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1.
Six, Anne.
Caractérisation moléculaire et fonctionnelle de la protéine Srr2 et rôle dans l’hypervirulence du clone ST-17 de Streptococcus agalactiae : Molecular and functional characterization of Srr2, an ST-17 specific surface protein of Streptococcus agalactiae.
Degree: Docteur es, Microbiologie, 2013, Université Paris Descartes – Paris V
URL: http://www.theses.fr/2013PA05T038 
► Streptococcus agalactiae est la première cause d’infections invasives chez le nouveau né et, malgré la mise en place de stratégies de prévention, cette bactérie reste…
(more)
▼ Streptococcus agalactiae est la première cause d’infections invasives chez le nouveau né et, malgré la mise en place de stratégies de prévention, cette bactérie reste le principal agent étiologique des infections néonatales. Les souches de séquence type 17, dites hyper-virulentes, sont particulièrement associées avec les méningites, type d’infection ayant des conséquences lourdes en terme de mortalité et morbidité. Ce clone possède des caractéristiques uniques, telle que la fixation au fibrinogène, ainsi qu’un répertoire de protéines de surface qui lui sont spécifiques. Parmi ces protéines, Srr2 appartient à une famille de larges glycoprotéines streptococcales et staphylococcales impliquées dans la pathogénicité. Un domaine central de Srr2, le domaine BR, est responsable de la fixation spécifique du fibrinogène par le clone ST-17, ainsi qu’au plasminogène et à divers composants de la matrice extracellulaire. Cette protéine promeut ainsi l’adhésion et le franchissement des barrières cellulaires. L’interaction de Srr2 avec les systèmes fibrinolytique et de coagulation de l’hôte favorise la dissémination bactérienne par l’activation de la fibrinolyse, et la persistance de la bactérie dans l’organisme par la formation d’agrégats bactériens. La liaison de Srr2 avec le fibrinogène semble également promouvoir la persistance bactérienne en favorisant l’internalisation et la survie dans les macrophages. Ainsi, la protéine Srr2 confère un avantage pour le processus infectieux du clone ST-17 dans l’hôte, et constitue une cible vaccinale intéressante pour la prévention des infections à S. agalactiae.
Streptococcus agalactiae is the leading cause of invasive infections in neonates. Despite the implementation of prevention strategies, this bacterium remains the main etiological agent of neonatal infections. Hyper-virulent sequence-type 17 strains are particularly associated with meningitis, a type of infection with serious consequences in terms of mortality and morbidity. This clone has unique characteristics, such as fibrinogen binding, and a panel of specific surface proteins. Among these proteins, Srr2 belongs to a family of large streptococcal and staphylococcal glycoproteins involved in pathogenicity. A central domain of Srr2, BR domain, is responsible for the specific binding of fibrinogen by the ST -17 clone and also binds plasminogen and various components of the extracellular matrix. Thereby, it promotes adhesion and crossing of cellular barriers. The interaction of Srr2 with fibrinolytic and coagulation systems of the host could promote bacterial spread through the activation of fibrinolysis and the persistence of the bacteria in the host by the formation of bacterial aggregates. The interaction of Srr2 with fibrinogen also seems to promote bacterial persistence in promoting the internalization and survival of the bacteria in macrophages. Thus, Srr2 confers an advantage to the infectious process of the ST- 17 clone in the host and is an attractive vaccine candidate for the prevention of S. agalactiae infections.
Advisors/Committee Members: Poyart, Claire (thesis director).
Subjects/Keywords: Streptococcus agalactiae; Complexe clonal hyper-virulent; Protéine de surface; Srr2; Fibrinogène; Dissémination; Persistance; Barrière cellulaire; Virulence; Streptococcus agalactiae; Hyper-virulent clonal complex; Surface protein; Srr2; Fibrinogen; Bacterial spread; Persistence; Cellular barrier; Virulence; 616.904 1
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APA (6th Edition):
Six, A. (2013). Caractérisation moléculaire et fonctionnelle de la protéine Srr2 et rôle dans l’hypervirulence du clone ST-17 de Streptococcus agalactiae : Molecular and functional characterization of Srr2, an ST-17 specific surface protein of Streptococcus agalactiae. (Doctoral Dissertation). Université Paris Descartes – Paris V. Retrieved from http://www.theses.fr/2013PA05T038
Chicago Manual of Style (16th Edition):
Six, Anne. “Caractérisation moléculaire et fonctionnelle de la protéine Srr2 et rôle dans l’hypervirulence du clone ST-17 de Streptococcus agalactiae : Molecular and functional characterization of Srr2, an ST-17 specific surface protein of Streptococcus agalactiae.” 2013. Doctoral Dissertation, Université Paris Descartes – Paris V. Accessed January 16, 2021.
http://www.theses.fr/2013PA05T038.
MLA Handbook (7th Edition):
Six, Anne. “Caractérisation moléculaire et fonctionnelle de la protéine Srr2 et rôle dans l’hypervirulence du clone ST-17 de Streptococcus agalactiae : Molecular and functional characterization of Srr2, an ST-17 specific surface protein of Streptococcus agalactiae.” 2013. Web. 16 Jan 2021.
Vancouver:
Six A. Caractérisation moléculaire et fonctionnelle de la protéine Srr2 et rôle dans l’hypervirulence du clone ST-17 de Streptococcus agalactiae : Molecular and functional characterization of Srr2, an ST-17 specific surface protein of Streptococcus agalactiae. [Internet] [Doctoral dissertation]. Université Paris Descartes – Paris V; 2013. [cited 2021 Jan 16].
Available from: http://www.theses.fr/2013PA05T038.
Council of Science Editors:
Six A. Caractérisation moléculaire et fonctionnelle de la protéine Srr2 et rôle dans l’hypervirulence du clone ST-17 de Streptococcus agalactiae : Molecular and functional characterization of Srr2, an ST-17 specific surface protein of Streptococcus agalactiae. [Doctoral Dissertation]. Université Paris Descartes – Paris V; 2013. Available from: http://www.theses.fr/2013PA05T038
University of the Western Cape
2.
Naidu, Alecia Geraldine.
Computational characterisation of DNA methylomes in mycobacterium tuberculosis Beijing hyper- and hypo-virulent strains
.
Degree: 2014, University of the Western Cape
URL: http://hdl.handle.net/11394/4756
► Mycobacterium tuberculosis, the causative agent of tuberculosis, is estimated to infect approximately one-third of the world’s population and is responsible for around 2 million deaths…
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▼ Mycobacterium tuberculosis, the causative agent of tuberculosis, is estimated to infect approximately one-third of the world’s population and is responsible for around 2 million deaths per year. The disease is endemic in South Africa which has one of the world’s highest tuberculosis incidence and death rates. The M. tuberculosis Beijing genotype are characterised by having an enhanced virulence capability over other M. tuberculosis strains and are the predominant strain observed in the Western Cape of South Africa. DNA methylation is a largely untapped area of research in M.tuberculosis and has been poorly described in the literature especially given its connection to virulence despite it being well characterised along with its role in virulence in other pathogenic bacteria such as E.coli. The overall aim was to characterise a global DNA methylation profile for two M. tuberculosis Beijing strains,
hyper-
virulent and hypo-
virulent, using single molecule real time sequencing data technology. Moreover, to determine if adenine methylation in promoter regions has a possible functional role. This study identified and characterised the DNA methylation profile at the single nucleotide resolution in these strains using Pacific Biosciences single molecule real time sequencing data. A computational approach was used to discern DNA methylation patterns between the
hyper and hypo-
virulent strains with a view of understanding virulence in the
hyper-
virulent strain. Methylated motifs, which belong to known Restriction Modification (RM) systems of the H37Rv referencegenome were also identified. N6-methyladenine (m6A) and N4-methlycytosine (m4C) loci were identified in both strains. m6A were idenitified in both strains occuring within the following sequence motifs CACGCAG (Type II RM system), GATNNNNRTAC/GTAYNNNNATC (Type I RM system), while the CTGGAGGA motif was found to be uniquley methylated in the
hyper-virulentstrain.Interestingly, the CACGCAG motif was significantly methylated (p = 9.9 x10 -63) at a higher proportion in intergenic regions (~70%) as opposed to genic regions in both the
hyper-
virulent and hypo-
virulent strains suggesting a role in gene regulation. There appeared to be a higher proportion of m6A occuring in intergenic regions compared to within genes for
hyper-
virulent (61%) and hypo-
virulent (62%) strains. The genic proportion revealed that 35% of total m6A occurred uniquely within genes for the
hyper-
virulent strain while 27.9% for uniquely methylated genes in hypo-
virulent strain.
Advisors/Committee Members: Christoffels, Alan (advisor), Gey van Pittius, Nico (advisor).
Subjects/Keywords: DNA methylation;
Methyltransferase;
Hyper-virulent strain;
Next generation sequencing;
Mycobacterium tuberculosis
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APA (6th Edition):
Naidu, A. G. (2014). Computational characterisation of DNA methylomes in mycobacterium tuberculosis Beijing hyper- and hypo-virulent strains
. (Thesis). University of the Western Cape. Retrieved from http://hdl.handle.net/11394/4756
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Naidu, Alecia Geraldine. “Computational characterisation of DNA methylomes in mycobacterium tuberculosis Beijing hyper- and hypo-virulent strains
.” 2014. Thesis, University of the Western Cape. Accessed January 16, 2021.
http://hdl.handle.net/11394/4756.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Naidu, Alecia Geraldine. “Computational characterisation of DNA methylomes in mycobacterium tuberculosis Beijing hyper- and hypo-virulent strains
.” 2014. Web. 16 Jan 2021.
Vancouver:
Naidu AG. Computational characterisation of DNA methylomes in mycobacterium tuberculosis Beijing hyper- and hypo-virulent strains
. [Internet] [Thesis]. University of the Western Cape; 2014. [cited 2021 Jan 16].
Available from: http://hdl.handle.net/11394/4756.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Naidu AG. Computational characterisation of DNA methylomes in mycobacterium tuberculosis Beijing hyper- and hypo-virulent strains
. [Thesis]. University of the Western Cape; 2014. Available from: http://hdl.handle.net/11394/4756
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Gothenburg / Göteborgs Universitet
3.
Backhaus, Erik.
Invasive Pneumococcal Infections.
Degree: 2011, University of Gothenburg / Göteborgs Universitet
URL: http://hdl.handle.net/2077/27821
► Streptococcus pneumoniae is a major cause of disease, ranging from uncomplicated respiratory infections to severe invasive pneumococcal disease (IPD), including bacteraemic pneumonia, septicaemia with unknown…
(more)
▼ Streptococcus pneumoniae is a major cause of disease, ranging from uncomplicated respiratory
infections to severe invasive pneumococcal disease (IPD), including bacteraemic pneumonia,
septicaemia with unknown focus and meningitis. Case fatality rate (CFR) remains high and antibiotic
resistance is increasing globally. S. pneumoniae is surrounded by a polysaccharide capsule that can be
divided into more than 90 immunologically different serotypes. Vaccination may reduce morbidity
and mortality due to IPD. Two vaccine types exist: pneumococcal polysaccharide vaccine (PPV-23)
and pneumococcal conjugate vaccines (PCV-7, 10, 13). The former contains 23 serotypes, but does
not work in small children, whereas the latter also protects children below two years of age, but
includes only 7, 10 and 13 serotypes, respectively.
The aim was to explore the epidemiology of IPD before the introduction of PCV-7 in the Swedish
childhood vaccination programme, in January 2009: serotype distribution, antimicrobial susceptibility
and potential vaccine coverage among isolates causing IPD; mortality, case fatality rate and incidence
of different IPD manifestations related to age and risk groups; the impact of serotype and genotype on
manifestations and outcome; and finally, long-term changes in the epidemiology during 45 years.
Consecutive isolates and clinical data from 836 adults and children with IPD were collected in the
Västra Götaland region (VGR) and Halland during 1998-2001. Serotype and antibiotic susceptibility
were tested. Clonal complex (CC) was determined for these isolates together with 424 IPD isolates
from adults and children in Stockholm using pulsed field gel electrophoresis (PFGE) and multi-locus
sequence typing (MLST). Clinical data for all 2977 IPD episodes in VGR during 1996-2008 were
retrieved from hospital notes. Prevalence data for predisposing factors were included from patient
registries and recent publications.
Of 836 strains, 42%, 70%, 75% and 94% belonged to serotypes included in PCV-7, -10, -13 and PPV-
23, respectively. Decreased susceptibility was uncommon, and largely confined to certain clones and
serotypes, especially those included in PCV-7. Serotypes 1 and 7F were most common; they infected
younger patients with less underlying disease and caused lower CFR than other serotypes, whereas
19A caused higher CFR. Clonal distribution differed between adults and children. CC306 (all serotype
1), caused lower CFR among adults than six other CCs. The relation between serotype and CC was
complicated; clinical characteristics differed between some CCs within the same serotype and between
some serotypes within the same CC; it was often difficult to determine whether these differences were
related to serotype, CC or both.
The annual incidence of IPD was 15/100,000 and varied largely with age and underlying disease. It
was highest at extremes of age and in patients with myeloma (2238/100,000), followed by chronic
lymphatic leukemia, haemodialysis, lung cancer, HIV, rheumatic diseases, chronic obstructive
pulmonary…
Subjects/Keywords: Streptococcus pneumoniae; epidemiology; risk factors; pneumonia; meningitis; serotype; clonal complex
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APA ·
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APA (6th Edition):
Backhaus, E. (2011). Invasive Pneumococcal Infections. (Thesis). University of Gothenburg / Göteborgs Universitet. Retrieved from http://hdl.handle.net/2077/27821
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Backhaus, Erik. “Invasive Pneumococcal Infections.” 2011. Thesis, University of Gothenburg / Göteborgs Universitet. Accessed January 16, 2021.
http://hdl.handle.net/2077/27821.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Backhaus, Erik. “Invasive Pneumococcal Infections.” 2011. Web. 16 Jan 2021.
Vancouver:
Backhaus E. Invasive Pneumococcal Infections. [Internet] [Thesis]. University of Gothenburg / Göteborgs Universitet; 2011. [cited 2021 Jan 16].
Available from: http://hdl.handle.net/2077/27821.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Backhaus E. Invasive Pneumococcal Infections. [Thesis]. University of Gothenburg / Göteborgs Universitet; 2011. Available from: http://hdl.handle.net/2077/27821
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
4.
Kruy, Sun Lay.
Diversité phénotypique et génotypique de salmonelles isolées au Cambodge à partir d’échantillons biologiques alimentaires ou humains : Phenotypic and genotypic diversity of salmonella isolated in Cambodia from food or human biological specimens.
Degree: Docteur es, Sciences, technologie, santé. Génétique, 2011, Université de Bordeaux Segalen
URL: http://www.theses.fr/2011BOR21809
► Salmonella (S.) enterica est reconnue comme le principal agent causal de la salmonellose chez l’homme et les animaux. La distribution épidémiologique de cette infection implique…
(more)
▼ Salmonella (S.) enterica est reconnue comme le principal agent causal de la salmonellose chez l’homme et les animaux. La distribution épidémiologique de cette infection implique souvent des régions géographiques éloignées; il est ainsi nécessaire de posséder des méthodes fiables afin de pouvoir discriminer des souches responsables d’une épidémie. En raison des limites de la méthode de typage sérologique, de nombreuses méthodes de génotypage moléculaire ont été développées. En particulier, la méthode par PCR couplée à l’électrophorèse en champ pulsé, qui est utilisée pour la séparation et la caractérisation des molécules d’ADN, et le génotypage par analyse de répétition en tandem polymorphe ou MLVA (Multiple-Locus VNTR Analysis), sont des méthodes modernes qui permettent d’étudier le polymorphisme et la diversité génétique des souches de S. enterica liées à une épidémie. Dans notre étude, onze marqueurs contenant des régions de répétitions en tandem polymorphique (VNTR : Variable Number Tandem Repeats) sélectionnés à partir du génome de S. enterica Typhimurium LT2 ont été utilisés pour évaluer la diversité génétique de 206 souches de S. enterica sélectionnées entre 2001 et 2007. Ces salmonelles sont représentées par 31 sérotypes, ont été isolées à partir de trois sources: hommes, aliments cuits et crus. Chaque souche a été isolée à partir d’échantillon unique et n’était liée à aucun épisode d’intoxication alimentaire ou à une épidémie de salmonellose connue. La technique MLVA a permis de sous typer 107 génotypes regroupés dans un dendrogramme en deux branches distintes dont la première et constituée par Salmonella Typhi et la deuxième par les 30 autres sérotypes liés entre eux par un ancêtre commun. Parmi les sérotypes, quatre ont été répartis dans deux à cinq branches phylogénétiques. La représentation de la variation allélique des sérotypes de S. enterica a utilisé l’arbre minimum couvrant sans racine. Des variations alléliques pour des sérotypes de S. enterica précédemment ou nouvellement décrits ont été identifiées et des variants génétiques ont été répartis en types ou en variants MLVA à loci uniques, en variants différents par un locus (SLVs), en variants différant par deux loci (DLVs) et des variants différant par plus de deux loci. Quatre marqueurs (STTR3, STTR5, STTR8 et Sal20) ont présenté un indice de diversité élevé (DI> 0,80). En résumé, la technique MLVA peut être appliquée pour étudier le profil génétique de S. enterica avec une grande diversité de sérotypes.
Epidemiological distribution of this infection often involves large areas of geographically distant, and reliable methods to discriminate strains responsible for an epidemic are necessary. Due to limitations of serological typing method, many molecular genotyping methods have been developed. Some molecular methods and their applications are: PCR coupled to PFGE, which is used for the separation and characterization of molecular profiles, and MLVA (Multiple-Locus VNTR Analysis) genotyping, or so called analysis of polymorphic tandem repeats are…
Advisors/Committee Members: Koeck, Jean-Louis (thesis director).
Subjects/Keywords: MLVA; VNTR; Salmonelles; Échantillons biologiques humains; Échantillons biologiques alimentaires cuits et crus; Complexe clonal; MLVA; VNTR; Salmonella; Human and food biological samples; Clonal complex
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APA ·
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APA (6th Edition):
Kruy, S. L. (2011). Diversité phénotypique et génotypique de salmonelles isolées au Cambodge à partir d’échantillons biologiques alimentaires ou humains : Phenotypic and genotypic diversity of salmonella isolated in Cambodia from food or human biological specimens. (Doctoral Dissertation). Université de Bordeaux Segalen. Retrieved from http://www.theses.fr/2011BOR21809
Chicago Manual of Style (16th Edition):
Kruy, Sun Lay. “Diversité phénotypique et génotypique de salmonelles isolées au Cambodge à partir d’échantillons biologiques alimentaires ou humains : Phenotypic and genotypic diversity of salmonella isolated in Cambodia from food or human biological specimens.” 2011. Doctoral Dissertation, Université de Bordeaux Segalen. Accessed January 16, 2021.
http://www.theses.fr/2011BOR21809.
MLA Handbook (7th Edition):
Kruy, Sun Lay. “Diversité phénotypique et génotypique de salmonelles isolées au Cambodge à partir d’échantillons biologiques alimentaires ou humains : Phenotypic and genotypic diversity of salmonella isolated in Cambodia from food or human biological specimens.” 2011. Web. 16 Jan 2021.
Vancouver:
Kruy SL. Diversité phénotypique et génotypique de salmonelles isolées au Cambodge à partir d’échantillons biologiques alimentaires ou humains : Phenotypic and genotypic diversity of salmonella isolated in Cambodia from food or human biological specimens. [Internet] [Doctoral dissertation]. Université de Bordeaux Segalen; 2011. [cited 2021 Jan 16].
Available from: http://www.theses.fr/2011BOR21809.
Council of Science Editors:
Kruy SL. Diversité phénotypique et génotypique de salmonelles isolées au Cambodge à partir d’échantillons biologiques alimentaires ou humains : Phenotypic and genotypic diversity of salmonella isolated in Cambodia from food or human biological specimens. [Doctoral Dissertation]. Université de Bordeaux Segalen; 2011. Available from: http://www.theses.fr/2011BOR21809
Universiteit Utrecht
5.
Top, J.
Molecular epidemiology of Enterococcus faecium: from commensal to hospital adapted pathogen.
Degree: 2007, Universiteit Utrecht
URL: http://dspace.library.uu.nl:8080/handle/1874/21193
► For many years Enterococcus faecium was considered a commensal of the digestive tract, which only sporadically caused opportunistic infections in severely ill patients. Over the…
(more)
▼ For many years Enterococcus faecium was considered a commensal of the digestive tract, which only sporadically caused opportunistic infections in severely ill patients. Over the last two decades, vancomycin resistant E. faecium (VREF) has emerged worldwide as an important cause of nosocomial infections, especially in immunocompromised patients. The global VRE epidemic was preceded by the emergence of ampicillin resistant E. faecium (AREfm) in the United States in the early 1980s. Molecular epidemiological studies of both human- and animal-derived E. faecium isolates using multilocus sequence typing (MLST) revealed the existence of host specific genogroups, including a specific genetic lineage associated with hospital related isolates. These strains were characterized by ampicillin and quinolone resistance. In addition, the presence of the variant esp gene was strongly associated with these outbreak strains. In E. faecalis, esp is contained on a so-called pathogenicity island (PAI) and is considered a putative virulence factor. This thesis describes the development of a rapid and cheap identification scheme for enterococci, which is a prerequisite to take appropriate infection control measures. Furthermore, a rapid molecular typing scheme designated multiple locus variable number tandem repeat analysis (MLVA) has been developed to determine genetic relatedness of E. faecium isolates. Clustering of MLVA profiles confirmed the host-specific genogroups found by MLST, including the hospital specific genetic lineage. Comparison of MLVA with Pulsed Field Gel Electrophoresis (PFGE), considered the “gold standard” typing method for infection control programs in hospitals, revealed that both methods were highly concordant in assigning genotypes and comparable in costs. PFGE revealed a higher discriminatory power, but MLVA was faster. Analysis of the up- and downstream regions of the esp gene among several isolates demonstrated that, like in E. faecalis, esp of E. faecium is contained on a putative pathogenicity island (PAI) with remarkable sequence heterogeneity including insertions, deletions and mutations. The E. faecium PAI has, so far, only been detected in outbreak related and clinical isolates, suggesting a role in nosocomial epidemicity. The population structure of E. faecium was elucidated with MLST and the existence of a distinct clonal complex, designated clonal complex-17 (CC17), associated with the majority of hospital outbreaks and clinical infections in five continents, was documented. This complex is correlated with ampicillin and quinolone resistance and the presence of the PAI. A retrospective study in the UMCU revealed ecological replacement of E. faecalis by CC17 E. faecium, illustrated by a decrease in total numbers of invasive enterococcal infections but an increase in proportions of invasive AREfm. Furthermore, the ratio E. faecium/E. faecalis among bloodstream isolates changed in favor of E. faecium. A similar increase of invasive AREfm was observed in hospitals dispersed over the Netherlands, although…
Subjects/Keywords: Geneeskunde; Enterococcus faecium; Multiresistant; Ampicillin resistance; Epidemiology; Molecular typing; MLST; Clonal complex-17; MLVA; Pathogenicity island; Enterococcal surface protein (Esp)
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APA ·
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APA (6th Edition):
Top, J. (2007). Molecular epidemiology of Enterococcus faecium: from commensal to hospital adapted pathogen. (Doctoral Dissertation). Universiteit Utrecht. Retrieved from http://dspace.library.uu.nl:8080/handle/1874/21193
Chicago Manual of Style (16th Edition):
Top, J. “Molecular epidemiology of Enterococcus faecium: from commensal to hospital adapted pathogen.” 2007. Doctoral Dissertation, Universiteit Utrecht. Accessed January 16, 2021.
http://dspace.library.uu.nl:8080/handle/1874/21193.
MLA Handbook (7th Edition):
Top, J. “Molecular epidemiology of Enterococcus faecium: from commensal to hospital adapted pathogen.” 2007. Web. 16 Jan 2021.
Vancouver:
Top J. Molecular epidemiology of Enterococcus faecium: from commensal to hospital adapted pathogen. [Internet] [Doctoral dissertation]. Universiteit Utrecht; 2007. [cited 2021 Jan 16].
Available from: http://dspace.library.uu.nl:8080/handle/1874/21193.
Council of Science Editors:
Top J. Molecular epidemiology of Enterococcus faecium: from commensal to hospital adapted pathogen. [Doctoral Dissertation]. Universiteit Utrecht; 2007. Available from: http://dspace.library.uu.nl:8080/handle/1874/21193
6.
Angely, Christelle.
Propriétés mécaniques et fonctionnelles des cellules épithéliales respiratoires exposées à une toxine bactérienne : l’adénylate cyclase : Mechanical and functionnal properties of respiratory epithelial cells exposed to a bacterial toxine : the adenylate cyclase.
Degree: Docteur es, Biologie cellulaire et moléculaire, 2018, Université Paris-Est
URL: http://www.theses.fr/2018PESC0058
► La recrudescence des infections respiratoires impliquant des facteurs virulents d’origine bactérienne est devenue un problème majeur de santé publique. Mieux caractériser la réponse des cellules…
(more)
▼ La recrudescence des infections respiratoires impliquant des facteurs virulents d’origine bactérienne est devenue un problème majeur de santé publique. Mieux caractériser la réponse des cellules respiratoires dans la phase initiale d’exposition à des toxines bactériennes est important sur les plans physiopathologiques et thérapeutiques. Le but de ce travail est de décrypter les mécanismes cellulaires et moléculaires impliqués lors de l’exposition des cellules épithéliales respiratoires à l’adénylate cyclase (CyaA), une toxine produite par Bordetella pertussis, l’agent responsable de la coqueluche. CyaA a été choisie car elle dispose de multiples moyens qui lui permettent d’envahir un grand nombre de cellules eucaryotes. Elle est notamment capable de transloquer son domaine catalytique directement dans la cellule cible puis d’utiliser la calmoduline endogène pour augmenter le taux d’AMPc à des niveaux supraphysiologiques. Cependant l’effet de ces changements sur la signalisation mécano-chimique (mécanotransduction) a été très peu décrit alors qu’elle affecte les fonctions et l’intégrité cellulaires. Nous proposons donc d’évaluer les fonctions cellulaires et les propriétés mécaniques et d’adhésion des cellules épithéliales respiratoires exposées à CyaA dans le but de déceler des modifications fondamentales dans les processus de mécanotransduction.Nous avons tout d’abord mené une étude préliminaire visant à définir les concentrations physiopathologiques de CyaA utilisées dans nos expériences. Nous avons ainsi déterminé le degré de viabilité cellulaire en fonction de 3 concentrations de CyaA (0.5 ; 5 ; 10 nM), ce qui a montré que la concentration 0.5 nM n’affectait pas la viabilité cellulaire tout en induisant des niveaux supraphysiologiques d’AMPc en moins d’une heure.Nous avons ensuite cherché à évaluer les effets de CyaA sur la migration et la réparation cellulaires, le battement ciliaire et la perméabilité cellulaire de cellules épithéliales représentatives des différents niveaux de l’arbre aérien. CyaA induit une diminution de la migration et de la réparation cellulaires, ainsi qu’une augmentation de la perméabilité cellulaire traduisant un affaiblissement des jonctions latérales.Une étude en immunoflorescence a ensuite été conduite sur les structures intracellulaires et interfaciales des cellules épithéliales alvéolaires exposées aux 3 concentrations de CyaA. Cette étude a montré que CyaA est capable d’induire un remodelage du cytosquelette d’actine ainsi qu’une diminution du nombre des adhérences focales. Enfin, une analyse complète des propriétés mécaniques et des paramètres d’adhésion a été conduite sur les mêmes cellules au moyen de 2 techniques de micro/nanomanipulation revisitées pour permettre à la fois l’évaluation des liens multiples et de la rigidité cellulaire (Microscopie à Force Atomique (AFM) avec indentation et Magnétocytométrie (MTC)). Pour évaluer le rôle de l’AMPc sur les changements observés, les cellules épithéliales respiratoires ont été testées avec la forme active de CyaA et la forme…
Advisors/Committee Members: Isabey, Daniel (thesis director), Planus, Emmanuelle (thesis director).
Subjects/Keywords: Biomécanique; Épithélium respiratoire; Facteur virulent; Bimechanical; Respiratory epithelium; Virulent factor; 616.2
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APA ·
Chicago ·
MLA ·
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CSE |
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APA (6th Edition):
Angely, C. (2018). Propriétés mécaniques et fonctionnelles des cellules épithéliales respiratoires exposées à une toxine bactérienne : l’adénylate cyclase : Mechanical and functionnal properties of respiratory epithelial cells exposed to a bacterial toxine : the adenylate cyclase. (Doctoral Dissertation). Université Paris-Est. Retrieved from http://www.theses.fr/2018PESC0058
Chicago Manual of Style (16th Edition):
Angely, Christelle. “Propriétés mécaniques et fonctionnelles des cellules épithéliales respiratoires exposées à une toxine bactérienne : l’adénylate cyclase : Mechanical and functionnal properties of respiratory epithelial cells exposed to a bacterial toxine : the adenylate cyclase.” 2018. Doctoral Dissertation, Université Paris-Est. Accessed January 16, 2021.
http://www.theses.fr/2018PESC0058.
MLA Handbook (7th Edition):
Angely, Christelle. “Propriétés mécaniques et fonctionnelles des cellules épithéliales respiratoires exposées à une toxine bactérienne : l’adénylate cyclase : Mechanical and functionnal properties of respiratory epithelial cells exposed to a bacterial toxine : the adenylate cyclase.” 2018. Web. 16 Jan 2021.
Vancouver:
Angely C. Propriétés mécaniques et fonctionnelles des cellules épithéliales respiratoires exposées à une toxine bactérienne : l’adénylate cyclase : Mechanical and functionnal properties of respiratory epithelial cells exposed to a bacterial toxine : the adenylate cyclase. [Internet] [Doctoral dissertation]. Université Paris-Est; 2018. [cited 2021 Jan 16].
Available from: http://www.theses.fr/2018PESC0058.
Council of Science Editors:
Angely C. Propriétés mécaniques et fonctionnelles des cellules épithéliales respiratoires exposées à une toxine bactérienne : l’adénylate cyclase : Mechanical and functionnal properties of respiratory epithelial cells exposed to a bacterial toxine : the adenylate cyclase. [Doctoral Dissertation]. Université Paris-Est; 2018. Available from: http://www.theses.fr/2018PESC0058
University of Adelaide
7.
Al Mosallam, Mobarak S.
Clonal integration in Ochthochloa compressa under extreme environmental conditions.
Degree: 2018, University of Adelaide
URL: http://hdl.handle.net/2440/113114
► While multiple studies have indicated the benefit of clonal integration and its role in resisting harsh environmental conditions, many researchers have indicated the need for…
(more)
▼ While multiple studies have indicated the benefit of
clonal integration and its role in resisting harsh environmental conditions, many researchers have indicated the need for further studies to understand fully the role of
clonal integration and what determines the optimal strategies in various environments. In this project a series of studies were carried out in an extremely arid area (Al Thumam area in the Arabian Peninsula) to contribute to the knowledge of the benefits of
clonal integration and understanding the behaviour of the
clonal grass Ochthochloa compressa. This study is unique because it has investigated the benefits of clonality in one of the harshest environments where
clonal plants are found.
Experiment 1. I aimed to understand the patterns of spread and expansion of stolons, particularly whether stolons grew in random directions or are directed to better patches by the mother ramets to establish new daughter ramets maximizing their chances of success. I measured nutrient contents (N, P and K) in patches where mother plants grew, and where daughter ramets had established. In addition, I sampled nearby unoccupied patches. Mother plants were found in patches with higher N concentrations than where the daughter ramets were found. There were no differences in concentration of P; while K was the lowest where not fully rooted daughters were found. The results suggest that daughter ramets did not establish in the best areas, indicating that the spread and expansion of stolons in the O. compressa occurs randomly.
Experiment 2. I investigated the effects of the addition of fertilizer to mother and daughter ramets, including addition of nutrients to daughters disconnected from the mother ramets. Cutting the stolons caused to death of the daughter because these ramets were still dependent on the mother ramets. When connected, mothers that received nutrients affected some transference nutrients to daughter ramets. In contrast, the daughters accumulated the nutrients in above ground tissue when receiving added fertilizer, and there was no sign of transference to the mother ramet. Nutrient addition did not affect in any case the efficiency photosynthetic in both mother and daughter ramets.
Experiment 3. In this experiment, I focused on the effect of the distance between mother and daughter ramets on the performance of daughter ramets. Daughters located close to the mother ramets could suffer competition by the mother if they are within the area of the root system. The results showed no significant differences between mother and daughter ramets in the concentration of nitrogen, phosphorus, and potassium nor in photosynthetic activity. This indicates that the daughters have the ability to resist competition through continued support from their mothers despite the scarcity of resources and the harsh environmental conditions in the study area.
Experiment 4. In this experiment, I studied the effect of simulated grazing on both mother and daughter ramets when one of them was clipped and 50-60% of the leaves were…
Advisors/Committee Members: Facelli, Jose Maria (advisor), Conran, John Godfrey (advisor), School of Biological Sciences (school).
Subjects/Keywords: Clonal integration
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APA ·
Chicago ·
MLA ·
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CSE |
Export
to Zotero / EndNote / Reference
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APA (6th Edition):
Al Mosallam, M. S. (2018). Clonal integration in Ochthochloa compressa under extreme environmental conditions. (Thesis). University of Adelaide. Retrieved from http://hdl.handle.net/2440/113114
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Al Mosallam, Mobarak S. “Clonal integration in Ochthochloa compressa under extreme environmental conditions.” 2018. Thesis, University of Adelaide. Accessed January 16, 2021.
http://hdl.handle.net/2440/113114.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Al Mosallam, Mobarak S. “Clonal integration in Ochthochloa compressa under extreme environmental conditions.” 2018. Web. 16 Jan 2021.
Vancouver:
Al Mosallam MS. Clonal integration in Ochthochloa compressa under extreme environmental conditions. [Internet] [Thesis]. University of Adelaide; 2018. [cited 2021 Jan 16].
Available from: http://hdl.handle.net/2440/113114.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Al Mosallam MS. Clonal integration in Ochthochloa compressa under extreme environmental conditions. [Thesis]. University of Adelaide; 2018. Available from: http://hdl.handle.net/2440/113114
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Pretoria
8.
[No author].
A local network neighbourhood artificial immune
system
.
Degree: 2011, University of Pretoria
URL: http://upetd.up.ac.za/thesis/available/etd-10172011-211435/
► As information is becoming more available online and will forevermore be part of any business, the true value of the large amounts of stored data…
(more)
▼ As information is becoming more available online and
will forevermore be part of any business, the true value of the
large amounts of stored data is in the discovery of hidden and
unknown relations and connections or traits in the data. The
acquisition of these hidden relations can influence strategic
decisions which have an impact on the success of a business. Data
clustering is one of many methods to partition data into different
groups in such a way that data patterns within the same group share
some common trait compared to patterns across different groups.
This thesis proposes a new artificial immune model for the problem
of data clustering. The new model is inspired by the network theory
of immunology and differs from its network based predecessor models
in its formation of artificial lymphocyte networks. The proposed
model is first applied to data clustering problems in stationary
environments. Two different techniques are then proposed which
enhances the proposed artificial immune model to dynamically
determine the number of clusters in a data set with minimal to no
user interference. A technique to generate synthetic data sets for
data clustering of non-stationary environments is then proposed.
Lastly, the original proposed artificial immune model and the
enhanced version to dynamically determine the number of clusters
are then applied to generated synthetic non-stationary data
clustering problems. The influence of the parameters on the
clustering performance is investigated for all versions of the
proposed artificial immune model and supported by empirical results
and statistical hypothesis tests. AFRIKAANS: Soos wat inligting
meer aanlyn toeganglik raak en vir altyd meer deel vorm van enige
besigheid, is die eintlike waarde van groot hoeveelhede data in die
ontdekking van verskuilde en onbekende verwantskappe en konneksies
of eienskappe in die data. Die verkryging van sulke verskuilde
verwantskappe kan die strategiese besluitneming van ’n besigheid
beinvloed, wat weer ’n impak het op die sukses van ’n besigheid.
Data groepering is een van baie metodes om data op so ’n manier te
groepeer dat data patrone wat deel vorm van dieselfde groep ’n
gemeenskaplike eienskap deel in vergelyking met patrone wat
verspreid is in ander groepe. Hierdie tesis stel ’n nuwe kunsmatige
immuun model voor vir die probleem van data groepering. Die nuwe
model is geinspireer deur die netwerk teorie in immunologie en
verskil van vorige netwerk gebaseerde modelle deur die model se
formasie van kunsmatige limfosiet netwerke. Die voorgestelde model
word eers toegepas op data groeperingsprobleme in statiese
omgewings. Twee verskillende tegnieke word dan voorgestel wat die
voorgestelde kunsmatige immuun model op so ’n manier verbeter dat
die model die aantal groepe in ’n data stel dinamies kan bepaal met
minimum tot geen gebruiker invloed. ’n Tegniek om kunsmatige data
stelle te genereer vir data groepering in dinamiese omgewings word
dan voorgestel. Laastens word die oorspronklik voorgestelde model
sowel as die verbeterde model wat…
Advisors/Committee Members: Engelbrecht, Andries P (advisor).
Subjects/Keywords: Klonale seleksie;
Kunsmatige immuun netwerke;
Immuun netwerk topologieë;
Groepering van dinamiese data;
Affiniteit volwassewording;
Somatiese hiper mutasie;
Kunsmatige limfosiete;
Data groepering;
Affinity maturation;
Clonal selection;
Artificial lymphocytes;
Somatic hyper mutation;
Groepering prestasie maatreëls;
Data clustering;
Dinamiese groepering;
UCTD
Record Details
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Record Details
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
author], [. (2011). A local network neighbourhood artificial immune
system
. (Doctoral Dissertation). University of Pretoria. Retrieved from http://upetd.up.ac.za/thesis/available/etd-10172011-211435/
Chicago Manual of Style (16th Edition):
author], [No. “A local network neighbourhood artificial immune
system
.” 2011. Doctoral Dissertation, University of Pretoria. Accessed January 16, 2021.
http://upetd.up.ac.za/thesis/available/etd-10172011-211435/.
MLA Handbook (7th Edition):
author], [No. “A local network neighbourhood artificial immune
system
.” 2011. Web. 16 Jan 2021.
Vancouver:
author] [. A local network neighbourhood artificial immune
system
. [Internet] [Doctoral dissertation]. University of Pretoria; 2011. [cited 2021 Jan 16].
Available from: http://upetd.up.ac.za/thesis/available/etd-10172011-211435/.
Council of Science Editors:
author] [. A local network neighbourhood artificial immune
system
. [Doctoral Dissertation]. University of Pretoria; 2011. Available from: http://upetd.up.ac.za/thesis/available/etd-10172011-211435/
University of Pretoria
9.
Graaff, A.J. (Alexander
Jakobus).
A local network
neighbourhood artificial immune system.
Degree: Computer Science, 2011, University of Pretoria
URL: http://hdl.handle.net/2263/28799
► As information is becoming more available online and will forevermore be part of any business, the true value of the large amounts of stored data…
(more)
▼ As information is becoming more available online and will
forevermore be part of any business, the true value of the large
amounts of stored data is in the discovery of hidden and unknown
relations and connections or traits in the data. The acquisition of
these hidden relations can influence strategic decisions which have
an impact on the success of a business. Data clustering is one of
many methods to partition data into different groups in such a way
that data patterns within the same group share some common trait
compared to patterns across different groups. This thesis proposes
a new artificial immune model for the problem of data clustering.
The new model is inspired by the network theory of immunology and
differs from its network based predecessor models in its formation
of artificial lymphocyte networks. The proposed model is first
applied to data clustering problems in stationary environments. Two
different techniques are then proposed which enhances the proposed
artificial immune model to dynamically determine the number of
clusters in a data set with minimal to no user interference. A
technique to generate synthetic data sets for data clustering of
non-stationary environments is then proposed. Lastly, the original
proposed artificial immune model and the enhanced version to
dynamically determine the number of clusters are then applied to
generated synthetic non-stationary data clustering problems. The
influence of the parameters on the clustering performance is
investigated for all versions of the proposed artificial immune
model and supported by empirical results and statistical hypothesis
tests. AFRIKAANS: Soos wat inligting meer aanlyn toeganglik raak en
vir altyd meer deel vorm van enige besigheid, is die eintlike
waarde van groot hoeveelhede data in die ontdekking van verskuilde
en onbekende verwantskappe en konneksies of eienskappe in die data.
Die verkryging van sulke verskuilde verwantskappe kan die
strategiese besluitneming van ’n besigheid beinvloed, wat weer ’n
impak het op die sukses van ’n besigheid. Data groepering is een
van baie metodes om data op so ’n manier te groepeer dat data
patrone wat deel vorm van dieselfde groep ’n gemeenskaplike
eienskap deel in vergelyking met patrone wat verspreid is in ander
groepe. Hierdie tesis stel ’n nuwe kunsmatige immuun model voor vir
die probleem van data groepering. Die nuwe model is geinspireer
deur die netwerk teorie in immunologie en verskil van vorige
netwerk gebaseerde modelle deur die model se formasie van
kunsmatige limfosiet netwerke. Die voorgestelde model word eers
toegepas op data groeperingsprobleme in statiese omgewings. Twee
verskillende tegnieke word dan voorgestel wat die voorgestelde
kunsmatige immuun model op so ’n manier verbeter dat die model die
aantal groepe in ’n data stel dinamies kan bepaal met minimum tot
geen gebruiker invloed. ’n Tegniek om kunsmatige data stelle te
genereer vir data groepering in dinamiese omgewings word dan
voorgestel. Laastens word die oorspronklik voorgestelde model sowel
as die verbeterde model wat…
Advisors/Committee Members: Engelbrecht, Andries P. (advisor).
Subjects/Keywords: Klonale
seleksie; Kunsmatige
immuun netwerke; Immuun netwerk
topologieë; Groepering van
dinamiese data; Affiniteit
volwassewording; Somatiese
hiper mutasie; Kunsmatige
limfosiete; Data
groepering; Affinity
maturation; Clonal
selection; Artificial
lymphocytes; Somatic hyper
mutation; Groepering
prestasie maatreëls; Data
clustering; Dinamiese
groepering;
UCTD
Record Details
Similar Records
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Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Graaff, A. J. (. (2011). A local network
neighbourhood artificial immune system. (Doctoral Dissertation). University of Pretoria. Retrieved from http://hdl.handle.net/2263/28799
Chicago Manual of Style (16th Edition):
Graaff, A J (Alexander. “A local network
neighbourhood artificial immune system.” 2011. Doctoral Dissertation, University of Pretoria. Accessed January 16, 2021.
http://hdl.handle.net/2263/28799.
MLA Handbook (7th Edition):
Graaff, A J (Alexander. “A local network
neighbourhood artificial immune system.” 2011. Web. 16 Jan 2021.
Vancouver:
Graaff AJ(. A local network
neighbourhood artificial immune system. [Internet] [Doctoral dissertation]. University of Pretoria; 2011. [cited 2021 Jan 16].
Available from: http://hdl.handle.net/2263/28799.
Council of Science Editors:
Graaff AJ(. A local network
neighbourhood artificial immune system. [Doctoral Dissertation]. University of Pretoria; 2011. Available from: http://hdl.handle.net/2263/28799
RMIT University
10.
Tomita, T.
Subspecies distribution and virulence factors of Streptococcus uberis.
Degree: 2008, RMIT University
URL: http://researchbank.rmit.edu.au/view/rmit:13878
► Mastitis is the single most important cause of financial loss to the dairy industry worldwide with production losses amounting to more than US 2 billion…
(more)
▼ Mastitis is the single most important cause of financial loss to the dairy industry worldwide with production losses amounting to more than US 2 billion annually. In Australia, losses as a result of mastitis are estimated to be in excess of A 150 million per year, mainly due to decreased milk output and reduced milk quality payments. Although the introduction of mastitis control schemes has been successful in reducing the incidence of contagious mastitis caused by Streptococcus agalactiae and Staphylococcus aureus in dairy herds, these measures have had little impact on environmental pathogens, notably Streptococcus uberis and Escherichia coli . In this study, approximately 300 individual quarter milk samples from cases comprising both clinical and subclinical cases of mastitis and from cows with low somatic cell counts in their milk were screened. In total, 46 isolates were confirmed to be S. uberis and used in all subsequent experiments. Analyses of the Australian isolates by pulsed-field gel electrophoresis (PFGE) demonstrated the occurrence of a genetically diverse population, with the predomination of no particular clone or PFGE type. The possible transmission of specific S. uberis PFGE type[s] between individual cows or within quarters of the same cow was observed in four instances but such events were uncommon. In contrast to the genetically diverse population identified by PFGE analyses, multilocus sequence typing (MLST) analysis of the Australian isolates identified a cluster of MLST types associated with clinical and subclinical mastitis and one associated with cows with low somatic cell counts in their milk. Specifically, genotypes belonging to the global clonal complex (GCC) sequence type 5s (ST5s) and GCC ST143s were highly associated ( P < 0.006) with clinical and subclinical mastitis and may represent a lineage of virulent isolates, whereas isolates belonging to GCC ST86 were associated only with cows with low somatic cell counts in their milk. In this study, the highly characterized and clinically diverse Australian S. uberis isolates facilitated the investigation of S. uberis virulence factors utilizing a subtractive hybridization approach. Subtractive hybridization, using genomic DNA from an isolate from a cow with a low cell count to enrich for sequences from genomic DNA from a S. uberis isolate from a case of clinical mastitis, facilitated the identification and characterization of two putative virulence-associated sequences (T3-06 and T4-19) that were highly associated with clinical / subclinical mastitis and GCC type. The subtractive hybridization clone T4-19 encoded a transposase-like gene sequence highly homologous to a sequence identified adjacent to the C5a peptidase virulence factor gene in S. agalactiae . Whilst this transposase-like gene alone is unlikely to represent a S. uberis virulence factor, the T4-19 transposase-like sequence was nevertheless a useful virulence marker exhibiting a high association with both disease status and GCC type in the Australian…
Subjects/Keywords: Fields of Research; Mastitis; S. uberis; PFGE; MLST; clonal complex; ST5; ST143; ST86; subtractive hybridization; transposase; collagen-like surface protein; virulence factor
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Record Details
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APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Tomita, T. (2008). Subspecies distribution and virulence factors of Streptococcus uberis. (Thesis). RMIT University. Retrieved from http://researchbank.rmit.edu.au/view/rmit:13878
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Tomita, T. “Subspecies distribution and virulence factors of Streptococcus uberis.” 2008. Thesis, RMIT University. Accessed January 16, 2021.
http://researchbank.rmit.edu.au/view/rmit:13878.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Tomita, T. “Subspecies distribution and virulence factors of Streptococcus uberis.” 2008. Web. 16 Jan 2021.
Vancouver:
Tomita T. Subspecies distribution and virulence factors of Streptococcus uberis. [Internet] [Thesis]. RMIT University; 2008. [cited 2021 Jan 16].
Available from: http://researchbank.rmit.edu.au/view/rmit:13878.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Tomita T. Subspecies distribution and virulence factors of Streptococcus uberis. [Thesis]. RMIT University; 2008. Available from: http://researchbank.rmit.edu.au/view/rmit:13878
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
11.
McCoy, Paul.
Hyper Progressive Ambition Theory Through the Lens of Presidents John F. Kennedy and Barack H. Obama: Candidacy, Election, and Transition to the Presidency.
Degree: 2014, Johns Hopkins University
URL: http://jhir.library.jhu.edu/handle/1774.2/37249
► Joseph Schlesinger in his seminal work Ambition and Politics: Political Careers in the United States defined the particular types of ambition that determined which politicians…
(more)
▼ Joseph Schlesinger in his seminal work Ambition and Politics: Political Careers in the United States defined the particular types of ambition that determined which politicians ran for what level of political office. In building out Schlesinger’s typology to include the innovative concept of
hyper progressive ambition, this paper seeks to answer Schlesinger’s unasked question of just how progressively ambitious politicians would achieve their goals once elected to office. The campaigns, presidential transitions and early administrations of presidents John F. Kennedy and Barack H. Obama are examined to identify the characteristics of the
hyper progressive candidate-turned-president and determine what safeguards such candidates should take to best position themselves for a successful administration. The paper will describe the foundations of progressive ambition theory as termed by Arthur Schlesinger in his seminal work "Ambition and Politics: Political Careers in the
United States", then identify the theory's failure to explain 'how' politicians run for higher office. It will explore selected data tests to demonstrate via quantitative data and examples from qualitative research how candidates-turned-leaders Kennedy and Obama actuated their
hyper progressive ambitious abilities and stratagems. Synthesized from this paper’s findings,
hyper progressive politicians will 1. Know generally what they hope to accomplish in office, but 2. Will not have accrued the necessary experience and connections to actuate stated goals. To profit from the lessons of this paper and thus from the past experience of the Kennedy and Obama transitions and early administrations, new
hyper progressive candidates must first maintain existing decision making and risk management structures. Secondly, they must be sure to both 1. Appoint advisers from a variety of different schools of thought e.g., not Clintonian economists only, and 2. They must avoid bringing predominately
inexperienced hands into the advisory ranks (the
hyper progressive president themselves is already lacking in government experience). By adhering to these transition guidelines, the next
hyper progressive candidate-turned-president may hope to have installed satisfactory safeguards against the potential pitfalls of the
hyper progressive candidate. By controlling for their inexperience, the
hyper progressive president may effectively embark on the enterprises they so winningly proposed to the American people.
Advisors/Committee Members: Hill, Kathy W (advisor).
Subjects/Keywords: hyper;
ambition
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APA ·
Chicago ·
MLA ·
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CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
McCoy, P. (2014). Hyper Progressive Ambition Theory Through the Lens of Presidents John F. Kennedy and Barack H. Obama: Candidacy, Election, and Transition to the Presidency. (Thesis). Johns Hopkins University. Retrieved from http://jhir.library.jhu.edu/handle/1774.2/37249
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
McCoy, Paul. “Hyper Progressive Ambition Theory Through the Lens of Presidents John F. Kennedy and Barack H. Obama: Candidacy, Election, and Transition to the Presidency.” 2014. Thesis, Johns Hopkins University. Accessed January 16, 2021.
http://jhir.library.jhu.edu/handle/1774.2/37249.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
McCoy, Paul. “Hyper Progressive Ambition Theory Through the Lens of Presidents John F. Kennedy and Barack H. Obama: Candidacy, Election, and Transition to the Presidency.” 2014. Web. 16 Jan 2021.
Vancouver:
McCoy P. Hyper Progressive Ambition Theory Through the Lens of Presidents John F. Kennedy and Barack H. Obama: Candidacy, Election, and Transition to the Presidency. [Internet] [Thesis]. Johns Hopkins University; 2014. [cited 2021 Jan 16].
Available from: http://jhir.library.jhu.edu/handle/1774.2/37249.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
McCoy P. Hyper Progressive Ambition Theory Through the Lens of Presidents John F. Kennedy and Barack H. Obama: Candidacy, Election, and Transition to the Presidency. [Thesis]. Johns Hopkins University; 2014. Available from: http://jhir.library.jhu.edu/handle/1774.2/37249
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
12.
Benedetti, Vladimiro.
Sous-variétés spéciales des espaces homogènes : Special subvarieties of homogeneous spaces.
Degree: Docteur es, Mathématiques. Géométrie algébrique complexe, 2018, Aix Marseille Université
URL: http://www.theses.fr/2018AIXM0224
► Le but de cette thèse est de construire de nouvelles variétés algébriques complexes de Fano et à canonique triviale dans les espaces homogènes et d'analyser…
(more)
▼ Le but de cette thèse est de construire de nouvelles variétés algébriques complexes de Fano et à canonique triviale dans les espaces homogènes et d'analyser leur géométrie. On commence en construisant les variétés spéciales comme lieux de zéros de fibrés homogènes dans les grassmanniennes généralisées. On donne une complète classification en dimension 4. On prouve que les uniques variétés de dimension 4 hyper-Kahleriennes ainsi construites sont les exemples de Beauville-Donagi et Debarre-Voisin. Le même résultat vaut dans les grassmanniennes ordinaires en toute dimension quand le fibré est irréductible. Ensuite on utilise les lieux de dégénérescence orbitaux (ODL), qui généralisent les lieux de dégénérescence classiques, pour construire d'autres variétés. On rappelle les propriétés basiques des ODL, qu'on définit à partir d'une adhérence d'orbite. On construit trois schémas de Hilbert de deux points sur une K3 comme ODL, et beaucoup d'autres exemples de variétés de Calabi-Yau et de Fano. Puis on étudie les adhérences d'orbites dans les représentations de carquois, et on décrit des effondrements de Kempf pour celles de type A_n et D_4; ceci nous permet de construire davantage de variétés spéciales comme ODL. Pour finir, on analyse les grassmanniennes bisymplectiques, qui sont des Fano particulières. Elles admettent l'action d'un tore avec un nombre fini de points fixes. On étudie leurs petites déformations. Ensuite, on étudie la cohomologie (équivariante) des grassmanniennes symplectiques, qui est utile pour mieux comprendre la cohomologie des grassmanniennes bisymplectiques. On analyse en détail un cas explicite en dimension 6.
The aim of this thesis is to construct new interesting complex algebraic Fano varieties and varieties with trivial canonical bundle and to analyze their geometry. In the first part we construct special varieties as zero loci of homogeneous bundles inside generalized Grassmannians. We give a complete classification for varieties of small dimension when the bundle is completely reducible. Thus, we prove that the only fourfolds with trivial canonical bundle so constructed which are hyper-Kahler are the examples of Beauville-Donagi and Debarre-Voisin. The same holds in ordinary Grassmannians when the bundle is irreducible in any dimension. In the second part we use orbital degeneracy loci (ODL), which are a generalization of classical degeneracy loci, to construct new varieties. ODL are constructed from a model, which is usually an orbit closure inside a representation. We recall the fundamental properties of ODL. As an illustration of the construction, we construct three Hilbert schemes of two points on a K3 surface as ODL, and many examples of Calabi-Yau and Fano threefolds and fourfolds. Then we study orbit closures inside quiver representations, and we provide crepant Kempf collapsings for those of type A_n, D_4; this allows us to construct some special varieties as ODL.Finally we focus on a particular class of Fano varieties, namely bisymplectic Grassmannians. These varieties admit the…
Advisors/Committee Members: Manivel, Laurent (thesis director).
Subjects/Keywords: Géométrie algébrique complexe; Espaces homogènes; Actions de groupes algébriques; Fibrés vectoriels; Variétés de Fano; Variétés de Calabi-Yau; Variétés hyper-Kahlériennes; Représentations de carquois; Complex algebraic geometry; Homogeneous spaces; Algebraic group actions; Vector bundles; Fano varieties; Calabi-Yau varieties; Hyper-Kahler varieties; Quiver representations
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APA (6th Edition):
Benedetti, V. (2018). Sous-variétés spéciales des espaces homogènes : Special subvarieties of homogeneous spaces. (Doctoral Dissertation). Aix Marseille Université. Retrieved from http://www.theses.fr/2018AIXM0224
Chicago Manual of Style (16th Edition):
Benedetti, Vladimiro. “Sous-variétés spéciales des espaces homogènes : Special subvarieties of homogeneous spaces.” 2018. Doctoral Dissertation, Aix Marseille Université. Accessed January 16, 2021.
http://www.theses.fr/2018AIXM0224.
MLA Handbook (7th Edition):
Benedetti, Vladimiro. “Sous-variétés spéciales des espaces homogènes : Special subvarieties of homogeneous spaces.” 2018. Web. 16 Jan 2021.
Vancouver:
Benedetti V. Sous-variétés spéciales des espaces homogènes : Special subvarieties of homogeneous spaces. [Internet] [Doctoral dissertation]. Aix Marseille Université 2018. [cited 2021 Jan 16].
Available from: http://www.theses.fr/2018AIXM0224.
Council of Science Editors:
Benedetti V. Sous-variétés spéciales des espaces homogènes : Special subvarieties of homogeneous spaces. [Doctoral Dissertation]. Aix Marseille Université 2018. Available from: http://www.theses.fr/2018AIXM0224
Indian Institute of Science
13.
Pandey, Ravindra.
Probing The Equilibrium Geometry Of Weakly Interacting Systems In Solution By Hyper-Rayleigh Scattering.
Degree: PhD, Faculty of Science, 2014, Indian Institute of Science
URL: http://etd.iisc.ac.in/handle/2005/2365
► Under the electric dipole approximation, second harmonic of the incident light is scattered by a collection of randomly oriented molecular dipoles in solution due to…
(more)
▼ Under the electric dipole approximation, second harmonic of the incident light is scattered by a collection of randomly oriented molecular dipoles in solution due to instantaneous orientational fluctuation which is directional. If two such dipoles are correlated in space through intermolecular or other interactions, the intensity of the second harmonic scattered light (SHSL) will be related to the extent of such interactions. If two dipoles are arranged in a particular geometry by design, the geometry will determine the intensity of the SHSL. If a molecule has no dipole moment, the intensity of the SHSL will be less and is only allowed by higher order electric multipoles. If two such zero-dipole molecules interact with each other and transfer some amount of electronic charge from one to the other, the induced dipole moment will give rise to an enhanced SHSL. However, along with the direction of the dipole moment from the donor to the acceptor, the actual geometry of such molecular dimer/
complex should also play an important role to determine the nature of the SHSL response. If all the isotropic nonzero components of first hyperpolarizability (β) are taken into account, from the measurement of β and related quantities such as depolarization ratios, in solution it should be possible to derive information about the geometry of the dimer/
complex. This is precisely the motivation behind this thesis.
Chapter 1 gives a brief introduction of 1:1 charge transfer (CT) complexes between a donor and an acceptor and their importance in chemistry. It also contains an introduction to nonlinear optics, various spectroscopic techniques to characterize CT complexes, etc. The motivation of extracting the geometry of such complexes from
hyper-Rayleigh scattering (HRS) measurements in solution is presented in this chapter.
In Chapter 2, all the experimental details of the unpolarized and polarization resolved HRS measurements at various excitation wavelengths have been described. Generation of infrared wavelengths (1543 nm and 1907 nm) using stimulated Raman scattering in gases have also been discussed.
In Chapter 3, the first hyperpolarizability (βHRS) for two series of 1:1 molecular complexes between methyl substituted benzene donors with tetrachloro-p-benzoquinone (CHL) and dicyanodichloro-p-benzoquinone (DDQ) acceptors in solution at 1543 nm have been presented. Enhancement of βHRS due to charge transfer from the donor to the acceptor molecule which was predicted theoretically has been verified. Using linearly (electric field vector along X direction) and circularly polarized incident light, respectively, two macroscopic depolarization ratios D = I2ω,X,X/I2ω,Z,X and D' = I2ω,X,C/I2ω,Z,C in the laboratory fixed XYZ frame by detecting the SHSL in a polarization resolved fashion have been measured. The experimentally obtained first hyperpolarizability (βHRS), D and D' values, are then matched with the theoretically calculated values from single and double configuration interaction calculations using the Zerner’s intermediate neglect…
Advisors/Committee Members: Das, Puspendu K (advisor).
Subjects/Keywords: Rayleigh Scattering; Scattering - Equilibrium - Geometry; Charge Transfer Complexes; Hyperpolarization; Nonlinear Optics; Charge Transfer Complexes - Geometry; Hyper-Rayleigh Scattering; Electron Donor-acceptor Complexes; Pyridine-Chloranil Complex; Optics
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APA (6th Edition):
Pandey, R. (2014). Probing The Equilibrium Geometry Of Weakly Interacting Systems In Solution By Hyper-Rayleigh Scattering. (Doctoral Dissertation). Indian Institute of Science. Retrieved from http://etd.iisc.ac.in/handle/2005/2365
Chicago Manual of Style (16th Edition):
Pandey, Ravindra. “Probing The Equilibrium Geometry Of Weakly Interacting Systems In Solution By Hyper-Rayleigh Scattering.” 2014. Doctoral Dissertation, Indian Institute of Science. Accessed January 16, 2021.
http://etd.iisc.ac.in/handle/2005/2365.
MLA Handbook (7th Edition):
Pandey, Ravindra. “Probing The Equilibrium Geometry Of Weakly Interacting Systems In Solution By Hyper-Rayleigh Scattering.” 2014. Web. 16 Jan 2021.
Vancouver:
Pandey R. Probing The Equilibrium Geometry Of Weakly Interacting Systems In Solution By Hyper-Rayleigh Scattering. [Internet] [Doctoral dissertation]. Indian Institute of Science; 2014. [cited 2021 Jan 16].
Available from: http://etd.iisc.ac.in/handle/2005/2365.
Council of Science Editors:
Pandey R. Probing The Equilibrium Geometry Of Weakly Interacting Systems In Solution By Hyper-Rayleigh Scattering. [Doctoral Dissertation]. Indian Institute of Science; 2014. Available from: http://etd.iisc.ac.in/handle/2005/2365
University of Minnesota
14.
Wen, Hao.
Improving Application Performance in the Emerging Hyper-converged Infrastructure.
Degree: PhD, Computer Science, 2019, University of Minnesota
URL: http://hdl.handle.net/11299/206305
► In today's world, the hyper-converged infrastructure is emerging as a new type of infrastructure. In the hyper-converged infrastructure, service providers deploy compute, network and storage…
(more)
▼ In today's world, the hyper-converged infrastructure is emerging as a new type of infrastructure. In the hyper-converged infrastructure, service providers deploy compute, network and storage services on inexpensive hardware rather than expensive proprietary hardware. It allows the service providers to customize the services they can provide by deploying applications in Virtual Machines (VMs) or containers. They can have controls on all resources including compute, network and storage. In this hyper-converged infrastructure, improving the application performance is an important issue. Throughout my Ph.D. research, I have been studying how to improve the performance of applications in the emerging hyper-converged infrastructure. I have been focusing on improving the performance of applications in VMs and in containers when accessing data, and how to improve the performance of applications in the networked storage environment. In the hyper-converged infrastructure, administrators can provide desktop services by deploying Virtual Desktop Infrastructure application (VDI) based on VMs. We first investigate how to identify storage requirements and determine how to meet such requirements with minimal storage resources for VDI application. We create a model to describe the behavior of VDI, and collect real VDI traces to populate this model. The model allows us to identify the storage requirements of VDI and determine the potential bottlenecks in storage. Based on this information, we can tell what capacity and minimum capability a storage system needs in order to support and satisfy a given VDI configuration. We show that our model can describe more fine-grained storage requirements of VDI compared with the rules of thumb which are currently used in industry. In the hyper-converged infrastructure, more and more applications are running in containers. We design and implement a system, called k8sES (k8s Enhanced Storage), that efficiently supports applications with various storage SLOs (Service Level Objectives) along with all other requirements deployed in the Kubernetes environment which is based on containers. Kubernetes (k8s) is a system for managing containerized applications across multiple hosts. The current storage support for containerized applications in k8s is limited. To satisfy users' SLOs, k8s administrators must manually configure storage in advance, and users must know the configurations and capabilities of different types of the provided storage. In k8sES, storage resources are dynamically allocated based on users' requirements. Given users' SLOs, k8sES will select the correct node and storage that can meet their requirements when scheduling applications. The storage allocation mechanism in k8sES also improves the storage utilization efficiency. In addition, we provide a tool to monitor the I/O activities of both applications and storage devices in Kubernetes. With the capabilities of controlling client, network and storage with hyper-convergence, we study how to coordinate different components along the I/O…
Subjects/Keywords: Hyper-convergence; Storage
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APA (6th Edition):
Wen, H. (2019). Improving Application Performance in the Emerging Hyper-converged Infrastructure. (Doctoral Dissertation). University of Minnesota. Retrieved from http://hdl.handle.net/11299/206305
Chicago Manual of Style (16th Edition):
Wen, Hao. “Improving Application Performance in the Emerging Hyper-converged Infrastructure.” 2019. Doctoral Dissertation, University of Minnesota. Accessed January 16, 2021.
http://hdl.handle.net/11299/206305.
MLA Handbook (7th Edition):
Wen, Hao. “Improving Application Performance in the Emerging Hyper-converged Infrastructure.” 2019. Web. 16 Jan 2021.
Vancouver:
Wen H. Improving Application Performance in the Emerging Hyper-converged Infrastructure. [Internet] [Doctoral dissertation]. University of Minnesota; 2019. [cited 2021 Jan 16].
Available from: http://hdl.handle.net/11299/206305.
Council of Science Editors:
Wen H. Improving Application Performance in the Emerging Hyper-converged Infrastructure. [Doctoral Dissertation]. University of Minnesota; 2019. Available from: http://hdl.handle.net/11299/206305
Mississippi State University
15.
Jubirt, Madison M.
Potential of great egrets to be vectors for the transmission of a virulent strain of <i>Aeromonas hydrophila</i> between channel catfish culture pond.
Degree: MS, Veterinary Medicine, College of, 2012, Mississippi State University
URL: http://sun.library.msstate.edu/ETD-db/theses/available/etd-07052012-145430/
;
► <i>Aeromonas hydrophila</i> is a Gram-negative, rod shaped, facultative anaerobic bacterium that is ubiquitous to freshwater and slightly brackish aquatic environments and can cause infections…
(more)
▼ <i>Aeromonas hydrophila</i> is a Gram-negative, rod shaped, facultative anaerobic bacterium that is ubiquitous to freshwater and slightly brackish aquatic environments and can cause infections in fish, humans, reptiles, and avian species. Recent severe outbreaks of disease in catfish aquaculture have been associated with a highly
virulent <i>Aeromonas hydrophila</i> strain (VAH) that is genetically distinct from less
virulent strains.
Given that <i>A. hydrophila</i> is known to infect birds, we hypothesized that fish eating birds may serve as a reservoir for VAH and spread the pathogen by flying to uninfected ponds. Great Egrets were used in this transmission model because these wading birds frequently predate catfish farms. We found that Great Egrets that were fed VAH infected catfish shed VAH demonstrating their potential to spread VAH. Histologically there were changes found in selected tissue samples.
Advisors/Committee Members: Larry A. Hanson (chair), Frederick L. Cunningham (committee member), Lora Petrie-Hanson (committee member).
Subjects/Keywords: Virulent Aeromonas Hydrophila (VAH); Aeromonas hydrophila; Ictalurus punctatus; aquaculture; Adrea alba
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APA (6th Edition):
Jubirt, M. M. (2012). Potential of great egrets to be vectors for the transmission of a virulent strain of <i>Aeromonas hydrophila</i> between channel catfish culture pond. (Masters Thesis). Mississippi State University. Retrieved from http://sun.library.msstate.edu/ETD-db/theses/available/etd-07052012-145430/ ;
Chicago Manual of Style (16th Edition):
Jubirt, Madison M. “Potential of great egrets to be vectors for the transmission of a virulent strain of <i>Aeromonas hydrophila</i> between channel catfish culture pond.” 2012. Masters Thesis, Mississippi State University. Accessed January 16, 2021.
http://sun.library.msstate.edu/ETD-db/theses/available/etd-07052012-145430/ ;.
MLA Handbook (7th Edition):
Jubirt, Madison M. “Potential of great egrets to be vectors for the transmission of a virulent strain of <i>Aeromonas hydrophila</i> between channel catfish culture pond.” 2012. Web. 16 Jan 2021.
Vancouver:
Jubirt MM. Potential of great egrets to be vectors for the transmission of a virulent strain of <i>Aeromonas hydrophila</i> between channel catfish culture pond. [Internet] [Masters thesis]. Mississippi State University; 2012. [cited 2021 Jan 16].
Available from: http://sun.library.msstate.edu/ETD-db/theses/available/etd-07052012-145430/ ;.
Council of Science Editors:
Jubirt MM. Potential of great egrets to be vectors for the transmission of a virulent strain of <i>Aeromonas hydrophila</i> between channel catfish culture pond. [Masters Thesis]. Mississippi State University; 2012. Available from: http://sun.library.msstate.edu/ETD-db/theses/available/etd-07052012-145430/ ;
University of KwaZulu-Natal
16.
Khumalo, Gcinile Zamantungwa.
Treated wastewater effluent as a potential source of virulent and antibiotic resistant Yersinia species in receiving surface water.
Degree: 2015, University of KwaZulu-Natal
URL: http://hdl.handle.net/10413/15835
► Yersinia enterocolitica is a potentially pathogenic bacterium transmitted through the faecal-oral route. Typical symptoms include those associated with gastrointestinal disease, although infection can also lead…
(more)
▼ Yersinia enterocolitica is a potentially pathogenic bacterium transmitted through the faecal-oral
route. Typical symptoms include those associated with gastrointestinal disease, although
infection can also lead to more serious and invasive illnesses, particularly in sensitive
populations. Previous studies have detected Y. enterocolitica in surface water in various parts of
the world, and studies have reported the intake of untreated water to be one of the potential risk
factors for Y. enterocolitica infection. This study investigated the antibiotic resistant patterns and
the virulence determinants of the previously identified Y. enterocolitica in treated wastewater
effluents and the receiving rivers. In addition, the antibiogram and virulence factors of these
isolates were determined in order to establish the possible effects posed by these isolates to the
users of receiving surface waters. Finally, the genetic relatedness of the isolates was established
by Random Amplified Polymorphic DNA (RAPD-PCR). The antibiotic susceptibility assays
revealed that the isolates were resistant to ampicillin (100%), amoxicillin (98%), cefuroxime
(96%), cefalothin (90%), streptomycin (93%), chloramphenicol (100%), tetracycline (100%) and
trimethoprim (100%). The calculated multiple antibiotic resistance (MAR) indices of the Y.
enterocolitica isolates ranged from 0.5-0.66, suggesting high multi-antibiotic resistance among
the isolates. A high prevalence (59%) of class 2 integrin was found among the isolates, with 26
and 6% of the isolates in possession of class1 and class 3, respectively. The integrase genes
detection showed that the isolates possessed 3 classes of integrons, detected in 59%, 26% and
6% of the isolates, respectively. The virulence determinant assays using crystal violet staining
showed that only 21% (15/70) of the isolates could retain the purple colour suggesting that they
may be the
virulent strain of Y. enterocolitica. The negative MBL activity suggests that the tested
isolates do not demonstrate any hydrolytic activity for the degradation of cephalosporins.
Virulence gene detection via PCR showed that the most abundant gene is the ystA (56%)
followed by ail (34%), both chromosomally located. The plasmid located genes were detected in
3% of the isolates for both Vir/Lcr and yadA. The genotypic characterization of the tested
isolates revealed two main clusters (A and B), with cluster A comprising the majority of the
isolates (68%) and include the Y. enterocolitica positive control, whilst cluster B grouped 31% of
the isolates. had 31% similarity to the control.
Advisors/Committee Members: Pillay, Balakrishna. (advisor), Olaniran, Ademola Olufolahan. (advisor).
Subjects/Keywords: Theses - Microbiology.; Treated wastewater.; Virulent.; Antibiotic.; Yersinia species.
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Manager
APA (6th Edition):
Khumalo, G. Z. (2015). Treated wastewater effluent as a potential source of virulent and antibiotic resistant Yersinia species in receiving surface water. (Thesis). University of KwaZulu-Natal. Retrieved from http://hdl.handle.net/10413/15835
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Khumalo, Gcinile Zamantungwa. “Treated wastewater effluent as a potential source of virulent and antibiotic resistant Yersinia species in receiving surface water.” 2015. Thesis, University of KwaZulu-Natal. Accessed January 16, 2021.
http://hdl.handle.net/10413/15835.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Khumalo, Gcinile Zamantungwa. “Treated wastewater effluent as a potential source of virulent and antibiotic resistant Yersinia species in receiving surface water.” 2015. Web. 16 Jan 2021.
Vancouver:
Khumalo GZ. Treated wastewater effluent as a potential source of virulent and antibiotic resistant Yersinia species in receiving surface water. [Internet] [Thesis]. University of KwaZulu-Natal; 2015. [cited 2021 Jan 16].
Available from: http://hdl.handle.net/10413/15835.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Khumalo GZ. Treated wastewater effluent as a potential source of virulent and antibiotic resistant Yersinia species in receiving surface water. [Thesis]. University of KwaZulu-Natal; 2015. Available from: http://hdl.handle.net/10413/15835
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Wilfrid Laurier University
17.
Mitchell, Scott.
ZOMBIES IN BACTERIAL GENOMES: IDENTIFICATION AND ANALYSIS OF PREVIOUSLY VIRULENT PHAGE.
Degree: 2014, Wilfrid Laurier University
URL: https://scholars.wlu.ca/etd/1687
► Bacteriophage (or ‘phage’) are viruses that infect and reproduce within their bacterial hosts. They have a major global impact on bacterial evolution and ecology, and…
(more)
▼ Bacteriophage (or ‘phage’) are viruses that infect and reproduce within their bacterial hosts. They have a major global impact on bacterial evolution and ecology, and might influence the pathogenicity of their host bacterium by providing virulence factors. Phage can either be described as “virulent” or “temperate”; the distinguishing feature between the two is their method of replication.
This study sought to identify phage sequences within bacterial host genomes and determine the life cycle of the phage, exploring whether there is a connection between defective phage and previously virulent phage. It would normally be expected that any phage sequences identified within a bacterial host would have a temperate life cycle, since only temperate phage enter the lysogenic cycle and insert their DNA into the host as a ‘prophage,’ while virulent phage replicate via the lytic cycle, in which phage DNA replicates separately from that of the host’s and infected cells are lysed.
Defective phage–‘zombies’ in bacterial genomes–are dormant phage that have become inactive through mutational decay or some other process. It is possible that some of these defective phage are in fact previously virulent phage that have become accidentally inserted within the host genome.
This study detected phage within bacterial genomes using the prophage identification tools PHAge Search Tool (PHAST) and Prophage Finder. Identified sequences were categorized as ‘intact,’ ‘questionable,’ or ‘incomplete’; questionable and incomplete phage were classified as defective. The lifestyles of the uncovered phage sequences were then determined using PHACTS; six phage were identified as possibly virulent. The life cycles of the phage were further analyzed by assessing the genomic signature distances (GSD) and codon adaptation indexes (CAI) for each phage. Three phage were shown to have a GSD consistent with a virulent life cycle, and the CAI values of four phage corresponded with that of virulent phage. Although previous studies have indicated that some virulent phage may have a temperate lineage, identifying prophage as previously virulent is a novel finding. This has implications for our understanding of phage life cycles and the infection process, as it challenges the idea that only temperate phage insert their DNA into the host genome.
Subjects/Keywords: Bioinformatics; bacteriophage; zombie; virulent; temperate; life cycle; Bioinformatics
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APA (6th Edition):
Mitchell, S. (2014). ZOMBIES IN BACTERIAL GENOMES: IDENTIFICATION AND ANALYSIS OF PREVIOUSLY VIRULENT PHAGE. (Thesis). Wilfrid Laurier University. Retrieved from https://scholars.wlu.ca/etd/1687
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Mitchell, Scott. “ZOMBIES IN BACTERIAL GENOMES: IDENTIFICATION AND ANALYSIS OF PREVIOUSLY VIRULENT PHAGE.” 2014. Thesis, Wilfrid Laurier University. Accessed January 16, 2021.
https://scholars.wlu.ca/etd/1687.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Mitchell, Scott. “ZOMBIES IN BACTERIAL GENOMES: IDENTIFICATION AND ANALYSIS OF PREVIOUSLY VIRULENT PHAGE.” 2014. Web. 16 Jan 2021.
Vancouver:
Mitchell S. ZOMBIES IN BACTERIAL GENOMES: IDENTIFICATION AND ANALYSIS OF PREVIOUSLY VIRULENT PHAGE. [Internet] [Thesis]. Wilfrid Laurier University; 2014. [cited 2021 Jan 16].
Available from: https://scholars.wlu.ca/etd/1687.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Mitchell S. ZOMBIES IN BACTERIAL GENOMES: IDENTIFICATION AND ANALYSIS OF PREVIOUSLY VIRULENT PHAGE. [Thesis]. Wilfrid Laurier University; 2014. Available from: https://scholars.wlu.ca/etd/1687
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Mississippi State University
18.
Arroyo-Llantin, Norman Noriel.
Isolation, antibiotic resistance and clonal similarities of Salmonella spp. in catfish and processing facilities.
Degree: PhD, Food Science, Nutrition, and Health Promotion, 2013, Mississippi State University
URL: http://sun.library.msstate.edu/ETD-db/theses/available/etd-02092013-101239/
;
► <i>Salmonella</i> spp. is a human pathogen that has been reported in catfish, but with conflicting results. <i>Salmonella</i> spp. was isolated from live catfish, catfish…
(more)
▼ <i>Salmonella</i> spp. is a human pathogen that has been reported in catfish, but with
conflicting results. <i>Salmonella</i> spp. was isolated from live catfish, catfish products and
the processing environment during catfish production, followed by evaluation of their
antibiotic resistance and
clonal similarities. Distinction of <i>Salmonella</i> spp. was increased by lowering background microflora with the addition of the antimicrobial novobiocin to the agar media. More than ten <i>Salmonella</i> serotypes were isolated from catfish and
catfish products, such as live, chilled fillets, frozen fillets, and conveyor belts in catfish
processing facilities. The isolates that were recovered include <i>Salmonella</i> ser.
Typhimurium, Barranquilla, Mbadaka, Putten, Infantis and Thompson among others. The
number of isolated <i>Salmonella</i> spp. and serotypes varied between sampling in catfish
facilities.
Clonal similarities of <i>Salmonella</i> spp. were found within sampling but did not
show persistency among sampling periods, suggesting the opportunistic nature of the
pathogen. <i>Salmonella</i> ser. Typhimurium was the most predominant isolate in live catfish and similarities were found within sampling but were not persistent among sampling
periods. Antimicrobial resistant <i>Salmonella</i> was identified from the recuperated isolates. All <i>Salmonella</i> spp. isolates, showed resistance to erythromycin, vancomycin and rifampin regardless of the serotype, but resistant genes were absent suggesting that
resistance was due to the pathogens biological nature. These results suggest that it is
possible to recover <i>Salmonella</i> spp. in catfish products, but its opportunistic nature makes it difficult to predict the source or incidence of this pathogen.
Advisors/Committee Members: Juan L. Silva (chair), Taejo Kim (committee member), Diane K. Tidwell (committee member), M. Wes Schilling (committee member), Lewis R. Brown (committee member).
Subjects/Keywords: antibiotic resisatnce; clonal similarities; Salmonella
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Chicago ·
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APA (6th Edition):
Arroyo-Llantin, N. N. (2013). Isolation, antibiotic resistance and clonal similarities of Salmonella spp. in catfish and processing facilities. (Doctoral Dissertation). Mississippi State University. Retrieved from http://sun.library.msstate.edu/ETD-db/theses/available/etd-02092013-101239/ ;
Chicago Manual of Style (16th Edition):
Arroyo-Llantin, Norman Noriel. “Isolation, antibiotic resistance and clonal similarities of Salmonella spp. in catfish and processing facilities.” 2013. Doctoral Dissertation, Mississippi State University. Accessed January 16, 2021.
http://sun.library.msstate.edu/ETD-db/theses/available/etd-02092013-101239/ ;.
MLA Handbook (7th Edition):
Arroyo-Llantin, Norman Noriel. “Isolation, antibiotic resistance and clonal similarities of Salmonella spp. in catfish and processing facilities.” 2013. Web. 16 Jan 2021.
Vancouver:
Arroyo-Llantin NN. Isolation, antibiotic resistance and clonal similarities of Salmonella spp. in catfish and processing facilities. [Internet] [Doctoral dissertation]. Mississippi State University; 2013. [cited 2021 Jan 16].
Available from: http://sun.library.msstate.edu/ETD-db/theses/available/etd-02092013-101239/ ;.
Council of Science Editors:
Arroyo-Llantin NN. Isolation, antibiotic resistance and clonal similarities of Salmonella spp. in catfish and processing facilities. [Doctoral Dissertation]. Mississippi State University; 2013. Available from: http://sun.library.msstate.edu/ETD-db/theses/available/etd-02092013-101239/ ;
University of Cambridge
19.
Cassidy, John.
Studying the Clonal Origins of Drug Resistance in Human Breast Cancers.
Degree: PhD, 2019, University of Cambridge
URL: https://www.repository.cam.ac.uk/handle/1810/290759
► Despite remarkable advances in our understanding of the drivers of human malignancies, new targeted therapies often fail to show sufficient efficacy in clinical trials. Indeed,…
(more)
▼ Despite remarkable advances in our understanding of the drivers of human malignancies, new targeted therapies often fail to show sufficient efficacy in clinical trials. Indeed, the cost of bringing a new agent to market has risen substantially in the last several decades, fuelled partly by lack of efficacy in late phase clinical trials. Even in cases where a new agent is deemed 'successful', the development of resistance is often seen as inevitable and clinical responses can be fleeting. Typically, resistance to targeted therapies is thought to arise from pre-existing populations within the tumour, rather than from de novo evolution, yet few studies have experimentally tested this understanding. Indeed, recent reports in the literature have described epigenetically regulated drug tolerant populations within cancers, defined by cell-cycle regulation and/or quiescent repopulation dynamics, drug induced chromatin remodelling or differential transcription factor binding, that can be transient or permanent in nature. This thesis will outline experiments using high complexity molecular barcodes to trace the fate of individual cellular clones in the development of drug resistance. With this technique, cellular clones can be uncoupled from their genomic backgrounds, giving a new depth to our understanding of clonal selection in cancer. In particular, high complexity barcodes are used to identify a pre-existing tamoxifen resistant population in the MCF7 cell line. This resistance phenotype is then linked to the induction of embryonic transcription factor OCT4. Finally, we use our molecular barcoding technique to interrogate the repopulation dynamics of a breast cancer PDX model, supporting their use as complex model systems suitable for studying the origins and consequences of tumour heterogeneity.
Subjects/Keywords: Cancer; drug resistance; clonal tracing
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Cassidy, J. (2019). Studying the Clonal Origins of Drug Resistance in Human Breast Cancers. (Doctoral Dissertation). University of Cambridge. Retrieved from https://www.repository.cam.ac.uk/handle/1810/290759
Chicago Manual of Style (16th Edition):
Cassidy, John. “Studying the Clonal Origins of Drug Resistance in Human Breast Cancers.” 2019. Doctoral Dissertation, University of Cambridge. Accessed January 16, 2021.
https://www.repository.cam.ac.uk/handle/1810/290759.
MLA Handbook (7th Edition):
Cassidy, John. “Studying the Clonal Origins of Drug Resistance in Human Breast Cancers.” 2019. Web. 16 Jan 2021.
Vancouver:
Cassidy J. Studying the Clonal Origins of Drug Resistance in Human Breast Cancers. [Internet] [Doctoral dissertation]. University of Cambridge; 2019. [cited 2021 Jan 16].
Available from: https://www.repository.cam.ac.uk/handle/1810/290759.
Council of Science Editors:
Cassidy J. Studying the Clonal Origins of Drug Resistance in Human Breast Cancers. [Doctoral Dissertation]. University of Cambridge; 2019. Available from: https://www.repository.cam.ac.uk/handle/1810/290759
20.
Prevedello, Giulio.
A mathematical framework for clonal
data analysis.
Degree: 2018, RIAN
URL: http://mural.maynoothuniversity.ie/10652/
► This dissertation reports on the development of the mathematical and statistical framework that was necessary for the analysis of data from a novel single-cell assay…
(more)
▼ This dissertation reports on the development of the mathematical and statistical framework
that was necessary for the analysis of data from a novel single-cell assay designed
to address questions in fundamental biology. Many biological systems function by generating
new cells from activated ancestors through cellular division. To investigate such
systems, a high throughput experimental protocol was recently developed that marks
initial cells so that their cellular offspring, the number of rounds of division from their
ancestor, and their phenotype can be determined. The clonal data that result from this
technique, however, are characterised by familial associations that impede their analysis
using classical quantitative tools, necessitating the development of a new mathematical
framework where suitable statistics are formulated that take these complex dependencies
into account. The design, development and implementation of that framework, as
well as inferences made from its use, are the subject of the present thesis.
Subjects/Keywords: mathematical framework; clonal data; analysis
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Prevedello, G. (2018). A mathematical framework for clonal
data analysis. (Thesis). RIAN. Retrieved from http://mural.maynoothuniversity.ie/10652/
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Prevedello, Giulio. “A mathematical framework for clonal
data analysis.” 2018. Thesis, RIAN. Accessed January 16, 2021.
http://mural.maynoothuniversity.ie/10652/.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Prevedello, Giulio. “A mathematical framework for clonal
data analysis.” 2018. Web. 16 Jan 2021.
Vancouver:
Prevedello G. A mathematical framework for clonal
data analysis. [Internet] [Thesis]. RIAN; 2018. [cited 2021 Jan 16].
Available from: http://mural.maynoothuniversity.ie/10652/.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Prevedello G. A mathematical framework for clonal
data analysis. [Thesis]. RIAN; 2018. Available from: http://mural.maynoothuniversity.ie/10652/
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Cambridge
21.
Cassidy, John.
Studying the clonal origins of drug resistance in human breast cancers.
Degree: PhD, 2019, University of Cambridge
URL: https://doi.org/10.17863/CAM.37959
;
https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.774632
► Despite remarkable advances in our understanding of the drivers of human malignancies, new targeted therapies often fail to show sufficient efficacy in clinical trials. Indeed,…
(more)
▼ Despite remarkable advances in our understanding of the drivers of human malignancies, new targeted therapies often fail to show sufficient efficacy in clinical trials. Indeed, the cost of bringing a new agent to market has risen substantially in the last several decades, fuelled partly by lack of efficacy in late phase clinical trials. Even in cases where a new agent is deemed 'successful', the development of resistance is often seen as inevitable and clinical responses can be fleeting. Typically, resistance to targeted therapies is thought to arise from pre-existing populations within the tumour, rather than from de novo evolution, yet few studies have experimentally tested this understanding. Indeed, recent reports in the literature have described epigenetically regulated drug tolerant populations within cancers, defined by cell-cycle regulation and/or quiescent repopulation dynamics, drug induced chromatin remodelling or differential transcription factor binding, that can be transient or permanent in nature. This thesis will outline experiments using high complexity molecular barcodes to trace the fate of individual cellular clones in the development of drug resistance. With this technique, cellular clones can be uncoupled from their genomic backgrounds, giving a new depth to our understanding of clonal selection in cancer. In particular, high complexity barcodes are used to identify a pre-existing tamoxifen resistant population in the MCF7 cell line. This resistance phenotype is then linked to the induction of embryonic transcription factor OCT4. Finally, we use our molecular barcoding technique to interrogate the repopulation dynamics of a breast cancer PDX model, supporting their use as complex model systems suitable for studying the origins and consequences of tumour heterogeneity.
Subjects/Keywords: Cancer; drug resistance; clonal tracing
Record Details
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Share »
Record Details
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« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Cassidy, J. (2019). Studying the clonal origins of drug resistance in human breast cancers. (Doctoral Dissertation). University of Cambridge. Retrieved from https://doi.org/10.17863/CAM.37959 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.774632
Chicago Manual of Style (16th Edition):
Cassidy, John. “Studying the clonal origins of drug resistance in human breast cancers.” 2019. Doctoral Dissertation, University of Cambridge. Accessed January 16, 2021.
https://doi.org/10.17863/CAM.37959 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.774632.
MLA Handbook (7th Edition):
Cassidy, John. “Studying the clonal origins of drug resistance in human breast cancers.” 2019. Web. 16 Jan 2021.
Vancouver:
Cassidy J. Studying the clonal origins of drug resistance in human breast cancers. [Internet] [Doctoral dissertation]. University of Cambridge; 2019. [cited 2021 Jan 16].
Available from: https://doi.org/10.17863/CAM.37959 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.774632.
Council of Science Editors:
Cassidy J. Studying the clonal origins of drug resistance in human breast cancers. [Doctoral Dissertation]. University of Cambridge; 2019. Available from: https://doi.org/10.17863/CAM.37959 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.774632
22.
Top, J.
Molecular epidemiology of Enterococcus faecium: from commensal to hospital adapted pathogen.
Degree: 2007, University Utrecht
URL: https://dspace.library.uu.nl/handle/1874/21193
;
URN:NBN:NL:UI:10-1874-21193
;
urn:isbn:978-90-3934503-0
;
URN:NBN:NL:UI:10-1874-21193
;
https://dspace.library.uu.nl/handle/1874/21193
► For many years Enterococcus faecium was considered a commensal of the digestive tract, which only sporadically caused opportunistic infections in severely ill patients. Over the…
(more)
▼ For many years Enterococcus faecium was considered a commensal of the digestive tract, which only sporadically caused opportunistic infections in severely ill patients. Over the last two decades, vancomycin resistant E. faecium (VREF) has emerged worldwide as an important cause of nosocomial infections, especially in immunocompromised patients. The global VRE epidemic was preceded by the emergence of ampicillin resistant E. faecium (AREfm) in the United States in the early 1980s. Molecular epidemiological studies of both human- and animal-derived E. faecium isolates using multilocus sequence typing (MLST) revealed the existence of host specific genogroups, including a specific genetic lineage associated with hospital related isolates. These strains were characterized by ampicillin and quinolone resistance. In addition, the presence of the variant esp gene was strongly associated with these outbreak strains. In E. faecalis, esp is contained on a so-called pathogenicity island (PAI) and is considered a putative virulence factor. This thesis describes the development of a rapid and cheap identification scheme for enterococci, which is a prerequisite to take appropriate infection control measures. Furthermore, a rapid molecular typing scheme designated multiple locus variable number tandem repeat analysis (MLVA) has been developed to determine genetic relatedness of E. faecium isolates. Clustering of MLVA profiles confirmed the host-specific genogroups found by MLST, including the hospital specific genetic lineage. Comparison of MLVA with Pulsed Field Gel Electrophoresis (PFGE), considered the “gold standard” typing method for infection control programs in hospitals, revealed that both methods were highly concordant in assigning genotypes and comparable in costs. PFGE revealed a higher discriminatory power, but MLVA was faster. Analysis of the up- and downstream regions of the esp gene among several isolates demonstrated that, like in E. faecalis, esp of E. faecium is contained on a putative pathogenicity island (PAI) with remarkable sequence heterogeneity including insertions, deletions and mutations. The E. faecium PAI has, so far, only been detected in outbreak related and clinical isolates, suggesting a role in nosocomial epidemicity. The population structure of E. faecium was elucidated with MLST and the existence of a distinct clonal complex, designated clonal complex-17 (CC17), associated with the majority of hospital outbreaks and clinical infections in five continents, was documented. This complex is correlated with ampicillin and quinolone resistance and the presence of the PAI. A retrospective study in the UMCU revealed ecological replacement of E. faecalis by CC17 E. faecium, illustrated by a decrease in total numbers of invasive enterococcal infections but an increase in proportions of invasive AREfm. Furthermore, the ratio E. faecium/E. faecalis among bloodstream isolates changed in favor of E. faecium. A similar increase of invasive AREfm was observed in hospitals dispersed over the Netherlands, although…
Subjects/Keywords: Enterococcus faecium; Multiresistant; Ampicillin resistance; Epidemiology; Molecular typing; MLST; Clonal complex-17; MLVA; Pathogenicity island; Enterococcal surface protein (Esp)
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« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Top, J. (2007). Molecular epidemiology of Enterococcus faecium: from commensal to hospital adapted pathogen. (Doctoral Dissertation). University Utrecht. Retrieved from https://dspace.library.uu.nl/handle/1874/21193 ; URN:NBN:NL:UI:10-1874-21193 ; urn:isbn:978-90-3934503-0 ; URN:NBN:NL:UI:10-1874-21193 ; https://dspace.library.uu.nl/handle/1874/21193
Chicago Manual of Style (16th Edition):
Top, J. “Molecular epidemiology of Enterococcus faecium: from commensal to hospital adapted pathogen.” 2007. Doctoral Dissertation, University Utrecht. Accessed January 16, 2021.
https://dspace.library.uu.nl/handle/1874/21193 ; URN:NBN:NL:UI:10-1874-21193 ; urn:isbn:978-90-3934503-0 ; URN:NBN:NL:UI:10-1874-21193 ; https://dspace.library.uu.nl/handle/1874/21193.
MLA Handbook (7th Edition):
Top, J. “Molecular epidemiology of Enterococcus faecium: from commensal to hospital adapted pathogen.” 2007. Web. 16 Jan 2021.
Vancouver:
Top J. Molecular epidemiology of Enterococcus faecium: from commensal to hospital adapted pathogen. [Internet] [Doctoral dissertation]. University Utrecht; 2007. [cited 2021 Jan 16].
Available from: https://dspace.library.uu.nl/handle/1874/21193 ; URN:NBN:NL:UI:10-1874-21193 ; urn:isbn:978-90-3934503-0 ; URN:NBN:NL:UI:10-1874-21193 ; https://dspace.library.uu.nl/handle/1874/21193.
Council of Science Editors:
Top J. Molecular epidemiology of Enterococcus faecium: from commensal to hospital adapted pathogen. [Doctoral Dissertation]. University Utrecht; 2007. Available from: https://dspace.library.uu.nl/handle/1874/21193 ; URN:NBN:NL:UI:10-1874-21193 ; urn:isbn:978-90-3934503-0 ; URN:NBN:NL:UI:10-1874-21193 ; https://dspace.library.uu.nl/handle/1874/21193
23.
Top, J.
Molecular epidemiology of Enterococcus faecium: from commensal to hospital adapted pathogen.
Degree: 2007, University Utrecht
URL: https://dspace.library.uu.nl/handle/1874/21193
;
URN:NBN:NL:UI:10-1874-21193
;
1874/21193
;
urn:isbn:9789039345030
;
URN:NBN:NL:UI:10-1874-21193
;
https://dspace.library.uu.nl/handle/1874/21193
► For many years Enterococcus faecium was considered a commensal of the digestive tract, which only sporadically caused opportunistic infections in severely ill patients. Over the…
(more)
▼ For many years Enterococcus faecium was considered a commensal of the digestive tract, which only sporadically caused opportunistic infections in severely ill patients. Over the last two decades, vancomycin resistant E. faecium (VREF) has emerged worldwide as an important cause of nosocomial infections, especially in immunocompromised patients. The global VRE epidemic was preceded by the emergence of ampicillin resistant E. faecium (AREfm) in the United States in the early 1980s. Molecular epidemiological studies of both human- and animal-derived E. faecium isolates using multilocus sequence typing (MLST) revealed the existence of host specific genogroups, including a specific genetic lineage associated with hospital related isolates. These strains were characterized by ampicillin and quinolone resistance. In addition, the presence of the variant esp gene was strongly associated with these outbreak strains. In E. faecalis, esp is contained on a so-called pathogenicity island (PAI) and is considered a putative virulence factor. This thesis describes the development of a rapid and cheap identification scheme for enterococci, which is a prerequisite to take appropriate infection control measures. Furthermore, a rapid molecular typing scheme designated multiple locus variable number tandem repeat analysis (MLVA) has been developed to determine genetic relatedness of E. faecium isolates. Clustering of MLVA profiles confirmed the host-specific genogroups found by MLST, including the hospital specific genetic lineage. Comparison of MLVA with Pulsed Field Gel Electrophoresis (PFGE), considered the “gold standard” typing method for infection control programs in hospitals, revealed that both methods were highly concordant in assigning genotypes and comparable in costs. PFGE revealed a higher discriminatory power, but MLVA was faster. Analysis of the up- and downstream regions of the esp gene among several isolates demonstrated that, like in E. faecalis, esp of E. faecium is contained on a putative pathogenicity island (PAI) with remarkable sequence heterogeneity including insertions, deletions and mutations. The E. faecium PAI has, so far, only been detected in outbreak related and clinical isolates, suggesting a role in nosocomial epidemicity. The population structure of E. faecium was elucidated with MLST and the existence of a distinct clonal complex, designated clonal complex-17 (CC17), associated with the majority of hospital outbreaks and clinical infections in five continents, was documented. This complex is correlated with ampicillin and quinolone resistance and the presence of the PAI. A retrospective study in the UMCU revealed ecological replacement of E. faecalis by CC17 E. faecium, illustrated by a decrease in total numbers of invasive enterococcal infections but an increase in proportions of invasive AREfm. Furthermore, the ratio E. faecium/E. faecalis among bloodstream isolates changed in favor of E. faecium. A similar increase of invasive AREfm was observed in hospitals dispersed over the Netherlands, although…
Subjects/Keywords: Enterococcus faecium; Multiresistant; Ampicillin resistance; Epidemiology; Molecular typing; MLST; Clonal complex-17; MLVA; Pathogenicity island; Enterococcal surface protein (Esp)
Record Details
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Share »
Record Details
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« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Top, J. (2007). Molecular epidemiology of Enterococcus faecium: from commensal to hospital adapted pathogen. (Doctoral Dissertation). University Utrecht. Retrieved from https://dspace.library.uu.nl/handle/1874/21193 ; URN:NBN:NL:UI:10-1874-21193 ; 1874/21193 ; urn:isbn:9789039345030 ; URN:NBN:NL:UI:10-1874-21193 ; https://dspace.library.uu.nl/handle/1874/21193
Chicago Manual of Style (16th Edition):
Top, J. “Molecular epidemiology of Enterococcus faecium: from commensal to hospital adapted pathogen.” 2007. Doctoral Dissertation, University Utrecht. Accessed January 16, 2021.
https://dspace.library.uu.nl/handle/1874/21193 ; URN:NBN:NL:UI:10-1874-21193 ; 1874/21193 ; urn:isbn:9789039345030 ; URN:NBN:NL:UI:10-1874-21193 ; https://dspace.library.uu.nl/handle/1874/21193.
MLA Handbook (7th Edition):
Top, J. “Molecular epidemiology of Enterococcus faecium: from commensal to hospital adapted pathogen.” 2007. Web. 16 Jan 2021.
Vancouver:
Top J. Molecular epidemiology of Enterococcus faecium: from commensal to hospital adapted pathogen. [Internet] [Doctoral dissertation]. University Utrecht; 2007. [cited 2021 Jan 16].
Available from: https://dspace.library.uu.nl/handle/1874/21193 ; URN:NBN:NL:UI:10-1874-21193 ; 1874/21193 ; urn:isbn:9789039345030 ; URN:NBN:NL:UI:10-1874-21193 ; https://dspace.library.uu.nl/handle/1874/21193.
Council of Science Editors:
Top J. Molecular epidemiology of Enterococcus faecium: from commensal to hospital adapted pathogen. [Doctoral Dissertation]. University Utrecht; 2007. Available from: https://dspace.library.uu.nl/handle/1874/21193 ; URN:NBN:NL:UI:10-1874-21193 ; 1874/21193 ; urn:isbn:9789039345030 ; URN:NBN:NL:UI:10-1874-21193 ; https://dspace.library.uu.nl/handle/1874/21193
24.
Amaral, Rafaela Goularte [UNESP].
Competição intergenotípica em clones comerciais de Eucalyptus spp. e seleção para plantios multiclonais.
Degree: 2016, Universidade Estadual Paulista
URL: http://hdl.handle.net/11449/144966
► Os plantios clonais são comumente utilizados para obter ganhos na produtividade. No entanto, a uniformidade genética, quando em extensas áreas, pode comprometer o desempenho silvicultural…
(more)
▼ Os plantios clonais são comumente utilizados para obter ganhos na produtividade. No entanto, a uniformidade genética, quando em extensas áreas, pode comprometer o desempenho silvicultural do eucalipto. Uma alternativa seria o emprego da mistura de clones em áreas comerciais. Este trabalho foi realizado com o objetivo de comparar a auto e alocompetição entre clones comerciais de Eucalyptus spp., e estimar as capacidades de exercer ou sofrer competição. O experimento foi implantado em delineamento de blocos casualizados, com 12 clones comerciais no espaçamento de 3,6 m x 2,5 m, com 5 plantas por parcela e 3 repetições. Foram avaliados aos 3 e 5 anos os caracteres altura de planta, diâmetro à altura do peito, volume e incremento médio anual. Com os dados médios da parcela foram efetuadas as análises estatísticas e estimados os parâmetros de competição. Houve diferenças entre a auto e a alocompetição para incremento médio anual e volume em ambas as idades avaliadas. O desempenho médio dos clones em auto e alocompetição foram semelhantes, não ocasionando prejuízos para a produção de madeira. A mistura clonal pode ser empregada sempre que for vantajosa do ponto de vista de manejo ou industrial. Os clones diferiram quanto à sua capacidade de exercer ou sofrer competição.
Clonal plantations are commonly used for gains in productivity. However, the genetic uniformity when in extensive areas, can compromise the silvicultural performance of Eucalyptus. An alternative would be the use a mixture of clones in commercial areas. This study was conducted in order to compare auto and allocompetition between commercial clones of Eucalyptus spp., and estimate the capacity to exercise or tolerate competition. The experiment was established in a randomized block design, with 12 commercial clones in the spacing of 3.6 m x 2.5 m, and consists of 5 plants per experimental plot in 3 repetitions. Each clone was evaluated exercising and tolerating competition in all the others, at 3 and 5 years. With the average data were performed statistical analysis and estimated parameters of competition. There were differences between auto and allocompetition the two ages evaluated for annual volume and average increment. The average performance of clones auto and allocompetition were similar, not causing damage to the production of the timber could be used to mix clonal whenever advantageous from the standpoint of handling or manufacturing. Clones differed in their ability to tolerate or exercise competition.
Advisors/Committee Members: Pavan, Bruno Ettore [UNESP], Paula, Rinaldo Cesar de [UNESP], Universidade Estadual Paulista (UNESP).
Subjects/Keywords: Autocompetição; Eucalyptus; Mistura clonal; Competition; Eucalyptus; Mixture clonal
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APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Amaral, R. G. [. (2016). Competição intergenotípica em clones comerciais de Eucalyptus spp. e seleção para plantios multiclonais. (Thesis). Universidade Estadual Paulista. Retrieved from http://hdl.handle.net/11449/144966
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Amaral, Rafaela Goularte [UNESP]. “Competição intergenotípica em clones comerciais de Eucalyptus spp. e seleção para plantios multiclonais.” 2016. Thesis, Universidade Estadual Paulista. Accessed January 16, 2021.
http://hdl.handle.net/11449/144966.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Amaral, Rafaela Goularte [UNESP]. “Competição intergenotípica em clones comerciais de Eucalyptus spp. e seleção para plantios multiclonais.” 2016. Web. 16 Jan 2021.
Vancouver:
Amaral RG[. Competição intergenotípica em clones comerciais de Eucalyptus spp. e seleção para plantios multiclonais. [Internet] [Thesis]. Universidade Estadual Paulista; 2016. [cited 2021 Jan 16].
Available from: http://hdl.handle.net/11449/144966.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Amaral RG[. Competição intergenotípica em clones comerciais de Eucalyptus spp. e seleção para plantios multiclonais. [Thesis]. Universidade Estadual Paulista; 2016. Available from: http://hdl.handle.net/11449/144966
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Euskal Herriko Unibertsitatea / Universidad del País Vasco
25.
Guridi Cortaberria, Andrea.
Genomotipificación de Camylobacter jejuni mediante microarrays de ADN
.
Degree: 2013, Euskal Herriko Unibertsitatea / Universidad del País Vasco
URL: http://hdl.handle.net/10810/10815
► [ES] Campylobacter jejuni es una de las principales causas de diarrea bacteriana a nivel mundial y el antecedente más común en neuropatías periféricas como el…
(more)
▼ [ES] Campylobacter jejuni es una de las principales causas de diarrea bacteriana a nivel mundial y el antecedente más común en neuropatías periféricas como el síndrome Guillain Barré y Miller Fisher. Determinar las diferentes fuentes de infección de Campylobacter ha sido un objetivo largamente perseguido por Gobiernos, Instituciones y científicos en los últimos años. A pesar de todos los esfuerzos, las contribuciones realizadas no permiten determinar con exactitud las diferentes fuentes de infección, lo cual ha dificultado el establecimiento de estrategias eficaces de control para reducir la presencia de C. jejuni en la cadena alimentaria. Más recientemente, el interés se ha volcado en la utilización del genoma completo ya que la secuenciación del mismo ha permitido el desarrollo de microarrays que permiten estudiar multitud de genes, simultáneamente. Debido a todo esto, la finalidad del trabajo fue determinar el grado de variabilidad (diversidad y/o posible plasticidad) genómica entre cepas de Campylobacter jejuni procedentes de diversas áreas geográficas y diferentes fuentes de aislamiento, al objeto de detectar posibles genes que pueda emplearse como marcadores genéticos. Para ello, nuestros objetivos específicos fueron los siguientes: 1. Determinar las condiciones experimentales más adecuadas para la hibridación en el microarray de ADN, asegurando la reproducibilidad entre ensayos, minimizando la presencia de hibridaciones cruzadas y asegurando la discriminación entre las señales de fluorescencia para los genes presentes y los ausentes o divergentes. 2. Confeccionar una colección multigeográfica de cepas de C. jejuni que incluya aislamientos no clonales, según alelos de la región SVR (Short Variable Region) del gen flaA, aislados en muestras humanas y de pollo. 3. Analizar la colección de cepas seleccionadas mediante CGH (Comparative Genomic Hybridization) utilizando microarrays de ADN (genoma universal), con el fin de encontrar posibles marcadores predictivos.4. Determinar el grado de variabilidad y estructura genética que presentan las cepas seleccionadas mediante métodos bayesianos de inferencia filogenética.
Advisors/Committee Members: Fernández Astorga, Aurora (advisor), Rodrigo Nionsalve, Rodrigo (advisor).
Subjects/Keywords: ADN;
DNA;
microarray;
Campylobacter;
Campylobacter jejuni;
array;
microchip;
genética;
genetika;
Guillain-Barré;
genomotipificación;
genomotipifikazioa;
genomotyping;
marcador genético;
markatzaile genetikoa;
genetic marker;
biología molecular;
molecular biology;
biologia molekularra;
Miller Fisher;
fuente de infección;
variabilidad genómica;
CGH;
genetic variability;
comparative genomic;
hybridization;
short variable region flaa;
CJIE;
complejo clonal;
clonal complex;
islas genómicas;
genomic islands;
irla genomikoak;
regiones de plasticidad hipervariables;
PR;
plasticity regions;
ptet y pvir;
plasmids;
plásmidos;
plasmidoak
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APA (6th Edition):
Guridi Cortaberria, A. (2013). Genomotipificación de Camylobacter jejuni mediante microarrays de ADN
. (Doctoral Dissertation). Euskal Herriko Unibertsitatea / Universidad del País Vasco. Retrieved from http://hdl.handle.net/10810/10815
Chicago Manual of Style (16th Edition):
Guridi Cortaberria, Andrea. “Genomotipificación de Camylobacter jejuni mediante microarrays de ADN
.” 2013. Doctoral Dissertation, Euskal Herriko Unibertsitatea / Universidad del País Vasco. Accessed January 16, 2021.
http://hdl.handle.net/10810/10815.
MLA Handbook (7th Edition):
Guridi Cortaberria, Andrea. “Genomotipificación de Camylobacter jejuni mediante microarrays de ADN
.” 2013. Web. 16 Jan 2021.
Vancouver:
Guridi Cortaberria A. Genomotipificación de Camylobacter jejuni mediante microarrays de ADN
. [Internet] [Doctoral dissertation]. Euskal Herriko Unibertsitatea / Universidad del País Vasco; 2013. [cited 2021 Jan 16].
Available from: http://hdl.handle.net/10810/10815.
Council of Science Editors:
Guridi Cortaberria A. Genomotipificación de Camylobacter jejuni mediante microarrays de ADN
. [Doctoral Dissertation]. Euskal Herriko Unibertsitatea / Universidad del País Vasco; 2013. Available from: http://hdl.handle.net/10810/10815
Victoria University of Wellington
26.
Hunt, Rachel.
Genetic Programming Hyper-heuristics for Job Shop Scheduling.
Degree: 2016, Victoria University of Wellington
URL: http://hdl.handle.net/10063/5219
► Scheduling problems arise whenever there is a choice of order in which a number of tasks should be performed; they arise commonly, daily and everywhere.…
(more)
▼ Scheduling problems arise whenever there is a choice of order in which a number of tasks should be performed; they arise commonly, daily and everywhere. A job shop is a common manufacturing environment in which a schedule for processing a set of jobs through a set of machines needs to be constructed. Job shop scheduling (JSS) has been called a fascinating challenge as it is computationally hard and prevalent in the real-world. Developing more effective ways of scheduling jobs could increase profitability through increasing throughput and decreasing costs. Dispatching rules (DRs) are one of the most popular scheduling heuristics. DRs are easy to implement, have low computational cost, and cope well with the dynamic nature of real-world manufacturing environments. However, the manual development of DRs is time consuming and requires expert knowledge of the scheduling environment. Genetic programming (GP) is an evolutionary computation method which is ideal for automatically discovering DRs. This is a
hyper-heuristic approach, as GP is searching the search space of heuristic (DR) solutions rather than constructing a schedule directly.
The overall goal of this thesis is to develop GP based
hyper-heuristics for the efficient evolution (automatic generation) of robust, reusable and effective scheduling heuristics for JSS environments, with greater interpretability.
Firstly, this thesis investigates using GP to evolve optimal DRs for the static two-machine JSS problem with makespan objective function. The results show that some evolved DRs were equivalent to an optimal scheduling algorithm. This validates both the GP based
hyper-heuristic approach for generating DRs for JSS and the representation used.
Secondly, this thesis investigates developing ``less-myopic'' DRs through the use of wider-looking terminals and local search to provide additional fitness information. The results show that incorporating features of the state of the wider shop improves the mean performance of the best evolved DRs, and that the inclusion of local search in evaluation evolves DRs which make better decisions over the local time horizon, and attain lower total weighted tardiness.
Thirdly, this thesis proposes using strongly typed GP (STGP) to address the challenging issue of interpretability of DRs evolved by GP. Several grammars are investigated and the results show that the DRs evolved in the semantically constrained search space of STGP do not have (on average) performance that is as good as unconstrained. However, the interpretability of evolved rules is substantially improved.
Fourthly, this thesis investigates using multiobjective GP to encourage evolution of DRs which are more readily interpretable by human operators. This approach evolves DRs with similar performance but smaller size. Fragment analysis identifies popular combinations of terminals which are then used as high level terminals; the inclusion of these terminals improved the mean performance of the best evolved DRs.
Through this thesis the following major…
Advisors/Committee Members: Zhang, Mengjie, Johnston, Mark.
Subjects/Keywords: Genetic Programming; Hyper-heuristics; Scheduling
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APA (6th Edition):
Hunt, R. (2016). Genetic Programming Hyper-heuristics for Job Shop Scheduling. (Doctoral Dissertation). Victoria University of Wellington. Retrieved from http://hdl.handle.net/10063/5219
Chicago Manual of Style (16th Edition):
Hunt, Rachel. “Genetic Programming Hyper-heuristics for Job Shop Scheduling.” 2016. Doctoral Dissertation, Victoria University of Wellington. Accessed January 16, 2021.
http://hdl.handle.net/10063/5219.
MLA Handbook (7th Edition):
Hunt, Rachel. “Genetic Programming Hyper-heuristics for Job Shop Scheduling.” 2016. Web. 16 Jan 2021.
Vancouver:
Hunt R. Genetic Programming Hyper-heuristics for Job Shop Scheduling. [Internet] [Doctoral dissertation]. Victoria University of Wellington; 2016. [cited 2021 Jan 16].
Available from: http://hdl.handle.net/10063/5219.
Council of Science Editors:
Hunt R. Genetic Programming Hyper-heuristics for Job Shop Scheduling. [Doctoral Dissertation]. Victoria University of Wellington; 2016. Available from: http://hdl.handle.net/10063/5219
University of Bath
27.
Ayten, Kagan Koray.
Optimum trajectory planning for redundant manipulators through inverse dynamics.
Degree: PhD, 2012, University of Bath
URL: https://researchportal.bath.ac.uk/en/studentthesis/optimum-trajectory-planning-for-redundant-manipulators-through-inverse-dynamics(f47bae7a-e3e2-4664-b392-c1e7eba0ea9b).html
;
https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.665377
► The purpose of this thesis is to develop methods to generate minimum-energy consumption trajectories for a point-to-point motion under pre-defined kinematic and dynamic constraints for…
(more)
▼ The purpose of this thesis is to develop methods to generate minimum-energy consumption trajectories for a point-to-point motion under pre-defined kinematic and dynamic constraints for robotic manipulators. With respect to other trajectory optimization methods, the work presented in this thesis provides two new methods to the scientific literature. The proposed methods improve the handling of the constraints in trajectory optimization methods as well as reducing the computational complexity of redundant/hyper-redundant manipulator systems.
Subjects/Keywords: 629.8; redundant; hyper-redundant; optimization
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APA ·
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APA (6th Edition):
Ayten, K. K. (2012). Optimum trajectory planning for redundant manipulators through inverse dynamics. (Doctoral Dissertation). University of Bath. Retrieved from https://researchportal.bath.ac.uk/en/studentthesis/optimum-trajectory-planning-for-redundant-manipulators-through-inverse-dynamics(f47bae7a-e3e2-4664-b392-c1e7eba0ea9b).html ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.665377
Chicago Manual of Style (16th Edition):
Ayten, Kagan Koray. “Optimum trajectory planning for redundant manipulators through inverse dynamics.” 2012. Doctoral Dissertation, University of Bath. Accessed January 16, 2021.
https://researchportal.bath.ac.uk/en/studentthesis/optimum-trajectory-planning-for-redundant-manipulators-through-inverse-dynamics(f47bae7a-e3e2-4664-b392-c1e7eba0ea9b).html ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.665377.
MLA Handbook (7th Edition):
Ayten, Kagan Koray. “Optimum trajectory planning for redundant manipulators through inverse dynamics.” 2012. Web. 16 Jan 2021.
Vancouver:
Ayten KK. Optimum trajectory planning for redundant manipulators through inverse dynamics. [Internet] [Doctoral dissertation]. University of Bath; 2012. [cited 2021 Jan 16].
Available from: https://researchportal.bath.ac.uk/en/studentthesis/optimum-trajectory-planning-for-redundant-manipulators-through-inverse-dynamics(f47bae7a-e3e2-4664-b392-c1e7eba0ea9b).html ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.665377.
Council of Science Editors:
Ayten KK. Optimum trajectory planning for redundant manipulators through inverse dynamics. [Doctoral Dissertation]. University of Bath; 2012. Available from: https://researchportal.bath.ac.uk/en/studentthesis/optimum-trajectory-planning-for-redundant-manipulators-through-inverse-dynamics(f47bae7a-e3e2-4664-b392-c1e7eba0ea9b).html ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.665377
University of Illinois – Urbana-Champaign
28.
Szuck, Matthew J.
Simulation of micro-shaped charge experiments and analysis of shock states for a hyper-elastic solid.
Degree: MS, 0133, 2011, University of Illinois – Urbana-Champaign
URL: http://hdl.handle.net/2142/24029
► This thesis focuses on shaped charge simulations using a hydro-code called ALE3D. It gives background on shaped charge research and motivation for the project itself…
(more)
▼ This thesis focuses on shaped charge simulations using a hydro-code called ALE3D.
It gives background on shaped charge research and motivation for the project itself
along with information on a shaped charge experiment that took place at the University
of Illinois Urbana Champaign. A baseline simulation is created to mock the experiment
and compare results. Next, a series of simulations are conducted varying parameters
such as HE, liner, and target material and analyzing output data. Then a second
proposed shaped charge experiment with different geometry and materials is simulated.
Finally a newer topic of asymmetrical defective shaped charges is explored by means of
simulations. It also advances on shock states for a
hyper-elastic solid using the Blatz-Ko
equilibrium relations and general conservation laws. Basic Rankine-Hugoniot relations
for longitudinal isotropic motion are determined. To further this topic, a study of
anisotropic materials was conducted using ALE3D.
Advisors/Committee Members: Stewart, Donald S. (advisor).
Subjects/Keywords: shaped charge; hyper-elastic solid
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APA ·
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Export
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APA (6th Edition):
Szuck, M. J. (2011). Simulation of micro-shaped charge experiments and analysis of shock states for a hyper-elastic solid. (Thesis). University of Illinois – Urbana-Champaign. Retrieved from http://hdl.handle.net/2142/24029
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Szuck, Matthew J. “Simulation of micro-shaped charge experiments and analysis of shock states for a hyper-elastic solid.” 2011. Thesis, University of Illinois – Urbana-Champaign. Accessed January 16, 2021.
http://hdl.handle.net/2142/24029.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Szuck, Matthew J. “Simulation of micro-shaped charge experiments and analysis of shock states for a hyper-elastic solid.” 2011. Web. 16 Jan 2021.
Vancouver:
Szuck MJ. Simulation of micro-shaped charge experiments and analysis of shock states for a hyper-elastic solid. [Internet] [Thesis]. University of Illinois – Urbana-Champaign; 2011. [cited 2021 Jan 16].
Available from: http://hdl.handle.net/2142/24029.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Szuck MJ. Simulation of micro-shaped charge experiments and analysis of shock states for a hyper-elastic solid. [Thesis]. University of Illinois – Urbana-Champaign; 2011. Available from: http://hdl.handle.net/2142/24029
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
29.
Bajenov, Alexandr V.
Biomorphic Hyper-Redundant Snake Robot: Design, Prototyping, and Locomotion Performance Demonstration.
Degree: 2018, University of Nevada – Reno
URL: http://hdl.handle.net/11714/4875
► This thesis focuses on the design, construction, and control of a roboticsnake. Relevant theoretical and practical aspects of the mechanical,electrical, and algorithmic design of the…
(more)
▼ This thesis focuses on the design, construction, and control of a roboticsnake. Relevant theoretical and practical aspects of the mechanical,electrical, and algorithmic design of the robot are described. Mechanically, therobot is a modular multi-segment mechanism, in which each segment is a 2-DOF (two degrees-of-freedom) universal joint driven by two motors. Most ofthe structural and mechancal parts were designed in Solidworks and 3D-printed, while others were standard off-the-shelf components such as screwsand bearings. The motors are RC servo motors. The angular displacementcommand for each servo motor is calculated by a central pattern generatorfrom a vector of motion parameters. These parameters are transmittedwirelessly from a handheld device to the robot. By varying the motionparameters, the robot is capable of several modes of locomotion, includingslithering forward or in reverse, steering to either side, rolling sideways, orside-winding sideways.
Advisors/Committee Members: Shen, Yantao (advisor), Fadali, M. Sami (committee member), Alexis, Kostas (committee member).
Subjects/Keywords: biomimetic; hyper-redundant; robot; snake
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APA ·
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APA (6th Edition):
Bajenov, A. V. (2018). Biomorphic Hyper-Redundant Snake Robot: Design, Prototyping, and Locomotion Performance Demonstration. (Thesis). University of Nevada – Reno. Retrieved from http://hdl.handle.net/11714/4875
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Bajenov, Alexandr V. “Biomorphic Hyper-Redundant Snake Robot: Design, Prototyping, and Locomotion Performance Demonstration.” 2018. Thesis, University of Nevada – Reno. Accessed January 16, 2021.
http://hdl.handle.net/11714/4875.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Bajenov, Alexandr V. “Biomorphic Hyper-Redundant Snake Robot: Design, Prototyping, and Locomotion Performance Demonstration.” 2018. Web. 16 Jan 2021.
Vancouver:
Bajenov AV. Biomorphic Hyper-Redundant Snake Robot: Design, Prototyping, and Locomotion Performance Demonstration. [Internet] [Thesis]. University of Nevada – Reno; 2018. [cited 2021 Jan 16].
Available from: http://hdl.handle.net/11714/4875.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Bajenov AV. Biomorphic Hyper-Redundant Snake Robot: Design, Prototyping, and Locomotion Performance Demonstration. [Thesis]. University of Nevada – Reno; 2018. Available from: http://hdl.handle.net/11714/4875
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
30.
Sreelakshmi, B.
Molecular Approaches For Characterization And Determination Of Pathogenicity Of Vibrios With Special Reference To Vibrio Harveyi From Penaeus Monodon Larval Production Systems.
Degree: 2011, Cochin University of Science and Technology
URL: http://dyuthi.cusat.ac.in/purl/3697
► The present study focuses on vibrios especially Vibrio harveyi isolated from shrimp (P. monodon) larval production systems from both east and west coasts during times…
(more)
▼ The present study focuses on vibrios especially Vibrio harveyi
isolated from shrimp (P. monodon) larval production systems from both east
and west coasts during times of mortality. A comprehensive approach has
been made to work out their systematics through numerical taxonomy and
group them based on RAPD profiling and to segregate the virulent from
non- virulent isolates based on the presence of virulent genes as well as their
phenotypic expression. The information gathered has helped to develop a
simple scheme of identification based on phenotypic characters and
segregate the virulent from non virulent strains of V. harveyi.
National Centre for Aquatic Animal Health
Cochin University of Science and
Technology
Cochin University of Science and
Technology
Subjects/Keywords: Taxonomy of vibrios; Evolution of vibrios; Bacterial Adaptation; Virulent factors of Vibrios; Shellfish health management
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APA ·
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MLA ·
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APA (6th Edition):
Sreelakshmi, B. (2011). Molecular Approaches For Characterization And Determination Of Pathogenicity Of Vibrios With Special Reference To Vibrio Harveyi From Penaeus Monodon Larval Production Systems. (Thesis). Cochin University of Science and Technology. Retrieved from http://dyuthi.cusat.ac.in/purl/3697
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Sreelakshmi, B. “Molecular Approaches For Characterization And Determination Of Pathogenicity Of Vibrios With Special Reference To Vibrio Harveyi From Penaeus Monodon Larval Production Systems.” 2011. Thesis, Cochin University of Science and Technology. Accessed January 16, 2021.
http://dyuthi.cusat.ac.in/purl/3697.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Sreelakshmi, B. “Molecular Approaches For Characterization And Determination Of Pathogenicity Of Vibrios With Special Reference To Vibrio Harveyi From Penaeus Monodon Larval Production Systems.” 2011. Web. 16 Jan 2021.
Vancouver:
Sreelakshmi B. Molecular Approaches For Characterization And Determination Of Pathogenicity Of Vibrios With Special Reference To Vibrio Harveyi From Penaeus Monodon Larval Production Systems. [Internet] [Thesis]. Cochin University of Science and Technology; 2011. [cited 2021 Jan 16].
Available from: http://dyuthi.cusat.ac.in/purl/3697.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Sreelakshmi B. Molecular Approaches For Characterization And Determination Of Pathogenicity Of Vibrios With Special Reference To Vibrio Harveyi From Penaeus Monodon Larval Production Systems. [Thesis]. Cochin University of Science and Technology; 2011. Available from: http://dyuthi.cusat.ac.in/purl/3697
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
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Open Access Theses and Dissertations
