subject:(Hippocampus)

University of Georgia

1. Mathilakath Keralapurath, Madhusudhanan. Factors affecting the synaptic plasticity of hippocampus: focus on stress and addiction.

Degree: PhD, Toxicology, 2014, University of Georgia

URL: http://purl.galileo.usg.edu/uga_etd/mathilakath-keralapurath_madhusudhanan_201405_phd

► Involvement of the hippocampus in learning and memory is well known. Despite maintaining a uniform intrinsic circuitry throughout the structure, there are evidences for significant… (more)

▼ Involvement of the hippocampus in learning and memory is well known. Despite maintaining a uniform intrinsic circuitry throughout the structure, there are evidences for significant functional differences between the septal (dorsal) and temporal (ventral) sectors of hippocampus. Appreciation for the role of ventral hippocampus in the emotive and reward associated behaviors is on the rise. Behavioral and lesion studies in rodents have suggested that hippocampus plays an important role in drug reinstatement behaviors, although confirmatory molecular and electrophysiological evidences are lacking in this aspect. To study the effects of cocaine, we employed either the locomotor sensitization protocol where the drug was non-contingently administered by the experimenter, or we utilized the self-administration protocol where the rats were allowed to voluntarily administer drugs. Additionally, hippocampal feedback regulation of the hypothalamus-pituitary-adrenal axis is critical in the body’s response to stress. We investigated the effects of minor stressors such as novelty, handling and i.p. injections associated with a locomotor sensitization protocol on the hippocampal synaptic plasticity. We found that the minor, intermittent stressors associated with commonly employed behavioral protocols were sufficient to induce persistent stress-like effects. Cocaine, either experimenter administered or self-administered by the rats, specifically altered synaptic properties in the ventral hippocampus, albeit in different ways. Non-contingent cocaine exposures acted as metaplastic triggers and persistently enhanced the artificially induced LTP in the ventral hippocampus for at least 2 weeks after the last injection. In contrast, cocaine self-administration resulted in persistent enhancement of basal synaptic transmission in the ventral hippocampus, with both increases in excitatory glutamatergic activity and suppression of GABAergic inhibition being observed. Unlike in the non-contingently exposed groups, cocaine self-administration resulted in the suppression of LTP in the ventral hippocampus, suggesting a causal link between impaired learning and addicted states observed in the human subjects. Increased sensitivity of the ventral sector of the hippocampus to stress and drugs of abuse indicate its importance in the neuronal circuitry as a key intersection point where these co-morbidities of stress and drugs of abuse overlap. Advisors/Committee Members: John Wagner.

Subjects/Keywords: hippocampus

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Mathilakath Keralapurath, M. (2014). Factors affecting the synaptic plasticity of hippocampus: focus on stress and addiction. (Doctoral Dissertation). University of Georgia. Retrieved from http://purl.galileo.usg.edu/uga_etd/mathilakath-keralapurath_madhusudhanan_201405_phd

Chicago Manual of Style (16^th Edition):

Mathilakath Keralapurath, Madhusudhanan. “Factors affecting the synaptic plasticity of hippocampus: focus on stress and addiction.” 2014. Doctoral Dissertation, University of Georgia. Accessed April 20, 2018. http://purl.galileo.usg.edu/uga_etd/mathilakath-keralapurath_madhusudhanan_201405_phd.

MLA Handbook (7^th Edition):

Mathilakath Keralapurath, Madhusudhanan. “Factors affecting the synaptic plasticity of hippocampus: focus on stress and addiction.” 2014. Web. 20 Apr 2018.

Vancouver:

Mathilakath Keralapurath M. Factors affecting the synaptic plasticity of hippocampus: focus on stress and addiction. [Internet] [Doctoral dissertation]. University of Georgia; 2014. [cited 2018 Apr 20]. Available from: http://purl.galileo.usg.edu/uga_etd/mathilakath-keralapurath_madhusudhanan_201405_phd.

Council of Science Editors:

Mathilakath Keralapurath M. Factors affecting the synaptic plasticity of hippocampus: focus on stress and addiction. [Doctoral Dissertation]. University of Georgia; 2014. Available from: http://purl.galileo.usg.edu/uga_etd/mathilakath-keralapurath_madhusudhanan_201405_phd

Wake Forest University

2. Haynes, Kathryn Alice. The Role of Ubiquitin-Proteasome-Mediated Proteolysis in Long-term Synaptic Plasticity.

Degree: 2015, Wake Forest University

URL: http://hdl.handle.net/10339/57156

► Elucidating mechanisms by which synapses are modified for long-term memory storage is crucial for explaining normal brain function as well as diseases and disorders of… (more)

▼ Elucidating mechanisms by which synapses are modified for long-term memory storage is crucial for explaining normal brain function as well as diseases and disorders of the brain. Numerous studies have shown that new gene expression and new protein synthesis are essential for the synaptic changes that give rise to long-term memory. More recent studies indicate that proteolysis by the ubiquitin-proteasome pathway (UPP) plays a critical role in long-term synaptic plasticity, and dysregulation of this pathway is associated with cognitive impairments in neurodegenerative diseases such as Alzheimer’s, Parkinson’s, and Huntington’s disease. Using the cellular model for long-term synaptic plasticity, late-phase long-term potentiation (L-LTP), our work reveals intricate interactions between proteolysis, protein synthesis in the dendrites and gene transcription in the nucleus. Previously, we showed that the early induction phase of L-LTP, which depends on local protein synthesis within dendrites, is enhanced by proteasome inhibition. We also observed that the later maintenance phase of L-LTP, which relies on translation of newly transcribed mRNAs, is blocked when the proteasome is inhibited. We hypothesized that the proteasome must be regulating both phases of L-LTP by controlling translation within dendrites and transcription within the nucleus. Supporting this hypothesis, we found two translational activators that increase early in L-LTP and two translational repressors that buildup later in L-LTP. Inhibition of the proteasome prior to L-LTP resulted in significant increases in expression of both translation activators and repressors, suggesting that this temporal regulation of translation might contribute to the proteasome’s role in the regulation of L-LTP induction and maintenance. In addition, proteasome inhibition prior to LTP induction significantly increases overall protein synthesis and initially slows protein degradation. Interestingly, we also found that amyloid –β (Aβ) drastically decreases basal and activity-dependent protein synthesis, while proteasome inhibition prior to Aβ treatment rescues this decrease back to control and LTP levels, respectively. Finally, taking a step away from translation and investigating the role of the proteasome in transcriptional regulation, we found that a transcriptional repressor, ATF4, is phosphorylated and degraded early in LTP, indicating a potential critical role for the proteasome in relieving repression of transcription during memory consolidation. These findings shed light on the proteasome-dependent mechanisms behind gene and protein expression in synaptic plasticity and could aide in finding novel therapeutic targets and biomarkers for ameliorating memory impairments in neurodegenerative diseases.

Subjects/Keywords: Hippocampus

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Haynes, K. A. (2015). The Role of Ubiquitin-Proteasome-Mediated Proteolysis in Long-term Synaptic Plasticity. (Thesis). Wake Forest University. Retrieved from http://hdl.handle.net/10339/57156

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Haynes, Kathryn Alice. “The Role of Ubiquitin-Proteasome-Mediated Proteolysis in Long-term Synaptic Plasticity.” 2015. Thesis, Wake Forest University. Accessed April 20, 2018. http://hdl.handle.net/10339/57156.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Haynes, Kathryn Alice. “The Role of Ubiquitin-Proteasome-Mediated Proteolysis in Long-term Synaptic Plasticity.” 2015. Web. 20 Apr 2018.

Vancouver:

Haynes KA. The Role of Ubiquitin-Proteasome-Mediated Proteolysis in Long-term Synaptic Plasticity. [Internet] [Thesis]. Wake Forest University; 2015. [cited 2018 Apr 20]. Available from: http://hdl.handle.net/10339/57156.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Haynes KA. The Role of Ubiquitin-Proteasome-Mediated Proteolysis in Long-term Synaptic Plasticity. [Thesis]. Wake Forest University; 2015. Available from: http://hdl.handle.net/10339/57156

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Texas – Austin

3. Clemens, Ann M. Adaptive responses to cellular stress in neurons of the hippocampus.

Degree: Neuroscience, 2013, University of Texas – Austin

URL: http://hdl.handle.net/2152/26613

► Disruptions of endoplasmic reticulum (ER) Ca²⁺ homeostasis are heavily linked to neuronal pathology. Depletion of ER Ca²⁺ stores can result in cellular dysfunction and potentially… (more)

Subjects/Keywords: Hippocampus

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Clemens, A. M. (2013). Adaptive responses to cellular stress in neurons of the hippocampus. (Thesis). University of Texas – Austin. Retrieved from http://hdl.handle.net/2152/26613

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Clemens, Ann M. “Adaptive responses to cellular stress in neurons of the hippocampus.” 2013. Thesis, University of Texas – Austin. Accessed April 20, 2018. http://hdl.handle.net/2152/26613.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Clemens, Ann M. “Adaptive responses to cellular stress in neurons of the hippocampus.” 2013. Web. 20 Apr 2018.

Vancouver:

Clemens AM. Adaptive responses to cellular stress in neurons of the hippocampus. [Internet] [Thesis]. University of Texas – Austin; 2013. [cited 2018 Apr 20]. Available from: http://hdl.handle.net/2152/26613.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Clemens AM. Adaptive responses to cellular stress in neurons of the hippocampus. [Thesis]. University of Texas – Austin; 2013. Available from: http://hdl.handle.net/2152/26613

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of New Mexico

4. Scullin, Chessa. Development of presynaptic calcium dynamics and short-term plasticity in the SC-Ca1 synapse.

Degree: Biomedical Sciences Graduate Program, 2010, University of New Mexico

URL: http://digitalrepository.unm.edu/biom_etds/18

► Following a presynaptic action potential, there is a rapid rise of [Ca2+]i in the immediate vicinity of Ca2+ channels that triggers membrane fusion and release… (more)

▼ Following a presynaptic action potential, there is a rapid rise of [Ca2+]i in the immediate vicinity of Ca2+ channels that triggers membrane fusion and release of transmitter from vesicles within this microdomain. This presynaptic Ca2+ signal ([Ca2+]pre) then disperses to produce a residual Ca2+ ([Ca2+]res) that decays over the course of tens to hundreds of milliseconds. The [Ca2+]res has important implications in synaptic plasticity and is the basis for working memory storage. Ultimately [Ca2+]res is removed from the cytoplasm either into intracellular organelles or across the plasma membrane into the extracellular environment. Calcium influx pathways, cytoplasmic Ca2+ buffering proteins, and Ca2+ extrusion processes in rodent neurons undergo considerable change during the first postnatal month. These changes have important functional significance in short-term plasticity — in particular paired-pulse facilitation (PPF) — at presynaptic terminals where neurotransmitter release is directly dependent on the dynamics of free cytoplasmic Ca2+. To examine developmental changes in [Ca2+]res dynamics in the Schaffer collateral synapses onto CA1 pyramidal neurons in in vitro hippocampal slices, we measured the timecourse of decay of [Ca2+]res in presynaptic terminals following single and paired orthodromic stimuli in the stratum radiatum. The contribution of the slow component compared to the total decay of [Ca2+]res was reduced from >80% in newborn mice to ~50% in the more mature animals (>P24) and [Ca2+]res had a distinct slow rising component in newborn mice (<P4), which was not apparent in older mice. This transition from a slow decay in early neonatal periods to the rapid decay in adults occurred gradually over the first 4 weeks of postnatal life, and appeared to be coincident with the major period of maturation of these synapses. The first goal of this study was to investigate the role of internal stores in regulating presynaptic [Ca2+] and in synaptic plasticity during this important period of synaptic development. During this same developmental period, SNAP-25, a presynaptic vesicular release protein, undergoes changes in isoform expression. Alterations in SNAP-25 isoform expression have been linked to diseases with developmental onset such as schizophrenia, attention deficit hyperactivity disorder, and epilepsy (Corradini et al., 2009). Snap25tm2Mcw mice (Tkneo), in which this developmental change of isoform expression is modified (Bark et al., 2004), appear to retain an immature state of paired-pulse facilitation. The second goal of this study was to use these Tkneo mice as a tool to better understand the mechanisms of synaptic plasticity and to better understand how SNAP-25 regulation could underlie neurological disorders. We applied a model for paired-pulse facilitation (Schiess et al., 2006), which describes facilitation as a function of two [Ca2+]res-dependent pools of vesicles with different release probabilities. This model predicted the observed external [Ca2+]-dependent changes in… Advisors/Committee Members: Partridge, L. Donald, Wilson, Michael, Thomas, James, Hartley, Rebecca, Shuttleworth, C. William.

Subjects/Keywords: calcium; hippocampus

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Scullin, C. (2010). Development of presynaptic calcium dynamics and short-term plasticity in the SC-Ca1 synapse. (Doctoral Dissertation). University of New Mexico. Retrieved from http://digitalrepository.unm.edu/biom_etds/18

Chicago Manual of Style (16^th Edition):

Scullin, Chessa. “Development of presynaptic calcium dynamics and short-term plasticity in the SC-Ca1 synapse.” 2010. Doctoral Dissertation, University of New Mexico. Accessed April 20, 2018. http://digitalrepository.unm.edu/biom_etds/18.

MLA Handbook (7^th Edition):

Scullin, Chessa. “Development of presynaptic calcium dynamics and short-term plasticity in the SC-Ca1 synapse.” 2010. Web. 20 Apr 2018.

Vancouver:

Scullin C. Development of presynaptic calcium dynamics and short-term plasticity in the SC-Ca1 synapse. [Internet] [Doctoral dissertation]. University of New Mexico; 2010. [cited 2018 Apr 20]. Available from: http://digitalrepository.unm.edu/biom_etds/18.

Council of Science Editors:

Scullin C. Development of presynaptic calcium dynamics and short-term plasticity in the SC-Ca1 synapse. [Doctoral Dissertation]. University of New Mexico; 2010. Available from: http://digitalrepository.unm.edu/biom_etds/18

University of Alberta

5. McEown, Kristopher. The roles of the dorsal and ventral hippocampus in fear and memory of a shock probe experience.

Degree: MS, Department of Psychology, 2009, University of Alberta

URL: https://era.library.ualberta.ca/files/2f75r905d

► This thesis examined the effects of temporary inactivation of the dorsal or ventral hippocampus on unconditioned and conditioned fear, using the shock-probe test. Rats received… (more)

Subjects/Keywords: fear; hippocampus; memory

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

McEown, K. (2009). The roles of the dorsal and ventral hippocampus in fear and memory of a shock probe experience. (Masters Thesis). University of Alberta. Retrieved from https://era.library.ualberta.ca/files/2f75r905d

Chicago Manual of Style (16^th Edition):

McEown, Kristopher. “The roles of the dorsal and ventral hippocampus in fear and memory of a shock probe experience.” 2009. Masters Thesis, University of Alberta. Accessed April 20, 2018. https://era.library.ualberta.ca/files/2f75r905d.

MLA Handbook (7^th Edition):

McEown, Kristopher. “The roles of the dorsal and ventral hippocampus in fear and memory of a shock probe experience.” 2009. Web. 20 Apr 2018.

Vancouver:

McEown K. The roles of the dorsal and ventral hippocampus in fear and memory of a shock probe experience. [Internet] [Masters thesis]. University of Alberta; 2009. [cited 2018 Apr 20]. Available from: https://era.library.ualberta.ca/files/2f75r905d.

Council of Science Editors:

McEown K. The roles of the dorsal and ventral hippocampus in fear and memory of a shock probe experience. [Masters Thesis]. University of Alberta; 2009. Available from: https://era.library.ualberta.ca/files/2f75r905d

Rutgers University

6. Montgomery, Sean M. The functional anatomy of hippocampal theta and gamma oscillations.

Degree: PhD, Integrative Neuroscience, 2009, Rutgers University

URL: http://hdl.rutgers.edu/1782.2/rucore10002600001.ETD.000051286

►

This dissertation investigated how theta (4-10Hz) and gamma (40-100Hz) oscillations are coordinated across different hippocampal subnetworks during different behaviors. Using 96-site silicon probes to simultaneously… (more)

▼

This dissertation investigated how theta (4-10Hz) and gamma (40-100Hz) oscillations are coordinated across different hippocampal subnetworks during different behaviors. Using 96-site silicon probes to simultaneously record local field potentials (LFPs) and unit activity from dendritic and somatic layers of the dentate gyrus, CA3 and CA1 regions, I examined how local field potentials (LFPs) and unit activity changed the theta and gamma synchronization of hippocampal networks as a function of behavior. Specifically, I compared hippocampal activity of rats during performance of a hippocampus-dependent delayed spatial alternation task on a modified T-maze versus performance of non-mnemonic control tasks. I also compared hippocampal network activity during active waking behavior versus rapid eye movement (REM) sleep. The first study examined how theta oscillations throughout the hippocampal subnetworks change during behavioral task performance. Although theta oscillations were generally highly coherent throughout the system, I found that the power, coherence and phase of theta oscillations fluctuated in a layer-specific manner, suggesting the presence of multiple interdependent dipoles. I also found layer-specific changes in theta power and coherence during different portions of both alternation and control tasks, as well as a decreased phase lag between CA3 and CA1 theta oscillations on the center arm of the T-maze compared to other segments of the alternation and control tasks. The second study examined changes in hippocampal gamma oscillations during performance of the alternation and control tasks. This study found that on the center arm of the T-maze, the power and coherence of gamma oscillations at the CA3-CA1 interface increased compared to other segments in the alternation task or compared to control task segments. The third study examined changes in theta and gamma coordination of hippocampal networks during active waking versus REM sleep. I found increased dentate/CA3 theta and gamma synchrony, but decreased CA3-CA1 gamma coordination during REM sleep. I also detected phasic bursts of LFP power in the dentate molecular layer that divided REM sleep into phasic and tonic periods. Although tonic periods characterized the majority of REM sleep epochs (~95%), phasic periods exhibited transient increases in theta and gamma coordination among all of the hippocampal subregions.

Advisors/Committee Members: Montgomery, Sean M. (author), Tepper, James (chair), Pare, Denis (internal member), Harris, Kenneth (internal member), Buzsaki, Gyorgy (internal member), Kahana, Michael (outside member).

Subjects/Keywords: Hippocampus (Brain); Oscillations

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Montgomery, S. M. (2009). The functional anatomy of hippocampal theta and gamma oscillations. (Doctoral Dissertation). Rutgers University. Retrieved from http://hdl.rutgers.edu/1782.2/rucore10002600001.ETD.000051286

Chicago Manual of Style (16^th Edition):

Montgomery, Sean M. “The functional anatomy of hippocampal theta and gamma oscillations.” 2009. Doctoral Dissertation, Rutgers University. Accessed April 20, 2018. http://hdl.rutgers.edu/1782.2/rucore10002600001.ETD.000051286.

MLA Handbook (7^th Edition):

Montgomery, Sean M. “The functional anatomy of hippocampal theta and gamma oscillations.” 2009. Web. 20 Apr 2018.

Vancouver:

Montgomery SM. The functional anatomy of hippocampal theta and gamma oscillations. [Internet] [Doctoral dissertation]. Rutgers University; 2009. [cited 2018 Apr 20]. Available from: http://hdl.rutgers.edu/1782.2/rucore10002600001.ETD.000051286.

Council of Science Editors:

Montgomery SM. The functional anatomy of hippocampal theta and gamma oscillations. [Doctoral Dissertation]. Rutgers University; 2009. Available from: http://hdl.rutgers.edu/1782.2/rucore10002600001.ETD.000051286

7. Toritsuka, Michihiro; Kimoto, Sohei; Muraki, Kazue; Landek-Salgado, Melissa A; Yoshida, Atsuhiro; Yamamoto, Norio; Horiuchi, Yasue; Hiyama, Hideki; Tajinda, Katsunori; Keni, Ni; Illingworth, Elizabeth; Iwamoto, Takashi; Kishimoto, Toshifumi; Sawa, Akira. Deficits in microRNA-mediated Cxcr4/Cxcl12 signaling in neurodevelopmental deficits in a 22q11 deletion syndrome mouse model. : 22q11欠失症候群モデルマウスの神経発達障害には、マイクロRNAが介在するCxcr4/Cxcl12シグナリングの欠損が寄与する.

Degree: 博士（医学）, 2014, Nara Medical University / 奈良県立医科大学

URL: http://hdl.handle.net/10564/2716

►

22q11 deletion syndrome (22q11DS) frequently accompanies psychiatric conditions, some of which are classified as schizophrenia and bipolar disorder in the current diagnostic categorization. However, it… (more)

Subjects/Keywords: hippocampus; dentate gyrus

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Toritsuka, Michihiro; Kimoto, Sohei; Muraki, Kazue; Landek-Salgado, Melissa A; Yoshida, Atsuhiro; Yamamoto, Norio; Horiuchi, Yasue; Hiyama, Hideki; Tajinda, Katsunori; Keni, Ni; Illingworth, Elizabeth; Iwamoto, Takashi; Kishimoto, Toshifumi; Sawa, A. (2014). Deficits in microRNA-mediated Cxcr4/Cxcl12 signaling in neurodevelopmental deficits in a 22q11 deletion syndrome mouse model. : 22q11欠失症候群モデルマウスの神経発達障害には、マイクロRNAが介在するCxcr4/Cxcl12シグナリングの欠損が寄与する. (Thesis). Nara Medical University / 奈良県立医科大学. Retrieved from http://hdl.handle.net/10564/2716

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Toritsuka, Michihiro; Kimoto, Sohei; Muraki, Kazue; Landek-Salgado, Melissa A; Yoshida, Atsuhiro; Yamamoto, Norio; Horiuchi, Yasue; Hiyama, Hideki; Tajinda, Katsunori; Keni, Ni; Illingworth, Elizabeth; Iwamoto, Takashi; Kishimoto, Toshifumi; Sawa, Akira. “Deficits in microRNA-mediated Cxcr4/Cxcl12 signaling in neurodevelopmental deficits in a 22q11 deletion syndrome mouse model. : 22q11欠失症候群モデルマウスの神経発達障害には、マイクロRNAが介在するCxcr4/Cxcl12シグナリングの欠損が寄与する.” 2014. Thesis, Nara Medical University / 奈良県立医科大学. Accessed April 20, 2018. http://hdl.handle.net/10564/2716.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Toritsuka, Michihiro; Kimoto, Sohei; Muraki, Kazue; Landek-Salgado, Melissa A; Yoshida, Atsuhiro; Yamamoto, Norio; Horiuchi, Yasue; Hiyama, Hideki; Tajinda, Katsunori; Keni, Ni; Illingworth, Elizabeth; Iwamoto, Takashi; Kishimoto, Toshifumi; Sawa, Akira. “Deficits in microRNA-mediated Cxcr4/Cxcl12 signaling in neurodevelopmental deficits in a 22q11 deletion syndrome mouse model. : 22q11欠失症候群モデルマウスの神経発達障害には、マイクロRNAが介在するCxcr4/Cxcl12シグナリングの欠損が寄与する.” 2014. Web. 20 Apr 2018.

Vancouver:

Toritsuka, Michihiro; Kimoto, Sohei; Muraki, Kazue; Landek-Salgado, Melissa A; Yoshida, Atsuhiro; Yamamoto, Norio; Horiuchi, Yasue; Hiyama, Hideki; Tajinda, Katsunori; Keni, Ni; Illingworth, Elizabeth; Iwamoto, Takashi; Kishimoto, Toshifumi; Sawa A. Deficits in microRNA-mediated Cxcr4/Cxcl12 signaling in neurodevelopmental deficits in a 22q11 deletion syndrome mouse model. : 22q11欠失症候群モデルマウスの神経発達障害には、マイクロRNAが介在するCxcr4/Cxcl12シグナリングの欠損が寄与する. [Internet] [Thesis]. Nara Medical University / 奈良県立医科大学; 2014. [cited 2018 Apr 20]. Available from: http://hdl.handle.net/10564/2716.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Toritsuka, Michihiro; Kimoto, Sohei; Muraki, Kazue; Landek-Salgado, Melissa A; Yoshida, Atsuhiro; Yamamoto, Norio; Horiuchi, Yasue; Hiyama, Hideki; Tajinda, Katsunori; Keni, Ni; Illingworth, Elizabeth; Iwamoto, Takashi; Kishimoto, Toshifumi; Sawa A. Deficits in microRNA-mediated Cxcr4/Cxcl12 signaling in neurodevelopmental deficits in a 22q11 deletion syndrome mouse model. : 22q11欠失症候群モデルマウスの神経発達障害には、マイクロRNAが介在するCxcr4/Cxcl12シグナリングの欠損が寄与する. [Thesis]. Nara Medical University / 奈良県立医科大学; 2014. Available from: http://hdl.handle.net/10564/2716

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Victoria

8. Simpson, Jessica M. Altered Adult Hippocampal Structural and Functional Plasticity in the YAC128 Transgenic Mouse Model of Huntington Disease.

Degree: Dept. of Biology, 2013, University of Victoria

URL: http://hdl.handle.net/1828/4978

► Alterations in both structural and synaptic plasticity in the adult brain have been implicated in impaired learning and memory. In the present study, we investigated… (more)

Subjects/Keywords: Huntington's chorea; Hippocampus

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Simpson, J. M. (2013). Altered Adult Hippocampal Structural and Functional Plasticity in the YAC128 Transgenic Mouse Model of Huntington Disease. (Masters Thesis). University of Victoria. Retrieved from http://hdl.handle.net/1828/4978

Chicago Manual of Style (16^th Edition):

Simpson, Jessica M. “Altered Adult Hippocampal Structural and Functional Plasticity in the YAC128 Transgenic Mouse Model of Huntington Disease.” 2013. Masters Thesis, University of Victoria. Accessed April 20, 2018. http://hdl.handle.net/1828/4978.

MLA Handbook (7^th Edition):

Simpson, Jessica M. “Altered Adult Hippocampal Structural and Functional Plasticity in the YAC128 Transgenic Mouse Model of Huntington Disease.” 2013. Web. 20 Apr 2018.

Vancouver:

Simpson JM. Altered Adult Hippocampal Structural and Functional Plasticity in the YAC128 Transgenic Mouse Model of Huntington Disease. [Internet] [Masters thesis]. University of Victoria; 2013. [cited 2018 Apr 20]. Available from: http://hdl.handle.net/1828/4978.

Council of Science Editors:

Simpson JM. Altered Adult Hippocampal Structural and Functional Plasticity in the YAC128 Transgenic Mouse Model of Huntington Disease. [Masters Thesis]. University of Victoria; 2013. Available from: http://hdl.handle.net/1828/4978

Tulane University

9. Homiack, Damek. Mechanisms by which Acute or Chronic Stress Exposure Modulates CREB Phosphorylation in the Hippocampus in a Sex-Specific Manner.

Degree: 2017, Tulane University

URL: https://digitallibrary.tulane.edu/islandora/object/tulane:75315

►

Women are at greater risk to develop the incurable psychiatric diseases posttraumatic stress disorder (PTSD) and major depressive disorder (MDD). In spite of the elevated… (more)

▼

Women are at greater risk to develop the incurable psychiatric diseases posttraumatic stress disorder (PTSD) and major depressive disorder (MDD). In spite of the elevated risk associated with female biological sex, the vast majority of preclinical studies have exclusively used male rodents. Therefore, the neurobiology which underlies the increased susceptibility to stress-related mental illness associated with female sex is largely unknown. Currently, it is thought that regulation of the transcription factor cyclic-AMP response element binding protein (CREB) may act as a molecular locus capable of transducing aversive experiences into lasting changes in the structure and function of neurons in the hippocampus. However, the signal transduction cascades recruited by stress to modulate CREB activity are less well understood. Therefore, the goal of this thesis was to investigate stress-induced modulation of CREB phosphorylation and upstream signaling cascades in the hippocampus of male and female rodents exposed to severe stress. Exposure to either acute predator odor stress or chronic variable stress reduced phosphorylation of CREB in the male, but not the female hippocampus. Predator odor exposure rapidly reduced phosphorylation of extracellular signal-regulated kinase and increased nuclear expression of the synapto-nuclear messenger protein Jacob in the male hippocampus, consistent with the previously described CREB shut-off cascade. Chronic variable stress affected the activity of Sirtuin1, a metabolically-sensitive deacetylase known to interact with CREB, in the male, but not the female dentate gyrus sub-area of the hippocampus, possibly through recruitment of adenosine monophosphate activated protein kinase. Behaviorally, female rodents exposed to predator odor exhibited an impaired ability to discriminate between a context previously paired with the predator odor and a neutral context, possibly representing a fear over-generalizing phenotype. In contrast female rodents exposed to chronic variable stress did not exhibit the altered metabolic phenotypes observed in male rodents exposed to chronic variable stress, suggesting that females are more resilient to chronic stress. Collectively, these data suggest that the female hippocampus resists changes in CREB phosphorylation associated with severe stress which may contribute to sex differences observed in stress-related mental health disorders.

1

Damek Homiack

Advisors/Committee Members: (author), Schrader, Laura (Thesis advisor), (Thesis advisor), School of Science & Engineering Neuroscience (Degree granting institution), NULL (Degree granting institution).

Subjects/Keywords: Hippocampus; CREB; Stress

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Homiack, D. (2017). Mechanisms by which Acute or Chronic Stress Exposure Modulates CREB Phosphorylation in the Hippocampus in a Sex-Specific Manner. (Thesis). Tulane University. Retrieved from https://digitallibrary.tulane.edu/islandora/object/tulane:75315

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Homiack, Damek. “Mechanisms by which Acute or Chronic Stress Exposure Modulates CREB Phosphorylation in the Hippocampus in a Sex-Specific Manner.” 2017. Thesis, Tulane University. Accessed April 20, 2018. https://digitallibrary.tulane.edu/islandora/object/tulane:75315.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Homiack, Damek. “Mechanisms by which Acute or Chronic Stress Exposure Modulates CREB Phosphorylation in the Hippocampus in a Sex-Specific Manner.” 2017. Web. 20 Apr 2018.

Vancouver:

Homiack D. Mechanisms by which Acute or Chronic Stress Exposure Modulates CREB Phosphorylation in the Hippocampus in a Sex-Specific Manner. [Internet] [Thesis]. Tulane University; 2017. [cited 2018 Apr 20]. Available from: https://digitallibrary.tulane.edu/islandora/object/tulane:75315.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Homiack D. Mechanisms by which Acute or Chronic Stress Exposure Modulates CREB Phosphorylation in the Hippocampus in a Sex-Specific Manner. [Thesis]. Tulane University; 2017. Available from: https://digitallibrary.tulane.edu/islandora/object/tulane:75315

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Cornell University

10. Law, Loren. Contextual Learning In The Limbic Memory Circuit .

Degree: 2015, Cornell University

URL: http://hdl.handle.net/1813/39373

► Context plays a critical role in memory. Information obtained during learning gets bound to the context and the context itself can serve as a potent… (more)

▼ Context plays a critical role in memory. Information obtained during learning gets bound to the context and the context itself can serve as a potent retrieval cue. It has been well known since the 1970's that the hippocampus (HP) plays a critical role in processing contextual information. Research has shown that learning two lists of items in two different contexts facilitates learning compared to learning both in one context, and damage to the HP abolishes this advantage. Electrophysiology studies have indicated the HP forms contextual representations of an environment quickly and that the representation remains stable thereafter. The HP also encodes non-spatial information such as events, cues and time. The HP and AT are strongly interconnected and it is well known now that damage to the anterior thalamic nuclei (AT) produces severe memory deficits in multiple memory domains similar that following damage to the HP. However, it is not known whether the AT is critically involved in contextual memory processes like the HP. The first chapter evaluated whether the AT is involved in contextual learning of a context dependent odor discrimination task. The results showed that like the HP, damage to the AT abolishes the contextual advantage of learning two sets of odor discrimination problems in separate contexts. The second chapter evaluated how neuronal representations in the HP change when learning two contexts concurrently. While studies have evaluated how neuronal representations change between context exposures, none have evaluated the concurrent development of two contexts. The results showed that several exposures to the same context are required to form a stable HP representation of the two contexts. The final iii chapter evaluated what event responses arise when learning the same task as chapter one and how these event representations change with learning. The results show that as learning progressed, event responses decreased in number. This decrease may be due to the responses becoming part of a general trial sequence indicating the stabilization of the representation as learning progressed. The current dissertation provides new evidence for how the memory circuit encodes contextual memory. iv Advisors/Committee Members: Regan, Elizabeth (committeeMember), Devoogd, Timothy John (committeeMember), Cutting, James Eric (committeeMember).

Subjects/Keywords: Context; Hippocampus; elctrophysiology

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Law, L. (2015). Contextual Learning In The Limbic Memory Circuit . (Thesis). Cornell University. Retrieved from http://hdl.handle.net/1813/39373

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Law, Loren. “Contextual Learning In The Limbic Memory Circuit .” 2015. Thesis, Cornell University. Accessed April 20, 2018. http://hdl.handle.net/1813/39373.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Law, Loren. “Contextual Learning In The Limbic Memory Circuit .” 2015. Web. 20 Apr 2018.

Vancouver:

Law L. Contextual Learning In The Limbic Memory Circuit . [Internet] [Thesis]. Cornell University; 2015. [cited 2018 Apr 20]. Available from: http://hdl.handle.net/1813/39373.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Law L. Contextual Learning In The Limbic Memory Circuit . [Thesis]. Cornell University; 2015. Available from: http://hdl.handle.net/1813/39373

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Rutgers University

11. Czerniawski, Jennifer, 1982-. NMDA receptor mediated expression of Arc in dorsal and ventral hippocampus contributes to the acquisition of contextual and trace fear conditioning.

Degree: PhD, Psychology, 2011, Rutgers University

URL: http://hdl.rutgers.edu/1782.1/rucore10001600001.ETD.000061173

►

The dorsal and ventral subregions of the hippocampus are differentially involved in several of types of learning, including fear conditioning. For example, we have previously… (more)

▼

The dorsal and ventral subregions of the hippocampus are differentially involved in several of types of learning, including fear conditioning. For example, we have previously demonstrated that the integrity of ventral, but not dorsal, hippocampus is necessary for the acquisition and expression of trace fear conditioning while dorsal, but not ventral, hippocampus is critically involved in spatially-guided reinforced alternation (Czerniawski, Yoon & Otto, 2009). In contrast to the partially dissociable effects of either lesions or inactivation, however, several lines of research suggest that, in intact subjects, both subregions are normally involved in the acquisition of many hippocampal-dependent tasks. The present studies investigated the molecular basis of these forms of learning by determining whether NMDA receptor-mediated immediate early gene expression in dorsal vs. ventral hippocampus contributes to the acquisition and/or retention of trace and contextual fear conditioning. In the first set of experiments we examined the effect of NMDA receptor antagonism in dorsal or ventral hippocampus on the acquisition or expression of trace and contextual fear conditioning. Next we assessed if trace fear conditioning alters the transcription and/or translation of Arc, an immediate early gene thought to be critically involved in some forms of plasticity and learning. In addition we examined the effect of blocking Arc translation with antisense oligodeoxynucleotides on the acquisition of CS-US associations in this paradigm. Lastly, in the final experiment we determined if the learning induced increase in Arc translation is NMDA receptor-dependent. The results of these studies suggest that both NMDA-receptor antagonism and the infusion of antisense oligodeoxynucleotides for the immediate early gene Arc (activity-regulated cytoskeletal protein) into dorsal or ventral hippocampus impair the acquisition of contextual and trace fear conditioning. In addition, trace fear conditioning enhances both Arc transcription and translation. Finally, pre-training infusions of either Arc antisense oligodeoxynucleotides or the NMDA receptor antagonist APV block the learning-induced enhancement of Arc. Together these studies support the notion that NMDA-receptor mediated expression of the immediate early gene Arc in both dorsal and ventral hippocampus may underlie the acquisition of a variety of forms of hippocampal dependent learning.

Advisors/Committee Members: Czerniawski, Jennifer, 1982- (author), Otto, Tim (chair), Shors, Tracey (internal member), McGann, John (internal member), Firestein, Bonnie (outside member).

Subjects/Keywords: Hippocampus (Brain); Fear

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Czerniawski, Jennifer, 1. (2011). NMDA receptor mediated expression of Arc in dorsal and ventral hippocampus contributes to the acquisition of contextual and trace fear conditioning. (Doctoral Dissertation). Rutgers University. Retrieved from http://hdl.rutgers.edu/1782.1/rucore10001600001.ETD.000061173

Chicago Manual of Style (16^th Edition):

Czerniawski, Jennifer, 1982-. “NMDA receptor mediated expression of Arc in dorsal and ventral hippocampus contributes to the acquisition of contextual and trace fear conditioning.” 2011. Doctoral Dissertation, Rutgers University. Accessed April 20, 2018. http://hdl.rutgers.edu/1782.1/rucore10001600001.ETD.000061173.

MLA Handbook (7^th Edition):

Czerniawski, Jennifer, 1982-. “NMDA receptor mediated expression of Arc in dorsal and ventral hippocampus contributes to the acquisition of contextual and trace fear conditioning.” 2011. Web. 20 Apr 2018.

Vancouver:

Czerniawski, Jennifer 1. NMDA receptor mediated expression of Arc in dorsal and ventral hippocampus contributes to the acquisition of contextual and trace fear conditioning. [Internet] [Doctoral dissertation]. Rutgers University; 2011. [cited 2018 Apr 20]. Available from: http://hdl.rutgers.edu/1782.1/rucore10001600001.ETD.000061173.

Council of Science Editors:

Czerniawski, Jennifer 1. NMDA receptor mediated expression of Arc in dorsal and ventral hippocampus contributes to the acquisition of contextual and trace fear conditioning. [Doctoral Dissertation]. Rutgers University; 2011. Available from: http://hdl.rutgers.edu/1782.1/rucore10001600001.ETD.000061173

University of Texas Southwestern Medical Center

12. Bulin, Sarah Elizabeth. The Role of Adult Hippocampal Neurogenesis in Morphine Addiction.

Degree: 2015, University of Texas Southwestern Medical Center

URL: http://hdl.handle.net/2152.5/4130

► The hippocampus plays a large role in modulating the reward pathway, being especially important in craving and context-dependent relapse. One form a neuroplasticity within the… (more)

▼ The hippocampus plays a large role in modulating the reward pathway, being especially important in craving and context-dependent relapse. One form a neuroplasticity within the hippocampus is adult neurogenesis, which occurs in the subgranular zone of the dentate gyrus. While a growing amount of literature has explored the effects of drugs of abuse on adult DG neurogenesis, the relationship between self-administered opiates and adult DG neurogenesis remains unexplored. This dissertation investigates both the role of adult DG neurogenesis in morphine-related behaviors and the effects of self-administered opiates (morphine and heroin) on adult DG neurogenesis. I first explore the background literature important in the work completed within this dissertation (Chapter 1). Next, using a self-administration paradigm, I proceed to show that ablation of adult neurogenesis via cranial irradiation results in increased in morphine intake, decreased extinction, and decreased cognitive flexibility. Additionally, rats lacking adult DG neurogenesis exhibited increased morphine locomotor sensitization with increased DG activation in the infrablade after a low dose morphine challenge (Chapter 2). I will then go on to investigate the consequences of long-term self-administered opiates (morphine and heroin) on the different stages of maturation of adult-generated neurons. I demonstrate that morphine self-administration has no effect on proliferation, survival, or maturation immediately after exposure or after 28 days of withdrawal (Chapter 3). Additionally, I demonstrate that heroin self-administration does not alter DCX+ cell density or granule cell layer volume (Chapter 4). Taken together, my data suggests the adult DG neurogenesis is robust and normally unaffected by self-administered opiates. However, preexisting deficits in DG neurogenesis may lead to an increased vulnerability to addiction-related behaviors. In the final chapter (Chapter 5), I discuss potential implications of this work and future directions in which it may be taken. Advisors/Committee Members: Hsieh, Jenny, Self, David W., Powell, Craig M., Eisch, Amelia J..

Subjects/Keywords: Hippocampus; Morphine; Neurogenesis

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Bulin, S. E. (2015). The Role of Adult Hippocampal Neurogenesis in Morphine Addiction. (Thesis). University of Texas Southwestern Medical Center. Retrieved from http://hdl.handle.net/2152.5/4130

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Bulin, Sarah Elizabeth. “The Role of Adult Hippocampal Neurogenesis in Morphine Addiction.” 2015. Thesis, University of Texas Southwestern Medical Center. Accessed April 20, 2018. http://hdl.handle.net/2152.5/4130.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Bulin, Sarah Elizabeth. “The Role of Adult Hippocampal Neurogenesis in Morphine Addiction.” 2015. Web. 20 Apr 2018.

Vancouver:

Bulin SE. The Role of Adult Hippocampal Neurogenesis in Morphine Addiction. [Internet] [Thesis]. University of Texas Southwestern Medical Center; 2015. [cited 2018 Apr 20]. Available from: http://hdl.handle.net/2152.5/4130.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Bulin SE. The Role of Adult Hippocampal Neurogenesis in Morphine Addiction. [Thesis]. University of Texas Southwestern Medical Center; 2015. Available from: http://hdl.handle.net/2152.5/4130

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Otago

13. Seo, Steve. Spatial Learning-Induced Changes at Agmatinergic and Glutamatergic Synapses in the Hippocampal CA1 Region .

Degree: 2011, University of Otago

URL: http://hdl.handle.net/10523/1824

► Agmatine, a metabolite of L-arginine, is considered to be a novel putative neurotransmitter and has been implicated in spatial learning and memory processes. Agmatine-immunoreactivity has… (more)

▼ Agmatine, a metabolite of L-arginine, is considered to be a novel putative neurotransmitter and has been implicated in spatial learning and memory processes. Agmatine-immunoreactivity has been found in synaptic terminals of asymmetric excitatory synapses in the hippocampal CA1 region, which suggests that agmatine may be co-localized with glutamate, the primary excitatory neurotransmitter of hippocampal pyramidal cells. The first aim of the current project was to investigate if agmatine is co-localized with glutamate in the hippocampal pyramidal cells and within synaptic terminals at CA1 synapses, using immunofluorescence confocal microscopy and post-embedding electron microscopy-immunogold cytochemistry, respectively. Double immunofluorescence labelling indicated that agmatine and glutamate are co-localized in the majority of CA1-CA3 pyramidal cell bodies. Immunogold double labelling demonstrated that agmatine is also co-localized with glutamate in synaptic terminals in the CA1 stratum radiatum (SR) region. In the CA1 region of young male Sprague-Dawley rats, 97% of all agmatinergic profiles contained glutamate, and 92% of all glutamatergic profiles also contained agmatine (n = 6; 300 terminals). Having established co-localization of agmatine with glutamate within CA1 SR terminals, the second aim of the project was to investigate changes in co-localized agmatine and glutamate levels following 4 days Morris water maze training. The water maze trained rats (n = 3) showed significant increases in both agmatine and glutamate levels in the CA1 SR terminals (150 terminals; 78% increase in agmatine, p<0.01; ~41% increase in glutamate, p<0.05), compared to swim only control rats (n = 3; 150 terminals). The finding that water maze training induced increases in both agmatine and glutamate levels in the CA1 terminals, suggests that agmatine may play a role with glutamate in learning and memory processes. The final aim of the study was to examine possible spatial learning-induced structural changes at the postsynaptic site. The average thickness of the postsynaptic density at CA1 SR synapses (n = 240) was analysed. The water maze trained rats exhibited a 30% increase in their average postsynaptic density thickness (p < 0.001) compared to control rats. This suggests that there are alterations in the molecular components in the postsynaptic density following water maze training, which could lead to functional modifications of the postsynaptic neuron. Further studies are required to elucidate the molecular mechanisms by which agmatine may influence learning and memory processes, and to explore the functional significance of spatial learning induced increases in agmatine and glutamate levels and PSD thickness at CA1 SR synapses. Advisors/Committee Members: Leitch, Beulah (advisor).

Subjects/Keywords: Agmatine; Learning; Hippocampus

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Seo, S. (2011). Spatial Learning-Induced Changes at Agmatinergic and Glutamatergic Synapses in the Hippocampal CA1 Region . (Masters Thesis). University of Otago. Retrieved from http://hdl.handle.net/10523/1824

Chicago Manual of Style (16^th Edition):

Seo, Steve. “Spatial Learning-Induced Changes at Agmatinergic and Glutamatergic Synapses in the Hippocampal CA1 Region .” 2011. Masters Thesis, University of Otago. Accessed April 20, 2018. http://hdl.handle.net/10523/1824.

MLA Handbook (7^th Edition):

Seo, Steve. “Spatial Learning-Induced Changes at Agmatinergic and Glutamatergic Synapses in the Hippocampal CA1 Region .” 2011. Web. 20 Apr 2018.

Vancouver:

Seo S. Spatial Learning-Induced Changes at Agmatinergic and Glutamatergic Synapses in the Hippocampal CA1 Region . [Internet] [Masters thesis]. University of Otago; 2011. [cited 2018 Apr 20]. Available from: http://hdl.handle.net/10523/1824.

Council of Science Editors:

Seo S. Spatial Learning-Induced Changes at Agmatinergic and Glutamatergic Synapses in the Hippocampal CA1 Region . [Masters Thesis]. University of Otago; 2011. Available from: http://hdl.handle.net/10523/1824

University of Pennsylvania

14. Wang, Melissa Eveline. The Role of the Hippocampus in Representations of Emotional Memory.

Degree: 2013, University of Pennsylvania

URL: http://repository.upenn.edu/edissertations/940

► Although the hippocampus has long been implicated in contextual fear learning, the exact function of this brain structure is unclear. It is generally thought to… (more)

▼ Although the hippocampus has long been implicated in contextual fear learning, the exact function of this brain structure is unclear. It is generally thought to encode a spatial context with which a fear memory can be associated, but how it may accomplish this and whether it plays a role in emotional memory is largely unknown. It is also unclear whether the hippocampus acts as a single unitary structure, or whether the dorsal and ventral poles, which exhibit differential connectivity to other brain regions, function independently. This dissertation examines the involvement of the hippocampus in emotional learning. A contextual fear conditioning paradigm using a predator odor as an ethologically relevant fearful stimulus was developed and lesions and immunohistochemistry were used to examine differential involvement of the dorsal and ventral hippocampus in response to fear learning. Long-term physiological recordings of dorsal place cells were then conducted to determine the effects of fear conditioning and also fear extinction on contextual representations in the hippocampus. Additionally, cells in the ventral hippocampus were assessed for responses to visuospatial manipulations and changing odor cues of varying emotional valence. It was found that the dorsal and ventral hippocampal regions are both independently required for contextual fear conditioning, and neurons in each region are differentially activated in response to fear learning. Furthermore, place cells in the dorsal hippocampus remapped in response to fear conditioning and stabilized those new fields in the long term. Extinction training caused many place cells to remap once again, suggesting that the dorsal hippocampus encodes varying representations of `fearful' and `safe' contexts. Finally, cells in the ventral hippocampus exhibited stronger responses to anxiogenic contextual cues compared to dorsal cells. In conclusion, these data suggest that the hippocampus is involved in emotional learning and that its function may vary along its longitudinal axis.

Subjects/Keywords: context; dorsal hippocampus; emotion; fear conditioning; hippocampus; ventral hippocampus; Neuroscience and Neurobiology

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Wang, M. E. (2013). The Role of the Hippocampus in Representations of Emotional Memory. (Thesis). University of Pennsylvania. Retrieved from http://repository.upenn.edu/edissertations/940

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Wang, Melissa Eveline. “The Role of the Hippocampus in Representations of Emotional Memory.” 2013. Thesis, University of Pennsylvania. Accessed April 20, 2018. http://repository.upenn.edu/edissertations/940.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Wang, Melissa Eveline. “The Role of the Hippocampus in Representations of Emotional Memory.” 2013. Web. 20 Apr 2018.

Vancouver:

Wang ME. The Role of the Hippocampus in Representations of Emotional Memory. [Internet] [Thesis]. University of Pennsylvania; 2013. [cited 2018 Apr 20]. Available from: http://repository.upenn.edu/edissertations/940.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Wang ME. The Role of the Hippocampus in Representations of Emotional Memory. [Thesis]. University of Pennsylvania; 2013. Available from: http://repository.upenn.edu/edissertations/940

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Dalhousie University

15. McClelland, Christine R. Cux2 regulates neurogenesis in the postnatal mouse hippocampus.

Degree: MS, Department of Anatomy & Neurobiolgy with Neuroscience, 2012, Dalhousie University

URL: http://hdl.handle.net/10222/15237

► Although once thought to be incapable of regeneration, the adult mammalian brain generates new neurons in two regions: the SVZ of the lateral ventricle and… (more)

Subjects/Keywords: Hippocampus; Cux2; adult neurogenesis

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

McClelland, C. R. (2012). Cux2 regulates neurogenesis in the postnatal mouse hippocampus. (Masters Thesis). Dalhousie University. Retrieved from http://hdl.handle.net/10222/15237

Chicago Manual of Style (16^th Edition):

McClelland, Christine R. “Cux2 regulates neurogenesis in the postnatal mouse hippocampus.” 2012. Masters Thesis, Dalhousie University. Accessed April 20, 2018. http://hdl.handle.net/10222/15237.

MLA Handbook (7^th Edition):

McClelland, Christine R. “Cux2 regulates neurogenesis in the postnatal mouse hippocampus.” 2012. Web. 20 Apr 2018.

Vancouver:

McClelland CR. Cux2 regulates neurogenesis in the postnatal mouse hippocampus. [Internet] [Masters thesis]. Dalhousie University; 2012. [cited 2018 Apr 20]. Available from: http://hdl.handle.net/10222/15237.

Council of Science Editors:

McClelland CR. Cux2 regulates neurogenesis in the postnatal mouse hippocampus. [Masters Thesis]. Dalhousie University; 2012. Available from: http://hdl.handle.net/10222/15237

16. Koutsona, Christina. Επίδραση των οπιοειδών στη δραστηριότητα των νευρώνων του ιπποκάμπου.

Degree: 2014, University of Thessaly (UTH); Πανεπιστήμιο Θεσσαλίας

URL: http://hdl.handle.net/10442/hedi/35901

►

The extended research in the structural and functional features of the hippocampus has revealed the differentiation of the dorsal and the ventral hippocampus in terms… (more)

▼

The extended research in the structural and functional features of the hippocampus has revealed the differentiation of the dorsal and the ventral hippocampus in terms of electrophysiological characteristics of the principal neurons, anatomical characteristics of the network and differential role of the neurotransmitters and neuromodulators, including the opioids. Aim of the present study was to investigate the role of the Ih current of the CA1 interneurons in the functional differentiation of the dorsal and the ventral hippocampus and to examine the effect of morphine on this current under current clamp conditions.Intracellular recordings were obtained in vitro from CA1 interneurons of the oriens/alveus border and pyramidal neurons. The interneurons were recognized as such according to electrophysiological criteria. The passive membrane properties of the interneurons of the dorsal and the ventral hippocampus were similar. The response of the interneurons to a sustained hyperpolarizing electrical pulse was different in the dorsal and the ventral hippocampus. The interneurons of the ventral hippocampus showed a stronger hyperpolarization in response to a current pulse of given intensity compared to the interneurons of the dorsal hippocampus, the kinetics of the Ih current seamed to be different and the characteristics of the rebound depolarization were distinct between the two populations. Morphine (30 μΜ) reduced the activation of the Ih current, hyperpolarized the interneurons and changed the characteristics of the rebound depolarization. In one interneuron the drug caused a depolarization of the resting membrane potential and an augmentation of the Ih current. Moreover, morphine decreased the frequency of the spontaneous action potentials at resting membrane potential of the interneurons and the number of the action potentials elicited by a sustained depolarizing pulse.These findings substantiate the hypothesis that the interneurons of the dorsal and the ventral hippocampus may be intrinsically different. Furthermore, they confirm the complexity of the modulatory role of the opioids in the network of the hippocampus and extend the already existing evidence that opioids can reduce the excitability of the interneurons of the dorsal and the ventral hippocampus.

Η διερεύνηση των ανατομικών δομών και των λειτουργιών του ιπποκάμπου έχει αναδείξει τη διαφοροποίηση της κοιλιακής και της ραχιαίας μοίρας του. Διαφορές βρέθηκαν σε επίπεδο λειτουργίας πυραμιδικών νευρώνων και νευρωνικών κυκλωμάτων, καθώς και σε επίπεδο δράσης νευροδιαβιβαστών και νευρορυθμιστών, μεταξύ των οποίων τα οπιοειδή. Σκοπός της παρούσης εργασίας ήταν η διερεύνηση του ρόλου του ρεύματος Ιh των ενδονευρώνων της CA1 περιοχής στη διαφοροποίηση του κοιλιακού και ραχιαίου ιπποκάμπου και της δράσης των οπιοειδών στο ρεύμα αυτό σε συνθήκες καθήλωσης ρεύματος.Διενεργήθηκαν ενδοκυττάριες in vitro καταγραφές με αιχμηρό ηλεκτρόδιο από ενδονευρώνες του ορίου σκάφης/στιβάδας πολυμόρφων κυττάρων και από πυραμιδικούς νευρώνες της CA1 περιοχής. Οι ενδονευρώνες…

Subjects/Keywords: Οπιοειδή; Ιππόκαμπος; Opioids; Hippocampus

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Koutsona, C. (2014). Επίδραση των οπιοειδών στη δραστηριότητα των νευρώνων του ιπποκάμπου. (Thesis). University of Thessaly (UTH); Πανεπιστήμιο Θεσσαλίας. Retrieved from http://hdl.handle.net/10442/hedi/35901

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Koutsona, Christina. “Επίδραση των οπιοειδών στη δραστηριότητα των νευρώνων του ιπποκάμπου.” 2014. Thesis, University of Thessaly (UTH); Πανεπιστήμιο Θεσσαλίας. Accessed April 20, 2018. http://hdl.handle.net/10442/hedi/35901.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Koutsona, Christina. “Επίδραση των οπιοειδών στη δραστηριότητα των νευρώνων του ιπποκάμπου.” 2014. Web. 20 Apr 2018.

Vancouver:

Koutsona C. Επίδραση των οπιοειδών στη δραστηριότητα των νευρώνων του ιπποκάμπου. [Internet] [Thesis]. University of Thessaly (UTH); Πανεπιστήμιο Θεσσαλίας; 2014. [cited 2018 Apr 20]. Available from: http://hdl.handle.net/10442/hedi/35901.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Koutsona C. Επίδραση των οπιοειδών στη δραστηριότητα των νευρώνων του ιπποκάμπου. [Thesis]. University of Thessaly (UTH); Πανεπιστήμιο Θεσσαλίας; 2014. Available from: http://hdl.handle.net/10442/hedi/35901

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of British Columbia

17. Van der Kooy, Derek. Monoamine involvement in hippocampal self-stimulation .

Degree: 1977, University of British Columbia

URL: http://hdl.handle.net/2429/20598

► The roles of the noradrenergic and serotonergic innervations of the hippocampus were investigated with respect to their involvement in the intracranial self-stimulation of this structure.… (more)

Subjects/Keywords: Amines; Hippocampus

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Van der Kooy, D. (1977). Monoamine involvement in hippocampal self-stimulation . (Thesis). University of British Columbia. Retrieved from http://hdl.handle.net/2429/20598

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Van der Kooy, Derek. “Monoamine involvement in hippocampal self-stimulation .” 1977. Thesis, University of British Columbia. Accessed April 20, 2018. http://hdl.handle.net/2429/20598.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Van der Kooy, Derek. “Monoamine involvement in hippocampal self-stimulation .” 1977. Web. 20 Apr 2018.

Vancouver:

Van der Kooy D. Monoamine involvement in hippocampal self-stimulation . [Internet] [Thesis]. University of British Columbia; 1977. [cited 2018 Apr 20]. Available from: http://hdl.handle.net/2429/20598.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Van der Kooy D. Monoamine involvement in hippocampal self-stimulation . [Thesis]. University of British Columbia; 1977. Available from: http://hdl.handle.net/2429/20598

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of South Florida

18. Daily, Jennifer L. Efficacy of Increased Ube3a Protein Levels in the Brain in Rescuing the Phenotype of an Angelman Syndrome Mouse.

Degree: 2012, University of South Florida

URL: http://scholarcommons.usf.edu/etd/4305

► Angelman syndrome (AS), a genetic disorder occurring in approximately one in every 15,000 births, is characterized by severe mental retardation, seizures, difficulty speaking and ataxia.… (more)

Subjects/Keywords: Angelman; hippocampus; proteasome; UBE3A; Neurosciences

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Daily, J. L. (2012). Efficacy of Increased Ube3a Protein Levels in the Brain in Rescuing the Phenotype of an Angelman Syndrome Mouse. (Thesis). University of South Florida. Retrieved from http://scholarcommons.usf.edu/etd/4305

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Daily, Jennifer L. “Efficacy of Increased Ube3a Protein Levels in the Brain in Rescuing the Phenotype of an Angelman Syndrome Mouse.” 2012. Thesis, University of South Florida. Accessed April 20, 2018. http://scholarcommons.usf.edu/etd/4305.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Daily, Jennifer L. “Efficacy of Increased Ube3a Protein Levels in the Brain in Rescuing the Phenotype of an Angelman Syndrome Mouse.” 2012. Web. 20 Apr 2018.

Vancouver:

Daily JL. Efficacy of Increased Ube3a Protein Levels in the Brain in Rescuing the Phenotype of an Angelman Syndrome Mouse. [Internet] [Thesis]. University of South Florida; 2012. [cited 2018 Apr 20]. Available from: http://scholarcommons.usf.edu/etd/4305.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Daily JL. Efficacy of Increased Ube3a Protein Levels in the Brain in Rescuing the Phenotype of an Angelman Syndrome Mouse. [Thesis]. University of South Florida; 2012. Available from: http://scholarcommons.usf.edu/etd/4305

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Alberta

19. Sharma, Arjun V. Neurosilence: intracerebral applications of protein synthesis inhibitors eliminate neural activity.

Degree: MS, Department of Psychology, 2010, University of Alberta

URL: https://era.library.ualberta.ca/files/47429b262

► The acquisition of a behavioural response (learning) and the later retrieval of this response (memory) are separated by an endogenous biological process which consolidates the… (more)

Subjects/Keywords: memory; cycloheximide; EEG; anisomycin; hippocampus

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Sharma, A. V. (2010). Neurosilence: intracerebral applications of protein synthesis inhibitors eliminate neural activity. (Masters Thesis). University of Alberta. Retrieved from https://era.library.ualberta.ca/files/47429b262

Chicago Manual of Style (16^th Edition):

Sharma, Arjun V. “Neurosilence: intracerebral applications of protein synthesis inhibitors eliminate neural activity.” 2010. Masters Thesis, University of Alberta. Accessed April 20, 2018. https://era.library.ualberta.ca/files/47429b262.

MLA Handbook (7^th Edition):

Sharma, Arjun V. “Neurosilence: intracerebral applications of protein synthesis inhibitors eliminate neural activity.” 2010. Web. 20 Apr 2018.

Vancouver:

Sharma AV. Neurosilence: intracerebral applications of protein synthesis inhibitors eliminate neural activity. [Internet] [Masters thesis]. University of Alberta; 2010. [cited 2018 Apr 20]. Available from: https://era.library.ualberta.ca/files/47429b262.

Council of Science Editors:

Sharma AV. Neurosilence: intracerebral applications of protein synthesis inhibitors eliminate neural activity. [Masters Thesis]. University of Alberta; 2010. Available from: https://era.library.ualberta.ca/files/47429b262

University of Florida

20. Astary, Garrett W. Mr-Guided Real-Time Convection-Enhanced Delivery.

Degree: Biomedical Engineering, 2011, University of Florida

URL: http://ufdc.ufl.edu/UFE0043695

► Convection-enhanced delivery (CED) is a drug delivery method characterized by direct infusion into target tissues under a positive pressure gradient and shows promise for treating… (more)

Subjects/Keywords: ced – hippocampus – mri; Biomedical Engineering

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Astary, G. W. (2011). Mr-Guided Real-Time Convection-Enhanced Delivery. (Doctoral Dissertation). University of Florida. Retrieved from http://ufdc.ufl.edu/UFE0043695

Chicago Manual of Style (16^th Edition):

Astary, Garrett W. “Mr-Guided Real-Time Convection-Enhanced Delivery.” 2011. Doctoral Dissertation, University of Florida. Accessed April 20, 2018. http://ufdc.ufl.edu/UFE0043695.

MLA Handbook (7^th Edition):

Astary, Garrett W. “Mr-Guided Real-Time Convection-Enhanced Delivery.” 2011. Web. 20 Apr 2018.

Vancouver:

Astary GW. Mr-Guided Real-Time Convection-Enhanced Delivery. [Internet] [Doctoral dissertation]. University of Florida; 2011. [cited 2018 Apr 20]. Available from: http://ufdc.ufl.edu/UFE0043695.

Council of Science Editors:

Astary GW. Mr-Guided Real-Time Convection-Enhanced Delivery. [Doctoral Dissertation]. University of Florida; 2011. Available from: http://ufdc.ufl.edu/UFE0043695

University of Florida

21. Stanley, David A. Hippocampal Circadian Rhythms in Temporal Lobe Epilepsy.

Degree: Biomedical Engineering, 2013, University of Florida

URL: http://ufdc.ufl.edu/UFE0045234

► For over a century epileptic seizures have been known to cluster at specific times of the day. Recent studies have suggested that the circadian regulatory… (more)

▼ For over a century epileptic seizures have been known to cluster at specific times of the day. Recent studies have suggested that the circadian regulatory system may become permanently altered in epilepsy, but little is known about how this affects neural activity and the daily patterns of seizure recurrence. To investigate, we tracked long-term changes in the rate of spontaneous hippocampal EEG spikes (SPKs) in a rat model of temporal lobe epilepsy. In healthy animals, SPKs oscillated with near 24-hour period; however, following injury by status epilepticus (SE), a persistent phase shift of approximately 12 hours emerged in animals that later went on to develop chronic spontaneous seizures. Additional measurements showed that this phase shift affected other features of hippocampal activity, including 24-hour modulation of gamma- and beta-frequency rhythms, but did not affect global 24-hour rhythms, including core body temperature and theta state transitions. Based on this, we hypothesized that the phase shift might be due to locally impaired circadian input to the hippocampus. This was investigated using a biophysical computer model in which we showed that subtle changes in the relative strengths of circadian inputs could produce a phase shift in hippocampal neural activity. Additional EEG analysis provided evidence for altered circadian input strengths by showing that the amplitude of 24-hour modulation of certain EEG rhythms, particularly hippocampal theta, was attenuated following SE injury. Furthermore, MRI provided evidence that the medial septum, a putative circadian relay center, exhibited signs of damage and therefore could contribute to local circadian impairment. Our results suggest that balanced circadian input is critical to maintaining natural circadian phase in the hippocampus, and that damage to the medial septum may disrupt this balance. ( en ) Advisors/Committee Members: Carney, Paul Richard (committee chair), Harris, John Gregory (committee member), Khargonekar, Pramod P (committee member).

Subjects/Keywords: circadian – epilepsy – hippocampus; Biomedical Engineering

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Stanley, D. A. (2013). Hippocampal Circadian Rhythms in Temporal Lobe Epilepsy. (Doctoral Dissertation). University of Florida. Retrieved from http://ufdc.ufl.edu/UFE0045234

Chicago Manual of Style (16^th Edition):

Stanley, David A. “Hippocampal Circadian Rhythms in Temporal Lobe Epilepsy.” 2013. Doctoral Dissertation, University of Florida. Accessed April 20, 2018. http://ufdc.ufl.edu/UFE0045234.

MLA Handbook (7^th Edition):

Stanley, David A. “Hippocampal Circadian Rhythms in Temporal Lobe Epilepsy.” 2013. Web. 20 Apr 2018.

Vancouver:

Stanley DA. Hippocampal Circadian Rhythms in Temporal Lobe Epilepsy. [Internet] [Doctoral dissertation]. University of Florida; 2013. [cited 2018 Apr 20]. Available from: http://ufdc.ufl.edu/UFE0045234.

Council of Science Editors:

Stanley DA. Hippocampal Circadian Rhythms in Temporal Lobe Epilepsy. [Doctoral Dissertation]. University of Florida; 2013. Available from: http://ufdc.ufl.edu/UFE0045234

University of Aberdeen

22. Stoney, Patrick Niall. The roles of Pax6 in neural precursor migration and axon guidance.

Degree: 2009, University of Aberdeen

URL: http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=92509 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.521239

► The ability of migrating neurons and growth cones to navigate through their environment is crucial for the correct development of the brain. Cells and growth… (more)

▼ The ability of migrating neurons and growth cones to navigate through their environment is crucial for the correct development of the brain. Cells and growth cones may be guided by electrical, chemical or topographical cues in their environment. Pax6 is a transcription factor vital for brain development. Pax6-/- mutant mice die perinatally with defects in neuronal proliferation and differentiation, cortical cell migration and axon guidance, yet it is not clear which guidance cues Pax6-/- mutant neurons fail to interpret. Dissociated cultured cells were used to study the cell-autonomous effects of Pax6 mutation on guidance of growth cones and migrating neural precursors by environmental cues. Neurites from mouse embryonic cortical neurons aligned perpendicular to 1 μm-wide, 130 nm-deep substratum grooves. Pax6-/- mutation abolished contact-mediated neurite guidance by these grooves. Laminin induced a switch from perpendicular to parallel alignment to grooves, via a β1 integrin-independent mechanism. Blocking cAMP signalling abolished perpendicular alignment to polylysine-coated grooves, but enhanced parallel alignment to laminin-coated grooves. Pax6 null mutation or overexpression also caused specific defects in contact-guided migration by cortical cells. An electric field applied to E16.5 cortical neurons increased the frequency of extension of neurites aligned perpendicular to the field axis. Pax6-/- mutant cells responded to an electric field with reduced anodal extension, but no significant increase in perpendicular neurite extension. Electrical cues were prioritised over topographical cues when presented in combination. Taken together, data suggest that Pax6 mutant cortical cells do not completely lack the ability to detect extracellular guidance cues, but they respond differently to wild-type cells. In combination with other defects identified in the cortex, this may contribute to the cell migration and axon guidance phenotypes in the brain of the Pax6-/- embryo. This study also identified novel Pax6 expression in the trigeminal ganglion, where it may regulate axon guidance and neurogenesis.

Subjects/Keywords: 573.8; Brain : Neurons : Hippocampus

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Stoney, P. N. (2009). The roles of Pax6 in neural precursor migration and axon guidance. (Doctoral Dissertation). University of Aberdeen. Retrieved from http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=92509 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.521239

Chicago Manual of Style (16^th Edition):

Stoney, Patrick Niall. “The roles of Pax6 in neural precursor migration and axon guidance.” 2009. Doctoral Dissertation, University of Aberdeen. Accessed April 20, 2018. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=92509 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.521239.

MLA Handbook (7^th Edition):

Stoney, Patrick Niall. “The roles of Pax6 in neural precursor migration and axon guidance.” 2009. Web. 20 Apr 2018.

Vancouver:

Stoney PN. The roles of Pax6 in neural precursor migration and axon guidance. [Internet] [Doctoral dissertation]. University of Aberdeen; 2009. [cited 2018 Apr 20]. Available from: http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=92509 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.521239.

Council of Science Editors:

Stoney PN. The roles of Pax6 in neural precursor migration and axon guidance. [Doctoral Dissertation]. University of Aberdeen; 2009. Available from: http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=92509 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.521239

University of Edinburgh

23. Langston, Rosamund Fay. Role of the hippocampus in event memory in the rat.

Degree: 2008, University of Edinburgh

URL: http://hdl.handle.net/1842/4141

► This thesis aims to examine the role of the hippocampus in declarative memory through the development of animal behavioural models of episodic memory for laboratory… (more)

▼ This thesis aims to examine the role of the hippocampus in declarative memory through the development of animal behavioural models of episodic memory for laboratory rats. Episodic memory- memory for unique events or episodes- is part of the declarative memory system thought to be mediated by the medial temporal lobe area of the brain in humans. One commonly used test of episodic memory in human subjects is paired associate learning. The first part of this thesis describes the adaptation of this human test for use with laboratory rats. Using their natural foraging tendency, rats were trained to search for different flavours of food at different locations within a large enclosure. When cued with a piece of food of a particular flavour in a separate box, rats learned to return to the place where that flavour of food had previously been found. This paradigm was used to investigate the role of the hippocampus in paired-associate learning using temporary pharmacological inactivation and permanent neurotoxic lesion techniques. The hippocampus has also been strongly implicated in spatial navigation, learning and memory in rats and humans. In the experiments described previously, attempts were therefore made to demonstrate that the results were not confounded by a simple deficit in spatial navigation. An alternative approach to studying episodic memory in the laboratory rat is to use the criteria established by Tulving in 1972 to describe episodic memory. He stated that episodic memory should encompass the memory for an event and the spatiotemporal context in which it occurred, i.e. the ”what”, ”where” and ”when” of an event. He later updated these criteria to include demonstration of autonoetic consciousness- most easily described as a sense of self awareness. Since this is difficult or impossible to demonstrate in animals, the term ”episodic-like” memory was coined (Clayton & Dickinson 1998) to describe the flexible use of information about the spatiotemporal aspects of an event by non-human species. Since it has been difficult to demonstrate the use of time (when) in rats (Bird et al; 2003, Babb & Crystal 2006a), Eacott & Norman (2004) suggested that the ”when” component could be replaced by context; i.e. another element specific to a particular event that they labelled ”which”. The next part of this thesis describes the use of the task published by Eacott & Norman to test episodic-like memory in the laboratory rat. Using the innate spontaneous behaviour of rats to explore novel aspects of their environment, they were exposed to multiple unique events. These consisted of various three-dimensional objects being presented in different locations within different contexts. Their memory for manipulations of the environment was then tested by presenting them with an event in which one combination of object, location and context was different from combinations which had previously been encountered. Due to their tendency to explore novel aspects of their environment, normal rats spent the majority of their time exploring the…

Subjects/Keywords: 612.8; rat; hippocampus; episodic memory

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Langston, R. F. (2008). Role of the hippocampus in event memory in the rat. (Doctoral Dissertation). University of Edinburgh. Retrieved from http://hdl.handle.net/1842/4141

Chicago Manual of Style (16^th Edition):

Langston, Rosamund Fay. “Role of the hippocampus in event memory in the rat.” 2008. Doctoral Dissertation, University of Edinburgh. Accessed April 20, 2018. http://hdl.handle.net/1842/4141.

MLA Handbook (7^th Edition):

Langston, Rosamund Fay. “Role of the hippocampus in event memory in the rat.” 2008. Web. 20 Apr 2018.

Vancouver:

Langston RF. Role of the hippocampus in event memory in the rat. [Internet] [Doctoral dissertation]. University of Edinburgh; 2008. [cited 2018 Apr 20]. Available from: http://hdl.handle.net/1842/4141.

Council of Science Editors:

Langston RF. Role of the hippocampus in event memory in the rat. [Doctoral Dissertation]. University of Edinburgh; 2008. Available from: http://hdl.handle.net/1842/4141

University of Edinburgh

24. Jordan, Graeme R. Investigation of the functional effects of two novel ampakines in the CNS.

Degree: 2007, University of Edinburgh

URL: http://hdl.handle.net/1842/1946

► The ionotropic glutamate AMPA ((R,S)-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) receptor mediates the majority of excitatory transmission in the CNS. AMPA receptors play a crucial role in both basal… (more)

▼ The ionotropic glutamate AMPA ((R,S)-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) receptor mediates the majority of excitatory transmission in the CNS. AMPA receptors play a crucial role in both basal neurotransmission and synaptic plasticity events (such as long-term potentiation, LTP). Compounds that ‘potentiate’ AMPA receptor function (‘Ampakines’) are known to positively modulate glutamatergic AMPA receptor-gated currents, by slowing the deactivation and desensitisation rate of the receptors, in the presence of the endogenous agonist glutamate. Ampakines have been shown to facilitate LTP induction, improve cognition, and as such have potential in the treatment of conditions such as depression and psychoses (schizophrenia). The main aim of this thesis was to investigate the functional actions of two novel Ampakines, Org 26576 and Org 24448, in the mouse brain. The studies described in this thesis were designed to address this and are outlined as follows: 1. Characterisation and validation of an in vivo semi-quantitative model of [14C]-2-deoxyglucose autoradiography in the C57Bl/6J mouse The first study sought to develop and characterise a model of [14C]-2-deoxyglucose autoradiography, to allow measurement of regional alterations in local cerebral glucose use (LCGU) in the mouse CNS. Following intraperitoneal injection of [14C]-2-deoxyglucose in C57Bl/6J mice, the radiolabelled brains were sectioned and exposed to x-ray film. The resultant autoradiograms were semi-quantitatively analysed for relative optical densities in predetermined regions of interest. The baseline LCGU values in different brain regions were found to be consistent with previously published data. The model was also able to replicate the effects of a well-characterised compound, the NMDA receptor antagonist MK-801 (0.5 mg/kg), in respect to functional cerebral changes. Characteristic effects such as prominent increases in LCGU in the limbic system, and decreases in the somatosensory cortex were reproduced in the model. Thus the semi-quantitative [14C]-2-deoxyglucose model was reproducible and accurate and thus could be further used to investigate the effects of the novel Ampakines, Org 26576 and Org 24448, on cerebral function. 2. Investigation into the effects of acute administration of the novel Ampakines Org 26576 and Org 24448 on functional activity in the murine cerebrum Following the establishment of the methodology, regional alterations in LCGU in response to the Ampakines Org 26576 and Org 24448 were investigated using [14C]-2-deoxyglucose autoradiography. Both Org 26576 and Org 24448 produced regionally selective, dose-dependent increases in LCGU in the mouse cerebrum when administered acutely (~1 hr). The compounds displayed similar yet functionally distinct profiles of activation, the highest levels of activation occurred in areas of the limbic system (hippocampus), sensory systems, and various nuclei (raphe nucleus). Their effects were blocked by pre-administration of the potent selective AMPA receptor antagonist, NBQX (10…

Subjects/Keywords: 615.1; cognition; depression; schizophrenia; hippocampus

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Jordan, G. R. (2007). Investigation of the functional effects of two novel ampakines in the CNS. (Doctoral Dissertation). University of Edinburgh. Retrieved from http://hdl.handle.net/1842/1946

Chicago Manual of Style (16^th Edition):

Jordan, Graeme R. “Investigation of the functional effects of two novel ampakines in the CNS.” 2007. Doctoral Dissertation, University of Edinburgh. Accessed April 20, 2018. http://hdl.handle.net/1842/1946.

MLA Handbook (7^th Edition):

Jordan, Graeme R. “Investigation of the functional effects of two novel ampakines in the CNS.” 2007. Web. 20 Apr 2018.

Vancouver:

Jordan GR. Investigation of the functional effects of two novel ampakines in the CNS. [Internet] [Doctoral dissertation]. University of Edinburgh; 2007. [cited 2018 Apr 20]. Available from: http://hdl.handle.net/1842/1946.

Council of Science Editors:

Jordan GR. Investigation of the functional effects of two novel ampakines in the CNS. [Doctoral Dissertation]. University of Edinburgh; 2007. Available from: http://hdl.handle.net/1842/1946

University of Aberdeen

25. Godman, Timothy Hugh. The functional role of retinoic acid in the regulation of cell proliferation in the adult hippocampus.

Degree: PhD, 2010, University of Aberdeen

URL: http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=167035 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.542630

► Levels of retinoic acid (RA), the active metabolite of vitamin A, are tightly regulated throughout vertebrate CNS development by RA synthesising and catabolising enzymes. However,… (more)

Subjects/Keywords: 612.8; Hippocampus (Brain); Cell proliferation

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Godman, T. H. (2010). The functional role of retinoic acid in the regulation of cell proliferation in the adult hippocampus. (Doctoral Dissertation). University of Aberdeen. Retrieved from http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=167035 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.542630

Chicago Manual of Style (16^th Edition):

Godman, Timothy Hugh. “The functional role of retinoic acid in the regulation of cell proliferation in the adult hippocampus.” 2010. Doctoral Dissertation, University of Aberdeen. Accessed April 20, 2018. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=167035 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.542630.

MLA Handbook (7^th Edition):

Godman, Timothy Hugh. “The functional role of retinoic acid in the regulation of cell proliferation in the adult hippocampus.” 2010. Web. 20 Apr 2018.

Vancouver:

Godman TH. The functional role of retinoic acid in the regulation of cell proliferation in the adult hippocampus. [Internet] [Doctoral dissertation]. University of Aberdeen; 2010. [cited 2018 Apr 20]. Available from: http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=167035 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.542630.

Council of Science Editors:

Godman TH. The functional role of retinoic acid in the regulation of cell proliferation in the adult hippocampus. [Doctoral Dissertation]. University of Aberdeen; 2010. Available from: http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=167035 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.542630

Ruhr Universität Bochum

26. Abdulazim, Amr Nabil. Funktionelle Untersuchungen zur Rolle von Pannexin 1 in der hippocampalen Neuroplastizität.

Degree: 2014, Ruhr Universität Bochum

URL: http://nbn-resolving.de/urn/resolver.pl?urn=urn:nbn:de:hbz:294-42429

► Pannexin 1 (Panx1) sind integrale Membranproteine, die Membrankanäle mit sehr hoher Leitfähigkeit (550 pS) bilden. Neben der Beteiligung an pathophysiologischen Prozessen, wie Inflammation oder Ischämie,… (more)

Subjects/Keywords: Gedächtnis; Hippocampus; Langzeitpotenzierung; Lernen; Synapse

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Abdulazim, A. N. (2014). Funktionelle Untersuchungen zur Rolle von Pannexin 1 in der hippocampalen Neuroplastizität. (Thesis). Ruhr Universität Bochum. Retrieved from http://nbn-resolving.de/urn/resolver.pl?urn=urn:nbn:de:hbz:294-42429

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Abdulazim, Amr Nabil. “Funktionelle Untersuchungen zur Rolle von Pannexin 1 in der hippocampalen Neuroplastizität.” 2014. Thesis, Ruhr Universität Bochum. Accessed April 20, 2018. http://nbn-resolving.de/urn/resolver.pl?urn=urn:nbn:de:hbz:294-42429.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Abdulazim, Amr Nabil. “Funktionelle Untersuchungen zur Rolle von Pannexin 1 in der hippocampalen Neuroplastizität.” 2014. Web. 20 Apr 2018.

Vancouver:

Abdulazim AN. Funktionelle Untersuchungen zur Rolle von Pannexin 1 in der hippocampalen Neuroplastizität. [Internet] [Thesis]. Ruhr Universität Bochum; 2014. [cited 2018 Apr 20]. Available from: http://nbn-resolving.de/urn/resolver.pl?urn=urn:nbn:de:hbz:294-42429.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Abdulazim AN. Funktionelle Untersuchungen zur Rolle von Pannexin 1 in der hippocampalen Neuroplastizität. [Thesis]. Ruhr Universität Bochum; 2014. Available from: http://nbn-resolving.de/urn/resolver.pl?urn=urn:nbn:de:hbz:294-42429

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Ruhr Universität Bochum

27. Popkirov, Stoyan Georgiev. Synaptische Plastizität im Hippocampus : die Rolle des metabotropen Glutamatrezeptors Subtyp 5 bei der Langzeit- Depression an der CA1-Synapse und beim hippokampalen Lernen.

Degree: 2014, Ruhr Universität Bochum

URL: http://nbn-resolving.de/urn/resolver.pl?urn=urn:nbn:de:hbz:294-42607

► Am Tiermodell der sich frei verhaltenden Ratte konnten wir mittels niederfrequenter Stimulation der Schaffer- Kollateralen Kurzzeit- und Langzeit-Depression der Potentialantwort in der Hippocampus-Region CA1 induzieren.… (more)

Subjects/Keywords: Neurophysiologie; Lernen; Gedächtnis; Hippocampus; Depression

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Popkirov, S. G. (2014). Synaptische Plastizität im Hippocampus : die Rolle des metabotropen Glutamatrezeptors Subtyp 5 bei der Langzeit- Depression an der CA1-Synapse und beim hippokampalen Lernen. (Thesis). Ruhr Universität Bochum. Retrieved from http://nbn-resolving.de/urn/resolver.pl?urn=urn:nbn:de:hbz:294-42607

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Popkirov, Stoyan Georgiev. “Synaptische Plastizität im Hippocampus : die Rolle des metabotropen Glutamatrezeptors Subtyp 5 bei der Langzeit- Depression an der CA1-Synapse und beim hippokampalen Lernen.” 2014. Thesis, Ruhr Universität Bochum. Accessed April 20, 2018. http://nbn-resolving.de/urn/resolver.pl?urn=urn:nbn:de:hbz:294-42607.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Popkirov, Stoyan Georgiev. “Synaptische Plastizität im Hippocampus : die Rolle des metabotropen Glutamatrezeptors Subtyp 5 bei der Langzeit- Depression an der CA1-Synapse und beim hippokampalen Lernen.” 2014. Web. 20 Apr 2018.

Vancouver:

Popkirov SG. Synaptische Plastizität im Hippocampus : die Rolle des metabotropen Glutamatrezeptors Subtyp 5 bei der Langzeit- Depression an der CA1-Synapse und beim hippokampalen Lernen. [Internet] [Thesis]. Ruhr Universität Bochum; 2014. [cited 2018 Apr 20]. Available from: http://nbn-resolving.de/urn/resolver.pl?urn=urn:nbn:de:hbz:294-42607.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Popkirov SG. Synaptische Plastizität im Hippocampus : die Rolle des metabotropen Glutamatrezeptors Subtyp 5 bei der Langzeit- Depression an der CA1-Synapse und beim hippokampalen Lernen. [Thesis]. Ruhr Universität Bochum; 2014. Available from: http://nbn-resolving.de/urn/resolver.pl?urn=urn:nbn:de:hbz:294-42607

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Southern California

28. Hsiao, Min-Chi. Developing a neural prosthesis for hippocampus: proof-of-concept using the in vitro slice.

Degree: PhD, Biomedical Engineering, 2009, University of Southern California

URL: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll127/id/236331/rec/1895

► We are developing a neural prosthesis that can replace regions of the hippocampal brain area that have been damaged by disease or insult. We used… (more)

▼ We are developing a neural prosthesis that can replace regions of the hippocampal brain area that have been damaged by disease or insult. We used the hippocampal slice preparation as the first step in developing such a prosthesis. The major intrinsic circuitry of the hippocampus consists of an excitatory cascade involving the dentate gyrus (DG), CA3, and CA1 subregions; it can be maintained in a transverse slice preparation. Our goal is to develop a biologically realistic model to replace the CA3 region; as such the model transforms DG signals into the corresponding output signals, reinstating the activity in CA1 region. The path to proof our concept involves: i) developing a slice-prosthesis interface specifically for the trisynaptic pathway, ii) formulating nonlinear neuronal models of the hippocampal trans-synaptic transformation, and iii) designing experimental paradigms to validate our prosthesis model.; In this thesis, a conformal multi-electrode array that spatially matched with the trisynaptic pathway was fabricated and used as the slice-prosthesis interface. The recorded data were used to characterize the hippocampal nonlinear properties using Laguerre-Volterra kernel modeling approach. Two experimental paradigms were developed to validate our in vitro prosthesis model. The first paradigm explicitly replaced CA3 computational function. A CA3 model was built to predict CA3 output based on DG input, and was further implemented into a VLSI device. In the replacement experiment, DG signals transmitted to the VLSI-CA3 model. Output from the VLSI device, which represents the equivalent responses from the CA3, provided the activation of synaptic inputs to the CA1. Results show the propagation of patterns of activity from DG-VLSI-CA1 reproduces the activity observed in DG-CA3-CA1 circuitry.; The second experimental paradigm was developed to optimize our first prosthesis model; it directly controlled CA1 dynamics. A DG-CA1 trajectory model and a CA1 plant model were built, and an inverse CA1 plant model was formulated. The desired CA1 output was first predicted by the DG-CA1 trajectory model and then converted to the desired stimulation through an inverse CA1 plant model. The derived desired stimuli were used to evoke CA1 activity. Results show improved accuracy in CA1 responses using this modeling-control paradigm. Advisors/Committee Members: Berger, Theodore W. (Committee Chair), Song, Dong (Committee Member), Baudry, Michel (Committee Member), D'Argenio, David Z. (Committee Member), Swanson, Larry W. (Committee Member).

Subjects/Keywords: nerual prosthesis; hippocampus; Volterra kernel

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Hsiao, M. (2009). Developing a neural prosthesis for hippocampus: proof-of-concept using the in vitro slice. (Doctoral Dissertation). University of Southern California. Retrieved from http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll127/id/236331/rec/1895

Chicago Manual of Style (16^th Edition):

Hsiao, Min-Chi. “Developing a neural prosthesis for hippocampus: proof-of-concept using the in vitro slice.” 2009. Doctoral Dissertation, University of Southern California. Accessed April 20, 2018. http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll127/id/236331/rec/1895.

MLA Handbook (7^th Edition):

Hsiao, Min-Chi. “Developing a neural prosthesis for hippocampus: proof-of-concept using the in vitro slice.” 2009. Web. 20 Apr 2018.

Vancouver:

Hsiao M. Developing a neural prosthesis for hippocampus: proof-of-concept using the in vitro slice. [Internet] [Doctoral dissertation]. University of Southern California; 2009. [cited 2018 Apr 20]. Available from: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll127/id/236331/rec/1895.

Council of Science Editors:

Hsiao M. Developing a neural prosthesis for hippocampus: proof-of-concept using the in vitro slice. [Doctoral Dissertation]. University of Southern California; 2009. Available from: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll127/id/236331/rec/1895

Ruhr Universität Bochum

29. Hagena, Hardy. Examination of the role of long-term synaptic plasticity at hippocampal CA3 synapses in spatial memory.

Degree: 2009, Ruhr Universität Bochum

URL: http://nbn-resolving.de/urn/resolver.pl?urn=urn:nbn:de:hbz:294-26858

► Wir haben untersucht, ob die Frequenz Faszilitierung, eine charakteristische Eigenschaft der Moosfaser-CA3 Synapse, nachhaltige funktionelle Konsequenzen für die Verarbeitung von Informationen hat. Ein Teil dieser… (more)

Subjects/Keywords: Hippocampus; Plastizität; Lernen; Adenosin; Proteinsynthese

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Hagena, H. (2009). Examination of the role of long-term synaptic plasticity at hippocampal CA3 synapses in spatial memory. (Thesis). Ruhr Universität Bochum. Retrieved from http://nbn-resolving.de/urn/resolver.pl?urn=urn:nbn:de:hbz:294-26858

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Hagena, Hardy. “Examination of the role of long-term synaptic plasticity at hippocampal CA3 synapses in spatial memory.” 2009. Thesis, Ruhr Universität Bochum. Accessed April 20, 2018. http://nbn-resolving.de/urn/resolver.pl?urn=urn:nbn:de:hbz:294-26858.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Hagena, Hardy. “Examination of the role of long-term synaptic plasticity at hippocampal CA3 synapses in spatial memory.” 2009. Web. 20 Apr 2018.

Vancouver:

Hagena H. Examination of the role of long-term synaptic plasticity at hippocampal CA3 synapses in spatial memory. [Internet] [Thesis]. Ruhr Universität Bochum; 2009. [cited 2018 Apr 20]. Available from: http://nbn-resolving.de/urn/resolver.pl?urn=urn:nbn:de:hbz:294-26858.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Hagena H. Examination of the role of long-term synaptic plasticity at hippocampal CA3 synapses in spatial memory. [Thesis]. Ruhr Universität Bochum; 2009. Available from: http://nbn-resolving.de/urn/resolver.pl?urn=urn:nbn:de:hbz:294-26858

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Ruhr Universität Bochum

30. Brühl, Hannah. From insulin resistance to type 2 diabetes mellitus : the relationship of metabolic dysregulation, HPA axis, and retinal vessels to cognition and the brain.

Degree: 2009, Ruhr Universität Bochum

URL: http://nbn-resolving.de/urn/resolver.pl?urn=urn:nbn:de:hbz:294-27533

► In dieser Dissertationsschrift sollten die Auswirkungen von Typ 2 Diabetes Mellitus (T2DM) und zugrundeliegender Insulinresistenz (IR) auf Kognition und Gehirnstruktur ermittelt werden. Dabei wurden Faktoren… (more)

Subjects/Keywords: Altersdiabetes; Fettsucht; Stress; Hippocampus; Gedächtnis

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Brühl, H. (2009). From insulin resistance to type 2 diabetes mellitus : the relationship of metabolic dysregulation, HPA axis, and retinal vessels to cognition and the brain. (Thesis). Ruhr Universität Bochum. Retrieved from http://nbn-resolving.de/urn/resolver.pl?urn=urn:nbn:de:hbz:294-27533

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Brühl, Hannah. “From insulin resistance to type 2 diabetes mellitus : the relationship of metabolic dysregulation, HPA axis, and retinal vessels to cognition and the brain.” 2009. Thesis, Ruhr Universität Bochum. Accessed April 20, 2018. http://nbn-resolving.de/urn/resolver.pl?urn=urn:nbn:de:hbz:294-27533.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Brühl, Hannah. “From insulin resistance to type 2 diabetes mellitus : the relationship of metabolic dysregulation, HPA axis, and retinal vessels to cognition and the brain.” 2009. Web. 20 Apr 2018.

Vancouver:

Brühl H. From insulin resistance to type 2 diabetes mellitus : the relationship of metabolic dysregulation, HPA axis, and retinal vessels to cognition and the brain. [Internet] [Thesis]. Ruhr Universität Bochum; 2009. [cited 2018 Apr 20]. Available from: http://nbn-resolving.de/urn/resolver.pl?urn=urn:nbn:de:hbz:294-27533.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Brühl H. From insulin resistance to type 2 diabetes mellitus : the relationship of metabolic dysregulation, HPA axis, and retinal vessels to cognition and the brain. [Thesis]. Ruhr Universität Bochum; 2009. Available from: http://nbn-resolving.de/urn/resolver.pl?urn=urn:nbn:de:hbz:294-27533

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

		in
And / Or
		in
And / Or
		in
And / Or
		in

Open Access Theses and Dissertations