You searched for subject:(Hydrocortisone).
Showing records 1 – 30 of
129 total matches.
◁ [1] [2] [3] [4] [5] ▶
Oregon State University
1.
Le, Hang Thi.
Hydrocortisone permeation study using a synthetic membrane, mouse skin and an epiderm cultured skin.: Preparation of orally disintegrating tablets of melatonin and acetaminophen.
Degree: PhD, Pharmacy, 2008, Oregon State University
URL: http://hdl.handle.net/1957/9296 
► The first project of this thesis is an in vitro study. This study was performed with 8 hydrocortisone topical products on the market for the…
(more)
▼ The first project of this thesis is an in vitro study. This study was performed with 8
hydrocortisone topical products on the market for the purpose of comparing one Tec Lab product, a Corticool gel, to the other seven common products on the market. The permeation of these products was tested with three types of membranes: a synthetic membrane, a mouse skin, and an EpidermTM using a Franz Cell apparatus. The synthetic membrane seemed to over-estimate the
hydrocortisone permeation through the skin. Mouse skin has a higher permeation compared to human cultured skin, EpidermTM. Corticool gel (1%
hydrocortisone), which has a higher
hydrocortisone solubility compared to other creams and lotions, showed a significantly higher drug diffusion rate through all of the three membranes. The Corticool gel exhibited better
hydrocortisone permeation than the Prescription
hydrocortisone cream 2.5%. Cortizone-10 ointment (1%
hydrocortisone) showed a very low
hydrocortisone permeation through all of the three membranes. It is predicted that the same comparative behavior would be observed in vivo on applying these formulations. Corticool gel is suggested to be used for fast action treatment.
The second project related to a preparation of orally disintegrating tablets of melatonin and orally disintegrating tablets containing sustained-release beads of acetaminophen. A combination of superdisintegrants, amino acids, effervescent materials, and sweeteners was placed into a melatonin tablet and then compressed into a normal-shaped tablet. The melatonin tablet exhibited a short disintegration time in water, had adequate hardness, and passed the friability test. This tablet also tasted good and could be used for children and vulnerable subjects having difficulty in swallowing.
The acetaminophen tablet combines two desirable properties: fast disintegration and sustained release of the drug. Acetaminophen sustained-release beads were added inside the tablet. The tablet disintegrated very quickly in water to release the sustained-release beads. By using hydrophilic polymers (HPMC and polyethylene oxide), the sustained release beads were protected and the sustained-release properties maintained. Similar excipients to those used in the melatonin tablet were used as excipients in the acetaminophen tablet to obtain fast tablet disintegration. A higher pressure was needed to combine beads and other excipients surrounding the beads into tablets. The tablets also had longer disintegration times but were still considered fast disintegrating tablets.
The third project is a pharmacokinetic study of terbinafine in penguins aiming at treatment aspergillosis. Terbinafine was administered orally by single dosing and multiple dosing to African penguins (Spheniscus demersus). The pharmacokinetics parameters were calculated. The best-fitted model, a two-compartment open model with a deep-tissue elimination phase, was selected. A recommended dose also was calculated to treat fungal infections in penguins.
Advisors/Committee Members: James, Ayres W. (advisor), Proteau, Rosita R. (committee member).
Subjects/Keywords: hydrocortisone; Hydrocortisone – Absorption and adsorption
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Le, H. T. (2008). Hydrocortisone permeation study using a synthetic membrane, mouse skin and an epiderm cultured skin.: Preparation of orally disintegrating tablets of melatonin and acetaminophen. (Doctoral Dissertation). Oregon State University. Retrieved from http://hdl.handle.net/1957/9296
Chicago Manual of Style (16th Edition):
Le, Hang Thi. “Hydrocortisone permeation study using a synthetic membrane, mouse skin and an epiderm cultured skin.: Preparation of orally disintegrating tablets of melatonin and acetaminophen.” 2008. Doctoral Dissertation, Oregon State University. Accessed January 19, 2021.
http://hdl.handle.net/1957/9296.
MLA Handbook (7th Edition):
Le, Hang Thi. “Hydrocortisone permeation study using a synthetic membrane, mouse skin and an epiderm cultured skin.: Preparation of orally disintegrating tablets of melatonin and acetaminophen.” 2008. Web. 19 Jan 2021.
Vancouver:
Le HT. Hydrocortisone permeation study using a synthetic membrane, mouse skin and an epiderm cultured skin.: Preparation of orally disintegrating tablets of melatonin and acetaminophen. [Internet] [Doctoral dissertation]. Oregon State University; 2008. [cited 2021 Jan 19].
Available from: http://hdl.handle.net/1957/9296.
Council of Science Editors:
Le HT. Hydrocortisone permeation study using a synthetic membrane, mouse skin and an epiderm cultured skin.: Preparation of orally disintegrating tablets of melatonin and acetaminophen. [Doctoral Dissertation]. Oregon State University; 2008. Available from: http://hdl.handle.net/1957/9296
Oregon State University
2.
Voller, Bernadette E.
Cortisol, pregnene and pregnane profiles in normal and dysmature newborn pony and lighthorse foals.
Degree: MS, Animal Science, 1993, Oregon State University
URL: http://hdl.handle.net/1957/36096
Subjects/Keywords: Hydrocortisone
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Voller, B. E. (1993). Cortisol, pregnene and pregnane profiles in normal and dysmature newborn pony and lighthorse foals. (Masters Thesis). Oregon State University. Retrieved from http://hdl.handle.net/1957/36096
Chicago Manual of Style (16th Edition):
Voller, Bernadette E. “Cortisol, pregnene and pregnane profiles in normal and dysmature newborn pony and lighthorse foals.” 1993. Masters Thesis, Oregon State University. Accessed January 19, 2021.
http://hdl.handle.net/1957/36096.
MLA Handbook (7th Edition):
Voller, Bernadette E. “Cortisol, pregnene and pregnane profiles in normal and dysmature newborn pony and lighthorse foals.” 1993. Web. 19 Jan 2021.
Vancouver:
Voller BE. Cortisol, pregnene and pregnane profiles in normal and dysmature newborn pony and lighthorse foals. [Internet] [Masters thesis]. Oregon State University; 1993. [cited 2021 Jan 19].
Available from: http://hdl.handle.net/1957/36096.
Council of Science Editors:
Voller BE. Cortisol, pregnene and pregnane profiles in normal and dysmature newborn pony and lighthorse foals. [Masters Thesis]. Oregon State University; 1993. Available from: http://hdl.handle.net/1957/36096
Brigham Young University
3.
Wells, Aaron M.
The Effects of Low Frequency Ultrasound in Transdermal Drug Delivery.
Degree: PhD, 2010, Brigham Young University
URL: https://scholarsarchive.byu.edu/cgi/viewcontent.cgi?article=3559&context=etd
► Objective: Determine if varying ultrasound frequency affects the delivery of 10% hydrocortisone concentrations during phonophoresis. Utilize intramuscular microdialysis probe for drug collection, thus improving…
(more)
▼ Objective: Determine if varying ultrasound frequency affects the delivery of 10% hydrocortisone concentrations during phonophoresis. Utilize intramuscular microdialysis probe for drug collection, thus improving the experimental model. Methods: Thirty one (10 in groups 1 and 2, 11 in group 3) healthy subjects participated in this study. Interventions: Subjects were randomly assigned to one of three treatment groups receiving 10 minute ultrasound treatments applied to a standardized area of the gastrocnemius muscle of the right leg. The ultrasound was performed over the treated area using a 10% hydrocortisone compound mixed with standard ultrasound gel. The contralateral limb served as the control (no mixed compound or treatment) for all groups. Group one received sham ultrasound. Medicated gel was placed on the treatment site, the sound head moved, but no ultrasound was applied. Group two received 45 KHz at .056 w/cm2. Group three received 1 MHz at 1.0 w/cm2 at a 50 % duty cycle. Results: There was no difference in cortisol concentration change during treatment between the three treatment groups on the treated limbs (sham = 1.1 ±7.5 ng/ml, 45 KHz = 1.1 ± 1.5 ng/ml, 1 MHz = 4.1 ± 7.8 ng/ml; F2,22 = .34, P = .72) or control limbs (sham = 1.65 ± 6.6 ng/ml, 45 KHz = -1.3 ± 2.7 ng/ml, 1 MHz = 0.37 ± 8.1 ng/ml; F2,22 = .67, P = .546). No difference was found in cortisol concentration change during treatment between the treatment limbs and the control limbs (treatment = 2.1 ± 6.2 ng/ml, control = 0.20 ± 5.9 ng/ml; F1,22 = .9, P = .35). The following factors were found to influence cortisol concentrations levels in dialysate collected during treatment: depth of muscle in the treatment limbs (F1,22 = 6.4, P = .02), microdialysis probe depth in the control limbs (F1,22 = 4.1, P = .05), and pre treatment cortisol level in the control limbs (F1,22 = 10.1, P = .004. Conclusions: There was no evidence altering ultrasound frequency from 45 KHz to 1 MHZ enhanced the delivery of 10% hydrocortisone to treatment tissues under these experimental conditions.
Subjects/Keywords: microdialysis; 10% hydrocortisone; Exercise Science
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Wells, A. M. (2010). The Effects of Low Frequency Ultrasound in Transdermal Drug Delivery. (Doctoral Dissertation). Brigham Young University. Retrieved from https://scholarsarchive.byu.edu/cgi/viewcontent.cgi?article=3559&context=etd
Chicago Manual of Style (16th Edition):
Wells, Aaron M. “The Effects of Low Frequency Ultrasound in Transdermal Drug Delivery.” 2010. Doctoral Dissertation, Brigham Young University. Accessed January 19, 2021.
https://scholarsarchive.byu.edu/cgi/viewcontent.cgi?article=3559&context=etd.
MLA Handbook (7th Edition):
Wells, Aaron M. “The Effects of Low Frequency Ultrasound in Transdermal Drug Delivery.” 2010. Web. 19 Jan 2021.
Vancouver:
Wells AM. The Effects of Low Frequency Ultrasound in Transdermal Drug Delivery. [Internet] [Doctoral dissertation]. Brigham Young University; 2010. [cited 2021 Jan 19].
Available from: https://scholarsarchive.byu.edu/cgi/viewcontent.cgi?article=3559&context=etd.
Council of Science Editors:
Wells AM. The Effects of Low Frequency Ultrasound in Transdermal Drug Delivery. [Doctoral Dissertation]. Brigham Young University; 2010. Available from: https://scholarsarchive.byu.edu/cgi/viewcontent.cgi?article=3559&context=etd
Brigham Young University
4.
Webb, Patrick Thomas.
The Pre-Application of Hydrocortisone Cream and Its Effect on Transdermal Drug Delivery by Phonophoresis.
Degree: MS, 2012, Brigham Young University
URL: https://scholarsarchive.byu.edu/cgi/viewcontent.cgi?article=4934&context=etd
► Context: Transdermal delivery of hydrocortisone by phonophoresis is used for the treatment of musculoskeletal conditions. Research shows hydrocortisone and other white or opaque topical preparations…
(more)
▼ Context: Transdermal delivery of hydrocortisone by phonophoresis is used for the treatment of musculoskeletal conditions. Research shows hydrocortisone and other white or opaque topical preparations transmit ultrasound energy poorly. Effective transmission of ultrasound is important in phonophoresis. Main Outcome measured: Samples of subcutaneous interstitial fluid were collected during and for 20 minutes following phonophoresis treatment. Cortisol concentrations were analyzed by an enzyme linked immune-assay (ELISA) test. Objective: Determine the subcutaneous cortisol concentration after two different phonophoresis treatments using a 2.5% hydrocortisone preparation. Design: Randomized design in which 22 healthy participants were assigned to receive a phonophoresis treatment where: 1) hydrocortisone cream was rubbed in completely prior to phonophoresis or 2) hydrocortisone powder was compounded with an ultrasound coupling gel. Test Subjects: 22 healthy individuals were recruited: 13 females with a mean age of 21 years and 9 males with a mean age of 21.8 years. Intervention: Phonophoresis consisted of pulsed ultrasound at 1 MHz, 1.0 w/cm2, and a 50% duty cycle. The treatment duration was 10 minutes and was localized over the distal gastrocnemius muscle. Results: We observed no significant difference in subcutaneous cortisol concentration between the two phonophoresis treatments (p=0.05). Also no significant difference was detected between pre and post-treatment cortisol levels within each individual treatment group. Conclusions: Our data indicates that completely rubbing a topical hydrocortisone application into the skin prior to placement of ultrasound gel does not result in increased transdermal delivery of cortisol when compared with the use of a compound of ultrasound gel and hydrocortisone powder applied topically to the skin.
Subjects/Keywords: phonophoresis; hydrocortisone; microdialysis; Exercise Science
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Webb, P. T. (2012). The Pre-Application of Hydrocortisone Cream and Its Effect on Transdermal Drug Delivery by Phonophoresis. (Masters Thesis). Brigham Young University. Retrieved from https://scholarsarchive.byu.edu/cgi/viewcontent.cgi?article=4934&context=etd
Chicago Manual of Style (16th Edition):
Webb, Patrick Thomas. “The Pre-Application of Hydrocortisone Cream and Its Effect on Transdermal Drug Delivery by Phonophoresis.” 2012. Masters Thesis, Brigham Young University. Accessed January 19, 2021.
https://scholarsarchive.byu.edu/cgi/viewcontent.cgi?article=4934&context=etd.
MLA Handbook (7th Edition):
Webb, Patrick Thomas. “The Pre-Application of Hydrocortisone Cream and Its Effect on Transdermal Drug Delivery by Phonophoresis.” 2012. Web. 19 Jan 2021.
Vancouver:
Webb PT. The Pre-Application of Hydrocortisone Cream and Its Effect on Transdermal Drug Delivery by Phonophoresis. [Internet] [Masters thesis]. Brigham Young University; 2012. [cited 2021 Jan 19].
Available from: https://scholarsarchive.byu.edu/cgi/viewcontent.cgi?article=4934&context=etd.
Council of Science Editors:
Webb PT. The Pre-Application of Hydrocortisone Cream and Its Effect on Transdermal Drug Delivery by Phonophoresis. [Masters Thesis]. Brigham Young University; 2012. Available from: https://scholarsarchive.byu.edu/cgi/viewcontent.cgi?article=4934&context=etd
University of Hawaii
5.
Cornette-Finn, Kuuleialoha M.
ADH response to peripheral and central cortisol administration.
Degree: 2009, University of Hawaii
URL: http://hdl.handle.net/10125/9435
► Typescript.
Bibliography: leaves 135-147.
Photocopy.
Microfilm.
xiv, 147 leaves, bound ill. 29 cm
Cortisol affects water balance, but whether this effect is mediated through antidiuretic…
(more)
▼ Typescript.
Bibliography: leaves 135-147.
Photocopy.
Microfilm.
xiv, 147 leaves, bound ill. 29 cm
Cortisol affects water balance, but whether this effect is mediated through antidiuretic hormone (ADH) is unclear. This study examines the response of plasma ADH (pADH) in two groups of conscious dogs; one received cortisol centrally (ivt) in the third ventricle at 300 ng/min, the other peripherally (iv) at 4.16 µg/kg/min, in 4 states of water balance, i.e., dehydration, normal hydration, 5% NaCl iv infusion (0.05 ml/kg/min), and after a water load (40 ml/kg given iv over 30 min), as compared to control experiments without cortisol. Cortisol, either ivt or iv, had no affect on pADH or plasma osmolality (pOsm) during dehydration or normal hydration. Ivt cortisol infusion caused a progressive decline in plasma cortisol (pCort) while iv cortisol infusion increased pCort (control 2.0 µg%, ivt pCort 0.5 µg%, iv pCort 17 µg%, P<0.01). During the 5% NaCl iv infusion, pADH and pOsm increased similarly in both the control and ivt cortisol experiments from 1.0 to 1.9 µU/ml and 295 to 305 mOsm/kg H2O, respectively (P<0.01). The increase in pADH seen with 5% NaCl infusion was delayed in the iv cortisol experiment as compared to the iv control (75 min versus 45 min, P<0.01). This delay was also seen in pOsm; 45 min in iv cortisol versus 15 min in iv control (P<0.01), indicating that the elevated pCort apparently delays the development of increased pOsm and the subsequent increase in pADH. During a water load, the cumulative urine excreted was 99% of that ingested with iv cortisol (P<0.05), 82% in the control, and 70% with ivt cortisol; in all three cases similar decreases in pADH and pOsm occurred. The free water clearance (FWC) was augmented in the iv cortisol infusion and attenuated in the opposite situation of pCort insufficiency which was established during the ivt cortisol infusion. Thus, the present study demonstrates that cortisol has a peripheral effect in that elevated plasma cortisol 1) delays the rise in pOsm during hypertonic saline infusion 2) increases FWC during a water diuresis but 3) does not alter the pADH versus pOsm relationship, therefore 4) affects the ability to excrete a water load independent of ADH. These data are compatible with a mechanism in which excess cortisol enhances the Na+ "leak" pathway of the cells by increasing the membrane permeability to Na+, thereby increasing the osmolar content of the cells.
Subjects/Keywords: Vasopressin; Hydrocortisone
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Cornette-Finn, K. M. (2009). ADH response to peripheral and central cortisol administration. (Thesis). University of Hawaii. Retrieved from http://hdl.handle.net/10125/9435
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Cornette-Finn, Kuuleialoha M. “ADH response to peripheral and central cortisol administration.” 2009. Thesis, University of Hawaii. Accessed January 19, 2021.
http://hdl.handle.net/10125/9435.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Cornette-Finn, Kuuleialoha M. “ADH response to peripheral and central cortisol administration.” 2009. Web. 19 Jan 2021.
Vancouver:
Cornette-Finn KM. ADH response to peripheral and central cortisol administration. [Internet] [Thesis]. University of Hawaii; 2009. [cited 2021 Jan 19].
Available from: http://hdl.handle.net/10125/9435.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Cornette-Finn KM. ADH response to peripheral and central cortisol administration. [Thesis]. University of Hawaii; 2009. Available from: http://hdl.handle.net/10125/9435
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of British Columbia
6.
Haugen, Frances Patricia.
An evaluation of rheological parameters for a model shear-thinning system with application to the diffusion of hydrocortisone.
Degree: PhD, Pharmaceutical Sciences, 1974, University of British Columbia
URL: http://hdl.handle.net/2429/19719
► Many pharmaceutical systems exhibit shear-thinning flow properties but the expression of these properties in terms of meaningful rheological parameters remains a problem. To be useful,…
(more)
▼ Many pharmaceutical systems exhibit shear-thinning flow properties but the expression of these properties in terms of meaningful rheological parameters remains a problem. To be useful, the parameters must be rheometer-independent and either describe the fluid under application, processing and storage conditions, or specify the fluid structure and disposition of the molecules at negligible shear rates. Interlinked with this problem is the correct selection of rheological parameters and systems for applied studies, i.e. the determination of rheological effects on drug diffusion.
The components of the model shear-thinning system, the nonionic cellulose polymer, hydroxyethylcellulose (HEC, Natrosol 250G), and the nonionic surfactant, polyoxyethylene (4) dodecyl ether (Brij 30), were characterized, physicochemically. The addition of Brij 30 to HEC dispersions provided a reliable means of obtaining a series of systems showing predictable increments in shear-thinning behaviour at each HEC concentration.
Over a 5 year period, the rheological reproducibility and stability of aqueous HEC dispersions were determined and compared with corresponding data for 2% methylcellulose (MC, 1500 cP) dispersions. For similar consistencies, HEC and MC dispersions showed comparable reproducibility and stability. The power-law consistency index was observed to be related to both storage time and polymer concentration.
Two methods of shear stress calibration were examined for the Rotovisko. The determination of a shear stress calibration constant for each shear rate provided a significant improvement for non-Newtonian shear-thinning fluids over the manufacturer's calibration method when both methods were compared with corresponding data generated with the
cone-plate Weissenberg rheogoniometer.
The limitations of shear rate equations and two Couette rheometers, Haake Rotovisko and Brookfield Synchro-lectric (with SC-4 spindles), to accurately represent shear stress-shear rate parameters were examined. The Krieger-Maron and the Mooney shear rate equations were found to yield the widest range of rheometer-independent results for the Rotovisko and Brookfield rheometers, respectively, when separately compared with similar data obtained with the rheogoniometer.
Viscometric properties of polyoxyethylene (4) dodecyl ether in HEC dispersions were evaluated over a concentration range of 2.0 -3.5% HEC and 0 - 16% Brij 30. Three rheological models: the modified Shangraw structure equation, the Steiger-Trippi-Ory equation and the power-law model were fitted to the data and found to describe accurately the flow behaviour of the dispersions at 30.0°C between shear rates of 8.5 - 685 s⁻¹. Variation of model parameters with surfactant concentration was computed for each HEC dispersion. A shear-sensitive interaction between the surfactant and the cellulose polymer was noted.
To determine the disposition of HEC in solution and the nature of the viscous interaction noted for the HEC - Brij 30 systems, low shear rate and dynamic measurements were made.…
Subjects/Keywords: Rheology; Hydrocortisone
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Haugen, F. P. (1974). An evaluation of rheological parameters for a model shear-thinning system with application to the diffusion of hydrocortisone. (Doctoral Dissertation). University of British Columbia. Retrieved from http://hdl.handle.net/2429/19719
Chicago Manual of Style (16th Edition):
Haugen, Frances Patricia. “An evaluation of rheological parameters for a model shear-thinning system with application to the diffusion of hydrocortisone.” 1974. Doctoral Dissertation, University of British Columbia. Accessed January 19, 2021.
http://hdl.handle.net/2429/19719.
MLA Handbook (7th Edition):
Haugen, Frances Patricia. “An evaluation of rheological parameters for a model shear-thinning system with application to the diffusion of hydrocortisone.” 1974. Web. 19 Jan 2021.
Vancouver:
Haugen FP. An evaluation of rheological parameters for a model shear-thinning system with application to the diffusion of hydrocortisone. [Internet] [Doctoral dissertation]. University of British Columbia; 1974. [cited 2021 Jan 19].
Available from: http://hdl.handle.net/2429/19719.
Council of Science Editors:
Haugen FP. An evaluation of rheological parameters for a model shear-thinning system with application to the diffusion of hydrocortisone. [Doctoral Dissertation]. University of British Columbia; 1974. Available from: http://hdl.handle.net/2429/19719
7.
Hamitouche, Noureddine.
Modélisation pharmacocinétique - pharmacodynamique de la fludrocotisone par approche de population : Population pharmacokinetic - pharmacodynamic modeling of fludrocortisone.
Degree: Docteur es, Biologie et sciences de la santé, 2017, Rennes 1
URL: http://www.theses.fr/2017REN1B026
► Introduction. Les corticoïdes sont supposés avoir des effets bénéfiques à faibles doses chez les patients en choc septique réfractaire. Ces effets ont été retrouvés dans…
(more)
▼ Introduction. Les corticoïdes sont supposés avoir des effets bénéfiques à faibles doses chez les patients en choc septique réfractaire. Ces effets ont été retrouvés dans plusieurs études utilisant l’hydrocortisone. Mais des données similaires n’existent cependant pas pour la fludrocortisone. Pourtant, l’hypothèse est que ces effets seraient liés en partie à l’action minéralocorticoïde. Or, la fludrocortisone est considérée comme un puissant minéralocorticoïde. Avant une éventuelle évaluation de la fludrocortisone chez les patients en choc septique, il est nécessaire dans un premier temps d’étudier sa pharmacocinétique (PK) et sa relation pharmacocinétique-pharmacodynamique (PK-PD) afin de mieux cerner ses effets et de sélectionner sa posologie efficace. Méthodes. Pour répondre aux objectifs, plusieurs travaux ont été réalisés. La modélisation en pharmacométrie par approche de population a été utilisée dans ces travaux pour caractériser la PK et la relation PK-PD de la fludrocortisone chez des volontaires sains après administration unique et répétée et la PK chez les patients en choc septique. Résultats. Chez les volontaires sains en administration unique seule ou en association avec l’hydrocortisone, la fludrocortisone a montré une demi-vie courte et proche de celle de l’hydrocortisone. Par ailleurs, la fludrocortisone présentait une puissance de l’effet minéralocorticoïde environ 200 fois plus importante que celle de l’hydrocortisone. Les simulations ont montré que la fludrocortisone nécessiterait d’être administrée à raison de quatre fois par jour. Chez les patients en choc septique, l’absorption de la fludrocortisone était très variable (7/21 des patients n’absorbaient pas la molécule) ce qui suggérait la nécessité de mettre au point une forme administrable par voie intraveineuse. A nouveau chez les volontaires sains mais en administration répétée pendant plusieurs jours, la fludrocortisone a montré une demi-vie et des paramètres pharmacocinétiques semblables à ceux retrouvés lors de la première étude et sur le plan pharmacodynamique, des effets hémodynamiques favorables (sur la réactivité vasculaire, la pression artérielle…) montrés pour la première fois avec cette molécule. Conclusion. La fludrocortisone a montré qu’elle pouvait induire les effets biologiques et hémodynamiques recherchés. Les effets hémodynamiques sur la réactivité vasculaire et la pression artérielle ont été observés après une imprégnation de 5 jours d’administration répétée de la fludrocortisone notamment avec la dose de 400 µg/jour. Une évaluation de l’efficacité de la fludrocortisone chez les patients en choc septique et maintenant envisageable et nécessaire pour confirmer les résultats obtenus.
Introduction. Low doses of corticosteroids showed beneficial effects in septic shock patients. These favorable effects may be partly result from the stimulation of the mineralocorticoid receptors. This finding has led us to explore the pharmacokinetic and the effects on hemodynamic and biologic parameters of fludrocortisone which is a potent…
Advisors/Committee Members: Laviolle, Bruno (thesis director), Bellissant, Éric (thesis director).
Subjects/Keywords: Fludrocortisone; Hydrocortisone; Pharmacocinétique; Pharmacodynamique; Fludrocortisone; Hydrocortisone; Pharmacokinetic; Pharmacodynamic
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Hamitouche, N. (2017). Modélisation pharmacocinétique - pharmacodynamique de la fludrocotisone par approche de population : Population pharmacokinetic - pharmacodynamic modeling of fludrocortisone. (Doctoral Dissertation). Rennes 1. Retrieved from http://www.theses.fr/2017REN1B026
Chicago Manual of Style (16th Edition):
Hamitouche, Noureddine. “Modélisation pharmacocinétique - pharmacodynamique de la fludrocotisone par approche de population : Population pharmacokinetic - pharmacodynamic modeling of fludrocortisone.” 2017. Doctoral Dissertation, Rennes 1. Accessed January 19, 2021.
http://www.theses.fr/2017REN1B026.
MLA Handbook (7th Edition):
Hamitouche, Noureddine. “Modélisation pharmacocinétique - pharmacodynamique de la fludrocotisone par approche de population : Population pharmacokinetic - pharmacodynamic modeling of fludrocortisone.” 2017. Web. 19 Jan 2021.
Vancouver:
Hamitouche N. Modélisation pharmacocinétique - pharmacodynamique de la fludrocotisone par approche de population : Population pharmacokinetic - pharmacodynamic modeling of fludrocortisone. [Internet] [Doctoral dissertation]. Rennes 1; 2017. [cited 2021 Jan 19].
Available from: http://www.theses.fr/2017REN1B026.
Council of Science Editors:
Hamitouche N. Modélisation pharmacocinétique - pharmacodynamique de la fludrocotisone par approche de population : Population pharmacokinetic - pharmacodynamic modeling of fludrocortisone. [Doctoral Dissertation]. Rennes 1; 2017. Available from: http://www.theses.fr/2017REN1B026
University of Georgia
8.
Brown, Chandra Demona.
A method of sampling a finished semisolid dosage form.
Degree: 2014, University of Georgia
URL: http://hdl.handle.net/10724/29500
► Several methods for removing samples from finished semisolid dosage forms are in current use. Sampling methods for semisolids vary among industry, but no standard method…
(more)
▼ Several methods for removing samples from finished semisolid dosage forms are in current use. Sampling methods for semisolids vary among industry, but no standard method exists. These methods are tailored to specific formulations and
manufacturers. This creates the possibility for differences in the determination of in vitro release specification, batch variability and stability profiles. The present study evaluates a standard method that will minimize variability in sampling, which
will enhance the performance testing of semisolids.
Subjects/Keywords: Hydrocortisone; Finished Semisolid; Sampling method; HPLC
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Brown, C. D. (2014). A method of sampling a finished semisolid dosage form. (Thesis). University of Georgia. Retrieved from http://hdl.handle.net/10724/29500
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Brown, Chandra Demona. “A method of sampling a finished semisolid dosage form.” 2014. Thesis, University of Georgia. Accessed January 19, 2021.
http://hdl.handle.net/10724/29500.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Brown, Chandra Demona. “A method of sampling a finished semisolid dosage form.” 2014. Web. 19 Jan 2021.
Vancouver:
Brown CD. A method of sampling a finished semisolid dosage form. [Internet] [Thesis]. University of Georgia; 2014. [cited 2021 Jan 19].
Available from: http://hdl.handle.net/10724/29500.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Brown CD. A method of sampling a finished semisolid dosage form. [Thesis]. University of Georgia; 2014. Available from: http://hdl.handle.net/10724/29500
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Central Connecticut State University
9.
Ngu, Tuong, 1988-.
Hydrocortisone acting as an inhibitor of GABA receptor in the red crayfish (Procambarus clarkii) muscle receptor organ.
Degree: Department of Biological Sciences, 2016, Central Connecticut State University
URL: http://content.library.ccsu.edu/u?/ccsutheses,2360
"Submitted in Partial Fulfillment of the Requirements for the Degree of Master of Science in Biological Science with Health Specialization."; Thesis advisor: Mark Jackson.; M.S.,Central Connecticut State University,,2016.;
Advisors/Committee Members: Jackson, Mark E.Subjects/Keywords: Hydrocortisone.; GABA – Receptors.; Procambarus clarkii.; Muscle receptors.
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Ngu, Tuong, 1. (2016). Hydrocortisone acting as an inhibitor of GABA receptor in the red crayfish (Procambarus clarkii) muscle receptor organ. (Thesis). Central Connecticut State University. Retrieved from http://content.library.ccsu.edu/u?/ccsutheses,2360
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Ngu, Tuong, 1988-. “Hydrocortisone acting as an inhibitor of GABA receptor in the red crayfish (Procambarus clarkii) muscle receptor organ.” 2016. Thesis, Central Connecticut State University. Accessed January 19, 2021.
http://content.library.ccsu.edu/u?/ccsutheses,2360.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Ngu, Tuong, 1988-. “Hydrocortisone acting as an inhibitor of GABA receptor in the red crayfish (Procambarus clarkii) muscle receptor organ.” 2016. Web. 19 Jan 2021.
Vancouver:
Ngu, Tuong 1. Hydrocortisone acting as an inhibitor of GABA receptor in the red crayfish (Procambarus clarkii) muscle receptor organ. [Internet] [Thesis]. Central Connecticut State University; 2016. [cited 2021 Jan 19].
Available from: http://content.library.ccsu.edu/u?/ccsutheses,2360.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Ngu, Tuong 1. Hydrocortisone acting as an inhibitor of GABA receptor in the red crayfish (Procambarus clarkii) muscle receptor organ. [Thesis]. Central Connecticut State University; 2016. Available from: http://content.library.ccsu.edu/u?/ccsutheses,2360
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Bath
10.
Bosela, Ahmed Abdalla.
The effect of gamma-radiation on hydrocortisone in solutions and topical preparations.
Degree: PhD, 1987, University of Bath
URL: https://researchportal.bath.ac.uk/en/studentthesis/the-effect-of-gammaradiation-on-hydrocortisone-in-solutions-and-topical-preparations(a181f1a9-e30a-43f1-b9f8-8127b0a68f2b).html
;
https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.377371
Subjects/Keywords: 615.1; Hydrocortisone sterilisation
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Bosela, A. A. (1987). The effect of gamma-radiation on hydrocortisone in solutions and topical preparations. (Doctoral Dissertation). University of Bath. Retrieved from https://researchportal.bath.ac.uk/en/studentthesis/the-effect-of-gammaradiation-on-hydrocortisone-in-solutions-and-topical-preparations(a181f1a9-e30a-43f1-b9f8-8127b0a68f2b).html ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.377371
Chicago Manual of Style (16th Edition):
Bosela, Ahmed Abdalla. “The effect of gamma-radiation on hydrocortisone in solutions and topical preparations.” 1987. Doctoral Dissertation, University of Bath. Accessed January 19, 2021.
https://researchportal.bath.ac.uk/en/studentthesis/the-effect-of-gammaradiation-on-hydrocortisone-in-solutions-and-topical-preparations(a181f1a9-e30a-43f1-b9f8-8127b0a68f2b).html ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.377371.
MLA Handbook (7th Edition):
Bosela, Ahmed Abdalla. “The effect of gamma-radiation on hydrocortisone in solutions and topical preparations.” 1987. Web. 19 Jan 2021.
Vancouver:
Bosela AA. The effect of gamma-radiation on hydrocortisone in solutions and topical preparations. [Internet] [Doctoral dissertation]. University of Bath; 1987. [cited 2021 Jan 19].
Available from: https://researchportal.bath.ac.uk/en/studentthesis/the-effect-of-gammaradiation-on-hydrocortisone-in-solutions-and-topical-preparations(a181f1a9-e30a-43f1-b9f8-8127b0a68f2b).html ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.377371.
Council of Science Editors:
Bosela AA. The effect of gamma-radiation on hydrocortisone in solutions and topical preparations. [Doctoral Dissertation]. University of Bath; 1987. Available from: https://researchportal.bath.ac.uk/en/studentthesis/the-effect-of-gammaradiation-on-hydrocortisone-in-solutions-and-topical-preparations(a181f1a9-e30a-43f1-b9f8-8127b0a68f2b).html ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.377371
Kansas State University
11.
Kumar, M. S. Amarendhra.
Studies on normal and experimentally altered circadian cortisol rhythms in ponies and cortisol levels in normal and adrenopathic dogs.
Degree: 1976, Kansas State University
URL: http://hdl.handle.net/2097/11387
Subjects/Keywords: Circadian rhythms; Hydrocortisone
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Kumar, M. S. A. (1976). Studies on normal and experimentally altered circadian cortisol rhythms in ponies and cortisol levels in normal and adrenopathic dogs. (Thesis). Kansas State University. Retrieved from http://hdl.handle.net/2097/11387
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Kumar, M S Amarendhra. “Studies on normal and experimentally altered circadian cortisol rhythms in ponies and cortisol levels in normal and adrenopathic dogs.” 1976. Thesis, Kansas State University. Accessed January 19, 2021.
http://hdl.handle.net/2097/11387.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Kumar, M S Amarendhra. “Studies on normal and experimentally altered circadian cortisol rhythms in ponies and cortisol levels in normal and adrenopathic dogs.” 1976. Web. 19 Jan 2021.
Vancouver:
Kumar MSA. Studies on normal and experimentally altered circadian cortisol rhythms in ponies and cortisol levels in normal and adrenopathic dogs. [Internet] [Thesis]. Kansas State University; 1976. [cited 2021 Jan 19].
Available from: http://hdl.handle.net/2097/11387.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Kumar MSA. Studies on normal and experimentally altered circadian cortisol rhythms in ponies and cortisol levels in normal and adrenopathic dogs. [Thesis]. Kansas State University; 1976. Available from: http://hdl.handle.net/2097/11387
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Kent State University
12.
Garcia , Monica.
Differential Effects of Hydrocortisone on PTSD Symptom
Clusters.
Degree: MA, College of Arts and Sciences / Department of
Psychological Sciences, 2018, Kent State University
URL: http://rave.ohiolink.edu/etdc/view?acc_num=kent1523196739368854
► Objective. A number of pharmacological agents have been examined for their possible efficacy at preventing/reducing the development of posttraumatic stress disorder (PTSD). These secondary interventions…
(more)
▼ Objective. A number of pharmacological agents have
been examined for their possible efficacy at preventing/reducing
the development of posttraumatic stress disorder (PTSD). These
secondary interventions (administered soon after trauma) have
produced mixed results, with the most promising findings being
linked to early administration of
hydrocortisone. However, effects
have been modest, and some previous research indicates that
hydrocortisone may be more efficacious in individuals without an
extensive mental health history. Due to the extreme heterogeneity
of PTSD, it is possible that
hydrocortisone differentially impacts
different PTSD symptoms. To determine if this is true, we examined
whether
hydrocortisone differentially impacted the different PTSD
symptom clusters. As cortisol has been found to impact memory
retrieval, we hypothesized that
hydrocortisone would have the
greatest impact on re-experiencing symptoms. Methods. Participants
(n=33) were recruited from a level 1-trauma center and were
randomized into either the placebo or
hydrocortisone group.
Participants completed the Peritraumatic Distress Inventory and the
Peritraumatic Dissociative Experiences Questionnaire at baseline,
and the Davidson Trauma Scale to assess PTSD symptoms at 1- and
3-months. Results. Using path analyses,
hydrocortisone recipients
reported significantly fewer re-experiencing symptoms at 1- and
3-months than placebo recipients. With respect to avoidance
symptoms, medication groups did not differ at 1-month, but the
hydrocortisone group reported significantly lower symptoms at
3-months. The
hydrocortisone group also reported fewer hyperarousal
symptoms at 1- and 3-months. Conclusions. Despite a number of
limitations, results supported our hypothesis in that
hydrocortisone was efficacious at preventing the development of
re-experiencing symptoms. However,
hydrocortisone also demonstrated
efficacy with respect to hyperarousal (at 1- and 3-months) and
avoidance (at 3-months). This suggests that early
hydrocortisone
treatment not only impacted memory retrieval, but also
physiological arousal and later avoidance/numbing symptoms. These
results suggest that
hydrocortisone may broadly impact the
development of PTSD symptoms. Though promising, these results are
considered preliminary, and should be interpreted with
caution.
Advisors/Committee Members: Delahanty , Douglas (Advisor).
Subjects/Keywords: Psychology; Psychobiology; Secondary Pharmacological Intervention, PTSD,
Hydrocortisone
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Garcia , M. (2018). Differential Effects of Hydrocortisone on PTSD Symptom
Clusters. (Masters Thesis). Kent State University. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=kent1523196739368854
Chicago Manual of Style (16th Edition):
Garcia , Monica. “Differential Effects of Hydrocortisone on PTSD Symptom
Clusters.” 2018. Masters Thesis, Kent State University. Accessed January 19, 2021.
http://rave.ohiolink.edu/etdc/view?acc_num=kent1523196739368854.
MLA Handbook (7th Edition):
Garcia , Monica. “Differential Effects of Hydrocortisone on PTSD Symptom
Clusters.” 2018. Web. 19 Jan 2021.
Vancouver:
Garcia M. Differential Effects of Hydrocortisone on PTSD Symptom
Clusters. [Internet] [Masters thesis]. Kent State University; 2018. [cited 2021 Jan 19].
Available from: http://rave.ohiolink.edu/etdc/view?acc_num=kent1523196739368854.
Council of Science Editors:
Garcia M. Differential Effects of Hydrocortisone on PTSD Symptom
Clusters. [Masters Thesis]. Kent State University; 2018. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=kent1523196739368854
13.
Pryor, Nan Webb.
Metabolism of Hydrocortisone by X-Irradiated Rat Liver Tissue as Determined by the Porter-Silber Chromagen Method.
Degree: 1959, North Texas State College
URL: https://digital.library.unt.edu/ark:/67531/metadc108062/
► The present study may be considered endocrinological and radiobiological in nature. The endocrinology phase was concerned with studying the changes in endocrine function following the…
(more)
▼ The present study may be considered endocrinological and radiobiological in nature. The endocrinology phase was concerned with studying the changes in endocrine function following the application of a stress agent. X-irradiation was chosen as the stressor in order to determine any difference in effect of this stressor from others which have been studied, e. g. heat, cold, metabolic poisons. Liver slices taken from rats at various time intervals following whole body X-irradiation were tested for their ability to metabolize
hydrocortisone from a Krebs-Ringer solution.
Advisors/Committee Members: Lott, James R., Guthrie, Rufus K..
Subjects/Keywords: hydrocortisone; metabolism; Porter-Silber; chromagen; Hydrocortisone – Metabolism.
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
University of Utah
14.
Stevenett, Kathryn.
Description of suspected adrenal insufficiency in the premature infant;.
Degree: MS, Nursing;, 1991, University of Utah
URL: http://content.lib.utah.edu/cdm/singleitem/collection/etd1/id/625/rec/284
► The purpose of this study is to describe the signs and symptoms of suspected adrenal insufficiency in the extremely premature infant. Fifteen extremely premature infants…
(more)
▼ The purpose of this study is to describe the signs and symptoms of suspected adrenal insufficiency in the extremely premature infant. Fifteen extremely premature infants (EPI) tested with adrenocorticotropic hormone (ACTH) and treated with hydrocortisone (HCTC) were reviewed to describe physiological differences prior to and post treatment with HCTC. Demographic variables were similar among infants. Baseline serum cortisol levels were less than reported normative values in 7 of 15 infants and response to ACTH was noted as adequate in 5 out of 15 infants. Statistically significant differences in pre and post serum potassium levels could not be supported due to outlying variables. A total of 7 infants had oliguria at the time of diagnosis; 3 resolved post ACTH testing and 4 resolved post HCTC. The latter 4 infants had a significant increase in urine output only after HCTC and despite previous hours of dopamine treatment. Systolic blood pressures (SBP's) rose significantly post HCTC. Mean Air-way pressure (MAP) and percent of inspired oxygen (Fio2) showed a significant improvement in all 15 infants, including 3 who were extubated and on nasal canula by 8 days post HCTC. The findings of this retrospective study are purely descriptive and in no way meant to promote the use of steroids among extremely premature infants. The description of findings may, however, promote future research as to the potential of adrenal insufficiency in this population.
Subjects/Keywords: Innervaton; Adrenocorticotropic Hormone; Hydrocortisone
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Stevenett, K. (1991). Description of suspected adrenal insufficiency in the premature infant;. (Masters Thesis). University of Utah. Retrieved from http://content.lib.utah.edu/cdm/singleitem/collection/etd1/id/625/rec/284
Chicago Manual of Style (16th Edition):
Stevenett, Kathryn. “Description of suspected adrenal insufficiency in the premature infant;.” 1991. Masters Thesis, University of Utah. Accessed January 19, 2021.
http://content.lib.utah.edu/cdm/singleitem/collection/etd1/id/625/rec/284.
MLA Handbook (7th Edition):
Stevenett, Kathryn. “Description of suspected adrenal insufficiency in the premature infant;.” 1991. Web. 19 Jan 2021.
Vancouver:
Stevenett K. Description of suspected adrenal insufficiency in the premature infant;. [Internet] [Masters thesis]. University of Utah; 1991. [cited 2021 Jan 19].
Available from: http://content.lib.utah.edu/cdm/singleitem/collection/etd1/id/625/rec/284.
Council of Science Editors:
Stevenett K. Description of suspected adrenal insufficiency in the premature infant;. [Masters Thesis]. University of Utah; 1991. Available from: http://content.lib.utah.edu/cdm/singleitem/collection/etd1/id/625/rec/284
15.
Pereira, Wendry Maria Paixão.
O estresse e suas correlações com a concentração sérica do cortisol em mulheres na menopausa.
Degree: PhD, Saúde, Ciclos de Vida e Sociedade, 2015, University of São Paulo
URL: http://www.teses.usp.br/teses/disponiveis/6/6136/tde-06082015-114447/
;
► Introdução - A menopausa é um processo natural do envelhecimento feminino que se associa a uma sucessão de eventos com repercussões biológicas e psicossociais, dentre…
(more)
▼ Introdução - A menopausa é um processo natural do envelhecimento feminino que se associa a uma sucessão de eventos com repercussões biológicas e psicossociais, dentre eles o estresse; definido como um estado de tensão que ocasiona a desordem na homeostase do organismo repercutindo na qualidade de vida da mulher. Objetivo - Investigar a presença do estresse em mulheres na menopausa e correlacionar com a concentração de cortisol, bem como associar o estresse com os sintomas musculoesqueléticos. Métodos - Estudo analítico transversal que investigou o estresse por meio do Inventário de Sintomas de Stress (ISSL) em 1200 mulheres da plataforma PROSAPIN cadastradas na Saúde da Família de Pindamonhangaba-SP. O método consistiu na aplicação de um questionário auto-referido. Os fatores associados foram investigados por meio de informações sócio-demográficas, hábitos de vida, história ginecológica e obstétrica, morbidades, dados antropométricos, laboratoriais e uso de medicamentos. Foram feitas análises bivariadas e multivariadas, utilizando um intervalo de confiança de 95 por cento . Testes de correlação - kappa e testes diagnósticos foram realizados comparando o estresse avaliado por questionário com a concentração do cortisol, no programa Stata. Resultados - O ISSL detectou estresse em 60,9 por cento das mulheres (IC95 por cento : 57,7 por cento a 64,1 por cento ) e o cortisol indicou a presença do estresse em 10,4 por cento (IC95 por cento : 8,1 por cento a 12,7 por cento ), não houve concordância entre a percepção do estresse e a mensuração do cortisol (k= 0,029). Os fatores associados à percepção do estresse foram: incontinência urinária, presença dos sintomas climatérios e de dor, qualidade do sono, depressão, acidente vascular encefálico e não ser cuidador de parente e possuir renda familiar. Os fatores associados ao cortisol foram: ansiedade, a falta de vitamina D, praticar atividade física e morar com ate três pessoas. Houve associação entre o estresse e os sintomas musculoesqueléticos, sobretudo com as regiões corporais do ombro, coluna lombar e joelho. Conclusão - A prevalência da percepção do estresse foi alta abrangendo mais da metade das mulheres, não houve correlação entre as medidas. Houve forte associação principalmente com a incontinência urinária, sintomas climatérios e musculoesqueléticos, ansiedade e falta de vitamina D. Sendo assim, considera-se que a presença do estresse intervém negativamente na qualidade de vida das mulheres na menopausa.
Introduction - Menopause is a natural female ageing.This process has been asssociated with a series of events like biological and psychosocial effects. Ageing process is associated with a series of events with biological and psychosocial effects, including stress defined as a state of tension causes of disorder in homeostasis reflecting on the quality of life women. Objective- Investigating the presence of stresses during its climacteric women the correlation with the concentration of cortisol and stress. It was associated with musculoskeletal symptoms. Methods…
Advisors/Committee Members: Aldrighi, José Mendes.
Subjects/Keywords: Climacteric; Climatério; Estresse; Hidrocortisona; Hydrocortisone; Menopausa; Menopause; Mulher; Stress; Women
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Pereira, W. M. P. (2015). O estresse e suas correlações com a concentração sérica do cortisol em mulheres na menopausa. (Doctoral Dissertation). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/6/6136/tde-06082015-114447/ ;
Chicago Manual of Style (16th Edition):
Pereira, Wendry Maria Paixão. “O estresse e suas correlações com a concentração sérica do cortisol em mulheres na menopausa.” 2015. Doctoral Dissertation, University of São Paulo. Accessed January 19, 2021.
http://www.teses.usp.br/teses/disponiveis/6/6136/tde-06082015-114447/ ;.
MLA Handbook (7th Edition):
Pereira, Wendry Maria Paixão. “O estresse e suas correlações com a concentração sérica do cortisol em mulheres na menopausa.” 2015. Web. 19 Jan 2021.
Vancouver:
Pereira WMP. O estresse e suas correlações com a concentração sérica do cortisol em mulheres na menopausa. [Internet] [Doctoral dissertation]. University of São Paulo; 2015. [cited 2021 Jan 19].
Available from: http://www.teses.usp.br/teses/disponiveis/6/6136/tde-06082015-114447/ ;.
Council of Science Editors:
Pereira WMP. O estresse e suas correlações com a concentração sérica do cortisol em mulheres na menopausa. [Doctoral Dissertation]. University of São Paulo; 2015. Available from: http://www.teses.usp.br/teses/disponiveis/6/6136/tde-06082015-114447/ ;
16.
Mattos, Maria Izabel da Silva.
Efeitos sistêmicos de antiinflamatórios esteroidais tópicos: modulação da inflamação aguda e avaliação de parâmetros hematológicos, imunológicos e endócrinos.
Degree: Mestrado, Patologia Experimental e Comparada, 2010, University of São Paulo
URL: http://www.teses.usp.br/teses/disponiveis/10/10133/tde-10082010-130548/
;
► Os glicocorticóides são muito utilizados na clínica veterinária por serem potentes inibidores da resposta inflamatória. São encontrados em muitas preparações tópicas, sozinhos ou combinados com…
(more)
▼ Os glicocorticóides são muito utilizados na clínica veterinária por serem potentes inibidores da resposta inflamatória. São encontrados em muitas preparações tópicas, sozinhos ou combinados com outros medicamentos e estão presentes, principalmente, em produtos destinados ao uso otológico. Mesmo quando aplicados topicamente, sabe-se que existe certo grau de absorção. Com a disponibilidade de novos glicocorticóides sintéticos mais potentes, vem sendo sugerido recentemente, a ocorrência de hiperadrenocorticismo iatrogênico em pequenos animais. Com a finalidade de se testar a hipótese que a utilização de preparações otológicas contendo glicocorticóides podem ocorrer em efeitos sistêmicos, o presente estudo avaliou três antiinflamatórios esteroidais comumente utilizados no tratamento de otite em cães e gatos, quais sejam a hidrocortisona, a betametasona e a triancinolona. Para tanto, ratos foram tratados tópicamente, via auricular, a cada 12 horas, durante 7, 14 e 21 dias, com os fármacos descritos acima. Utilizamos o edema de pata induzido pela injeção de carragenina como forma de avaliar a existência de níveis efetivos de antiinflamatórios circulantes. Ainda, foram avaliados vários parâmetros tais como variação de peso corpóreo, peso relativo de baço e adrenais, hemograma completo, índice de proliferação de linfócitos e fagocitose e burst oxidativo realizados por neutrófilos circulantes. Além disso, foi avaliado o nível de corticosterona plasmática nos animais tratados com glicocorticóides tópicos. O tratamento tópico com antiinflamatórios esteroidais levou a redução no volume de edema inflamatório, mais evidente com a triancinolona. De forma geral, houve queda no ganho, ou mesmo perda de peso corpóreo durante o tratamento tópico com os antiinflamatórios esteroidais empregados. Em alguns casos, essa redução de peso corpóreo foi acompanhada de diminuição do peso relativo do baço e adrenais, particularmente com a betametasona. A principal alteração observada no hemograma foi leucopenia, mais evidente com a triancinolona. Houve redução dos níveis plasmáticos de corticosterona, mais duradoura com a betametasona. Os tratamentos tópicos causaram discreta redução na intensidade e percentual de fagocitose realizada por neutrófilos circulantes, bem como na produção de espécies reativas de oxigênio. O estudo aponta que glicocorticóides tópicos comumente empregados na terapêutica veterinária podem ser absorvidos, na dependência da molécula empregada e de seu tempo de utilização, causando alterações sistêmicas relevantes já após 7 dias de tratamento. Sugerimos uma maior cautela e acompanhamento veterinário dos pacientes nos casos que haja necessidade de emprego de tais medicamentos por períodos prolongados.
Glucocorticoids are commonly employed in veterinary practice because they are potent inhibitors of the inflammatory response. They are present in many topical formulations, alone or combined with other active compounds, particularly in otic ointments. Even when applied topically, certain degree of absortion is known to…
Advisors/Committee Members: Pinto, Frederico Azevedo da Costa.
Subjects/Keywords: Betametasona; Betamethasone; Efeitos sistêmicos; Hidrocortisona; Hydrocortisone; system effects; Triamcinolone; Triancinolona
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Mattos, M. I. d. S. (2010). Efeitos sistêmicos de antiinflamatórios esteroidais tópicos: modulação da inflamação aguda e avaliação de parâmetros hematológicos, imunológicos e endócrinos. (Masters Thesis). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/10/10133/tde-10082010-130548/ ;
Chicago Manual of Style (16th Edition):
Mattos, Maria Izabel da Silva. “Efeitos sistêmicos de antiinflamatórios esteroidais tópicos: modulação da inflamação aguda e avaliação de parâmetros hematológicos, imunológicos e endócrinos.” 2010. Masters Thesis, University of São Paulo. Accessed January 19, 2021.
http://www.teses.usp.br/teses/disponiveis/10/10133/tde-10082010-130548/ ;.
MLA Handbook (7th Edition):
Mattos, Maria Izabel da Silva. “Efeitos sistêmicos de antiinflamatórios esteroidais tópicos: modulação da inflamação aguda e avaliação de parâmetros hematológicos, imunológicos e endócrinos.” 2010. Web. 19 Jan 2021.
Vancouver:
Mattos MIdS. Efeitos sistêmicos de antiinflamatórios esteroidais tópicos: modulação da inflamação aguda e avaliação de parâmetros hematológicos, imunológicos e endócrinos. [Internet] [Masters thesis]. University of São Paulo; 2010. [cited 2021 Jan 19].
Available from: http://www.teses.usp.br/teses/disponiveis/10/10133/tde-10082010-130548/ ;.
Council of Science Editors:
Mattos MIdS. Efeitos sistêmicos de antiinflamatórios esteroidais tópicos: modulação da inflamação aguda e avaliação de parâmetros hematológicos, imunológicos e endócrinos. [Masters Thesis]. University of São Paulo; 2010. Available from: http://www.teses.usp.br/teses/disponiveis/10/10133/tde-10082010-130548/ ;
California State University – Northridge
17.
Hale, Robin A.
Hydrocortisone induced stimulation of teratoma cell adhesiveness.
Degree: MS, Biology, 1977, California State University – Northridge
URL: http://hdl.handle.net/10211.3/122657
► Specific levels of active glutamine synthetase (GS) may be involved in regulating intercellular adhesiveness in teratoma, as well as other cell types. To investigate this…
(more)
▼ Specific levels of active glutamine synthetase (GS) may be involved in regulating intercellular adhesiveness in teratoma, as well as other cell types. To investigate this question, two teratoma cell lines were incubated with hydrocortisone (HC), a hormone known to stimulate cellular GS specific activity levels. Under conditions of HC incubation, increased GS specific activity and intercellular adhesion were observed. The increased adhesiveness may be directly related to the increased GS specific activity through the synthesis of L-glutamine which is required for intercellular adhesion.
Subjects/Keywords: Hydrocortisone.; Dissertations, Academic – CSUN – Biology.
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Hale, R. A. (1977). Hydrocortisone induced stimulation of teratoma cell adhesiveness. (Masters Thesis). California State University – Northridge. Retrieved from http://hdl.handle.net/10211.3/122657
Chicago Manual of Style (16th Edition):
Hale, Robin A. “Hydrocortisone induced stimulation of teratoma cell adhesiveness.” 1977. Masters Thesis, California State University – Northridge. Accessed January 19, 2021.
http://hdl.handle.net/10211.3/122657.
MLA Handbook (7th Edition):
Hale, Robin A. “Hydrocortisone induced stimulation of teratoma cell adhesiveness.” 1977. Web. 19 Jan 2021.
Vancouver:
Hale RA. Hydrocortisone induced stimulation of teratoma cell adhesiveness. [Internet] [Masters thesis]. California State University – Northridge; 1977. [cited 2021 Jan 19].
Available from: http://hdl.handle.net/10211.3/122657.
Council of Science Editors:
Hale RA. Hydrocortisone induced stimulation of teratoma cell adhesiveness. [Masters Thesis]. California State University – Northridge; 1977. Available from: http://hdl.handle.net/10211.3/122657
California State University – Northridge
18.
Scordato, John Charles.
Hydrocortisone effects on adhesion and glutamine synthetase specific activity during the cell cycle of cultured mouse teratoma cells.
Degree: MS, Biology, 1979, California State University – Northridge
URL: http://hdl.handle.net/10211.3/125247
► Previous studies of teratoma cells in batch culture demonstrated that glutamine synthetase (GS) specific activity was cell density dependent, increasing as the culture approached confluency.…
(more)
▼ Previous studies of teratoma cells in batch culture
demonstrated that glutamine synthetase (GS) specific activity
was cell density dependent, increasing as the culture
approached confluency. Other studies also showed that intercellular adhesion and GS specific activity increased in the presence of hydrocortisone. Confluency frequently reflects a non-cyclic cell population. Hence, in batch culture
the increase in GS activity at confluency may be a
consequence of the cells either leaving the cell cycle or
coming into register at a given point in it, e.g. G1.
Therefore it is desirable to determine if GS activity and
adhesion are properties of non-cyclicing as well as actively growing populations. These studies were undertaken to determine if there is a relationship between intercellular
adhesion and GS specific activity during the cell cycle and
if hydrocortisone effects these parameters. To determine
if increased cell adhesiveness and GS specific activity occur
at specific times during the cell cycle, cell populations
were synchronized with thymidine (3m.M) plus colcemid
(5ug/ml). (See more in text.)
Subjects/Keywords: Hydrocortisone.; Dissertations, Academic – CSUN – Biology.
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Scordato, J. C. (1979). Hydrocortisone effects on adhesion and glutamine synthetase specific activity during the cell cycle of cultured mouse teratoma cells. (Masters Thesis). California State University – Northridge. Retrieved from http://hdl.handle.net/10211.3/125247
Chicago Manual of Style (16th Edition):
Scordato, John Charles. “Hydrocortisone effects on adhesion and glutamine synthetase specific activity during the cell cycle of cultured mouse teratoma cells.” 1979. Masters Thesis, California State University – Northridge. Accessed January 19, 2021.
http://hdl.handle.net/10211.3/125247.
MLA Handbook (7th Edition):
Scordato, John Charles. “Hydrocortisone effects on adhesion and glutamine synthetase specific activity during the cell cycle of cultured mouse teratoma cells.” 1979. Web. 19 Jan 2021.
Vancouver:
Scordato JC. Hydrocortisone effects on adhesion and glutamine synthetase specific activity during the cell cycle of cultured mouse teratoma cells. [Internet] [Masters thesis]. California State University – Northridge; 1979. [cited 2021 Jan 19].
Available from: http://hdl.handle.net/10211.3/125247.
Council of Science Editors:
Scordato JC. Hydrocortisone effects on adhesion and glutamine synthetase specific activity during the cell cycle of cultured mouse teratoma cells. [Masters Thesis]. California State University – Northridge; 1979. Available from: http://hdl.handle.net/10211.3/125247
Université Laval
19.
Pearson, Jessica.
Hypothèse de programmation foetale : implications pour la
sécrétion de cortisol et le développement de l'enfant.
Degree: 2015, Université Laval
URL: http://hdl.handle.net/20.500.11794/26282
► L’objectif principal de cette thèse est de vérifier l’influence des facteurs prénataux sur le développement de l’enfant et d’explorer les mécanismes par lesquels cette influence…
(more)
▼ L’objectif principal de cette thèse est de vérifier
l’influence des facteurs prénataux sur le développement de l’enfant
et d’explorer les mécanismes par lesquels cette influence survient.
Dans un premier temps, une méta-analyse a été effectuée afin de
vérifier l’association entre divers facteurs prénataux et la
sécrétion de cortisol des enfants âgés de moins de 5 ans. Les
variables prénatales considérées sont le stress maternel prénatal,
ainsi que la consommation prénatale d’alcool, de tabac ou de
drogues. Dix-neuf études ont été retenues et les résultats
démontrent un lien significatif entre les facteurs prénataux et la
sécrétion de cortisol chez l’enfant (d = .36, p < .001). Les
analyses de modération révèlent que cette association est plus
élevée en ce qui concerne la consommation prénatale d’alcool, la
sécrétion de cortisol basal et l’utilisation de devis de recherche
rétrospectifs. Les effets de modération obtenus suggèrent entre
autres que des mécanismes d’action différents pourraient être en
cause selon le type d’exposition prénatale étudié. Dans un deuxième
temps, une étude empirique a été réalisée afin d’explorer les
mécanismes qui pourraient expliquer l’association entre les
facteurs prénataux et le développement de l’enfant. Plusieurs
études suggèrent que la sécrétion de cortisol de l’enfant et la
sensibilité maternelle puissent agir comme médiateurs dans
l’association entre le stress maternel prénatal et le développement
cognitif de l’enfant. Cette étude empirique a donc pour objectif de
tester ces modèles de médiation et de vérifier la présence d’effets
directs du stress maternel prénatal, de la sécrétion de cortisol de
l’enfant et de la sensibilité maternelle sur le développement
cognitif de l’enfant. Les résultats obtenus documentent la présence
d’effets directs et indépendants du stress maternel prénatal, de la
sécrétion de cortisol de l’enfant et de la sensibilité maternelle
afin de prédire le développement cognitif de l’enfant à 3 mois. De
plus, aucune relation de médiation n’est documentée. Les résultats
soutiennent ainsi à la fois l’influence des facteurs de
l’environnement prénatal, celle de l’environnement postnatal et une
contribution des facteurs propres à la physiologie de l’enfant dans
la prédiction du développement cognitif en bas
âge.
The purpose of the present doctoral thesis is to
examine the association between prenatal environment and early
human development and to investigate mechanisms by which fetal
programming can occur. To clarify this association, we conducted
two different studies. First, we did a meta-analysis to examine the
relation between various prenatal variables and child cortisol
secretion. Prenatal variables considered were maternal prenatal
stress and maternal prenatal use of alcohol, tobacco and drugs.
Nineteen studies were included in the analysis and results reveal
and significant and moderate association between prenatal variables
and child cortisol secretion (d = .36, p < .001). Moderator
analyses reveal that greater effect sizes can be traced to…
Advisors/Committee Members: Tarabulsy, George M..
Subjects/Keywords: BF 20.5 UL 2015; Hydrocortisone; Enfants – Développement; Influence prénatale
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Pearson, J. (2015). Hypothèse de programmation foetale : implications pour la
sécrétion de cortisol et le développement de l'enfant. (Thesis). Université Laval. Retrieved from http://hdl.handle.net/20.500.11794/26282
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Pearson, Jessica. “Hypothèse de programmation foetale : implications pour la
sécrétion de cortisol et le développement de l'enfant.” 2015. Thesis, Université Laval. Accessed January 19, 2021.
http://hdl.handle.net/20.500.11794/26282.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Pearson, Jessica. “Hypothèse de programmation foetale : implications pour la
sécrétion de cortisol et le développement de l'enfant.” 2015. Web. 19 Jan 2021.
Vancouver:
Pearson J. Hypothèse de programmation foetale : implications pour la
sécrétion de cortisol et le développement de l'enfant. [Internet] [Thesis]. Université Laval; 2015. [cited 2021 Jan 19].
Available from: http://hdl.handle.net/20.500.11794/26282.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Pearson J. Hypothèse de programmation foetale : implications pour la
sécrétion de cortisol et le développement de l'enfant. [Thesis]. Université Laval; 2015. Available from: http://hdl.handle.net/20.500.11794/26282
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Otago
20.
Wells, Sarah.
Development of a transdermal patch using fabrics
.
Degree: 2013, University of Otago
URL: http://hdl.handle.net/10523/4082
► Atopic dermatitis is a major public health problem worldwide. It has a wide clinical spectrum ranging from minor forms such as dry, depigmented patches (pityraisis…
(more)
▼ Atopic dermatitis is a major public health problem worldwide. It has a wide clinical spectrum ranging from minor forms such as dry, depigmented patches (pityraisis alba), to major forms with erythrodermic rash, with the rash being slightly more common in boys (Beiber and Prolss, 2008). The age of onset is generally 2-6 months.
Several treatments are available for atopic dermatitis including: oral corticosteroids, topical corticosteroids, calcineurin inhibitors and antibiotics. Given orally, corticosteroids can have permanent and severe side effects (e.g. Cushing’s syndrome). Topical or transdermal drug delivery is preferred over oral treatments because it allows prolonged continuous and consistent release of the drug into the systemic circulation, direct drug release to the target area, and the ability to avoid first-pass gastrointestinal and hepatic metabolism to minimise adverse effects. At the time of this study, at least two textiles had been developed for the treatment of atopic dermatitis: DermaSilk® and Padycare®. Both these fabrics have antimicrobial finishes which treat the secondary bacterial infection generally present on the erythrodermic rash. Previous studies have shown that both fabrics are effective in treating the rash present in atopic dermatitis. However, at the time of the current study DermaSilk® was not commonly available in New Zealand and was expensive, therefore it was not a viable option for wide use. The other fabric available, Padycare®, was made from silver filaments. Silver had been shown to have potential side effects to humans and the environment. Thus, there was a need for an inexpensive, safe, readily available dermal treatment for atopic dermatitis.
The purpose of the current study was to design a cotton and silk transdermal patch for the treatment of atopic dermatitis and to study the relevant physical properties of these fabrics. The mass, thickness, air permeability, water vapour permeability and LAC of the fabrics were measured. The fabric specimens were then immersed in one of the two different concentrations (5mg/ml and 10mg/ml) of
hydrocortisone and ethanol solutions for two minutes. The specimens were then dried and physical properties re-measured. FTIR, XRPD and SEM were performed to determine whether the
hydrocortisone adhered to the fabric and if so in what solid state form (amphorous or crystalline). The physical properties of the fabrics differed from each other but both would be suitable for a transdermal patch in the treatment of atopic dermatitis. The physical properties of the fabrics did not differ after immersion compared to before. FTIR and XRPD did not show any difference between the non-treated, 5mg/ml and 10mg/ml specimens. Neither FTIR nor XRPD showed any difference between the non-treated and the pipetted samples; therefore both instruments may not have been able to detect small amounts of
hydrocortisone on the fabrics. SEM confirmed that there was no visible evidence of
hydrocortisone on specimens immersed in either of the two concentrations tested,…
Advisors/Committee Members: Laing, Raechel (advisor).
Subjects/Keywords: Atopic dermatitis;
Hydrocortisone;
Cotton;
Silk;
Topical/transdermal drug delivery
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Wells, S. (2013). Development of a transdermal patch using fabrics
. (Masters Thesis). University of Otago. Retrieved from http://hdl.handle.net/10523/4082
Chicago Manual of Style (16th Edition):
Wells, Sarah. “Development of a transdermal patch using fabrics
.” 2013. Masters Thesis, University of Otago. Accessed January 19, 2021.
http://hdl.handle.net/10523/4082.
MLA Handbook (7th Edition):
Wells, Sarah. “Development of a transdermal patch using fabrics
.” 2013. Web. 19 Jan 2021.
Vancouver:
Wells S. Development of a transdermal patch using fabrics
. [Internet] [Masters thesis]. University of Otago; 2013. [cited 2021 Jan 19].
Available from: http://hdl.handle.net/10523/4082.
Council of Science Editors:
Wells S. Development of a transdermal patch using fabrics
. [Masters Thesis]. University of Otago; 2013. Available from: http://hdl.handle.net/10523/4082
Columbia University
21.
Renna, Megan Elizabeth.
Perseveration and health: An experimental examination of worry and relaxation on autonomic, endocrine, and immunological processes.
Degree: 2019, Columbia University
URL: https://doi.org/10.7916/d8-4z8g-c520
► The field of psychoneuroimmunology seeks to examine the impact of stress and other psychological processes on physical health. While some theories suggest that processes such…
(more)
▼ The field of psychoneuroimmunology seeks to examine the impact of stress and other psychological processes on physical health. While some theories suggest that processes such as worry may have a significant impact on prolonging the physiological stress response and subsequently increasing risk for long-term health issues, to date, this research has not yet thoroughly examined the impact of worry on physical health processes. The current study sought to combine theories from clinical and health psychology to investigate the impact of experimentally-induced worry and relaxation on cortisol, heart rate variability (HRV), and inflammation. Participants (N = 85) were community members from the New York City area. They completed worry and relaxation inductions within the laboratory while HRV was collected continuously. Three blood samples were taken throughout the study to test for inflammation and cortisol. Results indicated changes in HRV, IL-6, and IFN-γ throughout the study conditions that were not moderated by levels of trait worry. HRV, cortisol, and inflammation did not covary throughout the different experimental conditions and changes in cortisol and/or HRV did not temporally precede changes in inflammation throughout the study. Overall, the findings from the current study offer insight into the contrasting impact that worry and relaxation have on physiological biomarkers and highlights important directions for future research in the field of psychoneuroimmunology.
Subjects/Keywords: Clinical psychology; Worry; Emotions – Physiological aspects; Psychoneuroimmunology; Hydrocortisone
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Renna, M. E. (2019). Perseveration and health: An experimental examination of worry and relaxation on autonomic, endocrine, and immunological processes. (Doctoral Dissertation). Columbia University. Retrieved from https://doi.org/10.7916/d8-4z8g-c520
Chicago Manual of Style (16th Edition):
Renna, Megan Elizabeth. “Perseveration and health: An experimental examination of worry and relaxation on autonomic, endocrine, and immunological processes.” 2019. Doctoral Dissertation, Columbia University. Accessed January 19, 2021.
https://doi.org/10.7916/d8-4z8g-c520.
MLA Handbook (7th Edition):
Renna, Megan Elizabeth. “Perseveration and health: An experimental examination of worry and relaxation on autonomic, endocrine, and immunological processes.” 2019. Web. 19 Jan 2021.
Vancouver:
Renna ME. Perseveration and health: An experimental examination of worry and relaxation on autonomic, endocrine, and immunological processes. [Internet] [Doctoral dissertation]. Columbia University; 2019. [cited 2021 Jan 19].
Available from: https://doi.org/10.7916/d8-4z8g-c520.
Council of Science Editors:
Renna ME. Perseveration and health: An experimental examination of worry and relaxation on autonomic, endocrine, and immunological processes. [Doctoral Dissertation]. Columbia University; 2019. Available from: https://doi.org/10.7916/d8-4z8g-c520
Massey University
22.
Evans, Pandora Carlyon.
The effect of ethanol on cortisol metabolism in man.
Degree: MS, Biochemistry, 1979, Massey University
URL: http://hdl.handle.net/10179/12403
► Methods were developed for the estimation of human plasma cortisol by radioimmunoassay and urinary 6β-hydroxycortisol (6βOHF) by colorimetry after separation by thin layer chromatography (TLC).…
(more)
▼ Methods were developed for the estimation of human plasma cortisol by radioimmunoassay and urinary 6β-hydroxycortisol (6βOHF) by colorimetry after separation by thin layer chromatography (TLC). In addition profiles of urinary neutral steroids were obtained by gas chromatographic separation of methoxime-trimethylsilyl derivatives from urine extracts on a glass capillary column. This approach was found to be more sensitive and reproducible than profile studies based on TLC separation and colorimetric estimation. Pilot studies of the plasma cortisol levels of normal subjects showed a consistent rise in cortisol during alcohol loading under the conditions of the observations, but in hospital patients admitted with acute alcohol intoxication, variability in the experimental conditions masked any consistent changes. Large variations in method reproducibility as well as subject differences affected results from the measurement of 6βOHF and chloroform extractable 17-hydroxycorticosteroids in one normal and four alcoholic subjects, rendering apparent initial differences insignificant. The results suggest, but do not demonstrate, that alcohol ingestion may divert normal cortisol metabolism into a pathway leading to the production of 6βOHF. Urinary steroid profiles obtained from two normal subjects, one normal subject under conditions of alcohol load and one alcoholic subject suggest that any effects of alcohol on cortisol metabolism are subtle and would require study of a large number of cases to define them. This work has served to delineate the faults and potential of various approaches to the study of cortisol metabolism and the possible effects of alcohol thereon. It would seem that their application in carefully designed and well controlled experiments to a larger number of subjects is necessary to obtain the information desired.
Subjects/Keywords: Hydrocortisone;
Alcohol body;
Metabolism
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Evans, P. C. (1979). The effect of ethanol on cortisol metabolism in man. (Masters Thesis). Massey University. Retrieved from http://hdl.handle.net/10179/12403
Chicago Manual of Style (16th Edition):
Evans, Pandora Carlyon. “The effect of ethanol on cortisol metabolism in man.” 1979. Masters Thesis, Massey University. Accessed January 19, 2021.
http://hdl.handle.net/10179/12403.
MLA Handbook (7th Edition):
Evans, Pandora Carlyon. “The effect of ethanol on cortisol metabolism in man.” 1979. Web. 19 Jan 2021.
Vancouver:
Evans PC. The effect of ethanol on cortisol metabolism in man. [Internet] [Masters thesis]. Massey University; 1979. [cited 2021 Jan 19].
Available from: http://hdl.handle.net/10179/12403.
Council of Science Editors:
Evans PC. The effect of ethanol on cortisol metabolism in man. [Masters Thesis]. Massey University; 1979. Available from: http://hdl.handle.net/10179/12403
Virginia Tech
23.
Bruns, Nicholas Joseph.
Vitamin A deficiency: Serum cortisol and immunoglobulin G levels in lambs.
Degree: MS, Animal Science, 1986, Virginia Tech
URL: http://hdl.handle.net/10919/45753
► Serum cortisol and immunoglobulin G (IgG) concentrations were measured to investigate the relationship between vitamin A status and immune function in lambs. Twenty-four crossbred ewe…
(more)
▼ Serum cortisol and immunoglobulin G (IgG) concentrations were measured to investigate the relationship between vitamin A status and immune function in lambs. Twenty-four crossbred ewe lambs were each fed 900 g·d-1 of a carotene—deficient diet composed of 95.5% whole oats, 3% molasses, .5% trace mineral salt and 1% limestone. All lambs were injected monthly with vitamins D and E and with selenium. The 12 control lambs also received a 100,000 IU oral dose of vitamin A palmitate in capsule form every 2 wk. All lambs were challenged by injecting them with 1 mg ovalbumin in 1 ml of Freund’s complete adjuvant. At the time of challenge, serum vitamin A levels for the control and A-deficient (A—def) lambs were 33.3 and 3.1 ug·dl-1 respectively. Blood was collected prior to and 6, 13, 20 and 34 d post—challenge. The lambs were then reschallenged using the same antigen and blood was obtained 1, 2, 6 and 22 d post—challenge. Lambs were sacrificed at the end of the second challenge period. Spleen weights were obtained and gross post—mortem observations were made at this time.
Advisors/Committee Members: Webb, K. E., Jr. (committeechair), McCarthy, F. D. (committee member), Kornegay, E. T. (committee member), Elgert, K. D. (committee member).
Subjects/Keywords: Hydrocortisone; LD5655.V855 1986.B786
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Bruns, N. J. (1986). Vitamin A deficiency: Serum cortisol and immunoglobulin G levels in lambs. (Masters Thesis). Virginia Tech. Retrieved from http://hdl.handle.net/10919/45753
Chicago Manual of Style (16th Edition):
Bruns, Nicholas Joseph. “Vitamin A deficiency: Serum cortisol and immunoglobulin G levels in lambs.” 1986. Masters Thesis, Virginia Tech. Accessed January 19, 2021.
http://hdl.handle.net/10919/45753.
MLA Handbook (7th Edition):
Bruns, Nicholas Joseph. “Vitamin A deficiency: Serum cortisol and immunoglobulin G levels in lambs.” 1986. Web. 19 Jan 2021.
Vancouver:
Bruns NJ. Vitamin A deficiency: Serum cortisol and immunoglobulin G levels in lambs. [Internet] [Masters thesis]. Virginia Tech; 1986. [cited 2021 Jan 19].
Available from: http://hdl.handle.net/10919/45753.
Council of Science Editors:
Bruns NJ. Vitamin A deficiency: Serum cortisol and immunoglobulin G levels in lambs. [Masters Thesis]. Virginia Tech; 1986. Available from: http://hdl.handle.net/10919/45753
Tampere University
24.
Laaninen, Matias.
Prediction and management of complications after pancreaticoduodenectomy
.
Degree: 2016, Tampere University
URL: https://trepo.tuni.fi/handle/10024/98769
► Haiman pään poistoleikkauksen komplikaatioita voidaan vähentää hydrokortisonihoidolla Haiman pään ja pohjukaissuolen poistava leikkaus tehdään yleensä haiman pään seudun kasvaimen vuoksi. Vuosien mittaan tämän vaativan leikkauksen…
(more)
▼ Haiman pään poistoleikkauksen komplikaatioita voidaan vähentää hydrokortisonihoidolla
Haiman pään ja pohjukaissuolen poistava leikkaus tehdään yleensä haiman pään seudun kasvaimen vuoksi. Vuosien mittaan tämän vaativan leikkauksen kuolleisuus on laskenut 1–5 prosenttiin, mutta yhä melkein puolet potilaista kärsii merkittävästä komplikaatiosta. Komplikaatiot viivästyttävät toipumista, pitkittävät sairaalahoitoa, voivat johtaa erilaisiin toimenpiteisiin, uusintaleikkauksiin ja pahimmillaan johtavat potilaan menehtymiseen. Ne voivat myös viivästyttää leikkauksenjälkeisen liitännäissyöpälääkehoidon aloitusta. Leikkauksenjälkeinen haimatulehdus voi aiempien tutkimusten perusteella olla mahdollinen altistava tekijä haiman pään poistoleikkauksen komplikaatioille. Eläinkokeet ovat osoittaneet, että haiman omat asinus- ja stellaattisolut voivat toimia tulehdussolun tavoin. Käsitys haiman tulehduksesta on muuttunut viime vuosien aikana. Väitöstutkimuksen tavoitteena oli selvittää haiman leikkauksenjälkeisen tulehduksen mahdollista yhteyttä komplikaatioihin.
Haiman solujen jakauma vaihtelee haiman kunnosta riippuen, ja terveessä haimassa on yleensä runsaasti asinussoluja. Ensimmäinen osatyö osoitti, että asinussolujen suuri määrä haiman katkaisupinnassa altistaa haiman leikkauksenjälkeiselle tulehdukselle sekä komplikaatioille. Riskipotilaan rajaksi tunnistettiin yli 40 % asinuspinta-ala. Löydös vahvistui neljännessä osatyössä: Alle 40 % asinuspinta-alan potilaat välttyivät vaikeilta komplikaatioilta.
Toinen osatyö keskittyi riskihaiman (yli 40 % asinuspinta-ala) ja ei-riskihaiman (fibroottinen haima) leikkaustenjälkeisten tulehdusreaktioiden eroihin. Riskihaimassa leikkauksenjälkeinen tulehdusreaktio (Nf-κB ja MCP-1 tulehdusvälittäjä-aineiden aktivaatio) voimistui huomattavasti ensimmäisen 4 tunnin aikana haiman katkaisun jälkeen, kun taas fibroottisessa haimassa tulehdusreaktio pysyi ennallaan. Löydös tukee ajatusta, että leikkauksenjälkeinen tulehdusprosessi alkaa välittömästi kirurgisen vaurion jälkeen asinussolurikkaassa haimassa.
Kolmannessa osatyössä luotiin asinus- ja stellaattisolujen yhdistelmäviljelmä niiden vuorovaikutusten tutkimista varten. Viljelmässä todettiin, että sekä asinus- että stellaattisolut stimuloivat toisiaan: asinussolut aktivoivat stellaattisoluja (jotka edelleen muodostavat fibroosia), ja toisaalta stellaattisolut aktivoivat asinussoluja. Mekanismi toimii noidankehän tavoin haiman akuutissa tulehduksessa.
Neljäs osatyö oli satunnaistettu, lumelääkekontrolloitu tutkimus, jossa pyrittiin vähentämään leikkauksenjälkeistä tulehdusreaktiota ja komplikaatioita riskipotilailla tulehdusta vaimentavalla hydrokortisonihoidolla. Korkean riskin potilaat (yli 40 % asinuspinta-ala) määritettiin leikkauksen aikana. Juuri ennen leikkausta aloitettua lääkehoitoa jatkettiin kahden leikkauksenjälkeisen päivän ajan. Hydrokortisonia saaneet potilaat saivat huomattavasti vähemmän vakavia komplikaatiota kuin lumelääkettä saaneet, 18 vs. 41 %. Tämän tutkimuksen perusteella neljän riskipotilaan hoitaminen…
Subjects/Keywords: Haiman pään poistoleikkaus
;
asinus
;
hydrokortisoni
;
Whipple
;
pancreaticoduodenectomy
;
acinar
;
acini
;
hydrocortisone
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Laaninen, M. (2016). Prediction and management of complications after pancreaticoduodenectomy
. (Doctoral Dissertation). Tampere University. Retrieved from https://trepo.tuni.fi/handle/10024/98769
Chicago Manual of Style (16th Edition):
Laaninen, Matias. “Prediction and management of complications after pancreaticoduodenectomy
.” 2016. Doctoral Dissertation, Tampere University. Accessed January 19, 2021.
https://trepo.tuni.fi/handle/10024/98769.
MLA Handbook (7th Edition):
Laaninen, Matias. “Prediction and management of complications after pancreaticoduodenectomy
.” 2016. Web. 19 Jan 2021.
Vancouver:
Laaninen M. Prediction and management of complications after pancreaticoduodenectomy
. [Internet] [Doctoral dissertation]. Tampere University; 2016. [cited 2021 Jan 19].
Available from: https://trepo.tuni.fi/handle/10024/98769.
Council of Science Editors:
Laaninen M. Prediction and management of complications after pancreaticoduodenectomy
. [Doctoral Dissertation]. Tampere University; 2016. Available from: https://trepo.tuni.fi/handle/10024/98769
University of Texas – Austin
25.
Beckner, Victoria Lemle, 1966-.
The effects of stress on different stages of memory.
Degree: PhD, Psychology, 2004, University of Texas – Austin
URL: http://hdl.handle.net/2152/1188
► Research suggests that memory is influenced by stress and the associated rise of glucocorticoids, such as cortisol. While human studies have generally found a negative…
(more)
▼ Research suggests that memory is influenced by stress and the associated rise of glucocorticoids, such as cortisol. While human studies have generally found a negative effect of stress and elevated cortisol on memory, animal studies have demonstrated a dose-dependent facilitative effect. These discrepant findings may be a result of methodological limitations in the human literature, which often confound the different stages of memory by elevating cortisol levels prior to encoding, consolidation and retrieval. The purpose of the current study was to parse the effects of an acute psychosocial stressor on these separate memory processes by varying the timing of the stressor. Based on recent evidence, we predicted that stress would enhance encoding and consolidation, but impair retrieval. 208 college students (63 male, 138 female, mean age = 18.9) were randomly assigned to a no-stress control group (n = 51) or one of three groups stressed at different time points: prior to stimulus presentation (encoding/ consolidation, n = 51), immediately after stimuli presentation (consolidation, n = 56), or just before memory testing 48 hours later (retrieval, n = 50). Salivary cortisol was measured at baseline and 20 minutes after the stressor. Both verbal and visual memory was measured at the 48-hr delay using a film stimulus developed by the investigator and
with the WMS-III narrative. Results demonstrated that the group stressed prior to consolidation significantly outperformed controls on the film recognition at delay for verbal and total scores. This effect may have been related to cortisol response, as this was the only stress group to exhibit a significant increase in cortisol (40%) following the stressor. No significant differences in memory were found between the other stress conditions and controls. Within-group correlations between change in cortisol and memory were not significant, but exploratory analyses revealed a small but significant positive correlation for cortisol and verbal scores on the film recognition test across all groups (rxy = .18). Results support the hypothesis that stress enhances consolidation of new information, and provides the first evidence of this for verbal memory. Findings did not support a detrimental effect of stress on retrieval.
Advisors/Committee Members: Tucker, David M., 1953- (advisor), Markman, Arthur B. (advisor).
Subjects/Keywords: Stress (Physiology); Memory – Testing; Hydrocortisone
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Beckner, Victoria Lemle, 1. (2004). The effects of stress on different stages of memory. (Doctoral Dissertation). University of Texas – Austin. Retrieved from http://hdl.handle.net/2152/1188
Chicago Manual of Style (16th Edition):
Beckner, Victoria Lemle, 1966-. “The effects of stress on different stages of memory.” 2004. Doctoral Dissertation, University of Texas – Austin. Accessed January 19, 2021.
http://hdl.handle.net/2152/1188.
MLA Handbook (7th Edition):
Beckner, Victoria Lemle, 1966-. “The effects of stress on different stages of memory.” 2004. Web. 19 Jan 2021.
Vancouver:
Beckner, Victoria Lemle 1. The effects of stress on different stages of memory. [Internet] [Doctoral dissertation]. University of Texas – Austin; 2004. [cited 2021 Jan 19].
Available from: http://hdl.handle.net/2152/1188.
Council of Science Editors:
Beckner, Victoria Lemle 1. The effects of stress on different stages of memory. [Doctoral Dissertation]. University of Texas – Austin; 2004. Available from: http://hdl.handle.net/2152/1188
University of British Columbia
26.
Allan , Gerald D.
Measurement of plasma cortisol and histometry of the interrenal gland of juvenile pre-smolt coho salmon (Oncorhynchus kisutch Walbaum) during cold temperature acclimation.
Degree: MS- MSc, Zoology, 1971, University of British Columbia
URL: http://hdl.handle.net/2429/33663
► Juvenile, pre-smolt coho salmon were subjected to a decrease in environmental temperature from 12°C (temperature of acclimation) to 2°C over a period of approximately 72…
(more)
▼ Juvenile, pre-smolt coho salmon were subjected to a decrease in environmental temperature from 12°C (temperature of acclimation) to 2°C over a period of approximately 72 hours. During this time, plasma Cortisol values were estimated by the competitive protein binding (CPB) technique. In addition, an histometric analysis of the interrenal tissues of these fishes was performed as a measure of interregnal activity. Experimental results indicated that fluctuations in plasma Cortisol concentrations occurred within 120 hours of the initiation of temperature alteration. Control levels for plasma Cortisol were 2.9 ± 0.75 ug cortiso1/100 ml plasma (mean ±S.D.). Maximum plasma Cortisol concentration, observed at hour 84 after temperature alteration, was 27.0 ± 2.8 ug cortisol/100 ml plasma (mean ± S.E.). By hour 96 experimental cortisol values returned to a level just slightly above those of controls and did not change significantly after that time.
Measurements of interrenal nuclear diameters showed a significant increase in interrenal activity 14 days after initiation of exposure to cold. This level of interrenal activity was maintained until the experiment was terminated (20 days exposure to cold).
It is concluded from this study that during acclimation to cold temperature, plasma cortisol values of juvenile, pre-smolt coho salmon demonstrate an early and rapid increase (within 120 hours exposure to colder temperature) followed by an equally rapid decrease to a level just slightly above that of controls. Furthermore, it is concluded that juvenile, pre-smolt coho salmon treated in this manner show no histologically demonstrable increase in interrenal activity until well after plasma cortisol values have become stabilized at a level slightly above that of controls (14 days exposure to cold).
Subjects/Keywords: Coho salmon; Cortisone; Hydrocortisone
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Allan , G. D. (1971). Measurement of plasma cortisol and histometry of the interrenal gland of juvenile pre-smolt coho salmon (Oncorhynchus kisutch Walbaum) during cold temperature acclimation. (Masters Thesis). University of British Columbia. Retrieved from http://hdl.handle.net/2429/33663
Chicago Manual of Style (16th Edition):
Allan , Gerald D. “Measurement of plasma cortisol and histometry of the interrenal gland of juvenile pre-smolt coho salmon (Oncorhynchus kisutch Walbaum) during cold temperature acclimation.” 1971. Masters Thesis, University of British Columbia. Accessed January 19, 2021.
http://hdl.handle.net/2429/33663.
MLA Handbook (7th Edition):
Allan , Gerald D. “Measurement of plasma cortisol and histometry of the interrenal gland of juvenile pre-smolt coho salmon (Oncorhynchus kisutch Walbaum) during cold temperature acclimation.” 1971. Web. 19 Jan 2021.
Vancouver:
Allan GD. Measurement of plasma cortisol and histometry of the interrenal gland of juvenile pre-smolt coho salmon (Oncorhynchus kisutch Walbaum) during cold temperature acclimation. [Internet] [Masters thesis]. University of British Columbia; 1971. [cited 2021 Jan 19].
Available from: http://hdl.handle.net/2429/33663.
Council of Science Editors:
Allan GD. Measurement of plasma cortisol and histometry of the interrenal gland of juvenile pre-smolt coho salmon (Oncorhynchus kisutch Walbaum) during cold temperature acclimation. [Masters Thesis]. University of British Columbia; 1971. Available from: http://hdl.handle.net/2429/33663
27.
Lohrman, Charles Richard.
The early effects of cortisol on 3H-uridine and 14C-leucine uptake and incorporation in cell line I-407.
Degree: 1977, NC Docks
URL: http://libres.uncg.edu/ir/uncg/f/lohrman_charles_1977.pdf
► The purpose of this study was to investigate the effect of cortisol on uridine and leucine metabolism in cell line 1-407. Experiments were performed to…
(more)
▼ The purpose of this study was to investigate the effect of cortisol on uridine and leucine metabolism in cell line 1-407. Experiments were performed to determine the early effects of cortisol on the cells. Monolayered cell cultures were exposed to cortisol, labelled precursors such as 3H-uridine and 14C-leucine and metabolic inhibitors. These cells were then homogenized and subjected to trichloroacetic acid (TCA) separation. Radioactive precursors in the TCA-soluble and insoluble fractions acted as a measure of precursor uptake and incorporation. Preparatory experiments were performed to determine the fetal bovine serum (FBS) concentration for optimal cell growth. These experiments were also used to determine the cortisol concentration which produced the most consistent response. It was observed that cells grew best in 10% FBS. The lowest cortisol concentration which produced a consistently reproducible response in the cells was 0.05 ug/ml (1.7 x 10-7). This study demonstrated, for the first time, the early and continuous parallel hormonal response to uridine uptake and incorporation in an in vitro cell system. Cortisol stimulated an early (15 minute) increase in both uptake and incorporation of 3H-uridine followed by a rapid decrease at 30 minutes. The results of longer hormone incubations (2-4 hours) showed a decrease in specific activity of 3H-nucleoside in both TCA-soluble and TCA-insoluble fractions
Subjects/Keywords: Hydrocortisone; Metabolism; Uridine; Leucine
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Lohrman, C. R. (1977). The early effects of cortisol on 3H-uridine and 14C-leucine uptake and incorporation in cell line I-407. (Thesis). NC Docks. Retrieved from http://libres.uncg.edu/ir/uncg/f/lohrman_charles_1977.pdf
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Lohrman, Charles Richard. “The early effects of cortisol on 3H-uridine and 14C-leucine uptake and incorporation in cell line I-407.” 1977. Thesis, NC Docks. Accessed January 19, 2021.
http://libres.uncg.edu/ir/uncg/f/lohrman_charles_1977.pdf.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Lohrman, Charles Richard. “The early effects of cortisol on 3H-uridine and 14C-leucine uptake and incorporation in cell line I-407.” 1977. Web. 19 Jan 2021.
Vancouver:
Lohrman CR. The early effects of cortisol on 3H-uridine and 14C-leucine uptake and incorporation in cell line I-407. [Internet] [Thesis]. NC Docks; 1977. [cited 2021 Jan 19].
Available from: http://libres.uncg.edu/ir/uncg/f/lohrman_charles_1977.pdf.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Lohrman CR. The early effects of cortisol on 3H-uridine and 14C-leucine uptake and incorporation in cell line I-407. [Thesis]. NC Docks; 1977. Available from: http://libres.uncg.edu/ir/uncg/f/lohrman_charles_1977.pdf
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Michigan State University
28.
Guseman, Emily Hill.
Physical activity, daily cortisol patterns and the metabolic syndrome in obese adolescents.
Degree: 2012, Michigan State University
URL: http://etd.lib.msu.edu/islandora/object/etd:641
► Thesis Ph. D. Michigan State University, Kinesiology 2012.
The influence of cortisol and stress in the development of obesity and metabolic syndrome has received increased…
(more)
▼ Thesis Ph. D. Michigan State University, Kinesiology 2012.
The influence of cortisol and stress in the development of obesity and metabolic syndrome has received increased interest in recent years due to the high prevalence of overweight and obesity in children, youth, and adults. Some studies suggest that physical activity may attenuate the relationship between stress and metabolic syndrome, but more studies are necessary to fully understand this relationship. Many studies have shown a relationship between stress and metabolic syndrome using survey measures, but researchers have not linked survey measures to HPA axis activity. Therefore, the purpose of this study was to examine the relationship between stress (using daily cortisol and survey measures) and metabolic syndrome in obese youth, and to examine the potential moderating effects of physical activity on that relationship. METHODS: Obese adolescents were recruited from the Healthy Weight Center (HWC) and Academic General Pediatrics (AGP) clinics at Helen DeVos Children's Hospital in Grand Rapids, MI. Height, weight, waist circumference, blood pressure, and pubertal stage were obtained at the time of a routine clinic visit, and BMI was calculated. Participants completed the Pediatric Symptom Checklist (PSC) to evaluate psychosocial function (stress). Physical activity (steps/day and minutes per day spent in moderate-to-vigorous physical activity - MVPA) was monitored using the SenseWear Pro III armband (SWA). Participants provided saliva samples (while at home on a weekend day) that were taken at prescribed times: 1) immediately upon waking; 2) 30-minutes after waking; 3) 3 hours after waking; 4) 6 hours after waking; 5) 9 hours after waking; 6) 12 hours after waking. Fasting measures of HDL cholesterol, triglycerides, and glucose were obtained from physician-ordered blood draws and used with waist circumference and systolic blood pressure to calculate a continuous metabolic syndrome risk score (cMetS). RESULTS: A total of 50 subjects (15 boys, 35 girls; mean age 14.8 ± 1.9 y) agreed to participate. The mean cMetS score was 4.16 ± 4.30 and did not differ by clinic or sex. Subjects participated in approximately 46 min of moderate-to-vigorous physical activity per day. Mean cAUC was 1.337 ± 0.867 ug/dl (1.180 ± 0.753 ug/dl and 1.408 ± 0.922 ug/dl for males and females, respectively) and did not differ by sex or clinic. No significant relationship was found between cAUC and cMetS (R2=0.113, p=0.66). Additionally, neither the interactions of steps/day nor MVPA with cAUC significantly predicted cMetS. Partial correlations revealed a significant inverse relationship between PSC total score and cAUC (r=-0.45, p=0.04). Significant inverse relationships were also found between cAUC and PSC total score, internalizing score, and externalizing score, as well as between all three PSC scores and cortisol sample 2. Finally, no significant relationship was found between PSC score and cMetS, nor was there a significant moderating effect of steps/day or MVPA on this…
Advisors/Committee Members: Pfeiffer, Karin A, Pivarnik, James, Carlson, Joseph C, Stansbury, Kathy.
Subjects/Keywords: Overweight teenagers; Exercise – Teenagers; Hydrocortisone – Secretions – Regulation; Metabolism – Disorders; Kinesiology
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Guseman, E. H. (2012). Physical activity, daily cortisol patterns and the metabolic syndrome in obese adolescents. (Thesis). Michigan State University. Retrieved from http://etd.lib.msu.edu/islandora/object/etd:641
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Guseman, Emily Hill. “Physical activity, daily cortisol patterns and the metabolic syndrome in obese adolescents.” 2012. Thesis, Michigan State University. Accessed January 19, 2021.
http://etd.lib.msu.edu/islandora/object/etd:641.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Guseman, Emily Hill. “Physical activity, daily cortisol patterns and the metabolic syndrome in obese adolescents.” 2012. Web. 19 Jan 2021.
Vancouver:
Guseman EH. Physical activity, daily cortisol patterns and the metabolic syndrome in obese adolescents. [Internet] [Thesis]. Michigan State University; 2012. [cited 2021 Jan 19].
Available from: http://etd.lib.msu.edu/islandora/object/etd:641.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Guseman EH. Physical activity, daily cortisol patterns and the metabolic syndrome in obese adolescents. [Thesis]. Michigan State University; 2012. Available from: http://etd.lib.msu.edu/islandora/object/etd:641
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
29.
Josineire Melo Costa Sallum.
Estudo Comparativo do Potencial AntiinflamatÃrio do Diclofenaco de PotÃssio e da Hidrocortisona no Eritema Solar.
Degree: Master, 2007, Universidade Federal do Ceará
URL: http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=9612
;
► HÃ evidÃncias de que a radiaÃÃo UV provoca liberaÃÃo de molÃculas mediadoras da inflamaÃÃo, molÃculas estas responsÃveis pelo desencadeamento de algumas reaÃÃes bioquÃmicas que originam…
(more)
▼ HÃ evidÃncias de que a radiaÃÃo UV provoca liberaÃÃo de molÃculas mediadoras da inflamaÃÃo, molÃculas estas responsÃveis pelo desencadeamento de algumas reaÃÃes bioquÃmicas que originam o eritema (L.Pons Gimier; J.L.Parra Juez,2005).
O eritema à uma resposta fisiolÃgica muito complexa, composta por inÃmeras variÃveis que o influencia. Se apresenta com uma coloraÃÃo avermelhada da pele, desaparecendo à digitopressÃo. O eritema por rubor, à devido à vasodilataÃÃo arterial ativa, com aumento de temperatura, decorrente de um processo inflamatÃrio, no caso a radiaÃÃo solar. (Sampaio, 2000).
O FPS Ã definido como a razÃo entre a quantidade de energia necessÃria para produzir um grau de eritema mÃnimo na pele protegida com o filtro solar, e a quantidade de energia que leva ao mesmo grau de eritema na pele nÃo protegida.
Neste estudo clÃnico, duplo-cego, aleatorizado, comparativo e controlado teve como objetivo avaliar o efeito antiinflamatÃrio dos medicamentos Diclofenaco e da Hidrocortisona no tratamento preventivo e no tratamento curativo de eritema solar em voluntÃrias sadias e com fotipos de pele I,II e III segundo PATHAK,1983.
Dois grupos de 10 voluntÃrias cada participaram deste estudo: um grupo para a determinaÃÃo do efeito antiinflamatÃrio curativo e preventivo do Diclofenaco dietilamÃnio, e outro grupo, para a determinaÃÃo do efeito antiinflamatÃrio curativo e preventivo da Hidrocortisona em eritema solar. Foram demarcadas quatro Ãreas nas regiÃes infraescapular de cada voluntÃria duas para tratamento curativo e controle e duas para o tratamento preventivo e o controle.
Como fonte de irradiaÃÃo de luz ultravioleta foi utilizado um Simulador de Arco Solar- Multisport. Para a leitura dos eritemas foi utilizado o Mexameter, equipamento que quantifica a melanina e a hemoglobina.
There is evidence that UV radiation causes the release of mediators of inflammation molecules, these molecules responsible for triggering some of the biochemical reactions that cause erythema (L.Pons Gimier; JLParra Juez, 2005).
Erythema is a physiological response very complex, composed of many variables that influence. Presents with a reddish skin, disappearing digital pressure. Erythema by flushing is due to arterial vasodilation active with increasing temperature, due to an inflammatory process, if the solar radiation. (Sampaio, 2000).
The SPF is defined as the ratio between the amount of energy required to produce minimal erythema on the degree of protected skin with the sunscreen, and the amount of energy it takes the same level of erythema on unprotected skin.
In this clinical study, double-blind, randomized, comparative, controlled aimed to evaluate the anti-inflammatory drug diclofenac and hydrocortisone treatment in preventive and remedial treatment of sunburn in healthy volunteers and fotipos skin I, II and III Pathak, 1983.
Two groups of each 10 volunteers participated in this study: one group to determine the curative and preventive anti-inflammatory effects of Diclofenac diethylammonium, and the other, for…
Advisors/Committee Members: Francisco Vagnaldo Fechine Jamacaru, Gisela Costa CamarÃo, Maria Elisabete Amaral de Moraes.
Subjects/Keywords: FARMACOLOGIA CLINICA; Eritema; Diclofenaco; Hidrocortisona; Ensaio ClÃnico
; Solar Erythema; Diclofenac; Hydrocortisone; Clinical Trial
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Sallum, J. M. C. (2007). Estudo Comparativo do Potencial AntiinflamatÃrio do Diclofenaco de PotÃssio e da Hidrocortisona no Eritema Solar. (Masters Thesis). Universidade Federal do Ceará. Retrieved from http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=9612 ;
Chicago Manual of Style (16th Edition):
Sallum, Josineire Melo Costa. “Estudo Comparativo do Potencial AntiinflamatÃrio do Diclofenaco de PotÃssio e da Hidrocortisona no Eritema Solar.” 2007. Masters Thesis, Universidade Federal do Ceará. Accessed January 19, 2021.
http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=9612 ;.
MLA Handbook (7th Edition):
Sallum, Josineire Melo Costa. “Estudo Comparativo do Potencial AntiinflamatÃrio do Diclofenaco de PotÃssio e da Hidrocortisona no Eritema Solar.” 2007. Web. 19 Jan 2021.
Vancouver:
Sallum JMC. Estudo Comparativo do Potencial AntiinflamatÃrio do Diclofenaco de PotÃssio e da Hidrocortisona no Eritema Solar. [Internet] [Masters thesis]. Universidade Federal do Ceará 2007. [cited 2021 Jan 19].
Available from: http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=9612 ;.
Council of Science Editors:
Sallum JMC. Estudo Comparativo do Potencial AntiinflamatÃrio do Diclofenaco de PotÃssio e da Hidrocortisona no Eritema Solar. [Masters Thesis]. Universidade Federal do Ceará 2007. Available from: http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=9612 ;
Universidade Estadual de Campinas
30.
Mahn, Paulo Ângelo, 1969-.
Ansiedade, qualidade do sono e concentração de cortisol salivar em tenistas adolescentes.
Degree: 2013, Universidade Estadual de Campinas
URL: http://repositorio.unicamp.br/jspui/handle/REPOSIP/287943
► Abstract: Among the various psychological factors that influence the performance of athletes of high rate sport performances, anxiety has been one of the most crucial.…
(more)
▼ Abstract: Among the various psychological factors that influence the performance of athletes of high rate sport performances, anxiety has been one of the most crucial. In tennis, the high competitiveness among athletes, associated with the individuality, is a generator of anxiety. The sleep-related habits can influence an athletes' performance. The hormone cortisol is considered an important indicator of anxiety in competitions, since its production and secretion are increased before, during and after competitive events. The aim of this study was to assess levels of psychological and physiological anxiety and the quality of sleep in young tennis players, in two trainings and in the first round of the regional tournament and in the first round of the state tournament. The sample was composed by 20 males adolescent players aged from 15 to 18 years. The Brazilian versions of the Beck Anxiety Inventory and the Mini Sleep Questionnaire were applied before the 1st training for psychological assessment of anxiety and sleep quality; and levels of salivary cortisol were used to assess the physiological anxiety. The saliva samples were collected in 4 periods: 1st - training; 2nd - regional tournament; 3rd - training; 4th - state tournament, obtaining three samples in each period: 1 - Upon awakening, 2 - Five minutes before the tournament or training; 3 - Between the 1st and 2nd sets. The cortisol was measured by enzyme immunoassay. The results showed that the psychological anxiety ranged from minimal to moderate. The quality of sleep reported great variability. There was no significant difference in salivary cortisol values among the three sampling times in the first training and in the regional tournament. During the 2nd training, the values of salivary cortisol, 5 minutes before the match were similar to those at awakening with a significant decline of the 1st and 2nd sets compared with the previous concentrations. The comparison between the 1st and the 2nd trainings showed no significant difference in the values of salivary cortisol at 5 minutes before match, but with a higher value in the 2nd training. This difference was not perceived as significant at waking up and between the 1st and the 2nd set. In the state tournament before the match and between the 1st and 2nd sets, the cortisol values were similar to each other, and significantly higher than those at awakening. The salivary cortisol concentrations at 5 minutes before the match and xii between the 1st and 2nd sets were significantly higher in the state tournament compared with the regional one. There was no association among sleep quality and anxiety levels and the fact of having been defeated at least in one training and/or one tournament. Concluding, it can be suggested that athletes may have been affected by the challenge, since the cortisol concentrations were higher in the state tournament and training in relation to the values upon awakening and in relation to the regional one
Advisors/Committee Members: UNIVERSIDADE ESTADUAL DE CAMPINAS (CRUESP), Gavião, Maria Beatriz Duarte, 1955- (advisor), Universidade Estadual de Campinas. Faculdade de Odontologia de Piracicaba (institution), Programa de Pós-Graduação em Biologia Buco-Dental (nameofprogram), Strini, Paulinne Junqueira Silva Andresen (committee member), Franco, Mariana Trevisani Arthuri (committee member), Prado, Felippe Bevilacqua (committee member), Barbosa, Taís de Souza (committee member).
Subjects/Keywords: Hidrocortisona; Competição (Esporte); Atletas; Esportes; Jovens; Hydrocortisone; Competition (Sport); Athetes; Sports; Young
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Mahn, Paulo Ângelo, 1. (2013). Ansiedade, qualidade do sono e concentração de cortisol salivar em tenistas adolescentes. (Thesis). Universidade Estadual de Campinas. Retrieved from http://repositorio.unicamp.br/jspui/handle/REPOSIP/287943
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Mahn, Paulo Ângelo, 1969-. “Ansiedade, qualidade do sono e concentração de cortisol salivar em tenistas adolescentes.” 2013. Thesis, Universidade Estadual de Campinas. Accessed January 19, 2021.
http://repositorio.unicamp.br/jspui/handle/REPOSIP/287943.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Mahn, Paulo Ângelo, 1969-. “Ansiedade, qualidade do sono e concentração de cortisol salivar em tenistas adolescentes.” 2013. Web. 19 Jan 2021.
Vancouver:
Mahn, Paulo Ângelo 1. Ansiedade, qualidade do sono e concentração de cortisol salivar em tenistas adolescentes. [Internet] [Thesis]. Universidade Estadual de Campinas; 2013. [cited 2021 Jan 19].
Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/287943.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Mahn, Paulo Ângelo 1. Ansiedade, qualidade do sono e concentração de cortisol salivar em tenistas adolescentes. [Thesis]. Universidade Estadual de Campinas; 2013. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/287943
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
◁ [1] [2] [3] [4] [5] ▶
. 
Open Access Theses and Dissertations