subject:(Hyperparathyroidism)

Rutgers University

1. Al-Hraishawi, Haidar Khaioon, 1986-. Comparison of metabolic and characteristic features of primary hyperparathyroidism patients with different intact PTH levels.

Degree: MS, Physiology and Integrative Biology, 2016, Rutgers University

URL: https://rucore.libraries.rutgers.edu/rutgers-lib/49903/

► This study is to compare primary hyperparathyroidism (PHPT) patients with different iPTH levels for serum calcium and other laboratory values. In this retrospective study, 212… (more)

▼ This study is to compare primary hyperparathyroidism (PHPT) patients with different iPTH levels for serum calcium and other laboratory values. In this retrospective study, 212 patients who presented at Robert Wood Johnson Hospital were assessed for metabolic and characteristic features of PHPT. Patients were divided into two groups according to their serum intact parathyroid hormone (iPTH) levels. Student t- tests were used to compare the two groups for differences in age, body mass index (BMI), adenoma weight, and laboratory test values which included serum calcium, iPTH, 25OHD, lipid panel, serum creatinine, ALP, and 24 hr. urinary calcium. Pearson`s correlation coefficient was used to assess the relationship. Of the 212 PHPT patients, 100 (17 males and 83 females) were classified as m-iPTH group (iPTH below 140 pg/ml), whereas 112 patients (25 males and 87 females) were classified as h-iPTH group (iPTH above 140 pg/ml). Higher-iPTH patients are younger than m-iPTH patients. No statistic significant differences in BMI, T-cholesterol and TG were found between the m-iPTH and h-iPTH groups. Higher- iPTH patients compared with m- iPTH, had slightly but significantly higher calcium, lower 25OHD, lower HDL, higher ALP, and very close to have higher adenoma weight. Additionally, we found iPTH was positive correlated with serum calcium, adenoma weight, and triglyceride (TG) levels, and negatively correlated with HDL and 25OHD. Intact PTH did not correlate with BMI and T- cholesterol levels. Furthermore, 24 hr. urinary calcium and serum ALP were positively associated with iPTH levels but not significantly (P = 0.08, P = 0.09) respectively. These correlations were independent of serum calcium and 25OHD levels except TG was dependent of reduced 25OHD, while serum ALP was dependent of calcium levels. These findings from our analysis consistent with previous studies suggesting iPTH levels correlated metabolic syndrome. Additionally, our results suggest that h- iPTH patients tend to be younger ones, with lower HDL, lower 25OHD, and higher ALP. While the underline mechanisms for these changes are unclear, we speculate that the elevated iPTH levels might decrease HDL directly or indirectly through increasing insulin resistance by weight gain, and increases ALP through PTH receptors on osteoblasts. This study supported our hypothesis that iPTH levels are an important factor to contribute in the management of PHPT patients. Intact PTH levels, lipid panel, 25OHD, ALP in addition to calcium levels might also need to be considered in the therapeutic decision for PHPT patients. Advisors/Committee Members: Fan, Huizhou (chair), Wang, Xiangbing (internal member), Haimovich, Beatrice (outside member).

Subjects/Keywords: Hyperparathyroidism

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APA (6^th Edition):

Al-Hraishawi, Haidar Khaioon, 1. (2016). Comparison of metabolic and characteristic features of primary hyperparathyroidism patients with different intact PTH levels. (Masters Thesis). Rutgers University. Retrieved from https://rucore.libraries.rutgers.edu/rutgers-lib/49903/

Chicago Manual of Style (16^th Edition):

Al-Hraishawi, Haidar Khaioon, 1986-. “Comparison of metabolic and characteristic features of primary hyperparathyroidism patients with different intact PTH levels.” 2016. Masters Thesis, Rutgers University. Accessed April 12, 2021. https://rucore.libraries.rutgers.edu/rutgers-lib/49903/.

MLA Handbook (7^th Edition):

Al-Hraishawi, Haidar Khaioon, 1986-. “Comparison of metabolic and characteristic features of primary hyperparathyroidism patients with different intact PTH levels.” 2016. Web. 12 Apr 2021.

Vancouver:

Al-Hraishawi, Haidar Khaioon 1. Comparison of metabolic and characteristic features of primary hyperparathyroidism patients with different intact PTH levels. [Internet] [Masters thesis]. Rutgers University; 2016. [cited 2021 Apr 12]. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/49903/.

Council of Science Editors:

Al-Hraishawi, Haidar Khaioon 1. Comparison of metabolic and characteristic features of primary hyperparathyroidism patients with different intact PTH levels. [Masters Thesis]. Rutgers University; 2016. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/49903/

2. Bruining, Hajo. Surgical treatment of hyperparathyroidism : with an analysis of 267 cases.

Degree: 1971, Erasmus University Medical Center

URL: http://hdl.handle.net/1765/26429

► textabstractIt is generally accepted that for autonomous hyperparathyroidism, whether primary or tertiary, surgery is still the only suitable method of treatment available. Analysis of a… (more)

▼ textabstractIt is generally accepted that for autonomous hyperparathyroidism, whether primary or tertiary, surgery is still the only suitable method of treatment available. Analysis of a series of cases treated in t his way over the past twenty years has shown that there are certain problems associated with the treatment of this disease that have not yet been solved. Even experienced surgeons may have difficulty in finding the parathyroid glands when the localization or number is abnormal. The histological differentiation between nodular hyperplastic, and adenomatous parathyroid tissue may be extremely difficult, sometimes even impossible. It is just this difference that might determine the amount of resection and the postoperative course. Furthermore, in some cases it is exceedingly difficult for the surgeon to judge whether a parathyroid is of normal size and has a normal appearance. Lastly, the etiology of primary hyperparathyroidism is still unknown. In the present work the findings in 267 patients treated surgically between 1950 and 1970 are discussed and evaluated in relation to the data in the literature. Special attention is paid to the etiology of the disease, the histological picture, and the surgical technique. The symptomatology, diagnosis, and biochemical changes will only be mentioned briefly, since the problems associated with them are so numerous that they deserve separate treatment. A thesis on these subjects is in preparation in Leiden. Because the prognosis of associated disease, especially the renal, is the more favourable the earlier the diagnosis is made, some principles are given to promote earlier consideration of the diagnosis hyperparathyroidism in cases with few symptoms. The data of 267 patients who underwent an operation between 1950 and 1970 under the probability diagnosis hyperparathyroidism are discussed. These patients were treated in the Leiden University Hospital, the Leiden Diaconess Hospital, or the Rotterdam University Hospital. In 255 of t hese cases the diagnosis was confirmed at surgery and histologically.

Subjects/Keywords: hyperparathyroidism; surgery

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APA (6^th Edition):

Bruining, H. (1971). Surgical treatment of hyperparathyroidism : with an analysis of 267 cases. (Doctoral Dissertation). Erasmus University Medical Center. Retrieved from http://hdl.handle.net/1765/26429

Chicago Manual of Style (16^th Edition):

Bruining, Hajo. “Surgical treatment of hyperparathyroidism : with an analysis of 267 cases.” 1971. Doctoral Dissertation, Erasmus University Medical Center. Accessed April 12, 2021. http://hdl.handle.net/1765/26429.

MLA Handbook (7^th Edition):

Bruining, Hajo. “Surgical treatment of hyperparathyroidism : with an analysis of 267 cases.” 1971. Web. 12 Apr 2021.

Vancouver:

Bruining H. Surgical treatment of hyperparathyroidism : with an analysis of 267 cases. [Internet] [Doctoral dissertation]. Erasmus University Medical Center; 1971. [cited 2021 Apr 12]. Available from: http://hdl.handle.net/1765/26429.

Council of Science Editors:

Bruining H. Surgical treatment of hyperparathyroidism : with an analysis of 267 cases. [Doctoral Dissertation]. Erasmus University Medical Center; 1971. Available from: http://hdl.handle.net/1765/26429

Univerzitet u Beogradu

3. Cvijović, Goran M., 1971-. Sekrecija insulina i insulinska senzitivnost perifernih tkiva pre i nakon radikalnog lečenja primarnog hiperparatireoidizma.

Degree: Medicinski fakultet, 2016, Univerzitet u Beogradu

URL: https://fedorabg.bg.ac.rs/fedora/get/o:12592/bdef:Content/get

►

INTERNA MEDICINA - ENDOKRINOLOGIJA / INTERNAL MEDICINE - ENDOCRINOLOGY

Uvod i cilj: Prethodno je uočeno postojanje insulinske rezistencije i povećana prevalenca oštećene tolerancije na glikozu… (more)

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INTERNA MEDICINA - ENDOKRINOLOGIJA / INTERNAL MEDICINE - ENDOCRINOLOGY

Uvod i cilj: Prethodno je uočeno postojanje insulinske rezistencije i povećana prevalenca oštećene tolerancije na glikozu i tipa 2 dijabetesa kod pacijenata sa primarnim hiperparatireoidizmom. Efekat paratireoidektomije na insulinsku senzitivnost je praćen kontraverznim nalazima u zavisnosti od metode koja je korištena za procenu insulinske senzitivnosti: nije bilo promene kada su korišteni HOMA i QUICKI dok je Minimalnim modelom pokazano značajno poboljšanje insulinske senzitivnosti.Cilj ovog rada je bio da se proceni insulinska senzitivnost pre i nakon paratireoidektomije kod pacijenata sa PHPT putem euglikemijskog hiperinsulinemijskog klampa. Materijal i metode: Kod 44 pacijenta sa PHPT i 11 zdravih kontrola komparabilne starosti i indeksa telesne mase procenjivali smo insulinsku senzitivnost (pomoću tehnike klampa, HOMA IR i ISI indeksa), insulinsku sekreciju (putem površine pod krivom za glikemije i insulinemije tokom OGTTa i izračunavajući akutni insulinski odgovor iz podataka dobijenih IVGTTom), lipidni profil i nivo hsCRP kao marker hronične inflamacije. Rezultati: Pre operacije vrednosti M indeksa i HOMA IR su ukazivale na postojanje insulinske rezistencije kod pacijenata sa PHPT. Nije bilo razlike u M indeksu (3.74±1.89 vs 4.62±2.27, p >0.05), HOMA IR (2.94±1.39 vs. 3.29±0.81, p > 0.05), AUC glikoze (863.0±261.3 vs 842.3±165.5, p>0.05), AUC insulina (7068.7±4159.0 vs 7229.6±2581.7, p>0.05), ISI (4.73±2.77 vs 4.25±2.94, p>0.05) i AIR (47.89±32.05 vs. 38.96±21.20, p>0.05) izmeĎu pacijenata sa PHPT i zdravih kontrola. Došlo je do značajnog poboljšanja insulinske senzitivnosti nakon operacije al ii preoperativna i postoperativna vrednost M indeksa se nisu razlikovale od zdravih kontrola. Nije uočena promena u HOMA IR, AUC za glikozu i insulin ISI i AIR, lipidima i hsCRP nakon operacije. Zaključak: Dobili smo značajno poboljšanje insulinske senzitivnosti nakon paratireoidektomije kod pacijenata sa PHPT koristeći klamp tehniku. Postoperativno nije do došlo do značajne promene u drugim pokazateljima insulinske senzitivnosti, paramtrima insulinske sekrecije, lipidima i hsCRP.

Advisors/Committee Members: Micić, Dragan, 1950-.

Subjects/Keywords: primary hyperparathyroidism; insulin sensitivity; insulin secretion

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Cvijović, Goran M., 1. (2016). Sekrecija insulina i insulinska senzitivnost perifernih tkiva pre i nakon radikalnog lečenja primarnog hiperparatireoidizma. (Thesis). Univerzitet u Beogradu. Retrieved from https://fedorabg.bg.ac.rs/fedora/get/o:12592/bdef:Content/get

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Cvijović, Goran M., 1971-. “Sekrecija insulina i insulinska senzitivnost perifernih tkiva pre i nakon radikalnog lečenja primarnog hiperparatireoidizma.” 2016. Thesis, Univerzitet u Beogradu. Accessed April 12, 2021. https://fedorabg.bg.ac.rs/fedora/get/o:12592/bdef:Content/get.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Cvijović, Goran M., 1971-. “Sekrecija insulina i insulinska senzitivnost perifernih tkiva pre i nakon radikalnog lečenja primarnog hiperparatireoidizma.” 2016. Web. 12 Apr 2021.

Vancouver:

Cvijović, Goran M. 1. Sekrecija insulina i insulinska senzitivnost perifernih tkiva pre i nakon radikalnog lečenja primarnog hiperparatireoidizma. [Internet] [Thesis]. Univerzitet u Beogradu; 2016. [cited 2021 Apr 12]. Available from: https://fedorabg.bg.ac.rs/fedora/get/o:12592/bdef:Content/get.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Cvijović, Goran M. 1. Sekrecija insulina i insulinska senzitivnost perifernih tkiva pre i nakon radikalnog lečenja primarnog hiperparatireoidizma. [Thesis]. Univerzitet u Beogradu; 2016. Available from: https://fedorabg.bg.ac.rs/fedora/get/o:12592/bdef:Content/get

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Sydney

4. Clifton-Bligh, Phillip. Studies in Calcium, Parathyroid Hormone and Calcitonin Metabolism and Associated Skeletal Disorders .

Degree: 2018, University of Sydney

URL: http://hdl.handle.net/2123/18554

► The association of hyperparathyroidism with Paget’s disease, the changes in bone mineral density after parathyroidectomy, the surgical experience with a large number of patients with… (more)

▼ The association of hyperparathyroidism with Paget’s disease, the changes in bone mineral density after parathyroidectomy, the surgical experience with a large number of patients with hyperparathyroidism, the findings of stable bone mineral density and renal function in hyperparathyroid patients during long term follow up, and, most importantly, in a large study continued over several decades, the reduced life expectancy of patients with primary hyrperparathyroidism are described. The effective use of salmon calcitonin in a large number of patients with Paget’s disease, the use of pentagastrin to stimulate calcitonin release in persons with suspected occult medullary thyroid carcinoma, the evaluation of the impact of quantified exercise on circulating calcitonin, the evaluation of the interaction of circulating calcitonin with osteoblastic and osteoclastic function in bone in patients with chronic renal failure are described. The usefulness of the measurement of bone mineral density in the diagnosis and follow up of patients with osteoporosis, the value of the use of intravenous pamidronate in the treatment of osteoporosis, the finding that bone mineral density is a predictor of mortality in patients with chronic renal failure, the finding that long term treatment of postmenopausal women with formononetin reduces serum LDL cholesterol but does not preserve bone mineral density, the finding of low bone mineral density in persons with chronic fatigue syndrome, the failure of supplemental vitamin D to preserve bone mineral density in post-menopausal women, the effect of inhaled steroids on the bone mineral density of children, the finding that the heterozygous C282Y HFE mutation in postmenopausal women is associated with low bone mineral density and that venesection in a premenopausal woman with haemochromatosis improved bone mineral density are described. The findings of a high serum vasopressin in persons with hypercalcaemia and a high serum 1,25-OH vitamin D in a person with T-cell lymphoma are described. An extensive study of the role of FGF-23 in the clinical manifestations of oncogenic osteomalacia, and a unique study of cell function in a patient with fibrogenesis imperfecta ossium are described. The first description of diabetes insipidus in a patient with hypoparathyroidism is presented.

Subjects/Keywords: calcium; calcitonin; hyperparathyroidism; osteoporosis; fibrogenesis; FGF-23

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Clifton-Bligh, P. (2018). Studies in Calcium, Parathyroid Hormone and Calcitonin Metabolism and Associated Skeletal Disorders . (Thesis). University of Sydney. Retrieved from http://hdl.handle.net/2123/18554

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Clifton-Bligh, Phillip. “Studies in Calcium, Parathyroid Hormone and Calcitonin Metabolism and Associated Skeletal Disorders .” 2018. Thesis, University of Sydney. Accessed April 12, 2021. http://hdl.handle.net/2123/18554.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Clifton-Bligh, Phillip. “Studies in Calcium, Parathyroid Hormone and Calcitonin Metabolism and Associated Skeletal Disorders .” 2018. Web. 12 Apr 2021.

Vancouver:

Clifton-Bligh P. Studies in Calcium, Parathyroid Hormone and Calcitonin Metabolism and Associated Skeletal Disorders . [Internet] [Thesis]. University of Sydney; 2018. [cited 2021 Apr 12]. Available from: http://hdl.handle.net/2123/18554.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Clifton-Bligh P. Studies in Calcium, Parathyroid Hormone and Calcitonin Metabolism and Associated Skeletal Disorders . [Thesis]. University of Sydney; 2018. Available from: http://hdl.handle.net/2123/18554

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Oulu

5. Vierimaa, O. (Outi). Multiple Endocrine Neoplasia Type 1 (MEN1) and Pituitary Adenoma Predisposition (PAP) in Northern Finland.

Degree: 2008, University of Oulu

URL: http://urn.fi/urn:isbn:9789514288227

► Abstract Multiple endocrine neoplasia type 1 (MEN1) is an inherited syndrome characterized by parathyroid, gastroenteropancreatic and pituitary neuroendocrine tumours. In Northern Finland, two founder mutations… (more)

▼ Abstract Multiple endocrine neoplasia type 1 (MEN1) is an inherited syndrome characterized by parathyroid, gastroenteropancreatic and pituitary neuroendocrine tumours. In Northern Finland, two founder mutations of the MEN1 gene (1466del12, 1657insC) accounting for the majority of the MEN1 cases, have common ancestors born in the 18th and 19th centuries, respectively. Three small clusters of familial pituitary adenoma have also been detected, two of which could be linked by genealogy to a common ancestral couple born in the 18th century. Clinical evaluation of 82 MEN1 mutation carriers showed that age was a risk factor for most of the MEN1-related manifestations. In the whole group, nonfunctional pancreatic tumour (NFPT) was more common in the frameshift/nonsense mutation carriers (odds ratio 3.26; 95% confidence interval 1.27–8.33, P = 0.014), whereas gastrinoma was more common in the in-frame/missense mutation carriers (OR 6.77, CI 1.31–35.0, P = 0.022). In the founder mutation carriers, the 1657insC mutation predicted the risk for NFPT (OR 3.56, CI 1.29–9.83, P = 0.015), while the 1466del12 mutation was associated with the risk for gastrinoma (OR 15.1, CI 1.73–131.9, P = 0.014). The mean ages at death of the 32 obligatory MEN1 founder mutation carriers born between 1728 and 1929 were compared to those of the 29 spouses and sex-matched life expectancy estimates derived from Finnish national statistics. The ages at death of the mutation carrier males (61.1 ± 12.0 years) and females (67.2 ± 10.7 years) did not differ from the control groups. PAP (pituitary adenoma predisposition) locus was mapped in the chromosome region 11q12–11q13 by whole-genome single-nucleotide polymorphism genotyping. Combining the linkage and the gene expression array data, AIP (aryl hydrocarbon receptor interacting protein) was chosen for sequencing. The nonsense mutation Q14X was identified in the affected (acromegaly, gigantism, prolactinoma) family members and in four other patients. Loss of heterozygosity was detected in pituitary adenomas of AIP mutation carriers. Mutation analysis of MEN1, HRPT2 (hyperparathyroidism 2), CASR (calcium-sensing receptor), CDKN1B (cyclin-dependent kinase inhibitor 1B) and AIP genes was performed in primary hyperparathyroidism patients with features of inherited predisposition. One out of 29 patients was found to have the 1466del12 mutation, while no mutations were detected in other genes.

Subjects/Keywords: genetic predisposition; multiple endocrine neoplasia type 1; pituitary adenoma; primary hyperparathyroidism

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Vierimaa, O. (. (2008). Multiple Endocrine Neoplasia Type 1 (MEN1) and Pituitary Adenoma Predisposition (PAP) in Northern Finland. (Doctoral Dissertation). University of Oulu. Retrieved from http://urn.fi/urn:isbn:9789514288227

Chicago Manual of Style (16^th Edition):

Vierimaa, O (Outi). “Multiple Endocrine Neoplasia Type 1 (MEN1) and Pituitary Adenoma Predisposition (PAP) in Northern Finland.” 2008. Doctoral Dissertation, University of Oulu. Accessed April 12, 2021. http://urn.fi/urn:isbn:9789514288227.

MLA Handbook (7^th Edition):

Vierimaa, O (Outi). “Multiple Endocrine Neoplasia Type 1 (MEN1) and Pituitary Adenoma Predisposition (PAP) in Northern Finland.” 2008. Web. 12 Apr 2021.

Vancouver:

Vierimaa O(. Multiple Endocrine Neoplasia Type 1 (MEN1) and Pituitary Adenoma Predisposition (PAP) in Northern Finland. [Internet] [Doctoral dissertation]. University of Oulu; 2008. [cited 2021 Apr 12]. Available from: http://urn.fi/urn:isbn:9789514288227.

Council of Science Editors:

Vierimaa O(. Multiple Endocrine Neoplasia Type 1 (MEN1) and Pituitary Adenoma Predisposition (PAP) in Northern Finland. [Doctoral Dissertation]. University of Oulu; 2008. Available from: http://urn.fi/urn:isbn:9789514288227

Vilnius University

6. Beiša, Virgilijus. Minimaliai invazinė endokrininių liaukų chirurgija.

Degree: Review of scientific papers submitted for habilitation procedure, Medicine, 2009, Vilnius University

URL: http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2009~D_20090611_130851-96243 ;

►

Habilitacijos procedūrai teikiamoje mokslo darbų apžvalgoje apibendrinama minimaliai invazinės endokrininių liaukų chirurgijos patirtis Vilniaus universiteto Pilvo chirurgijos centre. Apžvelgtos minimaliai invazinės skydliaukės operacijos, išanalizuoti ir… (more)

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Habilitacijos procedūrai teikiamoje mokslo darbų apžvalgoje apibendrinama minimaliai invazinės endokrininių liaukų chirurgijos patirtis Vilniaus universiteto Pilvo chirurgijos centre. Apžvelgtos minimaliai invazinės skydliaukės operacijos, išanalizuoti ir apibendrinti dviejų klinikinių studijų rezultatai. 2004-2006 m. atliktoje perspektyvioje atsitiktinių imčių studijoje ,,Endoskopinės adrenalektomijos dviejų metodų įvertinimas“ pateikti ir išanalizuoti 70 pacientų, operuotų dėl įvairios antinksčių patologijos dviem minimaliai invaziniais būdais (laparoskopiniu bei endoskopiniu retroperitoniniu), rezultatai. Išanalizuota operacijos trukmės priklausomybė nuo antinksčio naviko dydžio, paciento kūno masės, palyginta kraujo netektis operacijos metu, operacinių komplikacijų skaičius. Įvertinus visus duomenis, prieita išvados, kad abu operacijos būdai geri, tačiau laparoskopinės adrenalektomijos išmokstama greičiau. 2005-2007 m. atliktame darbe ,,Minimaliai invazinė fokusuota ir tradicinė paratiroidektomija, gydant pirminį hiperparatiroidizmą: perspektyvioji, atsitiktinių imčių studija“ pateikiami pirminiu hiperparatiroidizmu sergančių pacientų, operuotų dviem būdais, gydymo rezultatai. Atsitiktinių imčių būdu 47 pacientai suskirstyti į dvi grupes: operuotų minimaliai invaziniu būdu (24 pacientai) ir operuotų tradiciniu Kocherio būdu (23 pacientai). Išanalizuota prieskydinės liaukos adenomos instrumentinių tyrimų diagnostinė vertė, palyginta operacijos trukmė, komplikacijų skaičius... [toliau žr. visą tekstą]

The experience of minimally invasive endocrine surgery accumulated at Vilnius University Centre of Abdominal Surgery is presented in this review of scientific publications submitted for habilitation procedure. The material concerning minimally invasive thyroid gland operations is summarized and the results of two clinical trials are evaluated. The results of prospective randomized study “Evaluation of two methods endoscopic adrenalectomy” were presented and analyzed; this study included 70 patients who underwent surgery for various pathology of adrenal glands; one group of the patients underwent laparoscopic minimally invasive operation and another one – endoscopic retroperitoneal minimally invasive surgery. The relationship between the size of adrenal gland tumour, patients’ body weight and duration of operation was analyzed; blood loss and rate of operative complications were compared. The evaluation of all data showed that both methods of surgery were acceptable; however, laparoscopic adrenalectomy was more was easier to learn. Clinical study “Minimally invasive focused and traditional parathyroidectomy for treatment of primary hyperparathyroidism: a prospective randomized study” was performed during the period since 2005 till 2007; the results of treatment of patients by means of two methods of surgery were presented. The patients (n = 47) were randomized into two groups; one group included 24 patients who were operated on using minimally invasive technique and another... [to full text]

Subjects/Keywords: Laparoskopinė adrenalektomija; Pirminis hiperparatiroidizmas; Neurostimuliacija; Laparoscopic adrenalectomy; Primary hyperparathyroidism; Neurostimulation

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Beiša, Virgilijus. (2009). Minimaliai invazinė endokrininių liaukų chirurgija. (Thesis). Vilnius University. Retrieved from http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2009~D_20090611_130851-96243 ;

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Beiša, Virgilijus. “Minimaliai invazinė endokrininių liaukų chirurgija.” 2009. Thesis, Vilnius University. Accessed April 12, 2021. http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2009~D_20090611_130851-96243 ;.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Beiša, Virgilijus. “Minimaliai invazinė endokrininių liaukų chirurgija.” 2009. Web. 12 Apr 2021.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete

Vancouver:

Beiša, Virgilijus. Minimaliai invazinė endokrininių liaukų chirurgija. [Internet] [Thesis]. Vilnius University; 2009. [cited 2021 Apr 12]. Available from: http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2009~D_20090611_130851-96243 ;.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Beiša, Virgilijus. Minimaliai invazinė endokrininių liaukų chirurgija. [Thesis]. Vilnius University; 2009. Available from: http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2009~D_20090611_130851-96243 ;

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation

7. Staykova, Svetla / Стайкова, Светла. Diagnosis and Management of Mineral and Bone Disorders in Patients with Chronic Kidney Disease on Conservative and Dialysis Treatment /// Диагностика и лечение на минералните и костни нарушения при болни с хронични бъбречни заболявания на консервативно и диализно лечение.

Degree: 2018, Medical University of Varna

URL: http://repository.mu-varna.bg/handle/nls/403

► [EN] Purpose of the dissertation thesis is to analyse the diagnostic, clinical and therapeutic aspects of BMD-CKD in the course of conservative and haemodialysis treatment… (more)

▼ [EN] Purpose of the dissertation thesis is to analyse the diagnostic, clinical and therapeutic aspects of BMD-CKD in the course of conservative and haemodialysis treatment by examining the diagnostic and prognostic value of contemporary biomarkers for the development of secondary hyperparathyroidism and BMD-CKD; imaging studies of variations of the parathyroid gland and bone-dental changes; comparison of the clinical efficacy of calcimimetics and paricalcitol in the development of sHPT and BMD; analysis of the dynamic influence of phosphor-binding binders on markers of BMD-CKD; traceability and safety; appreciation of combination treatment with vit.K2 and calcitriol; examining individual quality of life and developing an algorithm for BMD-CKD. The study was conducted between 1.1.2015 and 31.12.2017 with 338 patients with CKD and on HD in St.Marina University Hospital - Varna. The work proves the diagnostic and prognostic value of the complex analysis of the indicators BMD-CKD as a result of medication and HD treatment; elevated levels of FGF-23 at an early stage represent a prognostic marker for risk of cardiovascular diseases; increased levels of OC and BAP in HD with high level of PTH testify to HTBD-sHPT. Image studies for evaluation of parathyroid glands in sHPT have a significant role. Calcimimetic and paricalcitol suppress the secretion of PTH and shorten period of hyper Ca. Renagel is shown to control hyper P and a decrease FGF-23. Vit.K2 may be combined with medications used to treat BMD and protect against calcifications. Dental changes change BMD and should be treated. The questionnaire and algorithm we have modified is a reliable basis for a complex and individualized approach. /////////////// /////////////// [BG] Цел на дисертационната разработка е анализ на диагностичните, клинични и терапевтични аспекти на КМН-ХБЗ в хода на консервативното и хемодиализно лечение чрез изследване на диагностичната и прогностична стойност на съвременни биомаркери за развитие на вторичен хиперпаратиреоидизъм и КМН-ХБЗ; образни изследвания на измененията на ПЩЖ и костно-дентални промени; съпоставка на клиничната ефективност на калцимиметици и парикалцитол при развитието на ВтХПТ и КМН-ХБЗ; анализ на динамичното влияние на фосфор-свързващите байндери върху маркери на КМН-ХБЗ; проследена ефективност и безопасност; апробиране комбинираното лечение с вит.К2 и калцитриол; изследване на индивидуално качество на живот и разработване на алгоритъм за КМН-ХБЗ. Изследването е проведено между 1.1.2015 и 31.12.2017 с 338 болни с ХБЗ и на ХД в УМБАЛ „Св. Марина“–Варна. Трудът доказва диагностично-прогностичната стойност на комплексното анализиране на показателите КМН-ХБЗ в резултат на медикаментозно и ХД лечение; Повишените нива на FGF-23 в ранен стадий представляват прогностичен маркер за риска от ССЗ; Повишените нива на ОК и ВАР при ХД с висок ПТХ свидетелстват за HTBD-sHPT. Образните изследвания за оценка на ПТЖ при ВтХПТ имат значима роля. Калцимиметици и парикалцитол потискат секрецията на ПТХ и скъсяват периода на хипер Ca. Ренагел…

Subjects/Keywords: chronic kidney disease (CKD); haemodialysis; hyperparathyroidism; mineral; bone disorder; Нефрология / Nephrology

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APA (6^th Edition):

Staykova, Svetla / Стайкова, �. (2018). Diagnosis and Management of Mineral and Bone Disorders in Patients with Chronic Kidney Disease on Conservative and Dialysis Treatment /// Диагностика и лечение на минералните и костни нарушения при болни с хронични бъбречни заболявания на консервативно и диализно лечение. (Thesis). Medical University of Varna. Retrieved from http://repository.mu-varna.bg/handle/nls/403

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Staykova, Svetla / Стайкова, Светла. “Diagnosis and Management of Mineral and Bone Disorders in Patients with Chronic Kidney Disease on Conservative and Dialysis Treatment /// Диагностика и лечение на минералните и костни нарушения при болни с хронични бъбречни заболявания на консервативно и диализно лечение.” 2018. Thesis, Medical University of Varna. Accessed April 12, 2021. http://repository.mu-varna.bg/handle/nls/403.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Staykova, Svetla / Стайкова, Светла. “Diagnosis and Management of Mineral and Bone Disorders in Patients with Chronic Kidney Disease on Conservative and Dialysis Treatment /// Диагностика и лечение на минералните и костни нарушения при болни с хронични бъбречни заболявания на консервативно и диализно лечение.” 2018. Web. 12 Apr 2021.

Vancouver:

Staykova, Svetla / Стайкова �. Diagnosis and Management of Mineral and Bone Disorders in Patients with Chronic Kidney Disease on Conservative and Dialysis Treatment /// Диагностика и лечение на минералните и костни нарушения при болни с хронични бъбречни заболявания на консервативно и диализно лечение. [Internet] [Thesis]. Medical University of Varna; 2018. [cited 2021 Apr 12]. Available from: http://repository.mu-varna.bg/handle/nls/403.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Staykova, Svetla / Стайкова �. Diagnosis and Management of Mineral and Bone Disorders in Patients with Chronic Kidney Disease on Conservative and Dialysis Treatment /// Диагностика и лечение на минералните и костни нарушения при болни с хронични бъбречни заболявания на консервативно и диализно лечение. [Thesis]. Medical University of Varna; 2018. Available from: http://repository.mu-varna.bg/handle/nls/403

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Gothenburg / Göteborgs Universitet

8. Hedman, Ingmar, 1942-. Studies of water clear cell hyperplasia of the parathyroid glands and radiation-induced hyperparathyroidism.

Degree: 1983, University of Gothenburg / Göteborgs Universitet

URL: http://hdl.handle.net/2077/11540

Subjects/Keywords: Medicin Allmänt Hyperparathyroidism; Hyperplasia

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APA (6^th Edition):

Hedman, Ingmar, 1. (1983). Studies of water clear cell hyperplasia of the parathyroid glands and radiation-induced hyperparathyroidism. (Thesis). University of Gothenburg / Göteborgs Universitet. Retrieved from http://hdl.handle.net/2077/11540

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Hedman, Ingmar, 1942-. “Studies of water clear cell hyperplasia of the parathyroid glands and radiation-induced hyperparathyroidism.” 1983. Thesis, University of Gothenburg / Göteborgs Universitet. Accessed April 12, 2021. http://hdl.handle.net/2077/11540.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Hedman, Ingmar, 1942-. “Studies of water clear cell hyperplasia of the parathyroid glands and radiation-induced hyperparathyroidism.” 1983. Web. 12 Apr 2021.

Vancouver:

Hedman, Ingmar 1. Studies of water clear cell hyperplasia of the parathyroid glands and radiation-induced hyperparathyroidism. [Internet] [Thesis]. University of Gothenburg / Göteborgs Universitet; 1983. [cited 2021 Apr 12]. Available from: http://hdl.handle.net/2077/11540.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Hedman, Ingmar 1. Studies of water clear cell hyperplasia of the parathyroid glands and radiation-induced hyperparathyroidism. [Thesis]. University of Gothenburg / Göteborgs Universitet; 1983. Available from: http://hdl.handle.net/2077/11540

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Michigan State University

9. Buckner, Beverly. Induced hyperparathyroidism in the rat.

Degree: MS, 1959, Michigan State University

URL: http://etd.lib.msu.edu/islandora/object/etd:10776

Subjects/Keywords: Hyperparathyroidism; Parathyroid glands – Diseases

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Buckner, B. (1959). Induced hyperparathyroidism in the rat. (Masters Thesis). Michigan State University. Retrieved from http://etd.lib.msu.edu/islandora/object/etd:10776

Chicago Manual of Style (16^th Edition):

Buckner, Beverly. “Induced hyperparathyroidism in the rat.” 1959. Masters Thesis, Michigan State University. Accessed April 12, 2021. http://etd.lib.msu.edu/islandora/object/etd:10776.

MLA Handbook (7^th Edition):

Buckner, Beverly. “Induced hyperparathyroidism in the rat.” 1959. Web. 12 Apr 2021.

Vancouver:

Buckner B. Induced hyperparathyroidism in the rat. [Internet] [Masters thesis]. Michigan State University; 1959. [cited 2021 Apr 12]. Available from: http://etd.lib.msu.edu/islandora/object/etd:10776.

Council of Science Editors:

Buckner B. Induced hyperparathyroidism in the rat. [Masters Thesis]. Michigan State University; 1959. Available from: http://etd.lib.msu.edu/islandora/object/etd:10776

10. Guaraciaba Oliveira Ferrari. Efeito da associação do carbonato de magnésio com acetato de cálcio (OSVAREN®) no controle do fósforo, no hiperparatireoidismo secundário e no remodelamento ósseo em ratos urêmicos.

Degree: 2012, University of São Paulo

URL: http://www.teses.usp.br/teses/disponiveis/5/5148/tde-29102012-163540/

►

Introdução: O quelante de fósforo (P) Osvaren® foi lançado recentemente no mercado internacional para tratamento da hiperfosfatemia nos pacientes com Doença Renal Crônica (DRC). Não… (more)

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Introdução: O quelante de fósforo (P) Osvaren® foi lançado recentemente no mercado internacional para tratamento da hiperfosfatemia nos pacientes com Doença Renal Crônica (DRC). Não existem estudos experimentais com esta medicação. Objetivo: Avaliar a ação deste quelante no tratamento do Distúrbio Mineral e Ósseo (DMO) de ratos com DRC induzida por adenina e por nefrectomia 5/6 (NX5/6). Métodos: Experimento 1: Durante 4 semanas, ratos Wistar receberam dieta com adenina [2 semanas (0,75%); 2 semanas (0,50%)] e então foram divididos em 3 grupos para receber dieta padrão (grupo DRC); dieta padrão com 3% de Acetato de Cálcio (grupo Ca); e dieta padrão com 3% de Osvaren® (grupo CaMg). Um grupo Controle (função renal normal) recebeu a dieta padrão durante todo o estudo. Ao final de cinco semanas de tratamento os animais foram sacrificados. Experimento 2: ratos da mesma espécie foram submetidos à NX5/6, divididos em grupos como no experimento 1 para receberem os quelantes de P imediatamente após a nefrectomia, e sacrificados após 9 semanas. Nos dois experimentos foram coletados soro, fêmures, aortas e paratireóides para análise bioquímica, histomorfometria óssea, pesquisa de calcificação vascular (CV) e imunohistoquímica de paratireóides, respectivamente. Resultados: Experimento 1: Os animais que receberam adenina apresentaram níveis maiores de creatinina, PTH, P e magnésio (Mg) que os do grupo Controle. Os quelantes de P reduziram a fração de excreção de P (FeP), mas não o P sérico, enquanto os níveis de PTH, FGF23 e calcitriol diminuíram de forma não significativa nos grupos tratados. O Mg sérico foi significativamente maior no grupo CaMg, enquanto maior calciúria, mais CV e menor marcação pelo PCNA nas paratireóides foram observadas no grupo Ca. Os animais que receberam adenina apresentaram doença óssea mista e ambos os quelantes de P melhoraram a remodelação, mas favoreceram a um acúmulo ainda maior de osteóide. Experimento 2: Da mesma forma que no experimento 1, o animais submetidos à NX5/6 evoluíram com uremia, e os efeitos dos quelantes no PTH, na CV e nas paratireóides foram similares. No entanto, o grupo CaMg apresentou mortalidade de 54% (vs 20% no grupo Ca), além de retardo na mineralização óssea. Conclusão: O tipo de nefropatia pode ter influência no efeito do quelante de P Osvaren®, já que o acúmulo de Mg provavelmente foi o responsável pela maior mortalidade e déficit de mineralização observados no experimento 2. Em relação ao efeito como quelante de P, o Osvaren® foi equivalente ao acetato de cálcio, mas este último está associado a maior sobrecarga de cálcio e a CV. O acúmulo de osteóide observado em ambos os experimentos parece ser o preço pago pela reduzida absorção intestinal de P favorecida pelos quelantes no hiperpatireoidismo secundário severo e esse efeito deveria ser avaliado em pacientes em diálise

Introduction: Osvaren® is a phosphate (P) binder that has been recently introduced for Chronic Kidney Disease (CKD) patients therapy. However, it has not been tested in experimental models yet.…

Advisors/Committee Members: Rosa Maria Affonso Moyses, Lucia da Conceição Andrade, Maria Eugenia Fernandes Canziani, Rosilene Motta Elias, Daniel Rinaldi dos Santos.

Subjects/Keywords: Doenças ósseas; Fósforo; Hiperparatireoidismo; Nefropatias; Bone disease; Hyperparathyroidism; Nephropathies; Phosphorus

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Ferrari, G. O. (2012). Efeito da associação do carbonato de magnésio com acetato de cálcio (OSVAREN®) no controle do fósforo, no hiperparatireoidismo secundário e no remodelamento ósseo em ratos urêmicos. (Doctoral Dissertation). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/5/5148/tde-29102012-163540/

Chicago Manual of Style (16^th Edition):

Ferrari, Guaraciaba Oliveira. “Efeito da associação do carbonato de magnésio com acetato de cálcio (OSVAREN®) no controle do fósforo, no hiperparatireoidismo secundário e no remodelamento ósseo em ratos urêmicos.” 2012. Doctoral Dissertation, University of São Paulo. Accessed April 12, 2021. http://www.teses.usp.br/teses/disponiveis/5/5148/tde-29102012-163540/.

MLA Handbook (7^th Edition):

Ferrari, Guaraciaba Oliveira. “Efeito da associação do carbonato de magnésio com acetato de cálcio (OSVAREN®) no controle do fósforo, no hiperparatireoidismo secundário e no remodelamento ósseo em ratos urêmicos.” 2012. Web. 12 Apr 2021.

Vancouver:

Ferrari GO. Efeito da associação do carbonato de magnésio com acetato de cálcio (OSVAREN®) no controle do fósforo, no hiperparatireoidismo secundário e no remodelamento ósseo em ratos urêmicos. [Internet] [Doctoral dissertation]. University of São Paulo; 2012. [cited 2021 Apr 12]. Available from: http://www.teses.usp.br/teses/disponiveis/5/5148/tde-29102012-163540/.

Council of Science Editors:

Ferrari GO. Efeito da associação do carbonato de magnésio com acetato de cálcio (OSVAREN®) no controle do fósforo, no hiperparatireoidismo secundário e no remodelamento ósseo em ratos urêmicos. [Doctoral Dissertation]. University of São Paulo; 2012. Available from: http://www.teses.usp.br/teses/disponiveis/5/5148/tde-29102012-163540/

11. André Albuquerque Silveira. Análise crítica do decaimento no nível do paratormônio intra-operatório para prognóstico de sucesso da paratireoidectomia no controle precoce do hiperparatireoidismo secundário e terciário.

Degree: 2018, University of São Paulo

URL: http://www.teses.usp.br/teses/disponiveis/5/5132/tde-20032019-092826/

► INTRODUÇÃO: A monitorização do paratormônio rápido (PTHr) é padrão no tratamento cirúrgico do hiperparatireoidismo primário, para garantir a retirada da paratireoide doente e preservação das… (more)

▼ INTRODUÇÃO: A monitorização do paratormônio rápido (PTHr) é padrão no tratamento cirúrgico do hiperparatireoidismo primário, para garantir a retirada da paratireoide doente e preservação das saudáveis. Sua utilidade no tratamento cirúrgico do hiperparatireoidismo secundário à doença renal crônica é controversa. Esse estudo tem como objetivo verificar: 1) se a medida PTHr auxilia na predição do resultado cirúrgico precoce; 2) se existem diferenças de comportamento do PTHr entre pacientes dialíticos e transplantados; 3) se existem diferenças de comportamento do PTHr entre modalidades de operações distintas; 4) a acurácia do método em predizer controle do hiperparatireoidismo renal. MÉTODOS: Trata-se de estudo de coorte retrospectiva e prospectiva observacional, de pacientes com diagnóstico de HPTr, dialítico ou persistência após transplante renal, submetidos a paratireoidectomia total ou subtotal em único centro, no período de 2011 a 2016. Durante a cirurgia, realizamos coletas seriadas do PTHr, sendo três dessas amostras antes da exérese das glândulas paratireoides (basal periférico, basal central e pré-retirada), e duas após ressecção (10 min e 15 min). O critério de queda porcentual igual ou maior a 80% do maior valor entre as amostras basais, em 10 minutos, foi arbitrado preditor de êxito intra-operatório. Os pacientes foram seguidos durante intervalos regulares (15 dias, 3, 6 e 12 meses). Foram divididos em dois grupos (sucesso e falha da operação) de acordo com o controle dos níveis de PTH, cálcio e fósforo conforme consensos internacionais, ao término do seguimento de 1 ano. RESULTADOS: Duzentos e vinte e oito pacientes foram elegíveis, sendo 186 (81,6%) dialíticos e 42 (18,4%) transplantados. A paratireoidectomia alcançou sucesso em 92,1% (210/228) e falha em 7,9% (18/228) dos pacientes, sem diferenças de resultados entre grupos de diagnósticos diferentes e/ou tipos de operações distintas. O principal motivo de falha foi presença de glândula supranumerária, em 61,1% dos casos (11/18). A amostra basal central (BC) representou o real maior valor basal do PTHr para ambos os diagnósticos, porém com maior chance de picos do PTHr na amostra pré-retirada (PRE) nos pacientes transplantados. Após remoção da massa de tecido paratireóideo doente, os níveis de PTHr foram menores em 10 minutos quando comparados com as amostras basais (resultado estatisticamente significativo) para todos diagnósticos, tipos de operações e desfechos terapêuticos. No grupo sucesso, houve diferença estatisticamente significativa, entre as medidas de 10 e 15 minutos entre si, com valores menores em 15 minutos, enquanto que no grupo falha, sem distinção de 10 e 15 minutos entre si e com valores médios maiores em 15 min. Os valores do PTHr foram maiores no paciente dialítico quando comparados com transplantado, em todas as amostras (p < 0,001). No grupo sucesso, os pacientes dialíticos e transplantados, e os pacientes dialíticos submetidos a exérese total e subtotal apresentaram porcentual de queda do PTHr semelhantes em 10 e 15 minutos para as… Advisors/Committee Members: Fábio Luiz de Menezes Montenegro, Nivaldo Alonso, Marília D'Elboux Guimarães Brescia, Luiz Carlos Conti de Freitas, Monique Nakayama Ohe.

Subjects/Keywords: Hiperparatireoidismo; Hiperparatireoidismo secundário; Hormônio paratireóideo; Insuficiência renal crônica; Monitorização intraoperatória; Paratireoidectomia; Hyperparathyroidism secondary; Hyperparathyroidism; Monitoring intraoperative; Parathyroid hormone; Parathyroidectomy; Renal insufficiency chronic

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Silveira, A. A. (2018). Análise crítica do decaimento no nível do paratormônio intra-operatório para prognóstico de sucesso da paratireoidectomia no controle precoce do hiperparatireoidismo secundário e terciário. (Doctoral Dissertation). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/5/5132/tde-20032019-092826/

Chicago Manual of Style (16^th Edition):

Silveira, André Albuquerque. “Análise crítica do decaimento no nível do paratormônio intra-operatório para prognóstico de sucesso da paratireoidectomia no controle precoce do hiperparatireoidismo secundário e terciário.” 2018. Doctoral Dissertation, University of São Paulo. Accessed April 12, 2021. http://www.teses.usp.br/teses/disponiveis/5/5132/tde-20032019-092826/.

MLA Handbook (7^th Edition):

Silveira, André Albuquerque. “Análise crítica do decaimento no nível do paratormônio intra-operatório para prognóstico de sucesso da paratireoidectomia no controle precoce do hiperparatireoidismo secundário e terciário.” 2018. Web. 12 Apr 2021.

Vancouver:

Silveira AA. Análise crítica do decaimento no nível do paratormônio intra-operatório para prognóstico de sucesso da paratireoidectomia no controle precoce do hiperparatireoidismo secundário e terciário. [Internet] [Doctoral dissertation]. University of São Paulo; 2018. [cited 2021 Apr 12]. Available from: http://www.teses.usp.br/teses/disponiveis/5/5132/tde-20032019-092826/.

Council of Science Editors:

Silveira AA. Análise crítica do decaimento no nível do paratormônio intra-operatório para prognóstico de sucesso da paratireoidectomia no controle precoce do hiperparatireoidismo secundário e terciário. [Doctoral Dissertation]. University of São Paulo; 2018. Available from: http://www.teses.usp.br/teses/disponiveis/5/5132/tde-20032019-092826/

Technical University of Lisbon

12. Gomes, Catarina Afonso. Canine primary hyperparathyroidism : clinical approach to hypercalcaemia.

Degree: 2016, Technical University of Lisbon

URL: http://www.rcaap.pt/detail.jsp?id=oai:www.repository.utl.pt:10400.5/12669

►

Dissertação de Mestrado Integrado em Medicina Veterinária

Canine primary hyperparathyroidism (PHPTH) is an endocrine disorder, where one or more parathyroid glands autonomously produce and secrete… (more)

▼

Dissertação de Mestrado Integrado em Medicina Veterinária

Canine primary hyperparathyroidism (PHPTH) is an endocrine disorder, where one or more parathyroid glands autonomously produce and secrete parathyroid hormone (PTH), which results in hypercalcaemia (Feldman, 2010). Diagnosis of PHPTH is achieved when there are inappropriate PTH concentrations (normal or increased) in the presence of elevated ionised calcium (iCa) concentration with no other identifiable cause (Skelly, 2012). iCa is the only active fraction of calcium and does not always correlate to total calcium, which is why iCa should be used to assess serum calcium status (Schenck & Chew, 2008). PHPTH is usually diagnosed after detection of hypercalcaemia in a blood analysis performed for unrelated reasons, as clinical signs are often not perceived by the owners (Feldman, Hoar, Pollard, & Nelson, 2005; Feldman, 2015a). Treatment by parathyroidectomy, percutaneous ultrasound-guided ethanol ablation or percutaneous ultrasound-guided heat ablation is curative and prognosis is excellent for treated dogs, but hypocalcaemia is a frequent postoperative complication (Caplan, 2013; Feldman, 2015a; Flanders, 2003; Nelson, 2009; Rasor, Pollard, & Feldman, 2007; Séguin & Brownlee, 2012). The retrospective study had the objective of characterising a sample of six dogs diagnosed with PHPTH at Anderson Moores Veterinary Specialists and analyse the procedures and tests conducted in the clinical approach to previously identified hypercalcaemia.

RESUMO - Hiperparatiroidismo primário canino: abordagem clínica à hipercalcémia - O hiperparatiroidismo primário canino (PHPTH) é uma doença endócrina, na qual uma ou mais glândulas paratiróides produzem e secretam hormona paratiroideia ou paratormona (PTH) autonomamente, o que resulta em hipercalcémia (Feldman, 2010). O diagnóstico de PHPTH é efectuado quando existem concentrações de PTH inapropriadas (normais ou aumentadas) na presença de concentrações aumentadas de cálcio ionizado (iCa) sem outra causa identificável (Skelly, 2012). O iCa é a única fracção activa do cálcio e nem sempre se correlaciona com o cálcio total, motivo pelo qual o iCa deve ser utilizado para avaliar o cálcio em circulação (Schenck & Chew, 2008) O PHPTH é normalmente diagnosticado após a detecção de hipercalcémia numa análise sanguínea efectuada por motivos não relacionados, uma vez que os sinais clínicos normalmente não são identificados pelos donos (Feldman, Hoar, Pollard, & Nelson, 2005; Feldman, 2015a).. O tratamento com paratiroidectomia, ablação percutânea com etanol guiada por ultra-som ou ablação percutânea com calor guiada por ultra-som é curativo e tem um prognóstico excelente para animais tratados, embora a hipocalcémia seja uma complicação póscirurgica frequente (Caplan, 2013; Feldman, 2015a; Flanders, 2003; Nelson, 2009; Rasor, Pollard, & Feldman, 2007; Séguin & Brownlee, 2012). O estudo retrospectivo deste trabalho teve como objectivo a caracterização de uma amostra de seis cães diagnosticados com PHPTH na Anderson Moores Veterinary…

Advisors/Committee Members: Walker, David John.

Subjects/Keywords: Primary hyperparathyroidism; parathyroid hormone; hypercalcaemia; ionised calcium; hiperparatiroidismo primário; hormona paratiroideia; paratormona; hipercalcémia; cálcio ionizado

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APA (6^th Edition):

Gomes, C. A. (2016). Canine primary hyperparathyroidism : clinical approach to hypercalcaemia. (Thesis). Technical University of Lisbon. Retrieved from http://www.rcaap.pt/detail.jsp?id=oai:www.repository.utl.pt:10400.5/12669

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Gomes, Catarina Afonso. “Canine primary hyperparathyroidism : clinical approach to hypercalcaemia.” 2016. Thesis, Technical University of Lisbon. Accessed April 12, 2021. http://www.rcaap.pt/detail.jsp?id=oai:www.repository.utl.pt:10400.5/12669.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Gomes, Catarina Afonso. “Canine primary hyperparathyroidism : clinical approach to hypercalcaemia.” 2016. Web. 12 Apr 2021.

Vancouver:

Gomes CA. Canine primary hyperparathyroidism : clinical approach to hypercalcaemia. [Internet] [Thesis]. Technical University of Lisbon; 2016. [cited 2021 Apr 12]. Available from: http://www.rcaap.pt/detail.jsp?id=oai:www.repository.utl.pt:10400.5/12669.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Gomes CA. Canine primary hyperparathyroidism : clinical approach to hypercalcaemia. [Thesis]. Technical University of Lisbon; 2016. Available from: http://www.rcaap.pt/detail.jsp?id=oai:www.repository.utl.pt:10400.5/12669

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

13. 崎村, 千香. Can the use of intraoperative intact parathyroid hormone monitoring be abandoned in patients with hyperparathyroidism? : 原発性副甲状腺機能亢進症における術中intact-PTHモニタリングの必要性の検討.

Degree: 博士(医学), 2013, Nagasaki University / 長崎大学

URL: http://hdl.handle.net/10069/35243

► Background Ultrasound (US) and technetium-99m sestamibi scintigraphy (MIBI) are used to determine the localization of abnormal glands in cases of primary hyperparathyroidism (PHPT). Intraoperative intact… (more)

Subjects/Keywords: Intraoperative intact parathyroid hormone monitoring; Primary hyperparathyroidism; Technetium-99m sestamibi scintigraphy; Ultrasound

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APA (6^th Edition):

崎村, �. (2013). Can the use of intraoperative intact parathyroid hormone monitoring be abandoned in patients with hyperparathyroidism? : 原発性副甲状腺機能亢進症における術中intact-PTHモニタリングの必要性の検討. (Thesis). Nagasaki University / 長崎大学. Retrieved from http://hdl.handle.net/10069/35243

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

崎村, 千香. “Can the use of intraoperative intact parathyroid hormone monitoring be abandoned in patients with hyperparathyroidism? : 原発性副甲状腺機能亢進症における術中intact-PTHモニタリングの必要性の検討.” 2013. Thesis, Nagasaki University / 長崎大学. Accessed April 12, 2021. http://hdl.handle.net/10069/35243.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

崎村, 千香. “Can the use of intraoperative intact parathyroid hormone monitoring be abandoned in patients with hyperparathyroidism? : 原発性副甲状腺機能亢進症における術中intact-PTHモニタリングの必要性の検討.” 2013. Web. 12 Apr 2021.

Vancouver:

崎村 �. Can the use of intraoperative intact parathyroid hormone monitoring be abandoned in patients with hyperparathyroidism? : 原発性副甲状腺機能亢進症における術中intact-PTHモニタリングの必要性の検討. [Internet] [Thesis]. Nagasaki University / 長崎大学; 2013. [cited 2021 Apr 12]. Available from: http://hdl.handle.net/10069/35243.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

崎村 �. Can the use of intraoperative intact parathyroid hormone monitoring be abandoned in patients with hyperparathyroidism? : 原発性副甲状腺機能亢進症における術中intact-PTHモニタリングの必要性の検討. [Thesis]. Nagasaki University / 長崎大学; 2013. Available from: http://hdl.handle.net/10069/35243

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

14. Albaldawi, Basma. Bone mineral density in patients with lithium-associated hyperparathyroidism.

Degree: Medical Sciences, 2019, Örebro University

URL: http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-77771

► Background: Lithium is the most effective long-term treatment for bipolar disease. It has, however,been associated with hypercalcemia and hyperparathyroidism. The aim of the study… (more)

Subjects/Keywords: lithium; hyperparathyroidism; hypercalcemia; bone mineral density; Medical and Health Sciences; Medicin och hälsovetenskap

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APA (6^th Edition):

Albaldawi, B. (2019). Bone mineral density in patients with lithium-associated hyperparathyroidism. (Thesis). Örebro University. Retrieved from http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-77771

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Albaldawi, Basma. “Bone mineral density in patients with lithium-associated hyperparathyroidism.” 2019. Thesis, Örebro University. Accessed April 12, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-77771.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Albaldawi, Basma. “Bone mineral density in patients with lithium-associated hyperparathyroidism.” 2019. Web. 12 Apr 2021.

Vancouver:

Albaldawi B. Bone mineral density in patients with lithium-associated hyperparathyroidism. [Internet] [Thesis]. Örebro University; 2019. [cited 2021 Apr 12]. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-77771.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Albaldawi B. Bone mineral density in patients with lithium-associated hyperparathyroidism. [Thesis]. Örebro University; 2019. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-77771

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University College Cork

15. Kinsella, Sinéad. Vascular calcification and mineral bone disorder in chronic kidney disease.

Degree: 2013, University College Cork

URL: http://hdl.handle.net/10468/1299

► Chronic Kidney Disease (CKD), osteoporosis and mild hyponatremia are all prevalent chronic conditions that may coexist and are often under-recognized. Mineral-Bone Disorder begins early in… (more)

▼ Chronic Kidney Disease (CKD), osteoporosis and mild hyponatremia are all prevalent chronic conditions that may coexist and are often under-recognized. Mineral-Bone Disorder begins early in the natural history of CKD and results in complex abnormalities of bone which ultimately confers a well-established increased risk of fragility fractures in End Stage Kidney Disease. Hyponatremia is a novel, usually renal mediated metabolic perturbation, that most commonly occurs independently of the stage of renal dysfunction but which may also predispose to increased fracture risk. The extent -if any- to which either early stages of renal dysfunction or the presence of hyponatremia contribute to fracture occurrence in the general population, independently of osteoporosis, is unclear. Renal transplantation is the treatment of choice for ESKD and although it restores endogenous renal function it typically fails to normalize either the long term cardiovascular or fracture risk. One potential mechanism contributing to these elevated long-term risks and to diminished Health Related Quality of Life is persistent, post-transplant hyperparathyroidism. In this study we retrospectively examine the association of renal function and serum sodium with Bone Mineral Density and fracture occurrence in a retrospective cohort of 1930 female members of the general population who underwent routine DXA scan. We then prospectively recruited a cohort of 90 renal transplant recipients in order to examine the association of post transplant parathyroid hormone (PTH) level with measures of CKD Mineral Bone Disorder, including, DXA Bone Mineral Density, Vascular Calcification (assessed using both abdominal radiography and CT techniques, as well as indirectly by carotid-femoral Pulse Wave Velocity) and Quality of Life (using the Short Form-12 and a PTH specific symptom score). In the retrospective DXA cohort, moderate CKD (eGFR 30-59ml/min/1.73m2) and hyponatremia (<135mmol/L) were associated with fracture occurrence, independently of BMD, with an adjusted Odds Ratio (95% Confidence Interval), of 1.37 (1.0, 1.89) and 2.25 (1.24, 4.09) respectively. In the renal transplant study, PTH was independently associated with the presence of osteoporosis, adjusted Odds Ratio (95% Confidence Interval), 1.15 (per 10ng/ml increment), (1.04, 1.26). The presence of osteoporosis but not PTH was independently associated with measures of vascular calcification, adjusted ß (95% Confidence Interval), 12.45, (1.16, 23.75). Of the eight quality-of-life domains examined, post-transplant PTH (per 10ng/ml increment), was only significantly and independently associated with reduced Physical Functioning, (95% Confidence Interval), 1.12 (1.01, 1.23). CKD and hyponatremia are both common health problems that may contribute to fracture occurrence in the general population, a major on-going public health concern. PTH and decreased Bone Mineral Density may signal sub-optimal long-term outcomes post renal transplantation, influencing bone and vascular health and to a limited extent long… Advisors/Committee Members: Eustace, Joe.

Subjects/Keywords: Vascular calcification; Renal transplantation; Mineral bone disorder; Chronic kidney disease; Hyperparathyroidism; Kidneys – Diseases; Kidneys – Transplantation

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Kinsella, S. (2013). Vascular calcification and mineral bone disorder in chronic kidney disease. (Thesis). University College Cork. Retrieved from http://hdl.handle.net/10468/1299

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Kinsella, Sinéad. “Vascular calcification and mineral bone disorder in chronic kidney disease.” 2013. Thesis, University College Cork. Accessed April 12, 2021. http://hdl.handle.net/10468/1299.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Kinsella, Sinéad. “Vascular calcification and mineral bone disorder in chronic kidney disease.” 2013. Web. 12 Apr 2021.

Vancouver:

Kinsella S. Vascular calcification and mineral bone disorder in chronic kidney disease. [Internet] [Thesis]. University College Cork; 2013. [cited 2021 Apr 12]. Available from: http://hdl.handle.net/10468/1299.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Kinsella S. Vascular calcification and mineral bone disorder in chronic kidney disease. [Thesis]. University College Cork; 2013. Available from: http://hdl.handle.net/10468/1299

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Melbourne

16. Vu, Thuy Dan Thuy. Bone microstructure and material composition in endocrine disorders.

Degree: 2018, University of Melbourne

URL: http://hdl.handle.net/11343/216912

► In the general population, fractures are a significant healthcare issue. However, fractures also complicate several endocrine disorders. The overall aim of my study was to… (more)

▼ In the general population, fractures are a significant healthcare issue. However, fractures also complicate several endocrine disorders. The overall aim of my study was to investigate the changes in bone structure and material composition underlying bone fragility in a number of endocrine diseases such as type 1 and type 2 diabetes mellitus as well as patients with PTH excess and PTH deficiency. High-resolution peripheral quantitative computed tomography was used to acquire images of the distal radius and tibia in cases and controls. Bone structure was assessed by the standard analysis protocol from the manufacturers that uses a threshold base algorithm in the type 1 and type 2 diabetes studies. A non-threshold base algorithm was used to analyze bone structure and matrix mineral density in the PTH excess and PTH deficiency study. The main findings were that patients with type 1 diabetes had no significant deficits in cortical and trabecular bone relative to controls. Patients with T1DM had a tendency towards lower bone formation and bone resorption markers. Patients with type 2 diabetes had similar cortical morphology whereas trabecular bone was better maintained than controls. These results are consistent with higher BMD in the spine and hip as well as lower bone remodelling markers observed in diabetic patients. PTH excess is deleterious to both cortical and trabecular bone. In patients with untreated primary hyperparathyroidism (PHPT), the normal or high trabecular density reported in several studies is likely to be the result of inclusion of cortical remnants in the medullary compartment. In patients with untreated PHPT, there was a left shift of the void-matrix mineralization density distribution curve relative to controls due to increased cortical porosity. Cortical and trabecular deficits in untreated PHPT may not be completely reversible with surgical treatment. Patients with PTH deficiency due to secondary rather than primary hypoparathyroidism have better maintained cortical and trabecular bone relative to controls as well as higher matrix mineral density. Similar results were found in women and in men. There was a rightward shift of the void bone matrix mineralization distribution curve for patients with hypoparathyroidism relative to controls. In conclusion, patients with type 1 and type 2 diabetes may have underlying bone fragility predisposing to fractures, but my study failed to identify microstructural abnormalities. Further work is needed to determine whether abnormalities in the material properties of bone may account for the increased fracture risk seen in diabetes. Patients with PTH excess have deficits to both cortical and trabecular bone. The normal or high trabecular density reported in several studies is likely to be the result of inclusion of cortical remnants in the medullary compartment. Patients with PTH deficiency due to secondary hypoparathyroidism rather than primary hypoparathyroidism have better maintained cortical and trabecular bone morphology as well as higher matrix…

Subjects/Keywords: bone microstructure; material composition; type 1 diabetes mellitus; type 2 diabetes mellitus; hyperparathyroidism; hypoparathyroidism

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Vu, T. D. T. (2018). Bone microstructure and material composition in endocrine disorders. (Doctoral Dissertation). University of Melbourne. Retrieved from http://hdl.handle.net/11343/216912

Chicago Manual of Style (16^th Edition):

Vu, Thuy Dan Thuy. “Bone microstructure and material composition in endocrine disorders.” 2018. Doctoral Dissertation, University of Melbourne. Accessed April 12, 2021. http://hdl.handle.net/11343/216912.

MLA Handbook (7^th Edition):

Vu, Thuy Dan Thuy. “Bone microstructure and material composition in endocrine disorders.” 2018. Web. 12 Apr 2021.

Vancouver:

Vu TDT. Bone microstructure and material composition in endocrine disorders. [Internet] [Doctoral dissertation]. University of Melbourne; 2018. [cited 2021 Apr 12]. Available from: http://hdl.handle.net/11343/216912.

Council of Science Editors:

Vu TDT. Bone microstructure and material composition in endocrine disorders. [Doctoral Dissertation]. University of Melbourne; 2018. Available from: http://hdl.handle.net/11343/216912

17. Granjon, David. Modeling of Calcium Homeostasis in the Rat and its Perturbations : Modélisation de l'homéostasie du calcium chez le rat et ses perturbations.

Degree: Docteur es, Sciences de la vie, 2016, Université Pierre et Marie Curie – Paris VI

URL: http://www.theses.fr/2016PA066399

►

Cette thèse de mathématiques appliquées en physiologie rénale a pour thème principal l'étude de l'homéostasie du calcium à travers le développement d'un modèle mathématique à… (more)

▼

Cette thèse de mathématiques appliquées en physiologie rénale a pour thème principal l'étude de l'homéostasie du calcium à travers le développement d'un modèle mathématique à l'échelle de l'organisme. Nous cherchons à répondre à certaines questions soulevées par les néphrologues dans le cas de pathologies impliquant la formation de calculs rénaux ou de calcifications. Nous examinons notamment les cas de l'hypercalciurie observée durant l'hyperparathyroïdie primaire dont les causes ne sont pas élucidées ainsi que les mécanismes de complexation du calcium et phosphate et notamment les conséquences d'une infusion intraveineuse de phosphate sur l'homéostasie du calcium. Notre modèle est composé d'équations différentielles décrivant la dynamique du calcium dans les compartiments impliqué dans son métabolisme (intestin, os, reins) ainsi que les mécanismes de régulation par l'hormone parathyroïdienne (PTH), la vitamine D3 et le récepteur sensible au calcium (CaSR). Ce modèle est par ailleurs couplé à un modèle de l'homéostasie du phosphate. Les résultats de ce modèle suggèrent que la présence ou non d'une hypercalciurie lors de l'hyperparathyroïdie primaire peut être expliquée par des mécanismes antagonistes dans la branche ascendante large de Henle, avec d'un côté le CaSR inhibant la réabsorption de calcium et de l'autre la PTH diminuant l'excrétion de calcium. Nous concluons que l'infusion intraveineuse de phosphate induit une hypocalcémie majeure, due principalement à la précipitation du calcium et du phosphate dans le plasma et dans l'os. En outre, cette étude suggère un retard dans l'activation de la synthèse de PTH par le phosphate.

This thesis of applied mathematics in renal physiology focuses on the study of calcium homeostasis, through the development of a mathematical model at the organism scale. This model is built based upon recent experimental studies as well as previous models in the field. We aim to answer several questions raised by nephrologists regarding diseases involving calcium stone formation or calcifications. In particular, we are interested in the origins of the hypercalciuria observed during primary hyperparathyroidism, the causes of which remain to be elucidated, the effects of bone resorption inhibition by bisphosphonates on calcium metabolism, as well as the consequences of an intravenous infusion of phosphate on calcium homeostasis. Our model is composed of differential equations describing the dynamics of calcium in the compartments involved in its metabolism (intestine, bone and kidneys), as well as complex feedback mechanisms by parathyroid hormone (PTH), vitamin D3 and the calcium sensing receptor (CaSR). Besides, this model is coupled to a phosphate homeostasis model. This model suggests that the variable presence of hypercalciuria during primary hyperparathyroidism can be explained by counteracting mechanisms in the thick ascending limb of Henle, involving on one hand the calcium sensing receptor, which inhibits calcium reabsorption, and on the other hand PTH which decreases calcium…

Advisors/Committee Members: Edwards, Aurélie (thesis director), Bonny, Olivier (thesis director).

Subjects/Keywords: Calcium; Phosphate; Pth; Vitamine D3; Homéostasie; Modèle mathématique; Calcium; Homeostasis; Primary hyperparathyroidism; 571.19

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Granjon, D. (2016). Modeling of Calcium Homeostasis in the Rat and its Perturbations : Modélisation de l'homéostasie du calcium chez le rat et ses perturbations. (Doctoral Dissertation). Université Pierre et Marie Curie – Paris VI. Retrieved from http://www.theses.fr/2016PA066399

Chicago Manual of Style (16^th Edition):

Granjon, David. “Modeling of Calcium Homeostasis in the Rat and its Perturbations : Modélisation de l'homéostasie du calcium chez le rat et ses perturbations.” 2016. Doctoral Dissertation, Université Pierre et Marie Curie – Paris VI. Accessed April 12, 2021. http://www.theses.fr/2016PA066399.

MLA Handbook (7^th Edition):

Granjon, David. “Modeling of Calcium Homeostasis in the Rat and its Perturbations : Modélisation de l'homéostasie du calcium chez le rat et ses perturbations.” 2016. Web. 12 Apr 2021.

Vancouver:

Granjon D. Modeling of Calcium Homeostasis in the Rat and its Perturbations : Modélisation de l'homéostasie du calcium chez le rat et ses perturbations. [Internet] [Doctoral dissertation]. Université Pierre et Marie Curie – Paris VI; 2016. [cited 2021 Apr 12]. Available from: http://www.theses.fr/2016PA066399.

Council of Science Editors:

Granjon D. Modeling of Calcium Homeostasis in the Rat and its Perturbations : Modélisation de l'homéostasie du calcium chez le rat et ses perturbations. [Doctoral Dissertation]. Université Pierre et Marie Curie – Paris VI; 2016. Available from: http://www.theses.fr/2016PA066399

18. Cínthia Ribas Martorelli. Avaliação sequencial do metabolismo de cálcio e fósforo com ênfase na determinação do fator de crescimento de fibroblastos 23 (FGF-23) e da excreção fracionada de fósforo urinária (uFEP) de cães com doença renal crônica submetidos a terapia com células-tronco mesenquimal.

Degree: 2016, University of São Paulo

URL: http://www.teses.usp.br/teses/disponiveis/10/10136/tde-23022017-091455/

► A hiperfosfatemia está relacionada com o hiperparatireoidismo secundário renal (HPTSR) e com a progressão da doença renal crônica (DRC). A retenção de fósforo estimula a… (more)

▼ A hiperfosfatemia está relacionada com o hiperparatireoidismo secundário renal (HPTSR) e com a progressão da doença renal crônica (DRC). A retenção de fósforo estimula a síntese do fator de crescimento de fibroblastos 23 (FGF-23), o qual promove fosfatúria, com o objetivo de evitar o aparecimento de hiperfosfatemia. Atualmente, o tratamento disponível para DRC é de manutenção e, portanto, novas estratégias para evitar a progressão da DRC seriam de grande relevância. Recentemente têm sido demonstrado o papel da célula-tronco mesenquimal (CTM) em minimizar os mecanismos inflamatórios e imunológicos envolvidos na progressão da DRC. Portanto, o estudo teve como hipótese de que a CTM possa evitar ou controlar a progressão para o HPTSR, investigada por meio da avaliação de biomarcadores do metabolismo de fósforo, ou seja, as concentrações sérica de fósforo (sP), FGF-23, cálcio total e cálcio ionizado, bem como a excreção fracionada de fósforo urinária (uFEP) em cães com DRC nos estágios 2 (Grupo A) e 3 (Grupo B), submetidos ou não a terapia com CTM, bem como investigar se os valores elevados de FGF-23 estariam relacionados com o menor tempo de sobrevida. Trata-se de um estudo prospectivo, longitudinal, duplo-cego e randomizado em que foram avaliados 22 cães com DRC, tratados com solução fisiológica (SF) ou CTM, avaliados a cada 30 a 45 dias em 12 momentos (T0 a T12). No Grupo A (n= 9; SF: n= 6, CTM: n= 3) todos os cães eram normofosfatêmicos no momento inicial do acompanhamento (T0) e foi observado níveis elevados de FGF-23 em 33,3% dos cães (3 de 9), assim como o aumento de uFEP foi detectado em 33,3% dos casos (3 de 9). A média ± EPM dos valores de FGF-23 sérico do Grupo A foi de 481,5 ± 75,23pg/mL. Já no Grupo B (n = 13; SF: n = 6, CTM: n = 7), todos os cães apresentaram altas concentrações séricas de FGF-23 desde T0 (média ± EPM de 12744 ± 6879pg/mL), sendo que 53,8% dos cães eram normofosfatêmicos. A média ± EPM de fósforo sérico em T0, T6 e T12 ou momento do óbito no Grupo A e B foi de 3,74 ± 0,13mg/dL e 6,40 ± 0,54mg/dL. Ao longo do curso da doença, o desenvolvimento de hiperfosfatemia foi observada em apenas 11,1% dos cães do Grupo A e em 84,6% dos cães do Grupo B. O Grupo B (SF e CTM) apresentou valores mais elevados de FGF-23 do que o Grupo A (SF e CTM), e foi detectada diferença estatística entre os dois grupos. A uFEP nos cães dos Grupos A e B em T0, T6 e T12 ou óbito obteve média ± EPM de 20,93 ± 3,92% e 24,05 ± 2,22%, respectivamente. Além disso, a sobrevida foi menor no Grupo B, a qual estava associada com hiperfosfatemia intensa, altas concentrações de FGF-23 e diminuição da uFEP. Dessa forma, em cães DRC normofosfatêmicos, a presença de aumentos de uFEP e de FGF-23 parece terem atuado como marcador precoce do HPTSR. Em contrapartida, nos estágios tardios da DRC, o aumento de FGF-23 associado a diminuição da uFEP pode indicar mau prognóstico. Em relação à terapia com CTM nos cães com DRC, de acordo com o número de cães avaliados e os resultados obtidos, não foi possível concluir de forma contundente sobre… Advisors/Committee Members: Marcia Mery Kogika, Lucia da Conceição Andrade, Márcia de Oliveira Sampaio Gomes, Viviani de Marco, Talita Rojas Cunha Sanches.

Subjects/Keywords: Canina; Célula-tronco; FGF-23; Fosfatúria; Hiperfosfatemia; Canine; FGF- 23; Hyperparathyroidism; Hyperphosphatemia; Phosphaturia; Stem cell

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Martorelli, C. R. (2016). Avaliação sequencial do metabolismo de cálcio e fósforo com ênfase na determinação do fator de crescimento de fibroblastos 23 (FGF-23) e da excreção fracionada de fósforo urinária (uFEP) de cães com doença renal crônica submetidos a terapia com células-tronco mesenquimal. (Doctoral Dissertation). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/10/10136/tde-23022017-091455/

Chicago Manual of Style (16^th Edition):

Martorelli, Cínthia Ribas. “Avaliação sequencial do metabolismo de cálcio e fósforo com ênfase na determinação do fator de crescimento de fibroblastos 23 (FGF-23) e da excreção fracionada de fósforo urinária (uFEP) de cães com doença renal crônica submetidos a terapia com células-tronco mesenquimal.” 2016. Doctoral Dissertation, University of São Paulo. Accessed April 12, 2021. http://www.teses.usp.br/teses/disponiveis/10/10136/tde-23022017-091455/.

MLA Handbook (7^th Edition):

Martorelli, Cínthia Ribas. “Avaliação sequencial do metabolismo de cálcio e fósforo com ênfase na determinação do fator de crescimento de fibroblastos 23 (FGF-23) e da excreção fracionada de fósforo urinária (uFEP) de cães com doença renal crônica submetidos a terapia com células-tronco mesenquimal.” 2016. Web. 12 Apr 2021.

Vancouver:

Martorelli CR. Avaliação sequencial do metabolismo de cálcio e fósforo com ênfase na determinação do fator de crescimento de fibroblastos 23 (FGF-23) e da excreção fracionada de fósforo urinária (uFEP) de cães com doença renal crônica submetidos a terapia com células-tronco mesenquimal. [Internet] [Doctoral dissertation]. University of São Paulo; 2016. [cited 2021 Apr 12]. Available from: http://www.teses.usp.br/teses/disponiveis/10/10136/tde-23022017-091455/.

Council of Science Editors:

Martorelli CR. Avaliação sequencial do metabolismo de cálcio e fósforo com ênfase na determinação do fator de crescimento de fibroblastos 23 (FGF-23) e da excreção fracionada de fósforo urinária (uFEP) de cães com doença renal crônica submetidos a terapia com células-tronco mesenquimal. [Doctoral Dissertation]. University of São Paulo; 2016. Available from: http://www.teses.usp.br/teses/disponiveis/10/10136/tde-23022017-091455/

Universiteit Utrecht

19. Smit, Pieter Casper. Image guided, minimally invasive adenomectomy for solitary gland disease in primary hyperparathyroidism.

Degree: 2001, Universiteit Utrecht

URL: http://dspace.library.uu.nl:8080/handle/1874/391

► Introduction: Since the introduction in the 1970s of the unilateral approach in surgery for primary hyperparathyroidism by Wang, authors have increasingly been recommending limited forms… (more)

▼ Introduction: Since the introduction in the 1970s of the unilateral approach in surgery for primary hyperparathyroidism by Wang, authors have increasingly been recommending limited forms of parathyroid surgery. Although unilateral explorations reduce operation time and admission days, decrease operative risk and give better cosmetic results, the debate about the best surgical treatment for primary hyperparathyroidism has never been settled. Bilateralists oppose less invasive approaches because they estimate the incidence of multiple gland disease to be as high as 30%. However, in spite of a systematic bilateral exploration of the neck in search of the diseased parathyroid gland, with identification and estimation of the size of all parathyroid tissue, in only 44% of cases are four glands identified, in 37% three, and in 19% less than three. In chapter 1 we reported an exceptional case of persistent hyperparathyroidism (due to a non-descended inferior parathyroid) after extensive bilateral exploration, illustrating a clinical dilemma that can be encountered in parathyroid surgery. Imaging carried out prior to re-exploration and including, among other methods, ultrasonography and computed tomography, revealed a parathyroid adenoma at the level of the mandibular angle and the hyoid bone. Guided by the imaging results the adenoma was successfully resected by a local direct procedure taking less than 10 minutes. In general, the main reason an adenoma is not found during exploration is the variability in location, rather than variety in the number of glands. It is therefore of pivotal importance to understand not only the anatomy, but also the embryology of the parathyroid glands. As radiologist John Doppman succinctly stated, If you are an experienced parathyroid surgeon and not able to find a tumor, you cannot have looked high enough. Since primary hyperparathyroidism can be diagnosed with nearly 100% accuracy and successfully treated in more than 95% of cases, surgery is the treatment of choice. The gold standard in parathyroid surgery has been conventional neck exploration (CNE), and with success rates exceeding 95% and virtually no complications nothing more seemed left to be desired. However, it cannot be denied that there is a discrepancy between the extent of the operation and the size of the offending gland in the majority of patients. Encouraged by the pace of development in methods of imaging (resulting in increased accuracy), combined with the knowledge that primary hyperparathyroidism is caused by a solitary adenoma in at least 85% of cases, and our experience of the relatively simple and quick MIA procedure (chapter 1) we wondered whether such a direct, minimally invasive strategy could be utilized for the more common cases of primary hyperparathyroidism as well. For this purpose we formulated the following hypothesis (chapter 3): A substantial group of patients with primary hyperparathyroidism can be successfully treated by limited access surgery after preoperative localization studies and may thus be…

Subjects/Keywords: Geneeskunde; minimally invasive; primary hyperparathyroidism; hyperparathyreoïdie; mia; cne

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Smit, P. C. (2001). Image guided, minimally invasive adenomectomy for solitary gland disease in primary hyperparathyroidism. (Doctoral Dissertation). Universiteit Utrecht. Retrieved from http://dspace.library.uu.nl:8080/handle/1874/391

Chicago Manual of Style (16^th Edition):

Smit, Pieter Casper. “Image guided, minimally invasive adenomectomy for solitary gland disease in primary hyperparathyroidism.” 2001. Doctoral Dissertation, Universiteit Utrecht. Accessed April 12, 2021. http://dspace.library.uu.nl:8080/handle/1874/391.

MLA Handbook (7^th Edition):

Smit, Pieter Casper. “Image guided, minimally invasive adenomectomy for solitary gland disease in primary hyperparathyroidism.” 2001. Web. 12 Apr 2021.

Vancouver:

Smit PC. Image guided, minimally invasive adenomectomy for solitary gland disease in primary hyperparathyroidism. [Internet] [Doctoral dissertation]. Universiteit Utrecht; 2001. [cited 2021 Apr 12]. Available from: http://dspace.library.uu.nl:8080/handle/1874/391.

Council of Science Editors:

Smit PC. Image guided, minimally invasive adenomectomy for solitary gland disease in primary hyperparathyroidism. [Doctoral Dissertation]. Universiteit Utrecht; 2001. Available from: http://dspace.library.uu.nl:8080/handle/1874/391

Kyoto University / 京都大学

20. Hayakawa, Nobuyuki. A comparison between 11C-methionine PET/CT and MIBI SPECT/CT for localization of parathyroid adenomas/hyperplasia : 副甲状腺腺腫/過形成の局在診断における11C-メチオニン PET/CTとMIBI SPECT/CTの比較.

Degree: 博士(医学), 2015, Kyoto University / 京都大学

URL: http://hdl.handle.net/2433/199175 ; http://dx.doi.org/10.14989/doctor.k18866

新制・課程博士

甲第18866号

医博第3977号

Subjects/Keywords: 11C-methionine; PET/CT; 99mTc-sestamibi; SPECT/CT; hyperparathyroidism

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Hayakawa, N. (2015). A comparison between 11C-methionine PET/CT and MIBI SPECT/CT for localization of parathyroid adenomas/hyperplasia : 副甲状腺腺腫/過形成の局在診断における11C-メチオニン PET/CTとMIBI SPECT/CTの比較. (Thesis). Kyoto University / 京都大学. Retrieved from http://hdl.handle.net/2433/199175 ; http://dx.doi.org/10.14989/doctor.k18866

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Hayakawa, Nobuyuki. “A comparison between 11C-methionine PET/CT and MIBI SPECT/CT for localization of parathyroid adenomas/hyperplasia : 副甲状腺腺腫/過形成の局在診断における11C-メチオニン PET/CTとMIBI SPECT/CTの比較.” 2015. Thesis, Kyoto University / 京都大学. Accessed April 12, 2021. http://hdl.handle.net/2433/199175 ; http://dx.doi.org/10.14989/doctor.k18866.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Hayakawa, Nobuyuki. “A comparison between 11C-methionine PET/CT and MIBI SPECT/CT for localization of parathyroid adenomas/hyperplasia : 副甲状腺腺腫/過形成の局在診断における11C-メチオニン PET/CTとMIBI SPECT/CTの比較.” 2015. Web. 12 Apr 2021.

Vancouver:

Hayakawa N. A comparison between 11C-methionine PET/CT and MIBI SPECT/CT for localization of parathyroid adenomas/hyperplasia : 副甲状腺腺腫/過形成の局在診断における11C-メチオニン PET/CTとMIBI SPECT/CTの比較. [Internet] [Thesis]. Kyoto University / 京都大学; 2015. [cited 2021 Apr 12]. Available from: http://hdl.handle.net/2433/199175 ; http://dx.doi.org/10.14989/doctor.k18866.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Hayakawa N. A comparison between 11C-methionine PET/CT and MIBI SPECT/CT for localization of parathyroid adenomas/hyperplasia : 副甲状腺腺腫/過形成の局在診断における11C-メチオニン PET/CTとMIBI SPECT/CTの比較. [Thesis]. Kyoto University / 京都大学; 2015. Available from: http://hdl.handle.net/2433/199175 ; http://dx.doi.org/10.14989/doctor.k18866

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

21. Kluijfhout, WP. Parathyroid Imaging.

Degree: 2017, University Utrecht

URL: http://dspace.library.uu.nl/handle/1874/348052 ; URN:NBN:NL:UI:10-1874-348052 ; urn:isbn:978-94-6233-537-0 ; URN:NBN:NL:UI:10-1874-348052 ; http://dspace.library.uu.nl/handle/1874/348052

► A colloquial saying described the best localization before parathyroid surgery was finding a good surgeon. While it is still important to have a high volume… (more)

Subjects/Keywords: Parathyroid imaging; primary hyperparathyroidism; 18F-Fluorocholine; PET

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Kluijfhout, W. (2017). Parathyroid Imaging. (Doctoral Dissertation). University Utrecht. Retrieved from http://dspace.library.uu.nl/handle/1874/348052 ; URN:NBN:NL:UI:10-1874-348052 ; urn:isbn:978-94-6233-537-0 ; URN:NBN:NL:UI:10-1874-348052 ; http://dspace.library.uu.nl/handle/1874/348052

Chicago Manual of Style (16^th Edition):

Kluijfhout, WP. “Parathyroid Imaging.” 2017. Doctoral Dissertation, University Utrecht. Accessed April 12, 2021. http://dspace.library.uu.nl/handle/1874/348052 ; URN:NBN:NL:UI:10-1874-348052 ; urn:isbn:978-94-6233-537-0 ; URN:NBN:NL:UI:10-1874-348052 ; http://dspace.library.uu.nl/handle/1874/348052.

MLA Handbook (7^th Edition):

Kluijfhout, WP. “Parathyroid Imaging.” 2017. Web. 12 Apr 2021.

Vancouver:

Kluijfhout W. Parathyroid Imaging. [Internet] [Doctoral dissertation]. University Utrecht; 2017. [cited 2021 Apr 12]. Available from: http://dspace.library.uu.nl/handle/1874/348052 ; URN:NBN:NL:UI:10-1874-348052 ; urn:isbn:978-94-6233-537-0 ; URN:NBN:NL:UI:10-1874-348052 ; http://dspace.library.uu.nl/handle/1874/348052.

Council of Science Editors:

Kluijfhout W. Parathyroid Imaging. [Doctoral Dissertation]. University Utrecht; 2017. Available from: http://dspace.library.uu.nl/handle/1874/348052 ; URN:NBN:NL:UI:10-1874-348052 ; urn:isbn:978-94-6233-537-0 ; URN:NBN:NL:UI:10-1874-348052 ; http://dspace.library.uu.nl/handle/1874/348052

Universitat Autònoma de Barcelona

22. Garcia Gibert, Lidia. Influencia genética en la evolución de la masa ósea tras paratiroidectomía en pacientes afectas de hiperparatiroidismo primario.

Degree: Departament de Medicina, 2016, Universitat Autònoma de Barcelona

URL: http://hdl.handle.net/10803/393874

► The primary hyperparathyroidism (PHPT) is the third most common endocrinological diagnosis and it is characterized by excessive, inadequate and poorly regulated parathyroid hormone (PTH) secretion.… (more)

▼ The primary hyperparathyroidism (PHPT) is the third most common endocrinological diagnosis and it is characterized by excessive, inadequate and poorly regulated parathyroid hormone (PTH) secretion. The bone is one of the target organs of PHPT and the presence of osteoporosis at any localitation, is indication for surgical treatment. However, the response of the bone to this treatment is not uniform and generalized in all patients. The hypothesis of this study is that the evolution of bone mass after parathyroidectomy (PTx) is related and/or conditioned by various demographic, clinical, laboratory and genetic factors. MATERIAL AND METHODS: We performed a prospective observational study between january 1999 and december 2012. The study included 159 postmenopausal women with PHPT who underwent PTx. Analytical and densitometric measurements were perfomed before PTx and at one and two years of follow-up. Also, different genetics polymorphisms related to bone-mineral metabolism and the physiopathology of PHTP were genotyped. RESULTS: The prevalence of osteoporosis is higher in women with PHPT than in the general population and the most affected bone is the cortical bone (90% of patients with PHPT has osteopenia or osteoporosis at ultradistal radius area). Bone mineral density (BMD) increases significantly after PTx in all locations (p<0,001) except in the proximal third of the distal radius (p=0,374). Younger women (P=0,016) and women with a later menopause (p=0,026) have a greater increase in BMD in the total hip (TH) after PTx, and a high BMI (p=0,008) is related with greater recovery of BMD at femoral neck (FN). A high basal PTH (p<0,01) and a greater decrease after PTx (p<0,05), are associated with a greater increase in BMD after PTx at all sites studied. A elevated basal 1,25-OH2 Vitamin D is associated with a greater increase in BMD at TH (p=0,014). A low baseline BMD is associated with a greater increase in bone mass after PTx at FN and TH level (p=0,004 and p=0,03 respectively). Genotype A/C for the rs7975232 polymorphism of the VDR gene (p=0,022) and genotype A/A for rs1042636 polymorphism of the CaSR gene (p=0,048) are most frecuently in patients with PHPT. The C allele for rs9594738 polymorphism to RANKL gene and the G allele for rs1032128 polymorphism to OPG gene have been linked to a higher baseline BMD at the lumbar spine (p=0,029 and p=0,02 respectively). The presence of the G allele of rs4646536 polymorphism of the CYP27B1 gene is associated with a greater BMD recovery after PTx at TH(p=0,006). These differences are not statistically significant if the results are corrected by the Bonferroni method. CONCLUSIONS: The most affected bone in PHPT is cortical bone; however, the higher BMD recovery after PTx is produced at the trabecular bone. Patients with more severe PHPT (higher basal PTH, greater PTH decrease after PTx, increased basal 1,25-OH2 Vitamin D and lower baseline BMD) are those with greater BMD recovery after surgery. Younger women, those with a later menopause and those with a higher BMI… Advisors/Committee Members: [email protected] (authoremail), true (authoremailshow), Nogués Solan, Xavier (director), Díez Pérez, Adolf (tutor), true (authorsendemail).

Subjects/Keywords: Hiperparatiroïdisme primari; Hiperparatiroidismo primario; Primary hyperparathyroidism; Genètica; Genética; Genetics; Massa òssia; Masa ósea; Bone mas; Ciències de la Salut; 616.4

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Garcia Gibert, L. (2016). Influencia genética en la evolución de la masa ósea tras paratiroidectomía en pacientes afectas de hiperparatiroidismo primario. (Thesis). Universitat Autònoma de Barcelona. Retrieved from http://hdl.handle.net/10803/393874

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Garcia Gibert, Lidia. “Influencia genética en la evolución de la masa ósea tras paratiroidectomía en pacientes afectas de hiperparatiroidismo primario.” 2016. Thesis, Universitat Autònoma de Barcelona. Accessed April 12, 2021. http://hdl.handle.net/10803/393874.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Garcia Gibert, Lidia. “Influencia genética en la evolución de la masa ósea tras paratiroidectomía en pacientes afectas de hiperparatiroidismo primario.” 2016. Web. 12 Apr 2021.

Vancouver:

Garcia Gibert L. Influencia genética en la evolución de la masa ósea tras paratiroidectomía en pacientes afectas de hiperparatiroidismo primario. [Internet] [Thesis]. Universitat Autònoma de Barcelona; 2016. [cited 2021 Apr 12]. Available from: http://hdl.handle.net/10803/393874.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Garcia Gibert L. Influencia genética en la evolución de la masa ósea tras paratiroidectomía en pacientes afectas de hiperparatiroidismo primario. [Thesis]. Universitat Autònoma de Barcelona; 2016. Available from: http://hdl.handle.net/10803/393874

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

23. Lockefeer, J.H.M. Nierstenen, hypercalciurie en diuretica.

Degree: 1975, Erasmus University Medical Center

URL: http://hdl.handle.net/1765/31379

textabstractGeïsoleerde nefrolithiasis moet beschouwd worden als een ziekte waarbij de vorming van stenen slechts een - zij het belangrijk - symptoom is. Daamaast bestaan echter andere afwijkingen tengevolge waarvan de steenvorming wordt bevorderd of ontstaat. Deze afwijkingen, alsmede de oorzaken ervan, zijn nog steeds niet alle bekend

Subjects/Keywords: Idiopathic hypercalciuria (IHC); hypercalciuria; normocalcemia; primary hyperparathyroidism (PHP

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Lockefeer, J. H. M. (1975). Nierstenen, hypercalciurie en diuretica. (Doctoral Dissertation). Erasmus University Medical Center. Retrieved from http://hdl.handle.net/1765/31379

Chicago Manual of Style (16^th Edition):

Lockefeer, J H M. “Nierstenen, hypercalciurie en diuretica.” 1975. Doctoral Dissertation, Erasmus University Medical Center. Accessed April 12, 2021. http://hdl.handle.net/1765/31379.

MLA Handbook (7^th Edition):

Lockefeer, J H M. “Nierstenen, hypercalciurie en diuretica.” 1975. Web. 12 Apr 2021.

Vancouver:

Lockefeer JHM. Nierstenen, hypercalciurie en diuretica. [Internet] [Doctoral dissertation]. Erasmus University Medical Center; 1975. [cited 2021 Apr 12]. Available from: http://hdl.handle.net/1765/31379.

Council of Science Editors:

Lockefeer JHM. Nierstenen, hypercalciurie en diuretica. [Doctoral Dissertation]. Erasmus University Medical Center; 1975. Available from: http://hdl.handle.net/1765/31379

24. Bonjer, Jaap. Single and multiple gland disease in primary hyperparathyroidism.

Degree: 1992, Erasmus University Medical Center

URL: http://hdl.handle.net/1765/39777

► textabstractThe scope of this thesis is: To review diagnostic procedures in primary hyperparathyroidism To review localization studies of parathyroid glands in hyperparathyroidism primary To assess… (more)

Subjects/Keywords: primary hyperparathyroidism; single and multiple gland disease

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Bonjer, J. (1992). Single and multiple gland disease in primary hyperparathyroidism. (Doctoral Dissertation). Erasmus University Medical Center. Retrieved from http://hdl.handle.net/1765/39777

Chicago Manual of Style (16^th Edition):

Bonjer, Jaap. “Single and multiple gland disease in primary hyperparathyroidism.” 1992. Doctoral Dissertation, Erasmus University Medical Center. Accessed April 12, 2021. http://hdl.handle.net/1765/39777.

MLA Handbook (7^th Edition):

Bonjer, Jaap. “Single and multiple gland disease in primary hyperparathyroidism.” 1992. Web. 12 Apr 2021.

Vancouver:

Bonjer J. Single and multiple gland disease in primary hyperparathyroidism. [Internet] [Doctoral dissertation]. Erasmus University Medical Center; 1992. [cited 2021 Apr 12]. Available from: http://hdl.handle.net/1765/39777.

Council of Science Editors:

Bonjer J. Single and multiple gland disease in primary hyperparathyroidism. [Doctoral Dissertation]. Erasmus University Medical Center; 1992. Available from: http://hdl.handle.net/1765/39777

25. Kluijfhout, WP. Parathyroid Imaging.

Degree: 2017, University Utrecht

URL: https://dspace.library.uu.nl/handle/1874/348052 ; URN:NBN:NL:UI:10-1874-348052 ; urn:isbn:978-94-6233-537-0 ; URN:NBN:NL:UI:10-1874-348052 ; https://dspace.library.uu.nl/handle/1874/348052

► A colloquial saying described the best localization before parathyroid surgery was finding a good surgeon. While it is still important to have a high volume… (more)

Subjects/Keywords: Parathyroid imaging; primary hyperparathyroidism; 18F-Fluorocholine; PET

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Kluijfhout, W. (2017). Parathyroid Imaging. (Doctoral Dissertation). University Utrecht. Retrieved from https://dspace.library.uu.nl/handle/1874/348052 ; URN:NBN:NL:UI:10-1874-348052 ; urn:isbn:978-94-6233-537-0 ; URN:NBN:NL:UI:10-1874-348052 ; https://dspace.library.uu.nl/handle/1874/348052

Chicago Manual of Style (16^th Edition):

Kluijfhout, WP. “Parathyroid Imaging.” 2017. Doctoral Dissertation, University Utrecht. Accessed April 12, 2021. https://dspace.library.uu.nl/handle/1874/348052 ; URN:NBN:NL:UI:10-1874-348052 ; urn:isbn:978-94-6233-537-0 ; URN:NBN:NL:UI:10-1874-348052 ; https://dspace.library.uu.nl/handle/1874/348052.

MLA Handbook (7^th Edition):

Kluijfhout, WP. “Parathyroid Imaging.” 2017. Web. 12 Apr 2021.

Vancouver:

Kluijfhout W. Parathyroid Imaging. [Internet] [Doctoral dissertation]. University Utrecht; 2017. [cited 2021 Apr 12]. Available from: https://dspace.library.uu.nl/handle/1874/348052 ; URN:NBN:NL:UI:10-1874-348052 ; urn:isbn:978-94-6233-537-0 ; URN:NBN:NL:UI:10-1874-348052 ; https://dspace.library.uu.nl/handle/1874/348052.

Council of Science Editors:

Kluijfhout W. Parathyroid Imaging. [Doctoral Dissertation]. University Utrecht; 2017. Available from: https://dspace.library.uu.nl/handle/1874/348052 ; URN:NBN:NL:UI:10-1874-348052 ; urn:isbn:978-94-6233-537-0 ; URN:NBN:NL:UI:10-1874-348052 ; https://dspace.library.uu.nl/handle/1874/348052

26. Smit, Pieter Casper. Image guided, minimally invasive adenomectomy for solitary gland disease in primary hyperparathyroidism.

Degree: 2001, University Utrecht

URL: https://dspace.library.uu.nl/handle/1874/391 ; URN:NBN:NL:UI:10-1874-391 ; URN:NBN:NL:UI:10-1874-391 ; https://dspace.library.uu.nl/handle/1874/391

► Introduction: Since the introduction in the 1970s of the unilateral approach in surgery for primary hyperparathyroidism by Wang, authors have increasingly been recommending limited forms… (more)

▼ Introduction: Since the introduction in the 1970s of the unilateral approach in surgery for primary hyperparathyroidism by Wang, authors have increasingly been recommending limited forms of parathyroid surgery. Although unilateral explorations reduce operation time and admission days, decrease operative risk and give better cosmetic results, the debate about the best surgical treatment for primary hyperparathyroidism has never been settled. Bilateralists oppose less invasive approaches because they estimate the incidence of multiple gland disease to be as high as 30%. However, in spite of a systematic bilateral exploration of the neck in search of the diseased parathyroid gland, with identification and estimation of the size of all parathyroid tissue, in only 44% of cases are four glands identified, in 37% three, and in 19% less than three. In chapter 1 we reported an exceptional case of persistent hyperparathyroidism (due to a non-descended inferior parathyroid) after extensive bilateral exploration, illustrating a clinical dilemma that can be encountered in parathyroid surgery. Imaging carried out prior to re-exploration and including, among other methods, ultrasonography and computed tomography, revealed a parathyroid adenoma at the level of the mandibular angle and the hyoid bone. Guided by the imaging results the adenoma was successfully resected by a local direct procedure taking less than 10 minutes. In general, the main reason an adenoma is not found during exploration is the variability in location, rather than variety in the number of glands. It is therefore of pivotal importance to understand not only the anatomy, but also the embryology of the parathyroid glands. As radiologist John Doppman succinctly stated, If you are an experienced parathyroid surgeon and not able to find a tumor, you cannot have looked high enough. Since primary hyperparathyroidism can be diagnosed with nearly 100% accuracy and successfully treated in more than 95% of cases, surgery is the treatment of choice. The gold standard in parathyroid surgery has been conventional neck exploration (CNE), and with success rates exceeding 95% and virtually no complications nothing more seemed left to be desired. However, it cannot be denied that there is a discrepancy between the extent of the operation and the size of the offending gland in the majority of patients. Encouraged by the pace of development in methods of imaging (resulting in increased accuracy), combined with the knowledge that primary hyperparathyroidism is caused by a solitary adenoma in at least 85% of cases, and our experience of the relatively simple and quick MIA procedure (chapter 1) we wondered whether such a direct, minimally invasive strategy could be utilized for the more common cases of primary hyperparathyroidism as well. For this purpose we formulated the following hypothesis (chapter 3): A substantial group of patients with primary hyperparathyroidism can be successfully treated by limited access surgery after preoperative localization studies and may thus be…

Subjects/Keywords: minimally invasive; primary hyperparathyroidism; hyperparathyreoïdie; mia; cne

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Smit, P. C. (2001). Image guided, minimally invasive adenomectomy for solitary gland disease in primary hyperparathyroidism. (Doctoral Dissertation). University Utrecht. Retrieved from https://dspace.library.uu.nl/handle/1874/391 ; URN:NBN:NL:UI:10-1874-391 ; URN:NBN:NL:UI:10-1874-391 ; https://dspace.library.uu.nl/handle/1874/391

Chicago Manual of Style (16^th Edition):

Smit, Pieter Casper. “Image guided, minimally invasive adenomectomy for solitary gland disease in primary hyperparathyroidism.” 2001. Doctoral Dissertation, University Utrecht. Accessed April 12, 2021. https://dspace.library.uu.nl/handle/1874/391 ; URN:NBN:NL:UI:10-1874-391 ; URN:NBN:NL:UI:10-1874-391 ; https://dspace.library.uu.nl/handle/1874/391.

MLA Handbook (7^th Edition):

Smit, Pieter Casper. “Image guided, minimally invasive adenomectomy for solitary gland disease in primary hyperparathyroidism.” 2001. Web. 12 Apr 2021.

Vancouver:

Smit PC. Image guided, minimally invasive adenomectomy for solitary gland disease in primary hyperparathyroidism. [Internet] [Doctoral dissertation]. University Utrecht; 2001. [cited 2021 Apr 12]. Available from: https://dspace.library.uu.nl/handle/1874/391 ; URN:NBN:NL:UI:10-1874-391 ; URN:NBN:NL:UI:10-1874-391 ; https://dspace.library.uu.nl/handle/1874/391.

Council of Science Editors:

Smit PC. Image guided, minimally invasive adenomectomy for solitary gland disease in primary hyperparathyroidism. [Doctoral Dissertation]. University Utrecht; 2001. Available from: https://dspace.library.uu.nl/handle/1874/391 ; URN:NBN:NL:UI:10-1874-391 ; URN:NBN:NL:UI:10-1874-391 ; https://dspace.library.uu.nl/handle/1874/391

27. Athanasouli, Fani. Δείκτες πρώιμης αθηρωμάτωσης και δείκτες οστικού μεταβολισμού σε ασθενείς με πρωτοπαθή υπερπαραθυρεοειδισμό.

Degree: 2015, National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ)

URL: http://hdl.handle.net/10442/hedi/36158

► Introduction: Recent evidence suggests that primary hyperparathyroidism (pHPT) is linked with hypertension and atherosclerosis, even though the results of studies are often conflicting. PHPT is… (more)

▼ Introduction: Recent evidence suggests that primary hyperparathyroidism (pHPT) is linked with hypertension and atherosclerosis, even though the results of studies are often conflicting. PHPT is found in a high proportion (2-3%) in postmenopausal women. Co-existence of non-traditional risk factors with an already adverse traditional cardiovascular (CV) risk factor profile in menopause, may substantially and unpredictably alter the net CV risk profile in this population. Methods: One hundred and two postmenopausal women with pHPT without clinically overt cardiovascular disease were consecutively recruited and were matched 1:1 for age and duration of menopause with 102 postmenopausal women with normal PTH, Ca and P levels and without clinically overt CV disease. A complete biochemical assessment was done in all patients and we used non-invasive cardiovascular techniques for identifying subclinical damage of the arterial wall (brachial artery flow - mediated dilation (FMD), pulse wave velocity (PWV), pulse wave analysis to determine the arterial pressure augmentation index (ΑΙ%) and aortic blood pressure, carotid and femoral intima - media thickness measurements (ΙΜΤ) and determination of atherosclerotic plaques by ultrasound method.Results: Postmenopausal women with pHPT had higher PTH and calcium levels, and lower levels of phosphorus and 25 hydroxyvitamin D as expected. They had also higher BMI, HBA1c, HOMA-ir, CRP and triglycerides, higher prevalence of untreated hypertension and lower prevalence of hyperlipidemia (p<0.05 for all). Concerning their hemodynamic and vascular profile, pHPT patients had higher peripheral systolic (p=0.03) and diastolic (p<0.001) and aortic systolic (p=0.002) and diastolic (p<0.001) blood pressure and marginally higher PWV (p=0.084) compared to postmenopausal women without pHPT. After adjustment for risk factors differing between the 2 groups the presence of pHPT was an independent determinant of peripheral and aortic systolic and diastolic BP only (p<0.05 for all). Further adjustment for CRP revealed that only peripheral (p=0.025) and aortic (p=0.004) diastolic BP remained significantly higher in the pHPT group. Finally, after adjustment for vitamin D3 levels the results were not altered while after adjustment for PTH levels there were no statistically significant differences in these markers between the two groups.Conclusion: These results suggest that pHPT is associated with increased peripheral and aortic blood pressure. In this correlation, PTH levels and inflammatory load seem to play a pivotal role. In contrast, a direct impact of the disease on subclinical atherosclerosis cannot be implicated despite the large number of relevant markers of measured in this study. Given the steep increase in CV risk after menopausal transition, pHPT may further aggravate incident hypertension and CV danger in postmenopausal women. Therefore, early diagnosis and careful control of blood pressure is important for these women especially when they do not fulfill the criteria for…

Subjects/Keywords: Πρωτοπαθής υπερπαραθυρεοειδισμός; Εμμηνόπαυση; Αρτηριακή πίεση; Αρτηριακή σκληρία; Αθηρωματική νόσος; Ενδοθηλιακή λειτουργία; Primary hyperparathyroidism; Menopause; Arterial hypertension; Arterial stiffness; Atheromatosis; Endothelial dysfunction

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Athanasouli, F. (2015). Δείκτες πρώιμης αθηρωμάτωσης και δείκτες οστικού μεταβολισμού σε ασθενείς με πρωτοπαθή υπερπαραθυρεοειδισμό. (Thesis). National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ). Retrieved from http://hdl.handle.net/10442/hedi/36158

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Athanasouli, Fani. “Δείκτες πρώιμης αθηρωμάτωσης και δείκτες οστικού μεταβολισμού σε ασθενείς με πρωτοπαθή υπερπαραθυρεοειδισμό.” 2015. Thesis, National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ). Accessed April 12, 2021. http://hdl.handle.net/10442/hedi/36158.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Athanasouli, Fani. “Δείκτες πρώιμης αθηρωμάτωσης και δείκτες οστικού μεταβολισμού σε ασθενείς με πρωτοπαθή υπερπαραθυρεοειδισμό.” 2015. Web. 12 Apr 2021.

Vancouver:

Athanasouli F. Δείκτες πρώιμης αθηρωμάτωσης και δείκτες οστικού μεταβολισμού σε ασθενείς με πρωτοπαθή υπερπαραθυρεοειδισμό. [Internet] [Thesis]. National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ); 2015. [cited 2021 Apr 12]. Available from: http://hdl.handle.net/10442/hedi/36158.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Athanasouli F. Δείκτες πρώιμης αθηρωμάτωσης και δείκτες οστικού μεταβολισμού σε ασθενείς με πρωτοπαθή υπερπαραθυρεοειδισμό. [Thesis]. National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ); 2015. Available from: http://hdl.handle.net/10442/hedi/36158

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

28. Φακιδάρη, Ελένη. Μεταβολές των γεωμετρικών σκελετικών χαρακτηριστικών σε ασθενείς με πρωτοπαθή υπερπαραθυροειδισμό μετά χειρουργική η συντηρητική αντιμετώπιση.

Degree: 2013, National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ)

URL: http://hdl.handle.net/10442/hedi/38547

►

The objective of the study was to evaluate the effect of parathyroidectomy (PTX) vs.35 mg ow risedronate administration on volumetric bone mineral density (vBMD) andbone… (more)

▼

The objective of the study was to evaluate the effect of parathyroidectomy (PTX) vs.35 mg ow risedronate administration on volumetric bone mineral density (vBMD) andbone geometry at the tibia in postmenopausal women with primaryhyperparathyroidism (PHPT). Our open label prospective observational studyincluded 32 postmenopausal women with PHPT as the study group. 16 underwentPTX and 16 were treated with 35 mg ow risedronate for 2 years. We assessed aBMDby DXA, vBMD, bone mineral content (BMC), cortical and trabecular area, byperipheral quantitative computed tomography (pQCT) at the tibia at baseline and attwo years. Risedronate did not result in any significant change on vBMD andstructural pQCT indices. PTX resulted in significant increase in trabBMC (6.44%)and vBMD (4.64%), with % increase being significantly higher over risedronate(p<0.05). At cortical sites there was no significant change following PTX. However,the % change in cortvBMD was higher following PTX vs. risedronate (0.39% vs. -0.26%, p<0.05). In conclusion in postmenopausal women with PHPT, PTX issuperior to ow risedronate, in terms of improvement of trabecular mineralization and vBMD at the tibia, while the effect at cortical sites is less pronounced.

Εισαγωγή : Eίναι γνωστό ότι ο πρωτοπαθής υπερπαραθυροειδισμός (ΠΥ) είναι σήμερα μία από τις συχνότερες ενδοκρινολογικές αιτίες δευτεροπαθούς οστεοπόρωσης, ακόμα και σε ασυμπτωματικούς ασθενείς, με μεγαλύτερη επίπτωση στον μετεμμηνοπαυσιακό πληθυσμό. Η διεθνής βιβλιογραφία αποδεικνύει ότι ο αυξημένος οστικός ανασχηματισμός, που είναι ένα από τα σημαντικότερα στοιχεία της νόσου, ευθύνεται μάλλον κατά ένα μέρος για τον αυξημένο καταγματικό κίνδυνο που τη χαρακτηρίζει. Ευρύ παραμένει ακόμα το πεδίο διερεύνησης για τους υπόλοιπους παράγοντες κινδύνου που επηρεάζουν και μεταβάλλουν την οστική κατάσταση (για παράδειγμα ογκομετρική οστική πυκνότητα – vBMD - και γεωμετρία σε σχέση με τη θεραπευτική επιλογή) και επομένως μπορεί να τροποποιούν την καταγματική αντοχή. Σκοπός : Ήταν η εκτίμηση στη μελέτη μας της vBMD και γεωμετρίας της αριστερής κνήμης χρησιμοποιώντας pQCT, καθώς και βιοχημικών παραμέτρων του ΠΥ όπως και η συσχέτιση των δεδομένων μεταξύ τους, συγχρόνως, σε δύο ομάδες μετεμμηνοπαυσιακών ασθενών, που η πρώτη (ομάδα 1) υποβλήθηκε σε εκλεκτική αφαίρεση παραθυροειδών και η δεύτερη (ομάδα 2) έλαβε ριζενδρονάτη προς αντιμετώπιση της νόσου.Υλικό και Μέθοδος : H έναρξη της μελέτης που πραγματοποιήθηκε το 2006, περιλάμβανε τους νεοδιαγνωσθέντες ασθενείς που προσήλθαν για ιατρική βοήθεια στο Εργαστήριο κατά τη διάρκεια ενός έτους. Στο συγκεκριμένο χρονικό διάστημα συνολικά 75 άτομα βρέθηκε να πάσχουν από ΠΥ. 20 αποκλείσθηκαν λόγω λήψης φαρμάκων - διφωσφονικά (15), κορτικοειδή (3), διουρητικά της αγκύλης (2) - και 5 έπασχαν από νόσο του συνδετικού ιστού ενώ 10 ασθενείς δεν έχρηζαν αντιμετώπισης και τέθησαν σε παρακολούθηση. Η απόφαση για την υποβολή των μισών ασθενών σε χειρουργική επέμβαση αφαίρεσης παραθυρεοειδών στηρίχθηκε αυστηρά στα κριτήρια του διεθνές συμποσίου του Εθνικού Ινστιτούτου Υγείας των ΗΠΑ…

Subjects/Keywords: Πρωτοπαθής υπερπαραθυρεοειδισμός; Οστική γεωμετρία; Περιφερική ποσοτική υπολογιστική τομογραφία; Παραθυροειδεκτομή; Ριζενδρονάτη; Primary hyperparathyroidism; Bone geometry; pQCT; Parathyroidectomy; Rizendronate

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Φακιδάρη, . �. (2013). Μεταβολές των γεωμετρικών σκελετικών χαρακτηριστικών σε ασθενείς με πρωτοπαθή υπερπαραθυροειδισμό μετά χειρουργική η συντηρητική αντιμετώπιση. (Thesis). National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ). Retrieved from http://hdl.handle.net/10442/hedi/38547

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Φακιδάρη, Ελένη. “Μεταβολές των γεωμετρικών σκελετικών χαρακτηριστικών σε ασθενείς με πρωτοπαθή υπερπαραθυροειδισμό μετά χειρουργική η συντηρητική αντιμετώπιση.” 2013. Thesis, National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ). Accessed April 12, 2021. http://hdl.handle.net/10442/hedi/38547.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Φακιδάρη, Ελένη. “Μεταβολές των γεωμετρικών σκελετικών χαρακτηριστικών σε ασθενείς με πρωτοπαθή υπερπαραθυροειδισμό μετά χειρουργική η συντηρητική αντιμετώπιση.” 2013. Web. 12 Apr 2021.

Vancouver:

Φακιδάρη �. Μεταβολές των γεωμετρικών σκελετικών χαρακτηριστικών σε ασθενείς με πρωτοπαθή υπερπαραθυροειδισμό μετά χειρουργική η συντηρητική αντιμετώπιση. [Internet] [Thesis]. National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ); 2013. [cited 2021 Apr 12]. Available from: http://hdl.handle.net/10442/hedi/38547.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Φακιδάρη �. Μεταβολές των γεωμετρικών σκελετικών χαρακτηριστικών σε ασθενείς με πρωτοπαθή υπερπαραθυροειδισμό μετά χειρουργική η συντηρητική αντιμετώπιση. [Thesis]. National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ); 2013. Available from: http://hdl.handle.net/10442/hedi/38547

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

29. Choi, Joseph Do Woong. The Parathyroid Glands and Parathyroid Surgery in End Stage Renal Failure .

Degree: 2017, Australian National University

URL: http://hdl.handle.net/1885/146626

► Background Since the 1850s, parathyroid surgery continues to evolve through improved understanding of the pathophysiology. Dialysis dependant end stage renal failure (ESRF), the major cause… (more)

▼ Background Since the 1850s, parathyroid surgery continues to evolve through improved understanding of the pathophysiology. Dialysis dependant end stage renal failure (ESRF), the major cause of secondary hyperparathyroidism continues to rise in the western world. Other than renal transplantation, parathyroidectomy may provide a substantial cure for longstanding renal hyperparathyroidism in dialysis dependant patients. In 2004, cinacalcet was introduced as an alternative to the surgical management of renal hyperparathyroidism. However, cinacalcet was withdrawn from Australia’s Pharmaceutical Benefits Scheme (PBS) in 2015, as the EVOLVE study failed to demonstrate a statistically significant reduction in the time to death, or non-fatal cardiovascular events in those treated with cinacalcet with renal hyperparathyroidism. This led to a re-emergence in parathyroidectomy. Additionally in our institution, patients who had been on cinacalcet, and subsequently underwent parathyroidectomy because of refractory disease or intolerance to cinacalcet, were noted to experience greater hyperkalaemia and hypocalcaemia in the intraoperative and immediate postoperative period. Aims • To review the engrossing history of the discovery and progression of parathyroid surgery since the 19th century; • To correlate the embryology, anatomy, histology, physiology and pathophysiology of parathyroid glands in end stage renal failure; • To provide up to date review in regards to investigation and the surgical management of renal hyperparathyroidism; • Conduct a cohort study on the association of cinacalcet use with greater likelihood of intraoperative and immediate postoperative hyperkalaemia and hypocalcaemia following parathyroidectomy in renal hyperparathyroidism. Methods Literature reviews utilizing MEDLINE and Cochrane review databases, life science journals and textbooks were utilized. Hospital medical records from The Canberra Hospital were studied to collect data on the cohort case series. Analysis of data was performed using SPSS Statistics and Microsoft Excel. Results Sir Richard Owen is reputed to be the first person to discover the existence of parathyroid glands when examining a rhinoceros in 1852. In the spirit of mortui vivos docent, Captain Charles Martell in the 1930s had significantly increased our understanding of the existence of ectopic locations of parathyroid glands, as well as operative planning. The physiology and pathophysiology of parathyroid glands in chronic renal failure is multifaceted, with a complex interplay between bone, kidneys, intestine, vitamin D, potassium, phosphate and magnesium. There are a range of investigative strategies for localizing parathyroid glands, often yielding greater sensitivity and specificity when…

Subjects/Keywords: Parathyroid; Hyperparathyroidism; End Stage Renal Failure; Parathyroidectomy

…renal hyperparathyroidism. Conclusions The continued inquiry into the basic sciences… …around renal hyperparathyroidism ensures that we are able to question traditional protocols… …medical and surgical landscape in the treatment of hyperparathyroidism. The results of the… …hyperparathyroidism in cinacalcet parathyroidectomy. 8 treated patients requiring Table of Contents… …REVEW OF PARATHYROID GLANDS AND HYPERPARATHYROIDISM IN END STAGE RENAL FAILURE Chapter 1…

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Choi, J. D. W. (2017). The Parathyroid Glands and Parathyroid Surgery in End Stage Renal Failure . (Thesis). Australian National University. Retrieved from http://hdl.handle.net/1885/146626

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Choi, Joseph Do Woong. “The Parathyroid Glands and Parathyroid Surgery in End Stage Renal Failure .” 2017. Thesis, Australian National University. Accessed April 12, 2021. http://hdl.handle.net/1885/146626.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Choi, Joseph Do Woong. “The Parathyroid Glands and Parathyroid Surgery in End Stage Renal Failure .” 2017. Web. 12 Apr 2021.

Vancouver:

Choi JDW. The Parathyroid Glands and Parathyroid Surgery in End Stage Renal Failure . [Internet] [Thesis]. Australian National University; 2017. [cited 2021 Apr 12]. Available from: http://hdl.handle.net/1885/146626.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Choi JDW. The Parathyroid Glands and Parathyroid Surgery in End Stage Renal Failure . [Thesis]. Australian National University; 2017. Available from: http://hdl.handle.net/1885/146626

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

30. Smit, Pieter Casper. Image guided, minimally invasive adenomectomy for solitary gland disease in primary hyperparathyroidism.

Degree: 2001, University Utrecht

URL: https://dspace.library.uu.nl/handle/1874/391 ; URN:NBN:NL:UI:10-1874-391 ; 1874/391 ; URN:NBN:NL:UI:10-1874-391 ; https://dspace.library.uu.nl/handle/1874/391

► Introduction: Since the introduction in the 1970s of the unilateral approach in surgery for primary hyperparathyroidism by Wang, authors have increasingly been recommending limited forms… (more)

▼ Introduction: Since the introduction in the 1970s of the unilateral approach in surgery for primary hyperparathyroidism by Wang, authors have increasingly been recommending limited forms of parathyroid surgery. Although unilateral explorations reduce operation time and admission days, decrease operative risk and give better cosmetic results, the debate about the best surgical treatment for primary hyperparathyroidism has never been settled. Bilateralists oppose less invasive approaches because they estimate the incidence of multiple gland disease to be as high as 30%. However, in spite of a systematic bilateral exploration of the neck in search of the diseased parathyroid gland, with identification and estimation of the size of all parathyroid tissue, in only 44% of cases are four glands identified, in 37% three, and in 19% less than three. In chapter 1 we reported an exceptional case of persistent hyperparathyroidism (due to a non-descended inferior parathyroid) after extensive bilateral exploration, illustrating a clinical dilemma that can be encountered in parathyroid surgery. Imaging carried out prior to re-exploration and including, among other methods, ultrasonography and computed tomography, revealed a parathyroid adenoma at the level of the mandibular angle and the hyoid bone. Guided by the imaging results the adenoma was successfully resected by a local direct procedure taking less than 10 minutes. In general, the main reason an adenoma is not found during exploration is the variability in location, rather than variety in the number of glands. It is therefore of pivotal importance to understand not only the anatomy, but also the embryology of the parathyroid glands. As radiologist John Doppman succinctly stated, If you are an experienced parathyroid surgeon and not able to find a tumor, you cannot have looked high enough. Since primary hyperparathyroidism can be diagnosed with nearly 100% accuracy and successfully treated in more than 95% of cases, surgery is the treatment of choice. The gold standard in parathyroid surgery has been conventional neck exploration (CNE), and with success rates exceeding 95% and virtually no complications nothing more seemed left to be desired. However, it cannot be denied that there is a discrepancy between the extent of the operation and the size of the offending gland in the majority of patients. Encouraged by the pace of development in methods of imaging (resulting in increased accuracy), combined with the knowledge that primary hyperparathyroidism is caused by a solitary adenoma in at least 85% of cases, and our experience of the relatively simple and quick MIA procedure (chapter 1) we wondered whether such a direct, minimally invasive strategy could be utilized for the more common cases of primary hyperparathyroidism as well. For this purpose we formulated the following hypothesis (chapter 3): A substantial group of patients with primary hyperparathyroidism can be successfully treated by limited access surgery after preoperative localization studies and may thus be…

Subjects/Keywords: minimally invasive; primary hyperparathyroidism; hyperparathyreoïdie; mia; cne

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APA (6^th Edition):

Smit, P. C. (2001). Image guided, minimally invasive adenomectomy for solitary gland disease in primary hyperparathyroidism. (Doctoral Dissertation). University Utrecht. Retrieved from https://dspace.library.uu.nl/handle/1874/391 ; URN:NBN:NL:UI:10-1874-391 ; 1874/391 ; URN:NBN:NL:UI:10-1874-391 ; https://dspace.library.uu.nl/handle/1874/391

Chicago Manual of Style (16^th Edition):

Smit, Pieter Casper. “Image guided, minimally invasive adenomectomy for solitary gland disease in primary hyperparathyroidism.” 2001. Doctoral Dissertation, University Utrecht. Accessed April 12, 2021. https://dspace.library.uu.nl/handle/1874/391 ; URN:NBN:NL:UI:10-1874-391 ; 1874/391 ; URN:NBN:NL:UI:10-1874-391 ; https://dspace.library.uu.nl/handle/1874/391.

MLA Handbook (7^th Edition):

Smit, Pieter Casper. “Image guided, minimally invasive adenomectomy for solitary gland disease in primary hyperparathyroidism.” 2001. Web. 12 Apr 2021.

Vancouver:

Smit PC. Image guided, minimally invasive adenomectomy for solitary gland disease in primary hyperparathyroidism. [Internet] [Doctoral dissertation]. University Utrecht; 2001. [cited 2021 Apr 12]. Available from: https://dspace.library.uu.nl/handle/1874/391 ; URN:NBN:NL:UI:10-1874-391 ; 1874/391 ; URN:NBN:NL:UI:10-1874-391 ; https://dspace.library.uu.nl/handle/1874/391.

Council of Science Editors:

Smit PC. Image guided, minimally invasive adenomectomy for solitary gland disease in primary hyperparathyroidism. [Doctoral Dissertation]. University Utrecht; 2001. Available from: https://dspace.library.uu.nl/handle/1874/391 ; URN:NBN:NL:UI:10-1874-391 ; 1874/391 ; URN:NBN:NL:UI:10-1874-391 ; https://dspace.library.uu.nl/handle/1874/391

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