subject:(Hippocampus)

University of Georgia

1. Mathilakath Keralapurath, Madhusudhanan. Factors affecting the synaptic plasticity of hippocampus: focus on stress and addiction.

Degree: PhD, Toxicology, 2014, University of Georgia

URL: http://purl.galileo.usg.edu/uga_etd/mathilakath-keralapurath_madhusudhanan_201405_phd

► Involvement of the hippocampus in learning and memory is well known. Despite maintaining a uniform intrinsic circuitry throughout the structure, there are evidences for significant… (more)

▼ Involvement of the hippocampus in learning and memory is well known. Despite maintaining a uniform intrinsic circuitry throughout the structure, there are evidences for significant functional differences between the septal (dorsal) and temporal (ventral) sectors of hippocampus. Appreciation for the role of ventral hippocampus in the emotive and reward associated behaviors is on the rise. Behavioral and lesion studies in rodents have suggested that hippocampus plays an important role in drug reinstatement behaviors, although confirmatory molecular and electrophysiological evidences are lacking in this aspect. To study the effects of cocaine, we employed either the locomotor sensitization protocol where the drug was non-contingently administered by the experimenter, or we utilized the self-administration protocol where the rats were allowed to voluntarily administer drugs. Additionally, hippocampal feedback regulation of the hypothalamus-pituitary-adrenal axis is critical in the body’s response to stress. We investigated the effects of minor stressors such as novelty, handling and i.p. injections associated with a locomotor sensitization protocol on the hippocampal synaptic plasticity. We found that the minor, intermittent stressors associated with commonly employed behavioral protocols were sufficient to induce persistent stress-like effects. Cocaine, either experimenter administered or self-administered by the rats, specifically altered synaptic properties in the ventral hippocampus, albeit in different ways. Non-contingent cocaine exposures acted as metaplastic triggers and persistently enhanced the artificially induced LTP in the ventral hippocampus for at least 2 weeks after the last injection. In contrast, cocaine self-administration resulted in persistent enhancement of basal synaptic transmission in the ventral hippocampus, with both increases in excitatory glutamatergic activity and suppression of GABAergic inhibition being observed. Unlike in the non-contingently exposed groups, cocaine self-administration resulted in the suppression of LTP in the ventral hippocampus, suggesting a causal link between impaired learning and addicted states observed in the human subjects. Increased sensitivity of the ventral sector of the hippocampus to stress and drugs of abuse indicate its importance in the neuronal circuitry as a key intersection point where these co-morbidities of stress and drugs of abuse overlap. Advisors/Committee Members: John Wagner.

Subjects/Keywords: hippocampus

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APA (6^th Edition):

Mathilakath Keralapurath, M. (2014). Factors affecting the synaptic plasticity of hippocampus: focus on stress and addiction. (Doctoral Dissertation). University of Georgia. Retrieved from http://purl.galileo.usg.edu/uga_etd/mathilakath-keralapurath_madhusudhanan_201405_phd

Chicago Manual of Style (16^th Edition):

Mathilakath Keralapurath, Madhusudhanan. “Factors affecting the synaptic plasticity of hippocampus: focus on stress and addiction.” 2014. Doctoral Dissertation, University of Georgia. Accessed February 22, 2020. http://purl.galileo.usg.edu/uga_etd/mathilakath-keralapurath_madhusudhanan_201405_phd.

MLA Handbook (7^th Edition):

Mathilakath Keralapurath, Madhusudhanan. “Factors affecting the synaptic plasticity of hippocampus: focus on stress and addiction.” 2014. Web. 22 Feb 2020.

Vancouver:

Mathilakath Keralapurath M. Factors affecting the synaptic plasticity of hippocampus: focus on stress and addiction. [Internet] [Doctoral dissertation]. University of Georgia; 2014. [cited 2020 Feb 22]. Available from: http://purl.galileo.usg.edu/uga_etd/mathilakath-keralapurath_madhusudhanan_201405_phd.

Council of Science Editors:

Mathilakath Keralapurath M. Factors affecting the synaptic plasticity of hippocampus: focus on stress and addiction. [Doctoral Dissertation]. University of Georgia; 2014. Available from: http://purl.galileo.usg.edu/uga_etd/mathilakath-keralapurath_madhusudhanan_201405_phd

Wake Forest University

2. Haynes, Kathryn Alice. The Role of Ubiquitin-Proteasome-Mediated Proteolysis in Long-term Synaptic Plasticity.

Degree: 2015, Wake Forest University

URL: http://hdl.handle.net/10339/57156

► Elucidating mechanisms by which synapses are modified for long-term memory storage is crucial for explaining normal brain function as well as diseases and disorders of… (more)

▼ Elucidating mechanisms by which synapses are modified for long-term memory storage is crucial for explaining normal brain function as well as diseases and disorders of the brain. Numerous studies have shown that new gene expression and new protein synthesis are essential for the synaptic changes that give rise to long-term memory. More recent studies indicate that proteolysis by the ubiquitin-proteasome pathway (UPP) plays a critical role in long-term synaptic plasticity, and dysregulation of this pathway is associated with cognitive impairments in neurodegenerative diseases such as Alzheimer’s, Parkinson’s, and Huntington’s disease. Using the cellular model for long-term synaptic plasticity, late-phase long-term potentiation (L-LTP), our work reveals intricate interactions between proteolysis, protein synthesis in the dendrites and gene transcription in the nucleus. Previously, we showed that the early induction phase of L-LTP, which depends on local protein synthesis within dendrites, is enhanced by proteasome inhibition. We also observed that the later maintenance phase of L-LTP, which relies on translation of newly transcribed mRNAs, is blocked when the proteasome is inhibited. We hypothesized that the proteasome must be regulating both phases of L-LTP by controlling translation within dendrites and transcription within the nucleus. Supporting this hypothesis, we found two translational activators that increase early in L-LTP and two translational repressors that buildup later in L-LTP. Inhibition of the proteasome prior to L-LTP resulted in significant increases in expression of both translation activators and repressors, suggesting that this temporal regulation of translation might contribute to the proteasome’s role in the regulation of L-LTP induction and maintenance. In addition, proteasome inhibition prior to LTP induction significantly increases overall protein synthesis and initially slows protein degradation. Interestingly, we also found that amyloid –β (Aβ) drastically decreases basal and activity-dependent protein synthesis, while proteasome inhibition prior to Aβ treatment rescues this decrease back to control and LTP levels, respectively. Finally, taking a step away from translation and investigating the role of the proteasome in transcriptional regulation, we found that a transcriptional repressor, ATF4, is phosphorylated and degraded early in LTP, indicating a potential critical role for the proteasome in relieving repression of transcription during memory consolidation. These findings shed light on the proteasome-dependent mechanisms behind gene and protein expression in synaptic plasticity and could aide in finding novel therapeutic targets and biomarkers for ameliorating memory impairments in neurodegenerative diseases.

Subjects/Keywords: Hippocampus

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APA (6^th Edition):

Haynes, K. A. (2015). The Role of Ubiquitin-Proteasome-Mediated Proteolysis in Long-term Synaptic Plasticity. (Thesis). Wake Forest University. Retrieved from http://hdl.handle.net/10339/57156

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Haynes, Kathryn Alice. “The Role of Ubiquitin-Proteasome-Mediated Proteolysis in Long-term Synaptic Plasticity.” 2015. Thesis, Wake Forest University. Accessed February 22, 2020. http://hdl.handle.net/10339/57156.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Haynes, Kathryn Alice. “The Role of Ubiquitin-Proteasome-Mediated Proteolysis in Long-term Synaptic Plasticity.” 2015. Web. 22 Feb 2020.

Vancouver:

Haynes KA. The Role of Ubiquitin-Proteasome-Mediated Proteolysis in Long-term Synaptic Plasticity. [Internet] [Thesis]. Wake Forest University; 2015. [cited 2020 Feb 22]. Available from: http://hdl.handle.net/10339/57156.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Haynes KA. The Role of Ubiquitin-Proteasome-Mediated Proteolysis in Long-term Synaptic Plasticity. [Thesis]. Wake Forest University; 2015. Available from: http://hdl.handle.net/10339/57156

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Texas – Austin

3. Clemens, Ann M. Adaptive responses to cellular stress in neurons of the hippocampus.

Degree: PhD, Neuroscience, 2013, University of Texas – Austin

URL: http://hdl.handle.net/2152/26613

► Disruptions of endoplasmic reticulum (ER) Ca²⁺ homeostasis are heavily linked to neuronal pathology. Depletion of ER Ca²⁺ stores can result in cellular dysfunction and potentially… (more)

Subjects/Keywords: Hippocampus

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Clemens, A. M. (2013). Adaptive responses to cellular stress in neurons of the hippocampus. (Doctoral Dissertation). University of Texas – Austin. Retrieved from http://hdl.handle.net/2152/26613

Chicago Manual of Style (16^th Edition):

Clemens, Ann M. “Adaptive responses to cellular stress in neurons of the hippocampus.” 2013. Doctoral Dissertation, University of Texas – Austin. Accessed February 22, 2020. http://hdl.handle.net/2152/26613.

MLA Handbook (7^th Edition):

Clemens, Ann M. “Adaptive responses to cellular stress in neurons of the hippocampus.” 2013. Web. 22 Feb 2020.

Vancouver:

Clemens AM. Adaptive responses to cellular stress in neurons of the hippocampus. [Internet] [Doctoral dissertation]. University of Texas – Austin; 2013. [cited 2020 Feb 22]. Available from: http://hdl.handle.net/2152/26613.

Council of Science Editors:

Clemens AM. Adaptive responses to cellular stress in neurons of the hippocampus. [Doctoral Dissertation]. University of Texas – Austin; 2013. Available from: http://hdl.handle.net/2152/26613

University of New Mexico

4. Scullin, Chessa. Development of presynaptic calcium dynamics and short-term plasticity in the SC-Ca1 synapse.

Degree: Biomedical Sciences Graduate Program, 2010, University of New Mexico

URL: https://digitalrepository.unm.edu/biom_etds/18

► Following a presynaptic action potential, there is a rapid rise of [Ca2+]i in the immediate vicinity of Ca2+ channels that triggers membrane fusion and release… (more)

▼ Following a presynaptic action potential, there is a rapid rise of [Ca2+]i in the immediate vicinity of Ca2+ channels that triggers membrane fusion and release of transmitter from vesicles within this microdomain. This presynaptic Ca2+ signal ([Ca2+]pre) then disperses to produce a residual Ca2+ ([Ca2+]res) that decays over the course of tens to hundreds of milliseconds. The [Ca2+]res has important implications in synaptic plasticity and is the basis for working memory storage. Ultimately [Ca2+]res is removed from the cytoplasm either into intracellular organelles or across the plasma membrane into the extracellular environment. Calcium influx pathways, cytoplasmic Ca2+ buffering proteins, and Ca2+ extrusion processes in rodent neurons undergo considerable change during the first postnatal month. These changes have important functional significance in short-term plasticity — in particular paired-pulse facilitation (PPF) — at presynaptic terminals where neurotransmitter release is directly dependent on the dynamics of free cytoplasmic Ca2+. To examine developmental changes in [Ca2+]res dynamics in the Schaffer collateral synapses onto CA1 pyramidal neurons in in vitro hippocampal slices, we measured the timecourse of decay of [Ca2+]res in presynaptic terminals following single and paired orthodromic stimuli in the stratum radiatum. The contribution of the slow component compared to the total decay of [Ca2+]res was reduced from >80% in newborn mice to ~50% in the more mature animals (>P24) and [Ca2+]res had a distinct slow rising component in newborn mice (<P4), which was not apparent in older mice. This transition from a slow decay in early neonatal periods to the rapid decay in adults occurred gradually over the first 4 weeks of postnatal life, and appeared to be coincident with the major period of maturation of these synapses. The first goal of this study was to investigate the role of internal stores in regulating presynaptic [Ca2+] and in synaptic plasticity during this important period of synaptic development. During this same developmental period, SNAP-25, a presynaptic vesicular release protein, undergoes changes in isoform expression. Alterations in SNAP-25 isoform expression have been linked to diseases with developmental onset such as schizophrenia, attention deficit hyperactivity disorder, and epilepsy (Corradini et al., 2009). Snap25tm2Mcw mice (Tkneo), in which this developmental change of isoform expression is modified (Bark et al., 2004), appear to retain an immature state of paired-pulse facilitation. The second goal of this study was to use these Tkneo mice as a tool to better understand the mechanisms of synaptic plasticity and to better understand how SNAP-25 regulation could underlie neurological disorders. We applied a model for paired-pulse facilitation (Schiess et al., 2006), which describes facilitation as a function of two [Ca2+]res-dependent pools of vesicles with different release probabilities. This model predicted the observed external [Ca2+]-dependent changes in… Advisors/Committee Members: Partridge, L. Donald, Wilson, Michael, Thomas, James, Hartley, Rebecca, Shuttleworth, C. William.

Subjects/Keywords: calcium; hippocampus

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Scullin, C. (2010). Development of presynaptic calcium dynamics and short-term plasticity in the SC-Ca1 synapse. (Doctoral Dissertation). University of New Mexico. Retrieved from https://digitalrepository.unm.edu/biom_etds/18

Chicago Manual of Style (16^th Edition):

Scullin, Chessa. “Development of presynaptic calcium dynamics and short-term plasticity in the SC-Ca1 synapse.” 2010. Doctoral Dissertation, University of New Mexico. Accessed February 22, 2020. https://digitalrepository.unm.edu/biom_etds/18.

MLA Handbook (7^th Edition):

Scullin, Chessa. “Development of presynaptic calcium dynamics and short-term plasticity in the SC-Ca1 synapse.” 2010. Web. 22 Feb 2020.

Vancouver:

Scullin C. Development of presynaptic calcium dynamics and short-term plasticity in the SC-Ca1 synapse. [Internet] [Doctoral dissertation]. University of New Mexico; 2010. [cited 2020 Feb 22]. Available from: https://digitalrepository.unm.edu/biom_etds/18.

Council of Science Editors:

Scullin C. Development of presynaptic calcium dynamics and short-term plasticity in the SC-Ca1 synapse. [Doctoral Dissertation]. University of New Mexico; 2010. Available from: https://digitalrepository.unm.edu/biom_etds/18

Brandeis University

5. Sanders, Honi. Perspectives on Computation in Oscillatory Networks in the Brain.

Degree: 2016, Brandeis University

URL: http://hdl.handle.net/10192/32067

► This thesis explores possible roles of oscillations in the brain. Computer simulations demonstrate the robustness of dendritic voltage bistability, a mechanism for working mem- ory,… (more)

Subjects/Keywords: Neuroscience; Hippocampus

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APA (6^th Edition):

Sanders, H. (2016). Perspectives on Computation in Oscillatory Networks in the Brain. (Thesis). Brandeis University. Retrieved from http://hdl.handle.net/10192/32067

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Sanders, Honi. “Perspectives on Computation in Oscillatory Networks in the Brain.” 2016. Thesis, Brandeis University. Accessed February 22, 2020. http://hdl.handle.net/10192/32067.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Sanders, Honi. “Perspectives on Computation in Oscillatory Networks in the Brain.” 2016. Web. 22 Feb 2020.

Vancouver:

Sanders H. Perspectives on Computation in Oscillatory Networks in the Brain. [Internet] [Thesis]. Brandeis University; 2016. [cited 2020 Feb 22]. Available from: http://hdl.handle.net/10192/32067.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Sanders H. Perspectives on Computation in Oscillatory Networks in the Brain. [Thesis]. Brandeis University; 2016. Available from: http://hdl.handle.net/10192/32067

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Alberta

6. McEown, Kristopher. The roles of the dorsal and ventral hippocampus in fear and memory of a shock probe experience.

Degree: MS, Department of Psychology, 2009, University of Alberta

URL: https://era.library.ualberta.ca/files/2f75r905d

► This thesis examined the effects of temporary inactivation of the dorsal or ventral hippocampus on unconditioned and conditioned fear, using the shock-probe test. Rats received… (more)

Subjects/Keywords: fear; hippocampus; memory

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APA (6^th Edition):

McEown, K. (2009). The roles of the dorsal and ventral hippocampus in fear and memory of a shock probe experience. (Masters Thesis). University of Alberta. Retrieved from https://era.library.ualberta.ca/files/2f75r905d

Chicago Manual of Style (16^th Edition):

McEown, Kristopher. “The roles of the dorsal and ventral hippocampus in fear and memory of a shock probe experience.” 2009. Masters Thesis, University of Alberta. Accessed February 22, 2020. https://era.library.ualberta.ca/files/2f75r905d.

MLA Handbook (7^th Edition):

McEown, Kristopher. “The roles of the dorsal and ventral hippocampus in fear and memory of a shock probe experience.” 2009. Web. 22 Feb 2020.

Vancouver:

McEown K. The roles of the dorsal and ventral hippocampus in fear and memory of a shock probe experience. [Internet] [Masters thesis]. University of Alberta; 2009. [cited 2020 Feb 22]. Available from: https://era.library.ualberta.ca/files/2f75r905d.

Council of Science Editors:

McEown K. The roles of the dorsal and ventral hippocampus in fear and memory of a shock probe experience. [Masters Thesis]. University of Alberta; 2009. Available from: https://era.library.ualberta.ca/files/2f75r905d

7. Toritsuka, Michihiro; Kimoto, Sohei; Muraki, Kazue; Landek-Salgado, Melissa A; Yoshida, Atsuhiro; Yamamoto, Norio; Horiuchi, Yasue; Hiyama, Hideki; Tajinda, Katsunori; Keni, Ni; Illingworth, Elizabeth; Iwamoto, Takashi; Kishimoto, Toshifumi; Sawa, Akira. Deficits in microRNA-mediated Cxcr4/Cxcl12 signaling in neurodevelopmental deficits in a 22q11 deletion syndrome mouse model. : 22q11欠失症候群モデルマウスの神経発達障害には、マイクロRNAが介在するCxcr4/Cxcl12シグナリングの欠損が寄与する.

Degree: 博士（医学）, 2014, Nara Medical University / 奈良県立医科大学

URL: http://hdl.handle.net/10564/2716

►

22q11 deletion syndrome (22q11DS) frequently accompanies psychiatric conditions, some of which are classified as schizophrenia and bipolar disorder in the current diagnostic categorization. However, it… (more)

Subjects/Keywords: hippocampus; dentate gyrus

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APA (6^th Edition):

Toritsuka, Michihiro; Kimoto, Sohei; Muraki, Kazue; Landek-Salgado, Melissa A; Yoshida, Atsuhiro; Yamamoto, Norio; Horiuchi, Yasue; Hiyama, Hideki; Tajinda, Katsunori; Keni, Ni; Illingworth, Elizabeth; Iwamoto, Takashi; Kishimoto, Toshifumi; Sawa, A. (2014). Deficits in microRNA-mediated Cxcr4/Cxcl12 signaling in neurodevelopmental deficits in a 22q11 deletion syndrome mouse model. : 22q11欠失症候群モデルマウスの神経発達障害には、マイクロRNAが介在するCxcr4/Cxcl12シグナリングの欠損が寄与する. (Thesis). Nara Medical University / 奈良県立医科大学. Retrieved from http://hdl.handle.net/10564/2716

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Toritsuka, Michihiro; Kimoto, Sohei; Muraki, Kazue; Landek-Salgado, Melissa A; Yoshida, Atsuhiro; Yamamoto, Norio; Horiuchi, Yasue; Hiyama, Hideki; Tajinda, Katsunori; Keni, Ni; Illingworth, Elizabeth; Iwamoto, Takashi; Kishimoto, Toshifumi; Sawa, Akira. “Deficits in microRNA-mediated Cxcr4/Cxcl12 signaling in neurodevelopmental deficits in a 22q11 deletion syndrome mouse model. : 22q11欠失症候群モデルマウスの神経発達障害には、マイクロRNAが介在するCxcr4/Cxcl12シグナリングの欠損が寄与する.” 2014. Thesis, Nara Medical University / 奈良県立医科大学. Accessed February 22, 2020. http://hdl.handle.net/10564/2716.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Toritsuka, Michihiro; Kimoto, Sohei; Muraki, Kazue; Landek-Salgado, Melissa A; Yoshida, Atsuhiro; Yamamoto, Norio; Horiuchi, Yasue; Hiyama, Hideki; Tajinda, Katsunori; Keni, Ni; Illingworth, Elizabeth; Iwamoto, Takashi; Kishimoto, Toshifumi; Sawa, Akira. “Deficits in microRNA-mediated Cxcr4/Cxcl12 signaling in neurodevelopmental deficits in a 22q11 deletion syndrome mouse model. : 22q11欠失症候群モデルマウスの神経発達障害には、マイクロRNAが介在するCxcr4/Cxcl12シグナリングの欠損が寄与する.” 2014. Web. 22 Feb 2020.

Vancouver:

Toritsuka, Michihiro; Kimoto, Sohei; Muraki, Kazue; Landek-Salgado, Melissa A; Yoshida, Atsuhiro; Yamamoto, Norio; Horiuchi, Yasue; Hiyama, Hideki; Tajinda, Katsunori; Keni, Ni; Illingworth, Elizabeth; Iwamoto, Takashi; Kishimoto, Toshifumi; Sawa A. Deficits in microRNA-mediated Cxcr4/Cxcl12 signaling in neurodevelopmental deficits in a 22q11 deletion syndrome mouse model. : 22q11欠失症候群モデルマウスの神経発達障害には、マイクロRNAが介在するCxcr4/Cxcl12シグナリングの欠損が寄与する. [Internet] [Thesis]. Nara Medical University / 奈良県立医科大学; 2014. [cited 2020 Feb 22]. Available from: http://hdl.handle.net/10564/2716.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Toritsuka, Michihiro; Kimoto, Sohei; Muraki, Kazue; Landek-Salgado, Melissa A; Yoshida, Atsuhiro; Yamamoto, Norio; Horiuchi, Yasue; Hiyama, Hideki; Tajinda, Katsunori; Keni, Ni; Illingworth, Elizabeth; Iwamoto, Takashi; Kishimoto, Toshifumi; Sawa A. Deficits in microRNA-mediated Cxcr4/Cxcl12 signaling in neurodevelopmental deficits in a 22q11 deletion syndrome mouse model. : 22q11欠失症候群モデルマウスの神経発達障害には、マイクロRNAが介在するCxcr4/Cxcl12シグナリングの欠損が寄与する. [Thesis]. Nara Medical University / 奈良県立医科大学; 2014. Available from: http://hdl.handle.net/10564/2716

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Victoria

8. Simpson, Jessica M. Altered Adult Hippocampal Structural and Functional Plasticity in the YAC128 Transgenic Mouse Model of Huntington Disease.

Degree: Dept. of Biology, 2013, University of Victoria

URL: http://hdl.handle.net/1828/4978

► Alterations in both structural and synaptic plasticity in the adult brain have been implicated in impaired learning and memory. In the present study, we investigated… (more)

Subjects/Keywords: Huntington's chorea; Hippocampus

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APA (6^th Edition):

Simpson, J. M. (2013). Altered Adult Hippocampal Structural and Functional Plasticity in the YAC128 Transgenic Mouse Model of Huntington Disease. (Masters Thesis). University of Victoria. Retrieved from http://hdl.handle.net/1828/4978

Chicago Manual of Style (16^th Edition):

Simpson, Jessica M. “Altered Adult Hippocampal Structural and Functional Plasticity in the YAC128 Transgenic Mouse Model of Huntington Disease.” 2013. Masters Thesis, University of Victoria. Accessed February 22, 2020. http://hdl.handle.net/1828/4978.

MLA Handbook (7^th Edition):

Simpson, Jessica M. “Altered Adult Hippocampal Structural and Functional Plasticity in the YAC128 Transgenic Mouse Model of Huntington Disease.” 2013. Web. 22 Feb 2020.

Vancouver:

Simpson JM. Altered Adult Hippocampal Structural and Functional Plasticity in the YAC128 Transgenic Mouse Model of Huntington Disease. [Internet] [Masters thesis]. University of Victoria; 2013. [cited 2020 Feb 22]. Available from: http://hdl.handle.net/1828/4978.

Council of Science Editors:

Simpson JM. Altered Adult Hippocampal Structural and Functional Plasticity in the YAC128 Transgenic Mouse Model of Huntington Disease. [Masters Thesis]. University of Victoria; 2013. Available from: http://hdl.handle.net/1828/4978

University of Otago

9. Seo, Steve. Spatial Learning-Induced Changes at Agmatinergic and Glutamatergic Synapses in the Hippocampal CA1 Region .

Degree: 2011, University of Otago

URL: http://hdl.handle.net/10523/1824

► Agmatine, a metabolite of L-arginine, is considered to be a novel putative neurotransmitter and has been implicated in spatial learning and memory processes. Agmatine-immunoreactivity has… (more)

▼ Agmatine, a metabolite of L-arginine, is considered to be a novel putative neurotransmitter and has been implicated in spatial learning and memory processes. Agmatine-immunoreactivity has been found in synaptic terminals of asymmetric excitatory synapses in the hippocampal CA1 region, which suggests that agmatine may be co-localized with glutamate, the primary excitatory neurotransmitter of hippocampal pyramidal cells. The first aim of the current project was to investigate if agmatine is co-localized with glutamate in the hippocampal pyramidal cells and within synaptic terminals at CA1 synapses, using immunofluorescence confocal microscopy and post-embedding electron microscopy-immunogold cytochemistry, respectively. Double immunofluorescence labelling indicated that agmatine and glutamate are co-localized in the majority of CA1-CA3 pyramidal cell bodies. Immunogold double labelling demonstrated that agmatine is also co-localized with glutamate in synaptic terminals in the CA1 stratum radiatum (SR) region. In the CA1 region of young male Sprague-Dawley rats, 97% of all agmatinergic profiles contained glutamate, and 92% of all glutamatergic profiles also contained agmatine (n = 6; 300 terminals). Having established co-localization of agmatine with glutamate within CA1 SR terminals, the second aim of the project was to investigate changes in co-localized agmatine and glutamate levels following 4 days Morris water maze training. The water maze trained rats (n = 3) showed significant increases in both agmatine and glutamate levels in the CA1 SR terminals (150 terminals; 78% increase in agmatine, p<0.01; ~41% increase in glutamate, p<0.05), compared to swim only control rats (n = 3; 150 terminals). The finding that water maze training induced increases in both agmatine and glutamate levels in the CA1 terminals, suggests that agmatine may play a role with glutamate in learning and memory processes. The final aim of the study was to examine possible spatial learning-induced structural changes at the postsynaptic site. The average thickness of the postsynaptic density at CA1 SR synapses (n = 240) was analysed. The water maze trained rats exhibited a 30% increase in their average postsynaptic density thickness (p < 0.001) compared to control rats. This suggests that there are alterations in the molecular components in the postsynaptic density following water maze training, which could lead to functional modifications of the postsynaptic neuron. Further studies are required to elucidate the molecular mechanisms by which agmatine may influence learning and memory processes, and to explore the functional significance of spatial learning induced increases in agmatine and glutamate levels and PSD thickness at CA1 SR synapses. Advisors/Committee Members: Leitch, Beulah (advisor).

Subjects/Keywords: Agmatine; Learning; Hippocampus

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APA (6^th Edition):

Seo, S. (2011). Spatial Learning-Induced Changes at Agmatinergic and Glutamatergic Synapses in the Hippocampal CA1 Region . (Masters Thesis). University of Otago. Retrieved from http://hdl.handle.net/10523/1824

Chicago Manual of Style (16^th Edition):

Seo, Steve. “Spatial Learning-Induced Changes at Agmatinergic and Glutamatergic Synapses in the Hippocampal CA1 Region .” 2011. Masters Thesis, University of Otago. Accessed February 22, 2020. http://hdl.handle.net/10523/1824.

MLA Handbook (7^th Edition):

Seo, Steve. “Spatial Learning-Induced Changes at Agmatinergic and Glutamatergic Synapses in the Hippocampal CA1 Region .” 2011. Web. 22 Feb 2020.

Vancouver:

Seo S. Spatial Learning-Induced Changes at Agmatinergic and Glutamatergic Synapses in the Hippocampal CA1 Region . [Internet] [Masters thesis]. University of Otago; 2011. [cited 2020 Feb 22]. Available from: http://hdl.handle.net/10523/1824.

Council of Science Editors:

Seo S. Spatial Learning-Induced Changes at Agmatinergic and Glutamatergic Synapses in the Hippocampal CA1 Region . [Masters Thesis]. University of Otago; 2011. Available from: http://hdl.handle.net/10523/1824

Tulane University

10. Homiack, Damek. Mechanisms by which Acute or Chronic Stress Exposure Modulates CREB Phosphorylation in the Hippocampus in a Sex-Specific Manner.

Degree: 2017, Tulane University

URL: https://digitallibrary.tulane.edu/islandora/object/tulane:75315

►

Women are at greater risk to develop the incurable psychiatric diseases posttraumatic stress disorder (PTSD) and major depressive disorder (MDD). In spite of the elevated… (more)

▼

Women are at greater risk to develop the incurable psychiatric diseases posttraumatic stress disorder (PTSD) and major depressive disorder (MDD). In spite of the elevated risk associated with female biological sex, the vast majority of preclinical studies have exclusively used male rodents. Therefore, the neurobiology which underlies the increased susceptibility to stress-related mental illness associated with female sex is largely unknown. Currently, it is thought that regulation of the transcription factor cyclic-AMP response element binding protein (CREB) may act as a molecular locus capable of transducing aversive experiences into lasting changes in the structure and function of neurons in the hippocampus. However, the signal transduction cascades recruited by stress to modulate CREB activity are less well understood. Therefore, the goal of this thesis was to investigate stress-induced modulation of CREB phosphorylation and upstream signaling cascades in the hippocampus of male and female rodents exposed to severe stress. Exposure to either acute predator odor stress or chronic variable stress reduced phosphorylation of CREB in the male, but not the female hippocampus. Predator odor exposure rapidly reduced phosphorylation of extracellular signal-regulated kinase and increased nuclear expression of the synapto-nuclear messenger protein Jacob in the male hippocampus, consistent with the previously described CREB shut-off cascade. Chronic variable stress affected the activity of Sirtuin1, a metabolically-sensitive deacetylase known to interact with CREB, in the male, but not the female dentate gyrus sub-area of the hippocampus, possibly through recruitment of adenosine monophosphate activated protein kinase. Behaviorally, female rodents exposed to predator odor exhibited an impaired ability to discriminate between a context previously paired with the predator odor and a neutral context, possibly representing a fear over-generalizing phenotype. In contrast female rodents exposed to chronic variable stress did not exhibit the altered metabolic phenotypes observed in male rodents exposed to chronic variable stress, suggesting that females are more resilient to chronic stress. Collectively, these data suggest that the female hippocampus resists changes in CREB phosphorylation associated with severe stress which may contribute to sex differences observed in stress-related mental health disorders.

1

Damek Homiack

Advisors/Committee Members: (author), Schrader, Laura (Thesis advisor), (Thesis advisor), School of Science & Engineering Neuroscience (Degree granting institution), NULL (Degree granting institution).

Subjects/Keywords: Hippocampus; CREB; Stress

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Homiack, D. (2017). Mechanisms by which Acute or Chronic Stress Exposure Modulates CREB Phosphorylation in the Hippocampus in a Sex-Specific Manner. (Thesis). Tulane University. Retrieved from https://digitallibrary.tulane.edu/islandora/object/tulane:75315

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Homiack, Damek. “Mechanisms by which Acute or Chronic Stress Exposure Modulates CREB Phosphorylation in the Hippocampus in a Sex-Specific Manner.” 2017. Thesis, Tulane University. Accessed February 22, 2020. https://digitallibrary.tulane.edu/islandora/object/tulane:75315.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Homiack, Damek. “Mechanisms by which Acute or Chronic Stress Exposure Modulates CREB Phosphorylation in the Hippocampus in a Sex-Specific Manner.” 2017. Web. 22 Feb 2020.

Vancouver:

Homiack D. Mechanisms by which Acute or Chronic Stress Exposure Modulates CREB Phosphorylation in the Hippocampus in a Sex-Specific Manner. [Internet] [Thesis]. Tulane University; 2017. [cited 2020 Feb 22]. Available from: https://digitallibrary.tulane.edu/islandora/object/tulane:75315.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Homiack D. Mechanisms by which Acute or Chronic Stress Exposure Modulates CREB Phosphorylation in the Hippocampus in a Sex-Specific Manner. [Thesis]. Tulane University; 2017. Available from: https://digitallibrary.tulane.edu/islandora/object/tulane:75315

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Texas Southwestern Medical Center

11. Bulin, Sarah Elizabeth. The Role of Adult Hippocampal Neurogenesis in Morphine Addiction.

Degree: 2015, University of Texas Southwestern Medical Center

URL: http://hdl.handle.net/2152.5/4130

► The hippocampus plays a large role in modulating the reward pathway, being especially important in craving and context-dependent relapse. One form a neuroplasticity within the… (more)

▼ The hippocampus plays a large role in modulating the reward pathway, being especially important in craving and context-dependent relapse. One form a neuroplasticity within the hippocampus is adult neurogenesis, which occurs in the subgranular zone of the dentate gyrus. While a growing amount of literature has explored the effects of drugs of abuse on adult DG neurogenesis, the relationship between self-administered opiates and adult DG neurogenesis remains unexplored. This dissertation investigates both the role of adult DG neurogenesis in morphine-related behaviors and the effects of self-administered opiates (morphine and heroin) on adult DG neurogenesis. I first explore the background literature important in the work completed within this dissertation (Chapter 1). Next, using a self-administration paradigm, I proceed to show that ablation of adult neurogenesis via cranial irradiation results in increased in morphine intake, decreased extinction, and decreased cognitive flexibility. Additionally, rats lacking adult DG neurogenesis exhibited increased morphine locomotor sensitization with increased DG activation in the infrablade after a low dose morphine challenge (Chapter 2). I will then go on to investigate the consequences of long-term self-administered opiates (morphine and heroin) on the different stages of maturation of adult-generated neurons. I demonstrate that morphine self-administration has no effect on proliferation, survival, or maturation immediately after exposure or after 28 days of withdrawal (Chapter 3). Additionally, I demonstrate that heroin self-administration does not alter DCX+ cell density or granule cell layer volume (Chapter 4). Taken together, my data suggests the adult DG neurogenesis is robust and normally unaffected by self-administered opiates. However, preexisting deficits in DG neurogenesis may lead to an increased vulnerability to addiction-related behaviors. In the final chapter (Chapter 5), I discuss potential implications of this work and future directions in which it may be taken. Advisors/Committee Members: Hsieh, Jenny, Self, David W., Powell, Craig M., Eisch, Amelia J..

Subjects/Keywords: Hippocampus; Morphine; Neurogenesis

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Bulin, S. E. (2015). The Role of Adult Hippocampal Neurogenesis in Morphine Addiction. (Thesis). University of Texas Southwestern Medical Center. Retrieved from http://hdl.handle.net/2152.5/4130

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Bulin, Sarah Elizabeth. “The Role of Adult Hippocampal Neurogenesis in Morphine Addiction.” 2015. Thesis, University of Texas Southwestern Medical Center. Accessed February 22, 2020. http://hdl.handle.net/2152.5/4130.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Bulin, Sarah Elizabeth. “The Role of Adult Hippocampal Neurogenesis in Morphine Addiction.” 2015. Web. 22 Feb 2020.

Vancouver:

Bulin SE. The Role of Adult Hippocampal Neurogenesis in Morphine Addiction. [Internet] [Thesis]. University of Texas Southwestern Medical Center; 2015. [cited 2020 Feb 22]. Available from: http://hdl.handle.net/2152.5/4130.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Bulin SE. The Role of Adult Hippocampal Neurogenesis in Morphine Addiction. [Thesis]. University of Texas Southwestern Medical Center; 2015. Available from: http://hdl.handle.net/2152.5/4130

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Texas Southwestern Medical Center

12. Perez, Jessica Marie. Hippocampal Subfield Transcriptome Analysis in Schizophrenia Psychosis.

Degree: 2018, University of Texas Southwestern Medical Center

URL: http://hdl.handle.net/2152.5/6147

► Schizophrenia is one of the thirty most incapacitating conditions in the world and affects tens of millions of people worldwide. Devastatingly, suicide occurs in 10%… (more)

▼ Schizophrenia is one of the thirty most incapacitating conditions in the world and affects tens of millions of people worldwide. Devastatingly, suicide occurs in 10% of those diagnosed with schizophrenia. Symptoms are persistent and often severe and available treatments are not curative. In fact, 20-33% of people with schizophrenia are entirely resistant to treatment. The complex symptom manifestations of schizophrenia lack a molecular pathology. Consequently, advances in novel treatment directions are limited. Schizophrenia is recognized as a polygenic disorder influenced by environmental factors. This dissertation aims to examine this polygenic nature of this disorder. Genome wide association studies have identified hundreds of common genetic variants, which individually confer a small risk for schizophrenia. However, all identified genetic variants combined only account for a modest amount of the total heritability of schizophrenia. In this dissertation, I capitalize on the unique ability of next-generation sequencing to identify in a global and unbiased manner molecular changes, which have not been previously hypothesized, but may contribute to the origin of the missing heritability of schizophrenia and play a role in schizophrenia symptomatology. The Tamminga lab has particular interest in schizophrenia psychosis, conceptualizing it as a disorder of learning and memory, critically involving dentate gyrus (DG), CA3, and CA1 of the hippocampus. Therefore, this doctoral dissertation examines the transcriptome of all three subfields, DG, CA3, and CA1 in human postmortem tissue of controls and individuals diagnosed with schizophrenia, using RNA-seq to identify additional psychosis-mediating molecular candidates and produce plausible targets for therapeutic treatment. After Chapters 1, 2, and 3 introduce the significance and contribution of this dissertation to the field of neuroscience in psychiatry, I show (Chapter 4) that each hippocampal subfield in schizophrenia has a unique molecular identity based on its transcriptome profile. As well, I show only slight effects of antipsychotic medication on schizophrenia-dependent gene changes in DG, CA3, and CA1. Taken together, my data identify molecular candidates and specific cell populations that we previously did not hypothesize as potential contributors to schizophrenia pathology. Finally, in Chapter 5, I outline future directions based on the contributions of my doctoral dissertation to the field. Advisors/Committee Members: Eisch, Amelia J., Tamminga, Carol, Kim, Tae-Kyung, Zinn, Andrew R..

Subjects/Keywords: Hippocampus; Schizophrenia; Transcriptome

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Perez, J. M. (2018). Hippocampal Subfield Transcriptome Analysis in Schizophrenia Psychosis. (Thesis). University of Texas Southwestern Medical Center. Retrieved from http://hdl.handle.net/2152.5/6147

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Perez, Jessica Marie. “Hippocampal Subfield Transcriptome Analysis in Schizophrenia Psychosis.” 2018. Thesis, University of Texas Southwestern Medical Center. Accessed February 22, 2020. http://hdl.handle.net/2152.5/6147.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Perez, Jessica Marie. “Hippocampal Subfield Transcriptome Analysis in Schizophrenia Psychosis.” 2018. Web. 22 Feb 2020.

Vancouver:

Perez JM. Hippocampal Subfield Transcriptome Analysis in Schizophrenia Psychosis. [Internet] [Thesis]. University of Texas Southwestern Medical Center; 2018. [cited 2020 Feb 22]. Available from: http://hdl.handle.net/2152.5/6147.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Perez JM. Hippocampal Subfield Transcriptome Analysis in Schizophrenia Psychosis. [Thesis]. University of Texas Southwestern Medical Center; 2018. Available from: http://hdl.handle.net/2152.5/6147

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Rutgers University

13. Yarotsky, John J. The association of p75NTR and co-receptors in hippocampal neurons and astrocytes.

Degree: PhD, Biology, 2015, Rutgers University

URL: https://rucore.libraries.rutgers.edu/rutgers-lib/47720/

►

Neurons in the hippocampus are dependent on neurotrophins for survival. Upon injury, proneurotrophins cause hippocampal neurons to undergo apoptosis. These two distinct effects can be… (more)

Subjects/Keywords: Hippocampus (Brain); Astrocytes

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APA (6^th Edition):

Yarotsky, J. J. (2015). The association of p75NTR and co-receptors in hippocampal neurons and astrocytes. (Doctoral Dissertation). Rutgers University. Retrieved from https://rucore.libraries.rutgers.edu/rutgers-lib/47720/

Chicago Manual of Style (16^th Edition):

Yarotsky, John J. “The association of p75NTR and co-receptors in hippocampal neurons and astrocytes.” 2015. Doctoral Dissertation, Rutgers University. Accessed February 22, 2020. https://rucore.libraries.rutgers.edu/rutgers-lib/47720/.

MLA Handbook (7^th Edition):

Yarotsky, John J. “The association of p75NTR and co-receptors in hippocampal neurons and astrocytes.” 2015. Web. 22 Feb 2020.

Vancouver:

Yarotsky JJ. The association of p75NTR and co-receptors in hippocampal neurons and astrocytes. [Internet] [Doctoral dissertation]. Rutgers University; 2015. [cited 2020 Feb 22]. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/47720/.

Council of Science Editors:

Yarotsky JJ. The association of p75NTR and co-receptors in hippocampal neurons and astrocytes. [Doctoral Dissertation]. Rutgers University; 2015. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/47720/

Rutgers University

14. Czerniawski, Jennifer, 1982-. NMDA receptor mediated expression of Arc in dorsal and ventral hippocampus contributes to the acquisition of contextual and trace fear conditioning.

Degree: PhD, Psychology, 2011, Rutgers University

URL: http://hdl.rutgers.edu/1782.1/rucore10001600001.ETD.000061173

►

The dorsal and ventral subregions of the hippocampus are differentially involved in several of types of learning, including fear conditioning. For example, we have previously… (more)

▼

The dorsal and ventral subregions of the hippocampus are differentially involved in several of types of learning, including fear conditioning. For example, we have previously demonstrated that the integrity of ventral, but not dorsal, hippocampus is necessary for the acquisition and expression of trace fear conditioning while dorsal, but not ventral, hippocampus is critically involved in spatially-guided reinforced alternation (Czerniawski, Yoon & Otto, 2009). In contrast to the partially dissociable effects of either lesions or inactivation, however, several lines of research suggest that, in intact subjects, both subregions are normally involved in the acquisition of many hippocampal-dependent tasks. The present studies investigated the molecular basis of these forms of learning by determining whether NMDA receptor-mediated immediate early gene expression in dorsal vs. ventral hippocampus contributes to the acquisition and/or retention of trace and contextual fear conditioning. In the first set of experiments we examined the effect of NMDA receptor antagonism in dorsal or ventral hippocampus on the acquisition or expression of trace and contextual fear conditioning. Next we assessed if trace fear conditioning alters the transcription and/or translation of Arc, an immediate early gene thought to be critically involved in some forms of plasticity and learning. In addition we examined the effect of blocking Arc translation with antisense oligodeoxynucleotides on the acquisition of CS-US associations in this paradigm. Lastly, in the final experiment we determined if the learning induced increase in Arc translation is NMDA receptor-dependent. The results of these studies suggest that both NMDA-receptor antagonism and the infusion of antisense oligodeoxynucleotides for the immediate early gene Arc (activity-regulated cytoskeletal protein) into dorsal or ventral hippocampus impair the acquisition of contextual and trace fear conditioning. In addition, trace fear conditioning enhances both Arc transcription and translation. Finally, pre-training infusions of either Arc antisense oligodeoxynucleotides or the NMDA receptor antagonist APV block the learning-induced enhancement of Arc. Together these studies support the notion that NMDA-receptor mediated expression of the immediate early gene Arc in both dorsal and ventral hippocampus may underlie the acquisition of a variety of forms of hippocampal dependent learning.

Advisors/Committee Members: Czerniawski, Jennifer, 1982- (author), Otto, Tim (chair), Shors, Tracey (internal member), McGann, John (internal member), Firestein, Bonnie (outside member).

Subjects/Keywords: Hippocampus (Brain); Fear

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Czerniawski, Jennifer, 1. (2011). NMDA receptor mediated expression of Arc in dorsal and ventral hippocampus contributes to the acquisition of contextual and trace fear conditioning. (Doctoral Dissertation). Rutgers University. Retrieved from http://hdl.rutgers.edu/1782.1/rucore10001600001.ETD.000061173

Chicago Manual of Style (16^th Edition):

Czerniawski, Jennifer, 1982-. “NMDA receptor mediated expression of Arc in dorsal and ventral hippocampus contributes to the acquisition of contextual and trace fear conditioning.” 2011. Doctoral Dissertation, Rutgers University. Accessed February 22, 2020. http://hdl.rutgers.edu/1782.1/rucore10001600001.ETD.000061173.

MLA Handbook (7^th Edition):

Czerniawski, Jennifer, 1982-. “NMDA receptor mediated expression of Arc in dorsal and ventral hippocampus contributes to the acquisition of contextual and trace fear conditioning.” 2011. Web. 22 Feb 2020.

Vancouver:

Czerniawski, Jennifer 1. NMDA receptor mediated expression of Arc in dorsal and ventral hippocampus contributes to the acquisition of contextual and trace fear conditioning. [Internet] [Doctoral dissertation]. Rutgers University; 2011. [cited 2020 Feb 22]. Available from: http://hdl.rutgers.edu/1782.1/rucore10001600001.ETD.000061173.

Council of Science Editors:

Czerniawski, Jennifer 1. NMDA receptor mediated expression of Arc in dorsal and ventral hippocampus contributes to the acquisition of contextual and trace fear conditioning. [Doctoral Dissertation]. Rutgers University; 2011. Available from: http://hdl.rutgers.edu/1782.1/rucore10001600001.ETD.000061173

University of Lethbridge

15. University of Lethbridge. Faculty of Arts and Science. Patterns of hippocampal amnesia and population activity in rats: Implications for categorical and single-process models of long-term memory organization .

Degree: 2019, University of Lethbridge

URL: http://hdl.handle.net/10133/5402

► Contemporary views on the organization of long-term memory (LTM) suggest the hippocampus is involved in a unique category of LTM. Recent experiments illustrate that hippocampal… (more)

Subjects/Keywords: Hippocampus; Rat; Memory

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APA (6^th Edition):

Science, U. o. L. F. o. A. a. (2019). Patterns of hippocampal amnesia and population activity in rats: Implications for categorical and single-process models of long-term memory organization . (Thesis). University of Lethbridge. Retrieved from http://hdl.handle.net/10133/5402

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Science, University of Lethbridge. Faculty of Arts and. “Patterns of hippocampal amnesia and population activity in rats: Implications for categorical and single-process models of long-term memory organization .” 2019. Thesis, University of Lethbridge. Accessed February 22, 2020. http://hdl.handle.net/10133/5402.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Science, University of Lethbridge. Faculty of Arts and. “Patterns of hippocampal amnesia and population activity in rats: Implications for categorical and single-process models of long-term memory organization .” 2019. Web. 22 Feb 2020.

Vancouver:

Science UoLFoAa. Patterns of hippocampal amnesia and population activity in rats: Implications for categorical and single-process models of long-term memory organization . [Internet] [Thesis]. University of Lethbridge; 2019. [cited 2020 Feb 22]. Available from: http://hdl.handle.net/10133/5402.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Science UoLFoAa. Patterns of hippocampal amnesia and population activity in rats: Implications for categorical and single-process models of long-term memory organization . [Thesis]. University of Lethbridge; 2019. Available from: http://hdl.handle.net/10133/5402

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Cornell University

16. Law, Loren. Contextual Learning In The Limbic Memory Circuit .

Degree: 2015, Cornell University

URL: http://hdl.handle.net/1813/39373

► Context plays a critical role in memory. Information obtained during learning gets bound to the context and the context itself can serve as a potent… (more)

▼ Context plays a critical role in memory. Information obtained during learning gets bound to the context and the context itself can serve as a potent retrieval cue. It has been well known since the 1970's that the hippocampus (HP) plays a critical role in processing contextual information. Research has shown that learning two lists of items in two different contexts facilitates learning compared to learning both in one context, and damage to the HP abolishes this advantage. Electrophysiology studies have indicated the HP forms contextual representations of an environment quickly and that the representation remains stable thereafter. The HP also encodes non-spatial information such as events, cues and time. The HP and AT are strongly interconnected and it is well known now that damage to the anterior thalamic nuclei (AT) produces severe memory deficits in multiple memory domains similar that following damage to the HP. However, it is not known whether the AT is critically involved in contextual memory processes like the HP. The first chapter evaluated whether the AT is involved in contextual learning of a context dependent odor discrimination task. The results showed that like the HP, damage to the AT abolishes the contextual advantage of learning two sets of odor discrimination problems in separate contexts. The second chapter evaluated how neuronal representations in the HP change when learning two contexts concurrently. While studies have evaluated how neuronal representations change between context exposures, none have evaluated the concurrent development of two contexts. The results showed that several exposures to the same context are required to form a stable HP representation of the two contexts. The final iii chapter evaluated what event responses arise when learning the same task as chapter one and how these event representations change with learning. The results show that as learning progressed, event responses decreased in number. This decrease may be due to the responses becoming part of a general trial sequence indicating the stabilization of the representation as learning progressed. The current dissertation provides new evidence for how the memory circuit encodes contextual memory. iv Advisors/Committee Members: Regan, Elizabeth (committeeMember), Devoogd, Timothy John (committeeMember), Cutting, James Eric (committeeMember).

Subjects/Keywords: Context; Hippocampus; elctrophysiology

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Law, L. (2015). Contextual Learning In The Limbic Memory Circuit . (Thesis). Cornell University. Retrieved from http://hdl.handle.net/1813/39373

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Law, Loren. “Contextual Learning In The Limbic Memory Circuit .” 2015. Thesis, Cornell University. Accessed February 22, 2020. http://hdl.handle.net/1813/39373.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Law, Loren. “Contextual Learning In The Limbic Memory Circuit .” 2015. Web. 22 Feb 2020.

Vancouver:

Law L. Contextual Learning In The Limbic Memory Circuit . [Internet] [Thesis]. Cornell University; 2015. [cited 2020 Feb 22]. Available from: http://hdl.handle.net/1813/39373.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Law L. Contextual Learning In The Limbic Memory Circuit . [Thesis]. Cornell University; 2015. Available from: http://hdl.handle.net/1813/39373

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Pennsylvania

17. Wang, Melissa Eveline. The Role of the Hippocampus in Representations of Emotional Memory.

Degree: 2013, University of Pennsylvania

URL: https://repository.upenn.edu/edissertations/940

► Although the hippocampus has long been implicated in contextual fear learning, the exact function of this brain structure is unclear. It is generally thought to… (more)

▼ Although the hippocampus has long been implicated in contextual fear learning, the exact function of this brain structure is unclear. It is generally thought to encode a spatial context with which a fear memory can be associated, but how it may accomplish this and whether it plays a role in emotional memory is largely unknown. It is also unclear whether the hippocampus acts as a single unitary structure, or whether the dorsal and ventral poles, which exhibit differential connectivity to other brain regions, function independently. This dissertation examines the involvement of the hippocampus in emotional learning. A contextual fear conditioning paradigm using a predator odor as an ethologically relevant fearful stimulus was developed and lesions and immunohistochemistry were used to examine differential involvement of the dorsal and ventral hippocampus in response to fear learning. Long-term physiological recordings of dorsal place cells were then conducted to determine the effects of fear conditioning and also fear extinction on contextual representations in the hippocampus. Additionally, cells in the ventral hippocampus were assessed for responses to visuospatial manipulations and changing odor cues of varying emotional valence. It was found that the dorsal and ventral hippocampal regions are both independently required for contextual fear conditioning, and neurons in each region are differentially activated in response to fear learning. Furthermore, place cells in the dorsal hippocampus remapped in response to fear conditioning and stabilized those new fields in the long term. Extinction training caused many place cells to remap once again, suggesting that the dorsal hippocampus encodes varying representations of `fearful' and `safe' contexts. Finally, cells in the ventral hippocampus exhibited stronger responses to anxiogenic contextual cues compared to dorsal cells. In conclusion, these data suggest that the hippocampus is involved in emotional learning and that its function may vary along its longitudinal axis.

Subjects/Keywords: context; dorsal hippocampus; emotion; fear conditioning; hippocampus; ventral hippocampus; Neuroscience and Neurobiology

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Wang, M. E. (2013). The Role of the Hippocampus in Representations of Emotional Memory. (Thesis). University of Pennsylvania. Retrieved from https://repository.upenn.edu/edissertations/940

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Wang, Melissa Eveline. “The Role of the Hippocampus in Representations of Emotional Memory.” 2013. Thesis, University of Pennsylvania. Accessed February 22, 2020. https://repository.upenn.edu/edissertations/940.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Wang, Melissa Eveline. “The Role of the Hippocampus in Representations of Emotional Memory.” 2013. Web. 22 Feb 2020.

Vancouver:

Wang ME. The Role of the Hippocampus in Representations of Emotional Memory. [Internet] [Thesis]. University of Pennsylvania; 2013. [cited 2020 Feb 22]. Available from: https://repository.upenn.edu/edissertations/940.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Wang ME. The Role of the Hippocampus in Representations of Emotional Memory. [Thesis]. University of Pennsylvania; 2013. Available from: https://repository.upenn.edu/edissertations/940

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Dalhousie University

18. McClelland, Christine R. Cux2 regulates neurogenesis in the postnatal mouse hippocampus.

Degree: MS, Department of Anatomy & Neurobiolgy with Neuroscience, 2012, Dalhousie University

URL: http://hdl.handle.net/10222/15237

► Although once thought to be incapable of regeneration, the adult mammalian brain generates new neurons in two regions: the SVZ of the lateral ventricle and… (more)

Subjects/Keywords: Hippocampus; Cux2; adult neurogenesis

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

McClelland, C. R. (2012). Cux2 regulates neurogenesis in the postnatal mouse hippocampus. (Masters Thesis). Dalhousie University. Retrieved from http://hdl.handle.net/10222/15237

Chicago Manual of Style (16^th Edition):

McClelland, Christine R. “Cux2 regulates neurogenesis in the postnatal mouse hippocampus.” 2012. Masters Thesis, Dalhousie University. Accessed February 22, 2020. http://hdl.handle.net/10222/15237.

MLA Handbook (7^th Edition):

McClelland, Christine R. “Cux2 regulates neurogenesis in the postnatal mouse hippocampus.” 2012. Web. 22 Feb 2020.

Vancouver:

McClelland CR. Cux2 regulates neurogenesis in the postnatal mouse hippocampus. [Internet] [Masters thesis]. Dalhousie University; 2012. [cited 2020 Feb 22]. Available from: http://hdl.handle.net/10222/15237.

Council of Science Editors:

McClelland CR. Cux2 regulates neurogenesis in the postnatal mouse hippocampus. [Masters Thesis]. Dalhousie University; 2012. Available from: http://hdl.handle.net/10222/15237

19. Koutsona, Christina. Επίδραση των οπιοειδών στη δραστηριότητα των νευρώνων του ιπποκάμπου.

Degree: 2014, University of Thessaly (UTH); Πανεπιστήμιο Θεσσαλίας

URL: http://hdl.handle.net/10442/hedi/35901

►

The extended research in the structural and functional features of the hippocampus has revealed the differentiation of the dorsal and the ventral hippocampus in terms… (more)

▼

The extended research in the structural and functional features of the hippocampus has revealed the differentiation of the dorsal and the ventral hippocampus in terms of electrophysiological characteristics of the principal neurons, anatomical characteristics of the network and differential role of the neurotransmitters and neuromodulators, including the opioids. Aim of the present study was to investigate the role of the Ih current of the CA1 interneurons in the functional differentiation of the dorsal and the ventral hippocampus and to examine the effect of morphine on this current under current clamp conditions.Intracellular recordings were obtained in vitro from CA1 interneurons of the oriens/alveus border and pyramidal neurons. The interneurons were recognized as such according to electrophysiological criteria. The passive membrane properties of the interneurons of the dorsal and the ventral hippocampus were similar. The response of the interneurons to a sustained hyperpolarizing electrical pulse was different in the dorsal and the ventral hippocampus. The interneurons of the ventral hippocampus showed a stronger hyperpolarization in response to a current pulse of given intensity compared to the interneurons of the dorsal hippocampus, the kinetics of the Ih current seamed to be different and the characteristics of the rebound depolarization were distinct between the two populations. Morphine (30 μΜ) reduced the activation of the Ih current, hyperpolarized the interneurons and changed the characteristics of the rebound depolarization. In one interneuron the drug caused a depolarization of the resting membrane potential and an augmentation of the Ih current. Moreover, morphine decreased the frequency of the spontaneous action potentials at resting membrane potential of the interneurons and the number of the action potentials elicited by a sustained depolarizing pulse.These findings substantiate the hypothesis that the interneurons of the dorsal and the ventral hippocampus may be intrinsically different. Furthermore, they confirm the complexity of the modulatory role of the opioids in the network of the hippocampus and extend the already existing evidence that opioids can reduce the excitability of the interneurons of the dorsal and the ventral hippocampus.

Η διερεύνηση των ανατομικών δομών και των λειτουργιών του ιπποκάμπου έχει αναδείξει τη διαφοροποίηση της κοιλιακής και της ραχιαίας μοίρας του. Διαφορές βρέθηκαν σε επίπεδο λειτουργίας πυραμιδικών νευρώνων και νευρωνικών κυκλωμάτων, καθώς και σε επίπεδο δράσης νευροδιαβιβαστών και νευρορυθμιστών, μεταξύ των οποίων τα οπιοειδή. Σκοπός της παρούσης εργασίας ήταν η διερεύνηση του ρόλου του ρεύματος Ιh των ενδονευρώνων της CA1 περιοχής στη διαφοροποίηση του κοιλιακού και ραχιαίου ιπποκάμπου και της δράσης των οπιοειδών στο ρεύμα αυτό σε συνθήκες καθήλωσης ρεύματος.Διενεργήθηκαν ενδοκυττάριες in vitro καταγραφές με αιχμηρό ηλεκτρόδιο από ενδονευρώνες του ορίου σκάφης/στιβάδας πολυμόρφων κυττάρων και από πυραμιδικούς νευρώνες της CA1 περιοχής. Οι ενδονευρώνες…

Subjects/Keywords: Οπιοειδή; Ιππόκαμπος; Opioids; Hippocampus

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APA (6^th Edition):

Koutsona, C. (2014). Επίδραση των οπιοειδών στη δραστηριότητα των νευρώνων του ιπποκάμπου. (Thesis). University of Thessaly (UTH); Πανεπιστήμιο Θεσσαλίας. Retrieved from http://hdl.handle.net/10442/hedi/35901

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Koutsona, Christina. “Επίδραση των οπιοειδών στη δραστηριότητα των νευρώνων του ιπποκάμπου.” 2014. Thesis, University of Thessaly (UTH); Πανεπιστήμιο Θεσσαλίας. Accessed February 22, 2020. http://hdl.handle.net/10442/hedi/35901.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Koutsona, Christina. “Επίδραση των οπιοειδών στη δραστηριότητα των νευρώνων του ιπποκάμπου.” 2014. Web. 22 Feb 2020.

Vancouver:

Koutsona C. Επίδραση των οπιοειδών στη δραστηριότητα των νευρώνων του ιπποκάμπου. [Internet] [Thesis]. University of Thessaly (UTH); Πανεπιστήμιο Θεσσαλίας; 2014. [cited 2020 Feb 22]. Available from: http://hdl.handle.net/10442/hedi/35901.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Koutsona C. Επίδραση των οπιοειδών στη δραστηριότητα των νευρώνων του ιπποκάμπου. [Thesis]. University of Thessaly (UTH); Πανεπιστήμιο Θεσσαλίας; 2014. Available from: http://hdl.handle.net/10442/hedi/35901

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Ontario Institute of Technology

20. Scott, Gavin A. Sex and seasonal variation in hippocampal volume and neurogenesis in the eastern chipmunk, Tamias striatus.

Degree: 2015, University of Ontario Institute of Technology

URL: http://hdl.handle.net/10155/559

► The hippocampus (HPC) is important in spatial memory and navigation and also exhibits adult neurogenesis. In wild-living species, HPC volume and neurogenesis have been found… (more)

Subjects/Keywords: Hippocampus; Neurogenesis; Doublecortin; Neuroecology; Chipmunk

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APA (6^th Edition):

Scott, G. A. (2015). Sex and seasonal variation in hippocampal volume and neurogenesis in the eastern chipmunk, Tamias striatus. (Thesis). University of Ontario Institute of Technology. Retrieved from http://hdl.handle.net/10155/559

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Scott, Gavin A. “Sex and seasonal variation in hippocampal volume and neurogenesis in the eastern chipmunk, Tamias striatus.” 2015. Thesis, University of Ontario Institute of Technology. Accessed February 22, 2020. http://hdl.handle.net/10155/559.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Scott, Gavin A. “Sex and seasonal variation in hippocampal volume and neurogenesis in the eastern chipmunk, Tamias striatus.” 2015. Web. 22 Feb 2020.

Vancouver:

Scott GA. Sex and seasonal variation in hippocampal volume and neurogenesis in the eastern chipmunk, Tamias striatus. [Internet] [Thesis]. University of Ontario Institute of Technology; 2015. [cited 2020 Feb 22]. Available from: http://hdl.handle.net/10155/559.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Scott GA. Sex and seasonal variation in hippocampal volume and neurogenesis in the eastern chipmunk, Tamias striatus. [Thesis]. University of Ontario Institute of Technology; 2015. Available from: http://hdl.handle.net/10155/559

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Ontario Institute of Technology

21. Gourgouvelis, Joanne. Mechanisms by which exercise promotes hippocampal function in both depressed and non-depressed individuals: A feasibility study.

Degree: 2012, University of Ontario Institute of Technology

URL: http://hdl.handle.net/10155/246

► Depression is one of the top ten health problems in the world, affecting millions of Canadians. Research indicates that exercise is an effective treatment for… (more)

▼ Depression is one of the top ten health problems in the world, affecting millions of Canadians. Research indicates that exercise is an effective treatment for depression but it is not clear on exactly how and why it works. Animal studies show that exercise improves the ability of the brain to function. It can even lead to new cell formation in a part of the brain called the hippocampus, which is important for memory processing. This study is investigating whether exercise may also improve hippocampal function in depressed humans. One way exercise may improve brain function is by normalizing levels of the hormone cortisol, and its toxic effects on the hippocampus. Exercise may also normalize levels of biochemical markers called cytokines involved in inflammation, while improving levels of growth factors important to brain cell function. This feasibility study aimed to develop protocols to investigate changes in hippocampal activity while participants are performing memory tests involving association of images and words in a functional magnetic resonance scanner before and after a 12 week exercise program. It also aimed to develop and validate protocols to measure changes in cortisol, cytokines and growth factors which are likely to be affected by exercise. Our preliminary imaging results revealed hippocampal dysregulation in the depressed brain, and biomarker analysis revealed abnormal concentrations of interleukin-6, vascular endothelial growth factor and salivary cortisol when compared to normal healthy controls. However, following the 12-week exercise program a more normalized pattern of hippocampal activation associated with successful memory encoding was observed. Additionally, biomarker concentrations either resembled or were closer to normal healthy values. Over the long term, the project arising from this feasibility study has the potential to provide a tool to improve exercise prescription, to predict exercise responders and to guide development of combined treatment approaches related to biochemical markers in order to optimize depression outcomes for Canadians. Advisors/Committee Members: Yielder, Paul, Murphy, Bernadette.

Subjects/Keywords: Depression; Exercise; Hippocampus; Memory processing

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APA (6^th Edition):

Gourgouvelis, J. (2012). Mechanisms by which exercise promotes hippocampal function in both depressed and non-depressed individuals: A feasibility study. (Thesis). University of Ontario Institute of Technology. Retrieved from http://hdl.handle.net/10155/246

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Gourgouvelis, Joanne. “Mechanisms by which exercise promotes hippocampal function in both depressed and non-depressed individuals: A feasibility study.” 2012. Thesis, University of Ontario Institute of Technology. Accessed February 22, 2020. http://hdl.handle.net/10155/246.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Gourgouvelis, Joanne. “Mechanisms by which exercise promotes hippocampal function in both depressed and non-depressed individuals: A feasibility study.” 2012. Web. 22 Feb 2020.

Vancouver:

Gourgouvelis J. Mechanisms by which exercise promotes hippocampal function in both depressed and non-depressed individuals: A feasibility study. [Internet] [Thesis]. University of Ontario Institute of Technology; 2012. [cited 2020 Feb 22]. Available from: http://hdl.handle.net/10155/246.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Gourgouvelis J. Mechanisms by which exercise promotes hippocampal function in both depressed and non-depressed individuals: A feasibility study. [Thesis]. University of Ontario Institute of Technology; 2012. Available from: http://hdl.handle.net/10155/246

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Alberta

22. Sharma, Arjun V. Neurosilence: intracerebral applications of protein synthesis inhibitors eliminate neural activity.

Degree: MS, Department of Psychology, 2010, University of Alberta

URL: https://era.library.ualberta.ca/files/47429b262

► The acquisition of a behavioural response (learning) and the later retrieval of this response (memory) are separated by an endogenous biological process which consolidates the… (more)

Subjects/Keywords: memory; cycloheximide; EEG; anisomycin; hippocampus

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APA (6^th Edition):

Sharma, A. V. (2010). Neurosilence: intracerebral applications of protein synthesis inhibitors eliminate neural activity. (Masters Thesis). University of Alberta. Retrieved from https://era.library.ualberta.ca/files/47429b262

Chicago Manual of Style (16^th Edition):

Sharma, Arjun V. “Neurosilence: intracerebral applications of protein synthesis inhibitors eliminate neural activity.” 2010. Masters Thesis, University of Alberta. Accessed February 22, 2020. https://era.library.ualberta.ca/files/47429b262.

MLA Handbook (7^th Edition):

Sharma, Arjun V. “Neurosilence: intracerebral applications of protein synthesis inhibitors eliminate neural activity.” 2010. Web. 22 Feb 2020.

Vancouver:

Sharma AV. Neurosilence: intracerebral applications of protein synthesis inhibitors eliminate neural activity. [Internet] [Masters thesis]. University of Alberta; 2010. [cited 2020 Feb 22]. Available from: https://era.library.ualberta.ca/files/47429b262.

Council of Science Editors:

Sharma AV. Neurosilence: intracerebral applications of protein synthesis inhibitors eliminate neural activity. [Masters Thesis]. University of Alberta; 2010. Available from: https://era.library.ualberta.ca/files/47429b262

University of California – San Diego

23. Diehl, Geoffrey Wainwright. A Role for the Medial Entorhinal Cortex in Multimodal Information Processing and Episodic Memory.

Degree: Neurosciences, 2018, University of California – San Diego

URL: http://www.escholarship.org/uc/item/2585w4dk

► The hippocampus and medial entorhinal cortex (mEC) have been together implicated in the cognitive processes of episodic memory and spatial navigation. Through collective network activity,… (more)

▼ The hippocampus and medial entorhinal cortex (mEC) have been together implicated in the cognitive processes of episodic memory and spatial navigation. Through collective network activity, hippocampal place cells provide a map of the world that could support navigation. In conjunction, remapping in the place cell network provides a mechanism to support episodic memory, allowing for individual episodes to be readily distinguished and reliably recalled. Upstream in mEC, spatial firing patterns are robust, but the ability of mEC cells to remap and provide a signal to support episodic memory has remained largely untested. We recorded mEC cells while altering the features of an explored environment to determine if mEC may play a role in episodic memory processing. Indeed, we observed changes in the firing rates of mEC grid cells and the spatial firing patterns of non-grid spatial cells in response to environment manipulations, indicating that information necessary to distinguish between experiences was contained in mEC network activity. Yet, while distinguishing between events represents a central tenant of episodic memory, an additional requirement is the evaluation of a temporal component. How long ago experiences occur, and in what order, can be just as relevant as what actually happened. Systematic drift in network representations over time represents a candidate mechanism for encoding such temporal information. Drift has been repeatedly observed in the CA1 network, but the origin of such a signal remains unclear. To pursue this question, we recorded CA2 and mEC cells over many hours, evaluating how representations changed, or remained stable, over time. In CA2 we found considerable variation over time, well in excess of that in CA1. Upstream in mEC, a small minority of cells exhibited temporal drift, but overall the representation was reliable, suggesting the primary role of mEC may be to anchor downstream hippocampal representations. Collectively, our work indicates that the conjunctive coding schemes observed in place cells are not unique to the hippocampus, but that upstream the mEC appears to serve a similar role in providing a multimodal representation of an animal’s interactions with the outside world to support both spatial navigation and episodic memory.

Subjects/Keywords: Neurosciences; Hippocampus; Learning; Memory

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APA (6^th Edition):

Diehl, G. W. (2018). A Role for the Medial Entorhinal Cortex in Multimodal Information Processing and Episodic Memory. (Thesis). University of California – San Diego. Retrieved from http://www.escholarship.org/uc/item/2585w4dk

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Diehl, Geoffrey Wainwright. “A Role for the Medial Entorhinal Cortex in Multimodal Information Processing and Episodic Memory.” 2018. Thesis, University of California – San Diego. Accessed February 22, 2020. http://www.escholarship.org/uc/item/2585w4dk.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Diehl, Geoffrey Wainwright. “A Role for the Medial Entorhinal Cortex in Multimodal Information Processing and Episodic Memory.” 2018. Web. 22 Feb 2020.

Vancouver:

Diehl GW. A Role for the Medial Entorhinal Cortex in Multimodal Information Processing and Episodic Memory. [Internet] [Thesis]. University of California – San Diego; 2018. [cited 2020 Feb 22]. Available from: http://www.escholarship.org/uc/item/2585w4dk.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Diehl GW. A Role for the Medial Entorhinal Cortex in Multimodal Information Processing and Episodic Memory. [Thesis]. University of California – San Diego; 2018. Available from: http://www.escholarship.org/uc/item/2585w4dk

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Aberdeen

24. Stoney, Patrick Niall. The roles of Pax6 in neural precursor migration and axon guidance.

Degree: 2009, University of Aberdeen

URL: http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=92509 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.521239

► The ability of migrating neurons and growth cones to navigate through their environment is crucial for the correct development of the brain. Cells and growth… (more)

▼ The ability of migrating neurons and growth cones to navigate through their environment is crucial for the correct development of the brain. Cells and growth cones may be guided by electrical, chemical or topographical cues in their environment. Pax6 is a transcription factor vital for brain development. Pax6-/- mutant mice die perinatally with defects in neuronal proliferation and differentiation, cortical cell migration and axon guidance, yet it is not clear which guidance cues Pax6-/- mutant neurons fail to interpret. Dissociated cultured cells were used to study the cell-autonomous effects of Pax6 mutation on guidance of growth cones and migrating neural precursors by environmental cues. Neurites from mouse embryonic cortical neurons aligned perpendicular to 1 μm-wide, 130 nm-deep substratum grooves. Pax6-/- mutation abolished contact-mediated neurite guidance by these grooves. Laminin induced a switch from perpendicular to parallel alignment to grooves, via a β1 integrin-independent mechanism. Blocking cAMP signalling abolished perpendicular alignment to polylysine-coated grooves, but enhanced parallel alignment to laminin-coated grooves. Pax6 null mutation or overexpression also caused specific defects in contact-guided migration by cortical cells. An electric field applied to E16.5 cortical neurons increased the frequency of extension of neurites aligned perpendicular to the field axis. Pax6-/- mutant cells responded to an electric field with reduced anodal extension, but no significant increase in perpendicular neurite extension. Electrical cues were prioritised over topographical cues when presented in combination. Taken together, data suggest that Pax6 mutant cortical cells do not completely lack the ability to detect extracellular guidance cues, but they respond differently to wild-type cells. In combination with other defects identified in the cortex, this may contribute to the cell migration and axon guidance phenotypes in the brain of the Pax6-/- embryo. This study also identified novel Pax6 expression in the trigeminal ganglion, where it may regulate axon guidance and neurogenesis.

Subjects/Keywords: 573.8; Brain : Neurons : Hippocampus

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APA (6^th Edition):

Stoney, P. N. (2009). The roles of Pax6 in neural precursor migration and axon guidance. (Doctoral Dissertation). University of Aberdeen. Retrieved from http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=92509 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.521239

Chicago Manual of Style (16^th Edition):

Stoney, Patrick Niall. “The roles of Pax6 in neural precursor migration and axon guidance.” 2009. Doctoral Dissertation, University of Aberdeen. Accessed February 22, 2020. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=92509 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.521239.

MLA Handbook (7^th Edition):

Stoney, Patrick Niall. “The roles of Pax6 in neural precursor migration and axon guidance.” 2009. Web. 22 Feb 2020.

Vancouver:

Stoney PN. The roles of Pax6 in neural precursor migration and axon guidance. [Internet] [Doctoral dissertation]. University of Aberdeen; 2009. [cited 2020 Feb 22]. Available from: http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=92509 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.521239.

Council of Science Editors:

Stoney PN. The roles of Pax6 in neural precursor migration and axon guidance. [Doctoral Dissertation]. University of Aberdeen; 2009. Available from: http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=92509 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.521239

University of Edinburgh

25. Langston, Rosamund Fay. Role of the hippocampus in event memory in the rat.

Degree: 2008, University of Edinburgh

URL: http://hdl.handle.net/1842/4141

► This thesis aims to examine the role of the hippocampus in declarative memory through the development of animal behavioural models of episodic memory for laboratory… (more)

▼ This thesis aims to examine the role of the hippocampus in declarative memory through the development of animal behavioural models of episodic memory for laboratory rats. Episodic memory- memory for unique events or episodes- is part of the declarative memory system thought to be mediated by the medial temporal lobe area of the brain in humans. One commonly used test of episodic memory in human subjects is paired associate learning. The first part of this thesis describes the adaptation of this human test for use with laboratory rats. Using their natural foraging tendency, rats were trained to search for different flavours of food at different locations within a large enclosure. When cued with a piece of food of a particular flavour in a separate box, rats learned to return to the place where that flavour of food had previously been found. This paradigm was used to investigate the role of the hippocampus in paired-associate learning using temporary pharmacological inactivation and permanent neurotoxic lesion techniques. The hippocampus has also been strongly implicated in spatial navigation, learning and memory in rats and humans. In the experiments described previously, attempts were therefore made to demonstrate that the results were not confounded by a simple deficit in spatial navigation. An alternative approach to studying episodic memory in the laboratory rat is to use the criteria established by Tulving in 1972 to describe episodic memory. He stated that episodic memory should encompass the memory for an event and the spatiotemporal context in which it occurred, i.e. the ”what”, ”where” and ”when” of an event. He later updated these criteria to include demonstration of autonoetic consciousness- most easily described as a sense of self awareness. Since this is difficult or impossible to demonstrate in animals, the term ”episodic-like” memory was coined (Clayton & Dickinson 1998) to describe the flexible use of information about the spatiotemporal aspects of an event by non-human species. Since it has been difficult to demonstrate the use of time (when) in rats (Bird et al; 2003, Babb & Crystal 2006a), Eacott & Norman (2004) suggested that the ”when” component could be replaced by context; i.e. another element specific to a particular event that they labelled ”which”. The next part of this thesis describes the use of the task published by Eacott & Norman to test episodic-like memory in the laboratory rat. Using the innate spontaneous behaviour of rats to explore novel aspects of their environment, they were exposed to multiple unique events. These consisted of various three-dimensional objects being presented in different locations within different contexts. Their memory for manipulations of the environment was then tested by presenting them with an event in which one combination of object, location and context was different from combinations which had previously been encountered. Due to their tendency to explore novel aspects of their environment, normal rats spent the majority of their time exploring the…

Subjects/Keywords: 612.8; rat; hippocampus; episodic memory

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Langston, R. F. (2008). Role of the hippocampus in event memory in the rat. (Doctoral Dissertation). University of Edinburgh. Retrieved from http://hdl.handle.net/1842/4141

Chicago Manual of Style (16^th Edition):

Langston, Rosamund Fay. “Role of the hippocampus in event memory in the rat.” 2008. Doctoral Dissertation, University of Edinburgh. Accessed February 22, 2020. http://hdl.handle.net/1842/4141.

MLA Handbook (7^th Edition):

Langston, Rosamund Fay. “Role of the hippocampus in event memory in the rat.” 2008. Web. 22 Feb 2020.

Vancouver:

Langston RF. Role of the hippocampus in event memory in the rat. [Internet] [Doctoral dissertation]. University of Edinburgh; 2008. [cited 2020 Feb 22]. Available from: http://hdl.handle.net/1842/4141.

Council of Science Editors:

Langston RF. Role of the hippocampus in event memory in the rat. [Doctoral Dissertation]. University of Edinburgh; 2008. Available from: http://hdl.handle.net/1842/4141

University of New Mexico

26. Gross, Amanda. Lateralization of the developing rat hippocampal formation.

Degree: UNM Biology Department, 2011, University of New Mexico

URL: https://digitalrepository.unm.edu/biol_etds/44

► Differences between the left and right hemisphere of the brain have been observed in humans and rodents (Broca, 1861; Wernicke, 1881), including the hippocampal formation,… (more)

▼ Differences between the left and right hemisphere of the brain have been observed in humans and rodents (Broca, 1861; Wernicke, 1881), including the hippocampal formation, a region of the brain that is necessary for some forms of learning and memory (Olton and Samuelson, 1976; deToledo-Morrell et al., 1988; Bernasconi-Guastalla et al., 1994; Tabibnia et al., 1994; Poe et al., 2000; Lister et al., 2006; Hanlon et al., 2005; Sommer et al., 2005; Moskal et al., 2006; Thompson et al., 2008; Klur et al., 2009). Although lateralization of the hippocampal formation has been studied in the adult, few have sought to directly examine the development of hippocampal lateralization (Moskal et al., 2006) and none have examined hippocampal lateralization in the embryo. The objective of the study outlined in this dissertation was to characterize the development of hippocampal lateralization in the rat. To achieve this objective, a rat CNS microarray with 1,178 genes representing the majority of ontological categories within the rat genome (Kroes et al., 2006) was used to examine lateralized gene expression in the embryonic rat hippocampal formation: 14 genes were all more highly expressed in the right hippocampus at E18 (Gross et al., 2008; Gross et al., 2010). Database for Annotation Visualization and Integrated Discovery (DAVID) and Gene Set Enrichment Analysis (GSEA) were also used to further investigate whether specific genes differentially expressed at E18 comprised pathways known to be important in the development of the hippocampal formation. Results demonstrated that genes related to structure, transcription and translation, cellular metabolism, glycolysis, and gap junction signaling were more highly expressed in the right hippocampus at E18. Expression of genes corresponding to proteins that comprise the gap junction signaling pathway were further examined using qRT-PCR. Results showed that alpha1a-tubulin, beta3-tubulin, and connexin43 were more highly expressed in the right hippocampus at E18. Using Western blot analysis, alpha1a-tubulin protein levels were also shown to be higher in the right hippocampus at E18. These results indicated that genes related to hippocampal growth and development were more highly expressed in the right hippocampus at E18, and furthermore they suggested that gap junctions may play a critical role in the development of hippocampal lateralization in the embryo. To further characterize the lateralized development of the rat hippocampal formation, the effect of N-methyl-D-aspartate glutamate receptor (NMDAR) mediated synaptic activity lateralized gene expression in the hippocampal formation during early postnatal development in the rat. During normal development, the pattern of lateralized gene expression displays a right-to-left shift in preferential expression between P6 and P9 (Moskal et al., 2006). A reduction in NMDA receptor (NMDAR) mediated synaptic activity using the selective NMDAR antagonist CPP, altered this pattern of lateralized gene expression at P9 (Rahimi et al., 2006, Gross et… Advisors/Committee Members: Claiborne, Brenda, Cripps, Richard, Moskal, Joseph, Partridge, Donald, Wilson, Michael.

Subjects/Keywords: development; lateralization; hippocampus; hippocampal formation

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APA (6^th Edition):

Gross, A. (2011). Lateralization of the developing rat hippocampal formation. (Doctoral Dissertation). University of New Mexico. Retrieved from https://digitalrepository.unm.edu/biol_etds/44

Chicago Manual of Style (16^th Edition):

Gross, Amanda. “Lateralization of the developing rat hippocampal formation.” 2011. Doctoral Dissertation, University of New Mexico. Accessed February 22, 2020. https://digitalrepository.unm.edu/biol_etds/44.

MLA Handbook (7^th Edition):

Gross, Amanda. “Lateralization of the developing rat hippocampal formation.” 2011. Web. 22 Feb 2020.

Vancouver:

Gross A. Lateralization of the developing rat hippocampal formation. [Internet] [Doctoral dissertation]. University of New Mexico; 2011. [cited 2020 Feb 22]. Available from: https://digitalrepository.unm.edu/biol_etds/44.

Council of Science Editors:

Gross A. Lateralization of the developing rat hippocampal formation. [Doctoral Dissertation]. University of New Mexico; 2011. Available from: https://digitalrepository.unm.edu/biol_etds/44

University of New Mexico

27. Dietz, Robert. Relative contributions of zinc and calcium to acute injury to hippocampal CA1 neurons.

Degree: Biomedical Sciences Graduate Program, 2010, University of New Mexico

URL: https://digitalrepository.unm.edu/biom_etds/12

► Spreading depression (SD) is a wave of severe depolarization that spreads across brain tissue. For several decades, it has been suggested that (SD) may play… (more)

▼ Spreading depression (SD) is a wave of severe depolarization that spreads across brain tissue. For several decades, it has been suggested that (SD) may play a role in the expansion of brain injury following ischemic insults, and may also be involved in non-injurious pathologies such as migraine aura. The major goals of this study were to examine cellular mechanisms that contribute to the initiation of different forms of SD, and in particular the potential roles of the cations Ca2+ and Zn2+. Work in this thesis examined SD in hippocampal slices acutely prepared from adult mice. Initial studies used the Na+/K+ ATPase inhibitor ouabain to generate SD, and showed that L-type Ca2+ channels are required for initiation of SD, but that Ca2+ influx through these channels was not involved. In fact, from NAD(P)H autofluorescence studies, it was suggested that Ca2+ influx may promote mitochondrial function prior to SD, rather than contribute to ionic deregulation. A combination of imaging approaches was then used to demonstrate that Zn2+ could enter neurons through L-type Ca2+ channels and depolarize the inner mitochondrial membrane prior to SD. Furthermore, chelation of Zn2+ completely prevented SD, showing for the first time that Zn2+ entry could be critically required for SD. It was then shown that very similar ionic mechanisms appeared to be involved in SD generated by oxygen/glucose deprivation (OGD), an in vitro model of ischemia. Zn2+, rather than Ca2+ influx appeared to be critically required for the onset of OGD/SD. SD generated by localized high K+ applications appeared to involve quite distinct ionic mechanisms. Zn2+-dependent mechanisms were not involved, but Ca2+ chelation effectively prevented the propagation of these events. Single-neuron Ca2+ imaging studies showed that high K+/SD resulted in recoverable Ca2+ loads throughout neurons, whereas OGD/SD and ouabain/SD lead to irrecoverably high Ca2+ levels and rapid neuronal injury. These results provide the first evidence that Zn2+ can selectively contribute to SD in pathological models, and suggest novel approaches to mitigating brain injury following stroke. Advisors/Committee Members: Shuttleworth, C. William, Valenzuela, C. Fernando, Resta, Tom, Mueller, Wolfgang.

Subjects/Keywords: Zinc; Calcium; Spreading Depression; Hippocampus

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Dietz, R. (2010). Relative contributions of zinc and calcium to acute injury to hippocampal CA1 neurons. (Doctoral Dissertation). University of New Mexico. Retrieved from https://digitalrepository.unm.edu/biom_etds/12

Chicago Manual of Style (16^th Edition):

Dietz, Robert. “Relative contributions of zinc and calcium to acute injury to hippocampal CA1 neurons.” 2010. Doctoral Dissertation, University of New Mexico. Accessed February 22, 2020. https://digitalrepository.unm.edu/biom_etds/12.

MLA Handbook (7^th Edition):

Dietz, Robert. “Relative contributions of zinc and calcium to acute injury to hippocampal CA1 neurons.” 2010. Web. 22 Feb 2020.

Vancouver:

Dietz R. Relative contributions of zinc and calcium to acute injury to hippocampal CA1 neurons. [Internet] [Doctoral dissertation]. University of New Mexico; 2010. [cited 2020 Feb 22]. Available from: https://digitalrepository.unm.edu/biom_etds/12.

Council of Science Editors:

Dietz R. Relative contributions of zinc and calcium to acute injury to hippocampal CA1 neurons. [Doctoral Dissertation]. University of New Mexico; 2010. Available from: https://digitalrepository.unm.edu/biom_etds/12

University of Newcastle

28. Walsh, Bernard Anthony. The relationship between early Alzheimer’s Disease, Apolipoprotein E genotyping & Hippocampal MRI Volumes.

Degree: MPhil, 2014, University of Newcastle

URL: http://hdl.handle.net/1959.13/1041620

►

Masters Research - Master of Philosophy (MPhil)

This thesis attempts to improve the clinical probability of correctly staging the degree of Alzheimer’s Disease (AD) neuropathology… (more)

Subjects/Keywords: Hippocampus; Alzheimer’s Disease; Apolipoprotein E

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Walsh, B. A. (2014). The relationship between early Alzheimer’s Disease, Apolipoprotein E genotyping & Hippocampal MRI Volumes. (Masters Thesis). University of Newcastle. Retrieved from http://hdl.handle.net/1959.13/1041620

Chicago Manual of Style (16^th Edition):

Walsh, Bernard Anthony. “The relationship between early Alzheimer’s Disease, Apolipoprotein E genotyping & Hippocampal MRI Volumes.” 2014. Masters Thesis, University of Newcastle. Accessed February 22, 2020. http://hdl.handle.net/1959.13/1041620.

MLA Handbook (7^th Edition):

Walsh, Bernard Anthony. “The relationship between early Alzheimer’s Disease, Apolipoprotein E genotyping & Hippocampal MRI Volumes.” 2014. Web. 22 Feb 2020.

Vancouver:

Walsh BA. The relationship between early Alzheimer’s Disease, Apolipoprotein E genotyping & Hippocampal MRI Volumes. [Internet] [Masters thesis]. University of Newcastle; 2014. [cited 2020 Feb 22]. Available from: http://hdl.handle.net/1959.13/1041620.

Council of Science Editors:

Walsh BA. The relationship between early Alzheimer’s Disease, Apolipoprotein E genotyping & Hippocampal MRI Volumes. [Masters Thesis]. University of Newcastle; 2014. Available from: http://hdl.handle.net/1959.13/1041620

University of Southern California

29. Hsiao, Min-Chi. Developing a neural prosthesis for hippocampus: proof-of-concept using the in vitro slice.

Degree: PhD, Biomedical Engineering, 2009, University of Southern California

URL: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll127/id/236331/rec/1900

► We are developing a neural prosthesis that can replace regions of the hippocampal brain area that have been damaged by disease or insult. We used… (more)

▼ We are developing a neural prosthesis that can replace regions of the hippocampal brain area that have been damaged by disease or insult. We used the hippocampal slice preparation as the first step in developing such a prosthesis. The major intrinsic circuitry of the hippocampus consists of an excitatory cascade involving the dentate gyrus (DG), CA3, and CA1 subregions; it can be maintained in a transverse slice preparation. Our goal is to develop a biologically realistic model to replace the CA3 region; as such the model transforms DG signals into the corresponding output signals, reinstating the activity in CA1 region. The path to proof our concept involves: i) developing a slice-prosthesis interface specifically for the trisynaptic pathway, ii) formulating nonlinear neuronal models of the hippocampal trans-synaptic transformation, and iii) designing experimental paradigms to validate our prosthesis model.; In this thesis, a conformal multi-electrode array that spatially matched with the trisynaptic pathway was fabricated and used as the slice-prosthesis interface. The recorded data were used to characterize the hippocampal nonlinear properties using Laguerre-Volterra kernel modeling approach. Two experimental paradigms were developed to validate our in vitro prosthesis model. The first paradigm explicitly replaced CA3 computational function. A CA3 model was built to predict CA3 output based on DG input, and was further implemented into a VLSI device. In the replacement experiment, DG signals transmitted to the VLSI-CA3 model. Output from the VLSI device, which represents the equivalent responses from the CA3, provided the activation of synaptic inputs to the CA1. Results show the propagation of patterns of activity from DG-VLSI-CA1 reproduces the activity observed in DG-CA3-CA1 circuitry.; The second experimental paradigm was developed to optimize our first prosthesis model; it directly controlled CA1 dynamics. A DG-CA1 trajectory model and a CA1 plant model were built, and an inverse CA1 plant model was formulated. The desired CA1 output was first predicted by the DG-CA1 trajectory model and then converted to the desired stimulation through an inverse CA1 plant model. The derived desired stimuli were used to evoke CA1 activity. Results show improved accuracy in CA1 responses using this modeling-control paradigm. Advisors/Committee Members: Berger, Theodore W. (Committee Chair), Song, Dong (Committee Member), Baudry, Michel (Committee Member), D'Argenio, David Z. (Committee Member), Swanson, Larry W. (Committee Member).

Subjects/Keywords: nerual prosthesis; hippocampus; Volterra kernel

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APA (6^th Edition):

Hsiao, M. (2009). Developing a neural prosthesis for hippocampus: proof-of-concept using the in vitro slice. (Doctoral Dissertation). University of Southern California. Retrieved from http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll127/id/236331/rec/1900

Chicago Manual of Style (16^th Edition):

Hsiao, Min-Chi. “Developing a neural prosthesis for hippocampus: proof-of-concept using the in vitro slice.” 2009. Doctoral Dissertation, University of Southern California. Accessed February 22, 2020. http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll127/id/236331/rec/1900.

MLA Handbook (7^th Edition):

Hsiao, Min-Chi. “Developing a neural prosthesis for hippocampus: proof-of-concept using the in vitro slice.” 2009. Web. 22 Feb 2020.

Vancouver:

Hsiao M. Developing a neural prosthesis for hippocampus: proof-of-concept using the in vitro slice. [Internet] [Doctoral dissertation]. University of Southern California; 2009. [cited 2020 Feb 22]. Available from: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll127/id/236331/rec/1900.

Council of Science Editors:

Hsiao M. Developing a neural prosthesis for hippocampus: proof-of-concept using the in vitro slice. [Doctoral Dissertation]. University of Southern California; 2009. Available from: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll127/id/236331/rec/1900

University of Edinburgh

30. Jordan, Graeme R. Investigation of the functional effects of two novel ampakines in the CNS.

Degree: 2007, University of Edinburgh

URL: http://hdl.handle.net/1842/1946

► The ionotropic glutamate AMPA ((R,S)-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) receptor mediates the majority of excitatory transmission in the CNS. AMPA receptors play a crucial role in both basal… (more)

▼ The ionotropic glutamate AMPA ((R,S)-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) receptor mediates the majority of excitatory transmission in the CNS. AMPA receptors play a crucial role in both basal neurotransmission and synaptic plasticity events (such as long-term potentiation, LTP). Compounds that ‘potentiate’ AMPA receptor function (‘Ampakines’) are known to positively modulate glutamatergic AMPA receptor-gated currents, by slowing the deactivation and desensitisation rate of the receptors, in the presence of the endogenous agonist glutamate. Ampakines have been shown to facilitate LTP induction, improve cognition, and as such have potential in the treatment of conditions such as depression and psychoses (schizophrenia). The main aim of this thesis was to investigate the functional actions of two novel Ampakines, Org 26576 and Org 24448, in the mouse brain. The studies described in this thesis were designed to address this and are outlined as follows: 1. Characterisation and validation of an in vivo semi-quantitative model of [14C]-2-deoxyglucose autoradiography in the C57Bl/6J mouse The first study sought to develop and characterise a model of [14C]-2-deoxyglucose autoradiography, to allow measurement of regional alterations in local cerebral glucose use (LCGU) in the mouse CNS. Following intraperitoneal injection of [14C]-2-deoxyglucose in C57Bl/6J mice, the radiolabelled brains were sectioned and exposed to x-ray film. The resultant autoradiograms were semi-quantitatively analysed for relative optical densities in predetermined regions of interest. The baseline LCGU values in different brain regions were found to be consistent with previously published data. The model was also able to replicate the effects of a well-characterised compound, the NMDA receptor antagonist MK-801 (0.5 mg/kg), in respect to functional cerebral changes. Characteristic effects such as prominent increases in LCGU in the limbic system, and decreases in the somatosensory cortex were reproduced in the model. Thus the semi-quantitative [14C]-2-deoxyglucose model was reproducible and accurate and thus could be further used to investigate the effects of the novel Ampakines, Org 26576 and Org 24448, on cerebral function. 2. Investigation into the effects of acute administration of the novel Ampakines Org 26576 and Org 24448 on functional activity in the murine cerebrum Following the establishment of the methodology, regional alterations in LCGU in response to the Ampakines Org 26576 and Org 24448 were investigated using [14C]-2-deoxyglucose autoradiography. Both Org 26576 and Org 24448 produced regionally selective, dose-dependent increases in LCGU in the mouse cerebrum when administered acutely (~1 hr). The compounds displayed similar yet functionally distinct profiles of activation, the highest levels of activation occurred in areas of the limbic system (hippocampus), sensory systems, and various nuclei (raphe nucleus). Their effects were blocked by pre-administration of the potent selective AMPA receptor antagonist, NBQX (10…

Subjects/Keywords: 615.1; cognition; depression; schizophrenia; hippocampus

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Jordan, G. R. (2007). Investigation of the functional effects of two novel ampakines in the CNS. (Doctoral Dissertation). University of Edinburgh. Retrieved from http://hdl.handle.net/1842/1946

Chicago Manual of Style (16^th Edition):

Jordan, Graeme R. “Investigation of the functional effects of two novel ampakines in the CNS.” 2007. Doctoral Dissertation, University of Edinburgh. Accessed February 22, 2020. http://hdl.handle.net/1842/1946.

MLA Handbook (7^th Edition):

Jordan, Graeme R. “Investigation of the functional effects of two novel ampakines in the CNS.” 2007. Web. 22 Feb 2020.

Vancouver:

Jordan GR. Investigation of the functional effects of two novel ampakines in the CNS. [Internet] [Doctoral dissertation]. University of Edinburgh; 2007. [cited 2020 Feb 22]. Available from: http://hdl.handle.net/1842/1946.

Council of Science Editors:

Jordan GR. Investigation of the functional effects of two novel ampakines in the CNS. [Doctoral Dissertation]. University of Edinburgh; 2007. Available from: http://hdl.handle.net/1842/1946

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