subject:(Hepatitis B)

University of Namibia

1. Mhata, Petrus. Investigation into Hepatitis B virus prevalence, risk factors and health care workers' awareness in Kavango East And West regions of Namibia.

Degree: 2018, University of Namibia

URL: http://hdl.handle.net/11070/2459

► Available data has shown that most deaths due to liver cancer and cirrhosis are primarily attributed to the complications of Hepatitis B Virus (HBV) infections,… (more)

▼ Available data has shown that most deaths due to liver cancer and cirrhosis are primarily attributed to the complications of Hepatitis B Virus (HBV) infections, globally. Countries ought to have well-documented information on the HBV prevalence and risk factors to be able to understand and interrupt its transmission. In Namibia, data on the HBV prevalence and risk factors are scanty and older than two decades. Also, health care workers’ (HCWs) awareness on the HBV prevention and control are inadequate. The purpose of this study was to investigate HBV prevalence, risk factors and health care workers’ awareness on HBV prevention and control aspects in Kavango East and West (KE&W) regions. The study adopted a quantitative, cross-sectional, descriptive and analytical design. Firstly, the researcher interviewed purposively selected HCWs from the Ministry of Health (17 respondents) and private health clinicians (13 respondents) about their awareness on HBV. Next, all the pre-existing HBV laboratory results from Namibia Institute of Pathology (NIP), January-December 2013 were retrieved and analyzed. Thereafter, a population-based survey, which included 720 randomly selected subject individuals from 20 households in 36 lusters in KE&W regions, was conducted, by interviewing respondents or their caretakers. One drop of blood was drawn from each respondent and was tested for hepatitis B surface antigen, using Uni-Gold HBV rapid diagnostic kits. All the responses were analyzed using the Statistical Package for the Social Science (SPSS) software, version 24. The frequencies, cross-tabulations, logistic regression, bivariate and risk factor analysis were performed. Based on this analysis, the health care workers’ awareness on HBV prevention, were found to be insufficient. The pre-existing HBV laboratory results showed HBV positivity rate of 11.8% nationally, with Kavango region showing the highest prevalence of 16.3%. The HBV prevalence survey in KE&W regions showed an overall prevalence of 7.1% for the two regions combined, but when disaggregated by region, Kavango West showed 12.3%, compared to5.0% of Kavango East. Further analysis has shown a strong association between positive results with rural residents (p=0.007), household contacts or providers of care for HBV infected person (p=0.000), sex work for money (p=0.001) and age at first sex (p=0.002).A predictive model, based on selected variables, whether or not someone is likely to be HBV positive has been developed. The study proposed recommendations to the MoHSS and related stakeholders to develop a strategic plan to combat viral hepatitis in Namibia in general and in KE&W regions in particular.

Subjects/Keywords: Hepatitis B

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APA (6^th Edition):

Mhata, P. (2018). Investigation into Hepatitis B virus prevalence, risk factors and health care workers' awareness in Kavango East And West regions of Namibia. (Thesis). University of Namibia. Retrieved from http://hdl.handle.net/11070/2459

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Mhata, Petrus. “Investigation into Hepatitis B virus prevalence, risk factors and health care workers' awareness in Kavango East And West regions of Namibia.” 2018. Thesis, University of Namibia. Accessed January 22, 2021. http://hdl.handle.net/11070/2459.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Mhata, Petrus. “Investigation into Hepatitis B virus prevalence, risk factors and health care workers' awareness in Kavango East And West regions of Namibia.” 2018. Web. 22 Jan 2021.

Vancouver:

Mhata P. Investigation into Hepatitis B virus prevalence, risk factors and health care workers' awareness in Kavango East And West regions of Namibia. [Internet] [Thesis]. University of Namibia; 2018. [cited 2021 Jan 22]. Available from: http://hdl.handle.net/11070/2459.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Mhata P. Investigation into Hepatitis B virus prevalence, risk factors and health care workers' awareness in Kavango East And West regions of Namibia. [Thesis]. University of Namibia; 2018. Available from: http://hdl.handle.net/11070/2459

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Melbourne

2. Lim, Lucy. The role of Hepatitis B surface antigen in the development of severe liver disease and hepatocellular carcinoma.

Degree: 2016, University of Melbourne

URL: http://hdl.handle.net/11343/129770

► Hepatitis B virus (HBV) infection continues to be a major public health issue worldwide, affecting an estimated 2 billion people globally. In spite of safe… (more)

▼ Hepatitis B virus (HBV) infection continues to be a major public health issue worldwide, affecting an estimated 2 billion people globally. In spite of safe vaccination and effective therapy, there is still a large burden of disease due to chronic hepatitis B (CHB), affecting an estimated 240 million people, which may lead to cirrhosis and or the development of hepatocellular carcinoma (HCC). Liver cancer is rapidly emerging as the single greatest challenge in hepatology and liver transplantation and the burden of disease is set to explode in the next 20-30 years. Viral hepatitis is ranked as the seventh leading cause of death worldwide, resulting in at least 1.2 million deaths annually from liver cirrhosis and HCC. HCC is currently the sixth most common cancer and the second leading cause of cancer-related deaths globally. Case-control studies have shown that chronic HBV carriers have more than 100-fold increased risk of HCC compared with non-infected individuals. Approximately 80% of all HCC cases can be attributed to viral hepatitis, more than half of that due to HBV, which is the second most potent carcinogen after tobacco (World Health Organization), and this is despite remarkable improvement in therapy with the advent of nucleos(t)ide analogues (NA). The global reservoir of HBV infection serves as the basis for the generation of HBV variants via recombination and a high frequency of mutation in the HBV genome. Due to the inherent molecular biology of this virus which replicates its DNA genome via a low fidelity viral reverse transcriptase (rt)/polymerase, a population of closely related genetic variants known as a quasispecies is produced. The last two decades have seen a significant increase in the emergence of mutants as the virus responds to selective pressures, such as vaccination and antiviral therapy. Surveillance for clinically significant HBV mutations and an improved understanding of the impact of these emerging variants on the natural history of the disease and its diagnosis, control and management will pose a challenge to global health care in the foreseeable future. This is because these mutants have the potential to alter current diagnostic and treatment algorithms. NA therapy was approved in 1998, which efficiently lowers the HBV DNA viral load in HBV-infected patients. Given that the HCC risk is particularly high in the presence of cirrhosis and/or persistent high HBV DNA replication, NA should be a rational treatment to prevent liver disease progression including liver cancer in such patients. However since the introduction of antiviral therapy, the HCC incidence has continued to rise. Registration for the liver transplant waiting list due to HBV-related HCC in the U.S. has increased in the NA era, which may in part be due to patients no longer dying of liver disease. There is clearly a need for a greater understanding of the role that NA therapy might play in the development of HCC. Numerous risk factors for HBV-related HCC development have been identified. However the…

Subjects/Keywords: Hepatitis B

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APA (6^th Edition):

Lim, L. (2016). The role of Hepatitis B surface antigen in the development of severe liver disease and hepatocellular carcinoma. (Doctoral Dissertation). University of Melbourne. Retrieved from http://hdl.handle.net/11343/129770

Chicago Manual of Style (16^th Edition):

Lim, Lucy. “The role of Hepatitis B surface antigen in the development of severe liver disease and hepatocellular carcinoma.” 2016. Doctoral Dissertation, University of Melbourne. Accessed January 22, 2021. http://hdl.handle.net/11343/129770.

MLA Handbook (7^th Edition):

Lim, Lucy. “The role of Hepatitis B surface antigen in the development of severe liver disease and hepatocellular carcinoma.” 2016. Web. 22 Jan 2021.

Vancouver:

Lim L. The role of Hepatitis B surface antigen in the development of severe liver disease and hepatocellular carcinoma. [Internet] [Doctoral dissertation]. University of Melbourne; 2016. [cited 2021 Jan 22]. Available from: http://hdl.handle.net/11343/129770.

Council of Science Editors:

Lim L. The role of Hepatitis B surface antigen in the development of severe liver disease and hepatocellular carcinoma. [Doctoral Dissertation]. University of Melbourne; 2016. Available from: http://hdl.handle.net/11343/129770

3. Umeh, Uwaezu J. Improving Chronic Hepatitis B Virus Screening at a Safety-Net Primary Care Clinic.

Degree: DNP, Nursing, 2019, University of San Francisco

URL: https://repository.usfca.edu/dnp/192

► Hepatitis B Virus (HBV) is a type of virus that affects the liver. Chronic hepatitis B is usually asymptomatic and many HBV carriers remain… (more)

▼ Hepatitis B Virus (HBV) is a type of virus that affects the liver. Chronic hepatitis B is usually asymptomatic and many HBV carriers remain unaware of their viral status, thereby may unknowingly transmit the disease. If left untreated or undetected, it could lead to cirrhosis, hepatocellular carcinoma or mortality. Although this virus is endemic in some parts of the world such as Asia and Africa, it is important to note that HBV has become a global problem. The Centers for Disease Control and Prevention (CDC) in conjunction with the United States Preventive Services Task Force (USPSTF) estimates that about 700,000 to 2.2 million people in the United States have chronic hepatitis B (CHB) and about 14,000 die yearly as a result of complications from the virus. Hence, they recommend that screening be offered to individuals at high risk for hepatitis B virus. People at risk include but are not limited to individuals born in countries of high HBV endemicity (³2%), injection drug users, men who have sex with men, HIV positive patients, household and sexual contacts of people with HBV, individuals who are incarcerated, and people infected with hepatitis C virus. This Doctor of Nursing Practice (DNP) quality improvement project was conducted at the Order of Malta Clinic in Oakland, California, a safety-net clinic that provides free health care services to individuals who are uninsured, low income and the working poor in the community. This clinic serves a huge population of immigrants (about 90% of their patient population) eligible for chronic hepatitis B screening but based on observations and review of patients’ chart, it was noted that only about 33% of eligible patients were screened. There is currently no protocol for chronic hepatitis B screening at this clinic, instead patients are screened based on presenting symptoms. Hence, this project sought to improve the screening rates for chronic hepatitis B from 33% to 70% at the Order of Malta clinic using the HBsAg blood test by October 2019. This was accomplished by interviewing the providers individually and providing in-service training to physicians and nurse practitioners on the current HBV screening guidelines. A random retrospective review of patients’ chart was done in order to get a sense of the overall percentage of eligible patients that were screened. This included a 3-4 weeks of intervention period and 10 weeks of implementation. After the intervention and implementation, patients’ charts were once again randomly reviewed in order to evaluate the outcome of the project. The motivation for carrying out this project was to improve the screening rate for chronic hepatitis B, and treat individuals with a positive result so as to delay or prevent the sequelae that comes with the virus. The long-term benefit would be to improve overall health and wellbeing, and also decrease the cost of treating hepatitis B associated complications such as cirrhosis, liver failure and liver cancer. … Advisors/Committee Members: Dr. Jo Loomis, Dr. Stefan Rowniak.

Subjects/Keywords: Hepatitis; chronic hepatitis B; hepatitis B virus; hepatitis B infection; hepatitis B prevention and hepatitis B vaccination; Nursing

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APA (6^th Edition):

Umeh, U. J. (2019). Improving Chronic Hepatitis B Virus Screening at a Safety-Net Primary Care Clinic. (Thesis). University of San Francisco. Retrieved from https://repository.usfca.edu/dnp/192

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Umeh, Uwaezu J. “Improving Chronic Hepatitis B Virus Screening at a Safety-Net Primary Care Clinic.” 2019. Thesis, University of San Francisco. Accessed January 22, 2021. https://repository.usfca.edu/dnp/192.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Umeh, Uwaezu J. “Improving Chronic Hepatitis B Virus Screening at a Safety-Net Primary Care Clinic.” 2019. Web. 22 Jan 2021.

Vancouver:

Umeh UJ. Improving Chronic Hepatitis B Virus Screening at a Safety-Net Primary Care Clinic. [Internet] [Thesis]. University of San Francisco; 2019. [cited 2021 Jan 22]. Available from: https://repository.usfca.edu/dnp/192.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Umeh UJ. Improving Chronic Hepatitis B Virus Screening at a Safety-Net Primary Care Clinic. [Thesis]. University of San Francisco; 2019. Available from: https://repository.usfca.edu/dnp/192

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Adelaide

4. Teoh, Chee Quin (Devin). Development and assessment of novel vaccination strategies for hepatitis B virus infection.

Degree: 2014, University of Adelaide

URL: http://hdl.handle.net/2440/92807

► The current hepatitis B virus (HBV) vaccine is of no benefit in the treatment of patients with chronic HBV infection, and current antiviral therapies which… (more)

▼ The current hepatitis B virus (HBV) vaccine is of no benefit in the treatment of patients with chronic HBV infection, and current antiviral therapies which inhibit the virus polymerase are not highly effective. The ultimate aim of this Ph.D. project was to develop and assess therapeutic vaccination strategies that induce immune responses that target virus infected hepatocytes and allow successful control of chronic HBV infection. To this end, a number of vaccination strategies were tested using the duck hepatitis B virus (DHBV) model. The DHBV model provides a versatile and reproducible experimental system for testing vaccination strategies as the outcomes of DHBV infection in ducks of different ages infected with different doses of virus have been well characterised. In initial studies described in Chapter 3, recombinant DHBV core antigen (rDHBcAg) expressed in E. coli, was purified and used to immunise rabbits and mice to produce specific polyclonal and monoclonal antibodies for the detection of DHBV core antigen (DHBcAg). Immuno-staining techniques using these anti-DHBcAg-specific antibodies were then optimised. Immunoperoxidase detection of DHBcAg in duck liver sections was an essential part of this analysis as it allowed comparison with detection of DHBV surface antigen (DHBsAg) and confirmation of the percentage of DHBV-infected hepatocytes. Western Blot and immunofluorescent detection of DHBcAg were also developed and optimised and then all 3 immuno-staining techniques were used in subsequent Chapters to assess the efficacy of the different vaccination strategies. As described in Chapter 4, duck CD40L (DuCD40L), was assessed as an immunological adjuvant in a protective DNA vaccine study. In humans, CD40L acts as a co-stimulatory molecule in the CD40-signalling pathway that is involved in the activation of antigen presenting cells (APC) and the generation of humoral and cell mediated immune (CMI) responses. In the current studies the DuCD40L cDNA sequence was cloned using mRNA from duck peripheral blood mononuclear cells (PBMC) into the expression construct, pcDNA3, to yield pcDNA3-DuCD40L. Cells and supernatants of cells transfected with pcDNA3-DuCD40L were subsequently tested for bioactivity using in vitro assays. The cloning and analysis of expression of the DuCD40L was performed in our laboratory by Dr Feng Feng. The DuCD40L expression construct was then co-administered intramuscularly with DNA vaccines expressing the DHBV surface and core antigens to ducks at 14 and 28 days of age. Two weeks after the second vaccination, ducks were challenged intravenously (i.v.) with 4.5x10¹⁰ DHBV genomes. Administration of the DuCD40L expression construct and the DHBV DNA vaccines in combination resulted in a 10-fold greater anti-DHBs antibody response and a significant decrease in the number of DHBV-infected hepatocytes at day 4 post-challenge (p.c.) compared to ducks that received DHBV DNA vaccines alone. Ultimately, as expected, all of the ducks successfully cleared their DHBV infection. Nevertheless, we determined… Advisors/Committee Members: Jilbert, Allison Rae (advisor), Feng, Feng (advisor), School of Molecular and Biomedical Science (school).

Subjects/Keywords: Hepatitis B; Vaccination

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APA (6^th Edition):

Teoh, C. Q. (. (2014). Development and assessment of novel vaccination strategies for hepatitis B virus infection. (Thesis). University of Adelaide. Retrieved from http://hdl.handle.net/2440/92807

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Teoh, Chee Quin (Devin). “Development and assessment of novel vaccination strategies for hepatitis B virus infection.” 2014. Thesis, University of Adelaide. Accessed January 22, 2021. http://hdl.handle.net/2440/92807.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Teoh, Chee Quin (Devin). “Development and assessment of novel vaccination strategies for hepatitis B virus infection.” 2014. Web. 22 Jan 2021.

Vancouver:

Teoh CQ(. Development and assessment of novel vaccination strategies for hepatitis B virus infection. [Internet] [Thesis]. University of Adelaide; 2014. [cited 2021 Jan 22]. Available from: http://hdl.handle.net/2440/92807.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Teoh CQ(. Development and assessment of novel vaccination strategies for hepatitis B virus infection. [Thesis]. University of Adelaide; 2014. Available from: http://hdl.handle.net/2440/92807

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Georgia Tech

5. Perez Cuevas, Monica Beatriz. Hepatitis B vaccination using a dissolvable microneedle patch.

Degree: MS, Chemical and Biomolecular Engineering, 2017, Georgia Tech

URL: http://hdl.handle.net/1853/59807

► Despite improved vaccination rates against hepatitis B, there remain critical barriers to addressing gaps in vaccination coverage. The need of an effective supply chain, vaccine… (more)

Subjects/Keywords: Microneedles; Hepatitis b

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APA (6^th Edition):

Perez Cuevas, M. B. (2017). Hepatitis B vaccination using a dissolvable microneedle patch. (Masters Thesis). Georgia Tech. Retrieved from http://hdl.handle.net/1853/59807

Chicago Manual of Style (16^th Edition):

Perez Cuevas, Monica Beatriz. “Hepatitis B vaccination using a dissolvable microneedle patch.” 2017. Masters Thesis, Georgia Tech. Accessed January 22, 2021. http://hdl.handle.net/1853/59807.

MLA Handbook (7^th Edition):

Perez Cuevas, Monica Beatriz. “Hepatitis B vaccination using a dissolvable microneedle patch.” 2017. Web. 22 Jan 2021.

Vancouver:

Perez Cuevas MB. Hepatitis B vaccination using a dissolvable microneedle patch. [Internet] [Masters thesis]. Georgia Tech; 2017. [cited 2021 Jan 22]. Available from: http://hdl.handle.net/1853/59807.

Council of Science Editors:

Perez Cuevas MB. Hepatitis B vaccination using a dissolvable microneedle patch. [Masters Thesis]. Georgia Tech; 2017. Available from: http://hdl.handle.net/1853/59807

University of Zambia

6. Mungandi, Namwaka. Hepatitis B Vaccination coverage and the determinants of vaccination in Health Care Workers in seleted Health facilities .

Degree: 2017, University of Zambia

URL: http://dspace.unza.zm:8080/xmlui/handle/123456789/4868

► Background: Hepatitis B is a viral infection of the liver and causes both acute and chronic disease. It is transmitted through contact with an infected… (more)

Subjects/Keywords: Hepatitis B-Lusaka,Zambia; Hepatitis B-Vaccination-Lusaka,Zambia; Hepatitis B

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APA (6^th Edition):

Mungandi, N. (2017). Hepatitis B Vaccination coverage and the determinants of vaccination in Health Care Workers in seleted Health facilities . (Thesis). University of Zambia. Retrieved from http://dspace.unza.zm:8080/xmlui/handle/123456789/4868

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Mungandi, Namwaka. “Hepatitis B Vaccination coverage and the determinants of vaccination in Health Care Workers in seleted Health facilities .” 2017. Thesis, University of Zambia. Accessed January 22, 2021. http://dspace.unza.zm:8080/xmlui/handle/123456789/4868.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Mungandi, Namwaka. “Hepatitis B Vaccination coverage and the determinants of vaccination in Health Care Workers in seleted Health facilities .” 2017. Web. 22 Jan 2021.

Vancouver:

Mungandi N. Hepatitis B Vaccination coverage and the determinants of vaccination in Health Care Workers in seleted Health facilities . [Internet] [Thesis]. University of Zambia; 2017. [cited 2021 Jan 22]. Available from: http://dspace.unza.zm:8080/xmlui/handle/123456789/4868.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Mungandi N. Hepatitis B Vaccination coverage and the determinants of vaccination in Health Care Workers in seleted Health facilities . [Thesis]. University of Zambia; 2017. Available from: http://dspace.unza.zm:8080/xmlui/handle/123456789/4868

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Zambia

7. Nchimba, Lweendo. Prevalence of Hepatitis B and C in Sickle-Cell disease patients at University Teaching Hospital, Lusaka, Zambia .

Degree: 2015, University of Zambia

URL: http://hdl.handle.net/123456789/3726

► Background: Sickle Cell Disease (SCD) is highly prevalent in Africans. The SCD trait is 18% in the general population in Zambia and University Teaching Hospital… (more)

▼ Background: Sickle Cell Disease (SCD) is highly prevalent in Africans. The SCD trait is 18% in the general population in Zambia and University Teaching Hospital in Lusaka has under its care over 1500 SCD patients. SCD causes high morbidity and mortality. Patients with SCD often have pathologies that require a blood transfusion. Specific indications for blood transfusion in SCD include acute splenic sequestration, aplastic crises, cardiopulmonary symptoms or signs (e.g. high-output heart failure or hypoxemia), preoperative use, priapism, and life-threatening events that would benefit from improved oxygen delivery such as sepsis, severe infection, acute chest syndrome, stroke, and acute organ ischemia. In addition, blood transfusion remains the first-line therapy for primary and secondary stroke prevention in children with SCD. Transfusion is usually performed when haemoglobin is less than five g/dL. Both hepatitis B and C are blood-borne and therefore can be transmitted by blood transfusion. SCD patients are a special population that requires frequent blood transfusions. Thus, they are prone to acquiring hepatitis B and C. Screening services have greatly reduced the risk of infection via blood transfusion, but transmissions still occur. Methods: A cross-sectional study was done to determine the prevalence of hepatitis B (HBV) and / or hepatitis C (HCV) infection in the SCD population at UTH in Lusaka. Basic demographic characteristics, medical information and laboratory data were collected and used to determine the predictors for hepatitis B and HCV infections in SCD children and adults. A total of 138 patients were screened for Hepatitis B surface antigen, which is a marker for HBV infection, as well as for hepatitis C antibody, the surrogate marker for HCV infection. Human-immuno-deficiency virus or HIV testing was done on all the samples.Findings: Fifty-nine percent of the participants enrolled were female. The mean age at diagnosis was 2years 9 months ± 2.5. The mean haemoglobin level was 7.2g/dL. Only 37% had confirmation of SCD diagnosis on their medical record. HBV prevalence amongst the SCD is 2.2%. Its prevalence is not associated with blood transfusions, age, tattoos or gender. It has a non-significant association with increasing age and sexual activity. HBV infection has been markedly reduced due to vaccination introduced in 2005 in Zambia. The prevalence of HCV is 0.7% and could not be subjected to much statistical manipulation. Conclusion: HBV prevalence amongst the SCD is 2.2%. Its prevalence was not associated with increase in number of blood transfusions. There was a non-significant association between HBV prevalence and increase in age as well as sexual activity. The prevalence of HCV is 0.7%.

Subjects/Keywords: Sickle-Cell Anemia; Hepatitis B; Hepatitis C

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APA (6^th Edition):

Nchimba, L. (2015). Prevalence of Hepatitis B and C in Sickle-Cell disease patients at University Teaching Hospital, Lusaka, Zambia . (Thesis). University of Zambia. Retrieved from http://hdl.handle.net/123456789/3726

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Nchimba, Lweendo. “Prevalence of Hepatitis B and C in Sickle-Cell disease patients at University Teaching Hospital, Lusaka, Zambia .” 2015. Thesis, University of Zambia. Accessed January 22, 2021. http://hdl.handle.net/123456789/3726.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Nchimba, Lweendo. “Prevalence of Hepatitis B and C in Sickle-Cell disease patients at University Teaching Hospital, Lusaka, Zambia .” 2015. Web. 22 Jan 2021.

Vancouver:

Nchimba L. Prevalence of Hepatitis B and C in Sickle-Cell disease patients at University Teaching Hospital, Lusaka, Zambia . [Internet] [Thesis]. University of Zambia; 2015. [cited 2021 Jan 22]. Available from: http://hdl.handle.net/123456789/3726.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Nchimba L. Prevalence of Hepatitis B and C in Sickle-Cell disease patients at University Teaching Hospital, Lusaka, Zambia . [Thesis]. University of Zambia; 2015. Available from: http://hdl.handle.net/123456789/3726

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

8. Sichone, Victor. Prevalence of hepatitis b virus, HIV and HBV Coinfection and associated factors in pregnant women attending antenatal care at the university teaching hospital, Lusaka, Zambia.

Degree: 2019, University of Zimbabwe

URL: http://dspace.unza.zm/handle/123456789/6362

► Human Immunodeficiency virus (HIV) and Hepatitis B virus (HBV) are a global public health problem which share common risk factors and modes of transmission. Perinatal… (more)

▼ Human Immunodeficiency virus (HIV) and Hepatitis B virus (HBV) are a global public health problem which share common risk factors and modes of transmission. Perinatal transmission is the major route of HBV transmission in endemic areas. Without vaccination, the newborn infant has 10 - 20% risks of developing chronic hepatitis B if the mother is positive for HBsAg, and 90%, if also positive for the HBeAg. The burden of HBV infection in pregnant women at the University Teaching Hospital (UTH) is not known. Hence this study explored the prevalence of HBV infection in HIV positive and HIV negative pregnant women and associated factors. This was a comparative cross-sectional study. A total of 316 pregnant women aged 16-46years were recruited including 158 HIV negative and 158 HIV positive. Recruitment of consenting participants for each subgroup in a 1:1 ratio was done from the antenatal ward until the sample size was attained. A structured questionnaire was administered for socio-demographic data to women with a known HIV status recorded on their antenatal cards. Blood for HBsAg screening were also collected. Data collection was done between 15th Dec 2016 and 30th May, 2017. Of the 316 study participants 11(3.5%) tested positive for HBsAg showing intermediate endemicity. There was no statistical difference in the prevalence of HBV in the HIV negative and HIV positive pregnant women (3.8% and 3.2% respectively, P=0.76. Similarly, there was no association between the age, marital status, parity, residence, religion, education level or form of employment with HBV infection. However, HIV antiretroviral treatment seems to have a protective effect on acquisition of HBV infection [OR = 0.09, CI = 0.01 – 0.63, P = 0.02] Given that no significant differences in the prevalence of HBV in the HIV positive and HIV negative were found, all pregnant women regardless of their HIV status or socio-demographic factors should routinely be screened for Hepatitis B as is recommended by the WHO. Policy makers should make available the Hepatitis B vaccine and Immunoglobulin for infants whose mothers test positive for HBsAg especially those that are also positive for HBeAg. All pregnant women should be counseled on hepatitis B concurrently as the HIV counseling is taking place to increase awareness. All HIV positive women should be encouraged to take antiretroviral drugs as it seems to have a protective effect on the acquisition of HBV infection. A large multi-centre study is, however, necessary to explore this association. Key words: Hepatitis B, Hepatitis C, HIV, Pregnancy

Subjects/Keywords: Hepatitis B; Hepatitis C; HIV – - Pregnancy

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APA (6^th Edition):

Sichone, V. (2019). Prevalence of hepatitis b virus, HIV and HBV Coinfection and associated factors in pregnant women attending antenatal care at the university teaching hospital, Lusaka, Zambia. (Thesis). University of Zimbabwe. Retrieved from http://dspace.unza.zm/handle/123456789/6362

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Sichone, Victor. “Prevalence of hepatitis b virus, HIV and HBV Coinfection and associated factors in pregnant women attending antenatal care at the university teaching hospital, Lusaka, Zambia.” 2019. Thesis, University of Zimbabwe. Accessed January 22, 2021. http://dspace.unza.zm/handle/123456789/6362.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Sichone, Victor. “Prevalence of hepatitis b virus, HIV and HBV Coinfection and associated factors in pregnant women attending antenatal care at the university teaching hospital, Lusaka, Zambia.” 2019. Web. 22 Jan 2021.

Vancouver:

Sichone V. Prevalence of hepatitis b virus, HIV and HBV Coinfection and associated factors in pregnant women attending antenatal care at the university teaching hospital, Lusaka, Zambia. [Internet] [Thesis]. University of Zimbabwe; 2019. [cited 2021 Jan 22]. Available from: http://dspace.unza.zm/handle/123456789/6362.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Sichone V. Prevalence of hepatitis b virus, HIV and HBV Coinfection and associated factors in pregnant women attending antenatal care at the university teaching hospital, Lusaka, Zambia. [Thesis]. University of Zimbabwe; 2019. Available from: http://dspace.unza.zm/handle/123456789/6362

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Johannesburg

9. Caldwell, Sarah. The production of the antibody to the surface antigen of Hepatitis B (anti-HBs) due to Hepatitis B 12cH nosode administration.

Degree: 2014, University of Johannesburg

URL: http://hdl.handle.net/10210/10202

►

M.Tech. (Homoeopathy)

According to the World Health Organisation (2008), an estimated two billion individuals globally, are infected with Hepatitis B (HBV). South Africa reported 864… (more)

▼

M.Tech. (Homoeopathy)

According to the World Health Organisation (2008), an estimated two billion individuals globally, are infected with Hepatitis B (HBV). South Africa reported 864 notified new cases between 2001 and 2004 (Department Of Health, 2005), with an estimated 3-4 million chronic HBV infected black South Africans (Kew, 2008). Kwa-Zulu Natal and Free State were the most affected provinces; while 20-39 years was the most affected age group as of 2005 (Department Of Health, 2005). Workers in the health industry, intravenous drug users and children of women who have Hepatitis B are at the most risk for contracting this disease from blood products and body fluids (Immunization Action Coalition, 2007; Boon et al., 2006), where contraction of the disease can lead to liver cirrhosis, fibrosis and hepato-cellular carcinoma (Highleyman, 2008). The Expanded Program on Immunization (EPI) of the South African Department of Health (2009) suggests vaccination for Hepatitis B should be administered at six, ten and fourteen weeks, or a dose every month for 3 months. Adverse reactions associated with the vaccine include “Guillain-Barre Syndrome, arthritis, demyelinating nervous system disease” (Pratt, 2008) and anaphylaxis (Danis & Halm, 1997). Alternatives that may assist in avoiding such symptoms include: waiting until adolescence to vaccinate (Slonim et al., 2005); only vaccinating high risk groups (Francois et al., 2002); or researching an alternative (Romm, 2001). Homeoprophylaxis is the use of homeopathy to prevent the contraction or development of disease (Zoltan, 2000) and its successful use has been recorded in various disease types and locations. There have been very few studies to show the effect of individual homeopathic nosodes used as prophylactic treatment in their related diseases, with almost none of these utilising any means of serological testing (Bevan-Jones, 2009; Frost et al., 2003; Sheffield, 2006). The aim of this study was to determine the production of the antibody to the surface antigen of Hepatitis B (anti-Hbs) due to Hepatitis B 12cH nosode administration. Forty-three participants ranging, in ages 18 to 65 years, who tested negative for the presence of anti-HBs, took part in this four week long, double-blind, placebo controlled study. Participants were randomly placed into either the Verum or Placebo group, each group receiving four lactose powders to be taken weekly for four weeks. The Active group received lactose powders medicated with Hepatitis B 12cH, whereas the Placebo group received lactose powders medicated with 96% alcohol. Participants underwent a repeat of the serum/plasma antibody testing at the conclusion of the study to determine if there were anti-HBs present in their blood. The results were then statistically analysed using nonparametric testing: Chi-squared independent test, Mann-Whitney test and Sign test. These showed that there was no change measurable effect on the surface antigen of hepatitis B (anti-HBs) of either the Verum (active medication) or Placebo group.…

Subjects/Keywords: Hepatitis B - Prevention; Immunoglobulins; Homeopathy

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APA (6^th Edition):

Caldwell, S. (2014). The production of the antibody to the surface antigen of Hepatitis B (anti-HBs) due to Hepatitis B 12cH nosode administration. (Thesis). University of Johannesburg. Retrieved from http://hdl.handle.net/10210/10202

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Caldwell, Sarah. “The production of the antibody to the surface antigen of Hepatitis B (anti-HBs) due to Hepatitis B 12cH nosode administration.” 2014. Thesis, University of Johannesburg. Accessed January 22, 2021. http://hdl.handle.net/10210/10202.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Caldwell, Sarah. “The production of the antibody to the surface antigen of Hepatitis B (anti-HBs) due to Hepatitis B 12cH nosode administration.” 2014. Web. 22 Jan 2021.

Vancouver:

Caldwell S. The production of the antibody to the surface antigen of Hepatitis B (anti-HBs) due to Hepatitis B 12cH nosode administration. [Internet] [Thesis]. University of Johannesburg; 2014. [cited 2021 Jan 22]. Available from: http://hdl.handle.net/10210/10202.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Caldwell S. The production of the antibody to the surface antigen of Hepatitis B (anti-HBs) due to Hepatitis B 12cH nosode administration. [Thesis]. University of Johannesburg; 2014. Available from: http://hdl.handle.net/10210/10202

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Addis Ababa University

10. Yared, Hailaye. Hepatitis B virus infection among HIV infected individuals with and without antiretroviral therapy in North Shoa Zone, Amhara region, Ethiopia .

Degree: 2012, Addis Ababa University

URL: http://etd.aau.edu.et/dspace/handle/123456789/2921

► Background- The introduction of highly active antiretroviral treatment (HAART) has greatly decreased morbidity and mortality in HIV-infected individuals. In this regard, HBV co infection with… (more)

▼ Background- The introduction of highly active antiretroviral treatment (HAART) has greatly decreased morbidity and mortality in HIV-infected individuals. In this regard, HBV co infection with HIV is becoming a major challenge. Because of shared routes of transmission, 90% of people living with HIV have serological markers of HBV infection and 5-15% of them chronically infected with Hepatitis B Virus. Conditions associated with hepatitis B infection are currently among the leading causes of hospital admission and recent studies have shown increasing rates of liver disease and related death among those with HIV. The impact of co-infection is especially apparent in regions with widespread use of highly active antiretroviral therapy (HAART) where HBV co infection increase hepatotoxicity of HAART and delay immune recovery Objective- To determine the prevalence of hepatitis B virus (HBV) infection among HIV/infected individuals attending care and treatment services in North Shoa zone Methods – A Cohort study was conducted in North Shoa zone from November 2010 to May 2011.HIV infected individuals who were grouped into antiretroviral treatment initiated and Pre- treatment follow up were included in the study. Socio-demographic and clinical data were collected from patient interview, intake form, follow up form and medical record review using structured questionnaire. HBV sero-status was determined by testing presence of Hepatitis B surface antigen using 100ul of serum or plasma detected by SD BIOLINE HBsAg rapid kit confirmed with AxSYM HBsAg(V2) confirmatory test from blood collected for patients follow up. Levels of Alanine transaminase and Aspartate transaminase enzymes and CD4+ count were recorded from laboratory registry and patient follow up forms. Usage of HAART was included to assess if treatment change the natural history of HBV infection. Comparison groups were HBV positive antiretroviral receiving patients and HBV positive antiretroviral Naïve ones. VI Results- The cumulative prevalence of HBsAg in HIV infected individuals was 3.9%.The prevalence was higher in ART initiated than Pre-ART groups, 5.3% and 2.6%, respectively. Despite the difference is not significant. Sex was independently associated with HBsAg prevalence (P=0.03). Males were in increased risk of developing a positive HBsAg test result. (RR=2.32 95%CI: 1.09, 4.96) HBV/HIV co infection was a strong predictor of sharp drop in CD4 cell recovery before starting ART (RR=3.98 95%CI: 1.02,15.48) There was no significant difference observed in the rate of immune recovery and incidence of hepatotoxicity between hepatitis B virus Co-infected and non infected individuals after initiation of ART. Hepatitis B Co-infected individuals isolated were found to be in the chronic Hepatitis B stage with low or moderate Alanine and Aspartate transaminases levels. (41.5IU/L) Conclusion- The prevalence of hepatitis B infection is higher in ART initiated individuals than Pre-ART. Neither HBsAg sero positivity nor a particular ART regimen affect immune recovery in ART… Advisors/Committee Members: Dr. Solomon Gebre-Selassie (MD, MSc,Associate professor) (advisor).

Subjects/Keywords: Hepatitis B virus infection

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APA (6^th Edition):

Yared, H. (2012). Hepatitis B virus infection among HIV infected individuals with and without antiretroviral therapy in North Shoa Zone, Amhara region, Ethiopia . (Thesis). Addis Ababa University. Retrieved from http://etd.aau.edu.et/dspace/handle/123456789/2921

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Yared, Hailaye. “Hepatitis B virus infection among HIV infected individuals with and without antiretroviral therapy in North Shoa Zone, Amhara region, Ethiopia .” 2012. Thesis, Addis Ababa University. Accessed January 22, 2021. http://etd.aau.edu.et/dspace/handle/123456789/2921.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Yared, Hailaye. “Hepatitis B virus infection among HIV infected individuals with and without antiretroviral therapy in North Shoa Zone, Amhara region, Ethiopia .” 2012. Web. 22 Jan 2021.

Vancouver:

Yared H. Hepatitis B virus infection among HIV infected individuals with and without antiretroviral therapy in North Shoa Zone, Amhara region, Ethiopia . [Internet] [Thesis]. Addis Ababa University; 2012. [cited 2021 Jan 22]. Available from: http://etd.aau.edu.et/dspace/handle/123456789/2921.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Yared H. Hepatitis B virus infection among HIV infected individuals with and without antiretroviral therapy in North Shoa Zone, Amhara region, Ethiopia . [Thesis]. Addis Ababa University; 2012. Available from: http://etd.aau.edu.et/dspace/handle/123456789/2921

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Addis Ababa University

11. DANIEL, MEKONNEN. PREVALENCE OF HEPATITIS B VIRUS IN PATIENTS WITH DIABETES MELLITUS: A COMPARATIVE CROSS SECTIONAL STUDY AT WOLDIYA GENERAL HOSPITAL ETHIOPIA .

Degree: 2012, Addis Ababa University

URL: http://etd.aau.edu.et/dspace/handle/123456789/2932

► Background: Hepatitis B Virus (HBV) infection and its sequelae (cirrhosis and liver cancer) are major global health problems. Overall prevalence in Ethiopia varies from 4.7-16.8%… (more)

▼ Background: Hepatitis B Virus (HBV) infection and its sequelae (cirrhosis and liver cancer) are major global health problems. Overall prevalence in Ethiopia varies from 4.7-16.8% for HBsAg and 70-76.4% for at least one marker positive. During recent years evidence has accumulated that in patients with diabetes mellitus, phagocytosis by polymorpho nuclear leukocytes is impaired and disturbances in cell-mediated immune responses can be demonstrated. Cell-mediated immunity is involved in the defense against viruses as well as in that against Mycobacterium and Fungi. However, no increased incidence of viral infections like HBV has yet been reported in patients with diabetes. Objective: To determine the prevalence of HBsAg in patients with diabetes mellitus and to compare those with the non diabetes. It also asses associated factors and liver function tests (LFT); and compare Diabetic and non Diabetic subjects; and HBV positive and negative participants. Methods: The study was a comparative cross sectional study design conducted at Woldiya General Hospital using 108 consented study populations from each study group during the period November, 2010 through January, 2011. A convenience sampling method was used. A total of 216 samples were tested for HBsAg serostatus using VISITECT HBsAg rapid test kit and LFT tests using Humastat 80 chemistry analyzer. Data entered to SPSS-16 and then analyzed using the same soft ware. Multivariate logistic regression was used to see the association of HBV with clinical history of participants and sociodemographic variables. All tests were two-sided with α-level of 0.05 and 80% power. Results: prevalence of HBsAg was equal between diabetes and non diabetes, 3.7% indicating that there was no difference between the two groups. No any Sociodemographic and clinical history of participants were associated with HBV infection (p>0.05) except chronic liver disease. Conclusion: In this study a positive relation was not indicated between HBV and Diabetes and DM in the study area did not predisposed to HBV infection than the rest of the population. Advisors/Committee Members: Dr Solomon Gebre-Selassie (MD, M.Sc) (advisor).

Subjects/Keywords: hepatitis B virus; prevalence,association

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

DANIEL, M. (2012). PREVALENCE OF HEPATITIS B VIRUS IN PATIENTS WITH DIABETES MELLITUS: A COMPARATIVE CROSS SECTIONAL STUDY AT WOLDIYA GENERAL HOSPITAL ETHIOPIA . (Thesis). Addis Ababa University. Retrieved from http://etd.aau.edu.et/dspace/handle/123456789/2932

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

DANIEL, MEKONNEN. “PREVALENCE OF HEPATITIS B VIRUS IN PATIENTS WITH DIABETES MELLITUS: A COMPARATIVE CROSS SECTIONAL STUDY AT WOLDIYA GENERAL HOSPITAL ETHIOPIA .” 2012. Thesis, Addis Ababa University. Accessed January 22, 2021. http://etd.aau.edu.et/dspace/handle/123456789/2932.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

DANIEL, MEKONNEN. “PREVALENCE OF HEPATITIS B VIRUS IN PATIENTS WITH DIABETES MELLITUS: A COMPARATIVE CROSS SECTIONAL STUDY AT WOLDIYA GENERAL HOSPITAL ETHIOPIA .” 2012. Web. 22 Jan 2021.

Vancouver:

DANIEL M. PREVALENCE OF HEPATITIS B VIRUS IN PATIENTS WITH DIABETES MELLITUS: A COMPARATIVE CROSS SECTIONAL STUDY AT WOLDIYA GENERAL HOSPITAL ETHIOPIA . [Internet] [Thesis]. Addis Ababa University; 2012. [cited 2021 Jan 22]. Available from: http://etd.aau.edu.et/dspace/handle/123456789/2932.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

DANIEL M. PREVALENCE OF HEPATITIS B VIRUS IN PATIENTS WITH DIABETES MELLITUS: A COMPARATIVE CROSS SECTIONAL STUDY AT WOLDIYA GENERAL HOSPITAL ETHIOPIA . [Thesis]. Addis Ababa University; 2012. Available from: http://etd.aau.edu.et/dspace/handle/123456789/2932

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Debrecen

12. Kontér, Anita. A krónikus B vírus Hepatitis epidemiológiája,diagnosztikája és kezelése .

Degree: DE – Népegészségügyi Kar, University of Debrecen

URL: http://hdl.handle.net/2437/253021

► Diplomamunkámban bemutatom a krónikus Hepatitis B vírusfertőzés diagnosztizálására alkalmas módszereket, gyógyszeres terápiáját, prevenciójának fontosságát illetve a globális epidemiológiai viszonyokat. Továbbá felhívom a figyelmet a védőoltás… (more)

Subjects/Keywords: Hepatitis B

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APA (6^th Edition):

Kontér, A. (n.d.). A krónikus B vírus Hepatitis epidemiológiája,diagnosztikája és kezelése . (Thesis). University of Debrecen. Retrieved from http://hdl.handle.net/2437/253021

Note: this citation may be lacking information needed for this citation format:
No year of publication.
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Kontér, Anita. “A krónikus B vírus Hepatitis epidemiológiája,diagnosztikája és kezelése .” Thesis, University of Debrecen. Accessed January 22, 2021. http://hdl.handle.net/2437/253021.

Note: this citation may be lacking information needed for this citation format:
No year of publication.
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Kontér, Anita. “A krónikus B vírus Hepatitis epidemiológiája,diagnosztikája és kezelése .” Web. 22 Jan 2021.

Note: this citation may be lacking information needed for this citation format:
No year of publication.

Vancouver:

Kontér A. A krónikus B vírus Hepatitis epidemiológiája,diagnosztikája és kezelése . [Internet] [Thesis]. University of Debrecen; [cited 2021 Jan 22]. Available from: http://hdl.handle.net/2437/253021.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
No year of publication.

Council of Science Editors:

Kontér A. A krónikus B vírus Hepatitis epidemiológiája,diagnosztikája és kezelése . [Thesis]. University of Debrecen; Available from: http://hdl.handle.net/2437/253021

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
No year of publication.

Queen Mary, University of London

13. Dias, Aruna. Chronic hepatitis B infection in the immigrant communities of East London.

Degree: Thesis (M.D.), 2014, Queen Mary, University of London

URL: http://qmro.qmul.ac.uk/xmlui/handle/123456789/8963 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.667311

► Worldwide there are 350 million people with chronic hepatitis B infection and globally it causes up to half of the liver cancer deaths and one… (more)

Subjects/Keywords: 616.3; Medicine; Hepatitis B

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APA (6^th Edition):

Dias, A. (2014). Chronic hepatitis B infection in the immigrant communities of East London. (Doctoral Dissertation). Queen Mary, University of London. Retrieved from http://qmro.qmul.ac.uk/xmlui/handle/123456789/8963 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.667311

Chicago Manual of Style (16^th Edition):

Dias, Aruna. “Chronic hepatitis B infection in the immigrant communities of East London.” 2014. Doctoral Dissertation, Queen Mary, University of London. Accessed January 22, 2021. http://qmro.qmul.ac.uk/xmlui/handle/123456789/8963 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.667311.

MLA Handbook (7^th Edition):

Dias, Aruna. “Chronic hepatitis B infection in the immigrant communities of East London.” 2014. Web. 22 Jan 2021.

Vancouver:

Dias A. Chronic hepatitis B infection in the immigrant communities of East London. [Internet] [Doctoral dissertation]. Queen Mary, University of London; 2014. [cited 2021 Jan 22]. Available from: http://qmro.qmul.ac.uk/xmlui/handle/123456789/8963 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.667311.

Council of Science Editors:

Dias A. Chronic hepatitis B infection in the immigrant communities of East London. [Doctoral Dissertation]. Queen Mary, University of London; 2014. Available from: http://qmro.qmul.ac.uk/xmlui/handle/123456789/8963 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.667311

14. Flink, Hajo. Pegylated Interferon Alfa in HBeAg-positive Chronic Hepatitis B.

Degree: Department of Gastroenterology & Hepatology, 2006, Erasmus University Medical Center

URL: http://hdl.handle.net/1765/8141

► textabstractWord-wide, infection with the hepatitis B virus (HBV) is a major health problem. Over 2 billion people have been exposed to HBV, and approximately 400… (more)

▼ textabstractWord-wide, infection with the hepatitis B virus (HBV) is a major health problem. Over 2 billion people have been exposed to HBV, and approximately 400 million are chronic carriers of the virus. Chronic hepatitis B (CHB) infection may lead in term to liver cirrhosis, hepatic decompensation and hepatocellular carcinoma (HCC), and is responsible for an estimated 1 million deaths annually. The efficacy of the established treatment for CHB is limited.Treatment with conventional interferon (IFN) is only effective in 20-35%. Lamivudine needs to be given long-term to maintain response and leads to emergence of viral resistant strains. Several studies have investigated different treatment options such as peginterferon, adefovir and entecavir.The first randomized controlled trial in HBeAg-positive CHB with peginterferon - which had proven to be more effective than conventional IFN in chronic hepatitis C patients demonstrated that a 52-week course of peginterferon alfa-2b leads to HBeAg seroconversion in 36%, ALT normalization in 35% and HBV DNA < 2.0 x 105 copies/mL in 32% of patients at the end of post treatment follow-up.The addition of lamivudine did not enhance response rates compared to peginterferon alfa-2b alone.The use of conventional IFN is not suited for all patients due to the significant side effects and early treatment discontinuation that may occur.Although the safety profile of peginterferon has been studied in chronic hepatitis C, the side effects of peginterferon in CHB patients have not previously been investigated. We assessed the safety of peginterferon treatment in 266 HBeAg-positive patients who received peginterferon alfa-2b alone or in combination with lamivudine (chapter 2). The most common side effects were similar to those reported for conventional IFN. Flu-like symptoms, headache, fatigue, myalgia, local reaction at the injection, abdominal discomfort and psychiatric symptoms were most frequently reported, but in general subsided during the course of therapy. Hematologic abnormalities (leucopenia, neutropenia and thrombocytopenia) were frequent but did not lead to serious infections or bleeding complications. Neutropenia was the major cause for dose reductions of peginterferon, whereas psychiatric symptoms (depression, psychosis) were the most important reasons for early treatment discontinuation. Pre-existing cirrhosis at baseline was an important risk factor for thrombocytopenia and (minor) bleeding complications.

Subjects/Keywords: hepatitis B

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Flink, H. (2006). Pegylated Interferon Alfa in HBeAg-positive Chronic Hepatitis B. (Doctoral Dissertation). Erasmus University Medical Center. Retrieved from http://hdl.handle.net/1765/8141

Chicago Manual of Style (16^th Edition):

Flink, Hajo. “Pegylated Interferon Alfa in HBeAg-positive Chronic Hepatitis B.” 2006. Doctoral Dissertation, Erasmus University Medical Center. Accessed January 22, 2021. http://hdl.handle.net/1765/8141.

MLA Handbook (7^th Edition):

Flink, Hajo. “Pegylated Interferon Alfa in HBeAg-positive Chronic Hepatitis B.” 2006. Web. 22 Jan 2021.

Vancouver:

Flink H. Pegylated Interferon Alfa in HBeAg-positive Chronic Hepatitis B. [Internet] [Doctoral dissertation]. Erasmus University Medical Center; 2006. [cited 2021 Jan 22]. Available from: http://hdl.handle.net/1765/8141.

Council of Science Editors:

Flink H. Pegylated Interferon Alfa in HBeAg-positive Chronic Hepatitis B. [Doctoral Dissertation]. Erasmus University Medical Center; 2006. Available from: http://hdl.handle.net/1765/8141

15. Stanković, Ana. SPREMLJANJE GIBANJA HEPATITISA B V SLOVENIJI V DESETLETNEM OBDOBJU.

Degree: 2015, Univerza v Mariboru

URL: https://dk.um.si/IzpisGradiva.php?id=46751 ; https://dk.um.si/Dokument.php?id=69543&dn= ; https://plus.si.cobiss.net/opac7/bib/2064804?lang=sl

►

V magistrskem delu smo predstavili virus hepatitisa B, opisali njegove poti prenosa, simptome, diagnostiko ter zdravljenje. Opisali smo cepljenje proti hepatitisu B ter vlogo medicinske… (more)

▼

V magistrskem delu smo predstavili virus hepatitisa B, opisali njegove poti prenosa, simptome, diagnostiko ter zdravljenje. Opisali smo cepljenje proti hepatitisu B ter vlogo medicinske sestre pri preprečevanju okužbe. Namen magistrskega dela je bil analizirati novejše statistične podatke o spremljanju gibanja hepatitisa B v Sloveniji in po svetu. S pomočjo podatkov Nacionalnega inštituta za javno zdravje Republike Slovenije smo dobljene podatke analizirali in jih primerjali z državami Evropske unije. Raziskovalna metodologija. Magistrsko delo temelji na deskriptivni epidemiološki metodi. Statistično je bila izvedena demografska (prijava bolezni po starostnih skupinah), kronološka (skupen prikaz incidence in mortalitete po letih) in topografska analiza (prijava bolezni po zdravstvenih regijah) primerov hepatitisa B v Sloveniji. Rezultati. V Sloveniji je pogostost hepatitisa B v primerjavi z Evropo nizka, pri čemer je incidenca kroničnega hepatitisa B na 100.000 prebivalcev višja od akutnega hepatitisa B. V Sloveniji bistveno bolj obolevajo moški kot ženske. Akutni hepatitis B se najpogosteje pojavlja v starosti od 25 do 44 let, kronični hepatitis B pa od rojstva do starosti 24 let. Za akutnim hepatitisom B jih je v obdobju desetih let največ zbolelo v mariborski regiji, za kroničnim pa v ljubljanski regiji. Sklep. V Sloveniji je v skladu z Zakonom o nalezljivih boleznih prijava hepatitisa B obvezna, na ta način se tudi ocenjuje razširjenost bolezni. Prav gotovo je število okužb višje, saj nekateri ljudje ne iščejo zdravstvene pomoči ali prijava ni popolna, okužba pa lahko poteka brez zunanjih znakov.

In this master's thesis we presented the virus hepatitis B, described its ways of transmission, its symptoms, diagnosis and treatment. We described the vaccination against hepatitis B and the nurse's role in preventing infections. The purpose of this master's thesis was to analyze resent statistic data about tracing the movement of hepatitis B in Slovenia and around the world. With the data from the National Institute of Public Health of the Republic of Slovenia we could analyze gathered data and compare it to other European countries. Research methodology. The master's thesis is based on the descriptive epidemiologic method. Demographic (registration of the disease in certain age groups), chronological (combined presentation of incidence and mortality by certain ages) and topographic analysis (registration of the disease in our health regions) of hepatitis B cases in Slovenia were statistically carried out. Results. In comparison to other European countries the frequency and occurrence of hepatitis B in Slovenia is low, however the incidence of chronical hepatitis B on 100.000 people is higher than the incidence of acute hepatitis. In Slovenia men get infected more often than women. Acute hepatitis B most frequently affects people between 25 and 44 years of age, but chronical hepatitis B affects people birth to the age of 24. In the period of 10 years most infections with acute hepatitis B were reported in the…

Advisors/Committee Members: Fijan, Sabina.

Subjects/Keywords: hepatitis B; akutni hepatitis B; kronični hepatitis B; nalezljiva bolezen; cepljenje.; hepatitis B; acute hepatitis; chronic hepatitis; contagious disease; vaccination.; info:eu-repo/classification/udc/616.36-002

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APA (6^th Edition):

Stanković, A. (2015). SPREMLJANJE GIBANJA HEPATITISA B V SLOVENIJI V DESETLETNEM OBDOBJU. (Masters Thesis). Univerza v Mariboru. Retrieved from https://dk.um.si/IzpisGradiva.php?id=46751 ; https://dk.um.si/Dokument.php?id=69543&dn= ; https://plus.si.cobiss.net/opac7/bib/2064804?lang=sl

Chicago Manual of Style (16^th Edition):

Stanković, Ana. “SPREMLJANJE GIBANJA HEPATITISA B V SLOVENIJI V DESETLETNEM OBDOBJU.” 2015. Masters Thesis, Univerza v Mariboru. Accessed January 22, 2021. https://dk.um.si/IzpisGradiva.php?id=46751 ; https://dk.um.si/Dokument.php?id=69543&dn= ; https://plus.si.cobiss.net/opac7/bib/2064804?lang=sl.

MLA Handbook (7^th Edition):

Stanković, Ana. “SPREMLJANJE GIBANJA HEPATITISA B V SLOVENIJI V DESETLETNEM OBDOBJU.” 2015. Web. 22 Jan 2021.

Vancouver:

Stanković A. SPREMLJANJE GIBANJA HEPATITISA B V SLOVENIJI V DESETLETNEM OBDOBJU. [Internet] [Masters thesis]. Univerza v Mariboru; 2015. [cited 2021 Jan 22]. Available from: https://dk.um.si/IzpisGradiva.php?id=46751 ; https://dk.um.si/Dokument.php?id=69543&dn= ; https://plus.si.cobiss.net/opac7/bib/2064804?lang=sl.

Council of Science Editors:

Stanković A. SPREMLJANJE GIBANJA HEPATITISA B V SLOVENIJI V DESETLETNEM OBDOBJU. [Masters Thesis]. Univerza v Mariboru; 2015. Available from: https://dk.um.si/IzpisGradiva.php?id=46751 ; https://dk.um.si/Dokument.php?id=69543&dn= ; https://plus.si.cobiss.net/opac7/bib/2064804?lang=sl

University of Zambia

16. Nsokolo, Bright. The correlation between baseline serum hepatitis B surface antigen level and levels of other baseline markers of viral activity in patients with chronic hepatitis B viral infection at the University Teaching Hospital .

Degree: 2015, University of Zambia

URL: http://dspace.unza.zm:8080/xmlui/handle/123456789/4313

► Title: The correlation between baseline serum hepatitis B surface antigen level and levels of other baseline markers of viral activity in chronic hepatitis B viral… (more)

▼ Title: The correlation between baseline serum hepatitis B surface antigen level and levels of other baseline markers of viral activity in chronic hepatitis B viral infection at the University Teaching Hospital. Background: Hepatitis B viral (HBV) infection rate among healthy blood donors in Zambia is about 8%, with about 100 000 patients requiring treatment. Effective monitoring of these patients requires the use of the technically difficult and expensive serum HBV DNA levels. Quantifying serum Hepatitis B surface antigen (HBsAg) which is produced by the covalently closed circular DNA (cccDNA), may be a more reliable, simple, inexpensive and non-invasive way of monitoring patients with chronic hepatitis b (CHB) infection. There is a correlation between reduction in serum HBsAg and in cccDNA and total intrahepatic HBV DNA among patients on treatment. However, it remains inconclusive whether serum HBsAg correlates with serum HBV DNA, which would make it helpful in predicting serum viral load. Objective: To determine whether baseline serum HBsAg quantification correlates with other baseline serum hepatitis B viral markers Methodology: This was a cross sectional study. Patients with hepatitis B infection were recruited under the STEP-HEP Study from blood donors in Lusaka, Zambia, medical wards and out-patient medical clinics at UTH over a 15 month period. We screened 49 Patients (HBeAg positive: n=14, HBeAg negative: n=35) with chronic HBV (HBsAg positive for at least 24 weeks) for other causes of liver disease and those with alternative causes of hepatitis were excluded. Blood testing was performed for baseline ALT, serum viral load, HBeAg status and serum HBsAg level. Patients with HBV DNA >2000IU/ml and ALT above the upper limit of normal (35U/L) who did not have radiological evidence of cirrhosis were included in the study. Serum HBV DNA and HBsAg were logarithmically transformed for analysis. Categorical variables were compared by the Pearson chi-square test or the Fisher exact test as appropriate. The Pearson and Spearman correlation coefficients were tested for parametric and non-parametric variables respectively. Statistical significance was defined as a P value of less than 0.05 Results: There was a significant inverse correlation between baseline HBsAg and serum HBV DNA (r = -0.38, P= 0.02). The correlation between serum HBsAg and ALT was not significant (p= 0.94). There was no significant difference in HBsAg level between HBeAg positive and HBeAg negative patients (p= 0.06). The correlation between serum viral load and ALT was also not significant (p=0.26). There was significantly higher ALT in HBeAg positive than in HBeAg negative patients (p=0.016). The serum viral load was significantly higher in HBeAg positive than in HBeAg negative patients (p=0.0001) Conclusion: The inverse correlation between baseline serum HBsAg level and serum HBV DNA may reflect the inadequacy of serum HBV DNA to represent the level of intrahepatic HBV DNA which correlates with serum HBsAg. However, there was no significant…

Subjects/Keywords: Hepatitis B Virus – Research; Hepatitis B virus – Physiopathology

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APA (6^th Edition):

Nsokolo, B. (2015). The correlation between baseline serum hepatitis B surface antigen level and levels of other baseline markers of viral activity in patients with chronic hepatitis B viral infection at the University Teaching Hospital . (Thesis). University of Zambia. Retrieved from http://dspace.unza.zm:8080/xmlui/handle/123456789/4313

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Nsokolo, Bright. “The correlation between baseline serum hepatitis B surface antigen level and levels of other baseline markers of viral activity in patients with chronic hepatitis B viral infection at the University Teaching Hospital .” 2015. Thesis, University of Zambia. Accessed January 22, 2021. http://dspace.unza.zm:8080/xmlui/handle/123456789/4313.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Nsokolo, Bright. “The correlation between baseline serum hepatitis B surface antigen level and levels of other baseline markers of viral activity in patients with chronic hepatitis B viral infection at the University Teaching Hospital .” 2015. Web. 22 Jan 2021.

Vancouver:

Nsokolo B. The correlation between baseline serum hepatitis B surface antigen level and levels of other baseline markers of viral activity in patients with chronic hepatitis B viral infection at the University Teaching Hospital . [Internet] [Thesis]. University of Zambia; 2015. [cited 2021 Jan 22]. Available from: http://dspace.unza.zm:8080/xmlui/handle/123456789/4313.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Nsokolo B. The correlation between baseline serum hepatitis B surface antigen level and levels of other baseline markers of viral activity in patients with chronic hepatitis B viral infection at the University Teaching Hospital . [Thesis]. University of Zambia; 2015. Available from: http://dspace.unza.zm:8080/xmlui/handle/123456789/4313

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Alberta

17. Zimmerman, Kimberley Anne. Designed zinc finger proteins as novel therapeutics inhibiting the transcription of hepatitis B and duck hepatitis B viruses.

Degree: PhD, Department of Medical Microbiology and Immunology, 2010, University of Alberta

URL: https://era.library.ualberta.ca/files/cr56n098w

► The Hepatitis B virus (HBV) chronically infects 350 million individuals worldwide, leading to mortality by end-stage liver disease, liver cirrhosis, and hepatocellular carcinoma. The vaccine… (more)

▼ The Hepatitis B virus (HBV) chronically infects 350 million individuals worldwide, leading to mortality by end-stage liver disease, liver cirrhosis, and hepatocellular carcinoma. The vaccine to prevent HBV infection is highly effective but is not extensively available in endemic areas, resulting in high infection rates. Nucleoside analogue treatment of HBV has allowed for higher rates of viral clearance in infected individuals, but most patients must remain on therapy long term and viral resistance to the drugs is growing. The HBV viral genome is an episome in the nucleus of infected hepatocytes. It is called covalently closed circular (ccc) DNA and is highly stable, has a long half-life, and is the template for all viral transcription and progeny production. Nucleoside analogues do not directly target cccDNA, therefore many patients experience rebound when antiviral therapy is stopped. I have designed novel DNA binding proteins called zinc finger proteins (ZFPs) to specifically bind to the cccDNA in infected cells and inhibit viral transcription. Seven ZFPs targeting the model duck HBV (DHBV) and ten ZFPs targeting HBV were developed. Kinetic analyses of the purified ZFPs were performed, characterizing their specificity and binding properties. Using the DHBV tissue culture model system, I have demonstrated that the DHBV-specific ZFPs can specifically inhibit transcription from the viral template, resulting in reduced viral RNA, protein products and progeny virions. The DHBV-specific ZFPs were tested in primary duck hepatocytes (PDH) and in vivo in the Pekin duck model. ZFPs failed to express in PDH transduced by baculovirus vectors when DHBV was present in the cells. In vivo gene delivery of the ZFPs was carried out by portal vein injection of chitosan-based nanospheres. Unfortunately, non-specific reductions in viral levels masked any direct effect by the ZFPs. Testing of the HBV-specific ZFPs in tissue culture was hindered by a lack of transfectable cell culture model. A number of different transfection methods were tested to express the HBV-specific ZFPs, all without success. Further work is being carried out using baculovirus vectors to deliver the HBV-specific ZFPs to HBV-harbouring cell lines and HBV-infected scid-Alb/uPA chimeric mice with human liver cells.

Subjects/Keywords: zinc finger protein; duck hepatitis B; inhibition; cccDNA; hepatitis B

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APA (6^th Edition):

Zimmerman, K. A. (2010). Designed zinc finger proteins as novel therapeutics inhibiting the transcription of hepatitis B and duck hepatitis B viruses. (Doctoral Dissertation). University of Alberta. Retrieved from https://era.library.ualberta.ca/files/cr56n098w

Chicago Manual of Style (16^th Edition):

Zimmerman, Kimberley Anne. “Designed zinc finger proteins as novel therapeutics inhibiting the transcription of hepatitis B and duck hepatitis B viruses.” 2010. Doctoral Dissertation, University of Alberta. Accessed January 22, 2021. https://era.library.ualberta.ca/files/cr56n098w.

MLA Handbook (7^th Edition):

Zimmerman, Kimberley Anne. “Designed zinc finger proteins as novel therapeutics inhibiting the transcription of hepatitis B and duck hepatitis B viruses.” 2010. Web. 22 Jan 2021.

Vancouver:

Zimmerman KA. Designed zinc finger proteins as novel therapeutics inhibiting the transcription of hepatitis B and duck hepatitis B viruses. [Internet] [Doctoral dissertation]. University of Alberta; 2010. [cited 2021 Jan 22]. Available from: https://era.library.ualberta.ca/files/cr56n098w.

Council of Science Editors:

Zimmerman KA. Designed zinc finger proteins as novel therapeutics inhibiting the transcription of hepatitis B and duck hepatitis B viruses. [Doctoral Dissertation]. University of Alberta; 2010. Available from: https://era.library.ualberta.ca/files/cr56n098w

University of Adelaide

18. Noordeen, Faseeha. Development of antiviral therapies for chronic hepatitis B virus infection.

Degree: 2010, University of Adelaide

URL: http://hdl.handle.net/2440/62330

► Acute hepatitis B virus (HBV) infection is self-limiting but leaves a residual infection that can become active in an individual under conditions of immunosuppression. In… (more)

▼ Acute hepatitis B virus (HBV) infection is self-limiting but leaves a residual infection that can become active in an individual under conditions of immunosuppression. In chronic HBV infection, the virus persistently replicates in hepatocytes and this leads to immune mediated hepatocyte damage. Chronic HBV infection, which occurs worldwide in more than 400 million people, is associated with liver disease, fibrosis, cirrhosis and hepatocellular carcinoma (HCC) (Hepatitis B Fact Sheet 2009). There is a significant need for treatment intervention in chronic HBV infection. Despite the inability to remove the virus in more than 70% of patients, current treatments for chronic HBV infection, which include interferon alpha (IFN-α) and antiviral nucleotide/nucleoside analogues (NAs), aim to reduce levels of viral replication and to prevent or at least delay the progression of disease and the development of cirrhosis and HCC. Current NA therapy involves monotherapy with a conventional NA as a single antiviral agent (Sasadeusz et al. 2007). In the recent past, poor response to monotherapies with NAs and adverse effects to IFN-α have stimulated research into novel therapeutic strategies and enhancing the efficacy of exsisting NA therapy. The duck HBV (DHBV) in its natural host, the Pekin duck (Anas domesticus platyrhynchos), has been used as an animal model to study treatment outcomes and antiviral studies at the pre-clinical level. Much of what is known about viral replication and outcomes of hepadnavirus infection has been discovered using the DHBV model (Schultz et al. 2004; Zoulim et al. 2008) and several immunotherapeutic and antiviral studies have been performed recently in our laboratory (Foster et al. 2003; Miller et al. 2004; Foster et al. 2005; Miller et al. 2006a; Miller et al. 2006b; Miller et al. 2008). The studies described in this Ph.D. thesis focused on the development and testing of novel therapies for chronic HBV infection using the DHBV model. The first approach involved the use of novel amphipathic DNA polymers (APDPs) developed by REPLICor Inc. The second approach tested a combination of NAs developed by Gilead Sciences Pty. Ltd. APDPs developed by REPLICor Inc. have been used as a novel therapeutic approach against human immunodeficiency virus type 1 (HIV-1) and have been shown to inhibit HIV-1-mediated membrane fusion and HIV-1 replication in a size dependent but sequence independent manner (Vaillant et al. 2006). HIV-1 entry is well characterised and involves fusion of the virus to its target cells using a type 1 fusion protein. APDPs are thought to inhibit HIV-1 infection by acting as fusion inhibitors that bind to the V3 loop of the HIV-1 gp41 domain preventing its interaction with the T cell receptor, CD4. Phosphorothioation of oligonucleotides increases their hydrophobicity (amphipathicity) and also makes them more resistant to degradation by nucleases. The amphipathicity of APDPs plays a major role in their antiviral activity. Longer APDPs with lengths of ≥30 bases have a greater amphipathicity… Advisors/Committee Members: Jilbert, Allison Rae (advisor), Beard, Michael Robert (advisor), School of Molecular and Biomedical Science (school).

Subjects/Keywords: antiviral therapies; hepatitis B; virus; chronic hepatitis B

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Noordeen, F. (2010). Development of antiviral therapies for chronic hepatitis B virus infection. (Thesis). University of Adelaide. Retrieved from http://hdl.handle.net/2440/62330

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Noordeen, Faseeha. “Development of antiviral therapies for chronic hepatitis B virus infection.” 2010. Thesis, University of Adelaide. Accessed January 22, 2021. http://hdl.handle.net/2440/62330.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Noordeen, Faseeha. “Development of antiviral therapies for chronic hepatitis B virus infection.” 2010. Web. 22 Jan 2021.

Vancouver:

Noordeen F. Development of antiviral therapies for chronic hepatitis B virus infection. [Internet] [Thesis]. University of Adelaide; 2010. [cited 2021 Jan 22]. Available from: http://hdl.handle.net/2440/62330.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Noordeen F. Development of antiviral therapies for chronic hepatitis B virus infection. [Thesis]. University of Adelaide; 2010. Available from: http://hdl.handle.net/2440/62330

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Hong Kong

19. 司徒偉基. Virologic and serologic kinetics in the natural history and treatment of chronic hepatitis B.

Degree: 2012, University of Hong Kong

URL: http://hdl.handle.net/10722/180104

► This thesis investigated how virologic and serologic kinetics of the hepatitis B virus (HBV) could influence the natural history and treatment of chronic hepatitis B… (more)

▼ This thesis investigated how virologic and serologic kinetics of the hepatitis B virus (HBV) could influence the natural history and treatment of chronic hepatitis B (CHB). Virologic kinetics were described in the first five studies, with serologic kinetics being described in the next five. The first study delineated the HBV DNA profiles of 1,400 treatment-naive Asian CHB patients. Increasing viremia was noted with increasing age, highlighting the large therapeutic demand in Asian patients with hepatitis B e antigen (HBeAg)-negative CHB. The second study analyzed the association between viral load and liver histology in 319 patients, showing HBV DNA levels to have strong association with HBeAg-negative disease severity. The next three studies investigated the efficacy of baseline and on-treatment HBV DNA levels in predicting clinical outcomes in 117, 165 and 222 patients on telbivudine, lamivudine plus adefovir and entecavir respectively. Absolute on-treatment HBV DNA levels at week 12 or 24 predicted favorable outcome with telbivudine and lamivudine / adefovir therapy, while excellent viremic suppression with very low rate of resistance development was shown in the entecavir study. The following three studies examined the role of serum HBsAg measurements in different disease phases of CHB. First, histology specimens of 140 HBeAg-positive patients were analyzed together with HBsAg levels. High HBsAg titers (>25,000 IU/mL) were found to be predictive of insignificant fibrosis. In the next study involving 300 treatment-naive HBeAg-negative patients stratified by their viral loads, combination of low HBsAg and HBV DNA levels predicted significant HBsAg decline. This is followed by a study comparing HBsAg levels of 203 CHB patients achieving HBsAg seroclearance with 203 age- and sex-matched controls over a 3-year period. Serum HBsAg <200 IU/mL and a significant annual HBsAg reduction were found to be predictive of HBsAg seroclearance. The penultimate study investigated the usage of two novel HBV serologic markers, linearized HBsAg and hepatitis B core-related antigen, in 329 CHB patients achieving HBsAg seroclearance with a conventional HBsAg assay. More than 40% of patients had seropositivity to one or both serologic tests. Finally, the last study of this thesis investigated and compared the changes in serum HBsAg, intrahepatic HBV DNA and covalently closed circular DNA (cccDNA) after 1 year of nucleoside analogue therapy. Minimal changes in both serum HBsAg and intrahepatic cccDNA were noted after 1 year of therapy, but in patients with a significant decline in serum HBsAg levels, there was a corresponding significant reduction in cccDNA. This series of studies illustrated how the monitoring of serum HBV DNA and HBsAg levels could assist in optimizing management strategies for CHB.

Subjects/Keywords: Hepatitis B.; Hepatitis B virus.

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

司徒偉基.. (2012). Virologic and serologic kinetics in the natural history and treatment of chronic hepatitis B. (Thesis). University of Hong Kong. Retrieved from http://hdl.handle.net/10722/180104

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

司徒偉基.. “Virologic and serologic kinetics in the natural history and treatment of chronic hepatitis B.” 2012. Thesis, University of Hong Kong. Accessed January 22, 2021. http://hdl.handle.net/10722/180104.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

司徒偉基.. “Virologic and serologic kinetics in the natural history and treatment of chronic hepatitis B.” 2012. Web. 22 Jan 2021.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete

Vancouver:

司徒偉基.. Virologic and serologic kinetics in the natural history and treatment of chronic hepatitis B. [Internet] [Thesis]. University of Hong Kong; 2012. [cited 2021 Jan 22]. Available from: http://hdl.handle.net/10722/180104.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

司徒偉基.. Virologic and serologic kinetics in the natural history and treatment of chronic hepatitis B. [Thesis]. University of Hong Kong; 2012. Available from: http://hdl.handle.net/10722/180104

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation

20. Goma, Jane. Seroprevalence of hepatitis b infection in children less than five years of age at the university teaching hospitals - children’s hospital and Kamwala Health Centre in the vaccination era in Lusaka, Zambia.

Degree: 2019, University of Zimbabwe

URL: http://dspace.unza.zm/handle/123456789/6394

► HBV infection is a serious infection affecting the liver and causes significant morbidity and mortality in sub-Sahara Africa. While most patients with chronic hepatitis B… (more)

Subjects/Keywords: Hepatitis B vaccine; Hepatitis B vaccine – Children – Zambia

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APA (6^th Edition):

Goma, J. (2019). Seroprevalence of hepatitis b infection in children less than five years of age at the university teaching hospitals - children’s hospital and Kamwala Health Centre in the vaccination era in Lusaka, Zambia. (Thesis). University of Zimbabwe. Retrieved from http://dspace.unza.zm/handle/123456789/6394

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Goma, Jane. “Seroprevalence of hepatitis b infection in children less than five years of age at the university teaching hospitals - children’s hospital and Kamwala Health Centre in the vaccination era in Lusaka, Zambia.” 2019. Thesis, University of Zimbabwe. Accessed January 22, 2021. http://dspace.unza.zm/handle/123456789/6394.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Goma, Jane. “Seroprevalence of hepatitis b infection in children less than five years of age at the university teaching hospitals - children’s hospital and Kamwala Health Centre in the vaccination era in Lusaka, Zambia.” 2019. Web. 22 Jan 2021.

Vancouver:

Goma J. Seroprevalence of hepatitis b infection in children less than five years of age at the university teaching hospitals - children’s hospital and Kamwala Health Centre in the vaccination era in Lusaka, Zambia. [Internet] [Thesis]. University of Zimbabwe; 2019. [cited 2021 Jan 22]. Available from: http://dspace.unza.zm/handle/123456789/6394.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Goma J. Seroprevalence of hepatitis b infection in children less than five years of age at the university teaching hospitals - children’s hospital and Kamwala Health Centre in the vaccination era in Lusaka, Zambia. [Thesis]. University of Zimbabwe; 2019. Available from: http://dspace.unza.zm/handle/123456789/6394

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

21. Dakić Zoran. Značaj primene definicije slučaja za unapređenje epidemiološkog nadzora nad hepatitisima B i C.

Degree: 2017, University of Novi Sad

URL: https://www.cris.uns.ac.rs/DownloadFileServlet/Disertacija145923723116719.pdf?controlNumber=(BISIS)100362&fileName=145923723116719.pdf&id=5188&source=OATD&language=en ; https://www.cris.uns.ac.rs/record.jsf?recordId=100362&source=OATD&language=en

►

Adekvatni nadzor nad zaraznim bolestima predstavlja aktuelni izazov ne samo kod nas već i u razvijenim zemljama. Savremeni epidemiološki nadzor nad zaraznim bolestima zasniva… (more)

▼

Adekvatni nadzor nad zaraznim bolestima predstavlja aktuelni izazov ne samo kod nas već i u razvijenim zemljama. Savremeni epidemiološki nadzor nad zaraznim bolestima zasniva se na odgovarajućim definicijama slučaja. Njihova osnovna funkcija je olakšavanje prepoznavanja određenih bolesti i njihovo registrovanje na jednoobrazan način. Definisanje slučajeva zaraznih bolesti nije jednostavno, jer uključuje kliničke, epidemiološke i laboratorijske parametre, uz istovremeno očekivanje visoke senzitivnosti i specifičnosti. Ciljevi istraživanja su bili da se utvrdi primenljivost definicija slučaja hepatitisa B i C na Klinici za infektivne bolesti Kliničkog centra Vojvodine, te da se utvrdi senzitivnost i specifičnost primenjenih definicija slučaja hepatitisa B i C. Uz postojeći dijagnostički algoritam Klinike za infektivne bolesti Kliničkog centra Vojvodine, uvedena su tri seta definicija hepatitisa B i C: Evropskog centra za prevenciju i kontrolu bolesti (ECDC) iz 2008. i 2012.godine kao i američkih Centara za kontrolu bolesti (CDC) iz 2012. godine. Istraživanje je sprovedeno na Klinici za infektivne bolesti Kliničkog centra Vojvodine i tokom 12 meseci, u skladu sa predloženim definicijama slučaja, identifikovano je 150 ispitanika obolelih od hepatitisa B i C. Utvrđene su sledeće činjenice: preporučene definicije slučaja su primenljive u Republici Srbiji za laboratorijske i kliničke kriterijume, dok uključivanje epidemiološke povezanosti u definicije slučaja ima malo praktičnog značaja za prijavljivanje hepatitisa; definicije slučaja koje uključuju i obavezno prisustvo kliničkih kriterijuma (najčešće definicije verovatnog slučaja) imaju nisku senzitivnost, a visoku specifičnost, kao posledica prisustva infekcije i u odsustvu bilo kakvih kliničkih manifestacija; definicije slučaja koje se zasnivaju samo na laboratorijskim kriterijumima imaju maksimalnu senzitivnost i specifičnost.

Adequate surveillance of communicable diseases is the actual challenge, not only in our country but also in developed countries. Modern epidemiological surveillance of communicable diseases is based on the appropriate case definitions. Their main purpose of them is to facilitate the recognition of certain diseases and their registration in a uniform manner. Case definition of communicable diseases is not easy, because it involves clinical, epidemiological and laboratory parameters, along with the expectated high sensitivity and specificity.The objectives of the study were to determine the applicability of the casedefinitions for hepatitis B and C in the Clinic for Infectious Diseases of the Clinical Center of Vojvodina and to determine the sensitivity and specificity of the applied definition of cases of hepatitis B and C. In addition to existing diagnostic algorithm of the Clinic for Infectious Diseases, three sets of hepatitis B and C case definitions were introduced: the European Centre for Disease Prevention and Control in 2008 and 2012 as well as the US Centers for Disease Control in 2012. The…

Advisors/Committee Members: Đurić Predrag, Fabri Milotka, Dragovac Gorana, Kocić Biljana, Turkulov Vesna, Dugandžija Tihomir, Petrović Vladimir.

Subjects/Keywords: hepatitis B; hepatitis C; dijagnoza; epidemiologija; javno zdravlje; Hepatitis B; Hepatitis C; Diagnosis; Epidemiology; Public Health

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Zoran, D. (2017). Značaj primene definicije slučaja za unapređenje epidemiološkog nadzora nad hepatitisima B i C. (Thesis). University of Novi Sad. Retrieved from https://www.cris.uns.ac.rs/DownloadFileServlet/Disertacija145923723116719.pdf?controlNumber=(BISIS)100362&fileName=145923723116719.pdf&id=5188&source=OATD&language=en ; https://www.cris.uns.ac.rs/record.jsf?recordId=100362&source=OATD&language=en

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Zoran, Dakić. “Značaj primene definicije slučaja za unapređenje epidemiološkog nadzora nad hepatitisima B i C.” 2017. Thesis, University of Novi Sad. Accessed January 22, 2021. https://www.cris.uns.ac.rs/DownloadFileServlet/Disertacija145923723116719.pdf?controlNumber=(BISIS)100362&fileName=145923723116719.pdf&id=5188&source=OATD&language=en ; https://www.cris.uns.ac.rs/record.jsf?recordId=100362&source=OATD&language=en.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Zoran, Dakić. “Značaj primene definicije slučaja za unapređenje epidemiološkog nadzora nad hepatitisima B i C.” 2017. Web. 22 Jan 2021.

Vancouver:

Zoran D. Značaj primene definicije slučaja za unapređenje epidemiološkog nadzora nad hepatitisima B i C. [Internet] [Thesis]. University of Novi Sad; 2017. [cited 2021 Jan 22]. Available from: https://www.cris.uns.ac.rs/DownloadFileServlet/Disertacija145923723116719.pdf?controlNumber=(BISIS)100362&fileName=145923723116719.pdf&id=5188&source=OATD&language=en ; https://www.cris.uns.ac.rs/record.jsf?recordId=100362&source=OATD&language=en.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Zoran D. Značaj primene definicije slučaja za unapređenje epidemiološkog nadzora nad hepatitisima B i C. [Thesis]. University of Novi Sad; 2017. Available from: https://www.cris.uns.ac.rs/DownloadFileServlet/Disertacija145923723116719.pdf?controlNumber=(BISIS)100362&fileName=145923723116719.pdf&id=5188&source=OATD&language=en ; https://www.cris.uns.ac.rs/record.jsf?recordId=100362&source=OATD&language=en

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

22. 長岡, 進矢. Hepatic flares promote rapid decline of serum hepatitis B surface antigen (HBsAg) in patients with HBsAg seroclearance: A long-term follow-up study : B型肝炎長期観察例におけるHBsAg陰性化までのHBsAgの減衰と肝機能上昇との関連.

Degree: 博士(医学), 2016, Nagasaki University / 長崎大学

URL: http://hdl.handle.net/10069/36232

► Aim: Serum hepatitis B surface antigen (HBsAg) seroclearance is one of the ultimate goals of management of chronic hepatitis B. We investigated the kinetics of… (more)

Subjects/Keywords: alanine aminotransferase flare; chronic hepatitis B; hepatitis B surface antigen seroclearance; hepatitis B surface antigen quantification

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APA (6^th Edition):

長岡, �. (2016). Hepatic flares promote rapid decline of serum hepatitis B surface antigen (HBsAg) in patients with HBsAg seroclearance: A long-term follow-up study : B型肝炎長期観察例におけるHBsAg陰性化までのHBsAgの減衰と肝機能上昇との関連. (Thesis). Nagasaki University / 長崎大学. Retrieved from http://hdl.handle.net/10069/36232

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

長岡, 進矢. “Hepatic flares promote rapid decline of serum hepatitis B surface antigen (HBsAg) in patients with HBsAg seroclearance: A long-term follow-up study : B型肝炎長期観察例におけるHBsAg陰性化までのHBsAgの減衰と肝機能上昇との関連.” 2016. Thesis, Nagasaki University / 長崎大学. Accessed January 22, 2021. http://hdl.handle.net/10069/36232.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

長岡, 進矢. “Hepatic flares promote rapid decline of serum hepatitis B surface antigen (HBsAg) in patients with HBsAg seroclearance: A long-term follow-up study : B型肝炎長期観察例におけるHBsAg陰性化までのHBsAgの減衰と肝機能上昇との関連.” 2016. Web. 22 Jan 2021.

Vancouver:

長岡 �. Hepatic flares promote rapid decline of serum hepatitis B surface antigen (HBsAg) in patients with HBsAg seroclearance: A long-term follow-up study : B型肝炎長期観察例におけるHBsAg陰性化までのHBsAgの減衰と肝機能上昇との関連. [Internet] [Thesis]. Nagasaki University / 長崎大学; 2016. [cited 2021 Jan 22]. Available from: http://hdl.handle.net/10069/36232.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

長岡 �. Hepatic flares promote rapid decline of serum hepatitis B surface antigen (HBsAg) in patients with HBsAg seroclearance: A long-term follow-up study : B型肝炎長期観察例におけるHBsAg陰性化までのHBsAgの減衰と肝機能上昇との関連. [Thesis]. Nagasaki University / 長崎大学; 2016. Available from: http://hdl.handle.net/10069/36232

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

23. Buster, Erik. Chronic Hepatitis B: Individualized Antiviral Therapy.

Degree: 2009, Erasmus University Medical Center

URL: http://hdl.handle.net/1765/17114

► textabstractThe hepatitis B virus (HBV) was discovered in 1966 with the identification of the Australia antigen in Aboriginals by Dr. Baruch Blumberg, who received the… (more)

Subjects/Keywords: Acute Hepatitis B; Chronic Hepatitis B; Hepatitis B

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APA (6^th Edition):

Buster, E. (2009). Chronic Hepatitis B: Individualized Antiviral Therapy. (Doctoral Dissertation). Erasmus University Medical Center. Retrieved from http://hdl.handle.net/1765/17114

Chicago Manual of Style (16^th Edition):

Buster, Erik. “Chronic Hepatitis B: Individualized Antiviral Therapy.” 2009. Doctoral Dissertation, Erasmus University Medical Center. Accessed January 22, 2021. http://hdl.handle.net/1765/17114.

MLA Handbook (7^th Edition):

Buster, Erik. “Chronic Hepatitis B: Individualized Antiviral Therapy.” 2009. Web. 22 Jan 2021.

Vancouver:

Buster E. Chronic Hepatitis B: Individualized Antiviral Therapy. [Internet] [Doctoral dissertation]. Erasmus University Medical Center; 2009. [cited 2021 Jan 22]. Available from: http://hdl.handle.net/1765/17114.

Council of Science Editors:

Buster E. Chronic Hepatitis B: Individualized Antiviral Therapy. [Doctoral Dissertation]. Erasmus University Medical Center; 2009. Available from: http://hdl.handle.net/1765/17114

Dalhousie University

24. Dawson, Paul WH. Hepatitis B Virus X Protein Induces Cellular Senescence and Autophagy.

Degree: MS, Department of Microbiology & Immunology, 2011, Dalhousie University

URL: http://hdl.handle.net/10222/14156

► Hepatitis B virus (HBV) is a significant global threat to human health due to its ability to cause chronic infections that can lead to hepatocellular… (more)

Subjects/Keywords: Hepatitis B; Autophagy; Cellular Senescence; HBx

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APA (6^th Edition):

Dawson, P. W. (2011). Hepatitis B Virus X Protein Induces Cellular Senescence and Autophagy. (Masters Thesis). Dalhousie University. Retrieved from http://hdl.handle.net/10222/14156

Chicago Manual of Style (16^th Edition):

Dawson, Paul WH. “Hepatitis B Virus X Protein Induces Cellular Senescence and Autophagy.” 2011. Masters Thesis, Dalhousie University. Accessed January 22, 2021. http://hdl.handle.net/10222/14156.

MLA Handbook (7^th Edition):

Dawson, Paul WH. “Hepatitis B Virus X Protein Induces Cellular Senescence and Autophagy.” 2011. Web. 22 Jan 2021.

Vancouver:

Dawson PW. Hepatitis B Virus X Protein Induces Cellular Senescence and Autophagy. [Internet] [Masters thesis]. Dalhousie University; 2011. [cited 2021 Jan 22]. Available from: http://hdl.handle.net/10222/14156.

Council of Science Editors:

Dawson PW. Hepatitis B Virus X Protein Induces Cellular Senescence and Autophagy. [Masters Thesis]. Dalhousie University; 2011. Available from: http://hdl.handle.net/10222/14156

25. Li, Yuan. LUC7L3/CROP inhibits replication of hepatitis B virus via suppressing enhancer II/basal core promoter activity : LUC7L3/CROPはエンハンサーII/ベーサルコアプロモーターを抑制することによりB型肝炎ウイルスの複製を阻害する.

Degree: 博士（医学）, 2017, Hamamatsu University School of Medicine / 浜松医科大学

URL: http://hdl.handle.net/10271/3215

►

The core promoter of hepatitis B virus (HBV) genome is a critical region for transcriptional initiation of 3.5 kb, pregenome and precore RNAs and for… (more)

Subjects/Keywords: Hepatitis B virus; HBV; replication; promoter; enhancer

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APA (6^th Edition):

Li, Y. (2017). LUC7L3/CROP inhibits replication of hepatitis B virus via suppressing enhancer II/basal core promoter activity : LUC7L3/CROPはエンハンサーII/ベーサルコアプロモーターを抑制することによりB型肝炎ウイルスの複製を阻害する. (Thesis). Hamamatsu University School of Medicine / 浜松医科大学. Retrieved from http://hdl.handle.net/10271/3215

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Li, Yuan. “LUC7L3/CROP inhibits replication of hepatitis B virus via suppressing enhancer II/basal core promoter activity : LUC7L3/CROPはエンハンサーII/ベーサルコアプロモーターを抑制することによりB型肝炎ウイルスの複製を阻害する.” 2017. Thesis, Hamamatsu University School of Medicine / 浜松医科大学. Accessed January 22, 2021. http://hdl.handle.net/10271/3215.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Li, Yuan. “LUC7L3/CROP inhibits replication of hepatitis B virus via suppressing enhancer II/basal core promoter activity : LUC7L3/CROPはエンハンサーII/ベーサルコアプロモーターを抑制することによりB型肝炎ウイルスの複製を阻害する.” 2017. Web. 22 Jan 2021.

Vancouver:

Li Y. LUC7L3/CROP inhibits replication of hepatitis B virus via suppressing enhancer II/basal core promoter activity : LUC7L3/CROPはエンハンサーII/ベーサルコアプロモーターを抑制することによりB型肝炎ウイルスの複製を阻害する. [Internet] [Thesis]. Hamamatsu University School of Medicine / 浜松医科大学; 2017. [cited 2021 Jan 22]. Available from: http://hdl.handle.net/10271/3215.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Li Y. LUC7L3/CROP inhibits replication of hepatitis B virus via suppressing enhancer II/basal core promoter activity : LUC7L3/CROPはエンハンサーII/ベーサルコアプロモーターを抑制することによりB型肝炎ウイルスの複製を阻害する. [Thesis]. Hamamatsu University School of Medicine / 浜松医科大学; 2017. Available from: http://hdl.handle.net/10271/3215

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Hong Kong

26. Yang, Zhenyu. Epidemiological survey of hepatitis B in the Guangzhou development zone from 2004 to 2008.

Degree: 2009, University of Hong Kong

URL: http://hdl.handle.net/10722/56906

Subjects/Keywords: Hepatitis B - Epidemiology

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Yang, Z. (2009). Epidemiological survey of hepatitis B in the Guangzhou development zone from 2004 to 2008. (Thesis). University of Hong Kong. Retrieved from http://hdl.handle.net/10722/56906

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Yang, Zhenyu. “Epidemiological survey of hepatitis B in the Guangzhou development zone from 2004 to 2008.” 2009. Thesis, University of Hong Kong. Accessed January 22, 2021. http://hdl.handle.net/10722/56906.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Yang, Zhenyu. “Epidemiological survey of hepatitis B in the Guangzhou development zone from 2004 to 2008.” 2009. Web. 22 Jan 2021.

Vancouver:

Yang Z. Epidemiological survey of hepatitis B in the Guangzhou development zone from 2004 to 2008. [Internet] [Thesis]. University of Hong Kong; 2009. [cited 2021 Jan 22]. Available from: http://hdl.handle.net/10722/56906.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Yang Z. Epidemiological survey of hepatitis B in the Guangzhou development zone from 2004 to 2008. [Thesis]. University of Hong Kong; 2009. Available from: http://hdl.handle.net/10722/56906

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Drexel University

27. Kim, John. Quantification of Hepatitis B Surface Antigen (HBsAg) in a Haimen City, China Cohort.

Degree: 2012, Drexel University

URL: http://hdl.handle.net/1860/3953

►

Background: Liver cancer is the fifth most frequently diagnosed cancer, with hepatocellular carcinoma (HCC) constituting the majority of cases. Chronic hepatitis B (CHB) can incur… (more)

Subjects/Keywords: Public Health; Hepatitis B; China; Hepatocellular Carcinoma

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APA (6^th Edition):

Kim, J. (2012). Quantification of Hepatitis B Surface Antigen (HBsAg) in a Haimen City, China Cohort. (Thesis). Drexel University. Retrieved from http://hdl.handle.net/1860/3953

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Kim, John. “Quantification of Hepatitis B Surface Antigen (HBsAg) in a Haimen City, China Cohort.” 2012. Thesis, Drexel University. Accessed January 22, 2021. http://hdl.handle.net/1860/3953.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Kim, John. “Quantification of Hepatitis B Surface Antigen (HBsAg) in a Haimen City, China Cohort.” 2012. Web. 22 Jan 2021.

Vancouver:

Kim J. Quantification of Hepatitis B Surface Antigen (HBsAg) in a Haimen City, China Cohort. [Internet] [Thesis]. Drexel University; 2012. [cited 2021 Jan 22]. Available from: http://hdl.handle.net/1860/3953.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Kim J. Quantification of Hepatitis B Surface Antigen (HBsAg) in a Haimen City, China Cohort. [Thesis]. Drexel University; 2012. Available from: http://hdl.handle.net/1860/3953

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

28. Guo, Yi. Interplay between microRNA and Hepatitis B virus replication.

Degree: 2013, Drexel University

URL: http://hdl.handle.net/1860/4239

►

Chronic infection with the hepatitis B virus (HBV), which affects 350 million people worldwide, is an important global health issue. Virus-mediated changes in normal cellular… (more)

▼

Chronic infection with the hepatitis B virus (HBV), which affects 350 million people worldwide, is an important global health issue. Virus-mediated changes in normal cellular physiology of hepatocytes, the main target cell of HBV, are considered to facilitate persistent and chronic infection of HBV, potentially leading to the development of HBV-associated liver cancer. Recent work with microRNAs (miRNAs) has shown that many cell types express distinct profiles of miRNAs specifically suited for regulating normal cellular function. This is particularly apparent in hepatocytes, where a single miRNA, mircoRNA-122 (miR-122), makes up at least 50% of the total miRNAs in the cell. Given the important role of miRNAs in regulating cellular function, and the particular importance of miR-122 to hepatocytes, we hypothesize that the levels of miR-122 in the cell may directly influence HBV replication, which may in turn regulate levels of miR-122. To address this hypothesis, the expression levels of miR-122 in HepG2.215 cells, which stably express HBV, were compared to their parental cell line, HepG2. Levels of miR-122 were significantly higher in HepG2.215 cells compared to HepG2. We then measured miR-122 using a luciferase reporter system in which luciferase activity is directly proportional to the amount of functional miR-122. These results, however, indicated minimal alteration of levels of miR-122 between these two cell lines. Also, when HepG2 cells were transfected with a plasmid expressing the HBV genome, HBV failed to elevate miR-122 levels, despite the presence of HBV proteins. On the other hand, exploring the effects of miR-122 expression on HBV replication showed that miR-122 enhanced HBV replication in transfected HepG2 cells in a dose dependent manner. These results may help explain why HBV specifically infects hepatocytes, the only cell type known to express significant levels of miR-122. Additionally, an assay was developed to confirm the authenticity of isolated primary rat hepatocytes using real-time reverse transcription-polymerase chain reaction for hepatocyte specific markers. Future work will replicate these miR-122 experiments in this more biologically relevant system. Together, while the effect of HBV infection on miR-122 expression remains controversial, these results do suggest a potential role for miR-122 in enhancing HBV replication.

M.S., Biomedical Science – Drexel University, 2013

Advisors/Committee Members: Bouchard, Michael.

Subjects/Keywords: Biomedical engineering; Hepatitis B virus; RNA viruses

10 more images…

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APA (6^th Edition):

Guo, Y. (2013). Interplay between microRNA and Hepatitis B virus replication. (Thesis). Drexel University. Retrieved from http://hdl.handle.net/1860/4239

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Guo, Yi. “Interplay between microRNA and Hepatitis B virus replication.” 2013. Thesis, Drexel University. Accessed January 22, 2021. http://hdl.handle.net/1860/4239.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Guo, Yi. “Interplay between microRNA and Hepatitis B virus replication.” 2013. Web. 22 Jan 2021.

Vancouver:

Guo Y. Interplay between microRNA and Hepatitis B virus replication. [Internet] [Thesis]. Drexel University; 2013. [cited 2021 Jan 22]. Available from: http://hdl.handle.net/1860/4239.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Guo Y. Interplay between microRNA and Hepatitis B virus replication. [Thesis]. Drexel University; 2013. Available from: http://hdl.handle.net/1860/4239

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Drexel University

29. Obikoya-Malomo, Monisola A. Prevalence of Hepatitis B Infection among African Immigrants in the Greater Philadelphia Area.

Degree: 2012, Drexel University

URL: http://hdl.handle.net/1860/3945

►

Hepatitis B virus (HBV) infection is a major global health problem. It is the most important life threatening viral hepatitis and most common liver infection… (more)

Subjects/Keywords: Public Health; African Immigrants; Hepatitis B; Philadelphia

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APA (6^th Edition):

Obikoya-Malomo, M. A. (2012). Prevalence of Hepatitis B Infection among African Immigrants in the Greater Philadelphia Area. (Thesis). Drexel University. Retrieved from http://hdl.handle.net/1860/3945

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Obikoya-Malomo, Monisola A. “Prevalence of Hepatitis B Infection among African Immigrants in the Greater Philadelphia Area.” 2012. Thesis, Drexel University. Accessed January 22, 2021. http://hdl.handle.net/1860/3945.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Obikoya-Malomo, Monisola A. “Prevalence of Hepatitis B Infection among African Immigrants in the Greater Philadelphia Area.” 2012. Web. 22 Jan 2021.

Vancouver:

Obikoya-Malomo MA. Prevalence of Hepatitis B Infection among African Immigrants in the Greater Philadelphia Area. [Internet] [Thesis]. Drexel University; 2012. [cited 2021 Jan 22]. Available from: http://hdl.handle.net/1860/3945.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Obikoya-Malomo MA. Prevalence of Hepatitis B Infection among African Immigrants in the Greater Philadelphia Area. [Thesis]. Drexel University; 2012. Available from: http://hdl.handle.net/1860/3945

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Stellenbosch University

30. Bates, William D. Hepatitis-B-associated glomerular disease : a clinicopathological study of Hepatitis B virus associated Membranous Glomerulonephritis in Namibian and South African children 1974 - 2005 and a comparison with Hepatitis B associated Membranous Glomerulonephritis as well as Idiopathic Membranous Glomerulonephritis in adults.

Degree: DMed, Medicine, 2011, Stellenbosch University

URL: http://hdl.handle.net/10019.1/38011

► ENGLISH ABSTRACT: Background and Objective: The most common cause of severe proteinuria/nephrotic syndrome (NS) in children worldwide is minimal change disease (MCD). This is also… (more)

▼ ENGLISH ABSTRACT: Background and Objective: The most common cause of severe proteinuria/nephrotic syndrome (NS) in children worldwide is minimal change disease (MCD). This is also the pattern observed in white and Indian children in South Africa (SA). By contrast, black and mixed race/coloured children of Southern Africa in the 1960s to 1990s were shown to have a different pattern of NS. One of the main differences was the frequency of hepatitis B virus (HBV) associated glomerulonephritis, usually membranous glomerulonephritis (MGN). The objective of this project was a clinicopathological study of this subgroup of nephrotic children to document the disease further and in particular to seek correlations between pathological and clinical features including prognosis. A central focus was to document the detailed ultrastructural examination of the renal biopsies of these children and to correlate the spectrum of pathological features with demographic, clinical, laboratory and prognostic features. The hypothesis was that the clinicopathological features of HBV MGN in children differed substantially from idiopathic MGN in general (children and adults) and also from HBV MGN in adults and that HBV MGN in children should be viewed as a distinct disease. Patients and methods: The childhood (12 years and younger) patient cohort was 309 children with severe proteinuria/nephrotic syndrome who presented at Tygerberg Hospital (TBH) over a 21 year period from 1974-1995, including 67 children from Namibia. The study group was 71 children with HBV MGN who were followed up to 2005. The comparative adult group was 45 adults with MGN of whom 12 had HBV MGN and 33 idiopathic MGN. (A comparison could not be made with idiopathic MGN in childhood as this centre only had 2 such patients during the study period.) Demographic, clinical, laboratory and renal pathology data were collected, compared and correlated. Results: HBV associated MGN was the most frequent cause of NS in the Namibian subgroup, 25/67 (37%) and the third most frequent, 71/309 (23%) in the childhood cohort as a whole. The MGN group was 86% (71/83) of the total HBV childhood nephrotic cohort, by far the dominant subgroup. The average age of the 71 children with HBV MGN was 6.0 years (range 2-12 years) at presentation and boys comprised 80% of the group. Hepatitis B envelope antigen (HBeAg) was identified in the serum of 87% of children tested. Laboratory features different from idiopathic MGN included more prominent haematuria, mildly raised serum transaminases and more frequently lowered serum C3 and C4 levels. Light microscopic examination of renal biopsies showed mesangial proliferation in all patients but with minimal glomerular sclerosis and interstitial disease. On ultrastructural examination mesangial and subendothelial deposits were common and prominent as was mesangial interposition. The MGN of HBV in children therefore frequently showed mesangiocapillary glomerulonephritis (MCGN) features in addition to the subepithelial… Advisors/Committee Members: Moosa, M. R., Stellenbosch University. Faculty of Medicine and Health Sciences. Dept. of Medicine. General Internal medicine..

Subjects/Keywords: Nephrotic syndrome in children; Hepatitis B virus

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APA (6^th Edition):

Bates, W. D. (2011). Hepatitis-B-associated glomerular disease : a clinicopathological study of Hepatitis B virus associated Membranous Glomerulonephritis in Namibian and South African children 1974 - 2005 and a comparison with Hepatitis B associated Membranous Glomerulonephritis as well as Idiopathic Membranous Glomerulonephritis in adults. (Thesis). Stellenbosch University. Retrieved from http://hdl.handle.net/10019.1/38011

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Bates, William D. “Hepatitis-B-associated glomerular disease : a clinicopathological study of Hepatitis B virus associated Membranous Glomerulonephritis in Namibian and South African children 1974 - 2005 and a comparison with Hepatitis B associated Membranous Glomerulonephritis as well as Idiopathic Membranous Glomerulonephritis in adults.” 2011. Thesis, Stellenbosch University. Accessed January 22, 2021. http://hdl.handle.net/10019.1/38011.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Bates, William D. “Hepatitis-B-associated glomerular disease : a clinicopathological study of Hepatitis B virus associated Membranous Glomerulonephritis in Namibian and South African children 1974 - 2005 and a comparison with Hepatitis B associated Membranous Glomerulonephritis as well as Idiopathic Membranous Glomerulonephritis in adults.” 2011. Web. 22 Jan 2021.

Vancouver:

Bates WD. Hepatitis-B-associated glomerular disease : a clinicopathological study of Hepatitis B virus associated Membranous Glomerulonephritis in Namibian and South African children 1974 - 2005 and a comparison with Hepatitis B associated Membranous Glomerulonephritis as well as Idiopathic Membranous Glomerulonephritis in adults. [Internet] [Thesis]. Stellenbosch University; 2011. [cited 2021 Jan 22]. Available from: http://hdl.handle.net/10019.1/38011.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Bates WD. Hepatitis-B-associated glomerular disease : a clinicopathological study of Hepatitis B virus associated Membranous Glomerulonephritis in Namibian and South African children 1974 - 2005 and a comparison with Hepatitis B associated Membranous Glomerulonephritis as well as Idiopathic Membranous Glomerulonephritis in adults. [Thesis]. Stellenbosch University; 2011. Available from: http://hdl.handle.net/10019.1/38011

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Open Access Theses and Dissertations