subject:(Hippocampus)

Wake Forest University

1. Haynes, Kathryn Alice. The Role of Ubiquitin-Proteasome-Mediated Proteolysis in Long-term Synaptic Plasticity.

Degree: 2015, Wake Forest University

► Elucidating mechanisms by which synapses are modified for long-term memory storage is crucial for explaining normal brain function as well as diseases and disorders of… (more)

▼ Elucidating mechanisms by which synapses are modified for long-term memory storage is crucial for explaining normal brain function as well as diseases and disorders of the brain. Numerous studies have shown that new gene expression and new protein synthesis are essential for the synaptic changes that give rise to long-term memory. More recent studies indicate that proteolysis by the ubiquitin-proteasome pathway (UPP) plays a critical role in long-term synaptic plasticity, and dysregulation of this pathway is associated with cognitive impairments in neurodegenerative diseases such as Alzheimer’s, Parkinson’s, and Huntington’s disease. Using the cellular model for long-term synaptic plasticity, late-phase long-term potentiation (L-LTP), our work reveals intricate interactions between proteolysis, protein synthesis in the dendrites and gene transcription in the nucleus. Previously, we showed that the early induction phase of L-LTP, which depends on local protein synthesis within dendrites, is enhanced by proteasome inhibition. We also observed that the later maintenance phase of L-LTP, which relies on translation of newly transcribed mRNAs, is blocked when the proteasome is inhibited. We hypothesized that the proteasome must be regulating both phases of L-LTP by controlling translation within dendrites and transcription within the nucleus. Supporting this hypothesis, we found two translational activators that increase early in L-LTP and two translational repressors that buildup later in L-LTP. Inhibition of the proteasome prior to L-LTP resulted in significant increases in expression of both translation activators and repressors, suggesting that this temporal regulation of translation might contribute to the proteasome’s role in the regulation of L-LTP induction and maintenance. In addition, proteasome inhibition prior to LTP induction significantly increases overall protein synthesis and initially slows protein degradation. Interestingly, we also found that amyloid –β (Aβ) drastically decreases basal and activity-dependent protein synthesis, while proteasome inhibition prior to Aβ treatment rescues this decrease back to control and LTP levels, respectively. Finally, taking a step away from translation and investigating the role of the proteasome in transcriptional regulation, we found that a transcriptional repressor, ATF4, is phosphorylated and degraded early in LTP, indicating a potential critical role for the proteasome in relieving repression of transcription during memory consolidation. These findings shed light on the proteasome-dependent mechanisms behind gene and protein expression in synaptic plasticity and could aide in finding novel therapeutic targets and biomarkers for ameliorating memory impairments in neurodegenerative diseases.

Subjects/Keywords: Hippocampus

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APA (6^th Edition):

Haynes, K. A. (2015). The Role of Ubiquitin-Proteasome-Mediated Proteolysis in Long-term Synaptic Plasticity. (Thesis). Wake Forest University. Retrieved from http://hdl.handle.net/10339/57156

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Haynes, Kathryn Alice. “The Role of Ubiquitin-Proteasome-Mediated Proteolysis in Long-term Synaptic Plasticity.” 2015. Thesis, Wake Forest University. Accessed February 26, 2021. http://hdl.handle.net/10339/57156.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Haynes, Kathryn Alice. “The Role of Ubiquitin-Proteasome-Mediated Proteolysis in Long-term Synaptic Plasticity.” 2015. Web. 26 Feb 2021.

Vancouver:

Haynes KA. The Role of Ubiquitin-Proteasome-Mediated Proteolysis in Long-term Synaptic Plasticity. [Internet] [Thesis]. Wake Forest University; 2015. [cited 2021 Feb 26]. Available from: http://hdl.handle.net/10339/57156.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Haynes KA. The Role of Ubiquitin-Proteasome-Mediated Proteolysis in Long-term Synaptic Plasticity. [Thesis]. Wake Forest University; 2015. Available from: http://hdl.handle.net/10339/57156

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Texas – Austin

2. Clemens, Ann M. Adaptive responses to cellular stress in neurons of the hippocampus.

Degree: PhD, Neuroscience, 2013, University of Texas – Austin

URL: http://hdl.handle.net/2152/26613

► Disruptions of endoplasmic reticulum (ER) Ca²⁺ homeostasis are heavily linked to neuronal pathology. Depletion of ER Ca²⁺ stores can result in cellular dysfunction and potentially… (more)

Subjects/Keywords: Hippocampus

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Clemens, A. M. (2013). Adaptive responses to cellular stress in neurons of the hippocampus. (Doctoral Dissertation). University of Texas – Austin. Retrieved from http://hdl.handle.net/2152/26613

Chicago Manual of Style (16^th Edition):

Clemens, Ann M. “Adaptive responses to cellular stress in neurons of the hippocampus.” 2013. Doctoral Dissertation, University of Texas – Austin. Accessed February 26, 2021. http://hdl.handle.net/2152/26613.

MLA Handbook (7^th Edition):

Clemens, Ann M. “Adaptive responses to cellular stress in neurons of the hippocampus.” 2013. Web. 26 Feb 2021.

Vancouver:

Clemens AM. Adaptive responses to cellular stress in neurons of the hippocampus. [Internet] [Doctoral dissertation]. University of Texas – Austin; 2013. [cited 2021 Feb 26]. Available from: http://hdl.handle.net/2152/26613.

Council of Science Editors:

Clemens AM. Adaptive responses to cellular stress in neurons of the hippocampus. [Doctoral Dissertation]. University of Texas – Austin; 2013. Available from: http://hdl.handle.net/2152/26613

Brandeis University

3. Sanders, Honi. Perspectives on Computation in Oscillatory Networks in the Brain.

Degree: 2016, Brandeis University

URL: http://hdl.handle.net/10192/32067

► This thesis explores possible roles of oscillations in the brain. Computer simulations demonstrate the robustness of dendritic voltage bistability, a mechanism for working mem- ory,… (more)

Subjects/Keywords: Neuroscience; Hippocampus

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APA (6^th Edition):

Sanders, H. (2016). Perspectives on Computation in Oscillatory Networks in the Brain. (Thesis). Brandeis University. Retrieved from http://hdl.handle.net/10192/32067

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Sanders, Honi. “Perspectives on Computation in Oscillatory Networks in the Brain.” 2016. Thesis, Brandeis University. Accessed February 26, 2021. http://hdl.handle.net/10192/32067.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Sanders, Honi. “Perspectives on Computation in Oscillatory Networks in the Brain.” 2016. Web. 26 Feb 2021.

Vancouver:

Sanders H. Perspectives on Computation in Oscillatory Networks in the Brain. [Internet] [Thesis]. Brandeis University; 2016. [cited 2021 Feb 26]. Available from: http://hdl.handle.net/10192/32067.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Sanders H. Perspectives on Computation in Oscillatory Networks in the Brain. [Thesis]. Brandeis University; 2016. Available from: http://hdl.handle.net/10192/32067

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

4. Toritsuka, Michihiro; Kimoto, Sohei; Muraki, Kazue; Landek-Salgado, Melissa A; Yoshida, Atsuhiro; Yamamoto, Norio; Horiuchi, Yasue; Hiyama, Hideki; Tajinda, Katsunori; Keni, Ni; Illingworth, Elizabeth; Iwamoto, Takashi; Kishimoto, Toshifumi; Sawa, Akira. Deficits in microRNA-mediated Cxcr4/Cxcl12 signaling in neurodevelopmental deficits in a 22q11 deletion syndrome mouse model. : 22q11欠失症候群モデルマウスの神経発達障害には、マイクロRNAが介在するCxcr4/Cxcl12シグナリングの欠損が寄与する.

Degree: 博士（医学）, 2014, Nara Medical University / 奈良県立医科大学

URL: http://hdl.handle.net/10564/2716

►

22q11 deletion syndrome (22q11DS) frequently accompanies psychiatric conditions, some of which are classified as schizophrenia and bipolar disorder in the current diagnostic categorization. However, it… (more)

Subjects/Keywords: hippocampus; dentate gyrus

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APA (6^th Edition):

Toritsuka, Michihiro; Kimoto, Sohei; Muraki, Kazue; Landek-Salgado, Melissa A; Yoshida, Atsuhiro; Yamamoto, Norio; Horiuchi, Yasue; Hiyama, Hideki; Tajinda, Katsunori; Keni, Ni; Illingworth, Elizabeth; Iwamoto, Takashi; Kishimoto, Toshifumi; Sawa, A. (2014). Deficits in microRNA-mediated Cxcr4/Cxcl12 signaling in neurodevelopmental deficits in a 22q11 deletion syndrome mouse model. : 22q11欠失症候群モデルマウスの神経発達障害には、マイクロRNAが介在するCxcr4/Cxcl12シグナリングの欠損が寄与する. (Thesis). Nara Medical University / 奈良県立医科大学. Retrieved from http://hdl.handle.net/10564/2716

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Toritsuka, Michihiro; Kimoto, Sohei; Muraki, Kazue; Landek-Salgado, Melissa A; Yoshida, Atsuhiro; Yamamoto, Norio; Horiuchi, Yasue; Hiyama, Hideki; Tajinda, Katsunori; Keni, Ni; Illingworth, Elizabeth; Iwamoto, Takashi; Kishimoto, Toshifumi; Sawa, Akira. “Deficits in microRNA-mediated Cxcr4/Cxcl12 signaling in neurodevelopmental deficits in a 22q11 deletion syndrome mouse model. : 22q11欠失症候群モデルマウスの神経発達障害には、マイクロRNAが介在するCxcr4/Cxcl12シグナリングの欠損が寄与する.” 2014. Thesis, Nara Medical University / 奈良県立医科大学. Accessed February 26, 2021. http://hdl.handle.net/10564/2716.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Toritsuka, Michihiro; Kimoto, Sohei; Muraki, Kazue; Landek-Salgado, Melissa A; Yoshida, Atsuhiro; Yamamoto, Norio; Horiuchi, Yasue; Hiyama, Hideki; Tajinda, Katsunori; Keni, Ni; Illingworth, Elizabeth; Iwamoto, Takashi; Kishimoto, Toshifumi; Sawa, Akira. “Deficits in microRNA-mediated Cxcr4/Cxcl12 signaling in neurodevelopmental deficits in a 22q11 deletion syndrome mouse model. : 22q11欠失症候群モデルマウスの神経発達障害には、マイクロRNAが介在するCxcr4/Cxcl12シグナリングの欠損が寄与する.” 2014. Web. 26 Feb 2021.

Vancouver:

Toritsuka, Michihiro; Kimoto, Sohei; Muraki, Kazue; Landek-Salgado, Melissa A; Yoshida, Atsuhiro; Yamamoto, Norio; Horiuchi, Yasue; Hiyama, Hideki; Tajinda, Katsunori; Keni, Ni; Illingworth, Elizabeth; Iwamoto, Takashi; Kishimoto, Toshifumi; Sawa A. Deficits in microRNA-mediated Cxcr4/Cxcl12 signaling in neurodevelopmental deficits in a 22q11 deletion syndrome mouse model. : 22q11欠失症候群モデルマウスの神経発達障害には、マイクロRNAが介在するCxcr4/Cxcl12シグナリングの欠損が寄与する. [Internet] [Thesis]. Nara Medical University / 奈良県立医科大学; 2014. [cited 2021 Feb 26]. Available from: http://hdl.handle.net/10564/2716.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Toritsuka, Michihiro; Kimoto, Sohei; Muraki, Kazue; Landek-Salgado, Melissa A; Yoshida, Atsuhiro; Yamamoto, Norio; Horiuchi, Yasue; Hiyama, Hideki; Tajinda, Katsunori; Keni, Ni; Illingworth, Elizabeth; Iwamoto, Takashi; Kishimoto, Toshifumi; Sawa A. Deficits in microRNA-mediated Cxcr4/Cxcl12 signaling in neurodevelopmental deficits in a 22q11 deletion syndrome mouse model. : 22q11欠失症候群モデルマウスの神経発達障害には、マイクロRNAが介在するCxcr4/Cxcl12シグナリングの欠損が寄与する. [Thesis]. Nara Medical University / 奈良県立医科大学; 2014. Available from: http://hdl.handle.net/10564/2716

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Tulane University

5. Homiack, Damek. Mechanisms by which Acute or Chronic Stress Exposure Modulates CREB Phosphorylation in the Hippocampus in a Sex-Specific Manner.

Degree: 2017, Tulane University

URL: https://digitallibrary.tulane.edu/islandora/object/tulane:75315

►

Women are at greater risk to develop the incurable psychiatric diseases posttraumatic stress disorder (PTSD) and major depressive disorder (MDD). In spite of the elevated… (more)

▼

Women are at greater risk to develop the incurable psychiatric diseases posttraumatic stress disorder (PTSD) and major depressive disorder (MDD). In spite of the elevated risk associated with female biological sex, the vast majority of preclinical studies have exclusively used male rodents. Therefore, the neurobiology which underlies the increased susceptibility to stress-related mental illness associated with female sex is largely unknown. Currently, it is thought that regulation of the transcription factor cyclic-AMP response element binding protein (CREB) may act as a molecular locus capable of transducing aversive experiences into lasting changes in the structure and function of neurons in the hippocampus. However, the signal transduction cascades recruited by stress to modulate CREB activity are less well understood. Therefore, the goal of this thesis was to investigate stress-induced modulation of CREB phosphorylation and upstream signaling cascades in the hippocampus of male and female rodents exposed to severe stress. Exposure to either acute predator odor stress or chronic variable stress reduced phosphorylation of CREB in the male, but not the female hippocampus. Predator odor exposure rapidly reduced phosphorylation of extracellular signal-regulated kinase and increased nuclear expression of the synapto-nuclear messenger protein Jacob in the male hippocampus, consistent with the previously described CREB shut-off cascade. Chronic variable stress affected the activity of Sirtuin1, a metabolically-sensitive deacetylase known to interact with CREB, in the male, but not the female dentate gyrus sub-area of the hippocampus, possibly through recruitment of adenosine monophosphate activated protein kinase. Behaviorally, female rodents exposed to predator odor exhibited an impaired ability to discriminate between a context previously paired with the predator odor and a neutral context, possibly representing a fear over-generalizing phenotype. In contrast female rodents exposed to chronic variable stress did not exhibit the altered metabolic phenotypes observed in male rodents exposed to chronic variable stress, suggesting that females are more resilient to chronic stress. Collectively, these data suggest that the female hippocampus resists changes in CREB phosphorylation associated with severe stress which may contribute to sex differences observed in stress-related mental health disorders.

1

Damek Homiack

Advisors/Committee Members: (author), Schrader, Laura (Thesis advisor), (Thesis advisor), School of Science & Engineering Neuroscience (Degree granting institution), NULL (Degree granting institution).

Subjects/Keywords: Hippocampus; CREB; Stress

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Homiack, D. (2017). Mechanisms by which Acute or Chronic Stress Exposure Modulates CREB Phosphorylation in the Hippocampus in a Sex-Specific Manner. (Thesis). Tulane University. Retrieved from https://digitallibrary.tulane.edu/islandora/object/tulane:75315

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Homiack, Damek. “Mechanisms by which Acute or Chronic Stress Exposure Modulates CREB Phosphorylation in the Hippocampus in a Sex-Specific Manner.” 2017. Thesis, Tulane University. Accessed February 26, 2021. https://digitallibrary.tulane.edu/islandora/object/tulane:75315.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Homiack, Damek. “Mechanisms by which Acute or Chronic Stress Exposure Modulates CREB Phosphorylation in the Hippocampus in a Sex-Specific Manner.” 2017. Web. 26 Feb 2021.

Vancouver:

Homiack D. Mechanisms by which Acute or Chronic Stress Exposure Modulates CREB Phosphorylation in the Hippocampus in a Sex-Specific Manner. [Internet] [Thesis]. Tulane University; 2017. [cited 2021 Feb 26]. Available from: https://digitallibrary.tulane.edu/islandora/object/tulane:75315.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Homiack D. Mechanisms by which Acute or Chronic Stress Exposure Modulates CREB Phosphorylation in the Hippocampus in a Sex-Specific Manner. [Thesis]. Tulane University; 2017. Available from: https://digitallibrary.tulane.edu/islandora/object/tulane:75315

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Alberta

6. McEown, Kristopher. The roles of the dorsal and ventral hippocampus in fear and memory of a shock probe experience.

Degree: MS, Department of Psychology, 2009, University of Alberta

URL: https://era.library.ualberta.ca/files/2f75r905d

► This thesis examined the effects of temporary inactivation of the dorsal or ventral hippocampus on unconditioned and conditioned fear, using the shock-probe test. Rats received… (more)

Subjects/Keywords: fear; hippocampus; memory

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

McEown, K. (2009). The roles of the dorsal and ventral hippocampus in fear and memory of a shock probe experience. (Masters Thesis). University of Alberta. Retrieved from https://era.library.ualberta.ca/files/2f75r905d

Chicago Manual of Style (16^th Edition):

McEown, Kristopher. “The roles of the dorsal and ventral hippocampus in fear and memory of a shock probe experience.” 2009. Masters Thesis, University of Alberta. Accessed February 26, 2021. https://era.library.ualberta.ca/files/2f75r905d.

MLA Handbook (7^th Edition):

McEown, Kristopher. “The roles of the dorsal and ventral hippocampus in fear and memory of a shock probe experience.” 2009. Web. 26 Feb 2021.

Vancouver:

McEown K. The roles of the dorsal and ventral hippocampus in fear and memory of a shock probe experience. [Internet] [Masters thesis]. University of Alberta; 2009. [cited 2021 Feb 26]. Available from: https://era.library.ualberta.ca/files/2f75r905d.

Council of Science Editors:

McEown K. The roles of the dorsal and ventral hippocampus in fear and memory of a shock probe experience. [Masters Thesis]. University of Alberta; 2009. Available from: https://era.library.ualberta.ca/files/2f75r905d

Cornell University

7. Law, Loren. Contextual Learning In The Limbic Memory Circuit.

Degree: PhD, Psychology, 2015, Cornell University

URL: http://hdl.handle.net/1813/39373

► Context plays a critical role in memory. Information obtained during learning gets bound to the context and the context itself can serve as a potent… (more)

▼ Context plays a critical role in memory. Information obtained during learning gets bound to the context and the context itself can serve as a potent retrieval cue. It has been well known since the 1970's that the hippocampus (HP) plays a critical role in processing contextual information. Research has shown that learning two lists of items in two different contexts facilitates learning compared to learning both in one context, and damage to the HP abolishes this advantage. Electrophysiology studies have indicated the HP forms contextual representations of an environment quickly and that the representation remains stable thereafter. The HP also encodes non-spatial information such as events, cues and time. The HP and AT are strongly interconnected and it is well known now that damage to the anterior thalamic nuclei (AT) produces severe memory deficits in multiple memory domains similar that following damage to the HP. However, it is not known whether the AT is critically involved in contextual memory processes like the HP. The first chapter evaluated whether the AT is involved in contextual learning of a context dependent odor discrimination task. The results showed that like the HP, damage to the AT abolishes the contextual advantage of learning two sets of odor discrimination problems in separate contexts. The second chapter evaluated how neuronal representations in the HP change when learning two contexts concurrently. While studies have evaluated how neuronal representations change between context exposures, none have evaluated the concurrent development of two contexts. The results showed that several exposures to the same context are required to form a stable HP representation of the two contexts. The final iii chapter evaluated what event responses arise when learning the same task as chapter one and how these event representations change with learning. The results show that as learning progressed, event responses decreased in number. This decrease may be due to the responses becoming part of a general trial sequence indicating the stabilization of the representation as learning progressed. The current dissertation provides new evidence for how the memory circuit encodes contextual memory. iv Advisors/Committee Members: Smith, David M. (chair), Regan, Elizabeth (committee member), Devoogd, Timothy John (committee member), Cutting, James Eric (committee member).

Subjects/Keywords: Context; Hippocampus; elctrophysiology

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APA (6^th Edition):

Law, L. (2015). Contextual Learning In The Limbic Memory Circuit. (Doctoral Dissertation). Cornell University. Retrieved from http://hdl.handle.net/1813/39373

Chicago Manual of Style (16^th Edition):

Law, Loren. “Contextual Learning In The Limbic Memory Circuit.” 2015. Doctoral Dissertation, Cornell University. Accessed February 26, 2021. http://hdl.handle.net/1813/39373.

MLA Handbook (7^th Edition):

Law, Loren. “Contextual Learning In The Limbic Memory Circuit.” 2015. Web. 26 Feb 2021.

Vancouver:

Law L. Contextual Learning In The Limbic Memory Circuit. [Internet] [Doctoral dissertation]. Cornell University; 2015. [cited 2021 Feb 26]. Available from: http://hdl.handle.net/1813/39373.

Council of Science Editors:

Law L. Contextual Learning In The Limbic Memory Circuit. [Doctoral Dissertation]. Cornell University; 2015. Available from: http://hdl.handle.net/1813/39373

University of Texas Southwestern Medical Center

8. Bulin, Sarah Elizabeth. The Role of Adult Hippocampal Neurogenesis in Morphine Addiction.

Degree: 2015, University of Texas Southwestern Medical Center

URL: http://hdl.handle.net/2152.5/4130

► The hippocampus plays a large role in modulating the reward pathway, being especially important in craving and context-dependent relapse. One form a neuroplasticity within the… (more)

▼ The hippocampus plays a large role in modulating the reward pathway, being especially important in craving and context-dependent relapse. One form a neuroplasticity within the hippocampus is adult neurogenesis, which occurs in the subgranular zone of the dentate gyrus. While a growing amount of literature has explored the effects of drugs of abuse on adult DG neurogenesis, the relationship between self-administered opiates and adult DG neurogenesis remains unexplored. This dissertation investigates both the role of adult DG neurogenesis in morphine-related behaviors and the effects of self-administered opiates (morphine and heroin) on adult DG neurogenesis. I first explore the background literature important in the work completed within this dissertation (Chapter 1). Next, using a self-administration paradigm, I proceed to show that ablation of adult neurogenesis via cranial irradiation results in increased in morphine intake, decreased extinction, and decreased cognitive flexibility. Additionally, rats lacking adult DG neurogenesis exhibited increased morphine locomotor sensitization with increased DG activation in the infrablade after a low dose morphine challenge (Chapter 2). I will then go on to investigate the consequences of long-term self-administered opiates (morphine and heroin) on the different stages of maturation of adult-generated neurons. I demonstrate that morphine self-administration has no effect on proliferation, survival, or maturation immediately after exposure or after 28 days of withdrawal (Chapter 3). Additionally, I demonstrate that heroin self-administration does not alter DCX+ cell density or granule cell layer volume (Chapter 4). Taken together, my data suggests the adult DG neurogenesis is robust and normally unaffected by self-administered opiates. However, preexisting deficits in DG neurogenesis may lead to an increased vulnerability to addiction-related behaviors. In the final chapter (Chapter 5), I discuss potential implications of this work and future directions in which it may be taken. Advisors/Committee Members: Hsieh, Jenny, Self, David W., Powell, Craig M., Eisch, Amelia J..

Subjects/Keywords: Hippocampus; Morphine; Neurogenesis

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Bulin, S. E. (2015). The Role of Adult Hippocampal Neurogenesis in Morphine Addiction. (Thesis). University of Texas Southwestern Medical Center. Retrieved from http://hdl.handle.net/2152.5/4130

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Bulin, Sarah Elizabeth. “The Role of Adult Hippocampal Neurogenesis in Morphine Addiction.” 2015. Thesis, University of Texas Southwestern Medical Center. Accessed February 26, 2021. http://hdl.handle.net/2152.5/4130.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Bulin, Sarah Elizabeth. “The Role of Adult Hippocampal Neurogenesis in Morphine Addiction.” 2015. Web. 26 Feb 2021.

Vancouver:

Bulin SE. The Role of Adult Hippocampal Neurogenesis in Morphine Addiction. [Internet] [Thesis]. University of Texas Southwestern Medical Center; 2015. [cited 2021 Feb 26]. Available from: http://hdl.handle.net/2152.5/4130.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Bulin SE. The Role of Adult Hippocampal Neurogenesis in Morphine Addiction. [Thesis]. University of Texas Southwestern Medical Center; 2015. Available from: http://hdl.handle.net/2152.5/4130

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Texas Southwestern Medical Center

9. Perez, Jessica Marie. Hippocampal Subfield Transcriptome Analysis in Schizophrenia Psychosis.

Degree: 2018, University of Texas Southwestern Medical Center

URL: http://hdl.handle.net/2152.5/6147

► Schizophrenia is one of the thirty most incapacitating conditions in the world and affects tens of millions of people worldwide. Devastatingly, suicide occurs in 10%… (more)

▼ Schizophrenia is one of the thirty most incapacitating conditions in the world and affects tens of millions of people worldwide. Devastatingly, suicide occurs in 10% of those diagnosed with schizophrenia. Symptoms are persistent and often severe and available treatments are not curative. In fact, 20-33% of people with schizophrenia are entirely resistant to treatment. The complex symptom manifestations of schizophrenia lack a molecular pathology. Consequently, advances in novel treatment directions are limited. Schizophrenia is recognized as a polygenic disorder influenced by environmental factors. This dissertation aims to examine this polygenic nature of this disorder. Genome wide association studies have identified hundreds of common genetic variants, which individually confer a small risk for schizophrenia. However, all identified genetic variants combined only account for a modest amount of the total heritability of schizophrenia. In this dissertation, I capitalize on the unique ability of next-generation sequencing to identify in a global and unbiased manner molecular changes, which have not been previously hypothesized, but may contribute to the origin of the missing heritability of schizophrenia and play a role in schizophrenia symptomatology. The Tamminga lab has particular interest in schizophrenia psychosis, conceptualizing it as a disorder of learning and memory, critically involving dentate gyrus (DG), CA3, and CA1 of the hippocampus. Therefore, this doctoral dissertation examines the transcriptome of all three subfields, DG, CA3, and CA1 in human postmortem tissue of controls and individuals diagnosed with schizophrenia, using RNA-seq to identify additional psychosis-mediating molecular candidates and produce plausible targets for therapeutic treatment. After Chapters 1, 2, and 3 introduce the significance and contribution of this dissertation to the field of neuroscience in psychiatry, I show (Chapter 4) that each hippocampal subfield in schizophrenia has a unique molecular identity based on its transcriptome profile. As well, I show only slight effects of antipsychotic medication on schizophrenia-dependent gene changes in DG, CA3, and CA1. Taken together, my data identify molecular candidates and specific cell populations that we previously did not hypothesize as potential contributors to schizophrenia pathology. Finally, in Chapter 5, I outline future directions based on the contributions of my doctoral dissertation to the field. Advisors/Committee Members: Eisch, Amelia J., Tamminga, Carol, Kim, Tae-Kyung, Zinn, Andrew R..

Subjects/Keywords: Hippocampus; Schizophrenia; Transcriptome

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APA (6^th Edition):

Perez, J. M. (2018). Hippocampal Subfield Transcriptome Analysis in Schizophrenia Psychosis. (Thesis). University of Texas Southwestern Medical Center. Retrieved from http://hdl.handle.net/2152.5/6147

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Perez, Jessica Marie. “Hippocampal Subfield Transcriptome Analysis in Schizophrenia Psychosis.” 2018. Thesis, University of Texas Southwestern Medical Center. Accessed February 26, 2021. http://hdl.handle.net/2152.5/6147.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Perez, Jessica Marie. “Hippocampal Subfield Transcriptome Analysis in Schizophrenia Psychosis.” 2018. Web. 26 Feb 2021.

Vancouver:

Perez JM. Hippocampal Subfield Transcriptome Analysis in Schizophrenia Psychosis. [Internet] [Thesis]. University of Texas Southwestern Medical Center; 2018. [cited 2021 Feb 26]. Available from: http://hdl.handle.net/2152.5/6147.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Perez JM. Hippocampal Subfield Transcriptome Analysis in Schizophrenia Psychosis. [Thesis]. University of Texas Southwestern Medical Center; 2018. Available from: http://hdl.handle.net/2152.5/6147

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Otago

10. Seo, Steve. Spatial Learning-Induced Changes at Agmatinergic and Glutamatergic Synapses in the Hippocampal CA1 Region .

Degree: 2011, University of Otago

URL: http://hdl.handle.net/10523/1824

► Agmatine, a metabolite of L-arginine, is considered to be a novel putative neurotransmitter and has been implicated in spatial learning and memory processes. Agmatine-immunoreactivity has… (more)

▼ Agmatine, a metabolite of L-arginine, is considered to be a novel putative neurotransmitter and has been implicated in spatial learning and memory processes. Agmatine-immunoreactivity has been found in synaptic terminals of asymmetric excitatory synapses in the hippocampal CA1 region, which suggests that agmatine may be co-localized with glutamate, the primary excitatory neurotransmitter of hippocampal pyramidal cells. The first aim of the current project was to investigate if agmatine is co-localized with glutamate in the hippocampal pyramidal cells and within synaptic terminals at CA1 synapses, using immunofluorescence confocal microscopy and post-embedding electron microscopy-immunogold cytochemistry, respectively. Double immunofluorescence labelling indicated that agmatine and glutamate are co-localized in the majority of CA1-CA3 pyramidal cell bodies. Immunogold double labelling demonstrated that agmatine is also co-localized with glutamate in synaptic terminals in the CA1 stratum radiatum (SR) region. In the CA1 region of young male Sprague-Dawley rats, 97% of all agmatinergic profiles contained glutamate, and 92% of all glutamatergic profiles also contained agmatine (n = 6; 300 terminals). Having established co-localization of agmatine with glutamate within CA1 SR terminals, the second aim of the project was to investigate changes in co-localized agmatine and glutamate levels following 4 days Morris water maze training. The water maze trained rats (n = 3) showed significant increases in both agmatine and glutamate levels in the CA1 SR terminals (150 terminals; 78% increase in agmatine, p<0.01; ~41% increase in glutamate, p<0.05), compared to swim only control rats (n = 3; 150 terminals). The finding that water maze training induced increases in both agmatine and glutamate levels in the CA1 terminals, suggests that agmatine may play a role with glutamate in learning and memory processes. The final aim of the study was to examine possible spatial learning-induced structural changes at the postsynaptic site. The average thickness of the postsynaptic density at CA1 SR synapses (n = 240) was analysed. The water maze trained rats exhibited a 30% increase in their average postsynaptic density thickness (p < 0.001) compared to control rats. This suggests that there are alterations in the molecular components in the postsynaptic density following water maze training, which could lead to functional modifications of the postsynaptic neuron. Further studies are required to elucidate the molecular mechanisms by which agmatine may influence learning and memory processes, and to explore the functional significance of spatial learning induced increases in agmatine and glutamate levels and PSD thickness at CA1 SR synapses. Advisors/Committee Members: Leitch, Beulah (advisor).

Subjects/Keywords: Agmatine; Learning; Hippocampus

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APA (6^th Edition):

Seo, S. (2011). Spatial Learning-Induced Changes at Agmatinergic and Glutamatergic Synapses in the Hippocampal CA1 Region . (Masters Thesis). University of Otago. Retrieved from http://hdl.handle.net/10523/1824

Chicago Manual of Style (16^th Edition):

Seo, Steve. “Spatial Learning-Induced Changes at Agmatinergic and Glutamatergic Synapses in the Hippocampal CA1 Region .” 2011. Masters Thesis, University of Otago. Accessed February 26, 2021. http://hdl.handle.net/10523/1824.

MLA Handbook (7^th Edition):

Seo, Steve. “Spatial Learning-Induced Changes at Agmatinergic and Glutamatergic Synapses in the Hippocampal CA1 Region .” 2011. Web. 26 Feb 2021.

Vancouver:

Seo S. Spatial Learning-Induced Changes at Agmatinergic and Glutamatergic Synapses in the Hippocampal CA1 Region . [Internet] [Masters thesis]. University of Otago; 2011. [cited 2021 Feb 26]. Available from: http://hdl.handle.net/10523/1824.

Council of Science Editors:

Seo S. Spatial Learning-Induced Changes at Agmatinergic and Glutamatergic Synapses in the Hippocampal CA1 Region . [Masters Thesis]. University of Otago; 2011. Available from: http://hdl.handle.net/10523/1824

University of Victoria

11. Simpson, Jessica M. Altered Adult Hippocampal Structural and Functional Plasticity in the YAC128 Transgenic Mouse Model of Huntington Disease.

Degree: Dept. of Biology, 2013, University of Victoria

URL: http://hdl.handle.net/1828/4978

► Alterations in both structural and synaptic plasticity in the adult brain have been implicated in impaired learning and memory. In the present study, we investigated… (more)

Subjects/Keywords: Huntington's chorea; Hippocampus

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APA (6^th Edition):

Simpson, J. M. (2013). Altered Adult Hippocampal Structural and Functional Plasticity in the YAC128 Transgenic Mouse Model of Huntington Disease. (Masters Thesis). University of Victoria. Retrieved from http://hdl.handle.net/1828/4978

Chicago Manual of Style (16^th Edition):

Simpson, Jessica M. “Altered Adult Hippocampal Structural and Functional Plasticity in the YAC128 Transgenic Mouse Model of Huntington Disease.” 2013. Masters Thesis, University of Victoria. Accessed February 26, 2021. http://hdl.handle.net/1828/4978.

MLA Handbook (7^th Edition):

Simpson, Jessica M. “Altered Adult Hippocampal Structural and Functional Plasticity in the YAC128 Transgenic Mouse Model of Huntington Disease.” 2013. Web. 26 Feb 2021.

Vancouver:

Simpson JM. Altered Adult Hippocampal Structural and Functional Plasticity in the YAC128 Transgenic Mouse Model of Huntington Disease. [Internet] [Masters thesis]. University of Victoria; 2013. [cited 2021 Feb 26]. Available from: http://hdl.handle.net/1828/4978.

Council of Science Editors:

Simpson JM. Altered Adult Hippocampal Structural and Functional Plasticity in the YAC128 Transgenic Mouse Model of Huntington Disease. [Masters Thesis]. University of Victoria; 2013. Available from: http://hdl.handle.net/1828/4978

University of Illinois – Urbana-Champaign

12. Chiu, Judy Yi-Chieh. Sensitivity of relational memory representations to the factors of repetition, emotion, and context information.

Degree: PhD, Psychology, 2017, University of Illinois – Urbana-Champaign

URL: http://hdl.handle.net/2142/99192

► Episodic memory is the human cognitive faculty that enables humans to have a record of everyday events. Relational processing and representations are widely accepted to… (more)

▼ Episodic memory is the human cognitive faculty that enables humans to have a record of everyday events. Relational processing and representations are widely accepted to be the crucial underlying mechanism, implemented in the hippocampus, that support normal episodic memory function. As such, to better understand relational memory is to gain a more complete understanding of episodic memory function. One facet of hippocampal-dependent memory under intense investigation is its interaction with other factors concomitant with episodic events. The motivation behind examining these interacting factors are three-fold: (1) to gain insight into whether, and how, such factors may be incorporated into episodic memory, (2) to shed light on the underlying organization of the episodic memory representations, and (3) to observe the ultimate consequence they have on memory performance. In this dissertation, we explore 3 factors most commonly present in episodic experiences –namely, repetition, negative emotion, and context, and the sensitivity of relational memory representations to these factors. The first experiment examined relational memory sensitivity to repetition-induced changes in memory strength and its neural substrates as indexed by fMRI. The central objectives were to investigate whether variations in relational information strength is incorporated and represented in the hippocampus, and whether this response could be dissociated from changes in non-relational memory indexed by a separable memory region. Results from this experiment yielded evidence for both objectives and additionally provided support for the view that episodic memory may be represented in separable streams of information, such as item versus context, with dissociable neural substrates. The second study examined the sensitivity of relational processing to the factor of negative emotion. While attention allocation is widely cited as the mechanism for the impairing or enhancing effects of negative emotion, we tested a novel hypothesis that negative emotion may specifically impair relational processing and its underlying memory organization. Eye-movement monitoring was employed as means to provide insight on attention allocation biases by emotion, and to provide a well-established, implicit measure of relational memory performance. Results showed that, under conditions of equal overt memory accuracy, response timing and visual sampling differed between negative and neutral conditions and thus provide support that negative emotion may cause relational memories to be organized or represented differently from those without negative valence. The third study asked the question of what information properties underlie the often- invoked construct of “context” information that is an integral part of all episodic memory representations. A novel hypothesis was tested –that stability of relational information imparts context-like properties in helping organize memory representations of events, subserved by relational processing. Experiment found evidence in support… Advisors/Committee Members: Cohen, Neal J (advisor), Cohen, Neal J (Committee Chair), Gonsalves, Brian D (committee member), Dolcos, Florin (committee member), Heller, Wendy (committee member), Sahakyan, Lili (committee member).

Subjects/Keywords: Relational memory; Hippocampus

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Chiu, J. Y. (2017). Sensitivity of relational memory representations to the factors of repetition, emotion, and context information. (Doctoral Dissertation). University of Illinois – Urbana-Champaign. Retrieved from http://hdl.handle.net/2142/99192

Chicago Manual of Style (16^th Edition):

Chiu, Judy Yi-Chieh. “Sensitivity of relational memory representations to the factors of repetition, emotion, and context information.” 2017. Doctoral Dissertation, University of Illinois – Urbana-Champaign. Accessed February 26, 2021. http://hdl.handle.net/2142/99192.

MLA Handbook (7^th Edition):

Chiu, Judy Yi-Chieh. “Sensitivity of relational memory representations to the factors of repetition, emotion, and context information.” 2017. Web. 26 Feb 2021.

Vancouver:

Chiu JY. Sensitivity of relational memory representations to the factors of repetition, emotion, and context information. [Internet] [Doctoral dissertation]. University of Illinois – Urbana-Champaign; 2017. [cited 2021 Feb 26]. Available from: http://hdl.handle.net/2142/99192.

Council of Science Editors:

Chiu JY. Sensitivity of relational memory representations to the factors of repetition, emotion, and context information. [Doctoral Dissertation]. University of Illinois – Urbana-Champaign; 2017. Available from: http://hdl.handle.net/2142/99192

University of Lethbridge

13. University of Lethbridge. Faculty of Arts and Science. Patterns of hippocampal amnesia and population activity in rats: Implications for categorical and single-process models of long-term memory organization .

Degree: 2019, University of Lethbridge

URL: http://hdl.handle.net/10133/5402

► Contemporary views on the organization of long-term memory (LTM) suggest the hippocampus is involved in a unique category of LTM. Recent experiments illustrate that hippocampal… (more)

Subjects/Keywords: Hippocampus; Rat; Memory

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APA (6^th Edition):

Science, U. o. L. F. o. A. a. (2019). Patterns of hippocampal amnesia and population activity in rats: Implications for categorical and single-process models of long-term memory organization . (Thesis). University of Lethbridge. Retrieved from http://hdl.handle.net/10133/5402

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Science, University of Lethbridge. Faculty of Arts and. “Patterns of hippocampal amnesia and population activity in rats: Implications for categorical and single-process models of long-term memory organization .” 2019. Thesis, University of Lethbridge. Accessed February 26, 2021. http://hdl.handle.net/10133/5402.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Science, University of Lethbridge. Faculty of Arts and. “Patterns of hippocampal amnesia and population activity in rats: Implications for categorical and single-process models of long-term memory organization .” 2019. Web. 26 Feb 2021.

Vancouver:

Science UoLFoAa. Patterns of hippocampal amnesia and population activity in rats: Implications for categorical and single-process models of long-term memory organization . [Internet] [Thesis]. University of Lethbridge; 2019. [cited 2021 Feb 26]. Available from: http://hdl.handle.net/10133/5402.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Science UoLFoAa. Patterns of hippocampal amnesia and population activity in rats: Implications for categorical and single-process models of long-term memory organization . [Thesis]. University of Lethbridge; 2019. Available from: http://hdl.handle.net/10133/5402

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Rutgers University

14. Yarotsky, John J. The association of p75NTR and co-receptors in hippocampal neurons and astrocytes.

Degree: PhD, Biology, 2015, Rutgers University

URL: https://rucore.libraries.rutgers.edu/rutgers-lib/47720/

►

Neurons in the hippocampus are dependent on neurotrophins for survival. Upon injury, proneurotrophins cause hippocampal neurons to undergo apoptosis. These two distinct effects can be… (more)

Subjects/Keywords: Hippocampus (Brain); Astrocytes

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APA (6^th Edition):

Yarotsky, J. J. (2015). The association of p75NTR and co-receptors in hippocampal neurons and astrocytes. (Doctoral Dissertation). Rutgers University. Retrieved from https://rucore.libraries.rutgers.edu/rutgers-lib/47720/

Chicago Manual of Style (16^th Edition):

Yarotsky, John J. “The association of p75NTR and co-receptors in hippocampal neurons and astrocytes.” 2015. Doctoral Dissertation, Rutgers University. Accessed February 26, 2021. https://rucore.libraries.rutgers.edu/rutgers-lib/47720/.

MLA Handbook (7^th Edition):

Yarotsky, John J. “The association of p75NTR and co-receptors in hippocampal neurons and astrocytes.” 2015. Web. 26 Feb 2021.

Vancouver:

Yarotsky JJ. The association of p75NTR and co-receptors in hippocampal neurons and astrocytes. [Internet] [Doctoral dissertation]. Rutgers University; 2015. [cited 2021 Feb 26]. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/47720/.

Council of Science Editors:

Yarotsky JJ. The association of p75NTR and co-receptors in hippocampal neurons and astrocytes. [Doctoral Dissertation]. Rutgers University; 2015. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/47720/

University of Pennsylvania

15. Wang, Melissa Eveline. The Role of the Hippocampus in Representations of Emotional Memory.

Degree: 2013, University of Pennsylvania

URL: https://repository.upenn.edu/edissertations/940

► Although the hippocampus has long been implicated in contextual fear learning, the exact function of this brain structure is unclear. It is generally thought to… (more)

▼ Although the hippocampus has long been implicated in contextual fear learning, the exact function of this brain structure is unclear. It is generally thought to encode a spatial context with which a fear memory can be associated, but how it may accomplish this and whether it plays a role in emotional memory is largely unknown. It is also unclear whether the hippocampus acts as a single unitary structure, or whether the dorsal and ventral poles, which exhibit differential connectivity to other brain regions, function independently. This dissertation examines the involvement of the hippocampus in emotional learning. A contextual fear conditioning paradigm using a predator odor as an ethologically relevant fearful stimulus was developed and lesions and immunohistochemistry were used to examine differential involvement of the dorsal and ventral hippocampus in response to fear learning. Long-term physiological recordings of dorsal place cells were then conducted to determine the effects of fear conditioning and also fear extinction on contextual representations in the hippocampus. Additionally, cells in the ventral hippocampus were assessed for responses to visuospatial manipulations and changing odor cues of varying emotional valence. It was found that the dorsal and ventral hippocampal regions are both independently required for contextual fear conditioning, and neurons in each region are differentially activated in response to fear learning. Furthermore, place cells in the dorsal hippocampus remapped in response to fear conditioning and stabilized those new fields in the long term. Extinction training caused many place cells to remap once again, suggesting that the dorsal hippocampus encodes varying representations of `fearful' and `safe' contexts. Finally, cells in the ventral hippocampus exhibited stronger responses to anxiogenic contextual cues compared to dorsal cells. In conclusion, these data suggest that the hippocampus is involved in emotional learning and that its function may vary along its longitudinal axis.

Subjects/Keywords: context; dorsal hippocampus; emotion; fear conditioning; hippocampus; ventral hippocampus; Neuroscience and Neurobiology

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APA (6^th Edition):

Wang, M. E. (2013). The Role of the Hippocampus in Representations of Emotional Memory. (Thesis). University of Pennsylvania. Retrieved from https://repository.upenn.edu/edissertations/940

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Wang, Melissa Eveline. “The Role of the Hippocampus in Representations of Emotional Memory.” 2013. Thesis, University of Pennsylvania. Accessed February 26, 2021. https://repository.upenn.edu/edissertations/940.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Wang, Melissa Eveline. “The Role of the Hippocampus in Representations of Emotional Memory.” 2013. Web. 26 Feb 2021.

Vancouver:

Wang ME. The Role of the Hippocampus in Representations of Emotional Memory. [Internet] [Thesis]. University of Pennsylvania; 2013. [cited 2021 Feb 26]. Available from: https://repository.upenn.edu/edissertations/940.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Wang ME. The Role of the Hippocampus in Representations of Emotional Memory. [Thesis]. University of Pennsylvania; 2013. Available from: https://repository.upenn.edu/edissertations/940

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Ruhr Universität Bochum

16. Abdulazim, Amr Nabil. Funktionelle Untersuchungen zur Rolle von Pannexin 1 in der hippocampalen Neuroplastizität.

Degree: 2014, Ruhr Universität Bochum

URL: http://nbn-resolving.de/urn/resolver.pl?urn=urn:nbn:de:hbz:294-42429

► Pannexin 1 (Panx1) sind integrale Membranproteine, die Membrankanäle mit sehr hoher Leitfähigkeit (550 pS) bilden. Neben der Beteiligung an pathophysiologischen Prozessen, wie Inflammation oder Ischämie,… (more)

Subjects/Keywords: Gedächtnis; Hippocampus; Langzeitpotenzierung; Lernen; Synapse

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APA (6^th Edition):

Abdulazim, A. N. (2014). Funktionelle Untersuchungen zur Rolle von Pannexin 1 in der hippocampalen Neuroplastizität. (Thesis). Ruhr Universität Bochum. Retrieved from http://nbn-resolving.de/urn/resolver.pl?urn=urn:nbn:de:hbz:294-42429

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Abdulazim, Amr Nabil. “Funktionelle Untersuchungen zur Rolle von Pannexin 1 in der hippocampalen Neuroplastizität.” 2014. Thesis, Ruhr Universität Bochum. Accessed February 26, 2021. http://nbn-resolving.de/urn/resolver.pl?urn=urn:nbn:de:hbz:294-42429.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Abdulazim, Amr Nabil. “Funktionelle Untersuchungen zur Rolle von Pannexin 1 in der hippocampalen Neuroplastizität.” 2014. Web. 26 Feb 2021.

Vancouver:

Abdulazim AN. Funktionelle Untersuchungen zur Rolle von Pannexin 1 in der hippocampalen Neuroplastizität. [Internet] [Thesis]. Ruhr Universität Bochum; 2014. [cited 2021 Feb 26]. Available from: http://nbn-resolving.de/urn/resolver.pl?urn=urn:nbn:de:hbz:294-42429.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Abdulazim AN. Funktionelle Untersuchungen zur Rolle von Pannexin 1 in der hippocampalen Neuroplastizität. [Thesis]. Ruhr Universität Bochum; 2014. Available from: http://nbn-resolving.de/urn/resolver.pl?urn=urn:nbn:de:hbz:294-42429

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Ruhr Universität Bochum

17. Popkirov, Stoyan Georgiev. Synaptische Plastizität im Hippocampus : die Rolle des metabotropen Glutamatrezeptors Subtyp 5 bei der Langzeit- Depression an der CA1-Synapse und beim hippokampalen Lernen.

Degree: 2014, Ruhr Universität Bochum

URL: http://nbn-resolving.de/urn/resolver.pl?urn=urn:nbn:de:hbz:294-42607

► Am Tiermodell der sich frei verhaltenden Ratte konnten wir mittels niederfrequenter Stimulation der Schaffer- Kollateralen Kurzzeit- und Langzeit-Depression der Potentialantwort in der Hippocampus-Region CA1 induzieren.… (more)

Subjects/Keywords: Neurophysiologie; Lernen; Gedächtnis; Hippocampus; Depression

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APA (6^th Edition):

Popkirov, S. G. (2014). Synaptische Plastizität im Hippocampus : die Rolle des metabotropen Glutamatrezeptors Subtyp 5 bei der Langzeit- Depression an der CA1-Synapse und beim hippokampalen Lernen. (Thesis). Ruhr Universität Bochum. Retrieved from http://nbn-resolving.de/urn/resolver.pl?urn=urn:nbn:de:hbz:294-42607

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Popkirov, Stoyan Georgiev. “Synaptische Plastizität im Hippocampus : die Rolle des metabotropen Glutamatrezeptors Subtyp 5 bei der Langzeit- Depression an der CA1-Synapse und beim hippokampalen Lernen.” 2014. Thesis, Ruhr Universität Bochum. Accessed February 26, 2021. http://nbn-resolving.de/urn/resolver.pl?urn=urn:nbn:de:hbz:294-42607.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Popkirov, Stoyan Georgiev. “Synaptische Plastizität im Hippocampus : die Rolle des metabotropen Glutamatrezeptors Subtyp 5 bei der Langzeit- Depression an der CA1-Synapse und beim hippokampalen Lernen.” 2014. Web. 26 Feb 2021.

Vancouver:

Popkirov SG. Synaptische Plastizität im Hippocampus : die Rolle des metabotropen Glutamatrezeptors Subtyp 5 bei der Langzeit- Depression an der CA1-Synapse und beim hippokampalen Lernen. [Internet] [Thesis]. Ruhr Universität Bochum; 2014. [cited 2021 Feb 26]. Available from: http://nbn-resolving.de/urn/resolver.pl?urn=urn:nbn:de:hbz:294-42607.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Popkirov SG. Synaptische Plastizität im Hippocampus : die Rolle des metabotropen Glutamatrezeptors Subtyp 5 bei der Langzeit- Depression an der CA1-Synapse und beim hippokampalen Lernen. [Thesis]. Ruhr Universität Bochum; 2014. Available from: http://nbn-resolving.de/urn/resolver.pl?urn=urn:nbn:de:hbz:294-42607

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Ruhr Universität Bochum

18. Hagena, Hardy. Examination of the role of long-term synaptic plasticity at hippocampal CA3 synapses in spatial memory.

Degree: 2009, Ruhr Universität Bochum

URL: http://nbn-resolving.de/urn/resolver.pl?urn=urn:nbn:de:hbz:294-26858

► Wir haben untersucht, ob die Frequenz Faszilitierung, eine charakteristische Eigenschaft der Moosfaser-CA3 Synapse, nachhaltige funktionelle Konsequenzen für die Verarbeitung von Informationen hat. Ein Teil dieser… (more)

Subjects/Keywords: Hippocampus; Plastizität; Lernen; Adenosin; Proteinsynthese

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APA (6^th Edition):

Hagena, H. (2009). Examination of the role of long-term synaptic plasticity at hippocampal CA3 synapses in spatial memory. (Thesis). Ruhr Universität Bochum. Retrieved from http://nbn-resolving.de/urn/resolver.pl?urn=urn:nbn:de:hbz:294-26858

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Hagena, Hardy. “Examination of the role of long-term synaptic plasticity at hippocampal CA3 synapses in spatial memory.” 2009. Thesis, Ruhr Universität Bochum. Accessed February 26, 2021. http://nbn-resolving.de/urn/resolver.pl?urn=urn:nbn:de:hbz:294-26858.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Hagena, Hardy. “Examination of the role of long-term synaptic plasticity at hippocampal CA3 synapses in spatial memory.” 2009. Web. 26 Feb 2021.

Vancouver:

Hagena H. Examination of the role of long-term synaptic plasticity at hippocampal CA3 synapses in spatial memory. [Internet] [Thesis]. Ruhr Universität Bochum; 2009. [cited 2021 Feb 26]. Available from: http://nbn-resolving.de/urn/resolver.pl?urn=urn:nbn:de:hbz:294-26858.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Hagena H. Examination of the role of long-term synaptic plasticity at hippocampal CA3 synapses in spatial memory. [Thesis]. Ruhr Universität Bochum; 2009. Available from: http://nbn-resolving.de/urn/resolver.pl?urn=urn:nbn:de:hbz:294-26858

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Ruhr Universität Bochum

19. Brühl, Hannah. From insulin resistance to type 2 diabetes mellitus : the relationship of metabolic dysregulation, HPA axis, and retinal vessels to cognition and the brain.

Degree: 2009, Ruhr Universität Bochum

URL: http://nbn-resolving.de/urn/resolver.pl?urn=urn:nbn:de:hbz:294-27533

► In dieser Dissertationsschrift sollten die Auswirkungen von Typ 2 Diabetes Mellitus (T2DM) und zugrundeliegender Insulinresistenz (IR) auf Kognition und Gehirnstruktur ermittelt werden. Dabei wurden Faktoren… (more)

Subjects/Keywords: Altersdiabetes; Fettsucht; Stress; Hippocampus; Gedächtnis

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APA (6^th Edition):

Brühl, H. (2009). From insulin resistance to type 2 diabetes mellitus : the relationship of metabolic dysregulation, HPA axis, and retinal vessels to cognition and the brain. (Thesis). Ruhr Universität Bochum. Retrieved from http://nbn-resolving.de/urn/resolver.pl?urn=urn:nbn:de:hbz:294-27533

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Brühl, Hannah. “From insulin resistance to type 2 diabetes mellitus : the relationship of metabolic dysregulation, HPA axis, and retinal vessels to cognition and the brain.” 2009. Thesis, Ruhr Universität Bochum. Accessed February 26, 2021. http://nbn-resolving.de/urn/resolver.pl?urn=urn:nbn:de:hbz:294-27533.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Brühl, Hannah. “From insulin resistance to type 2 diabetes mellitus : the relationship of metabolic dysregulation, HPA axis, and retinal vessels to cognition and the brain.” 2009. Web. 26 Feb 2021.

Vancouver:

Brühl H. From insulin resistance to type 2 diabetes mellitus : the relationship of metabolic dysregulation, HPA axis, and retinal vessels to cognition and the brain. [Internet] [Thesis]. Ruhr Universität Bochum; 2009. [cited 2021 Feb 26]. Available from: http://nbn-resolving.de/urn/resolver.pl?urn=urn:nbn:de:hbz:294-27533.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Brühl H. From insulin resistance to type 2 diabetes mellitus : the relationship of metabolic dysregulation, HPA axis, and retinal vessels to cognition and the brain. [Thesis]. Ruhr Universität Bochum; 2009. Available from: http://nbn-resolving.de/urn/resolver.pl?urn=urn:nbn:de:hbz:294-27533

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Ruhr Universität Bochum

20. Kenney, Jana. Investigation of synaptic plasticity expressed along the dorsoventral axis of the hippocampus in vivo.

Degree: 2012, Ruhr Universität Bochum

URL: http://nbn-resolving.de/urn/resolver.pl?urn=urn:nbn:de:hbz:294-39084

► Der Hippocampus scheint funktionell entlang seiner dorsoventralen Achse unterschiedlich zu sein. Im Gegensatz zu den vorhandenen Daten über synaptischen Plastizität im dorsalen Hippocampus, ist wenig… (more)

Subjects/Keywords: Lernen; Gedächtnis; Gehirn; Synapse; Hippocampus

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APA (6^th Edition):

Kenney, J. (2012). Investigation of synaptic plasticity expressed along the dorsoventral axis of the hippocampus in vivo. (Thesis). Ruhr Universität Bochum. Retrieved from http://nbn-resolving.de/urn/resolver.pl?urn=urn:nbn:de:hbz:294-39084

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Kenney, Jana. “Investigation of synaptic plasticity expressed along the dorsoventral axis of the hippocampus in vivo.” 2012. Thesis, Ruhr Universität Bochum. Accessed February 26, 2021. http://nbn-resolving.de/urn/resolver.pl?urn=urn:nbn:de:hbz:294-39084.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Kenney, Jana. “Investigation of synaptic plasticity expressed along the dorsoventral axis of the hippocampus in vivo.” 2012. Web. 26 Feb 2021.

Vancouver:

Kenney J. Investigation of synaptic plasticity expressed along the dorsoventral axis of the hippocampus in vivo. [Internet] [Thesis]. Ruhr Universität Bochum; 2012. [cited 2021 Feb 26]. Available from: http://nbn-resolving.de/urn/resolver.pl?urn=urn:nbn:de:hbz:294-39084.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Kenney J. Investigation of synaptic plasticity expressed along the dorsoventral axis of the hippocampus in vivo. [Thesis]. Ruhr Universität Bochum; 2012. Available from: http://nbn-resolving.de/urn/resolver.pl?urn=urn:nbn:de:hbz:294-39084

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Otago

21. Smith, Paul. Vestibular Contributions to Spatial Memory and Hippocampal Function.

Degree: 2014, University of Otago

URL: http://hdl.handle.net/10523/4817

► In addition to the deficits in the vestibulo-ocular and vestibulo-spinal reflexes that occur following vestibular dysfunction, vestibular loss may also cause cognitive disorders, especially spatial… (more)

Subjects/Keywords: vestibular; hippocampus; spatial; memory

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APA (6^th Edition):

Smith, P. (2014). Vestibular Contributions to Spatial Memory and Hippocampal Function. (Doctoral Dissertation). University of Otago. Retrieved from http://hdl.handle.net/10523/4817

Chicago Manual of Style (16^th Edition):

Smith, Paul. “Vestibular Contributions to Spatial Memory and Hippocampal Function. ” 2014. Doctoral Dissertation, University of Otago. Accessed February 26, 2021. http://hdl.handle.net/10523/4817.

MLA Handbook (7^th Edition):

Smith, Paul. “Vestibular Contributions to Spatial Memory and Hippocampal Function. ” 2014. Web. 26 Feb 2021.

Vancouver:

Smith P. Vestibular Contributions to Spatial Memory and Hippocampal Function. [Internet] [Doctoral dissertation]. University of Otago; 2014. [cited 2021 Feb 26]. Available from: http://hdl.handle.net/10523/4817.

Council of Science Editors:

Smith P. Vestibular Contributions to Spatial Memory and Hippocampal Function. [Doctoral Dissertation]. University of Otago; 2014. Available from: http://hdl.handle.net/10523/4817

Dalhousie University

22. McClelland, Christine R. Cux2 regulates neurogenesis in the postnatal mouse hippocampus.

Degree: MS, Department of Anatomy & Neurobiolgy with Neuroscience, 2012, Dalhousie University

URL: http://hdl.handle.net/10222/15237

► Although once thought to be incapable of regeneration, the adult mammalian brain generates new neurons in two regions: the SVZ of the lateral ventricle and… (more)

Subjects/Keywords: Hippocampus; Cux2; adult neurogenesis

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APA (6^th Edition):

McClelland, C. R. (2012). Cux2 regulates neurogenesis in the postnatal mouse hippocampus. (Masters Thesis). Dalhousie University. Retrieved from http://hdl.handle.net/10222/15237

Chicago Manual of Style (16^th Edition):

McClelland, Christine R. “Cux2 regulates neurogenesis in the postnatal mouse hippocampus.” 2012. Masters Thesis, Dalhousie University. Accessed February 26, 2021. http://hdl.handle.net/10222/15237.

MLA Handbook (7^th Edition):

McClelland, Christine R. “Cux2 regulates neurogenesis in the postnatal mouse hippocampus.” 2012. Web. 26 Feb 2021.

Vancouver:

McClelland CR. Cux2 regulates neurogenesis in the postnatal mouse hippocampus. [Internet] [Masters thesis]. Dalhousie University; 2012. [cited 2021 Feb 26]. Available from: http://hdl.handle.net/10222/15237.

Council of Science Editors:

McClelland CR. Cux2 regulates neurogenesis in the postnatal mouse hippocampus. [Masters Thesis]. Dalhousie University; 2012. Available from: http://hdl.handle.net/10222/15237

University of Ottawa

23. Soares, Cary. Mechanisms of Synaptic Homeostasis and their Influence on Hebbian Plasticity at CA1 Hippocampal Synapses .

Degree: 2016, University of Ottawa

URL: http://hdl.handle.net/10393/35508

► Information is transferred between neurons in the brain via electrochemical transmission at specialized cell-cell junctions called synapses. These structures are far from being static, but… (more)

▼ Information is transferred between neurons in the brain via electrochemical transmission at specialized cell-cell junctions called synapses. These structures are far from being static, but rather are influenced by plasticity mechanisms that alter features of synaptic transmission as means to build routes of information flow in the brain. Hebbian forms of synaptic plasticity – long-term potentiation and long-term depression – have been well studied and are considered to be the cellular basis of learning and memory, although their positive feedback nature is prone to instability. Neurons are also endowed with homeostatic mechanisms of synaptic plasticity that act to stabilize neural network functions by globally tuning synaptic drive. Precisely how neurons orchestrate this adaptive homeostatic response and how it influences Hebbian forms of synaptic plasticity, however, remains only partially understood. Using a combination of whole-cell electrophysiology, two-photon imaging and glutamate uncaging in organotypic hippocampal slices, I have expanded upon the known repertoire of homeostatic mechanisms that increase excitatory synaptic drive when CA1 hippocampal neurons experience a prolonged period of diminished activity. I found that the subunit composition of AMPA and NMDA receptors, the two major glutamate receptor subtypes at excitatory synapses, are altered which, in addition to increasing synaptic strength, are predicted to change the signaling and integrative properties of synaptic transmission. Moreover, I found that the amount of glutamate released from presynaptic terminals during evoked-transmission is enhanced and that this mechanism might, in part, underlie the uniform cell-wide homeostatic increase in synaptic strengths. Lastly, I found that homeostatic strengthening of synaptic transmission reduced the potential for CA1 synapses to exhibit long-term potentiation, and that this was caused by altered presynaptic release dynamics that impeded plasticity induction. Together, this work highlights several mechanistic strategies employed by neurons to increase excitatory synaptic drive during periods of activity deprivation which, in addition to balancing cellular excitability, alters the metaplastic state of synapses.

Subjects/Keywords: Synapses; Plasticity; Homeostasis; Hippocampus

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APA (6^th Edition):

Soares, C. (2016). Mechanisms of Synaptic Homeostasis and their Influence on Hebbian Plasticity at CA1 Hippocampal Synapses . (Thesis). University of Ottawa. Retrieved from http://hdl.handle.net/10393/35508

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Soares, Cary. “Mechanisms of Synaptic Homeostasis and their Influence on Hebbian Plasticity at CA1 Hippocampal Synapses .” 2016. Thesis, University of Ottawa. Accessed February 26, 2021. http://hdl.handle.net/10393/35508.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Soares, Cary. “Mechanisms of Synaptic Homeostasis and their Influence on Hebbian Plasticity at CA1 Hippocampal Synapses .” 2016. Web. 26 Feb 2021.

Vancouver:

Soares C. Mechanisms of Synaptic Homeostasis and their Influence on Hebbian Plasticity at CA1 Hippocampal Synapses . [Internet] [Thesis]. University of Ottawa; 2016. [cited 2021 Feb 26]. Available from: http://hdl.handle.net/10393/35508.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Soares C. Mechanisms of Synaptic Homeostasis and their Influence on Hebbian Plasticity at CA1 Hippocampal Synapses . [Thesis]. University of Ottawa; 2016. Available from: http://hdl.handle.net/10393/35508

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Alberta

24. Sharma, Arjun V. Neurosilence: intracerebral applications of protein synthesis inhibitors eliminate neural activity.

Degree: MS, Department of Psychology, 2010, University of Alberta

URL: https://era.library.ualberta.ca/files/47429b262

► The acquisition of a behavioural response (learning) and the later retrieval of this response (memory) are separated by an endogenous biological process which consolidates the… (more)

Subjects/Keywords: memory; cycloheximide; EEG; anisomycin; hippocampus

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APA (6^th Edition):

Sharma, A. V. (2010). Neurosilence: intracerebral applications of protein synthesis inhibitors eliminate neural activity. (Masters Thesis). University of Alberta. Retrieved from https://era.library.ualberta.ca/files/47429b262

Chicago Manual of Style (16^th Edition):

Sharma, Arjun V. “Neurosilence: intracerebral applications of protein synthesis inhibitors eliminate neural activity.” 2010. Masters Thesis, University of Alberta. Accessed February 26, 2021. https://era.library.ualberta.ca/files/47429b262.

MLA Handbook (7^th Edition):

Sharma, Arjun V. “Neurosilence: intracerebral applications of protein synthesis inhibitors eliminate neural activity.” 2010. Web. 26 Feb 2021.

Vancouver:

Sharma AV. Neurosilence: intracerebral applications of protein synthesis inhibitors eliminate neural activity. [Internet] [Masters thesis]. University of Alberta; 2010. [cited 2021 Feb 26]. Available from: https://era.library.ualberta.ca/files/47429b262.

Council of Science Editors:

Sharma AV. Neurosilence: intracerebral applications of protein synthesis inhibitors eliminate neural activity. [Masters Thesis]. University of Alberta; 2010. Available from: https://era.library.ualberta.ca/files/47429b262

McMaster University

25. Finnegan, Rory. Computational Modelling of Adult Hippocampal Neurogenesis.

Degree: MSc, 2016, McMaster University

URL: http://hdl.handle.net/11375/20666

►

The hippocampus has been the focus of memory research for decades. While the functional role of this structure is not fully understood, it is widely… (more)

▼

The hippocampus has been the focus of memory research for decades. While the functional role of this structure is not fully understood, it is widely recognized as being vital for rapid yet accurate encoding and retrieval of associative memories. Since the discovery of adult hippocampal neurogenesis (AHN) in the dentate gyrus (DG) by Altman and Das in the 1960s, many theories and models have been formulated to explain the functional role it plays in learning and memory. These models postulate different ways in which new neurons are introduced into the DG and their functional importance for learning and memory. Few, if any, previous models have incorporated the unique properties of young adult-born dentate granule cells (DGCs) and their developmental trajectory. In this thesis, we propose a novel computational model of the DG that incorporates the developmental trajectory of these DGCs, including changes in synaptic plasticity, connectivity, excitability and lateral inhibition, using a modified version of the restricted boltzmann machine (RBM). Our results show superior performance on memory reconstruction tasks for both recent and distally learned items, when the unique characteristics of young DGCs are taken into account. The unique properties of the young neurons contribute to reducing retroactive and proactive interference, at both short and long time scales, despite the reduction in pattern separation due to their hyperexcitability. Our replacement model is subsequently extended to support learning dependent regulation of neurogenesis and apoptosis, using a convergence based approach to network growing and pruning. This hybrid additive and replacement model provides a more realistic and flexible approach to investigating the role of neurogenesis regulation in learning and memory. Finally, we incorporate the dentate gyrus model into a full hippocampal circuit to assess cued recall performance. Once again, our neurogenesis model shows decreased proactive and retroactive interference.

Thesis

Master of Science (MSc)

Advisors/Committee Members: Becker, Suzanna, Neuroscience.

Subjects/Keywords: Hippocampus; Neurogenesis; Modelling; Neural Networks

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APA (6^th Edition):

Finnegan, R. (2016). Computational Modelling of Adult Hippocampal Neurogenesis. (Masters Thesis). McMaster University. Retrieved from http://hdl.handle.net/11375/20666

Chicago Manual of Style (16^th Edition):

Finnegan, Rory. “Computational Modelling of Adult Hippocampal Neurogenesis.” 2016. Masters Thesis, McMaster University. Accessed February 26, 2021. http://hdl.handle.net/11375/20666.

MLA Handbook (7^th Edition):

Finnegan, Rory. “Computational Modelling of Adult Hippocampal Neurogenesis.” 2016. Web. 26 Feb 2021.

Vancouver:

Finnegan R. Computational Modelling of Adult Hippocampal Neurogenesis. [Internet] [Masters thesis]. McMaster University; 2016. [cited 2021 Feb 26]. Available from: http://hdl.handle.net/11375/20666.

Council of Science Editors:

Finnegan R. Computational Modelling of Adult Hippocampal Neurogenesis. [Masters Thesis]. McMaster University; 2016. Available from: http://hdl.handle.net/11375/20666

McMaster University

26. Clark, Ilana Bayley. COMBINED EXERCISE AND COGNITIVE TRAINING ENHANCES HIPPOCAMPAL-DEPENDENT MEMORY.

Degree: MSc, 2015, McMaster University

URL: http://hdl.handle.net/11375/18276

►

There is an established link between exercise, neurogenesis, and memory. Most of this research has been focused on rodent models, with little known about the… (more)

▼

There is an established link between exercise, neurogenesis, and memory. Most of this research has been focused on rodent models, with little known about the effects of exercise on cognition in young adults. In rodents, exercise promotes hippocampal neurogenesis by enhancing cell proliferation in the dentate gyrus, while cognitive training promotes hippocampal neurogenesis by enhancing cell survival. Both physical exercise and cognitive training independently induce hippocampal neurogenesis in rodents, suggesting that these different forms of training may work through complimentary neurological pathways to benefit hippocampal memory in young adults. The present study examined the effects of six weeks of physical exercise and cognitive training on hippocampal-mediated memory processes in young adults to determine whether combined training yields enhanced memory benefits. Sixty-six sedentary young adults (32 females; age range 17-30 years) were randomly assigned to one of four groups: 1) Exercise training group (n=15), 2) Cognitive training group (n=16), 3) Combined exercise and cognitive training group (n=18), or 4) No-contact control group (n=17). Memory performance was assessed before and after the intervention on a putative hippocampal neurogenesis-dependent task, the Pattern Separation task. Growth factors that support neuron survival and function, brain-derived neurotrophic factor (BDNF) and insulin-like growth factor 1 (IGF-1) were measured in blood serum using enzyme-linked immunosorbent assays (ELISA). Based on the literature, the combination of exercise and cognitive training was expected to improve pattern separation performance more than the exercise or cognitive training alone, and display augmented effects for high responders to the exercise training. Additionally, if BDNF and IGF-1 were found to be involved in the mechanisms regulating the observed changes in memory, they too were expected to increase the most from the combined training and be dependent on individual changes in aerobic fitness. Critically, the combination of exercise and cognitive training led to the greatest increase in memory requiring pattern separation [t(16) = 2.91, p < 0.01] , indicating improved hippocampal-mediated memory function. BDNF and IGF-1 were not associated with this change in memory performance but were associated with the individual’s response to the exercise training, such that high responders to exercise had greater BDNF [F(1, 29) = 7.81, p < 0.01] and IGF-1 [F(1, 29) = 5.09, p < 0.05] than low responders to exercise. The results suggest that exercise and cognitive training may work through synergistic mechanisms to enhance hippocampal neurogenesis and support pattern separation processing. However, BDNF and IGF-1 may not be mediating this change in memory function.

Thesis

Master of Science (MSc)

Advisors/Committee Members: Heisz, Jennifer J, Kinesiology.

Subjects/Keywords: exercise; cognitive training; memory; hippocampus

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APA (6^th Edition):

Clark, I. B. (2015). COMBINED EXERCISE AND COGNITIVE TRAINING ENHANCES HIPPOCAMPAL-DEPENDENT MEMORY. (Masters Thesis). McMaster University. Retrieved from http://hdl.handle.net/11375/18276

Chicago Manual of Style (16^th Edition):

Clark, Ilana Bayley. “COMBINED EXERCISE AND COGNITIVE TRAINING ENHANCES HIPPOCAMPAL-DEPENDENT MEMORY.” 2015. Masters Thesis, McMaster University. Accessed February 26, 2021. http://hdl.handle.net/11375/18276.

MLA Handbook (7^th Edition):

Clark, Ilana Bayley. “COMBINED EXERCISE AND COGNITIVE TRAINING ENHANCES HIPPOCAMPAL-DEPENDENT MEMORY.” 2015. Web. 26 Feb 2021.

Vancouver:

Clark IB. COMBINED EXERCISE AND COGNITIVE TRAINING ENHANCES HIPPOCAMPAL-DEPENDENT MEMORY. [Internet] [Masters thesis]. McMaster University; 2015. [cited 2021 Feb 26]. Available from: http://hdl.handle.net/11375/18276.

Council of Science Editors:

Clark IB. COMBINED EXERCISE AND COGNITIVE TRAINING ENHANCES HIPPOCAMPAL-DEPENDENT MEMORY. [Masters Thesis]. McMaster University; 2015. Available from: http://hdl.handle.net/11375/18276

Penn State University

27. Wang, Fan. Developing hippocampal delivery of AAV-NeuroD1 as a novel therapy for Alzheimer's disease.

Degree: 2016, Penn State University

URL: https://submit-etda.libraries.psu.edu/catalog/27567

► Alzheimer’s disease (AD) is the most common neurodegenerative disorder in the elderly and is the leading cause of most dementia cases. Patients with AD experience… (more)

Subjects/Keywords: Alzheimer's disease; NeuroD1; hippocampus; AAV

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APA (6^th Edition):

Wang, F. (2016). Developing hippocampal delivery of AAV-NeuroD1 as a novel therapy for Alzheimer's disease. (Thesis). Penn State University. Retrieved from https://submit-etda.libraries.psu.edu/catalog/27567

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Wang, Fan. “Developing hippocampal delivery of AAV-NeuroD1 as a novel therapy for Alzheimer's disease.” 2016. Thesis, Penn State University. Accessed February 26, 2021. https://submit-etda.libraries.psu.edu/catalog/27567.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Wang, Fan. “Developing hippocampal delivery of AAV-NeuroD1 as a novel therapy for Alzheimer's disease.” 2016. Web. 26 Feb 2021.

Vancouver:

Wang F. Developing hippocampal delivery of AAV-NeuroD1 as a novel therapy for Alzheimer's disease. [Internet] [Thesis]. Penn State University; 2016. [cited 2021 Feb 26]. Available from: https://submit-etda.libraries.psu.edu/catalog/27567.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Wang F. Developing hippocampal delivery of AAV-NeuroD1 as a novel therapy for Alzheimer's disease. [Thesis]. Penn State University; 2016. Available from: https://submit-etda.libraries.psu.edu/catalog/27567

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Texas Southwestern Medical Center

28. Stan, Ana Despina. Astrocytic Contribution to the Glutamatergic Transmission in Schizophrenia.

Degree: 2011, University of Texas Southwestern Medical Center

URL: http://hdl.handle.net/2152.5/842

► Schizophrenia is a chronic mental disorder encompassing an array of cognitive and behavioral manifestations. Although the disease molecular pathophysiology remains essentially unknown, evidence exists for… (more)

▼ Schizophrenia is a chronic mental disorder encompassing an array of cognitive and behavioral manifestations. Although the disease molecular pathophysiology remains essentially unknown, evidence exists for abnormalities within all the main neurotransmitter systems and various cortical and subcortical brain structures, albeit with no unifying/overarching hypothesis connecting the existent knowledge. Moreover, no current animal model or biological construct reproduces the complexity of the disease with acceptable validity. In my work I have taken a multidisciplinary approach to study the live and postmortem human brains of people with schizophrenia, focusing specifically on the glutamatergic abnormalities in the hippocampus, one brain region repeatedly found to bear structural, molecular, and blood flow abnormalities in the disease. I have started with the in vivo measurement of glutamate and glutamine using magnetic resonance spectroscopy, thus getting a “high-level” sense of the glutamatergic transmission changes in the hippocampi of subjects with schizophrenia. Concretely, I have found that untreated people with schizophrenia have reduced levels of glutamate compared to their healthy counterparts, but this reduction can be partially reversed by antipsychotic medication. To allow for a more “small-scale” characterization of the glutamatergic transmission impairments, I have used postmortem brain tissue to zoom in on the glutamatergic synapse, viewed as a “tripartite synapse”. Apart from the pre- and postsynaptic neurons, the third component is represented by the astrocyte, the brain glial cell that is responsible for most of the glutamate recycling and that attunes the glutamatergic synapse to the overall energetic metabolism of the brain. I have found that glutamate recycling is impaired in schizophrenia, selectively in the dentate gyrus, one of vii the hippocampal subregions, and the specific abnormalities reside in the glutamate transporters, responsible clearing up synaptic glutamate. Advisors/Committee Members: Tamminga, Carol.

Subjects/Keywords: Schizophrenia; Hippocampus; Glutamic Acid

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APA (6^th Edition):

Stan, A. D. (2011). Astrocytic Contribution to the Glutamatergic Transmission in Schizophrenia. (Thesis). University of Texas Southwestern Medical Center. Retrieved from http://hdl.handle.net/2152.5/842

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Stan, Ana Despina. “Astrocytic Contribution to the Glutamatergic Transmission in Schizophrenia.” 2011. Thesis, University of Texas Southwestern Medical Center. Accessed February 26, 2021. http://hdl.handle.net/2152.5/842.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Stan, Ana Despina. “Astrocytic Contribution to the Glutamatergic Transmission in Schizophrenia.” 2011. Web. 26 Feb 2021.

Vancouver:

Stan AD. Astrocytic Contribution to the Glutamatergic Transmission in Schizophrenia. [Internet] [Thesis]. University of Texas Southwestern Medical Center; 2011. [cited 2021 Feb 26]. Available from: http://hdl.handle.net/2152.5/842.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Stan AD. Astrocytic Contribution to the Glutamatergic Transmission in Schizophrenia. [Thesis]. University of Texas Southwestern Medical Center; 2011. Available from: http://hdl.handle.net/2152.5/842

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Newcastle

29. Walsh, Bernard Anthony. The relationship between early Alzheimer’s Disease, Apolipoprotein E genotyping & Hippocampal MRI Volumes.

Degree: MPhil, 2014, University of Newcastle

URL: http://hdl.handle.net/1959.13/1041620

►

Masters Research - Master of Philosophy (MPhil)

This thesis attempts to improve the clinical probability of correctly staging the degree of Alzheimer’s Disease (AD) neuropathology… (more)

Subjects/Keywords: Hippocampus; Alzheimer’s Disease; Apolipoprotein E

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APA (6^th Edition):

Walsh, B. A. (2014). The relationship between early Alzheimer’s Disease, Apolipoprotein E genotyping & Hippocampal MRI Volumes. (Masters Thesis). University of Newcastle. Retrieved from http://hdl.handle.net/1959.13/1041620

Chicago Manual of Style (16^th Edition):

Walsh, Bernard Anthony. “The relationship between early Alzheimer’s Disease, Apolipoprotein E genotyping & Hippocampal MRI Volumes.” 2014. Masters Thesis, University of Newcastle. Accessed February 26, 2021. http://hdl.handle.net/1959.13/1041620.

MLA Handbook (7^th Edition):

Walsh, Bernard Anthony. “The relationship between early Alzheimer’s Disease, Apolipoprotein E genotyping & Hippocampal MRI Volumes.” 2014. Web. 26 Feb 2021.

Vancouver:

Walsh BA. The relationship between early Alzheimer’s Disease, Apolipoprotein E genotyping & Hippocampal MRI Volumes. [Internet] [Masters thesis]. University of Newcastle; 2014. [cited 2021 Feb 26]. Available from: http://hdl.handle.net/1959.13/1041620.

Council of Science Editors:

Walsh BA. The relationship between early Alzheimer’s Disease, Apolipoprotein E genotyping & Hippocampal MRI Volumes. [Masters Thesis]. University of Newcastle; 2014. Available from: http://hdl.handle.net/1959.13/1041620

University of Toronto

30. Hou, Yi Bo. Mechanisms of Neurogenesis Mediated Forgetting.

Degree: 2016, University of Toronto

URL: http://hdl.handle.net/1807/74878

►

Memories allow experiences to have some permanence in our minds. Increasing adult neurogenesis in the dentate gyrus of the hippocampus has been shown to reduce… (more)

Subjects/Keywords: Dentate gyrus; Forgetting; Hippocampus; 0317

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APA (6^th Edition):

Hou, Y. B. (2016). Mechanisms of Neurogenesis Mediated Forgetting. (Masters Thesis). University of Toronto. Retrieved from http://hdl.handle.net/1807/74878

Chicago Manual of Style (16^th Edition):

Hou, Yi Bo. “Mechanisms of Neurogenesis Mediated Forgetting.” 2016. Masters Thesis, University of Toronto. Accessed February 26, 2021. http://hdl.handle.net/1807/74878.

MLA Handbook (7^th Edition):

Hou, Yi Bo. “Mechanisms of Neurogenesis Mediated Forgetting.” 2016. Web. 26 Feb 2021.

Vancouver:

Hou YB. Mechanisms of Neurogenesis Mediated Forgetting. [Internet] [Masters thesis]. University of Toronto; 2016. [cited 2021 Feb 26]. Available from: http://hdl.handle.net/1807/74878.

Council of Science Editors:

Hou YB. Mechanisms of Neurogenesis Mediated Forgetting. [Masters Thesis]. University of Toronto; 2016. Available from: http://hdl.handle.net/1807/74878

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