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1. Mitrović Olivera. Correlation between protein and gene expression of HER-2 and topoisomerase 2a in infiltrative ductal breast carcinoma.

Degree: PhD, Biology, 2013, University of Belgrade

Introduction: Breast cancer is a heterogeneous disease and the most common malignancy in women with increasing incidence in recent years. According to immunohistochemical expression of estrogen receptor (ER-R), progesterone receptor (PR-R) and HER-2 four different molecular subtypes of breast cancer were identified: luminal A (ER-R+ and / or PR-R+, HER-2-), luminal B (ER-R+ and / or PR-R+, HER- 2+), HER-2 positive (ER-R- and / or PR-R-, HER-2+) and triple negative (ER-R- and / or PR-R-, HER-2-) breast cancer subtypes. HER-2 and TOP2A genes are amplified in 20– 30 % of breast cancers. Amplification of HER-2 and TOP2A genes are associated with a poor prognosis and predictive response to treatment by Herceptin and anthracycline. Co-amplification of HER-2 and TOP2A has been seen in approximately 12–38 % of patients with breast cancers. A few retrospective studies have reported that TOP2A gene amplification occurs almost exclusively in conjunction with HER-2 gene amplification. Aim: The aim of our study is to investigate HER-2 and TOP2A gene aberrations and their correlation with apoptotic and proliferative indexes, Bcl-2, p53, ER-R, PR-R, HER-2, TOP2A, BRCA1, clinicopathological parameters and overall survival in four molecular subtypes of breast cancer. Material and methods: Sixty paraffin-embedded breast cancer tissue samples were studied immunohistochemically for the expression of ER-R, PR-R, HER-2, p53, Bcl-2, ssDNA, Ki67, BRCA1, TOP2A and FISH for HER-2 and TOP2A gene aberrations. HER-2 and TOP2A gene copy number were analyzed by HER-2 FISH pharmDxTM kit and TOP2A FISH pharmDxTM kit (DakoCytomation), respectively. Results: Clinicopathological parameters - The ages of patients ranged from 38 to 87 years (64.79 ± 21). The tumor size ranged between 0.4 and 5.5 cm, and the histological grades were G1, G2 and G3 in 6 (10 %), 25 (41.7 %), and 17 (28.3 %) patients, respectively. In 26 patients (43.4 %) lymph node status was negative; while in 22 patients (36.6 %) was detected positive lymph node status. Distant metastasis characterized 7 (15.3 %) patients and in 39 (84.7 %) patients we did not find a distant metastasis. HER-2 and TOP2A gene aberrations in four molecular subtypes of breast cancer - Among 24 patients of luminal A subtype, only in one case (1/24, 4.2 %) a low level of HER-2 gene amplification was detected, while 3 cases (3/24, 12.5 %) were highly amplified for TOP2A, 5 cases (5/24, 20.8 %) had low level of TOP2A gene amplification and in one case (1/24, 4.2 %) TOP2A gene deletion was detected. We characterized 5 cases with low (5/26, 19.3 %) and 6 cases with high (6/26, 23 %) level of HER-2 gene amplification in total 26 patients of luminal B subtype of breast cancer. In the same subtype, a low level of TOP2A gene amplification was detected in 6 cases (6/26, 23.1 %), high level in 5 cases (5/26, 19.2 %) and in 4 cases (4/26, 15.4 %) were detected TOP2A gene deletion. In patients with triple negative subtypes of breast cancer, only one case (1/4, 25 %) had a low level of TOP2A gene amplification whereas…

Subjects/Keywords: molecular subtypes of breast cancer; HER-2 and TOP2A gene aberrations; ER-R; PR-R; HER-2; p53; Bcl-2; TOP2A; BRCA1; Ki67 and ssDNA expression; molekularni tipovi karcinoma dojke; HER-2 i TOP2A genske aberacije; ER-R; PR-R; HER-2; TOP2A; BRCA1; p53; Bcl-2; Ki67 i ssDNA imunohistohemijska ekspresija

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APA (6th Edition):

Olivera, M. (2013). Correlation between protein and gene expression of HER-2 and topoisomerase 2a in infiltrative ductal breast carcinoma. (Doctoral Dissertation). University of Belgrade. Retrieved from http://dx.doi.org/10.2298/BG20131101MITROVIC ; http://eteze.bg.ac.rs/application/showtheses?thesesId=883 ; https://fedorabg.bg.ac.rs/fedora/get/o:7287/bdef:Content/get ; http://vbs.rs/scripts/cobiss?command=SEARCH&base=99999&select=ID=44859407

Chicago Manual of Style (16th Edition):

Olivera, Mitrović. “Correlation between protein and gene expression of HER-2 and topoisomerase 2a in infiltrative ductal breast carcinoma.” 2013. Doctoral Dissertation, University of Belgrade. Accessed August 18, 2019. http://dx.doi.org/10.2298/BG20131101MITROVIC ; http://eteze.bg.ac.rs/application/showtheses?thesesId=883 ; https://fedorabg.bg.ac.rs/fedora/get/o:7287/bdef:Content/get ; http://vbs.rs/scripts/cobiss?command=SEARCH&base=99999&select=ID=44859407.

MLA Handbook (7th Edition):

Olivera, Mitrović. “Correlation between protein and gene expression of HER-2 and topoisomerase 2a in infiltrative ductal breast carcinoma.” 2013. Web. 18 Aug 2019.

Vancouver:

Olivera M. Correlation between protein and gene expression of HER-2 and topoisomerase 2a in infiltrative ductal breast carcinoma. [Internet] [Doctoral dissertation]. University of Belgrade; 2013. [cited 2019 Aug 18]. Available from: http://dx.doi.org/10.2298/BG20131101MITROVIC ; http://eteze.bg.ac.rs/application/showtheses?thesesId=883 ; https://fedorabg.bg.ac.rs/fedora/get/o:7287/bdef:Content/get ; http://vbs.rs/scripts/cobiss?command=SEARCH&base=99999&select=ID=44859407.

Council of Science Editors:

Olivera M. Correlation between protein and gene expression of HER-2 and topoisomerase 2a in infiltrative ductal breast carcinoma. [Doctoral Dissertation]. University of Belgrade; 2013. Available from: http://dx.doi.org/10.2298/BG20131101MITROVIC ; http://eteze.bg.ac.rs/application/showtheses?thesesId=883 ; https://fedorabg.bg.ac.rs/fedora/get/o:7287/bdef:Content/get ; http://vbs.rs/scripts/cobiss?command=SEARCH&base=99999&select=ID=44859407


Bowling Green State University

2. Ratcliffe, Viola. To Be A Witness: Lynching and Postmemory in LaShawnda Crowe Storm's "Her Name Was Laura Nelson".

Degree: MA, Art/Art History, 2015, Bowling Green State University

The literal reframing of the lynching postcard The Lynching of Laura Nelson within the medium of quilting allows for a visual re-contextualization of this image’s history. In LaShawnda Crowe Storm’s Quilt I: Her Name Was Laura Nelson the confrontation between viewers and the lynched body of an African American woman addresses an often neglected phenomenon, the lynching of black women in the United States during the late 19th and early 20th century. The literal reframing of the lynching postcard The Lynching of Laura Nelson within the medium of quilting allows for a visual re-contextualization of this image’s history. In the act of quilting Crowe Storm has removed this image from its original intention, a form of propaganda used to fuel racist ideology, and has now placed it within a context of feminism, activism, and communal art making. The selection of the medium of quilting in this work was intentional. In quilting LaShawnda Crowe Storm situates the work, and its attendant imagery, within a dialogue regarding female identity, the construction of community and the history of racial violence in the United States. As a community leader and activist in the city of Indianapolis, Indiana, LaShawnda Crowe Storm developed The Lynch Quilts Project as a means to bring people from across the country together to have an honest dialogue about the legacy of lynching and racial violence in the United States. The project was developed in 2004 and is a twenty-first century quilting collective that has manifested into a social justice movement. This paper investigates the strategies by which LaShawnda Crowe Storm’s Her Name Was Laura Nelson engages viewers to construct an ethical relationship with the history of lynching in the United States and fosters the production of postmemory. Coined by the Holocaust scholar Marianne Hirsch,“Postmemory describes the relationship that the generation after those who witnessed cultural or collective trauma bears to the experiences of those who came before, experiences that they can `remember’ only by the means of the stories, images and behaviors among which they grew up. But these experiences were transmitted to them so deeply that they seem to constitute memories in their own right.” As this essay argues, Crowe Storm’s appropriation of the lynch photograph of Laura Nelson into the artistic form of a quilted textile enables this often unspoken history to be transmitted generationally. By analyzing this history of racial violence through the lens of postmemory, readers will not only have a greater perception of why this type of violence continues to manifest on modern society, but also the ramifications that racial violence continues to have today. Advisors/Committee Members: Skinner Greene, Rebecca L. (Committee Chair), Terry-Fritsch, Allison (Advisor).

Subjects/Keywords: Art History; Black Studies; African Americans; lynching; LaShawnda Crowe Storm; Quilt I Her Name Was Laura Nelson; quilts; African American women; communal art-making; The Lynch Quilts Project

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APA (6th Edition):

Ratcliffe, V. (2015). To Be A Witness: Lynching and Postmemory in LaShawnda Crowe Storm's "Her Name Was Laura Nelson". (Masters Thesis). Bowling Green State University. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1435789289

Chicago Manual of Style (16th Edition):

Ratcliffe, Viola. “To Be A Witness: Lynching and Postmemory in LaShawnda Crowe Storm's "Her Name Was Laura Nelson".” 2015. Masters Thesis, Bowling Green State University. Accessed August 18, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1435789289.

MLA Handbook (7th Edition):

Ratcliffe, Viola. “To Be A Witness: Lynching and Postmemory in LaShawnda Crowe Storm's "Her Name Was Laura Nelson".” 2015. Web. 18 Aug 2019.

Vancouver:

Ratcliffe V. To Be A Witness: Lynching and Postmemory in LaShawnda Crowe Storm's "Her Name Was Laura Nelson". [Internet] [Masters thesis]. Bowling Green State University; 2015. [cited 2019 Aug 18]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1435789289.

Council of Science Editors:

Ratcliffe V. To Be A Witness: Lynching and Postmemory in LaShawnda Crowe Storm's "Her Name Was Laura Nelson". [Masters Thesis]. Bowling Green State University; 2015. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1435789289


Universitat de Barcelona

3. Anido Folgueira, Judit. Nuevos mecanismos de tumorgènesis del protooncogén HER2. Implicaciones terapéuticas en cáncer de mama.

Degree: Departament de Genètica, 2006, Universitat de Barcelona

<I>The HER1 and HER2 are frequently overexpressed in breast cancer, and their overexpression is associated with a more aggressive clinical behavior. As a consequence, different compounds targeting these receptors have been developed as a fruitful approach to the therapy of breast cancer. One example is Iressa, an oral nonpeptide compound that selectively inhibits the TK activity of HER1; or Herceptin, a monoclonal antibody that targets HER2. To characterize the potential role of Iressa in the treatment of breast cancer, we have studied its effects in a variety of breast carcinoma cell lines expressing different levels of HER1 and HER2 receptors. Our studies demonstrate that Iressa, despite being a specific inhibitor of the EGFR TK, is a potent inhibitor of HER2-over expressing breast cancer cells. We have demonstrated that these effects are explained by a novel and double mechanisms of action. Iressa inhibits the quinase activity of HER1 in one hand and promotes the formation of inactive (unphosphorylated) HER1/HER2 and HER2/ HER3 heterodimers on the other. In the second part of this work we have characterized the CTFs (Carboxi-terminal fragments) of HER2, a truncated form of the HER2 receptor encoding its cytoplasmic domain. CTFs are frequently found in human mammary tumors and associate with nodal metastasis and poor prognosis. However the mechanism of generation is not understood. Here we show that HER2 CTFs are generated by alternative initiation of translation from methionines located near the transmembrana domain of the full-length molecule. In vitro and in vivo, HER2 CTFs are found in the cytoplasm and nucleus. Expression of HER2 CTFs induces the growth of breast cancer xenografts in nude mice. Tumors dependent on CTFs are sensitive to inhibitors of the kinase activity but do not respond to Herceptin. Thus, the kinase domain seems necessary for the activity of HER2 CTFs and the presence of the CTFs could account for the resistance to treatment with Herceptin. </I> Advisors/Committee Members: [email protected] (authoremail), true (authoremailshow), Baselga Torres, Josep, 1959- (director), Arribas, Joaquín V. (Vicente) (director), Balcells Comas, Susana (tutor).

Subjects/Keywords: Tumorgènesi; Oncologia; Tirosines HER; Activitat quinasa; Ciències Experimentals i Matemàtiques; 575

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Anido Folgueira, J. (2006). Nuevos mecanismos de tumorgènesis del protooncogén HER2. Implicaciones terapéuticas en cáncer de mama. (Thesis). Universitat de Barcelona. Retrieved from http://hdl.handle.net/10803/1878

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Anido Folgueira, Judit. “Nuevos mecanismos de tumorgènesis del protooncogén HER2. Implicaciones terapéuticas en cáncer de mama.” 2006. Thesis, Universitat de Barcelona. Accessed August 18, 2019. http://hdl.handle.net/10803/1878.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Anido Folgueira, Judit. “Nuevos mecanismos de tumorgènesis del protooncogén HER2. Implicaciones terapéuticas en cáncer de mama.” 2006. Web. 18 Aug 2019.

Vancouver:

Anido Folgueira J. Nuevos mecanismos de tumorgènesis del protooncogén HER2. Implicaciones terapéuticas en cáncer de mama. [Internet] [Thesis]. Universitat de Barcelona; 2006. [cited 2019 Aug 18]. Available from: http://hdl.handle.net/10803/1878.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Anido Folgueira J. Nuevos mecanismos de tumorgènesis del protooncogén HER2. Implicaciones terapéuticas en cáncer de mama. [Thesis]. Universitat de Barcelona; 2006. Available from: http://hdl.handle.net/10803/1878

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

.