subject:(High mobility group box 1 HMGB1 )

NSYSU

1. Wang, Ting-ya. Suppression of High Mobility Group Box-1 (HMGB-1) by RNAi Might Alter the Inflammatory Response During Sepsis.

Degree: Master, Biological Sciences, 2008, NSYSU

URL: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0904108-164845

► High mobility group box 1 (HMGB-1) protein is a non-histone chromosomal protein. As a DNA binding protein, HMGB-1 is involved in the maintenance of nucleosome… (more)

Subjects/Keywords: RNA interference (RNAi); sepsis; cytokine; High mobility group box 1 (HMGB1)

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Wang, T. (2008). Suppression of High Mobility Group Box-1 (HMGB-1) by RNAi Might Alter the Inflammatory Response During Sepsis. (Thesis). NSYSU. Retrieved from http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0904108-164845

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Wang, Ting-ya. “Suppression of High Mobility Group Box-1 (HMGB-1) by RNAi Might Alter the Inflammatory Response During Sepsis.” 2008. Thesis, NSYSU. Accessed January 24, 2021. http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0904108-164845.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Wang, Ting-ya. “Suppression of High Mobility Group Box-1 (HMGB-1) by RNAi Might Alter the Inflammatory Response During Sepsis.” 2008. Web. 24 Jan 2021.

Vancouver:

Wang T. Suppression of High Mobility Group Box-1 (HMGB-1) by RNAi Might Alter the Inflammatory Response During Sepsis. [Internet] [Thesis]. NSYSU; 2008. [cited 2021 Jan 24]. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0904108-164845.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Wang T. Suppression of High Mobility Group Box-1 (HMGB-1) by RNAi Might Alter the Inflammatory Response During Sepsis. [Thesis]. NSYSU; 2008. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0904108-164845

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Manitoba

2. Kashani, Hessam Hassanzadeh. Role of high mobility group box-1 in the pro-fibrotic response of human airway smooth muscle cells.

Degree: Physiology, 2014, University of Manitoba

URL: http://hdl.handle.net/1993/23677

► Asthma is a chronic disorder highlighted by intermittent airway inflammation and characterized by paroxysmal dyspnea and airway hyperresponsiveness (AHR). A key feature of severe asthma… (more)

Subjects/Keywords: high mobility group box-1 (HMGB1); airway smooth muscle; fibrosis; inflammation; airway remodeling; asthma

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APA (6^th Edition):

Kashani, H. H. (2014). Role of high mobility group box-1 in the pro-fibrotic response of human airway smooth muscle cells. (Masters Thesis). University of Manitoba. Retrieved from http://hdl.handle.net/1993/23677

Chicago Manual of Style (16^th Edition):

Kashani, Hessam Hassanzadeh. “Role of high mobility group box-1 in the pro-fibrotic response of human airway smooth muscle cells.” 2014. Masters Thesis, University of Manitoba. Accessed January 24, 2021. http://hdl.handle.net/1993/23677.

MLA Handbook (7^th Edition):

Kashani, Hessam Hassanzadeh. “Role of high mobility group box-1 in the pro-fibrotic response of human airway smooth muscle cells.” 2014. Web. 24 Jan 2021.

Vancouver:

Kashani HH. Role of high mobility group box-1 in the pro-fibrotic response of human airway smooth muscle cells. [Internet] [Masters thesis]. University of Manitoba; 2014. [cited 2021 Jan 24]. Available from: http://hdl.handle.net/1993/23677.

Council of Science Editors:

Kashani HH. Role of high mobility group box-1 in the pro-fibrotic response of human airway smooth muscle cells. [Masters Thesis]. University of Manitoba; 2014. Available from: http://hdl.handle.net/1993/23677

University of Sydney

3. Ullah, MD Ashik. Novel mechanisms of airway inflammation in mouse models of allergen and virus-induced asthma .

Degree: 2014, University of Sydney

URL: http://hdl.handle.net/2123/12830

► Asthma is a heterogeneous disorder encompassing distinct clinical phenotypes thought to be mediated by distinct mechanisms. The Receptor for Advanced Glycation End products (RAGE) is… (more)

Subjects/Keywords: Asthma,; house dust mite (HDM); cockroach (CR); pneumonia virus of mice (PVM); receptor for advanced glycation end products (RAGE); high-mobility group box-1 (HMGB1).

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Ullah, M. A. (2014). Novel mechanisms of airway inflammation in mouse models of allergen and virus-induced asthma . (Thesis). University of Sydney. Retrieved from http://hdl.handle.net/2123/12830

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Ullah, MD Ashik. “Novel mechanisms of airway inflammation in mouse models of allergen and virus-induced asthma .” 2014. Thesis, University of Sydney. Accessed January 24, 2021. http://hdl.handle.net/2123/12830.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Ullah, MD Ashik. “Novel mechanisms of airway inflammation in mouse models of allergen and virus-induced asthma .” 2014. Web. 24 Jan 2021.

Vancouver:

Ullah MA. Novel mechanisms of airway inflammation in mouse models of allergen and virus-induced asthma . [Internet] [Thesis]. University of Sydney; 2014. [cited 2021 Jan 24]. Available from: http://hdl.handle.net/2123/12830.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Ullah MA. Novel mechanisms of airway inflammation in mouse models of allergen and virus-induced asthma . [Thesis]. University of Sydney; 2014. Available from: http://hdl.handle.net/2123/12830

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Queen Mary, University of London

4. Norster, F. A. Investigating the roles of HMGB1 and its receptor, RAGE, in chronic lymphocytic leukaemia.

Degree: PhD, 2018, Queen Mary, University of London

URL: http://qmro.qmul.ac.uk/xmlui/handle/123456789/56404 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.786339

► High plasma levels of inflammatory mediator, high mobility group box protein 1 (HMGB1), and its main receptor, receptor for advanced glycation end products (RAGE), is… (more)

▼ High plasma levels of inflammatory mediator, high mobility group box protein 1 (HMGB1), and its main receptor, receptor for advanced glycation end products (RAGE), is associated with poor prognosis for a variety of cancers, but little is known about this signalling axis in chronic lymphocytic leukaemia (CLL). We have previously determined significantly increased HMGB1 levels in the plasma of CLL patients compared to healthy controls, associated with poor clinical outcome. It is unknown whether the HMGB1-RAGE signalling axis contributes to disease progression and can directly promote CLL B-cell survival by converging with toll-like receptor 9 (TLR9) signalling. Moreover, the role of soluble RAGE (sRAGE), a free extracellular receptor fragment that functions as a decoy receptor in blood plasma, is poorly documented for CLL. The overall aim of my PhD is to (1) determine expression of HMGB1 receptors, RAGE and TLR9, in CLL B-cells and their prognostic significance in patients with CLL; (2) assess global cell-signalling network activation following exogenous HMGB1 treatment and blockade with neutralising anti-RAGE antibody; (3) study the impact of sRAGE in CLL. Lymph node RAGE expression positively correlated with TLR9, Ki67 and ZAP70 - markers of proliferating and aggressive disease. Patients with high lymph node RAGE expression confer inferior overall survival in comparison to patients with low RAGE expression. Further risk stratification of RAGE with Ki67 and ZAP70 lymph node expression increased the prognostic power of RAGE, highlighting a significant interaction between these variables. HMGB1 induced activation and colocalization of RAGE and TLR9 in CLL B-cells. Phosphoproteomic analysis highlights activation of MAPK signalling in primary CLL cells following HMGB1 treatment in vitro for patients with ZAP70 expression. We confirmed increased plasma levels of HMGB1 and surprisingly of sRAGE in CLL patients compared to healthy controls, but not of other RAGE ligand, S100B. Plasma sRAGE levels did not reach a high enough concentration to inflict full HMGB1 inhibition, but RAGE shedding could be induced in vitro by stimulating metalloprotease termed a disintegrin and metalloproteinase domain-containing protein 10 (ADAM10) with ionomycin in RAGE-transfected HEK293 cell line and primary CLL cells, and blocked when ADAM10 was specifically inhibited with GI254023X. In summary, this study demonstrates that overexpression of HMGB1 receptor, RAGE, in CLL lymph nodes is associated with a worse clinical outcome in patients with CLL. HMGB1 activates both RAGE and TLR9 in primary CLL B-cells. sRAGE has a protective effect in CLL by prolonging time to first treatment and sRAGE originates from ectodomain shedding, dependent on ADAM10. We therefore propose that HMGB1 and surface RAGE may play an important role in promoting CLL cell proliferation and cell survival, and plasma sRAGE combined with HMGB1 could be markers of disease monitoring.

Subjects/Keywords: chronic lymphocytic leukaemia; high mobility group box protein 1; disease monitoring.

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Norster, F. A. (2018). Investigating the roles of HMGB1 and its receptor, RAGE, in chronic lymphocytic leukaemia. (Doctoral Dissertation). Queen Mary, University of London. Retrieved from http://qmro.qmul.ac.uk/xmlui/handle/123456789/56404 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.786339

Chicago Manual of Style (16^th Edition):

Norster, F A. “Investigating the roles of HMGB1 and its receptor, RAGE, in chronic lymphocytic leukaemia.” 2018. Doctoral Dissertation, Queen Mary, University of London. Accessed January 24, 2021. http://qmro.qmul.ac.uk/xmlui/handle/123456789/56404 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.786339.

MLA Handbook (7^th Edition):

Norster, F A. “Investigating the roles of HMGB1 and its receptor, RAGE, in chronic lymphocytic leukaemia.” 2018. Web. 24 Jan 2021.

Vancouver:

Norster FA. Investigating the roles of HMGB1 and its receptor, RAGE, in chronic lymphocytic leukaemia. [Internet] [Doctoral dissertation]. Queen Mary, University of London; 2018. [cited 2021 Jan 24]. Available from: http://qmro.qmul.ac.uk/xmlui/handle/123456789/56404 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.786339.

Council of Science Editors:

Norster FA. Investigating the roles of HMGB1 and its receptor, RAGE, in chronic lymphocytic leukaemia. [Doctoral Dissertation]. Queen Mary, University of London; 2018. Available from: http://qmro.qmul.ac.uk/xmlui/handle/123456789/56404 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.786339

University of Western Ontario

5. Lau, Arthur. Cell Death Regulates Injury and Inflammation During Renal Allograft Transplantation.

Degree: 2014, University of Western Ontario

URL: https://ir.lib.uwo.ca/etd/2384

► Renal transplantation invariably results in tissue injury resulting from ischemia reperfusion injury (IRI), inflammation, drug toxicity, and rejection. Tubular epithelial cells (TEC) comprise the majority… (more)

▼ Renal transplantation invariably results in tissue injury resulting from ischemia reperfusion injury (IRI), inflammation, drug toxicity, and rejection. Tubular epithelial cells (TEC) comprise the majority of renal parenchyma and are susceptible to cell death and injury during diverse forms of inflammation, which has direct and indirect effects on long term allograft function. Renal TEC have the unique ability to attenuate inflammation and alloimmune injury through the expression of various mediators of cell death and inflammatory molecules. Inhibition of cell death pathways in renal allografts may influence outcomes of alloimmune responses and graft survival. In this body of investigation, alteration of apoptosis and necroptosis forms of TEC death in vitro, were tested for their ability to extend allograft survival in vivo. Apoptotic death induced by cytotoxic cells during allograft rejection was inhibited by TEC expression of Granzyme B inhibiting serine protease inhibitor-6 (SPI-6) and prolonged graft survival and function. Apoptosis death of TEC can also be initiated during renal IRI and with rejection by pro-inflammatory cytokines through surface death receptors. However, inhibition of TNFα-induced apoptosis in TEC through caspase-8 upregulated the receptor interacting protein kinase 1 and 3 (RIPK1/3)-mediated necroptosis pathway to limit graft survival. However, inhibition of RIPK1/3 necroptotic death during renal IRI and transplantation was able to preserve renal function and promote long term graft survival. Augmented pro-inflammatory effects following necrotic cell death were related to an increased release of high mobility group box 1 (HMGB1). Use of the HMGB1 inhibitor glycyrrhizic acid (GZA) inhibited inflammatory responses in vitro and was able to ameliorate renal IRI. Collectively these studies highlight the importance of endogenous donor kidney factors in regulating inflammatory cell death and subsequently the severity and outcomes of allograft rejection. Regulators of parenchymal cell death in kidney and other solid organs may provide entirely new therapeutic targets for transplantation which will promote long term allograft survival.

Subjects/Keywords: Kidney transplantation; cell death; serine protease inhibitor 6 (SPI-6); receptor interacting protein kinase 3 (RIPK3); high mobility group box 1 (HMGB1); glycyrrhizic acid (GZA); Immune System Diseases; Medical Immunology; Nephrology

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Lau, A. (2014). Cell Death Regulates Injury and Inflammation During Renal Allograft Transplantation. (Thesis). University of Western Ontario. Retrieved from https://ir.lib.uwo.ca/etd/2384

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Lau, Arthur. “Cell Death Regulates Injury and Inflammation During Renal Allograft Transplantation.” 2014. Thesis, University of Western Ontario. Accessed January 24, 2021. https://ir.lib.uwo.ca/etd/2384.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Lau, Arthur. “Cell Death Regulates Injury and Inflammation During Renal Allograft Transplantation.” 2014. Web. 24 Jan 2021.

Vancouver:

Lau A. Cell Death Regulates Injury and Inflammation During Renal Allograft Transplantation. [Internet] [Thesis]. University of Western Ontario; 2014. [cited 2021 Jan 24]. Available from: https://ir.lib.uwo.ca/etd/2384.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Lau A. Cell Death Regulates Injury and Inflammation During Renal Allograft Transplantation. [Thesis]. University of Western Ontario; 2014. Available from: https://ir.lib.uwo.ca/etd/2384

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universidade Nova

6. Nunes, Maria Carlos Cortegaça da Cruz. Modulation of HMGB1 in reactive and irresponsive microglia treated with amyloid-β peptide.

Degree: 2017, Universidade Nova

URL: http://www.rcaap.pt/detail.jsp?id=oai:run.unl.pt:10362/20581

► Neuroinflammation is associated with microglia reactivity in Alzheimer’s disease (AD) in the presence of amyloid-β (Aβ) peptide. Interestingly, expression and activation of the alarmin high… (more)

▼ Neuroinflammation is associated with microglia reactivity in Alzheimer’s disease (AD) in the presence of amyloid-β (Aβ) peptide. Interestingly, expression and activation of the alarmin high mobility group box 1 (HMGB1) were recently associated with neuroinflammation in the aged brain and noticed to contribute to AD pathology. Recent results from our group indicate that Aβ upregulates HMGB1 mRNA in a culture model of reactive microglial cells. Here we aimed to assess the effects of modulating HMGB1 gene expression in young/reactive and aged/irresponsive microglia, when stimulated by Aβ. Therefore, mixed glial cultures were obtained from CD1 mice pups. Microglia were isolated, maintained for 3 (young) or 16 (aged) days in vitro (DIV) and transiently transfected to silence (si) or overexpress (p) HMGB1, respectively. Cells were then treated (or not) with a mixture of Aβ species (1000 nM). We evaluated: autophagy (LC3II/I and Beclin-1); phagocytosis (MFG-E8); phenotypic markers of pro-inflammatory (TLR2/TLR4/NF-kB signalling pathway, NLRP3-inflammasome/IL-18 complex, TNF-α, iNOS and MHCII) or anti-inflammatory (IL-10 and Arginase-1, CX3CR1) stages; inflamma-miRNAs (miR-155, miR-124 and miR-146a); and senescence. Aβ induced HMGB1 expression in 3 DIV/young microglia and promoted autophagy, M1 polarization, as well as senescence, while reducing MFG-E8-associated phagocytosis. Efficient siHMGB1 abrogated all these effects, with exception of NLRP3 mRNA upsurge. Contrarily, Aβ couldn’t trigger HMGB1 upregulation in 16DIV/aged microglia, only achieved in pHMGB1-treated samples. pHMGB1 diminished senescence in Aβ-challenged cells and increased the expression of pro- and anti-inflammatory markers, even in the absence of Aβ challenge. Overall, our data suggest that siHMGB1 protects young microglia from excessive activation without compromising their responsiveness, while pHMGB1 allows aged microglia to regain a reactive profile. Therefore, selective modulation of HMGB1 appears essential to preserve microglia’s key functions, supporting a potential therapeutic application in AD with advantages over conventional broad effect anti-inflammatory agents. Advisors/Committee Members: Brites, Dora, Vaz, Ana.

Subjects/Keywords: Alzheimer’s disease; Amyloid-β peptide; Inflammation; Reactive and aged microglia; High mobility group box 1 modulation; Microglial function and dysfunction; Domínio/Área Científica::Engenharia e Tecnologia::Outras Engenharias e Tecnologias

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APA (6^th Edition):

Nunes, M. C. C. d. C. (2017). Modulation of HMGB1 in reactive and irresponsive microglia treated with amyloid-β peptide. (Thesis). Universidade Nova. Retrieved from http://www.rcaap.pt/detail.jsp?id=oai:run.unl.pt:10362/20581

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Nunes, Maria Carlos Cortegaça da Cruz. “Modulation of HMGB1 in reactive and irresponsive microglia treated with amyloid-β peptide.” 2017. Thesis, Universidade Nova. Accessed January 24, 2021. http://www.rcaap.pt/detail.jsp?id=oai:run.unl.pt:10362/20581.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Nunes, Maria Carlos Cortegaça da Cruz. “Modulation of HMGB1 in reactive and irresponsive microglia treated with amyloid-β peptide.” 2017. Web. 24 Jan 2021.

Vancouver:

Nunes MCCdC. Modulation of HMGB1 in reactive and irresponsive microglia treated with amyloid-β peptide. [Internet] [Thesis]. Universidade Nova; 2017. [cited 2021 Jan 24]. Available from: http://www.rcaap.pt/detail.jsp?id=oai:run.unl.pt:10362/20581.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Nunes MCCdC. Modulation of HMGB1 in reactive and irresponsive microglia treated with amyloid-β peptide. [Thesis]. Universidade Nova; 2017. Available from: http://www.rcaap.pt/detail.jsp?id=oai:run.unl.pt:10362/20581

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

7. ONG SIEW PEI (WANG XIUPEI). THE INTERPLAY OF CELLULAR HOST FACTORS AND VIRAL FACTORS IN MEDIATING VASCULAR PERMEABILITY DURING DENGUE VIRUS INFECTION.

Degree: 2013, National University of Singapore

URL: http://scholarbank.nus.edu.sg/handle/10635/37851

Subjects/Keywords: Dengue virus; endothelial hyperpermeability; endothelial cells; angiopoietin 1; angiopoietin 2; high mobility group box 1

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

XIUPEI), O. S. P. (. (2013). THE INTERPLAY OF CELLULAR HOST FACTORS AND VIRAL FACTORS IN MEDIATING VASCULAR PERMEABILITY DURING DENGUE VIRUS INFECTION. (Thesis). National University of Singapore. Retrieved from http://scholarbank.nus.edu.sg/handle/10635/37851

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

XIUPEI), ONG SIEW PEI (WANG. “THE INTERPLAY OF CELLULAR HOST FACTORS AND VIRAL FACTORS IN MEDIATING VASCULAR PERMEABILITY DURING DENGUE VIRUS INFECTION.” 2013. Thesis, National University of Singapore. Accessed January 24, 2021. http://scholarbank.nus.edu.sg/handle/10635/37851.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

XIUPEI), ONG SIEW PEI (WANG. “THE INTERPLAY OF CELLULAR HOST FACTORS AND VIRAL FACTORS IN MEDIATING VASCULAR PERMEABILITY DURING DENGUE VIRUS INFECTION.” 2013. Web. 24 Jan 2021.

Vancouver:

XIUPEI) OSP(. THE INTERPLAY OF CELLULAR HOST FACTORS AND VIRAL FACTORS IN MEDIATING VASCULAR PERMEABILITY DURING DENGUE VIRUS INFECTION. [Internet] [Thesis]. National University of Singapore; 2013. [cited 2021 Jan 24]. Available from: http://scholarbank.nus.edu.sg/handle/10635/37851.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

XIUPEI) OSP(. THE INTERPLAY OF CELLULAR HOST FACTORS AND VIRAL FACTORS IN MEDIATING VASCULAR PERMEABILITY DURING DENGUE VIRUS INFECTION. [Thesis]. National University of Singapore; 2013. Available from: http://scholarbank.nus.edu.sg/handle/10635/37851

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

8. Dardenne, Adrienne. High Mobility Group Box-1 (HMGB-1) Induces Scar Formation in Early Fetal Wounds.

Degree: MS, Comparative and Veterinary Medicine, 2012, The Ohio State University

URL: http://rave.ohiolink.edu/etdc/view?acc_num=osu1336692891

► Previous studies have shown that inflammation is a key factor in determining scar formation in cutaneous fetal wounds. In a fetal mouse model, sterile… (more)

▼ Previous studies have shown that inflammation is a key factor in determining scar formation in cutaneous fetal wounds. In a fetal mouse model, sterile wounds generated on embryonic day 15 (E15) have little to no inflammation and heal scarlessly, while wounds generated on embryonic day 18 (E18) have inflammation and heal with a scar. The mechanisms leading to age-related differences in inflammation and healing are not fully understood. Alarmins, which comprise a group of endogenous danger signals, have been implicated in promoting inflammation in various organ systems and disease processes. This study evaluates the role of a specific alarmin, high mobility group box 1 (HMGB-1), in cutaneous fetal wound healing. HMGB-1 is a non-histone architectural DNA binding protein localized within the nucleus of the cell. However, it can be released by both passive and active mechanisms. Passive release into the extracellular matrix occurs as a result of cell injury or necrosis. While active secretion is described as a capability of several cell types, including immune cells. Once in the extracellular space, HMGB-1 stimulates inflammation by binding to RAGE (receptor for advanced glycation end products) or toll-like receptors present on inflammatory cells. This is the first study to evaluate the role of HMGB-1 in the process of fetal wound healing. We hypothesized that alterations in the expression or release of HMGB-1 between early and late gestation fetal wounds contribute to the differences seen in healing outcomes. To begin, comparisons of HMGB-1 expression in fetal wounds that heal scarlessly and wounds that heal by scar formation were made. Later experiments tested the ability of HMGB-1 to induce scar formation in E15 wounds that have previously been shown to heal scarlessly. Finally, mechanisms of action were explored to decipher how HMGB-1 affects fibroblasts, the cells ultimately responsible for scar formation. Immunohistochemical staining of E15 and E18 skin revealed age-related differences in HMGB-1 expression patterns in both unwounded and wounded skin. As compared to E15 basal keratinocytes, basal keratinocytes of E18 skin expressed higher nuclear HMGB-1 staining and demonstrated a more substantial loss of nuclear staining after injury, suggesting that HMGB-1 is released to a greater extent in E18 wounds. Furthermore, E15 wounds treated with HMGB-1 could be induced to heal by fibrosis with differences seen in both the amount and quality of collagen present within the scar. Age-dependent differential release of HMGB-1 from fetal keratinocytes during wound healing and the capability of HMGB-1 to induce scar formation in E15 wounds that naturally heal scarlessly were found. These results support the hypothesis that alterations in expression or release of HMGB-1 contribute to the difference seen in healing outcome between early and late fetal wounds. This study suggests both the timing and degree of extracellular HMGB-1 release are potential factors in determining whether scarless or fibrotic… Advisors/Committee Members: Wilgus, Traci (Advisor).

Subjects/Keywords: Biomedical Research; Medicine; high mobility group box 1; HMGB-1; fetal wound healing

…6 High Mobility Group Box 1 (HMGB-‐1)… …healing is used to evaluate high mobility group box 1 (HMGB-1) as the stimulus of… …HMGB-1, in wound healing. High Mobility Group Box 1 (HMGB-1) Initially, HMGB-1 was… …vi Chapter 1: Introduction… …1 Mature Wound Healing…

10 more images…

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APA (6^th Edition):

Dardenne, A. (2012). High Mobility Group Box-1 (HMGB-1) Induces Scar Formation in Early Fetal Wounds. (Masters Thesis). The Ohio State University. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=osu1336692891

Chicago Manual of Style (16^th Edition):

Dardenne, Adrienne. “High Mobility Group Box-1 (HMGB-1) Induces Scar Formation in Early Fetal Wounds.” 2012. Masters Thesis, The Ohio State University. Accessed January 24, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=osu1336692891.

MLA Handbook (7^th Edition):

Dardenne, Adrienne. “High Mobility Group Box-1 (HMGB-1) Induces Scar Formation in Early Fetal Wounds.” 2012. Web. 24 Jan 2021.

Vancouver:

Dardenne A. High Mobility Group Box-1 (HMGB-1) Induces Scar Formation in Early Fetal Wounds. [Internet] [Masters thesis]. The Ohio State University; 2012. [cited 2021 Jan 24]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=osu1336692891.

Council of Science Editors:

Dardenne A. High Mobility Group Box-1 (HMGB-1) Induces Scar Formation in Early Fetal Wounds. [Masters Thesis]. The Ohio State University; 2012. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=osu1336692891

9. Kotsiou, Ourania. Προσδιορισμός της συγκέντρωσης των αλαρμινών HMGB1 και IL33 καθώς και των υποδοχέων τους sRAGEs και sST2 αντίστοιχα, στο πλευριτικό υγρό ασθενών με υπεζωκοτική συλλογή ποικίλης αιτιολογίας.

Degree: 2018, University of Thessaly (UTH); Πανεπιστήμιο Θεσσαλίας

URL: http://hdl.handle.net/10442/hedi/42686

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Interleukin 33 (IL-33) is a nuclear cytokine from the IL-1 family which is constitutively highly expressed in barrier sites, acting via the suppression of tumorigenicity… (more)

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Interleukin 33 (IL-33) is a nuclear cytokine from the IL-1 family which is constitutively highly expressed in barrier sites, acting via the suppression of tumorigenicity 2 (ST2) receptor. On the other hand, high-mobility group box 1 protein (HMGB1) is a chromosomal multifunctional redox sensitive protein. Many actions of HMGB1 are mediated through the receptor for advanced glycation endproducts (RAGE). Both molecules serve various roles in different cellular compartments. Extracellularly, they act as alarmins with multiple roles in immunity and cell homeostasis. Productions of IL-33, HMGB1 and soluble forms of the receptors (sST2 and sRAGE, respectively) have been implicated in several pulmonary diseases. Both axes have been scarcely investigated in pleural diseases. The aims of this thesis were to determine the levels of IL-33 and sST2 as well as ΗΜGB1 and sRAGE in transudative (TrPEs), malignant (MPEs) and parapneumonic (PPEs) pleural effusions (PEs) and investigate the effect of PE fluids with low and high IL-33 or HMGB1 levels on MeT-5A cell adhesion, migration and sphere formation. Further, recombinant IL-33 and HMGB1 were separately used to assess effects on MeT-5A adhesion, migration and sphere formation. IL-33 and sST2 levels were similar among TrPEs, MPEs and PPEs. However, HMGB1 and sRAGE levels were significantly higher and lower, respectively in exudative pleural effusions compared to TrPEs. HMGB1 and sRAGE levels can effectively discriminate transudates from exudates. Remarkably, HMGB1 and sRAGE levels are differentiated between various PEs in an age-dependent manner. A significant positive correlation was found between IL-33 and LDH in TrPEs and between IL-33 and red blood cells (RBCs) in MPEs, while sST2 correlated with lymphocytes in TrPEs. HMGB1 was positively correlated with RBCs and lymphocytes in MPEs. No correlation was found between sRAGE and cellular or specific biochemical characteristics of PEs. Furthermore, we found that in exudates (MPEs and PPEs) high or low levels of IL-33 had significant differential effects on MeT-5A adhesion and migration, while no effect in both cell 33 phenotypes was determined for TrPEs. Further, based on etiology high or low levels of HMGB1 have differential effects on mesothelial cell adhesion, migration and sphere formation. Moreover, significantly decreased MeT-5A cell migration was found when higher concentrations of recombinant IL-33 were used. 50 ng/mL and 100ng/mL of recombinant HMGB1 significantly decreased cell adhesion and sphere size, respectively. These results highlight the emerging role of the IL-33/ST2 and HMGB1/sRAGE axes in pathophysiology of pleural disease. However, further research to improve our understanding of both signaling pathways in pleural homeostasis and disease will be essential to translate aforementioned findings into clinical practice and be able to predict benefits and risks of evolving therapies.

Τόσο η ιντερλευκίνη (IL)-33 όσο και η η πρωτεΐνη υψηλής κινητικότητας της ομάδας Β1 (HMGB1) συνιστούν πολυλειτουργικές πρωτεΐνες που…

Subjects/Keywords: Αλαρμίνη; Ιντερλευκίνη 33; Κυτταρική μετανάστευση; Κυτταρική προσκόλληση; Μεσοθήλιο; Πρωτεΐνη υψηλής κινητικότητας ομάδας Β1; Σφαιροειδές; Υποδοχέας καταστολής της ογκογένεσης 2; Υποδοχέας τελικών προϊόντων προχωρημένης μη ενζυματικής γλυκοζυλίωσης; Alarmin; Cell adhesion; Cell migration; High mobility group box 1 protein; Interleukin 33; Mesothelial; Pleural effusion; Sphere formation; sRAGE; sST2

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Kotsiou, O. (2018). Προσδιορισμός της συγκέντρωσης των αλαρμινών HMGB1 και IL33 καθώς και των υποδοχέων τους sRAGEs και sST2 αντίστοιχα, στο πλευριτικό υγρό ασθενών με υπεζωκοτική συλλογή ποικίλης αιτιολογίας. (Thesis). University of Thessaly (UTH); Πανεπιστήμιο Θεσσαλίας. Retrieved from http://hdl.handle.net/10442/hedi/42686

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Kotsiou, Ourania. “Προσδιορισμός της συγκέντρωσης των αλαρμινών HMGB1 και IL33 καθώς και των υποδοχέων τους sRAGEs και sST2 αντίστοιχα, στο πλευριτικό υγρό ασθενών με υπεζωκοτική συλλογή ποικίλης αιτιολογίας.” 2018. Thesis, University of Thessaly (UTH); Πανεπιστήμιο Θεσσαλίας. Accessed January 24, 2021. http://hdl.handle.net/10442/hedi/42686.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Kotsiou, Ourania. “Προσδιορισμός της συγκέντρωσης των αλαρμινών HMGB1 και IL33 καθώς και των υποδοχέων τους sRAGEs και sST2 αντίστοιχα, στο πλευριτικό υγρό ασθενών με υπεζωκοτική συλλογή ποικίλης αιτιολογίας.” 2018. Web. 24 Jan 2021.

Vancouver:

Kotsiou O. Προσδιορισμός της συγκέντρωσης των αλαρμινών HMGB1 και IL33 καθώς και των υποδοχέων τους sRAGEs και sST2 αντίστοιχα, στο πλευριτικό υγρό ασθενών με υπεζωκοτική συλλογή ποικίλης αιτιολογίας. [Internet] [Thesis]. University of Thessaly (UTH); Πανεπιστήμιο Θεσσαλίας; 2018. [cited 2021 Jan 24]. Available from: http://hdl.handle.net/10442/hedi/42686.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Kotsiou O. Προσδιορισμός της συγκέντρωσης των αλαρμινών HMGB1 και IL33 καθώς και των υποδοχέων τους sRAGEs και sST2 αντίστοιχα, στο πλευριτικό υγρό ασθενών με υπεζωκοτική συλλογή ποικίλης αιτιολογίας. [Thesis]. University of Thessaly (UTH); Πανεπιστήμιο Θεσσαλίας; 2018. Available from: http://hdl.handle.net/10442/hedi/42686

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Louisiana State University

10. Smith, Mathew Damien. Investigating the Role of TORC1 and the Transcription Factor Sfp1p in the Regulation of HMO1 Gene in Saccharomyces cerevisiae.

Degree: MS, Cell Biology, Louisiana State University

URL: https://digitalcommons.lsu.edu/gradschool_theses/5070

► HMGB proteins are eukaryotic, chromatin-associated proteins that play roles in both DNA dynamics and transcription regulation. Hmo1p is an HMGB protein in Saccharomyces cerevisiae… (more)

▼ HMGB proteins are eukaryotic, chromatin-associated proteins that play roles in both DNA dynamics and transcription regulation. Hmo1p is an HMGB protein in Saccharomyces cerevisiae that behaves somewhat like a hybrid between mammalian HMGB proteins and the metazoan linker histone H1. mTORC1, a protein complex containing the Tor1p kinase and a major regulator of cellular growth, is inhibited by both rapamycin and stress. It has also been shown to not only associate with Hmo1p at various gene promoters, but also regulate the HMO1 gene itself through direct binding. In this study, the Hmo1p-mTORC1 relationship was further investigated through two questions: 1) Does the transcription factor Sfp1p play a role in relaying mTORC1’s signal to the HMO1 promoter, and 2) Is the reduction in HMO1 transcripts during stress dependent on mTORC1? Gene expression analyses revealed that Sfp1p is not required for normal HMO1 transcription; however, it does appear to play a role in transmitting the mTORC1 stress signal to the promoter, as transcripts are only significantly decreased during stress when Sfp1p is present. Survival tests revealed that Sfp1p might be hindering the cell’s ability to repair DNA double-strand breaks, as there is a slight increase in cell survival during double-strand break-induction when Sfp1p is knocked-out; however, there is some uncertainty as to whether this is Hmo1p-related. Chromatin Immunoprecipitation techniques were then used to demonstrate that RNA polymerase II is evicted from the HMO1 gene over the course of one hour during stress when Tor1p is knocked-out. This same phenomenon had previously been shown in wild-type cells; however, HMO1 transcripts are only attenuated in wild-type cells, and not when Tor1p is knocked-out. This suggests that mTORC1 is responsible for the reduction of HMO1 mRNA during stress. We propose the possibility that mTORC1 is participating in active mRNA degradation at the HMO1 gene, and that transcription-inhibition techniques can be utilized to confirm this.

Subjects/Keywords: yeast; high mobility group box proteins; double-strand breaks; mechanistic target of rapamycin complex 1

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Smith, M. D. (n.d.). Investigating the Role of TORC1 and the Transcription Factor Sfp1p in the Regulation of HMO1 Gene in Saccharomyces cerevisiae. (Masters Thesis). Louisiana State University. Retrieved from https://digitalcommons.lsu.edu/gradschool_theses/5070

Note: this citation may be lacking information needed for this citation format:
No year of publication.

Chicago Manual of Style (16^th Edition):

Smith, Mathew Damien. “Investigating the Role of TORC1 and the Transcription Factor Sfp1p in the Regulation of HMO1 Gene in Saccharomyces cerevisiae.” Masters Thesis, Louisiana State University. Accessed January 24, 2021. https://digitalcommons.lsu.edu/gradschool_theses/5070.

Note: this citation may be lacking information needed for this citation format:
No year of publication.

MLA Handbook (7^th Edition):

Smith, Mathew Damien. “Investigating the Role of TORC1 and the Transcription Factor Sfp1p in the Regulation of HMO1 Gene in Saccharomyces cerevisiae.” Web. 24 Jan 2021.

Note: this citation may be lacking information needed for this citation format:
No year of publication.

Vancouver:

Smith MD. Investigating the Role of TORC1 and the Transcription Factor Sfp1p in the Regulation of HMO1 Gene in Saccharomyces cerevisiae. [Internet] [Masters thesis]. Louisiana State University; [cited 2021 Jan 24]. Available from: https://digitalcommons.lsu.edu/gradschool_theses/5070.

Note: this citation may be lacking information needed for this citation format:
No year of publication.

Council of Science Editors:

Smith MD. Investigating the Role of TORC1 and the Transcription Factor Sfp1p in the Regulation of HMO1 Gene in Saccharomyces cerevisiae. [Masters Thesis]. Louisiana State University; Available from: https://digitalcommons.lsu.edu/gradschool_theses/5070

Note: this citation may be lacking information needed for this citation format:
No year of publication.

11. Lamiable, Olivier. Identification et caractérisation des partenaires protéiques de DSP1 chez Drosophila melanogaster : Identification and characterization of DSP1 protein partners in drosophila embryo.

Degree: Docteur es, Biologie cellulaire et moléculaire, 2010, Université d'Orléans

URL: http://www.theses.fr/2010ORLE2005

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Chez les eucaryotes pluricellulaires, la différenciation des cellules repose en partie sur l’activation oula répression des gènes. Les profils d’expression génique mis en place vont… (more)

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Chez les eucaryotes pluricellulaires, la différenciation des cellules repose en partie sur l’activation oula répression des gènes. Les profils d’expression génique mis en place vont perdurer d’une générationcellulaire à l’autre. Ce phénomène met en jeu des mécanismes épigénétiques qui remodèlentlocalement la structure de la chromatine. Chez Drosophila melanogaster, les protéines des groupesPolycomb (PcG) et Trithorax (TrxG) participent au maintien du profil d’expression des gènes au coursdu développement. Les protéines PcG maintiennent les gènes réprimés tandis que les protéines TrxGmaintiennent les gènes activés. Une troisième classe de protéines nommée Enhancers of Trithoraxand Polycomb (ETP) module l’activité des PcG et TrxG. Dorsal Switch Protein 1 (DSP1) est uneprotéine HMGB (High Mobility Group B) classée comme une ETP. Par tamisage moléculaire, nousavions montré que la protéine DSP1 était présente au sein de complexes de poids moléculaire de 100kDa à 1 MDa. Le travail de thèse présenté ici a pour but d’identifier les partenaires de la protéineDSP1 dans l’embryon et de mieux connaître les propriétés biochimiques de DSP1. Premièrement, j’aimis en place puis effectué l’immunopurification des complexes contenant DSP1 dans des extraitsprotéiques embryonnaires. Cette approche nous a permis d’identifier 23 partenaires putatifs de laprotéine DSP1. Parmi ces protéines, nous avons identifié la protéine Rm62 qui est une ARN hélicaseà boîte DEAD. Les relations biologiques entre DSP1 et Rm62 ont été précisées. Deuxièmement, j’aidéterminé, par une approche biochimique, de nouvelles caractéristiques physico-chimiques de laprotéine DSP1.

In multicellular organism, the identity of cell is determined by several factors playing on genesexpression. Once established, the gene expression pattern is transmitted to daughter cells through aprocess involving epigenetic mechanisms that locally reshape the structure of chromatin. In Drosophilamelanogaster, the Polycomb (PcG) and trithorax (trxG) group genes are involved in the maintenanceof gene expression profile during development. Inside multimeric complexes, PcG proteins maintaingenes in repressed state whereas TrxG maintain genes active. A third class of proteins, calledEnhancers of Trithorax and Polycomb, regulate PcG and TrxG activities. Dorsal Switch Protein 1(DSP1) is a High Mobility Group B protein acting as an ETP. But DSP1 has not yet been identified inPcG or TrxG complexes. On the basis of gel filtration analysis of protein complexes in embryo nuclearextracts, it appears that the majority of DSP1 is present in complex(es) from 100 kDa to 1MDa. Aimsof present work are the identification of DSP1 protein partners in drosophila embryo and thecharacterization of biochemical properties of DSP1. Firstly, I used immunopurification from drosophilaembryonic nuclear extracts. The proteins purified with DSP1 were characterized through sequencingof peptides from individual protein bands by mass spectrometry. Among identified proteins, wefocused on the DEAD Box RNA helicase, Rm62. The…

Advisors/Committee Members: Locker, Daniel (thesis director), Decoville, Martine (thesis director).

Subjects/Keywords: High Mobility Group; Dorsal Switch Protein 1 (DSP1); Enhancers of Trithorax and Polycomb; Complexe multiprotéique; High Mobility Group; Dorsal Switch Protein 1 (DSP1); Enhancers of Trithorax and Polycomb; Protein complex

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Lamiable, O. (2010). Identification et caractérisation des partenaires protéiques de DSP1 chez Drosophila melanogaster : Identification and characterization of DSP1 protein partners in drosophila embryo. (Doctoral Dissertation). Université d'Orléans. Retrieved from http://www.theses.fr/2010ORLE2005

Chicago Manual of Style (16^th Edition):

Lamiable, Olivier. “Identification et caractérisation des partenaires protéiques de DSP1 chez Drosophila melanogaster : Identification and characterization of DSP1 protein partners in drosophila embryo.” 2010. Doctoral Dissertation, Université d'Orléans. Accessed January 24, 2021. http://www.theses.fr/2010ORLE2005.

MLA Handbook (7^th Edition):

Lamiable, Olivier. “Identification et caractérisation des partenaires protéiques de DSP1 chez Drosophila melanogaster : Identification and characterization of DSP1 protein partners in drosophila embryo.” 2010. Web. 24 Jan 2021.

Vancouver:

Lamiable O. Identification et caractérisation des partenaires protéiques de DSP1 chez Drosophila melanogaster : Identification and characterization of DSP1 protein partners in drosophila embryo. [Internet] [Doctoral dissertation]. Université d'Orléans; 2010. [cited 2021 Jan 24]. Available from: http://www.theses.fr/2010ORLE2005.

Council of Science Editors:

Lamiable O. Identification et caractérisation des partenaires protéiques de DSP1 chez Drosophila melanogaster : Identification and characterization of DSP1 protein partners in drosophila embryo. [Doctoral Dissertation]. Université d'Orléans; 2010. Available from: http://www.theses.fr/2010ORLE2005

Université de Montréal

12. Louvier, Elodie. Conception et évaluation d’un nouveau système de transfection ciblée, basé sur l’utilisation du système E/Kcoil.

Degree: 2015, Université de Montréal

URL: http://hdl.handle.net/1866/13031

Subjects/Keywords: Transfection ciblée; Transfection transitoire; Protéine recombinante; Système E/Kcoil; Vecteur non viral; High mobility group protein-1 (HMGB1); Récepteur Cluster de différenciation 4 (CD4); Sulfatation membranaire; Chlorate de sodium (NaClO3); Targeted transfection; Transient transfection; Recombinant protein; E/Kcoil system; Non-viral vector; High mobility group protein-1 (HMGB1); Cluster of differentiation 4 receptor (CD4); Sulfated membrane; Sodium chlorate (NaClO3); Biology - Cell / Biologie - Cellule (UMI : 0379)

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Louvier, E. (2015). Conception et évaluation d’un nouveau système de transfection ciblée, basé sur l’utilisation du système E/Kcoil. (Thesis). Université de Montréal. Retrieved from http://hdl.handle.net/1866/13031

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Louvier, Elodie. “Conception et évaluation d’un nouveau système de transfection ciblée, basé sur l’utilisation du système E/Kcoil.” 2015. Thesis, Université de Montréal. Accessed January 24, 2021. http://hdl.handle.net/1866/13031.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Louvier, Elodie. “Conception et évaluation d’un nouveau système de transfection ciblée, basé sur l’utilisation du système E/Kcoil.” 2015. Web. 24 Jan 2021.

Vancouver:

Louvier E. Conception et évaluation d’un nouveau système de transfection ciblée, basé sur l’utilisation du système E/Kcoil. [Internet] [Thesis]. Université de Montréal; 2015. [cited 2021 Jan 24]. Available from: http://hdl.handle.net/1866/13031.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Louvier E. Conception et évaluation d’un nouveau système de transfection ciblée, basé sur l’utilisation du système E/Kcoil. [Thesis]. Université de Montréal; 2015. Available from: http://hdl.handle.net/1866/13031

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of California – San Diego

13. Abewe, Hosiana. The role of high mobility group AT- hook 1 (HMGA1) gene expression in HIV reactivation.

Degree: Chemistry, 2017, University of California – San Diego

URL: http://www.escholarship.org/uc/item/23v90858

► In the present era of combination anti-retroviral therapy (ART), the latent cellular reservoir of HIV is recognized as the major barrier to a cure. HIV… (more)

▼ In the present era of combination anti-retroviral therapy (ART), the latent cellular reservoir of HIV is recognized as the major barrier to a cure. HIV latency may be reversed by a controlled induction of virus reactivation in the presence of ART to reveal latently infected cells for immune system recognition and destruction. Histone deacetylase inhibitors (HDACis) have been used as potential latency reversing agents for HIV. Suberoylanilide hydroxamic acid (SAHA), the most widely tested HDACi, has effectively induced expression of HIV RNA in patients on suppressive ART, but has failed to reduce the size of the latent reservoir. The secondary effects of SAHA on host gene and protein expression are among the possible explanations of why SAHA has failed to deplete the latent reservoirs. SAHA upregulates the high mobility group AT-hook 1 (HMGA1) gene, which encodes a protein that represses reporter transcription from HIV promoter, long terminal repeat (LTR) in primary CD4 T cells. In this thesis study, we investigated the role of HMGA1 in HIV reactivation by SAHA. Latently infected CD4 T cells from 11 different blood donors were generated through in vitro model of HIV latency and were each treated with 1uM SAHA or its solvent dimethyl sulfoxide (DMSO). The expression of HMGA1 and HIV reactivation were assessed using droplet digital PCR (ddPCR). The degree of HMGA1 upregulation by SAHA negatively correlated with levels of HIV reactivation. Knockdown experiments were conducted using GapmeR technology in primary CD4 T cells. HMGA1 GampeRs were used to test whether HMGA1 played a role in HIV reactivation by SAHA. Latently infected CD4 T cells from 5 seronegative blood donors were generated through in vitro model of HIV latency and were each treated with 1 uM SAHA or DMSO. The expression of HMGA1 and HIV multiply spliced transcripts was measured using ddPCR. Although, a modest knockdown of HMGA1 was achieved, the improvement of HIV reactivation by SAHA in three samples suggested that HMGA1 presents a potential target for improvement of HIV reactivation by SAHA. However, further studies that optimize HMGA1 knockdown are needed to fully understand the role of HMGA1 in HIV reactivation by SAHA.

Subjects/Keywords: Biochemistry; anti-retroviral therapy (ART); high mobility group AT- hook 1 (HMGA1); Histone deacetylase inhibitors (HDACis); Suberoylanilide hydroxamic acid (SAHA)

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Abewe, H. (2017). The role of high mobility group AT- hook 1 (HMGA1) gene expression in HIV reactivation. (Thesis). University of California – San Diego. Retrieved from http://www.escholarship.org/uc/item/23v90858

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Abewe, Hosiana. “The role of high mobility group AT- hook 1 (HMGA1) gene expression in HIV reactivation.” 2017. Thesis, University of California – San Diego. Accessed January 24, 2021. http://www.escholarship.org/uc/item/23v90858.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Abewe, Hosiana. “The role of high mobility group AT- hook 1 (HMGA1) gene expression in HIV reactivation.” 2017. Web. 24 Jan 2021.

Vancouver:

Abewe H. The role of high mobility group AT- hook 1 (HMGA1) gene expression in HIV reactivation. [Internet] [Thesis]. University of California – San Diego; 2017. [cited 2021 Jan 24]. Available from: http://www.escholarship.org/uc/item/23v90858.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Abewe H. The role of high mobility group AT- hook 1 (HMGA1) gene expression in HIV reactivation. [Thesis]. University of California – San Diego; 2017. Available from: http://www.escholarship.org/uc/item/23v90858

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

14. Kalisch, Thomas. Caractérisation fonctionnelle et biochimique d'un nouveau partenaire de la poly(ADP-ribose) polymérase I : high-mobility group protein containing 2-like 1 : Biochemical and functionnal characterization of a new partner of poly(ADP-ribose) polymerase I : high-mobility group containing protein 2-like 1.

Degree: Docteur es, Aspects moléculaires et cellulaires de la biologie, 2013, Université de Strasbourg

URL: http://www.theses.fr/2013STRAJ068

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La poly(ADP-ribosyl)ation est une modification post-traductionnelle des protéines catalysée par une famille d’enzymes : les poly(ADP-ribose) polymérases. Parmi les plus étudiées, PARP-1 et PARP-2 interviennent… (more)

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La poly(ADP-ribosyl)ation est une modification post-traductionnelle des protéines catalysée par une famille d’enzymes : les poly(ADP-ribose) polymérases. Parmi les plus étudiées, PARP-1 et PARP-2 interviennent dans l’organisation, l’expression et le maintien de l’intégrité du génome. Nous avons initié l'étude d'un nouveau partenaire de PARP-1 préalablement identifié par double-hybride, et encore peu étudié à ce jour : HMG2L1 (High-Mobility Group protein 2 Like-1). La protéine humaine de 601 acides aminés contient un domaine HMG (High-Mobility Group) normalement impliqué dans l’interaction avec l’ADN. Quelques études ont montré que HMG2L1 régule la transcription en agissant comme co-régulateur négatif ou positif. Dans un premier temps, nous avons caractérisé le lien entre PARP-1 et HMG2L1. L’interaction avec PARP-1 a été confirmée in-vivo et in vitro. Nous avons montré que HMG2L1 pouvait également interagir avec PARP-2. HMG2L1 est poly(ADP-ribosyl)ée par PARP-1 et PARP-2, de même qu’elle est capable d’interagir avec le poly(ADP-ribose). La construction de formes tronquées de HMG2L1 en fusion avec la GFP nous a permis de montrer que le domaine N-terminal – en amont du domaine HMG – est impliqué dans ces interactions. Ce domaine N-terminal est très électropositif et intrinsèquement désordonné ce qui lui confère de nombreuses potentialités d’interactions. L’expression des fusions GFP dans des cellules HeLa nous a permis de montrer la localisation nucléaire et nucléolaire de HMG2L1, comme c’est le cas pour PARP-1 et PARP- 2. En outre, HMG2L1 colocalise avec UBF (Upstream Binding Factor), le facteur de transcription de l’ARN polymérase I responsable de la transcription des ARN ribosomaux. La surexpression de GFP-hHMG2L1 entraîne un stress nucléolaire caractérisé par l’inhibition de la transcription des ADNr et la formation de coiffes nucléolaires. Nous avons également entrepris une recherche de partenaires de HMG2L1 par spectrométrie de masse. De nombreuses protéines nucléolaires, impliquées dans la biogenèse des ribosomes ou la maturation des ARNs ont été identifiées, suggérant un rôle de HMG2L1 dans ces processus. Nous avons montré que la protéine purifiée interagit avec l’ADN via son domaine HMG principalement, et qu’elle interagit avec l’ARN via son domaine N-terminal. Mais surtout, nous avons mis en évidence une activité ARN-chaperonne, qui peut être régulée par le poly(ADP-ribose). La localisation de HMG2L1, son réseau d’interaction ainsi que son activité chaperonne nous laissent à penser qu’elle pourrait être impliquée dans des processus de maturation des ARN, régulés par la poly(ADPribosyl)ation.

Poly(ADP-ribosyl)ation is a post-translational modification of proteins mediated by a family of enzymes called poly(ADP-ribose) polymerases. Among the best studied, PARP-1 and PARP-2 are both implicated into the transcription, organization and integrity of genome. We have initiated the characterization of a new PARP-1 partner previously identified in a yeast two-hybrid screen, and still poorly studied: HMG2L1…

Advisors/Committee Members: Schreiber, Valérie (thesis director).

Subjects/Keywords: Poly(ADP-ribosyl)ation; High-mobility group containing protein 2-like 1; Nucléole; Chaperonne à ARN; Protéine intrinsèquement désordonnée; Biogenèse des ribosomes; Poly(ADP-ribosyl)ation; High-mobility group containing protein 2-like 1; Nucleolus; RNA chaperon protein; Intrisically disordered protein; Biogenesis of ribosomes; 572.8

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Kalisch, T. (2013). Caractérisation fonctionnelle et biochimique d'un nouveau partenaire de la poly(ADP-ribose) polymérase I : high-mobility group protein containing 2-like 1 : Biochemical and functionnal characterization of a new partner of poly(ADP-ribose) polymerase I : high-mobility group containing protein 2-like 1. (Doctoral Dissertation). Université de Strasbourg. Retrieved from http://www.theses.fr/2013STRAJ068

Chicago Manual of Style (16^th Edition):

Kalisch, Thomas. “Caractérisation fonctionnelle et biochimique d'un nouveau partenaire de la poly(ADP-ribose) polymérase I : high-mobility group protein containing 2-like 1 : Biochemical and functionnal characterization of a new partner of poly(ADP-ribose) polymerase I : high-mobility group containing protein 2-like 1.” 2013. Doctoral Dissertation, Université de Strasbourg. Accessed January 24, 2021. http://www.theses.fr/2013STRAJ068.

MLA Handbook (7^th Edition):

Kalisch, Thomas. “Caractérisation fonctionnelle et biochimique d'un nouveau partenaire de la poly(ADP-ribose) polymérase I : high-mobility group protein containing 2-like 1 : Biochemical and functionnal characterization of a new partner of poly(ADP-ribose) polymerase I : high-mobility group containing protein 2-like 1.” 2013. Web. 24 Jan 2021.

Vancouver:

Kalisch T. Caractérisation fonctionnelle et biochimique d'un nouveau partenaire de la poly(ADP-ribose) polymérase I : high-mobility group protein containing 2-like 1 : Biochemical and functionnal characterization of a new partner of poly(ADP-ribose) polymerase I : high-mobility group containing protein 2-like 1. [Internet] [Doctoral dissertation]. Université de Strasbourg; 2013. [cited 2021 Jan 24]. Available from: http://www.theses.fr/2013STRAJ068.

Council of Science Editors:

Kalisch T. Caractérisation fonctionnelle et biochimique d'un nouveau partenaire de la poly(ADP-ribose) polymérase I : high-mobility group protein containing 2-like 1 : Biochemical and functionnal characterization of a new partner of poly(ADP-ribose) polymerase I : high-mobility group containing protein 2-like 1. [Doctoral Dissertation]. Université de Strasbourg; 2013. Available from: http://www.theses.fr/2013STRAJ068

Indian Institute of Science

15. Bharath, M M Srinivas. Towards The Understanding Of The Structural Biology Of Histone H1.

Degree: PhD, Faculty of Science, 2005, Indian Institute of Science

URL: http://etd.iisc.ac.in/handle/2005/167

► In the eukaryotic nucleus, an immense length of DNA is compactly packaged to generate an ordered three-dimensional hierarchical structure called chromatin (van Holde, 1988; Wolffe,… (more)

▼ In the eukaryotic nucleus, an immense length of DNA is compactly packaged to generate an ordered three-dimensional hierarchical structure called chromatin (van Holde, 1988; Wolffe, A.P, 1998). This organization forms a template for various DNA transaction processes like replication, transcription, recombination etc. The different stages of organization of the chromatin finally results in the 10,000-fold compaction observed in the metaphase chromosome. The problem of how the fibres of chromatin are folded has interested biologists and biochemists for decades. It has long been recognized that the Histones play a major part in this folding. However, the distinctly different roles of the Histones H2A, H2B, H3 and H4 on one hand and the lysine rich Histones such as Histone H1 and its cognates on the other, were not understood until after the discovery of the nucleosomes in the early 1970s. Some of the early insights into the structure of chromatin came through the digestion of nuclear chromatin with calcium-dependent endonucleases like micrococcal nuclease. A repeating kinetic intermediate of about 200 bp of DNA with Histones was obtained (Simpson, 1978). Based on repeating pattern of micrococcal nuclease digested chromatin and structural studies, Kornberg (1974) proposed that chromatin is composed of a flexible chain of repeating units of 100 A0 diameter. These units were termed as "nucleosomes" (Oudet et al, 1975). It then became clear that the Histones H2A, H2B, H3 and H4 were constituents of the nucleosome core particle whereas the lysine rich Histone H1 was somehow associated with the linker DNA between core particles. Hence, the formers are called core Histones and the latter as linker Histones. On further digestion of nucleosome, a nucleosome core was obtained in which wrapping of 146 bp of DNA about the Histone octamer to form the core particle provided the first level of folding. Electron microscopy and X-ray diffraction techniques suggested that this particle is a disk, 57 A0 thick and 110 A0 in diameter, and that the DNA is wound around the Histone core (Finch et al, 1977), But this cannot account for the many thousand-fold condensation of the DNA in the eukaryotic nucleus. The "string of beads" structure observed obviously could not satisfy the compaction requirement. It soon became evident that there exists some level of higher order folding of the chromatin fiber. In a classical paper, Finch and Klug (1976), showed that the extended nucleosomal filaments condense into irregular fibers of about 30 nm diameter in the presence of low concentrations of Mg 2+. Based on the data from earlier structural studies, these authors proposed a solenoid model in which nucleosomes were wrapped into a regular helix with a pitch of about 11nm. Later, it was observed that the formation of well defined fibers requires the presence of lysine rich Histones such as Histone H1. Advisors/Committee Members: Rao, M R S (advisor).

Subjects/Keywords: Cell Biology; Histones; Chromatins; Nucleosomes; High Mobility Group (HMG) Proteins; Nucleoproteins; Tata-Box Binding Protein (TBP)

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Bharath, M. M. S. (2005). Towards The Understanding Of The Structural Biology Of Histone H1. (Doctoral Dissertation). Indian Institute of Science. Retrieved from http://etd.iisc.ac.in/handle/2005/167

Chicago Manual of Style (16^th Edition):

Bharath, M M Srinivas. “Towards The Understanding Of The Structural Biology Of Histone H1.” 2005. Doctoral Dissertation, Indian Institute of Science. Accessed January 24, 2021. http://etd.iisc.ac.in/handle/2005/167.

MLA Handbook (7^th Edition):

Bharath, M M Srinivas. “Towards The Understanding Of The Structural Biology Of Histone H1.” 2005. Web. 24 Jan 2021.

Vancouver:

Bharath MMS. Towards The Understanding Of The Structural Biology Of Histone H1. [Internet] [Doctoral dissertation]. Indian Institute of Science; 2005. [cited 2021 Jan 24]. Available from: http://etd.iisc.ac.in/handle/2005/167.

Council of Science Editors:

Bharath MMS. Towards The Understanding Of The Structural Biology Of Histone H1. [Doctoral Dissertation]. Indian Institute of Science; 2005. Available from: http://etd.iisc.ac.in/handle/2005/167

Louisiana State University

16. Panday, Arvind. Linker Histone Functions of HMO1- Implications for DNA repair.

Degree: PhD, Life Sciences, 2016, Louisiana State University

URL: etd-10312016-222119 ; https://digitalcommons.lsu.edu/gradschool_dissertations/4217

► The DNA of eukaryotic cells does not exist in free linear strands; it is tightly packaged and wrapped around nuclear proteins in order to be… (more)

Subjects/Keywords: High mobility group protein; linker histone; DNA repair; chromatin

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Panday, A. (2016). Linker Histone Functions of HMO1- Implications for DNA repair. (Doctoral Dissertation). Louisiana State University. Retrieved from etd-10312016-222119 ; https://digitalcommons.lsu.edu/gradschool_dissertations/4217

Chicago Manual of Style (16^th Edition):

Panday, Arvind. “Linker Histone Functions of HMO1- Implications for DNA repair.” 2016. Doctoral Dissertation, Louisiana State University. Accessed January 24, 2021. etd-10312016-222119 ; https://digitalcommons.lsu.edu/gradschool_dissertations/4217.

MLA Handbook (7^th Edition):

Panday, Arvind. “Linker Histone Functions of HMO1- Implications for DNA repair.” 2016. Web. 24 Jan 2021.

Vancouver:

Panday A. Linker Histone Functions of HMO1- Implications for DNA repair. [Internet] [Doctoral dissertation]. Louisiana State University; 2016. [cited 2021 Jan 24]. Available from: etd-10312016-222119 ; https://digitalcommons.lsu.edu/gradschool_dissertations/4217.

Council of Science Editors:

Panday A. Linker Histone Functions of HMO1- Implications for DNA repair. [Doctoral Dissertation]. Louisiana State University; 2016. Available from: etd-10312016-222119 ; https://digitalcommons.lsu.edu/gradschool_dissertations/4217

Louisiana State University

17. Ray, Sreerupa. HMO2, a yeast HMGB protein that preferentially binds to DNA ends.

Degree: PhD, 2011, Louisiana State University

URL: etd-04132011-205535 ; https://digitalcommons.lsu.edu/gradschool_dissertations/415

► DNA damage is a common hazard that all cells have to combat. Saccharomyces cerevisiae HMO2 is a high mobility group protein (HMGB) that is a… (more)

Subjects/Keywords: dna strand invasion; dna binding; dna repair; high mobility group (hmgb) proteins

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Ray, S. (2011). HMO2, a yeast HMGB protein that preferentially binds to DNA ends. (Doctoral Dissertation). Louisiana State University. Retrieved from etd-04132011-205535 ; https://digitalcommons.lsu.edu/gradschool_dissertations/415

Chicago Manual of Style (16^th Edition):

Ray, Sreerupa. “HMO2, a yeast HMGB protein that preferentially binds to DNA ends.” 2011. Doctoral Dissertation, Louisiana State University. Accessed January 24, 2021. etd-04132011-205535 ; https://digitalcommons.lsu.edu/gradschool_dissertations/415.

MLA Handbook (7^th Edition):

Ray, Sreerupa. “HMO2, a yeast HMGB protein that preferentially binds to DNA ends.” 2011. Web. 24 Jan 2021.

Vancouver:

Ray S. HMO2, a yeast HMGB protein that preferentially binds to DNA ends. [Internet] [Doctoral dissertation]. Louisiana State University; 2011. [cited 2021 Jan 24]. Available from: etd-04132011-205535 ; https://digitalcommons.lsu.edu/gradschool_dissertations/415.

Council of Science Editors:

Ray S. HMO2, a yeast HMGB protein that preferentially binds to DNA ends. [Doctoral Dissertation]. Louisiana State University; 2011. Available from: etd-04132011-205535 ; https://digitalcommons.lsu.edu/gradschool_dissertations/415

18. Sigaut, Stéphanie. Activation microgliale : mécanismes et conséquences à long terme : Microglial activation : mechanisms and long term consequences.

Degree: Docteur es, Physiologie et biologie des organismes, populations, interactions. Neurosciences, 2017, Sorbonne Paris Cité

URL: http://www.theses.fr/2017USPCC198

►

La neuro-inflammation induite par l'inflammation systémique ou générée en réponse à une lésion cérébrale aiguë a des conséquences cliniques néfastes : elle est mise en… (more)

▼

La neuro-inflammation induite par l'inflammation systémique ou générée en réponse à une lésion cérébrale aiguë a des conséquences cliniques néfastes : elle est mise en cause dans l'aggravation des lésions cérébrales aiguës chez l'homme, aussi bien chez l'adulte que chez l'enfant. La microglie est l'effecteur cérébral principal de cette réponse inflammatoire, et peut présenter selon les situations un profil neurotoxique ou, au contraire, anti-inflammatoire et régulateur. La compréhension des mécanismes d'activation microgliale et de leurs conséquences est capitale pour une meilleure prise en charge des malades. La première partie de ce travail de thèse s'intéresse aux conséquences de l'inflammation néonatale associée à la prématurité sur la réponse microgliale à l'âge adulte, face à de nouvelles agressions cérébrales que sont l'inflammation systémique et les lésions cérébrales aiguës. Dans un modèle murin d'inflammation néonatale, nous avons mis en évidence d'importantes modifications du transcriptome microglial une fois ces souris adultes. De plus, un stimulus inflammatoire à l'âge adulte modifie le profil d'activation microgliale, le pic des marqueurs pro-inflammatoires et immuno-régulateurs survenant plus précocement et intensément, démontrant l'existence d'une mémoire du système immunitaire inné cérébral. Ces modifications dans le profil d'activation microgliale s'accompagnent dans un modèle de lésion cérébrale excitotoxique d'une majoration de la taille des lésions de la substance blanche. Un traitement par mélatonine des souriceaux prévient cette aggravation. La deuxième partie de ce travail a consisté à caractériser in vitro le profil d'activation microgliale en réponse à une stimulation par HMGB1, une alarmine relarguée lors de la mort cellulaire et donc présente en cas de lésion cérébrale aiguë mais aussi de lésions extra-crâniennes associées. Nous avons montré que le profil d'activation microgliale dépend du type d'HMGB1 utilisé. Les microglies exposées à la forme recombinante de chez Sigma présentent un profil transcriptomique proinflammatoire mais une baisse des taux de cytokines sécrétées dans le milieu. Ces résultats mettent en évidence l'importance de l'inflammation et de l'activation microgliale dans le pronostic des lésions cérébrales et offrent la possibilité de mettre en place des stratégies neuroprotectrices innovantes

Neuroinflammation induced by systemic inflammation or generated in response to acute brain injury has adverse clinical consequences: it is implicated in exacerbation of acute brain injury in humans, for adults as well as for children. Microglia is the main effector of this cerebral inflammatory response, and may present, depending on the situation, a neurotoxic or - on the opposite - anti-inflammatory and regulating profile. To decipher the mechanisms of microglial activation and their consequences is essential for better management of patients.The first part of this thesis focuses on the consequences of neonatal inflammation associated with prematurity on the microglial response…

Advisors/Committee Members: Gressens, Pierre (thesis director).

Subjects/Keywords: HMGB1; Neuro-inflammation; Prematurity; DAMP; HMGB1

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Sigaut, S. (2017). Activation microgliale : mécanismes et conséquences à long terme : Microglial activation : mechanisms and long term consequences. (Doctoral Dissertation). Sorbonne Paris Cité. Retrieved from http://www.theses.fr/2017USPCC198

Chicago Manual of Style (16^th Edition):

Sigaut, Stéphanie. “Activation microgliale : mécanismes et conséquences à long terme : Microglial activation : mechanisms and long term consequences.” 2017. Doctoral Dissertation, Sorbonne Paris Cité. Accessed January 24, 2021. http://www.theses.fr/2017USPCC198.

MLA Handbook (7^th Edition):

Sigaut, Stéphanie. “Activation microgliale : mécanismes et conséquences à long terme : Microglial activation : mechanisms and long term consequences.” 2017. Web. 24 Jan 2021.

Vancouver:

Sigaut S. Activation microgliale : mécanismes et conséquences à long terme : Microglial activation : mechanisms and long term consequences. [Internet] [Doctoral dissertation]. Sorbonne Paris Cité; 2017. [cited 2021 Jan 24]. Available from: http://www.theses.fr/2017USPCC198.

Council of Science Editors:

Sigaut S. Activation microgliale : mécanismes et conséquences à long terme : Microglial activation : mechanisms and long term consequences. [Doctoral Dissertation]. Sorbonne Paris Cité; 2017. Available from: http://www.theses.fr/2017USPCC198

Victoria University of Wellington

19. Li, Qiannan. Use it or Lose it!.

Degree: 2017, Victoria University of Wellington

URL: http://hdl.handle.net/10063/6654

► In the foreseeable future, the elderly will make up a significant proportion of New Zealand’s population. The relationship between ageing and disability means the disabled… (more)

Subjects/Keywords: Ageing group; Disabled elderly; Rehabilitation; Mobility

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Li, Q. (2017). Use it or Lose it!. (Masters Thesis). Victoria University of Wellington. Retrieved from http://hdl.handle.net/10063/6654

Chicago Manual of Style (16^th Edition):

Li, Qiannan. “Use it or Lose it!.” 2017. Masters Thesis, Victoria University of Wellington. Accessed January 24, 2021. http://hdl.handle.net/10063/6654.

MLA Handbook (7^th Edition):

Li, Qiannan. “Use it or Lose it!.” 2017. Web. 24 Jan 2021.

Vancouver:

Li Q. Use it or Lose it!. [Internet] [Masters thesis]. Victoria University of Wellington; 2017. [cited 2021 Jan 24]. Available from: http://hdl.handle.net/10063/6654.

Council of Science Editors:

Li Q. Use it or Lose it!. [Masters Thesis]. Victoria University of Wellington; 2017. Available from: http://hdl.handle.net/10063/6654

University of Michigan

20. Burns, Veronica Elizabeth. Structural Basis and Functional Consequences of Alternative ATF2-Jun Heterodimer Orientations at the Interferon-Beta Enhancer.

Degree: PhD, Biological Chemistry, 2011, University of Michigan

URL: http://hdl.handle.net/2027.42/89855

► The selective activation of genes is essential for diverse biological processes such as growth, development, and responses to environmental cues. Unlike lower organisms that often… (more)

▼ The selective activation of genes is essential for diverse biological processes such as growth, development, and responses to environmental cues. Unlike lower organisms that often use individual proteins to control gene activation, transcription regulation in higher organisms generally requires cooperation among multiple proteins. Cooperation can be achieved via interactions between DNA-binding proteins that bind to adjoining DNA sequences. Such interactions can stabilize DNA binding by these proteins. Many eukaryotic transcription factors form heterodimers that can bind to DNA in two opposite orientations. Because of the asymmetry of such heterodimers, cooperative DNA binding has been predicted, and in some cases observed, to require a specific orientation of heterodimer binding. Interferon regulatory factor 3 (IRF3) and a heterodimer containing activating transcription factor 2 and c-Jun (ATF2-Jun) bind cooperatively to the human interferon-beta enhancer, and opposite orientations of ATF2-Jun binding have been observed using different experimental approaches. High mobility group protein I (HMGI) binds to sequences overlapping the ATF2-Jun-IRF3 site within the interferon-beta enhancer and facilitates DNA-binding and synergistic transcriptional activation by components of the enhancer complex, yet its effects on ATF2-Jun-IRF3 complex formation have not been investigated. This thesis presents the identification of the structural determinants of ATF2-Jun heterodimer orientation at the interferon-beta enhancer in vitro as well as functional characterization in cells. Using gel-based fluorescence resonance energy transfer analysis, I found that ATF2-Jun binds to the interferon-beta enhancer in both orientations alone and in association with IRF3 and HMGI. Two symmetry-related sets of amino acid residues in ATF2 and Jun facilitated the opposite orientations of heterodimer interactions with IRF3 at the interferon-beta enhancer. Expression of ATF2 and Jun variants that bound the interferon-beta enhancer in opposite orientations together with IRF3 produced distinct levels of interferon-beta transcription in Sendai-virus infected Hela cells. Expression of these proteins resulted in different relative levels of transcription of different genes regulated by ATF2 and Jun. Collectively, this work illustrates a novel mode of cooperative DNA-binding by transcription factors and suggests that alternative nucleoprotein arrangements can influence transcriptional activity through distinct mechanisms at different genes. Advisors/Committee Members: Kerppola, Tom K W (committee member), Engelke, David R. (committee member), Gafni, Ari (committee member), Trievel, Raymond C. (committee member), Walter, Nils G. (committee member).

Subjects/Keywords: Activating Transcription Factor 2; C-Jun; Cooperative DNA-Binding; Fluorescence Resonance Energy Transfer; High Mobility Group I; Interferon Regulatory Factor 3; Biological Chemistry; Science

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Burns, V. E. (2011). Structural Basis and Functional Consequences of Alternative ATF2-Jun Heterodimer Orientations at the Interferon-Beta Enhancer. (Doctoral Dissertation). University of Michigan. Retrieved from http://hdl.handle.net/2027.42/89855

Chicago Manual of Style (16^th Edition):

Burns, Veronica Elizabeth. “Structural Basis and Functional Consequences of Alternative ATF2-Jun Heterodimer Orientations at the Interferon-Beta Enhancer.” 2011. Doctoral Dissertation, University of Michigan. Accessed January 24, 2021. http://hdl.handle.net/2027.42/89855.

MLA Handbook (7^th Edition):

Burns, Veronica Elizabeth. “Structural Basis and Functional Consequences of Alternative ATF2-Jun Heterodimer Orientations at the Interferon-Beta Enhancer.” 2011. Web. 24 Jan 2021.

Vancouver:

Burns VE. Structural Basis and Functional Consequences of Alternative ATF2-Jun Heterodimer Orientations at the Interferon-Beta Enhancer. [Internet] [Doctoral dissertation]. University of Michigan; 2011. [cited 2021 Jan 24]. Available from: http://hdl.handle.net/2027.42/89855.

Council of Science Editors:

Burns VE. Structural Basis and Functional Consequences of Alternative ATF2-Jun Heterodimer Orientations at the Interferon-Beta Enhancer. [Doctoral Dissertation]. University of Michigan; 2011. Available from: http://hdl.handle.net/2027.42/89855

Miami University

21. Hassan, Faizule. Adenovirus Mediated Delivery of Decoy Hyper Binding Sites for Sequestration of an Oncogenic Transcription Factor HMGA as a Potential Novel Cancer Therapy and Antibacterial Activity of Local Mushrooms.

Degree: PhD, Cell, Molecular and Structural Biology (CMSB), 2017, Miami University

URL: http://rave.ohiolink.edu/etdc/view?acc_num=miami1511449587326648

► The first section of this dissertation describes the development of strategies for the treatment of pancreatic cancer using a novel synthetic DNA sequence that functions… (more)

▼ The first section of this dissertation describes the development of strategies for the treatment of pancreatic cancer using a novel synthetic DNA sequence that functions as decoy binding site for an oncogenic protein called high mobility group A (HMGA) and adenovirus mediated gene therapy. The second part of this dissertation describes a survey study for evaluating the antibacterial activity of mushroom samples collected from local areas. The Chapter 1 provides background information about the HMGA and its role in tumor development and cancer progression. The Chapter 1 also provides background information about the adenovirus and its use in cancer treatment. In addition, Chapter 1 discusses about the medicinal use and antibacterial potential of mushrooms. In Chapter 2, we have devised a strategy of using engineered replication-defective adenovirus (Ad) to deliver decoy hyper binding sites for HMGA to the nucleus of cancer cells with the goal of sequestering excess HMGA at the decoy hyper binding sites due to binding competition. Sequestration of excess HMGA at the decoy binding sites is intended to reduce HMGA binding at the naturally occurring genomic HMGA binding sites, which should result in normalized gene expression and restored sensitivity to chemotherapy. Infection of five different pancreatic and liver cancer cell lines with the Ad containing the HMGA decoy hyper binding sites resulted in significant reduction in cell viability and increased sensitivity to chemotherapy. The Chapter 3 discusses toxicity and biodistribution following injection of the Ad containing the HMGA decoy hyper binding sites into mice liver or pancreas. This study provides essential preclinical information regarding toxicity and biodistribution needed to determine the potential of our engineered virus for future treatment of cancer in humans. The Cahpter 4 demonstrated a strategy to develop a conditionally replicating Ad virus which will selectively replicate in cancer cells while being unable to replicate in normal cells. We have shown that the deletion of two genes, E1ACR2 and E1B19K, increased cancer selective replication of the Ad and decrease chemotherapy resistance of pancreatic cacner cells. In Chapter 5, we have described a survey study where we showed antibacterial activity in 25 mushroom samples out of the 75 samples tested. Finally the Chapter 6 summarizes the present research and shows future direction. Advisors/Committee Members: Kennedy, Michael (Advisor), Dabney-Smith, Carole (Committee Chair).

Subjects/Keywords: Biochemistry; Molecular Biology; High Mobility Group A; HMGA; Adenovirus; Replication-competent adenovirus; Replication-defective adenovirus; Cancer; Chemotherapy; Gene delivery; Mushroom; Antibiotic resistance

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Hassan, F. (2017). Adenovirus Mediated Delivery of Decoy Hyper Binding Sites for Sequestration of an Oncogenic Transcription Factor HMGA as a Potential Novel Cancer Therapy and Antibacterial Activity of Local Mushrooms. (Doctoral Dissertation). Miami University. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=miami1511449587326648

Chicago Manual of Style (16^th Edition):

Hassan, Faizule. “Adenovirus Mediated Delivery of Decoy Hyper Binding Sites for Sequestration of an Oncogenic Transcription Factor HMGA as a Potential Novel Cancer Therapy and Antibacterial Activity of Local Mushrooms.” 2017. Doctoral Dissertation, Miami University. Accessed January 24, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=miami1511449587326648.

MLA Handbook (7^th Edition):

Hassan, Faizule. “Adenovirus Mediated Delivery of Decoy Hyper Binding Sites for Sequestration of an Oncogenic Transcription Factor HMGA as a Potential Novel Cancer Therapy and Antibacterial Activity of Local Mushrooms.” 2017. Web. 24 Jan 2021.

Vancouver:

Hassan F. Adenovirus Mediated Delivery of Decoy Hyper Binding Sites for Sequestration of an Oncogenic Transcription Factor HMGA as a Potential Novel Cancer Therapy and Antibacterial Activity of Local Mushrooms. [Internet] [Doctoral dissertation]. Miami University; 2017. [cited 2021 Jan 24]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=miami1511449587326648.

Council of Science Editors:

Hassan F. Adenovirus Mediated Delivery of Decoy Hyper Binding Sites for Sequestration of an Oncogenic Transcription Factor HMGA as a Potential Novel Cancer Therapy and Antibacterial Activity of Local Mushrooms. [Doctoral Dissertation]. Miami University; 2017. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=miami1511449587326648

Miami University

22. Schmahl, Michelle Jordan. Metabolic Profiling of Urine, Fecal, and Serum Samples and Pancreatic Tumors and Evaluation of HMGA1 Expression Levels in Pancreatic Intraepithelial Neoplasia Cells in the Ptf1a-Cre; LSL-KrasG12D Transgenic Mouse Model of Pancreatic Cancer.

Degree: PhD, Chemistry, 2018, Miami University

URL: http://rave.ohiolink.edu/etdc/view?acc_num=miami1523977530802748

► Pancreatic cancer is the third leading cause of cancer related deaths. Individuals inflicted with this cancer are typically asymptomatic until advanced stages are reached. Surgical… (more)

▼ Pancreatic cancer is the third leading cause of cancer related deaths. Individuals inflicted with this cancer are typically asymptomatic until advanced stages are reached. Surgical procedures provide the greatest chance of survival; nevertheless, pancreatic cancer is rarely detected in early stages where surgery would be effective. This is primarily due to the lack of dependable tests for early detection and diagnosis. Current diagnostic methods are extremely invasive or are deemed inadequate by general consensus, and population screening for pancreatic cancer with these methods is not feasible. Urine and fecal excrements have been shown to encompass potentially useful biomarkers in pancreatic cancer. In this dissertation, potential early biomarkers in serum, urine, and blood were identified through the use of the mouse model Ptf1aCre; LSL-KrasG12D of pancreatic cancer and nuclear magnetic resonance spectroscopy (NMR). Additionally, a histology atlas of pancreatic tissue was produced to aid in the evaluation of the precancerous stages, referred to as pancreatic intraepithelial neoplasia (PanIN). Due to the existence of multiple classification systems being in use, discrepancies among the field exist. The generated atlas will promote discussion and clarification of the PanIN stages. In order to acquire images, removal of the pancreas had to be performed. Due to the lack of peer-reviewed and high quality videos and instructions available, a manuscript accompanied by a video were produced to show the proper procedures to successfully remove the pancreas by dissection from a mouse. Also, high-mobility growth A1 protein (HMGA1), that has been linked to tumor progression in many cancers, had not been examined with the Ptf1aCre; LSL-KrasG12D mouse model until now. Elevated levels of HMGA1 have been shown to be present in as young as 5-months in the PanIN mice and in as old as 15-months when compared to normal un-transitioned pancreatic tissue. This dissertation encompasses many tools, platforms, and analyses assisting in the progression of early diagnostic pancreatic cancer research. Advisors/Committee Members: Kennedy, Michael (Advisor), Makaroff, Christopher (Committee Chair).

Subjects/Keywords: Chemistry; Biochemistry; pancreas, pancreatic cancer, pancreatic ductal adenocarcinoma, adenocarcinoma, pancreatic intraepithelial neoplasia, PanIN, pancreas dissection, mouse pancreas dissection, mouse, HMGA1, high-mobility group A protein, atlas, histology

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Schmahl, M. J. (2018). Metabolic Profiling of Urine, Fecal, and Serum Samples and Pancreatic Tumors and Evaluation of HMGA1 Expression Levels in Pancreatic Intraepithelial Neoplasia Cells in the Ptf1a-Cre; LSL-KrasG12D Transgenic Mouse Model of Pancreatic Cancer. (Doctoral Dissertation). Miami University. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=miami1523977530802748

Chicago Manual of Style (16^th Edition):

Schmahl, Michelle Jordan. “Metabolic Profiling of Urine, Fecal, and Serum Samples and Pancreatic Tumors and Evaluation of HMGA1 Expression Levels in Pancreatic Intraepithelial Neoplasia Cells in the Ptf1a-Cre; LSL-KrasG12D Transgenic Mouse Model of Pancreatic Cancer.” 2018. Doctoral Dissertation, Miami University. Accessed January 24, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=miami1523977530802748.

MLA Handbook (7^th Edition):

Schmahl, Michelle Jordan. “Metabolic Profiling of Urine, Fecal, and Serum Samples and Pancreatic Tumors and Evaluation of HMGA1 Expression Levels in Pancreatic Intraepithelial Neoplasia Cells in the Ptf1a-Cre; LSL-KrasG12D Transgenic Mouse Model of Pancreatic Cancer.” 2018. Web. 24 Jan 2021.

Vancouver:

Schmahl MJ. Metabolic Profiling of Urine, Fecal, and Serum Samples and Pancreatic Tumors and Evaluation of HMGA1 Expression Levels in Pancreatic Intraepithelial Neoplasia Cells in the Ptf1a-Cre; LSL-KrasG12D Transgenic Mouse Model of Pancreatic Cancer. [Internet] [Doctoral dissertation]. Miami University; 2018. [cited 2021 Jan 24]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=miami1523977530802748.

Council of Science Editors:

Schmahl MJ. Metabolic Profiling of Urine, Fecal, and Serum Samples and Pancreatic Tumors and Evaluation of HMGA1 Expression Levels in Pancreatic Intraepithelial Neoplasia Cells in the Ptf1a-Cre; LSL-KrasG12D Transgenic Mouse Model of Pancreatic Cancer. [Doctoral Dissertation]. Miami University; 2018. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=miami1523977530802748

Bowling Green State University

23. Longo-Capobianco, Samuel John. Black box [1].

Degree: MM, Music Composition, 2020, Bowling Green State University

URL: http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1585583128274337

► black box [1] is an approximately seven-minute, single-movement work for full orchestra. This piece is not programmatic; rather, the piece’s structure is determined by its… (more)

▼ black box [1] is an approximately seven-minute, single-movement work for full orchestra. This piece is not programmatic; rather, the piece’s structure is determined by its content.black box [1] is cast in two large sections. In the first section, instruments are separated into three broad registral areas (high, mid, and low). Each group plays a discrete thematic idea. The piece begins with each theme stated in turn and they develop as the section progresses. As the themes develop, they begin interrupting one another. These interruptions become more frequent as the section progresses, and at the section’s climax, all three themes play simultaneously.A percussion solo immediately follows the climax and leads to the piece’s second section. Similar to the first section, the second section features three different melodic ideas. After these are introduced, they develop into three different phrases using pitches from each theme put into randomized orders. Each phrase differs in length so that they do not coincide with each other in the same way for each iteration. These phrases repeat until the piece’s end.The piece’s first section is cast in Lydian mode and the harmony modulates twice. The piece’s second section is cast in a minor key. Each melodic theme in the second section utilizes a different subset from a minor scale and the key also modulates two times in this section. The final part of the second section (with repeated phrases) sounds pandiatonic because the limited pitch material and the randomized combination of pitches do not create a sense of hierarchy or utilize functional harmony.Rhythm plays an important role in black box [1]. The piece is mostly notated in common time so it can be easily read, with other meters used occasionally in order to begin new phrases on a downbeat. The first section has an upbeat tempo and features frequent rhythmic syncopation. The second section unfolds at a slower tempo (a 33.3% decrease from the first section). This section feels much more rhythmically “floating” than the preceding section. Advisors/Committee Members: Lillios, Elainie (Advisor).

Subjects/Keywords: Music; music composition; orchestra; Samuel Longo-Capobianco; black box 1

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Longo-Capobianco, S. J. (2020). Black box [1]. (Masters Thesis). Bowling Green State University. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1585583128274337

Chicago Manual of Style (16^th Edition):

Longo-Capobianco, Samuel John. “Black box [1].” 2020. Masters Thesis, Bowling Green State University. Accessed January 24, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1585583128274337.

MLA Handbook (7^th Edition):

Longo-Capobianco, Samuel John. “Black box [1].” 2020. Web. 24 Jan 2021.

Vancouver:

Longo-Capobianco SJ. Black box [1]. [Internet] [Masters thesis]. Bowling Green State University; 2020. [cited 2021 Jan 24]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1585583128274337.

Council of Science Editors:

Longo-Capobianco SJ. Black box [1]. [Masters Thesis]. Bowling Green State University; 2020. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1585583128274337

KTH

24. Svahn, Morgan. Kulturkuben.

Degree: Architecture, 2015, KTH

URL: http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-168561

►

En kulturskola är inte ett skyltfönster för barnens talang utan en kreativ verkstad för att utvecklas. Detta har jag tagit fasta på och har… (more)

▼

En kulturskola är inte ett skyltfönster för barnens talang utan en kreativ verkstad för att utvecklas. Detta har jag tagit fasta på och har en idé om en kulturskola där större delen av skolan är vikt till barnens trygghet. De vuxna har sin plats och resten av byggnaden är barnens. Här ska blyga kunna öva i trygghet och de som vill spela ut hela sin repertoar har möjlighet till det. Skolan ska också kunna vara en plats att hänga på någon timme innan sin lektion. Gestaltningsmässigt har skolan här ett öppet foajéplan som är semioffentlig. Caféet är öppet för allmänheten och kan användas för utställningar, föreläsningar och liknande. Men denna yta är också den som är de vuxnas. Kommer du med ditt barn så är det här du får vänta medan barnet springer in och gör sitt. Resten av foajéplanet är en flexibel yta som egentligen kan programmeras lite hur som helst. Uppåt i huset finns en yta för barn, som ett väntrum, där de kan hänga innan sin lektion. Uppåt finns också lektionssalar. Blandad verksamhet för att blanda barnen. Den nedre delen av huset är nästan som ett helt annat hus. Här finns verksamhetslokaler samt flertalet av de servicefunktioner som måste finnas. Ytan att vistas på är här begränsad då det inte är tänkt att man ska uppehålla sig här mellan lektionerna. Som en bärande idé har jag fört med mig forskning som visar på hur man kan bygga bort mobbning. Huset har inga långa dolda korridorer och överallt kan lärare överse, utan att bevaka, alla utrymmen där barnen befinner sig. Med hörsel och syn kopplas hela huset samman genom principen att visuell och audiell kommunikation är trygghetens kärna.

A Culture school should not be a kids talent show room. It should be a creative shop for their own development. This is the starting point of my project. I have an idea of a culture school where the bigger part is for the children and only the children. A place to be safe. The shy kids should be able to practice in a safe environment and the more outspoken kids will have the opportunity to perform. This, normally a place you just spend a lesson at, should be a place to hang around after school. The entrance floor is a semi public floor with an café open for the public and with an area to have flexible purposes, maybe a show room one day and an open lecture the next. This area is the only area for the grown ups. When you pass through into the building you are in the world for the kids. The flexible entrance floor is accompanied with a ”half floor” entirely voided for the kids to hang at. Another floor up and two floors down you’ll find the rooms for different activities. The entire house is devoted to minimize bullying. No long corridors, a constant ability for teachers to watch the kids without being monitors and throughout the house you can hear, and almost see, everything.

Subjects/Keywords: Culture school; black box; anti bullying; Älvsjö; Mässhallen 1; Kulturskola; Kulturskolan; Stockholm; mobbning; anti-mobbning; betong; glas; aluminium; lektionssalar; black box

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APA (6^th Edition):

Svahn, M. (2015). Kulturkuben. (Thesis). KTH. Retrieved from http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-168561

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Svahn, Morgan. “Kulturkuben.” 2015. Thesis, KTH. Accessed January 24, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-168561.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Svahn, Morgan. “Kulturkuben.” 2015. Web. 24 Jan 2021.

Vancouver:

Svahn M. Kulturkuben. [Internet] [Thesis]. KTH; 2015. [cited 2021 Jan 24]. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-168561.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Svahn M. Kulturkuben. [Thesis]. KTH; 2015. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-168561

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

NSYSU

25. Chen, Yen-Liang. The Study of High-Mobility AlxGa1-xN/GaN Heterostructures Grown by Plasma-assisted Molecular Beam Epitaxy.

Degree: PhD, Physics, 2010, NSYSU

URL: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0805110-191827

► The quality of GaN template layer plays a very important role in high electron mobility transistors. We proposed a special method in the growth of… (more)

▼ The quality of GaN template layer plays a very important role in high electron mobility transistors. We proposed a special method in the growth of molecular beam epitaxy to deal with the dilemma between structure and the morphology of GaN. In our study, we used a nitrogen-rich GaN growth condition to deposit the initial varied layer. After that, we changed the N/Ga ratio stepwise to the growth condition of gallium-rich GaN and grew the epitaxy layer right away. In X-ray diffraction analysis, the full width at half-maximum (FWHM) value of rocking curves of GaN(002) was improved relatively to gallium-rich sample from 531.69 arcsecond to 59.43 arcsecond. In atomic force microscopy (AFM) analysis, the root mean square (rms) roughness of sample surface was improved relatively to nitrogen-rich sample from 18.28 nm to 1.62 nm over 5 Î¼m Ã 5 Î¼m area. The Raman scattering shows there is a slightly tilted plane in gradient layer and the gradient layer can also slash the strain force which is caused from Ga-rich GaN epitaxy layer and AlN buffer layer. A series high mobility AlxGa1-xN/GaN heterostructures samples were grown on MOVPE-grown GaN templates substrate by molecular beam epitaxy with different Al concentrations (x = 0.017~0.355). The quality checked by XRD and AFM indicated that the excellent properties agreed with the GaN-template. The highest mobility in this series samples at 8 K is 19593 cm2/Vs with carrier concentration 3.13 Ã 1012 cm-2 and Al concentration x = 0.017. In our experiments, the carrier density decreases as Al concentration reduces. In the illuminated Hall measurement, there are only few electrons increased following blue LED illumination. It shows that there are only few deep level defects existing near the heterointerface. From temperature-depended Shubnikov-de Haas (SdH) oscillations, the electron effective mass m* in 2DEG are evaluated as 0.213 mo and for x = 0.207 0.227 moand 0.136 respectively. The high mobility AlxGa1-xN/GaN was fabricated to a series of wires by focused ion beam (FIB) equipment, and the width of the active channel is ranged from 900 nm to 50 nm (900 nm, 500 nm, 300 nm, 200 nm, 100 nm, 80 nm and 50 nm) with the channel orientation in [11 0] direction. The largest spin-splitting energy in the series of wires is 2.14 meV. Due to larger spin-splitting energy and quasi-ballistic transportation, the 200 nm wire is the best candidate to be the channel of the quantum-ring interferometer in our case. Advisors/Committee Members: Kuang-Yeu Hsieh (chair), Wan-Sun Tse (chair), Ikai Lo (committee member), Ming-Kuei Lee (chair), Hsing-Lu Huang (chair).

Subjects/Keywords: nano wire; high mobility; MBE; GaN; AlGaN

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Chen, Y. (2010). The Study of High-Mobility AlxGa1-xN/GaN Heterostructures Grown by Plasma-assisted Molecular Beam Epitaxy. (Doctoral Dissertation). NSYSU. Retrieved from http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0805110-191827

Chicago Manual of Style (16^th Edition):

Chen, Yen-Liang. “The Study of High-Mobility AlxGa1-xN/GaN Heterostructures Grown by Plasma-assisted Molecular Beam Epitaxy.” 2010. Doctoral Dissertation, NSYSU. Accessed January 24, 2021. http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0805110-191827.

MLA Handbook (7^th Edition):

Chen, Yen-Liang. “The Study of High-Mobility AlxGa1-xN/GaN Heterostructures Grown by Plasma-assisted Molecular Beam Epitaxy.” 2010. Web. 24 Jan 2021.

Vancouver:

Chen Y. The Study of High-Mobility AlxGa1-xN/GaN Heterostructures Grown by Plasma-assisted Molecular Beam Epitaxy. [Internet] [Doctoral dissertation]. NSYSU; 2010. [cited 2021 Jan 24]. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0805110-191827.

Council of Science Editors:

Chen Y. The Study of High-Mobility AlxGa1-xN/GaN Heterostructures Grown by Plasma-assisted Molecular Beam Epitaxy. [Doctoral Dissertation]. NSYSU; 2010. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0805110-191827

NSYSU

26. Hsu, Wen-Ti. Study of pancreatic cancer antigen detection using AlGaN/GaN high electron mobility transistor biosensor with different aluminum content.

Degree: Master, Physics, 2013, NSYSU

URL: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0711113-222628

► Compared to classical lab instrumentation, the biosensors are being increasingly exploited as promising diagnostic devices for their advantages, such as label-free, ultrasensitive, highly selective, high… (more)

▼ Compared to classical lab instrumentation, the biosensors are being increasingly exploited as promising diagnostic devices for their advantages, such as label-free, ultrasensitive, highly selective, high accuracy, fast and real-time detection. Fabricating biosensor chip has great benefits for gene-detection, protein-detection, medical diagnosis and development new medicine. The goal of this research work is to develop nitrideâbased high electron mobility transistor (N-HEMT) biosensor for the detection pancreatic cancer marker carbohydrate 19-9 (CA19-9) antigen for early detection of pancreatic cancer. ããN-HEMT biosensor was fabricated through microelectronic semiconductor process technology by growing AlGaN/GaN film using molecular beam epitaxy (MBE). The surface of N-HEMT biosensor was functionalized with modify pancreatic cancer marker CA 19-9 antibody for the detection of pancreatic cancer marker CA19-9 antigen molecule. The proposed research was focused on two important objectives. At first, N- N-HEMT biosensor was subjected to rapid thermal annealing (RTA) temperatures to optimize the device performance by enhancing metal ohmic contact. Secondly, the aluminum content N-HEMT biosensor was changed to investigate the effect on the performance of the device during biosensing. ããIt was observed that The RTA at 700â resulting in better performance which is evident from the Isd-Vsd measurement and during detection of CA19-9 antigen detection with a minimum concentration of 150 U/mL. When the influence aluminum content of was investigated, it was observed that N-HEMT biosensor with 29% aluminum content has shown a better performance compared with N-HEMT biosensor with 49% aluminum content during CA19-9 antigen detection with a minimum concentration 150 U/mL. ããFinally, N-HEMT biosensor was successfully fabricated and implemented for early pancreatic cancer detection, which provided important information for the future development of high sensitivity N-HEMT biosensor for a variety of biological sensing experiments. Advisors/Committee Members: Kuang-hung Cheng (chair), Li-Wei Tu (committee member), Wei-Feng Tsai (chair), Hay-Yan Jack Wang (chair), Shuchen Hsieh (chair).

Subjects/Keywords: Nitride; biosensor; high electron mobility; pancreatic cancer

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Hsu, W. (2013). Study of pancreatic cancer antigen detection using AlGaN/GaN high electron mobility transistor biosensor with different aluminum content. (Thesis). NSYSU. Retrieved from http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0711113-222628

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Hsu, Wen-Ti. “Study of pancreatic cancer antigen detection using AlGaN/GaN high electron mobility transistor biosensor with different aluminum content.” 2013. Thesis, NSYSU. Accessed January 24, 2021. http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0711113-222628.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Hsu, Wen-Ti. “Study of pancreatic cancer antigen detection using AlGaN/GaN high electron mobility transistor biosensor with different aluminum content.” 2013. Web. 24 Jan 2021.

Vancouver:

Hsu W. Study of pancreatic cancer antigen detection using AlGaN/GaN high electron mobility transistor biosensor with different aluminum content. [Internet] [Thesis]. NSYSU; 2013. [cited 2021 Jan 24]. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0711113-222628.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Hsu W. Study of pancreatic cancer antigen detection using AlGaN/GaN high electron mobility transistor biosensor with different aluminum content. [Thesis]. NSYSU; 2013. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0711113-222628

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Virginia Tech

27. Vandyke, Alex J. Development of a High-Speed Rail Model to Study Current and Future High-Speed Rail Corridors in the United States.

Degree: MS, Civil Engineering, 2011, Virginia Tech

URL: http://hdl.handle.net/10919/76794

► A model that can be used to analyze both current and future high-speed rail corridors is presented in this work. This model has been integrated… (more)

▼ A model that can be used to analyze both current and future high-speed rail corridors is presented in this work. This model has been integrated into the Transportation Systems Analysis Model (TSAM). The TSAM is a model used to predict travel demand between any two locations in the United States, at the county level. The purpose of this work is to develop tools that will create the necessary input data for TSAM, and to update the model to incorporate passenger rail as a viable mode of transportation. This work develops a train dynamics model that can be used to calculate the travel time and energy consumption of multiple high-speed train types while traveling between stations. The work also explores multiple options to determine the best method of improving the calibration and implementation of the model in TSAM. For the mode choice model, a standard C logit model is used to calibrate the mode choice model. The utility equation for the logit model uses the decision variables of travel time and travel cost for each mode. A modified utility equation is explored; the travel time is broken into an in-vehicle and out-of-vehicle time in an attempt to improve the model, however the test determines that there is no benefit to the modification. In addition to the C-logit model, a Box-Cox transformation is applied to both variables in the utility equation. This transformation removes some of the linear assumptions of the logit model and thus improves the performance of the model. The calibration results are implemented in TSAM, where both existing and projected high-speed train corridors are modeled. The projected corridors use the planned alignment for modeling. The TSAM model is executed for the cases of existing train network and projected corridors. The model results show the sensitivity of travel demand by modeling the future corridors with varying travel speeds and travel costs. The TSAM model shows the mode shift that occurs because of the introduction of high-speed rail. Advisors/Committee Members: Trani, Antoino A. (committeechair), Flintsch, Gerardo W. (committee member), Abbas, Montasir M. (committee member).

Subjects/Keywords: Logit Model; Box Cox; High-Speed Train; American Travel Survey; Amtrak; High-Speed Rail

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Vandyke, A. J. (2011). Development of a High-Speed Rail Model to Study Current and Future High-Speed Rail Corridors in the United States. (Masters Thesis). Virginia Tech. Retrieved from http://hdl.handle.net/10919/76794

Chicago Manual of Style (16^th Edition):

Vandyke, Alex J. “Development of a High-Speed Rail Model to Study Current and Future High-Speed Rail Corridors in the United States.” 2011. Masters Thesis, Virginia Tech. Accessed January 24, 2021. http://hdl.handle.net/10919/76794.

MLA Handbook (7^th Edition):

Vandyke, Alex J. “Development of a High-Speed Rail Model to Study Current and Future High-Speed Rail Corridors in the United States.” 2011. Web. 24 Jan 2021.

Vancouver:

Vandyke AJ. Development of a High-Speed Rail Model to Study Current and Future High-Speed Rail Corridors in the United States. [Internet] [Masters thesis]. Virginia Tech; 2011. [cited 2021 Jan 24]. Available from: http://hdl.handle.net/10919/76794.

Council of Science Editors:

Vandyke AJ. Development of a High-Speed Rail Model to Study Current and Future High-Speed Rail Corridors in the United States. [Masters Thesis]. Virginia Tech; 2011. Available from: http://hdl.handle.net/10919/76794

28. Ameur, Melissa. Les mécanismes d’initiation de la traduction de la polyprotéine Gag du Virus de l’Immunodéficience Humaine (VIH-1) : The translation initiation mechanisms of the Gag HIV-1 polyprotein.

Degree: Docteur es, Biologie moléculaire, 2016, Sorbonne Paris Cité

URL: http://www.theses.fr/2016USPCB125

► L'ARN génomique du Virus de l'Immunodéficience Humaine-1 (VIH-1) est multifonctionnel. Il constitue le génome encapsidé dans les virions et sert d'ARN messager pour la traduction… (more)

▼ L'ARN génomique du Virus de l'Immunodéficience Humaine-1 (VIH-1) est multifonctionnel. Il constitue le génome encapsidé dans les virions et sert d'ARN messager pour la traduction des protéines virales Gag et Gag-Pol. La traduction de ces protéines dépend exclusivement de la machinerie traductionnelle cellulaire et est initiée par deux mécanismes différents : l'initiation canonique dépendante de la coiffe et l'initiation par entrée interne des ribosomes (IRES). Le VIH-1 présente deux IRES, l'un dans la région 5' non traduite (5'-UTR) qui est stimulé en phase G2/M du cycle cellulaire et l'autre dans la région codante de Gag. Ce dernier permet l'initiation de la traduction sur deux AUG en phase et conduit à la production de la protéine Gag pleine longueur mais également à la production d'une isoforme alternative de Gag, tronquée en région N-terminale. Le rôle de cette isoforme reste mal connu. Toutefois la mutation du second AUG chez VIH-1 et donc la suppression de la seconde isoforme de Gag provoque une diminution importante du taux de la réplication virale. La conservation structurelle et fonctionnelle de l'IRES Gag parmi les lentivirus suggère un rôle important de cette isoforme et de l'IRES gag dans le cycle viral. Nos travaux visent à comprendre à un niveau moléculaire les relations hôtes-pathogènes lors de la traduction des messagers viraux. Je me suis particulièrement intéressée aux rôles de la sous unité ribosomale 40S et de l'hélicase cellulaire DDX3 dans l'initiation de la traduction de la polyprotéine Gag du VIH-1. La première partie de ma thèse est consacrée à l'étude de l'interaction entre la sous unité ribosomale 40S et l'IRES gag du VIH-1. Par l'utilisation d'approches complémentaires, nous avons pu démontrer la présence de deux sites distincts de liaison au ribosome qui sont présents à proximité des deux codons d'initiation. Nous avons ensuite évalué à la fois in vitro et in cellulo (en collaboration avec l'équipe de T. Ohlmann, CIRI-ENS-Lyon) l'effet de la délétion de chacun des sites de liaison au 40S sur l'efficacité de traduction de la polyprotéine Gag. Nos résultats valident l'importance fonctionnelle des sites de liaison au ribosome pour une production optimale des deux isoformes de la polyprotéine Gag. La seconde partie de mon travail a consisté à définir le rôle de DDX3 dans l'initiation « coiffe-dépendante » de la traduction de la polyprotéine Gag. DDX3 est une hélicase à ARN à boîte DEAD impliquée dans de nombreux processus cellulaires tels que la régulation du cycle cellulaire et la réponse immunitaire innée mais également dans tous les aspects du métabolisme de l'ARN comme la transcription, l'épissage, l'export nucléaire ou encore la traduction. Plus récemment, il a été montré que DDX3 est nécessaire à la traduction de l'ARN génomique du VIH-1, cependant son rôle exact n'a pas encore été défini. Nous avons purifié une forme recombinante de la protéine en fusion avec la MBP (Maltose Binding Protein) et effectué des cinétiques enzymatiques afin de caractériser ses propriétés biochimiques.… Advisors/Committee Members: Sargueil, Bruno (thesis director).

Subjects/Keywords: VIH-1; Traduction; IRES; Ribosomes; 40S; DEAD BOX; Hélicases; DDX3; Polyprotéine Gag; HIV-1; Translation; IRES; Ribosomes; 40S; DEAD BOX; Helicases; DDX3; Gag polyprotein; 572.8

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Ameur, M. (2016). Les mécanismes d’initiation de la traduction de la polyprotéine Gag du Virus de l’Immunodéficience Humaine (VIH-1) : The translation initiation mechanisms of the Gag HIV-1 polyprotein. (Doctoral Dissertation). Sorbonne Paris Cité. Retrieved from http://www.theses.fr/2016USPCB125

Chicago Manual of Style (16^th Edition):

Ameur, Melissa. “Les mécanismes d’initiation de la traduction de la polyprotéine Gag du Virus de l’Immunodéficience Humaine (VIH-1) : The translation initiation mechanisms of the Gag HIV-1 polyprotein.” 2016. Doctoral Dissertation, Sorbonne Paris Cité. Accessed January 24, 2021. http://www.theses.fr/2016USPCB125.

MLA Handbook (7^th Edition):

Ameur, Melissa. “Les mécanismes d’initiation de la traduction de la polyprotéine Gag du Virus de l’Immunodéficience Humaine (VIH-1) : The translation initiation mechanisms of the Gag HIV-1 polyprotein.” 2016. Web. 24 Jan 2021.

Vancouver:

Ameur M. Les mécanismes d’initiation de la traduction de la polyprotéine Gag du Virus de l’Immunodéficience Humaine (VIH-1) : The translation initiation mechanisms of the Gag HIV-1 polyprotein. [Internet] [Doctoral dissertation]. Sorbonne Paris Cité; 2016. [cited 2021 Jan 24]. Available from: http://www.theses.fr/2016USPCB125.

Council of Science Editors:

Ameur M. Les mécanismes d’initiation de la traduction de la polyprotéine Gag du Virus de l’Immunodéficience Humaine (VIH-1) : The translation initiation mechanisms of the Gag HIV-1 polyprotein. [Doctoral Dissertation]. Sorbonne Paris Cité; 2016. Available from: http://www.theses.fr/2016USPCB125

University of Illinois – Chicago

29. Clary, Lynn M. Function of conserved transcription factors in the C. elegans somatic gonad and pharynx.

Degree: 2012, University of Illinois – Chicago

URL: http://hdl.handle.net/10027/8916

► Mammalian EGR-family genes and T-box family genes are broadly expressed and mutants result in a variety of defects and diseases (O'Donovan et al., 1999). To… (more)

▼ Mammalian EGR-family genes and T-box family genes are broadly expressed and mutants result in a variety of defects and diseases (O'Donovan et al., 1999). To aid in our understanding of how these transcription factor families regulate gene expression we analyzed the function of C. elegans egrh-1 and tbx-2 in the somatic gonad and pharynx respectively. We found that the C. elegans Early Growth Response factor family member egrh-1 inhibits oocyte maturation and ovulation until sperm are available. C. elegans is an important system for addressing the fundamental events of oocyte meiotic maturation, ovulation and fertilization, complementing studies in vertebrate systems (Hubbard and Greenstein, 2000). In C. elegans oocyte production, maturation and ovulation must be coordinated with sperm availability for successful fertilization. egrh-1 mutants exhibit ectopic oocyte differentiation in the distal gonadal arm and accumulate abnormal and degraded oocytes proximally. These defects result in reduced brood size and partially penetrant embryonic lethality. Results of tissue-specific egrh-1(RNAi) experiments and genetic mosaic analyses revealed EGRH-1 function is necessary in the soma, and surprisingly this function is required in both the gut and the somatic gonad. Through transformation rescue experiments we show EGRH-1 in the somatic gonad inhibits oocyte maturation, ovulation and sperm recruitment. The T-box family member TBX-2 is the sole C. elegans member of the conserved Tbx2 sub-family. It has been previously shown that C. elegans TBX-2 is required for the development of ABa-derived pharyngeal muscles; however it is not known how TBX-2 specifically regulates the development of these cells. We are interested in identifying TBX-2 targets that function in pharyngeal muscle development, and in determining if TBX-2 is a transcriptional activator or repressor. To identify targets of TBX-2, we have compared mRNA expression levels in wild-type and tbx-2(bx59) mutant embryos using Affymetrix microarrays. Of 19,885 probe sets examined, we found 980 mRNAs that were significantly up-regulated in tbx-2(bx59) relative to wild-type and 175 mRNAs that were significantly down-regulated. Using clustering analysis, comparisons to existing data sets on pharyngeal gene expression, and phylogenetic foot-printing to identify promoters with consensus T-box factor binding sites, we have analyzed a subset of genes and identified D2096.6 as a direct target of TBX-2. Our data indicate that D2096.6 is directly repressed by TBX-2 at a variant T-box binding site in the D2096.6 promoter. Advisors/Committee Members: Schmidt, Jennifer (advisor), Okkema, Peter (committee member), Alfonso, Aixa (committee member), Morrison, Don (committee member), Frolov, Maxim (committee member).

Subjects/Keywords: EGRH-1; early growth response; somatic gonad; TBX-2; T-box; pharynx; C. elegans

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APA (6^th Edition):

Clary, L. M. (2012). Function of conserved transcription factors in the C. elegans somatic gonad and pharynx. (Thesis). University of Illinois – Chicago. Retrieved from http://hdl.handle.net/10027/8916

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Clary, Lynn M. “Function of conserved transcription factors in the C. elegans somatic gonad and pharynx.” 2012. Thesis, University of Illinois – Chicago. Accessed January 24, 2021. http://hdl.handle.net/10027/8916.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Clary, Lynn M. “Function of conserved transcription factors in the C. elegans somatic gonad and pharynx.” 2012. Web. 24 Jan 2021.

Vancouver:

Clary LM. Function of conserved transcription factors in the C. elegans somatic gonad and pharynx. [Internet] [Thesis]. University of Illinois – Chicago; 2012. [cited 2021 Jan 24]. Available from: http://hdl.handle.net/10027/8916.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Clary LM. Function of conserved transcription factors in the C. elegans somatic gonad and pharynx. [Thesis]. University of Illinois – Chicago; 2012. Available from: http://hdl.handle.net/10027/8916

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Minnesota

30. Chiang, Hung-Sheng. Nonlinear transport in two-dimensional electron gas at large filling factors.

Degree: PhD, Physics, 2011, University of Minnesota

URL: http://purl.umn.edu/104634

► We studied nonlinear electrical transport in high-mobility 2D electron gas (2DEG) forming in modulation-doped GaAs/AlGaAs quantum wells. Transport nonlinearities induced by a pure dc electric… (more)

Subjects/Keywords: 2DEG; High filling factor; High mobility; Nonlinear transport; Physics

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Chiang, H. (2011). Nonlinear transport in two-dimensional electron gas at large filling factors. (Doctoral Dissertation). University of Minnesota. Retrieved from http://purl.umn.edu/104634

Chicago Manual of Style (16^th Edition):

Chiang, Hung-Sheng. “Nonlinear transport in two-dimensional electron gas at large filling factors.” 2011. Doctoral Dissertation, University of Minnesota. Accessed January 24, 2021. http://purl.umn.edu/104634.

MLA Handbook (7^th Edition):

Chiang, Hung-Sheng. “Nonlinear transport in two-dimensional electron gas at large filling factors.” 2011. Web. 24 Jan 2021.

Vancouver:

Chiang H. Nonlinear transport in two-dimensional electron gas at large filling factors. [Internet] [Doctoral dissertation]. University of Minnesota; 2011. [cited 2021 Jan 24]. Available from: http://purl.umn.edu/104634.

Council of Science Editors:

Chiang H. Nonlinear transport in two-dimensional electron gas at large filling factors. [Doctoral Dissertation]. University of Minnesota; 2011. Available from: http://purl.umn.edu/104634

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