήθηκαν σε τέσσερις ομάδες: ΔΕΠΥ (N=34), ΔΦΑ (N=56), ΕΜΔ (N=43), TΑ (N=24). Τα δείγματα σιέλου συλλέχθηκαν σε τρία χρονικά σημεία κατά τη διάρκεια μιας ημέρας, καθώς και 5 λεπτά πριν και μετά από μια δοκιμασία ακαδημαϊκών επιδόσεων και μια ηθική-γνωστική δοκιμασία. Τα παιδιά με ΔΕΠΥ είχαν χαμηλότερα βραδινά και ημερήσια επίπεδα α-αμυλάσης σιέλου, προσαρμοσμένα ως προς την ηλικία. Επίσης, τα παιδιά με ΔΑΦ έδειξαν χαμηλότερη ημερήσια έκκριση α-αμυλάσης σιέλου, προσαρμοσμένη για την ηλικία. Η μέση ποσοστιαία μεταβολή για την κορτιζόλη σιέλου και την α-αμυλάση μετά τις δύο δοκιμασίες δεν διέφερε μεταξύ των ομάδων. Εν κατακλείδι, καταδείξαμε μεταβολές στην ημερήσια αυτόνομη λειτουργία σε παιδιά με ΔΕΠΥ και ΔΦΑ, ενώ η λειτουργία του άξονα Υποθάλαμος Υπόφυση Επινεφρίδια (ΥΥΕ) δε διέφερε μεταξύ των κλινικών και της ομάδας σύγκρισης.

Subjects/Keywords: Νευροαναπτυξιακές διαταραχές; Ενσυναίσθηση; Άξονας υποθάλαμος - υπόφυση - επινεφρίδια; Neurodevelopmental disorders; Empathy; Hypothalamus pituitary adrenal axis

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Anesiadou, S. (2020). Ενσυναίσθηση και ηθική κρίση σε παιδιά σχολικής ηλικίας με διαταραχές στο φάσμα του αυτισμού, διαταραχή ελλειμματικής προσοχής υπερκινητικότητας και μαθησιακές δυσκολίες: ο ρόλος του στρες. (Thesis). National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ). Retrieved from http://hdl.handle.net/10442/hedi/47854

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Anesiadou, Sophia. “Ενσυναίσθηση και ηθική κρίση σε παιδιά σχολικής ηλικίας με διαταραχές στο φάσμα του αυτισμού, διαταραχή ελλειμματικής προσοχής υπερκινητικότητας και μαθησιακές δυσκολίες: ο ρόλος του στρες.” 2020. Thesis, National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ). Accessed January 18, 2021. http://hdl.handle.net/10442/hedi/47854.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Anesiadou, Sophia. “Ενσυναίσθηση και ηθική κρίση σε παιδιά σχολικής ηλικίας με διαταραχές στο φάσμα του αυτισμού, διαταραχή ελλειμματικής προσοχής υπερκινητικότητας και μαθησιακές δυσκολίες: ο ρόλος του στρες.” 2020. Web. 18 Jan 2021.

Vancouver:

Anesiadou S. Ενσυναίσθηση και ηθική κρίση σε παιδιά σχολικής ηλικίας με διαταραχές στο φάσμα του αυτισμού, διαταραχή ελλειμματικής προσοχής υπερκινητικότητας και μαθησιακές δυσκολίες: ο ρόλος του στρες. [Internet] [Thesis]. National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ); 2020. [cited 2021 Jan 18]. Available from: http://hdl.handle.net/10442/hedi/47854.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Anesiadou S. Ενσυναίσθηση και ηθική κρίση σε παιδιά σχολικής ηλικίας με διαταραχές στο φάσμα του αυτισμού, διαταραχή ελλειμματικής προσοχής υπερκινητικότητας και μαθησιακές δυσκολίες: ο ρόλος του στρες. [Thesis]. National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ); 2020. Available from: http://hdl.handle.net/10442/hedi/47854

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Leiden University

10. Dijk, Suzanne Elise. Hypothalamus and pituitary volume in children with Prader-Willi Syndrome: A structural MRI study.

Degree: 2015, Leiden University

URL: http://hdl.handle.net/1887/34636

Subjects/Keywords: Prader-Willi Syndrome; MRI; hypothalamus; pituitary

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Dijk, S. E. (2015). Hypothalamus and pituitary volume in children with Prader-Willi Syndrome: A structural MRI study. (Masters Thesis). Leiden University. Retrieved from http://hdl.handle.net/1887/34636

Chicago Manual of Style (16^th Edition):

Dijk, Suzanne Elise. “Hypothalamus and pituitary volume in children with Prader-Willi Syndrome: A structural MRI study.” 2015. Masters Thesis, Leiden University. Accessed January 18, 2021. http://hdl.handle.net/1887/34636.

MLA Handbook (7^th Edition):

Dijk, Suzanne Elise. “Hypothalamus and pituitary volume in children with Prader-Willi Syndrome: A structural MRI study.” 2015. Web. 18 Jan 2021.

Vancouver:

Dijk SE. Hypothalamus and pituitary volume in children with Prader-Willi Syndrome: A structural MRI study. [Internet] [Masters thesis]. Leiden University; 2015. [cited 2021 Jan 18]. Available from: http://hdl.handle.net/1887/34636.

Council of Science Editors:

Dijk SE. Hypothalamus and pituitary volume in children with Prader-Willi Syndrome: A structural MRI study. [Masters Thesis]. Leiden University; 2015. Available from: http://hdl.handle.net/1887/34636

11. Klijn, Jan. Diagnosis and treatment of pituitary tumours: a starting-point for manipulation of cancer with hypothalamic hormones.

Degree: Department of Internal Medicine, 1987, Erasmus University Medical Center

URL: http://hdl.handle.net/1765/51185

► textabstractIn order to make a well-founded choice between the therapeutic modalities presently available it is important to have a clear picture of the differences in… (more)

Subjects/Keywords: pituitary tumour; gland; hypothalamus; pharmacotherapy; hormones

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APA (6^th Edition):

Klijn, J. (1987). Diagnosis and treatment of pituitary tumours: a starting-point for manipulation of cancer with hypothalamic hormones. (Doctoral Dissertation). Erasmus University Medical Center. Retrieved from http://hdl.handle.net/1765/51185

Chicago Manual of Style (16^th Edition):

Klijn, Jan. “Diagnosis and treatment of pituitary tumours: a starting-point for manipulation of cancer with hypothalamic hormones.” 1987. Doctoral Dissertation, Erasmus University Medical Center. Accessed January 18, 2021. http://hdl.handle.net/1765/51185.

MLA Handbook (7^th Edition):

Klijn, Jan. “Diagnosis and treatment of pituitary tumours: a starting-point for manipulation of cancer with hypothalamic hormones.” 1987. Web. 18 Jan 2021.

Vancouver:

Klijn J. Diagnosis and treatment of pituitary tumours: a starting-point for manipulation of cancer with hypothalamic hormones. [Internet] [Doctoral dissertation]. Erasmus University Medical Center; 1987. [cited 2021 Jan 18]. Available from: http://hdl.handle.net/1765/51185.

Council of Science Editors:

Klijn J. Diagnosis and treatment of pituitary tumours: a starting-point for manipulation of cancer with hypothalamic hormones. [Doctoral Dissertation]. Erasmus University Medical Center; 1987. Available from: http://hdl.handle.net/1765/51185

University of Illinois – Urbana-Champaign

12. Mommer, Brett. The neuroendocrine and molecular mechanisms underlying stress-induced maternal effects in the threespine stickleback.

Degree: PhD, 0314, 2013, University of Illinois – Urbana-Champaign

URL: http://hdl.handle.net/2142/45548

► Non-genetic maternal effects occur when offspring phenotype is influenced non-genetically by a mother’s phenotype. Exposure of mothers to external stressors, for example, can influence the… (more)

▼ Non-genetic maternal effects occur when offspring phenotype is influenced non-genetically by a mother’s phenotype. Exposure of mothers to external stressors, for example, can influence the expression of a wide array of offspring traits essential for survival, including growth, morphology, and behavior. In fact the exposure of mothers to an ecologically relevant stressor such as a non-lethal predator attack can alter the life-long offspring physiological and behavioral response to the same stressor. The transfer of information about the environment from a mother to her offspring, though, likely depends on the nature of her physical and behavioral contact with them, which in turn depends on the life history of the species. Mothers of many mammalian species, for example, care for offspring postnatally in addition to providing pre- and postnatal resources. The fact that stress-induced maternal effects occur in non-mammalian vertebrates, including many oviparous species that do not exhibit maternal care, indicates that the transgenerational transfer of information can occur entirely through the egg. Little is known, however, about the mechanisms by which mothers transmit information about the environment through the egg or how this information, once received by offspring, influences their phenotype non-genetically. For my PhD research I studied maternal effects in threespine sticklebacks (Gasterosteus aculeatus), with the goal to describe a maternal effect on the physiological stress response and the underlying molecular mechanisms by which the non-genetic maternal effects on physiology and behavior occur in sticklebacks. Sticklebacks are an oviparous fish that do not exhibit maternal care. Further, they are a model species in the study of behavior, easily acclimate and reproduce in a lab setting, and now have a fully sequenced genome, making the species an ideal candidate for the study maternal effects using techniques in genetics, physiology, and behavior. Previous studies in sticklebacks have shown that maternal exposure to predation risk increases the amount of cortisol, a stress hormone, in eggs and affects offspring antipredator behavior, learning, and survival in the presence of live predation. The physiological stress response, coordinated by the hypothalamus-pituitary-interrenal (HPI) axis, is the biological link between the recognition of external stressors by the brain and the broad homeostatic changes that occur in the body in response to those stressors. The diversity of offspring behavioral responses to maternal stress in sticklebacks therefore suggests organizational effects on the HPI axis, though to date this has not been tested. Therefore the first chapter of my thesis (Chapter 2) tested the hypothesis that maternal exposure to predation risk has long-lasting effects on the stress response of offspring in sticklebacks. To accomplish this I exposed adult offspring of predator-exposed mothers and control mothers to a simulated predator attack and measured circulating cortisol at multiple time… Advisors/Committee Members: Bell, Alison M. (advisor), Bell, Alison M. (Committee Chair), Fuller, Rebecca C. (committee member), Stubbs, Lisa J. (committee member), Whitfield, Charles W. (committee member).

Subjects/Keywords: parental effect; glucocorticoid; hypothalamus-pituitary-interrenal (HPI) axis; predators; maternal programming; transcriptome

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Mommer, B. (2013). The neuroendocrine and molecular mechanisms underlying stress-induced maternal effects in the threespine stickleback. (Doctoral Dissertation). University of Illinois – Urbana-Champaign. Retrieved from http://hdl.handle.net/2142/45548

Chicago Manual of Style (16^th Edition):

Mommer, Brett. “The neuroendocrine and molecular mechanisms underlying stress-induced maternal effects in the threespine stickleback.” 2013. Doctoral Dissertation, University of Illinois – Urbana-Champaign. Accessed January 18, 2021. http://hdl.handle.net/2142/45548.

MLA Handbook (7^th Edition):

Mommer, Brett. “The neuroendocrine and molecular mechanisms underlying stress-induced maternal effects in the threespine stickleback.” 2013. Web. 18 Jan 2021.

Vancouver:

Mommer B. The neuroendocrine and molecular mechanisms underlying stress-induced maternal effects in the threespine stickleback. [Internet] [Doctoral dissertation]. University of Illinois – Urbana-Champaign; 2013. [cited 2021 Jan 18]. Available from: http://hdl.handle.net/2142/45548.

Council of Science Editors:

Mommer B. The neuroendocrine and molecular mechanisms underlying stress-induced maternal effects in the threespine stickleback. [Doctoral Dissertation]. University of Illinois – Urbana-Champaign; 2013. Available from: http://hdl.handle.net/2142/45548

13. Agnew, Robert Laing. Some Effects of X-Irradiaion on the Adrenal Response to Hypothalamic Stimulation in Rats.

Degree: 1967, North Texas State University

URL: https://digital.library.unt.edu/ark:/67531/metadc163900/

► Exactly where in the hypothalamus is the adrenal-pituitary response to X-irradiation "triggered" or initiated? Moreover, does ionizing radiation act directly on specific centers in the… (more)

Subjects/Keywords: X-irradiation; hypothalamus; adrenal-pituitary; rats

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APA (6^th Edition):

Agnew, R. L. (1967). Some Effects of X-Irradiaion on the Adrenal Response to Hypothalamic Stimulation in Rats. (Thesis). North Texas State University. Retrieved from https://digital.library.unt.edu/ark:/67531/metadc163900/

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Agnew, Robert Laing. “Some Effects of X-Irradiaion on the Adrenal Response to Hypothalamic Stimulation in Rats.” 1967. Thesis, North Texas State University. Accessed January 18, 2021. https://digital.library.unt.edu/ark:/67531/metadc163900/.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Agnew, Robert Laing. “Some Effects of X-Irradiaion on the Adrenal Response to Hypothalamic Stimulation in Rats.” 1967. Web. 18 Jan 2021.

Vancouver:

Agnew RL. Some Effects of X-Irradiaion on the Adrenal Response to Hypothalamic Stimulation in Rats. [Internet] [Thesis]. North Texas State University; 1967. [cited 2021 Jan 18]. Available from: https://digital.library.unt.edu/ark:/67531/metadc163900/.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Agnew RL. Some Effects of X-Irradiaion on the Adrenal Response to Hypothalamic Stimulation in Rats. [Thesis]. North Texas State University; 1967. Available from: https://digital.library.unt.edu/ark:/67531/metadc163900/

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Vanderbilt University

14. Laryea, Gloria Naa Atswei. Regulation of the hypothalamic-pitutary-adrenal axis by the glucocorticoid receptor and corticotropin-releasing hormone.

Degree: PhD, Neuroscience, 2014, Vanderbilt University

URL: http://hdl.handle.net/1803/13841

► Stress often precipitates or exacerbates mental illness. The hypothalamic-pituitary-adrenal (HPA) axis is the canonical pathway that mediates an organism’s response to stress. Acute stress increases… (more)

▼ Stress often precipitates or exacerbates mental illness. The hypothalamic-pituitary-adrenal (HPA) axis is the canonical pathway that mediates an organism’s response to stress. Acute stress increases HPA axis activity, leading to short-term increases in plasma glucocorticoid (GC) levels. While short term increases in GC are beneficial because it prepares an organism to adequately respond to the stressor, long-term increases in GC results in damaging effects in the brain and periphery leading to disease. Effective negative feedback by GC acting on glucocorticoid receptors (GR) in the paraventricular nucleus of the hypothalamus (PVN) and anterior pituitary is essential to prevent the deleterious effects of excess GC. In the first part of this dissertation, we investigate the effects of disrupted negative feedback at the level of the PVN on behavior and neuroendocrine activity. Using mice that express Cre-recombinase primarily in the PVN (Sim1Cre) in combination with floxed-GR mice, we delete GR specifically in the PVN. PVN GR deletion (Sim1Cre-GRe3Ä) disrupted negative feedback of GC secretion, and resulted in elevated morning and evening levels of GC in adult mice. There was also augmented stress-induced GC increases as a result of PVN GR loss in adult mice that did not occur during adolescent. In adolescence, we observed gender-specific differences in basal and stress-induced HPA axis regulation. Despite HPA axis hyperactivation and impaired negative feedback in adult Sim1Cre-GRe3Ä mice, basal anxiety and despair behavior were unaltered in adulthood, but we identified potential a gene x environment interactions that cause increased anxiety in Sim1Cre-GRe3Ä mice in an anxiogenic settings. HPA axis hyperactivity is associated with altered activity in limbic regions, such as increased mRNA levels of corticotropin-releasing hormone (CRH) in the central nucleus of the amygdala (CeA). In part 2 of this dissertation, we use lentivirus-induced overexpression of CRH in the CeA of adolescent mice in an effort to isolate the contributions of CeA CRH in the development of stress-related pathology. These studies provide evidence for the role of GR and CRH signaling in HPA axis and behavior regulation. Advisors/Committee Members: Jeremy Veenstra-VanderWeele (committee member), Kevin Niswender (committee member), Louis Muglia (committee member), Danny Winder (Committee Chair).

Subjects/Keywords: Paraventricular Nucleus of the Hypothalamus; Adrenocorticotropic Hormone; Corticotropin-Releasing Hormone; Glucocorticoid Receptor; Hypothalamic-Pituitary-Adrenal Axis; Corticosterone; Metabolism; Stress; Pituitary; Circadian Regulation

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Laryea, G. N. A. (2014). Regulation of the hypothalamic-pitutary-adrenal axis by the glucocorticoid receptor and corticotropin-releasing hormone. (Doctoral Dissertation). Vanderbilt University. Retrieved from http://hdl.handle.net/1803/13841

Chicago Manual of Style (16^th Edition):

Laryea, Gloria Naa Atswei. “Regulation of the hypothalamic-pitutary-adrenal axis by the glucocorticoid receptor and corticotropin-releasing hormone.” 2014. Doctoral Dissertation, Vanderbilt University. Accessed January 18, 2021. http://hdl.handle.net/1803/13841.

MLA Handbook (7^th Edition):

Laryea, Gloria Naa Atswei. “Regulation of the hypothalamic-pitutary-adrenal axis by the glucocorticoid receptor and corticotropin-releasing hormone.” 2014. Web. 18 Jan 2021.

Vancouver:

Laryea GNA. Regulation of the hypothalamic-pitutary-adrenal axis by the glucocorticoid receptor and corticotropin-releasing hormone. [Internet] [Doctoral dissertation]. Vanderbilt University; 2014. [cited 2021 Jan 18]. Available from: http://hdl.handle.net/1803/13841.

Council of Science Editors:

Laryea GNA. Regulation of the hypothalamic-pitutary-adrenal axis by the glucocorticoid receptor and corticotropin-releasing hormone. [Doctoral Dissertation]. Vanderbilt University; 2014. Available from: http://hdl.handle.net/1803/13841

University of Arizona

15. Pamenter, Richard William. PHYSIOLOGICAL CONTROL OF THE HYPOTHALAMIC - PITUITARY - THYROID AXIS .

Degree: 1981, University of Arizona

URL: http://hdl.handle.net/10150/282075

► The hypothalamic-pituitary-thyroid axis operates to maintain the circulating concentration of thyroid hormones. Thyrotropin releasing hormone (TRH) is the major hypothalamic messenger controlling the pituitary-thyroid unit.… (more)

▼ The hypothalamic-pituitary-thyroid axis operates to maintain the circulating concentration of thyroid hormones. Thyrotropin releasing hormone (TRH) is the major hypothalamic messenger controlling the pituitary-thyroid unit. However, the pituitary-thyroid unit responses to various modalities of TRH exposure are not well characterized. Also, interactions between the thyroid axis and other mammalian organ systems, specifically other hormone axes, to maintain the organism's homeostatic state are not well characterized. This work was designed to clarify the response of the pituitary-thyroid unit to TRH and to assess the effects of physiological levels of the rat's primary adrenal cortical hormone, corticosterone, on the thyroid axis. Adult rats were given equal amounts of TRH by intravenous (I.V.) bolus injection or constant intraperitoneal (I.P.) infusion. Both methods resulted in significant increases in plasma thyroid stimulating hormone (TSH), although the time course and peak plasma value varied with the TRH dosage and administration method. Despite the differences in plasma TSH elicited, the thyroid gland responses were similar. Thus, the pituitary is sensitive to the rate and dose of TRH administration. Also, the thyroid is sensitive to plasma levels of TSH but reaches maximum stimulation at submaximal circulating TSH levels. Adrenalectomized female rats, with I.P. and I.V. catheters, were infused with corticosterone (B) to achieve plasma levels within the rat's physiological range. Plasma samples were drawn before and after submaximal TRH (250 ng/100 g Body Weight) administration for assay of TSH and B concentrations. B in the lower half of its physiological range significantly inhibited the increase in plasma TSH observed 10 and 30 minutes after TRH administration. Also, direct stereotaxic infusion of B (50 ng) followed by TRH (1 ng) into the anterior pituitary inhibited the observed increase in plasma TSH. These studies indicate that homeostatic thyroid axis hormone concentrations are maintained by a feedback loop mechanism which is modulated by adrenal hormones. Specifically, physiological levels of corticosterone decrease pituitary sensitivity to TRH in the rat. In addition, the pituitary and thyroid gland exhibit different response patterns to hormonal stimulation. Advisors/Committee Members: Stouffer, Richard L (advisor).

Subjects/Keywords: Thyroid gland.; Pituitary gland.; Hypothalamus.; Thyroid hormones.; Pituitary hormones.; Hypothalamic hormones.

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Pamenter, R. W. (1981). PHYSIOLOGICAL CONTROL OF THE HYPOTHALAMIC - PITUITARY - THYROID AXIS . (Doctoral Dissertation). University of Arizona. Retrieved from http://hdl.handle.net/10150/282075

Chicago Manual of Style (16^th Edition):

Pamenter, Richard William. “PHYSIOLOGICAL CONTROL OF THE HYPOTHALAMIC - PITUITARY - THYROID AXIS .” 1981. Doctoral Dissertation, University of Arizona. Accessed January 18, 2021. http://hdl.handle.net/10150/282075.

MLA Handbook (7^th Edition):

Pamenter, Richard William. “PHYSIOLOGICAL CONTROL OF THE HYPOTHALAMIC - PITUITARY - THYROID AXIS .” 1981. Web. 18 Jan 2021.

Vancouver:

Pamenter RW. PHYSIOLOGICAL CONTROL OF THE HYPOTHALAMIC - PITUITARY - THYROID AXIS . [Internet] [Doctoral dissertation]. University of Arizona; 1981. [cited 2021 Jan 18]. Available from: http://hdl.handle.net/10150/282075.

Council of Science Editors:

Pamenter RW. PHYSIOLOGICAL CONTROL OF THE HYPOTHALAMIC - PITUITARY - THYROID AXIS . [Doctoral Dissertation]. University of Arizona; 1981. Available from: http://hdl.handle.net/10150/282075

16. Cassoli, Clarissa Sanches da Silva. Identificação e análise de etiquetas de seqüências expressas (ESTs) na hipófise e hipotálamo de Gallus gallus.

Degree: PhD, Ciência Animal e Pastagens, 2007, University of São Paulo

URL: http://www.teses.usp.br/teses/disponiveis/11/11139/tde-11062007-114707/ ;

►

A avicultura brasileira tem alcançado altos índices de desempenho na produção de carne e ovos, como resultado da atualização constante de tecnologias no setor. A… (more)

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A avicultura brasileira tem alcançado altos índices de desempenho na produção de carne e ovos, como resultado da atualização constante de tecnologias no setor. A biotecnologia vem contribuindo nesse sentido, atuando especialmente em programas de seleção de animais com maior potencial de desenvolvimento e crescimento. Como toda a fisiologia animal é controlada direta e/ou indiretamente pela hipófise e hipotálamo, este trabalho propôs identificar e analisar genes expressos nestas estruturas de galinhas de duas linhagens divergentes quanto ao potencial de crescimento e avaliar a expressão dos genes correspondentes a transcritos cuja identidade não pôde ser revelada (sem similar nos bacos de dados), uma vez que estes podem representar possíveis genes novos. Para isto, foram construídas e analisadas bibliotecas a partir da hipófise e hipotálamo de aves de 21 dias de idade de uma linha macho de corte (TT) e uma linhagem de postura (CC), provenientes da Embrapa Suínos e Aves. Um total de 4.286 ESTs válidas foi obtido (no mínimo150 pb com qualidade PHRED acima de 20), correspondendo a 2.133 ESTs da biblioteca da linhagem TT e 2.153 ESTs da biblioteca da linhagem CC. O exercício de montagem, via programa Cap3, revelou 3.074 seqüências únicas, sendo 1.643 da biblioteca da linhagem TT e 1.649 da CC. Estas seqüências únicas foram automaticamente classificadas, de acordo com as categorias do GeneOntology, sendo que as seqüências de ambas as bibliotecas apresentaram uma distribuição similar entre os termos. Após montagem das ESTs e análise do padrão de expressão digital das seqüências constituintes, dos 389 contigs obtidos, 194 foram compostos por seqüências diferencialmente expressas entre as bibliotecas. Foram detectados 28 contigs contendo SNPs linhagem específicos, sendo 52 SNPs TT específicos e 25 CC específicos. Um total de 146 ESTs não pôde ter sua identidade revelada, porém destas, 133 puderam ser localizadas no genoma da galinha e apresentaram pelo menos uma fase de leitura aberta (ORF). Após análise de expressão gênica, os genes correspondentes a 78 destas ESTs sem identidade apresentaram-se diferencialmente expressos entre pelo menos dois dos tecidos de aves de uma linhagem comercial de corte de 21 dias de idade estudados: hipófise, hipotálamo, cérebro, fígado e músculo. Os resultados apresentados são promissores e merecem ser investigados em estudos futuros com o objetivo de identificar marcadores moleculares para programas de seleção e melhoramento animal.

The brazilian aviculture has reached a high development level in both meat and egg production as a result of constant technological atualization in the sector. Biotechnology can contribute in this way acting in selection programs of animals that show higher growth and development potential. The global animal physiology is direct or indirectly controlled by pituitary and hypothalamus. The aim of this work was to identify and analyse genes expressed in these structures of two divergent line chickens according to growth potential and evaluate the gene expression of…

Advisors/Committee Members: Coutinho, Luiz Lehmann.

Subjects/Keywords: Gallus gallus; ESTs; Expressão gênica; Frango de corte; Gene expression; Genomas; Hipófise; Hipotálamo; Hypothalamus; Pituitary; Sequenciamento

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Cassoli, C. S. d. S. (2007). Identificação e análise de etiquetas de seqüências expressas (ESTs) na hipófise e hipotálamo de Gallus gallus. (Doctoral Dissertation). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/11/11139/tde-11062007-114707/ ;

Chicago Manual of Style (16^th Edition):

Cassoli, Clarissa Sanches da Silva. “Identificação e análise de etiquetas de seqüências expressas (ESTs) na hipófise e hipotálamo de Gallus gallus.” 2007. Doctoral Dissertation, University of São Paulo. Accessed January 18, 2021. http://www.teses.usp.br/teses/disponiveis/11/11139/tde-11062007-114707/ ;.

MLA Handbook (7^th Edition):

Cassoli, Clarissa Sanches da Silva. “Identificação e análise de etiquetas de seqüências expressas (ESTs) na hipófise e hipotálamo de Gallus gallus.” 2007. Web. 18 Jan 2021.

Vancouver:

Cassoli CSdS. Identificação e análise de etiquetas de seqüências expressas (ESTs) na hipófise e hipotálamo de Gallus gallus. [Internet] [Doctoral dissertation]. University of São Paulo; 2007. [cited 2021 Jan 18]. Available from: http://www.teses.usp.br/teses/disponiveis/11/11139/tde-11062007-114707/ ;.

Council of Science Editors:

Cassoli CSdS. Identificação e análise de etiquetas de seqüências expressas (ESTs) na hipófise e hipotálamo de Gallus gallus. [Doctoral Dissertation]. University of São Paulo; 2007. Available from: http://www.teses.usp.br/teses/disponiveis/11/11139/tde-11062007-114707/ ;

17. Costa, Helder Cravo da. Caracterização da origem das fibras imunorreativas ao hormônio concentrador de melanina na lâmina interna da eminência mediana e na hipófise posterior durante a lactação em ratas Long-Evans (Rattus norvegicus).

Degree: Mestrado, Ciências Morfofuncionais, 2013, University of São Paulo

URL: http://www.teses.usp.br/teses/disponiveis/42/42131/tde-14032014-085532/ ;

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A parte ventral da área pré-óptica medial (MPOA) apresenta o RNAm do prépró-hormônio concentrador de melanina (ppMCH) e o MCH apenas durante a lactação, especialmente… (more)

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A parte ventral da área pré-óptica medial (MPOA) apresenta o RNAm do prépró-hormônio concentrador de melanina (ppMCH) e o MCH apenas durante a lactação, especialmente entre os dias 19º e 21º. Fibras imunorreativas ao MCH (MCH-ir) e ocitocinérgicas (OT-ir) de origem desconhecida transitam na lâmina interna da eminência mediana (MEi) e na hipófise posterior (PPit). Utilizamos ratas lactantes da linhagem Long-Evans para identificar a origem dessas fibras, caracterizar sua relação na MEi e PPit e quantificar o ppMCH e OT na PPit. A imuno-histoquímica mostrou que não há colocalização entre as fibras MCH-ir e OT-i e há uma proximidade entre suas fibras na MEi e PPit. A dupla hibridização in situ e imuno-histoquímica mostrou que os neurônios retrogradamente marcados com FG após injeção intravascular expressam o RNAm do ppMCH na MPOA e no núcleo paraventricular do hipotálamo. O Western Blotting mostrou uma maior presença do ppMCH na PPit no 19º dia de lactação. Os dados sugerem que o MCH atua no controle neuroendócrino para o término do período de lactação.

The ventral part of the medial preoptic area (MPOA) has been described as the novel harbor of the expression of prepro-melanin-concentrating hormone (ppMCH) mRNA and MCH peptide, only during the end of lactation, especially between the 19th and 21st days. MCH-ir and OT-ir fibers are described as passing in the internal layer of the median eminence (MEi). However, the origin of MCH-ir fibers and its possible relationship with the OT-ir fibers are not known. Long-Evans rats were used to identify the origin of these fibers and characterize their relationship into MEi and PPit and quantify ppMCH and OT in PPit. Immunohistochemistry showed no colocalization between MCH-ir and OT-ir fibers, but a closeness between these fibers into MEi and PPit. Using a combination of in situ hybridization and immunohistochemistry we have showed that neurons retrogradely labeled with FG after intravascular injection express the ppMCH mRNA into MPOA and paraventricular nucleus of the hypothalamus. The Western blotting showed an increase of ppMCH in the PPit parallel with a decrease of OT-ir on the 19th day of lactation. The data suggest that MCH acts on the neuroendocrine control towards the end of the lactation period.

Advisors/Committee Members: Bittencourt, Jackson Cioni.

Subjects/Keywords: Animal maternal behavior; Comportamento materno animal; Glândula pituitária; Hipotálamo; Hypothalamus; Melaninas; Melanins; Ocitocina; Oxytocin; Pituitary gland

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Costa, H. C. d. (2013). Caracterização da origem das fibras imunorreativas ao hormônio concentrador de melanina na lâmina interna da eminência mediana e na hipófise posterior durante a lactação em ratas Long-Evans (Rattus norvegicus). (Masters Thesis). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/42/42131/tde-14032014-085532/ ;

Chicago Manual of Style (16^th Edition):

Costa, Helder Cravo da. “Caracterização da origem das fibras imunorreativas ao hormônio concentrador de melanina na lâmina interna da eminência mediana e na hipófise posterior durante a lactação em ratas Long-Evans (Rattus norvegicus).” 2013. Masters Thesis, University of São Paulo. Accessed January 18, 2021. http://www.teses.usp.br/teses/disponiveis/42/42131/tde-14032014-085532/ ;.

MLA Handbook (7^th Edition):

Costa, Helder Cravo da. “Caracterização da origem das fibras imunorreativas ao hormônio concentrador de melanina na lâmina interna da eminência mediana e na hipófise posterior durante a lactação em ratas Long-Evans (Rattus norvegicus).” 2013. Web. 18 Jan 2021.

Vancouver:

Costa HCd. Caracterização da origem das fibras imunorreativas ao hormônio concentrador de melanina na lâmina interna da eminência mediana e na hipófise posterior durante a lactação em ratas Long-Evans (Rattus norvegicus). [Internet] [Masters thesis]. University of São Paulo; 2013. [cited 2021 Jan 18]. Available from: http://www.teses.usp.br/teses/disponiveis/42/42131/tde-14032014-085532/ ;.

Council of Science Editors:

Costa HCd. Caracterização da origem das fibras imunorreativas ao hormônio concentrador de melanina na lâmina interna da eminência mediana e na hipófise posterior durante a lactação em ratas Long-Evans (Rattus norvegicus). [Masters Thesis]. University of São Paulo; 2013. Available from: http://www.teses.usp.br/teses/disponiveis/42/42131/tde-14032014-085532/ ;

University of Georgia

18. Li, Rong. Effects and mechanism of environmental and genetic factors on female puberty and reproduction.

Degree: 2017, University of Georgia

URL: http://hdl.handle.net/10724/36810

► Both environmental and genetic factors can affect female puberty and reproduction. In Chapter 1, these factors with focuses on one environmental factor, genistein, and one… (more)

▼ Both environmental and genetic factors can affect female puberty and reproduction. In Chapter 1, these factors with focuses on one environmental factor, genistein, and one genetic factor, olfactomedin 1 (OLFM1) are reviewed. In Chapter 2, the effects of postweaning dietary genistein exposure on female puberty and early pregnancy in C57BL/6J mice are studied. Dose-response study reveals that genistein diets (5-500 ppm) have dose-dependent effects on advancing age at vaginal opening, increasing duration of estrus stage, and accelerating mammary gland development; 5 ppm genistein diet promotes ovulation. Despite the effects on female puberty, postweaning dietary genistein exposure does not have significant effects on early pregnancy. In Chapter 3, the influence of body fat on the effects of genistein on female pubertal development is studied. Berardinelli-Seip Congenital Lipodystrophy 2 (Bscl2)-/- female mice with lipodystropy are used as a low body fat animal model. Postweaning 500 ppm genistein dietary exposure advances vaginal opening and increases mammary gland area in Bscl2-/- females. In Chapter 4, the function and mechanism of OLFM1 on female puberty and fertility using Olfm1-/- mouse model are investigated. Olfm1-/- females have delayed pubertal development and impaired fertility. Rescued ovulation and fertility by superovulation, normal basal Follicle-stimulating hormone (FSH) and Luteinizing hormone (LH) levels, and normal Gonadotropin-releasing hormone (GnRH) induced LH surge indicate a functional Hypothalamus-pituitary-gonad (HPG) axis. High expression level of OLFM1 in the olfactory systems, unresponsiveness to male bedding stimulation on estrous cycle and pubertal development in Olfm1-/- females coupled with a 41% reduction of cFOS positive cells in mitral layer of accessory olfactory bulb indicate that the function of OLFM1 in olfaction contributes to the defective pubertal development and fertility in Olfm1-/- female mice. In Chapter 5, the dissertation and future directions of study are summarized.

Subjects/Keywords: puberty; reproduction; genistein; vaginal opening; estrous cycle; ovulation; mammary gland; hypothalamus-pituitary-gonad axis; lipodystrophy; olfactomedin1; olfaction

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Li, R. (2017). Effects and mechanism of environmental and genetic factors on female puberty and reproduction. (Thesis). University of Georgia. Retrieved from http://hdl.handle.net/10724/36810

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Li, Rong. “Effects and mechanism of environmental and genetic factors on female puberty and reproduction.” 2017. Thesis, University of Georgia. Accessed January 18, 2021. http://hdl.handle.net/10724/36810.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Li, Rong. “Effects and mechanism of environmental and genetic factors on female puberty and reproduction.” 2017. Web. 18 Jan 2021.

Vancouver:

Li R. Effects and mechanism of environmental and genetic factors on female puberty and reproduction. [Internet] [Thesis]. University of Georgia; 2017. [cited 2021 Jan 18]. Available from: http://hdl.handle.net/10724/36810.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Li R. Effects and mechanism of environmental and genetic factors on female puberty and reproduction. [Thesis]. University of Georgia; 2017. Available from: http://hdl.handle.net/10724/36810

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Texas A&M University

19. Prezotto, Ligia Dias. Role of an Equine Homologue of Gonadotropin-Inhibiting Hormone in Controlling Sectretion of Luteinizing Hormone in the Mare.

Degree: MS, Physiology of Reproduction, 2012, Texas A&M University

URL: http://hdl.handle.net/1969.1/ETD-TAMU-2012-05-10918

► Four experiments were conducted to test the hypothesis that RF-amide related peptide 3 (RFRP3) negatively regulate the secretion of LH in mares. In Exp. 1,… (more)

▼ Four experiments were conducted to test the hypothesis that RF-amide related peptide 3 (RFRP3) negatively regulate the secretion of LH in mares. In Exp. 1, mares received native gonadotropin-releasing hormone (GnRH) continuously at a rate of 20 microgram/h, delivered subcutaneously using Alzet osmotic pumps during the luteal phase of the estrous cycle. Mares were treated with i.v. bolus injections of 0, 500 and 1,000 microgram eRFRP3 on days 4, 6 and 8 of cycle. Mean concentrations of LH in the peripheral circulation averaged 1.2 +/- 0.2 ng/mL and did not differ among groups before or following RFRP3 treatment. In Exp. 2, pituitary venous effluent was sampled for characterization of episodic release of LH. Mares received either saline or eRFRP3 (250 microgram) i.v. every 10 min for 6 h beginning 2 h after onset of sampling. At hour 6, each mare was challenged with 1 mg GnRH. Neither mean ICS concentrations of LH (1.3 +/- 0.2 ng/ml), nor frequency (3.6 +/- 0.55 episodes/h), amplitude (0.2 +/- 0.03 ng/ml), or duration (36.3 +/- 3.5 min) of individual secretory episodes, differed between groups before or after eRFRP3 treatment. Area under the GnRH-induced LH curve (arbitrary units) also did not differ between control and RFRP3 treated mares (175.9 +/- 11.4 vs. 192.6 +/- 10.6). In Exp. 3, winter anovulatory mares (n=6) were treated continuously for 7 d with GnRH (100 microgram/h) to stimulate synthesis of LH and increase circulating concentrations of LH to values similar to the breeding season. The ICS was catheterized for blood sampling and mares were treated with saline or RFRP3 (5 mg) in a replicated Latin square design. Treatment with RFRP3 failed to alter ICS mean concentration of LH (0.95 +/- .03 ng/ml). Finally in Exp. 4, mares in the follicular phase of the estrous cycle were assigned randomly to receive either saline (n=3) or 10 microgram/kg BW of oRFRP3 (n=3) in a single injection. No effect on mean concentration of LH was observed. In contrast to observations in birds and other mammals, results of the current experiments fail to provide evidence for functional activity of eRFRP3 or oRFRP3 in regulating LH release in the mare. Advisors/Committee Members: Amstalden, Marcel (advisor), Williams, Gary L. (advisor), Brinsko, Steven (committee member).

Subjects/Keywords: GnRH; LH; Hypothalamus; Pituitary; GnIH/RFRP3

…dorsomedial nucleus of the equine hypothalamus (arrows). (B) Double-label… …evidence that melatonin reduces GnRH content of the hypothalamus in mares [5] but a… …endogenous GnRH secretion, or involves changes in pituitary responsiveness. Using the… …anterior pituitary cells. The functional RF-amide was named, gonadotropin-inhibiting hormone… …pituitary, and inhibit LH release by direct actions in the pituitary [15, 16], their…

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Prezotto, L. D. (2012). Role of an Equine Homologue of Gonadotropin-Inhibiting Hormone in Controlling Sectretion of Luteinizing Hormone in the Mare. (Masters Thesis). Texas A&M University. Retrieved from http://hdl.handle.net/1969.1/ETD-TAMU-2012-05-10918

Chicago Manual of Style (16^th Edition):

Prezotto, Ligia Dias. “Role of an Equine Homologue of Gonadotropin-Inhibiting Hormone in Controlling Sectretion of Luteinizing Hormone in the Mare.” 2012. Masters Thesis, Texas A&M University. Accessed January 18, 2021. http://hdl.handle.net/1969.1/ETD-TAMU-2012-05-10918.

MLA Handbook (7^th Edition):

Prezotto, Ligia Dias. “Role of an Equine Homologue of Gonadotropin-Inhibiting Hormone in Controlling Sectretion of Luteinizing Hormone in the Mare.” 2012. Web. 18 Jan 2021.

Vancouver:

Prezotto LD. Role of an Equine Homologue of Gonadotropin-Inhibiting Hormone in Controlling Sectretion of Luteinizing Hormone in the Mare. [Internet] [Masters thesis]. Texas A&M University; 2012. [cited 2021 Jan 18]. Available from: http://hdl.handle.net/1969.1/ETD-TAMU-2012-05-10918.

Council of Science Editors:

Prezotto LD. Role of an Equine Homologue of Gonadotropin-Inhibiting Hormone in Controlling Sectretion of Luteinizing Hormone in the Mare. [Masters Thesis]. Texas A&M University; 2012. Available from: http://hdl.handle.net/1969.1/ETD-TAMU-2012-05-10918

20. Pivonello, Rosario. Dopamine receptor expression and function in the normal and pathological hypothalamus-pituitary-adrenal axis.

Degree: 2005, Erasmus University Medical Center

URL: http://hdl.handle.net/1765/76098

► markdownabstract__Abstract__ Dopamine is the predominant catecholamine neurotransmitter in the human central nervous system, where it controls a variety of functions including cognition, emotion, locomotor activity,… (more)

▼ markdownabstract__Abstract__ Dopamine is the predominant catecholamine neurotransmitter in the human central nervous system, where it controls a variety of functions including cognition, emotion, locomotor activity, food intake and endocrine regulation. Dopamine also plays multiple roles in the periphery as a modulator of cardiovascular and renal function, gastrointestinal motility and the endocrine system (1). Dopamine exerts its functions via the binding with dopamine receptors (1). Dopamine receptors belong to the family of seven transmembrane domain G protein-coupled receptors and include five different receptor subtypes, named D1-Ds. The members of dopamine receptor family are encoded by genes localized on different chromosome loci, displaying a considerable homology in their protein structure and function. The analysis of dopamine receptor structure and function suggests the existence of two different groups of receptors: D1-like, including D1 and D5 receptors, associated to a stimulatory function, and Dz-like, including Dz, D3 and D4 receptors, associated to an inhibitory function. The D1 and Ds receptors are encoded by intronless genes and share an 80% homology in their transmembrane domains. The Dz receptor shares a 75% homology with the D3 and a 53% homology with the D4 transmembrane domains and all three receptor subtypes are encoded by genes, which are interrupted by introns. The Dz receptor exists in two main variants, called Dzlong and Dzshort, generated by an alternative splicing of an 87 base pairs exon. These two D2 receptor isoforms differ for the presence or absence of a stretch of 29 amino acids in the third cytoplasmic loop in their protein structure. Splicing variants of the D3 receptor encoding nonfunctional proteins have been also identified. The analysis of the D4 receptor reveals the existence of polymorphic variations within the coding sequence, being a 48 base pairs sequence existent as a direct repeat sequence (D4.1), fourfold (D4.4), sevenfold (D4.7) or eleven fold (D4.11) repeat sequence. Therefore, the D4 receptor isoforms differ for the length of the third cytoplasmic loop and have one, four, seven or eleven times the same insert of a stretch of 19 amino acids in their protein structure. The Ds receptor has two related pseudogenes, which share a 95% homology with the gene and encode for truncated non functional forms of the receptor (1). The molecular characteristics of human dopamine receptor family are summarized in Table 1. A schematic representation of the human dopamine receptor is shown in Fig. 1.

Subjects/Keywords: dopamine; dopamine receptors; hypothalamus-pituitary-adrenal axis

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Pivonello, R. (2005). Dopamine receptor expression and function in the normal and pathological hypothalamus-pituitary-adrenal axis. (Doctoral Dissertation). Erasmus University Medical Center. Retrieved from http://hdl.handle.net/1765/76098

Chicago Manual of Style (16^th Edition):

Pivonello, Rosario. “Dopamine receptor expression and function in the normal and pathological hypothalamus-pituitary-adrenal axis.” 2005. Doctoral Dissertation, Erasmus University Medical Center. Accessed January 18, 2021. http://hdl.handle.net/1765/76098.

MLA Handbook (7^th Edition):

Pivonello, Rosario. “Dopamine receptor expression and function in the normal and pathological hypothalamus-pituitary-adrenal axis.” 2005. Web. 18 Jan 2021.

Vancouver:

Pivonello R. Dopamine receptor expression and function in the normal and pathological hypothalamus-pituitary-adrenal axis. [Internet] [Doctoral dissertation]. Erasmus University Medical Center; 2005. [cited 2021 Jan 18]. Available from: http://hdl.handle.net/1765/76098.

Council of Science Editors:

Pivonello R. Dopamine receptor expression and function in the normal and pathological hypothalamus-pituitary-adrenal axis. [Doctoral Dissertation]. Erasmus University Medical Center; 2005. Available from: http://hdl.handle.net/1765/76098

Michigan State University

21. Chen, Han-Tong. Role of serotonin and dopamine in gonadotropin release.

Degree: PhD, Department of Physiology, 1979, Michigan State University

URL: http://etd.lib.msu.edu/islandora/object/etd:42138

Subjects/Keywords: Gonadotropin; Serotonin; Dopamine; Pituitary hormone releasing factors; Hypothalamus

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Chen, H. (1979). Role of serotonin and dopamine in gonadotropin release. (Doctoral Dissertation). Michigan State University. Retrieved from http://etd.lib.msu.edu/islandora/object/etd:42138

Chicago Manual of Style (16^th Edition):

Chen, Han-Tong. “Role of serotonin and dopamine in gonadotropin release.” 1979. Doctoral Dissertation, Michigan State University. Accessed January 18, 2021. http://etd.lib.msu.edu/islandora/object/etd:42138.

MLA Handbook (7^th Edition):

Chen, Han-Tong. “Role of serotonin and dopamine in gonadotropin release.” 1979. Web. 18 Jan 2021.

Vancouver:

Chen H. Role of serotonin and dopamine in gonadotropin release. [Internet] [Doctoral dissertation]. Michigan State University; 1979. [cited 2021 Jan 18]. Available from: http://etd.lib.msu.edu/islandora/object/etd:42138.

Council of Science Editors:

Chen H. Role of serotonin and dopamine in gonadotropin release. [Doctoral Dissertation]. Michigan State University; 1979. Available from: http://etd.lib.msu.edu/islandora/object/etd:42138

Michigan State University

22. Zinn, Steven Andrew. Effects of photoperiod on the hypothalamus and on lactotropes in the anterior pituitary gland of Holstein bull calves.

Degree: PhD, Department of Animal Science, 1989, Michigan State University

URL: http://etd.lib.msu.edu/islandora/object/etd:20418

Subjects/Keywords: Photoperiodism; Light – Physiological effect; Hypothalamus; Prolactin; Pituitary gland; Calves

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Zinn, S. A. (1989). Effects of photoperiod on the hypothalamus and on lactotropes in the anterior pituitary gland of Holstein bull calves. (Doctoral Dissertation). Michigan State University. Retrieved from http://etd.lib.msu.edu/islandora/object/etd:20418

Chicago Manual of Style (16^th Edition):

Zinn, Steven Andrew. “Effects of photoperiod on the hypothalamus and on lactotropes in the anterior pituitary gland of Holstein bull calves.” 1989. Doctoral Dissertation, Michigan State University. Accessed January 18, 2021. http://etd.lib.msu.edu/islandora/object/etd:20418.

MLA Handbook (7^th Edition):

Zinn, Steven Andrew. “Effects of photoperiod on the hypothalamus and on lactotropes in the anterior pituitary gland of Holstein bull calves.” 1989. Web. 18 Jan 2021.

Vancouver:

Zinn SA. Effects of photoperiod on the hypothalamus and on lactotropes in the anterior pituitary gland of Holstein bull calves. [Internet] [Doctoral dissertation]. Michigan State University; 1989. [cited 2021 Jan 18]. Available from: http://etd.lib.msu.edu/islandora/object/etd:20418.

Council of Science Editors:

Zinn SA. Effects of photoperiod on the hypothalamus and on lactotropes in the anterior pituitary gland of Holstein bull calves. [Doctoral Dissertation]. Michigan State University; 1989. Available from: http://etd.lib.msu.edu/islandora/object/etd:20418

University of Hong Kong

23. Cheung, Chung-yan. Effects of endocrine manipulation on the peptide levels and the gene expression of {221}-endorphin, met-enkephalin, somatostatin, substanceP and cholecystokinin in the rat hypothalamus and pituitary.

Degree: 1998, University of Hong Kong

URL: http://hdl.handle.net/10722/33964

Subjects/Keywords: Cholecystokinin.; Endorphins.; Pituitary gland.; Rats - Genetics.; Hypothalamus.; Somatostatin.; Enkephalins.

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Cheung, C. (1998). Effects of endocrine manipulation on the peptide levels and the gene expression of {221}-endorphin, met-enkephalin, somatostatin, substanceP and cholecystokinin in the rat hypothalamus and pituitary. (Thesis). University of Hong Kong. Retrieved from http://hdl.handle.net/10722/33964

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Cheung, Chung-yan. “Effects of endocrine manipulation on the peptide levels and the gene expression of {221}-endorphin, met-enkephalin, somatostatin, substanceP and cholecystokinin in the rat hypothalamus and pituitary.” 1998. Thesis, University of Hong Kong. Accessed January 18, 2021. http://hdl.handle.net/10722/33964.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Cheung, Chung-yan. “Effects of endocrine manipulation on the peptide levels and the gene expression of {221}-endorphin, met-enkephalin, somatostatin, substanceP and cholecystokinin in the rat hypothalamus and pituitary.” 1998. Web. 18 Jan 2021.

Vancouver:

Cheung C. Effects of endocrine manipulation on the peptide levels and the gene expression of {221}-endorphin, met-enkephalin, somatostatin, substanceP and cholecystokinin in the rat hypothalamus and pituitary. [Internet] [Thesis]. University of Hong Kong; 1998. [cited 2021 Jan 18]. Available from: http://hdl.handle.net/10722/33964.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Cheung C. Effects of endocrine manipulation on the peptide levels and the gene expression of {221}-endorphin, met-enkephalin, somatostatin, substanceP and cholecystokinin in the rat hypothalamus and pituitary. [Thesis]. University of Hong Kong; 1998. Available from: http://hdl.handle.net/10722/33964

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

24. Λεκκάκου, Λεώνη. Καθορισμός της φυσιολογικής απάντησης του άξονα υποθάλαμος-υπόφυση-επινεφρίδια σε ηλικιωμένους άντρες και γυναίκες, άνω των 65 ετών μετά από ACTH-test.

Degree: 2013, National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ)

URL: http://hdl.handle.net/10442/hedi/39828

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Aim: The aim of this present study is to evaluate the response of hypothalamo-pituitaryadrenal axis to a pharmacological challenge with 1 μg ACTH in elderly… (more)

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Aim: The aim of this present study is to evaluate the response of hypothalamo-pituitaryadrenal axis to a pharmacological challenge with 1 μg ACTH in elderly men and women. Patients and methods: Sixty-one individuals aged from 20-92 years, without history of any acute, chronic disease, or endocrine disorder, were included in the study. The subjects were divided into two groups. The first group consisted of 40 elderly individuals (age > 65 years), 20 men and twenty women with mean age 79.00 ± 6.7 years and BMI 23.7 ± 1.07 kg/m² (mean ± SD). The second group (control group) consisted of 21 younger individuals, 8 men and 13 women with mean age 43.5 ± 10.5 years and BMI 28.6 ± 2.1 kg/m². The subjects underwent a pharmacological stimulation test with intravenous ACTH. Blood samples were obtained at baseline before the administration of ACTH for the determination of basal cortisol and hormones levels and at 30 and 60 minutes post ACTH challenge for the determination of the cortisol response levels. Results: Significant lower values in PRL, IGF-1, DHEAS and T3 were detected in older subjects compared to the young age group. No differences were observed between the groups of older and younger individuals in baseline plasma cortisol and mean cortisol responses at 30 and 60 minutes post challenge. In the elderly subjects statistically lower cortisol responses were noted in males compared to females at 30min and at 60min after 1μg ACTH challenge. No differences were noted in the percentage of subjects with cortisol levels near baseline at 60 minutes. Conclusion: The control of hypothalamo-pituitary-adrenal axis after a stress stimulus is well maintained healthy elderly individuals. Furthermore, a gender effect in the response of cortisol to 1μg ACTH stimulation in the elderly. Elderly men demonstrate a decreased responsiveness compared to women in the same age range.

Σκοπός. Ο στόχος ήταν να ελέγξουμε την απάντηση του άξονα υποθάλαμος-υπόφυση-επινεφρίδια σε ηλικιωμένους άντρες και γυναίκες άνω των 65 ετών χρησιμοποιώντας μια δυναμική δοκιμασία διέγερσης με 1 μg ACTH. Υλικά και μέθοδος. Μελετήθηκαν συνολικά 61 άτομα, ηλικίας 20-92 ετών χωρίς ιστορικό οξείας, χρόνιας νόσου ή ενδοκρινικών διαταραχών. Τα άτομα χωρίστηκαν σε δύο ομάδες. Η πρώτη ομάδα περιελάμβανε 40 άτομα με ηλικία μεγαλύτερη των 65 ετών, 20 άνδρες και 20 γυναίκες, μέσης ηλικίας 79.00 ± 6.7 έτη και με δείκτη σωματικής μάζας 23.7 ± 1.07 kg/m², mean ± SD. Η δεύτερη ομάδα (ομάδα ελέγχου) περιελάμβανε 21 νεότερα άτομα, 8 άνδρες και 13 γυναίκες, ηλικίας 43.5 ± 10.5 έτη και με δείκτη μάζας σώματος 28.6 ± 2.1 kg/m². Τα άτομα υποβλήθηκαν σε δυναμική δοκιμασία με χορήγηση 1 μg ACTH ενδοφλεβίως. Έγινε αιμοληψία στο χρόνο μηδέν πριν τη χορήγηση της ACTH για να μετρηθούν τα βασικά επίπεδα ορμονών και της κορτιζόλης, και στα 30 και 60 λεπτά μετά την χορήγηση για τον προσδιορισμό της απάντησης της κορτιζόλης. Αποτελέσματα. Διαπιστώσαμε στατιστικά σημαντική διαφορά στη μέση τιμή της τριιωδοθυρονίνης, της προλακτίνης, της σωματομεδίνης και της θειικής δευδροεπιανδροστερόνης…

Subjects/Keywords: Άξονα υποθάλαμος-υπόφυση-επινεφρίδια; Κορτικοτροπίνη; Κορτιζόλη; Γήρανση; ACTH-τεστ; Cortisol; Aging; ACTH-test; Hypothalamus-pituitary-adrenal axis; Corticotropin

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Λεκκάκου, . �. (2013). Καθορισμός της φυσιολογικής απάντησης του άξονα υποθάλαμος-υπόφυση-επινεφρίδια σε ηλικιωμένους άντρες και γυναίκες, άνω των 65 ετών μετά από ACTH-test. (Thesis). National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ). Retrieved from http://hdl.handle.net/10442/hedi/39828

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Λεκκάκου, Λεώνη. “Καθορισμός της φυσιολογικής απάντησης του άξονα υποθάλαμος-υπόφυση-επινεφρίδια σε ηλικιωμένους άντρες και γυναίκες, άνω των 65 ετών μετά από ACTH-test.” 2013. Thesis, National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ). Accessed January 18, 2021. http://hdl.handle.net/10442/hedi/39828.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Λεκκάκου, Λεώνη. “Καθορισμός της φυσιολογικής απάντησης του άξονα υποθάλαμος-υπόφυση-επινεφρίδια σε ηλικιωμένους άντρες και γυναίκες, άνω των 65 ετών μετά από ACTH-test.” 2013. Web. 18 Jan 2021.

Vancouver:

Λεκκάκου �. Καθορισμός της φυσιολογικής απάντησης του άξονα υποθάλαμος-υπόφυση-επινεφρίδια σε ηλικιωμένους άντρες και γυναίκες, άνω των 65 ετών μετά από ACTH-test. [Internet] [Thesis]. National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ); 2013. [cited 2021 Jan 18]. Available from: http://hdl.handle.net/10442/hedi/39828.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Λεκκάκου �. Καθορισμός της φυσιολογικής απάντησης του άξονα υποθάλαμος-υπόφυση-επινεφρίδια σε ηλικιωμένους άντρες και γυναίκες, άνω των 65 ετών μετά από ACTH-test. [Thesis]. National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ); 2013. Available from: http://hdl.handle.net/10442/hedi/39828

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

25. Tournikioti, Kalliopi. Συσχέτιση νευρο-ψυχολογικών δεδομένων με ευρήματα από ενδοκρινολογικές και ψυχομετρικές δοκιμασίες στη διπολική συναισθηματική διαταραχή.

Degree: 2014, National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ)

URL: http://hdl.handle.net/10442/hedi/40253

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BackgroundBipolar disorder is associated with neurocognitive impairment but the aetiology of such impairment remains largely unknown. The present study aimed to investigate the performance of… (more)

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BackgroundBipolar disorder is associated with neurocognitive impairment but the aetiology of such impairment remains largely unknown. The present study aimed to investigate the performance of bipolar patients on various cognitive tasks within the framework of the Hypothalamus-Pituitary-Adrenal (HPA) axis hyperactivity model. Moreover, the associations between domains of neuropsychological functioning and various clinical characteristics were explored.MethodsSixty Bipolar-I patients were included in the study. All patients were assessed by CANTAB tasks targeting attention, visual memory and executive function. Affective symptoms as well as global functioning were evaluated via the Hamilton Depression Rating Scale (HAMD), Young Mania Rating Scale (YMRS) and Global Assessment of Functioning (GAF). Furthermore, basal cortisol levels as well as cortisol levels following the dexamethasone suppression test (DST) were determined for all patients.ResultsLevels of basal cortisol were negatively associated with performance in visuo-spatial associative learning/memory. Such association was independent of current psychopathology. On the contrary, post-dexamethasone cortisol was not correlated with neuropsychological functioning. Duration of illness (corrected for age and gender) showed a significant negative correlation with visuo-spatial associative learning/memory whereas it showed a positive association with inhibitory control. A higher number of prior manic episodes and admissions was correlated with decreased attentional set shifting. Furthermore, GAF scores were negatively correlated with errors in the inhibitory control task. As to the effect of current symptoms, manic symptoms showed a negative association with performance in attentional set shifting. On the contrary, HAM-D scores were not correlated with neuropsychological functioning.ConclusionThe results of the present study suggest that among HPA-related factors, basal cortisol is associated with neuropsychological functioning and specifically with performance in visuo-spatial associative learning/memory. They also provide further evidence that indices of illness severity and chronicity, such as duration of illness, number of prior manic episodes and global functioning, are correlated with worse neurocognitive performance. As to the effect of current psychopathology, the severity of manic symptomatology was associated with decreased ability in attentional set shifting whereas depressive symptoms were not correlated with neuropsychological functioning. Cognitive deficits affect a large proportion of bipolar patients leading frequently to considerable psychosocial and occupational dysfunction. The role of HPA axis on cognitive function remains controversial. However, the identification of factors affecting neurocognitive functioning, such as cortisol levels and number of manic episodes, may contribute to the implementation of more appropriate prevention and treatment strategies.

Εισαγωγή- ΣκοπόςΗ Διπολική Συναισθηματική Διαταραχή συνδέεται σε πολλές περιπτώσεις με…

Subjects/Keywords: Διπολική διαταραχή; Άξονας υποθάλαμος-υπόφυση-επινεφρίδια; Νοητική λειτουργικότητα; Bipolar disorder; Hypothalamus-pituitary-adrenal axis; Cognitive function

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Tournikioti, K. (2014). Συσχέτιση νευρο-ψυχολογικών δεδομένων με ευρήματα από ενδοκρινολογικές και ψυχομετρικές δοκιμασίες στη διπολική συναισθηματική διαταραχή. (Thesis). National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ). Retrieved from http://hdl.handle.net/10442/hedi/40253

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Tournikioti, Kalliopi. “Συσχέτιση νευρο-ψυχολογικών δεδομένων με ευρήματα από ενδοκρινολογικές και ψυχομετρικές δοκιμασίες στη διπολική συναισθηματική διαταραχή.” 2014. Thesis, National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ). Accessed January 18, 2021. http://hdl.handle.net/10442/hedi/40253.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Tournikioti, Kalliopi. “Συσχέτιση νευρο-ψυχολογικών δεδομένων με ευρήματα από ενδοκρινολογικές και ψυχομετρικές δοκιμασίες στη διπολική συναισθηματική διαταραχή.” 2014. Web. 18 Jan 2021.

Vancouver:

Tournikioti K. Συσχέτιση νευρο-ψυχολογικών δεδομένων με ευρήματα από ενδοκρινολογικές και ψυχομετρικές δοκιμασίες στη διπολική συναισθηματική διαταραχή. [Internet] [Thesis]. National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ); 2014. [cited 2021 Jan 18]. Available from: http://hdl.handle.net/10442/hedi/40253.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Tournikioti K. Συσχέτιση νευρο-ψυχολογικών δεδομένων με ευρήματα από ενδοκρινολογικές και ψυχομετρικές δοκιμασίες στη διπολική συναισθηματική διαταραχή. [Thesis]. National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ); 2014. Available from: http://hdl.handle.net/10442/hedi/40253

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

26. Geronikolou, Styliani. Μελέτη επίδρασης συνδυασμένων ηλεκτρομαγνητικών πεδίων σε υγιή ελληνικό παιδικό πληθυσμό ηλικίας 11-14 ετών.

Degree: 2016, National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ)

URL: http://hdl.handle.net/10442/hedi/37278

► Aim: To study the potential neurohormonal and inflammatory mechanisms involved in the response of the hypothalamus-pituitary-adrenal axis in children and adolescents of 11-14 years to… (more)

▼ Aim: To study the potential neurohormonal and inflammatory mechanisms involved in the response of the hypothalamus-pituitary-adrenal axis in children and adolescents of 11-14 years to mobile phone call.Material-Methods: 353 questionnaires have been collected so as to describe the pupils of 11-14 years daily exposure to the cellular phone. Their parents answered also to a short questionnaire. 48 volunteers 11-14 year have been divided in two groups have been successively exposed to Trier Social Stress Test and to a mobile phone call. One group (Ι) of 28 volunteers had a 5 min talk to the mobile phone.The other group (ΙΙ) involved 20 volunteers that talked to the phone for 3 min, while only 5 min interfered between the two stressors. The participants’ health status was confirmed by a careful clinical examination (including weight, height,) and personal history data collection including intrauterine life events. Venous blood sampling was then undertaken after an overnight fasting at 8.00 am for tri-iodothyronine (T3), thyroxin (T4), thyroid stimulating hormone (TSH), insulin and glucose determination. The participants were kept in supine position during the whole experiment whereas recordings for heart rate variability were also conducted. Salivary cortisol samples were collected in all participants (valid biomarker of HPA response) in baseline. Furthermore, in group (I) in 10 and 20 min after each stimulation, whereas in group (II) upon completion of each stimulation. Autonomic nervous system recordings and heart rate variability components identification in each part of the experiment was also calculated. Results: Salivary cortisol levels varied insignificantly (p>0.05) upon completion of each stimulation (group II) whereas varied significantly after each stimulation (group I). Baseline hsCRP was correlated both to salivary cortisol levels during mental stress and mean RR intervals after mobile phone call. Baseline blood cortisol was correlated to salivary cortisol levels during mobile phone call. Similarly, baseline thyroid hormones levels predicted salivary cortisol 10 and 20 min after the call in occasional users (Group A) (p<0.05). Mean RR was found decreased during a five minutes call (Group I). The finding remained significant 20 minutes later. The two groups (I and II) differ in the calling duration. It seems that if the call lasts more than 3 minutes respectively a subtle response of the autonomic system arises. However, the system seems to counter balance the perturbation as the LF/HF ratio does not change. Yet, the sympathovagal balance as expressed by LF/HF ratio does not alter significantly. No correlation was observed between baseline ACTH, insulin, glucose levels and salivary cortisol levels of all samples. No alteration was also detected in group (I)for any of the questioned variables as well. Baseline thyroid hormones levels seem to predict the cortisol response to mental stress mainly in group A, while HOMA had no impact on salivary cortisol response at any phase of the test, in either…

Subjects/Keywords: Άξονας υποθάλαμος-υπόφυση-θυρεοειδής; Άξονας υποθάλαμος - υπόφυση - επινεφρίδια; Αυτόνομο νευρικό σύστημα; Κινητό τηλέφωνο; Παιδιά και έφηβοι; Μετα-ανάλυση; Αρνητική παλίνδρομη ρύθμιση; Hypothalamus pituitary thyroid axis; Hypothalamus pituitary adrenal axis; Autonomic nervous system; Cell phone; Children and adolescents; Meta-analysis; Negative feedback loop

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Geronikolou, S. (2016). Μελέτη επίδρασης συνδυασμένων ηλεκτρομαγνητικών πεδίων σε υγιή ελληνικό παιδικό πληθυσμό ηλικίας 11-14 ετών. (Thesis). National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ). Retrieved from http://hdl.handle.net/10442/hedi/37278

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Geronikolou, Styliani. “Μελέτη επίδρασης συνδυασμένων ηλεκτρομαγνητικών πεδίων σε υγιή ελληνικό παιδικό πληθυσμό ηλικίας 11-14 ετών.” 2016. Thesis, National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ). Accessed January 18, 2021. http://hdl.handle.net/10442/hedi/37278.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Geronikolou, Styliani. “Μελέτη επίδρασης συνδυασμένων ηλεκτρομαγνητικών πεδίων σε υγιή ελληνικό παιδικό πληθυσμό ηλικίας 11-14 ετών.” 2016. Web. 18 Jan 2021.

Vancouver:

Geronikolou S. Μελέτη επίδρασης συνδυασμένων ηλεκτρομαγνητικών πεδίων σε υγιή ελληνικό παιδικό πληθυσμό ηλικίας 11-14 ετών. [Internet] [Thesis]. National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ); 2016. [cited 2021 Jan 18]. Available from: http://hdl.handle.net/10442/hedi/37278.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Geronikolou S. Μελέτη επίδρασης συνδυασμένων ηλεκτρομαγνητικών πεδίων σε υγιή ελληνικό παιδικό πληθυσμό ηλικίας 11-14 ετών. [Thesis]. National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ); 2016. Available from: http://hdl.handle.net/10442/hedi/37278

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

27. Mazer, Angela Kaline. Diagnóstico diferencial entre transtorno afetivo bipolar e transtorno de personalidade borderline fundamentado na história de estresse precoce e em avaliação psiconeuroendócrina.

Degree: Mestrado, Saúde Mental, 2013, University of São Paulo

URL: http://www.teses.usp.br/teses/disponiveis/17/17148/tde-20052014-085440/ ;

► Introdução: O Transtorno Afetivo Bipolar (TAB) e o Transtorno de Personalidade Borderline (TPB) apresentam características clínicas em comum que frequentemente tornam difícil seu diagnóstico diferencial,… (more)

▼ Introdução: O Transtorno Afetivo Bipolar (TAB) e o Transtorno de Personalidade Borderline (TPB) apresentam características clínicas em comum que frequentemente tornam difícil seu diagnóstico diferencial, podendo implicar em indicações terapêuticas inadequadas. Assim, é importante ampliar o conhecimento diagnóstico sobre esses transtornos mentais buscando identificar marcadores que auxiliem sua diferenciação. A história de estresse precoce, associada à vulnerabilidade individual no desenvolvimento de transtornos mentais relatada na literatura, pode representar um fator de diferenciação entre TAB e TPB, assim como sua associação com manifestações clínicas e respostas neuroendócrinas específicas a cada um desses diagnósticos. Objetivo: Avaliação e comparação de pacientes com diagnóstico de TAB e TPB buscando indicadores de seu diagnóstico diferencial, relacionados a fatores associados a sua sintomatologia, etiopatogênese e marcadores neuroendócrinos. Metodologia: A amostra do estudo foi composta por 51 mulheres, distribuídas em 3 grupos constituídos por pacientes com diagnóstico clínico de TAB (n=16) e TPB (n=20), e controles saudáveis (n=15). Para sua avaliação, foram utilizados instrumentos para confirmação diagnóstica e entrevista semiestruturada para delineamento do perfil sócio-demográfico e clínico. A gravidade da sintomatologia psiquiátrica foi avaliada através dos instrumentos de Beck para avaliação de ansiedade, depressão, desesperança e ideação suicida, além de escalas de avaliação de sintomas maníacos e impulsividade. A história de estresse precoce foi investigada pelo Questionário de Traumas na Infância (CTQ), e classificada segundo os subtipos abuso emocional, abuso físico, abuso sexual, negligência emocional e negligência física. O funcionamento do eixo hipotálamo- hipófise-adrenal (HHA) foi avaliado pela dosagem de cortisol basal plasmático. Os resultados das avaliações foram analisados em um segundo momento de acordo com a presença ou ausência de estresse precoce. Resultados: A amostra de pacientes com diagnósticos de TAB e TPB analisadas apresentaram diferenças significativas em relação à idade e tempo de tratamento, maiores no grupo TAB. A análise da sintomatologia psiquiátrica indica maior gravidade de ansiedade, impulsividade, depressão, desesperança e ideação suicida no grupo TPB. A história de estresse precoce foi identificada como mais prevalente e significativamente mais grave nas pacientes do que em controles saudáveis, nos escores de CTQ total, abuso emocional, negligência emocional e negligência física, que também diferenciaram os grupos diagnósticos, sendo maiores no TPB comparado ao TAB. A partir da presença do estresse precoce em níveis de moderado a extremo, o subtipo negligência física diferenciou significativamente os diagnósticos, indicando ser mais grave quando associado ao TPB. A avaliação endócrina indicou diferenças entre os diagnósticos TAB e TPB em relação aos controles saudáveis, com níveis mais baixos de cortisol apresentados pelas pacientes. A presença de estresse precoce em… Advisors/Committee Members: Juruena, Mário Francisco Pereira.

Subjects/Keywords: Axis Hypothalamus-Pituitary-Adrenal; Bipolar Disorder; Borderline Personality Disorder; Cortisol; Cortisol; Early Stress; Eixo Hipotálamo-Hipófise- Adrenal; Estresse Precoce; Transtorno Afetivo Bipolar; Transtorno de Personalidade Borderline

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Mazer, A. K. (2013). Diagnóstico diferencial entre transtorno afetivo bipolar e transtorno de personalidade borderline fundamentado na história de estresse precoce e em avaliação psiconeuroendócrina. (Masters Thesis). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/17/17148/tde-20052014-085440/ ;

Chicago Manual of Style (16^th Edition):

Mazer, Angela Kaline. “Diagnóstico diferencial entre transtorno afetivo bipolar e transtorno de personalidade borderline fundamentado na história de estresse precoce e em avaliação psiconeuroendócrina.” 2013. Masters Thesis, University of São Paulo. Accessed January 18, 2021. http://www.teses.usp.br/teses/disponiveis/17/17148/tde-20052014-085440/ ;.

MLA Handbook (7^th Edition):

Mazer, Angela Kaline. “Diagnóstico diferencial entre transtorno afetivo bipolar e transtorno de personalidade borderline fundamentado na história de estresse precoce e em avaliação psiconeuroendócrina.” 2013. Web. 18 Jan 2021.

Vancouver:

Mazer AK. Diagnóstico diferencial entre transtorno afetivo bipolar e transtorno de personalidade borderline fundamentado na história de estresse precoce e em avaliação psiconeuroendócrina. [Internet] [Masters thesis]. University of São Paulo; 2013. [cited 2021 Jan 18]. Available from: http://www.teses.usp.br/teses/disponiveis/17/17148/tde-20052014-085440/ ;.

Council of Science Editors:

Mazer AK. Diagnóstico diferencial entre transtorno afetivo bipolar e transtorno de personalidade borderline fundamentado na história de estresse precoce e em avaliação psiconeuroendócrina. [Masters Thesis]. University of São Paulo; 2013. Available from: http://www.teses.usp.br/teses/disponiveis/17/17148/tde-20052014-085440/ ;

28. Honji, Renato Massaaki. Controle do eixo hipotálamo-hipófise-gônadas do surubim do Paraíba Steindachneridion parahybae (Siluriformes:Pimelodidae) em relação ao ciclo reprodutivo e à reprodução induzida em cativeiro.

Degree: PhD, Fisiologia Geral, 2011, University of São Paulo

URL: http://www.teses.usp.br/teses/disponiveis/41/41135/tde-18012012-112928/ ;

► Steindachneridion parahybae (Siluriformes) é um bagre de água doce, endêmico da Bacia do Rio Paraíba do Sul (Brasil), e seriamente ameaçado de extinção. Fêmeas de… (more)

▼ Steindachneridion parahybae (Siluriformes) é um bagre de água doce, endêmico da Bacia do Rio Paraíba do Sul (Brasil), e seriamente ameaçado de extinção. Fêmeas de S. parahybae quando criadas em cativeiro apresentam uma falha na maturação final, ovulação e desova. Este trabalho teve como objetivo analisar o eixo hipotálamo-hipófise-gônadas, responsável pelo controle neuroendócrino da reprodução de forma a aumentar o conhecimento deste sistema em animais de cativeiro. Fêmeas adultas foram amostradas mensalmente (exceto nos meses de inverno) entre janeiro/2008 e março/2009 na piscicultura da Companhia Energética de São Paulo. As análises macroscópicas e microscópicas dos ovários permitiram classificar o desenvolvimento ovariano em três estádios de maturação: pré-vitelogênico (crescimento primário), vitelogênico (crescimento secundário) e regressão; e cinco fases de desenvolvimento oocitário foram identificadas: oogônia, oócito perinucleolar, oócito alvéolo cortical, oócito vitelogênico e oócito atrésico. Após a indução à reprodução artificial, a maturação final foi alcançada e os folículos pós-ovulatórios foram identificados. Em S. parahybae, o período reprodutivo foi evidente entre novembro e fevereiro e o desenvolvimento oocitário foi do tipo sincrônio em grupo, sugerindo-se que esta espécie apresenta múltiplas desovas durante este período. Os perfis plasmáticos de 17Beta-estradiol (E2) e testosterona (T) foram fundamentais no desenvolvimento oocitário, e a produção destes esteróides sexuais parece não ser afetada no bloqueio da reprodução em cativeiro. Entretanto, as concentrações de 17Alfa-hidroxiprogesterona (17Alfa-OHP), durante o ciclo reprodutivo e após a indução à reprodução, sugerem que a falha reprodutiva de S. parahybae esteja relacionada com uma disfunção nos progestágenos, principalmente na conversão do 17Alfa-OHP em 17alfa,20Beta-dihydroxy-4-pregnen-3-one (Maturation-Inducing Steroid, MIS), este último considerado como hormônio da maturação final e ovulação em teleósteos. O andrógeno 11-cetotestosterona (11-KT) apresentou maior concentração no estádio vitelogênico e nas fêmeas induzidas à reprodução, sugerindo um envolvimento deste andrógeno na reprodução de S. parahybae. No entanto, o sítio de síntese e ação, assim como, as possíveis funções de 11-KT ainda permanecem pouco investigadas em fêmeas. No sistema encefálico foram caracterizadas duas formas do hormônio-liberador de gonadotropinas (GnRH), catfish GnRH (cfGnRH) e chicken-II GnRH (cGnRH-II). cfGnRH foi identificado em toda região ventral do telencéfalo e em várias regiões ventrais do diencéfalo, e o cGnRH-II foi observado na região do tegumento do cérebro médio, próximo ao terceiro ventrículo. O cfGnRH está intimamente relacionado com a modulação da atividade da hipófise, e ao contrario, o cGnRH-II (que não inerva a hipófise), provavelmente está relacionado com a neuromodulação e/ou comportamento reprodutivo em S. parahybae. A hipófise é composta pela neuro-hipófise (NH) e adeno-hipófise (ADH), sendo que, a ADH é subdividida em: \"rostral pars… Advisors/Committee Members: Moreira, Renata Guimarães.

Subjects/Keywords: Controle endócrino da reprodução; Desenvolvimento oocitário; Eixo hipotálamo-hipófise-gônadas; Endocrine control of reproduction; Esteróides sexuais; Gonadotropinas; Hormônio liberador de gonadotropinas; Hypothalamus-pituitary; Reprodução induzida; Steindachneridion parahybae; Steindachneridion parahybae

Record Details Similar Records Cite « Share

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Honji, R. M. (2011). Controle do eixo hipotálamo-hipófise-gônadas do surubim do Paraíba Steindachneridion parahybae (Siluriformes:Pimelodidae) em relação ao ciclo reprodutivo e à reprodução induzida em cativeiro. (Doctoral Dissertation). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/41/41135/tde-18012012-112928/ ;

Chicago Manual of Style (16^th Edition):

Honji, Renato Massaaki. “Controle do eixo hipotálamo-hipófise-gônadas do surubim do Paraíba Steindachneridion parahybae (Siluriformes:Pimelodidae) em relação ao ciclo reprodutivo e à reprodução induzida em cativeiro.” 2011. Doctoral Dissertation, University of São Paulo. Accessed January 18, 2021. http://www.teses.usp.br/teses/disponiveis/41/41135/tde-18012012-112928/ ;.

MLA Handbook (7^th Edition):

Honji, Renato Massaaki. “Controle do eixo hipotálamo-hipófise-gônadas do surubim do Paraíba Steindachneridion parahybae (Siluriformes:Pimelodidae) em relação ao ciclo reprodutivo e à reprodução induzida em cativeiro.” 2011. Web. 18 Jan 2021.

Vancouver:

Honji RM. Controle do eixo hipotálamo-hipófise-gônadas do surubim do Paraíba Steindachneridion parahybae (Siluriformes:Pimelodidae) em relação ao ciclo reprodutivo e à reprodução induzida em cativeiro. [Internet] [Doctoral dissertation]. University of São Paulo; 2011. [cited 2021 Jan 18]. Available from: http://www.teses.usp.br/teses/disponiveis/41/41135/tde-18012012-112928/ ;.

Council of Science Editors:

Honji RM. Controle do eixo hipotálamo-hipófise-gônadas do surubim do Paraíba Steindachneridion parahybae (Siluriformes:Pimelodidae) em relação ao ciclo reprodutivo e à reprodução induzida em cativeiro. [Doctoral Dissertation]. University of São Paulo; 2011. Available from: http://www.teses.usp.br/teses/disponiveis/41/41135/tde-18012012-112928/ ;

29. Schür, RR. In the aftermath of trauma : Marks of stress-related psychopathology.

Degree: 2017, University Utrecht

URL: http://dspace.library.uu.nl/handle/1874/352676 ; URN:NBN:NL:UI:10-1874-352676 ; urn:isbn:978-94-6295-692-6 ; URN:NBN:NL:UI:10-1874-352676 ; http://dspace.library.uu.nl/handle/1874/352676

► In this thesis we investigated (traumatic) stress and psychopathology with a focus on the potential roles of the hypothalamus-pituitary-adrenal (HPA) axis, the GABA system, their… (more)

▼ In this thesis we investigated (traumatic) stress and psychopathology with a focus on the potential roles of the hypothalamus-pituitary-adrenal (HPA) axis, the GABA system, their association, and the general genetic background of major depressive disorder (MDD) and posttraumatic stress disorder (PTSD). We first reviewed the evidence on the cortisol response to psychosocial stress across psychiatric disorders and found that sex and symptomatic state are crucial factors to consider when comparing patients with healthy controls. Whereas women with MDD or an anxiety disorder showed blunting of the cortisol stress response, men with MDD or social anxiety disorder (SAD; the most commonly studied anxiety disorder) showed an increased cortisol stress response. These aberrations were absent (in men) or attenuated (in women) in individuals remitted from MDD compared with controls. Furthermore, we investigated changes in glucocorticoid receptor (GR) exon 1F methylation over time in a military cohort deployed to Afghanistan. We showed that trauma exposure during deployment was associated with an increase in GR-1F methylation six months after deployment and that specifically increases at functionally relevant sites were associated with the development of post-deployment psychopathology. With regard to the GABA system, we evaluated the literature on in vivo brain GABA levels (as measured with proton magnetic resonance spectroscopy (1H-MRS)) across psychiatric disorders and found lower GABA levels in patients with MDD compared with controls, but not in patients remitted from MDD. Moreover, convincingly lower brain GABA levels were observed in patients with autism spectrum disorder and a trend level GABA decrease was seen in patients with schizophrenia compared with healthy individuals. Subsequently, we examined change in plasma GABA levels in relation to psychopathology and trauma exposure during deployment in a large military cohort. A rise in plasma GABA levels over time was associated with the development of psychopathology (especially depressive symptoms), but not with trauma exposure. As GABA levels rose after the development of psychopathology symptoms, it may serve as a compensatory mechanism for these symptoms. To investigate the link between the GABA (and glutamate) system and the HPA axis we used 1H-MRS to investigate changes in medial prefrontal GABA and glutamate levels in response to a psychosocial stress test and in relation to salivary cortisol levels over time in healthy individuals. We did not find evidence for an effect of stress on brain GABA or glutamate levels 30 minutes after stress onset, nor did we observe an association between the cortisol stress response and GABA or glutamate levels. Finally, we calculated polygenic risk scores based on the largest genome-wide association studies so far for MDD and PTSD and found no main effect or interaction of these score with trauma exposure during military deployment on the development of PTSD and depressive symptoms at five time points up to five years… Advisors/Committee Members: Kahn, René, Joëls, Marian, Vinkers, Christiaan, Boks, Marco.

Subjects/Keywords: Trauma; Stress; GABA; Hypothalamus-pituitary-adrenal-axis; cortisol; psychopathology; depression; PTSD; deployment; longitudinal

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Schür, R. (2017). In the aftermath of trauma : Marks of stress-related psychopathology. (Doctoral Dissertation). University Utrecht. Retrieved from http://dspace.library.uu.nl/handle/1874/352676 ; URN:NBN:NL:UI:10-1874-352676 ; urn:isbn:978-94-6295-692-6 ; URN:NBN:NL:UI:10-1874-352676 ; http://dspace.library.uu.nl/handle/1874/352676

Chicago Manual of Style (16^th Edition):

Schür, RR. “In the aftermath of trauma : Marks of stress-related psychopathology.” 2017. Doctoral Dissertation, University Utrecht. Accessed January 18, 2021. http://dspace.library.uu.nl/handle/1874/352676 ; URN:NBN:NL:UI:10-1874-352676 ; urn:isbn:978-94-6295-692-6 ; URN:NBN:NL:UI:10-1874-352676 ; http://dspace.library.uu.nl/handle/1874/352676.

MLA Handbook (7^th Edition):

Schür, RR. “In the aftermath of trauma : Marks of stress-related psychopathology.” 2017. Web. 18 Jan 2021.

Vancouver:

Schür R. In the aftermath of trauma : Marks of stress-related psychopathology. [Internet] [Doctoral dissertation]. University Utrecht; 2017. [cited 2021 Jan 18]. Available from: http://dspace.library.uu.nl/handle/1874/352676 ; URN:NBN:NL:UI:10-1874-352676 ; urn:isbn:978-94-6295-692-6 ; URN:NBN:NL:UI:10-1874-352676 ; http://dspace.library.uu.nl/handle/1874/352676.

Council of Science Editors:

Schür R. In the aftermath of trauma : Marks of stress-related psychopathology. [Doctoral Dissertation]. University Utrecht; 2017. Available from: http://dspace.library.uu.nl/handle/1874/352676 ; URN:NBN:NL:UI:10-1874-352676 ; urn:isbn:978-94-6295-692-6 ; URN:NBN:NL:UI:10-1874-352676 ; http://dspace.library.uu.nl/handle/1874/352676

30. Schür, RR. In the aftermath of trauma : Marks of stress-related psychopathology.

Degree: 2017, University Utrecht

URL: https://dspace.library.uu.nl/handle/1874/352676 ; URN:NBN:NL:UI:10-1874-352676 ; urn:isbn:978-94-6295-692-6 ; URN:NBN:NL:UI:10-1874-352676 ; https://dspace.library.uu.nl/handle/1874/352676

► In this thesis we investigated (traumatic) stress and psychopathology with a focus on the potential roles of the hypothalamus-pituitary-adrenal (HPA) axis, the GABA system, their… (more)

▼ In this thesis we investigated (traumatic) stress and psychopathology with a focus on the potential roles of the hypothalamus-pituitary-adrenal (HPA) axis, the GABA system, their association, and the general genetic background of major depressive disorder (MDD) and posttraumatic stress disorder (PTSD). We first reviewed the evidence on the cortisol response to psychosocial stress across psychiatric disorders and found that sex and symptomatic state are crucial factors to consider when comparing patients with healthy controls. Whereas women with MDD or an anxiety disorder showed blunting of the cortisol stress response, men with MDD or social anxiety disorder (SAD; the most commonly studied anxiety disorder) showed an increased cortisol stress response. These aberrations were absent (in men) or attenuated (in women) in individuals remitted from MDD compared with controls. Furthermore, we investigated changes in glucocorticoid receptor (GR) exon 1F methylation over time in a military cohort deployed to Afghanistan. We showed that trauma exposure during deployment was associated with an increase in GR-1F methylation six months after deployment and that specifically increases at functionally relevant sites were associated with the development of post-deployment psychopathology. With regard to the GABA system, we evaluated the literature on in vivo brain GABA levels (as measured with proton magnetic resonance spectroscopy (1H-MRS)) across psychiatric disorders and found lower GABA levels in patients with MDD compared with controls, but not in patients remitted from MDD. Moreover, convincingly lower brain GABA levels were observed in patients with autism spectrum disorder and a trend level GABA decrease was seen in patients with schizophrenia compared with healthy individuals. Subsequently, we examined change in plasma GABA levels in relation to psychopathology and trauma exposure during deployment in a large military cohort. A rise in plasma GABA levels over time was associated with the development of psychopathology (especially depressive symptoms), but not with trauma exposure. As GABA levels rose after the development of psychopathology symptoms, it may serve as a compensatory mechanism for these symptoms. To investigate the link between the GABA (and glutamate) system and the HPA axis we used 1H-MRS to investigate changes in medial prefrontal GABA and glutamate levels in response to a psychosocial stress test and in relation to salivary cortisol levels over time in healthy individuals. We did not find evidence for an effect of stress on brain GABA or glutamate levels 30 minutes after stress onset, nor did we observe an association between the cortisol stress response and GABA or glutamate levels. Finally, we calculated polygenic risk scores based on the largest genome-wide association studies so far for MDD and PTSD and found no main effect or interaction of these score with trauma exposure during military deployment on the development of PTSD and depressive symptoms at five time points up to five years… Advisors/Committee Members: Kahn, René, Joëls, Marian, Vinkers, Christiaan, Boks, Marco.

Subjects/Keywords: Trauma; Stress; GABA; Hypothalamus-pituitary-adrenal-axis; cortisol; psychopathology; depression; PTSD; deployment; longitudinal

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Schür, R. (2017). In the aftermath of trauma : Marks of stress-related psychopathology. (Doctoral Dissertation). University Utrecht. Retrieved from https://dspace.library.uu.nl/handle/1874/352676 ; URN:NBN:NL:UI:10-1874-352676 ; urn:isbn:978-94-6295-692-6 ; URN:NBN:NL:UI:10-1874-352676 ; https://dspace.library.uu.nl/handle/1874/352676

Chicago Manual of Style (16^th Edition):

Schür, RR. “In the aftermath of trauma : Marks of stress-related psychopathology.” 2017. Doctoral Dissertation, University Utrecht. Accessed January 18, 2021. https://dspace.library.uu.nl/handle/1874/352676 ; URN:NBN:NL:UI:10-1874-352676 ; urn:isbn:978-94-6295-692-6 ; URN:NBN:NL:UI:10-1874-352676 ; https://dspace.library.uu.nl/handle/1874/352676.

MLA Handbook (7^th Edition):

Schür, RR. “In the aftermath of trauma : Marks of stress-related psychopathology.” 2017. Web. 18 Jan 2021.

Vancouver:

Schür R. In the aftermath of trauma : Marks of stress-related psychopathology. [Internet] [Doctoral dissertation]. University Utrecht; 2017. [cited 2021 Jan 18]. Available from: https://dspace.library.uu.nl/handle/1874/352676 ; URN:NBN:NL:UI:10-1874-352676 ; urn:isbn:978-94-6295-692-6 ; URN:NBN:NL:UI:10-1874-352676 ; https://dspace.library.uu.nl/handle/1874/352676.

Council of Science Editors:

Schür R. In the aftermath of trauma : Marks of stress-related psychopathology. [Doctoral Dissertation]. University Utrecht; 2017. Available from: https://dspace.library.uu.nl/handle/1874/352676 ; URN:NBN:NL:UI:10-1874-352676 ; urn:isbn:978-94-6295-692-6 ; URN:NBN:NL:UI:10-1874-352676 ; https://dspace.library.uu.nl/handle/1874/352676

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