subject:(Heparin)

Oregon State University

1. Fry, Allyson Kaye. Synthesis and anticoagulant function of heparin containing block copolymers on polystyrene microspheres.

Degree: MS, Chemical Engineering, 2008, Oregon State University

URL: http://hdl.handle.net/1957/8926

► Contact of blood with the surfaces of synthetic materials is associated with spontaneous protein adsorption, initiating platelet aggregation, the coagulation cascade, and the eventual development… (more)

Subjects/Keywords: heparin; Heparin

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APA (6^th Edition):

Fry, A. K. (2008). Synthesis and anticoagulant function of heparin containing block copolymers on polystyrene microspheres. (Masters Thesis). Oregon State University. Retrieved from http://hdl.handle.net/1957/8926

Chicago Manual of Style (16^th Edition):

Fry, Allyson Kaye. “Synthesis and anticoagulant function of heparin containing block copolymers on polystyrene microspheres.” 2008. Masters Thesis, Oregon State University. Accessed March 04, 2021. http://hdl.handle.net/1957/8926.

MLA Handbook (7^th Edition):

Fry, Allyson Kaye. “Synthesis and anticoagulant function of heparin containing block copolymers on polystyrene microspheres.” 2008. Web. 04 Mar 2021.

Vancouver:

Fry AK. Synthesis and anticoagulant function of heparin containing block copolymers on polystyrene microspheres. [Internet] [Masters thesis]. Oregon State University; 2008. [cited 2021 Mar 04]. Available from: http://hdl.handle.net/1957/8926.

Council of Science Editors:

Fry AK. Synthesis and anticoagulant function of heparin containing block copolymers on polystyrene microspheres. [Masters Thesis]. Oregon State University; 2008. Available from: http://hdl.handle.net/1957/8926

Michigan State University

2. Zhang, Jicheng (Graduate of Michigan State University). Chemical synthesis of heparin like head to tail multimers.

Degree: 2020, Michigan State University

URL: http://etd.lib.msu.edu/islandora/object/etd:48392

►

Thesis Ph. D. Michigan State University. Chemistry 2020.

Heparin, a heterogeneously sulfated glycosaminoglycan (GAG), consists of -1,4-linked glucosamine (GlcN) and uronic acid [either D-glucuronic acid… (more)

Subjects/Keywords: Heparin; Heparin – Synthesis; Polysaccharides – Structure; Organic chemistry

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APA (6^th Edition):

Zhang, J. (. o. M. S. U. (2020). Chemical synthesis of heparin like head to tail multimers. (Thesis). Michigan State University. Retrieved from http://etd.lib.msu.edu/islandora/object/etd:48392

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Zhang, Jicheng (Graduate of Michigan State University). “Chemical synthesis of heparin like head to tail multimers.” 2020. Thesis, Michigan State University. Accessed March 04, 2021. http://etd.lib.msu.edu/islandora/object/etd:48392.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Zhang, Jicheng (Graduate of Michigan State University). “Chemical synthesis of heparin like head to tail multimers.” 2020. Web. 04 Mar 2021.

Vancouver:

Zhang J(oMSU. Chemical synthesis of heparin like head to tail multimers. [Internet] [Thesis]. Michigan State University; 2020. [cited 2021 Mar 04]. Available from: http://etd.lib.msu.edu/islandora/object/etd:48392.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Zhang J(oMSU. Chemical synthesis of heparin like head to tail multimers. [Thesis]. Michigan State University; 2020. Available from: http://etd.lib.msu.edu/islandora/object/etd:48392

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Debrecen

3. Timári, István. Heparin-analóg szénhidrátszármazékok szerkezetének és antitrombin -III fehérjével való kölcsönhatásának vizsgálata NMR spektroszkópiával .

Degree: DE – TEK – Természettudományi és Technológiai Kar – Kémiai Intézet, 2012, University of Debrecen

URL: http://hdl.handle.net/2437/128597

► A heparin régóta ismert és alkalmazott véralvadásgátló poliszacharid az orvosi gyakorlatban. Több kutatócsoport is sikeresen előállított olyan heparin-analóg származékokat, amelyek a heparinhoz képest kedvezőbb farmakológiai… (more)

Subjects/Keywords: NMR spektroszkópia; heparin

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APA (6^th Edition):

Timári, I. (2012). Heparin-analóg szénhidrátszármazékok szerkezetének és antitrombin -III fehérjével való kölcsönhatásának vizsgálata NMR spektroszkópiával . (Thesis). University of Debrecen. Retrieved from http://hdl.handle.net/2437/128597

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Timári, István. “Heparin-analóg szénhidrátszármazékok szerkezetének és antitrombin -III fehérjével való kölcsönhatásának vizsgálata NMR spektroszkópiával .” 2012. Thesis, University of Debrecen. Accessed March 04, 2021. http://hdl.handle.net/2437/128597.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Timári, István. “Heparin-analóg szénhidrátszármazékok szerkezetének és antitrombin -III fehérjével való kölcsönhatásának vizsgálata NMR spektroszkópiával .” 2012. Web. 04 Mar 2021.

Vancouver:

Timári I. Heparin-analóg szénhidrátszármazékok szerkezetének és antitrombin -III fehérjével való kölcsönhatásának vizsgálata NMR spektroszkópiával . [Internet] [Thesis]. University of Debrecen; 2012. [cited 2021 Mar 04]. Available from: http://hdl.handle.net/2437/128597.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Timári I. Heparin-analóg szénhidrátszármazékok szerkezetének és antitrombin -III fehérjével való kölcsönhatásának vizsgálata NMR spektroszkópiával . [Thesis]. University of Debrecen; 2012. Available from: http://hdl.handle.net/2437/128597

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Oregon State University

4. Bolsinger, Travis Samuel Sebastian. Human platelet adhesion to heparinized silica surfaces.

Degree: MS, Chemical Engineering, 2008, Oregon State University

URL: http://hdl.handle.net/1957/9292

► Heparin was modified and immobilized to surface-activated silica surfaces using two different reaction schemes. End-aminated heparin was reacted with 2-iminothiolane to produce free thiol groups… (more)

Subjects/Keywords: Heparin; Blood platelets – Aggregation

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APA (6^th Edition):

Bolsinger, T. S. S. (2008). Human platelet adhesion to heparinized silica surfaces. (Masters Thesis). Oregon State University. Retrieved from http://hdl.handle.net/1957/9292

Chicago Manual of Style (16^th Edition):

Bolsinger, Travis Samuel Sebastian. “Human platelet adhesion to heparinized silica surfaces.” 2008. Masters Thesis, Oregon State University. Accessed March 04, 2021. http://hdl.handle.net/1957/9292.

MLA Handbook (7^th Edition):

Bolsinger, Travis Samuel Sebastian. “Human platelet adhesion to heparinized silica surfaces.” 2008. Web. 04 Mar 2021.

Vancouver:

Bolsinger TSS. Human platelet adhesion to heparinized silica surfaces. [Internet] [Masters thesis]. Oregon State University; 2008. [cited 2021 Mar 04]. Available from: http://hdl.handle.net/1957/9292.

Council of Science Editors:

Bolsinger TSS. Human platelet adhesion to heparinized silica surfaces. [Masters Thesis]. Oregon State University; 2008. Available from: http://hdl.handle.net/1957/9292

University of Utah

5. Meola, Stacy D. Evaluation of antithrombogenic drug combination therapy utilizing an in vitro and ex vivo stent model;.

Degree: MS;, Pathology;, 2001, University of Utah

URL: http://content.lib.utah.edu/cdm/singleitem/collection/etd1/id/1516/rec/467

► Anticoagulant and antiplatelet agents are currently being used clinically during episodes of unstable angina and non-Q-wave myocardial infarctions to stop thrombus formation to decrease morbidly… (more)

Subjects/Keywords: Heparin; Thrombus

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APA (6^th Edition):

Meola, S. D. (2001). Evaluation of antithrombogenic drug combination therapy utilizing an in vitro and ex vivo stent model;. (Masters Thesis). University of Utah. Retrieved from http://content.lib.utah.edu/cdm/singleitem/collection/etd1/id/1516/rec/467

Chicago Manual of Style (16^th Edition):

Meola, Stacy D. “Evaluation of antithrombogenic drug combination therapy utilizing an in vitro and ex vivo stent model;.” 2001. Masters Thesis, University of Utah. Accessed March 04, 2021. http://content.lib.utah.edu/cdm/singleitem/collection/etd1/id/1516/rec/467.

MLA Handbook (7^th Edition):

Meola, Stacy D. “Evaluation of antithrombogenic drug combination therapy utilizing an in vitro and ex vivo stent model;.” 2001. Web. 04 Mar 2021.

Vancouver:

Meola SD. Evaluation of antithrombogenic drug combination therapy utilizing an in vitro and ex vivo stent model;. [Internet] [Masters thesis]. University of Utah; 2001. [cited 2021 Mar 04]. Available from: http://content.lib.utah.edu/cdm/singleitem/collection/etd1/id/1516/rec/467.

Council of Science Editors:

Meola SD. Evaluation of antithrombogenic drug combination therapy utilizing an in vitro and ex vivo stent model;. [Masters Thesis]. University of Utah; 2001. Available from: http://content.lib.utah.edu/cdm/singleitem/collection/etd1/id/1516/rec/467

Clemson University

6. Ghobrial, Nardine M. Using Heparin-Coated Nanoparticles in the Treatment of Neointimal Hyperplasia.

Degree: PhD, Bioengineering, 2020, Clemson University

URL: https://tigerprints.clemson.edu/all_dissertations/2674

► The use of stents in the treatment of atherosclerosis leads to a potential risk of restenosis, caused by neointimal hyperplasia. Neointimal hyperplasia is mainly… (more)

▼ The use of stents in the treatment of atherosclerosis leads to a potential risk of restenosis, caused by neointimal hyperplasia. Neointimal hyperplasia is mainly caused by an injury to the endothelial layer of the blood vessel followed by the proliferation of smooth muscle cells into the lumen of the blood vessel. To address this, we designed a magnetically-guided drug delivery system to locally deliver heparin to a stented artery. The nanoparticles were synthesized, characterized, and tested on relevant human cell lines. The particles were non-toxic to human smooth muscle cells, endothelial cells, and fibroblasts. They reduced the proliferation of the smooth muscle cells and increased the proliferation of endothelial cells at concentrations as low as 10 μg/mL. The particles also shifted the smooth muscle cells from their synthetic phenotype to their contractile phenotype. The capture of the nanoparticles by the stent struts, under relevant magnetic field and blood velocity was modeled using COMSOL Multiphysics. The coronary artery was modeled using a 2D axisymmetric model with stainless steel stent struts. A Magnetic field of 1 T was applied to magnetize the stent struts. Three different strut geometries were compared for their effect of the capture efficiency. The model had a capture efficiency 0f 34-42%, which is comparable to models using the same particle sizes. Ex vivo organ culture studies using porcine right coronary arteries were performed. The arteries were conditioned either statically in cell culture flasks or dynamically in an organ culture bioreactor. Nanoparticles reduced intimal thickening in and expressed contractile properties in the treated arteries compared to the controls. We were successfully able to synthesize heparin-coated magnetic nanoparticles and achieve high heparin loading. Particle capture efficiency around the stent in the ex vivo porcine artery model was found to be similar to that predicted by the computational model. Consistent with the prior results of systemic heparin delivery, the nanoparticles reduce the proliferation and dedifferentiation of vascular smooth muscle cells while promoting endothelialization, both in vitro and ex vivo. Thus, these particles may be a promising treatment option for neointimal hyperplasia. . Advisors/Committee Members: Delphine Dean, Olin T Mefford, Jeoungsoo Lee, Ulf Schiller.

Subjects/Keywords: Cardiovascular; Hemodynamics; Heparin; Magnetic; Nanoparticles

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APA (6^th Edition):

Ghobrial, N. M. (2020). Using Heparin-Coated Nanoparticles in the Treatment of Neointimal Hyperplasia. (Doctoral Dissertation). Clemson University. Retrieved from https://tigerprints.clemson.edu/all_dissertations/2674

Chicago Manual of Style (16^th Edition):

Ghobrial, Nardine M. “Using Heparin-Coated Nanoparticles in the Treatment of Neointimal Hyperplasia.” 2020. Doctoral Dissertation, Clemson University. Accessed March 04, 2021. https://tigerprints.clemson.edu/all_dissertations/2674.

MLA Handbook (7^th Edition):

Ghobrial, Nardine M. “Using Heparin-Coated Nanoparticles in the Treatment of Neointimal Hyperplasia.” 2020. Web. 04 Mar 2021.

Vancouver:

Ghobrial NM. Using Heparin-Coated Nanoparticles in the Treatment of Neointimal Hyperplasia. [Internet] [Doctoral dissertation]. Clemson University; 2020. [cited 2021 Mar 04]. Available from: https://tigerprints.clemson.edu/all_dissertations/2674.

Council of Science Editors:

Ghobrial NM. Using Heparin-Coated Nanoparticles in the Treatment of Neointimal Hyperplasia. [Doctoral Dissertation]. Clemson University; 2020. Available from: https://tigerprints.clemson.edu/all_dissertations/2674

McMaster University

7. Chung, Jason. A THROMBOELASTOGRAPHY STUDY ON THE EVALUATION OF CLOT FORMATION IN PLATELET-DEPLETED WHOLE BLOOD IN THE PRESENCE OF UNFRACTIONATED HEPARIN OR LOW-MOLECULAR WEIGHT HEPARIN.

Degree: MSc, 2015, McMaster University

URL: http://hdl.handle.net/11375/18361

►

The use of an appropriate anticoagulation regiment for the treatment of venous thromboembolism (VTE) in patients with concomitant thrombocytopenia is based on anecdotal evidence and… (more)

▼

The use of an appropriate anticoagulation regiment for the treatment of venous thromboembolism (VTE) in patients with concomitant thrombocytopenia is based on anecdotal evidence and the opinions of managing physicians. The current guidelines suggest that therapeutic levels of anticoagulants may be safely administered to patients who have a minimum platelet count of 50 x 109/L. However, it has recently been suggested that the minimal platelet threshold for safe anticoagulation treatment can be provided at a reduced platelet count of 30 x 109/L. Thus, in order evaluate these platelet threshold we used a thromboelastography (TEG) model to evaluate the clotting parameters of whole blood at predefined platelet counts in the presence of unfractionated heparin (UFH) and low-molecular weight heparin (LMWH). Due to the importance of red blood cells on hemostasis a whole blood TEG model was designed in order to mimic in vivo hemostasis. Clotting was initiated using different concentrations of tissue factor for each anticoagulant at therapeutic and prophylactic levels of UFH and LMWH at predefined platelet counts. In the presence of therapeutic concentrations of either UFH or LMWH, there were no significant differences in TEG parameters of whole blood clots between platelet counts of 30 x 109/L and 50 x 109/L when clotting was driven by the extrinsic pathway. At prophylactic levels of LMWH clot formation was less compromised. Furthermore, no significant difference was noted between platelet-depleted blood (PDB; <10 x 109/L) and 30 x 109/L with respect to r-time. This suggests LMWH at prophylactic levels has no significant bearing on clot formation at a lower platelet threshold versus therapeutic levels of LMWH. Overall, it shows that clot formation is similar for UFH and LMWH when platelet counts are reduced from 50 x 109/L to 30 x 109/L. This work provides insight on the potential for anticoagulation at a reduced platelet threshold in thrombocytopenic conditions.

Thesis

Master of Science (MSc)

Advisors/Committee Members: Chan, Howard, Health Sciences.

Subjects/Keywords: Thrombocytopenia; Thromboelastography; Heparin; Platelets

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APA (6^th Edition):

Chung, J. (2015). A THROMBOELASTOGRAPHY STUDY ON THE EVALUATION OF CLOT FORMATION IN PLATELET-DEPLETED WHOLE BLOOD IN THE PRESENCE OF UNFRACTIONATED HEPARIN OR LOW-MOLECULAR WEIGHT HEPARIN. (Masters Thesis). McMaster University. Retrieved from http://hdl.handle.net/11375/18361

Chicago Manual of Style (16^th Edition):

Chung, Jason. “A THROMBOELASTOGRAPHY STUDY ON THE EVALUATION OF CLOT FORMATION IN PLATELET-DEPLETED WHOLE BLOOD IN THE PRESENCE OF UNFRACTIONATED HEPARIN OR LOW-MOLECULAR WEIGHT HEPARIN.” 2015. Masters Thesis, McMaster University. Accessed March 04, 2021. http://hdl.handle.net/11375/18361.

MLA Handbook (7^th Edition):

Chung, Jason. “A THROMBOELASTOGRAPHY STUDY ON THE EVALUATION OF CLOT FORMATION IN PLATELET-DEPLETED WHOLE BLOOD IN THE PRESENCE OF UNFRACTIONATED HEPARIN OR LOW-MOLECULAR WEIGHT HEPARIN.” 2015. Web. 04 Mar 2021.

Vancouver:

Chung J. A THROMBOELASTOGRAPHY STUDY ON THE EVALUATION OF CLOT FORMATION IN PLATELET-DEPLETED WHOLE BLOOD IN THE PRESENCE OF UNFRACTIONATED HEPARIN OR LOW-MOLECULAR WEIGHT HEPARIN. [Internet] [Masters thesis]. McMaster University; 2015. [cited 2021 Mar 04]. Available from: http://hdl.handle.net/11375/18361.

Council of Science Editors:

Chung J. A THROMBOELASTOGRAPHY STUDY ON THE EVALUATION OF CLOT FORMATION IN PLATELET-DEPLETED WHOLE BLOOD IN THE PRESENCE OF UNFRACTIONATED HEPARIN OR LOW-MOLECULAR WEIGHT HEPARIN. [Masters Thesis]. McMaster University; 2015. Available from: http://hdl.handle.net/11375/18361

University of Debrecen

8. Mező, Erika. Különböző útvonalak szulfonsav-tartalmú heparinoid triszacharid szintézisére .

Degree: DE – TEK – Természettudományi és Technológiai Kar – Kémiai Intézet, 2011, University of Debrecen

URL: http://hdl.handle.net/2437/107468

A diplomamunka szulfonsav-tartalmú heparinoid triszacharid szintézisét foglalja magába. Advisors/Committee Members: Lázár, László (advisor).

Subjects/Keywords: heparin; triszacharid

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APA (6^th Edition):

Mező, E. (2011). Különböző útvonalak szulfonsav-tartalmú heparinoid triszacharid szintézisére . (Thesis). University of Debrecen. Retrieved from http://hdl.handle.net/2437/107468

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Mező, Erika. “Különböző útvonalak szulfonsav-tartalmú heparinoid triszacharid szintézisére .” 2011. Thesis, University of Debrecen. Accessed March 04, 2021. http://hdl.handle.net/2437/107468.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Mező, Erika. “Különböző útvonalak szulfonsav-tartalmú heparinoid triszacharid szintézisére .” 2011. Web. 04 Mar 2021.

Vancouver:

Mező E. Különböző útvonalak szulfonsav-tartalmú heparinoid triszacharid szintézisére . [Internet] [Thesis]. University of Debrecen; 2011. [cited 2021 Mar 04]. Available from: http://hdl.handle.net/2437/107468.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Mező E. Különböző útvonalak szulfonsav-tartalmú heparinoid triszacharid szintézisére . [Thesis]. University of Debrecen; 2011. Available from: http://hdl.handle.net/2437/107468

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Debrecen

9. Takács, Róbert. A heparin indulálta thrombocytopénia laboratóriumi diagnosztikája .

Degree: DE – Általános Orvostudományi Kar, University of Debrecen

URL: http://hdl.handle.net/2437/201475

► A heparin terápia egyik súlyos következményekkel járó immunmediált mellékhatása a heparin-indukálta thrombocytopénia (HIT). Kialakulása mai napig magas morbiditással és moralitással jár. Klinikai jellegzetessége a heparin… (more)

▼ A heparin terápia egyik súlyos következményekkel járó immunmediált mellékhatása a heparin-indukálta thrombocytopénia (HIT). Kialakulása mai napig magas morbiditással és moralitással jár. Klinikai jellegzetessége a heparin terápia megkezdését követő 5. – 14. napon megfigyelhető thrombocytopénia, valamint prothromboticus állapot kialakulása. A tünetek hátterében a 4-es vérlemezke faktor (PF4) heparinhoz történő kapcsolódása következtében kialakuló PF4/heparin komplex ellen termelődő IgG típusú antitestek megjelenése áll. Az antitestek a thrombocyták felszínén található FcγIIa receptorokhoz (CD32) való kapcsolódás révén aktiválják a vérlemezkéket aminek hatására prothromboticus mikropartikulumok felszabadulása és a thrombocyták consumptiója következik be. Ugyanezen antitestek thrombocyta aktiváló hatásuk mellett az endothelsejteket valamint a monocytákat is aktiválva további prothromboticus folyamatokat indítanak be. Ezek a folyamtok közösen vezetnek a közepes fokú thrombocytopénia (60 – 90 G/L) és az emelkedett thrombosis hajlam kialakulásához. A HIT diagnózisa nem állítható fel kizárólag a klinikai tünetek alapján. Erre csak az IgG típusú HIT antitest laboratóriumi kimutatását követően kerülhet sor. Célunk a rendelkezésünkre álló nemzetközi szakirodalom felhasználásával bemutatni a HIT diagnosztizálásában szerepet játszó laboratóriumi módszereket, valamint a Debreceni Egyetem Orvos- és Egészségtudományi Centrum (DEOEC) Laboratóriumi Medicina Intézete (LMI) által alkalmazott HIT vizsgálati panelt. A HIT panel magába foglalja a thrombocyta szám meghatározását, partikulált gél immunoassayn (PaGIA) és ELISA teszt elvégzését illetve áramlási citométerrel elvégzett funkcionális vizsgálatot. A vizsgálati panel bevezetése óta a Laboratóriumi Medicina Intézetben 156 esetben indult kivizsgálás a HIT irányába, melyből 5 esetben igazolódott funkcionális teszttel is megerősített HIT. Mind a 156 beteg esetén elvégzésre került a PaGIA és ELISA teszt. Pozitív ELISA minták esetén áramlási citométerrel végzett funkcionális tesztet is végeztünk. Vizsgálati eredményeinket a nemzetközi szakirodalomban megtalálható adatokkal összevetve értékeltük. Advisors/Committee Members: Kerényi, Adrienne (advisor), Debreceni Egyetem::Orvos- és Egészségtudományi Centrum::Általános Orvostudományi Kar::Laboratóriumi Medicina Intézet (advisor).

Subjects/Keywords: heparin; thrombocytopénia

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APA (6^th Edition):

Takács, R. (n.d.). A heparin indulálta thrombocytopénia laboratóriumi diagnosztikája . (Thesis). University of Debrecen. Retrieved from http://hdl.handle.net/2437/201475

Note: this citation may be lacking information needed for this citation format:
No year of publication.
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Takács, Róbert. “A heparin indulálta thrombocytopénia laboratóriumi diagnosztikája .” Thesis, University of Debrecen. Accessed March 04, 2021. http://hdl.handle.net/2437/201475.

Note: this citation may be lacking information needed for this citation format:
No year of publication.
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Takács, Róbert. “A heparin indulálta thrombocytopénia laboratóriumi diagnosztikája .” Web. 04 Mar 2021.

Note: this citation may be lacking information needed for this citation format:
No year of publication.

Vancouver:

Takács R. A heparin indulálta thrombocytopénia laboratóriumi diagnosztikája . [Internet] [Thesis]. University of Debrecen; [cited 2021 Mar 04]. Available from: http://hdl.handle.net/2437/201475.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
No year of publication.

Council of Science Editors:

Takács R. A heparin indulálta thrombocytopénia laboratóriumi diagnosztikája . [Thesis]. University of Debrecen; Available from: http://hdl.handle.net/2437/201475

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
No year of publication.

Boston University

10. Teran, Madelane. Modulation of vascular endothelial growth factor receptor affinity by neuropilin-1 and heparan sulfate proteoglycans.

Degree: PhD, Biochemistry, 2016, Boston University

URL: http://hdl.handle.net/2144/14590

► Angiogenesis is a highly regulated process orchestrated by the vascular endothelial growth factor-A (VEGF-A) system of ligands and receptors. Heparin/heparan sulfate (HS) proteoglycans and neuropilin-1… (more)

▼ Angiogenesis is a highly regulated process orchestrated by the vascular endothelial growth factor-A (VEGF-A) system of ligands and receptors. Heparin/heparan sulfate (HS) proteoglycans and neuropilin-1 (NRP-1) have been identified as co-receptors for VEGF-A, yet the mechanisms of action have not been fully defined. In the present study, we characterized molecular interactions between receptors and co-receptors and the two major VEGF-A isoforms, using surface plasmon resonance (SPR) and in vitro binding assays. We found that VEGF dissociated 25-times faster from its major signaling receptor, VEGF receptor-2 (VEGFR-2) than from its “decoy” receptor, VEGF receptor-1 (VEGFR-1). We identified a potential mechanism for co-receptors to decrease the dissociation rate and prolong the signaling complex lifetime. Using a systematic approach, we obtained kinetic parameters for each individual interaction in an intercomparable way to measure the effect NRP-1 and HS have on complex stability. Additionally, we demonstrated that these binding events influence VEGF activity within endothelial cells. These parameters can be used in mathematical models to predict therapy outcomes in defined cellular contexts. Furthermore, we optimized a competition-based technique using SPR and structurally defined HS oligosaccharides and demonstrated that it can be used to rapidly measure affinities to HS-binding proteins. We used this method to define interactions and structural and length requirements for heparin/HS interactions with VEGFR-1, NRP-1, and VEGF165, the most relevant VEGF-A isoform, in complex with VEGFR-2 and NRP-1. We show that the structural requirements were distinct for each interaction. We further found that VEGF165, VEGFR-2 and monomeric NRP-1 bound weakly to heparin alone, yet binding to heparin increased synergistically when presented together. This enhanced binding correlated with alterations in VEGF signaling in endothelial cells. We found that soluble NRP-1 increased VEGF binding and activated phosphorylation of VEGFR-2 and Erk1/2 in endothelial cells, and that these effects required sulfated HS. These data suggest that the presence of HS/heparin and NRP-1 may dictate the specific receptor type activated by VEGF and ultimately determine the biological output. The ability of co-receptors to fine-tune VEGF responsiveness suggests the possibility that VEGF-mediated angiogenesis can be selectively stimulated or inhibited by targeting HS/heparin and NRP-1.

Subjects/Keywords: Biochemistry; Heparin; Proteoglycans; Endothelial; Vascular

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APA (6^th Edition):

Teran, M. (2016). Modulation of vascular endothelial growth factor receptor affinity by neuropilin-1 and heparan sulfate proteoglycans. (Doctoral Dissertation). Boston University. Retrieved from http://hdl.handle.net/2144/14590

Chicago Manual of Style (16^th Edition):

Teran, Madelane. “Modulation of vascular endothelial growth factor receptor affinity by neuropilin-1 and heparan sulfate proteoglycans.” 2016. Doctoral Dissertation, Boston University. Accessed March 04, 2021. http://hdl.handle.net/2144/14590.

MLA Handbook (7^th Edition):

Teran, Madelane. “Modulation of vascular endothelial growth factor receptor affinity by neuropilin-1 and heparan sulfate proteoglycans.” 2016. Web. 04 Mar 2021.

Vancouver:

Teran M. Modulation of vascular endothelial growth factor receptor affinity by neuropilin-1 and heparan sulfate proteoglycans. [Internet] [Doctoral dissertation]. Boston University; 2016. [cited 2021 Mar 04]. Available from: http://hdl.handle.net/2144/14590.

Council of Science Editors:

Teran M. Modulation of vascular endothelial growth factor receptor affinity by neuropilin-1 and heparan sulfate proteoglycans. [Doctoral Dissertation]. Boston University; 2016. Available from: http://hdl.handle.net/2144/14590

University of Hong Kong

11. 劉泳欣. Cloning and characterization of heparanase 2 in rat brain.

Degree: 2016, University of Hong Kong

URL: http://hdl.handle.net/10722/225186

Subjects/Keywords: Heparin; Brain

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APA (6^th Edition):

劉泳欣. (2016). Cloning and characterization of heparanase 2 in rat brain. (Thesis). University of Hong Kong. Retrieved from http://hdl.handle.net/10722/225186

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

劉泳欣. “Cloning and characterization of heparanase 2 in rat brain.” 2016. Thesis, University of Hong Kong. Accessed March 04, 2021. http://hdl.handle.net/10722/225186.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

劉泳欣. “Cloning and characterization of heparanase 2 in rat brain.” 2016. Web. 04 Mar 2021.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete

Vancouver:

劉泳欣. Cloning and characterization of heparanase 2 in rat brain. [Internet] [Thesis]. University of Hong Kong; 2016. [cited 2021 Mar 04]. Available from: http://hdl.handle.net/10722/225186.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

劉泳欣. Cloning and characterization of heparanase 2 in rat brain. [Thesis]. University of Hong Kong; 2016. Available from: http://hdl.handle.net/10722/225186

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation

University of Hong Kong

12. Lau, Wing-yan. Cloning and characterization of heparanase 2 in rat brain.

Degree: 2016, University of Hong Kong

URL: http://hdl.handle.net/10722/238186

► Synaptic activity modulates the density of synaptic AMPARs, thereby affecting synaptic function, learning and memory. The molecular mechanisms regulating AMPAR trafficking is under intense interest.… (more)

▼ Synaptic activity modulates the density of synaptic AMPARs, thereby affecting synaptic function, learning and memory. The molecular mechanisms regulating AMPAR trafficking is under intense interest. Heparan sulfates (HS) of perineuronal proteoglycans are implicated in controlling the open-state of AMPA receptor-ion channels for maintaining synaptic strength. Heparanase 1 (Hpa1) is an endoglycosidase that cleaves heparan sulfate (HS) polysaccharides on HS proteoglycans (HSPGs). Its pro-form which is however enzymatically inactive induces internalization of HSPGs and AMPARs at post-synaptic terminal in neurons, resulting in decrease in synaptic strength and long-term potentiation (LTP). Its homolog, heparanase 2 (Hpa2), with about 40% homology is found expressed in the human brain, were found interacting with heparanase 1. We hypothesize that Hpa2 is expressed in rat brain and secreted from the hippocampal neurons, interact with hpa1 and regulate synaptic plasticity. In this project the expression, localization and secretion of Hpa2 were studied in rat brain. It is found heparanase 2 expression is highest among different distinct brain region. Hippocampal DIV14-16 neurons in culture from embryonic (E)17-18 rats and adult rat brain slices are adopted for localization analysis. Immunohistochemical staining on brain slice demonstrated that Hpa2 was localized at the CA1, CA3 and DG region in the hippocampus and Fix cell immunocytochemistry showed Hpa2 was co-localized with syndecan-3 in the nucleus, while in live cell staining hpa2 were found on cell surface co-localized with unknown HSPG. RT-PCR and Western blot analysis showed the presence of Hpa2 in hippocampal neurons at in In our hippocampal neuron culture model, Hpa2 is secreted from hippocampal neurons culture spontaneously. We pursue to study the signaling that regulates the neuronal production/secretion of Hpa2. Hpa2 exocytosis by the hippocampal neurons was enhanced by protein kinase C (PKC) activation and protein kinase A (PKA) inhibition. To figure out if hpa2 release is activity dependent, TTX and BIC were added to the hippocampal neuron cultures to induce synaptic scaling. Yet, hpa2 release and synthesis is not affected. In order to fully understand the function of hpa2, we aimed to produce recombinant hpa2. We discovered a new isoform of rat heparanase 2 which has 98% of similarity with human hpa2. The hpa2 isoform is successfully cloned and a stable expression cell line of hpa2 in HEK293 cell is developed. Taken together, the findings from the experiments support the hypothesis to show Hpa2 is expressed, localized and secreted in the rat hippocampal and hippocampal neurons. However, the function of heparanase 2 in hippocampus, especial its role in regulation of synaptic plasticity remain to be revealed.

Subjects/Keywords: Brain; Heparin

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APA (6^th Edition):

Lau, W. (2016). Cloning and characterization of heparanase 2 in rat brain. (Thesis). University of Hong Kong. Retrieved from http://hdl.handle.net/10722/238186

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Lau, Wing-yan. “Cloning and characterization of heparanase 2 in rat brain.” 2016. Thesis, University of Hong Kong. Accessed March 04, 2021. http://hdl.handle.net/10722/238186.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Lau, Wing-yan. “Cloning and characterization of heparanase 2 in rat brain.” 2016. Web. 04 Mar 2021.

Vancouver:

Lau W. Cloning and characterization of heparanase 2 in rat brain. [Internet] [Thesis]. University of Hong Kong; 2016. [cited 2021 Mar 04]. Available from: http://hdl.handle.net/10722/238186.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Lau W. Cloning and characterization of heparanase 2 in rat brain. [Thesis]. University of Hong Kong; 2016. Available from: http://hdl.handle.net/10722/238186

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Georgia Tech

13. Lei, Jennifer. The development of glycosaminoglycan coatings for mesenchymal stem cell-based culture applications.

Degree: PhD, Mechanical Engineering, 2016, Georgia Tech

URL: http://hdl.handle.net/1853/54949

► Mesenchymal stem cells are multipotent cells that have the ability to differentiate down multiple lineages as well as secrete trophic and anti-inflammatory factors. These qualities… (more)

▼ Mesenchymal stem cells are multipotent cells that have the ability to differentiate down multiple lineages as well as secrete trophic and anti-inflammatory factors. These qualities make MSCs a promising cell source for cell-based therapies to treat a variety of injuries and pathologies. Biomaterials are often used to control and direct stem cell behavior by engineering a desired environment around the cells. Recent research has focused on using the naturally derived sulfated glycosaminoglycan (GAG), heparin as a biomaterial due to its negative charge and ability to sequester and bind positively charged growth factors. Engineering a heparin coating that can mimic the native heparan sulfate proteoglycan structure found at cell surfaces can be used as a novel platform to present GAGs to cells to direct cell behavior. The overall goal of this dissertation was to develop GAG-based coatings on MSC spheroids in order to study the role of heparin and its derivatives on MSC culture applications. To investigate the role of heparin in coating form on MSC behavior, the ability of the coating to sequester positively charged growth factors was characterized. Given the role of sulfation in the negative charge density of heparin and growth factor interactions, a desulfated heparin coating was develop and used to examine how presentation of coatings with native and no sulfation levels could potentiate response to growth factors in the surrounding environment. Additionally, heparin and growth factor binding in coating presentation was explored to develop a novel platform to assemble MSC-based microtissues. Together these studies provided valuable insight into a novel approach to direct cell behavior by engineering a coating that harnesses heparin interactions with the surrounding environment. Advisors/Committee Members: Temenoff, Johnna S. (advisor), Botchwey, Edward A. (committee member), Guldberg, Robert E. (committee member), McDevitt, Todd C. (committee member), Murphy, William L. (committee member).

Subjects/Keywords: Heparin; Mesenchymal stem cells

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APA (6^th Edition):

Lei, J. (2016). The development of glycosaminoglycan coatings for mesenchymal stem cell-based culture applications. (Doctoral Dissertation). Georgia Tech. Retrieved from http://hdl.handle.net/1853/54949

Chicago Manual of Style (16^th Edition):

Lei, Jennifer. “The development of glycosaminoglycan coatings for mesenchymal stem cell-based culture applications.” 2016. Doctoral Dissertation, Georgia Tech. Accessed March 04, 2021. http://hdl.handle.net/1853/54949.

MLA Handbook (7^th Edition):

Lei, Jennifer. “The development of glycosaminoglycan coatings for mesenchymal stem cell-based culture applications.” 2016. Web. 04 Mar 2021.

Vancouver:

Lei J. The development of glycosaminoglycan coatings for mesenchymal stem cell-based culture applications. [Internet] [Doctoral dissertation]. Georgia Tech; 2016. [cited 2021 Mar 04]. Available from: http://hdl.handle.net/1853/54949.

Council of Science Editors:

Lei J. The development of glycosaminoglycan coatings for mesenchymal stem cell-based culture applications. [Doctoral Dissertation]. Georgia Tech; 2016. Available from: http://hdl.handle.net/1853/54949

University of Georgia

14. Kawatkar, Arati Vijay. Heparan sulfate synthesis.

Degree: 2014, University of Georgia

URL: http://hdl.handle.net/10724/22146

► This thesis presents the results of our investigation into the development of a modular approach for the synthesis of heparin and heparan sulfates. A suitable… (more)

Subjects/Keywords: Glycosoaminoglycans; Heparan sulfate; heparin

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APA (6^th Edition):

Kawatkar, A. V. (2014). Heparan sulfate synthesis. (Thesis). University of Georgia. Retrieved from http://hdl.handle.net/10724/22146

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Kawatkar, Arati Vijay. “Heparan sulfate synthesis.” 2014. Thesis, University of Georgia. Accessed March 04, 2021. http://hdl.handle.net/10724/22146.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Kawatkar, Arati Vijay. “Heparan sulfate synthesis.” 2014. Web. 04 Mar 2021.

Vancouver:

Kawatkar AV. Heparan sulfate synthesis. [Internet] [Thesis]. University of Georgia; 2014. [cited 2021 Mar 04]. Available from: http://hdl.handle.net/10724/22146.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Kawatkar AV. Heparan sulfate synthesis. [Thesis]. University of Georgia; 2014. Available from: http://hdl.handle.net/10724/22146

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

The Ohio State University

15. Vercellotti, John Raymond. The structure of heparin.

Degree: PhD, Graduate School, 1963, The Ohio State University

URL: http://rave.ohiolink.edu/etdc/view?acc_num=osu1486553441669325

Subjects/Keywords: Chemistry; Heparin

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APA (6^th Edition):

Vercellotti, J. R. (1963). The structure of heparin. (Doctoral Dissertation). The Ohio State University. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=osu1486553441669325

Chicago Manual of Style (16^th Edition):

Vercellotti, John Raymond. “The structure of heparin.” 1963. Doctoral Dissertation, The Ohio State University. Accessed March 04, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=osu1486553441669325.

MLA Handbook (7^th Edition):

Vercellotti, John Raymond. “The structure of heparin.” 1963. Web. 04 Mar 2021.

Vancouver:

Vercellotti JR. The structure of heparin. [Internet] [Doctoral dissertation]. The Ohio State University; 1963. [cited 2021 Mar 04]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=osu1486553441669325.

Council of Science Editors:

Vercellotti JR. The structure of heparin. [Doctoral Dissertation]. The Ohio State University; 1963. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=osu1486553441669325

The Ohio State University

16. Tomomatsu, Hideo. Structural studies on herapin.

Degree: PhD, Graduate School, 1965, The Ohio State University

URL: http://rave.ohiolink.edu/etdc/view?acc_num=osu14865679584659

Subjects/Keywords: Chemistry; Heparin

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APA (6^th Edition):

Tomomatsu, H. (1965). Structural studies on herapin. (Doctoral Dissertation). The Ohio State University. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=osu14865679584659

Chicago Manual of Style (16^th Edition):

Tomomatsu, Hideo. “Structural studies on herapin.” 1965. Doctoral Dissertation, The Ohio State University. Accessed March 04, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=osu14865679584659.

MLA Handbook (7^th Edition):

Tomomatsu, Hideo. “Structural studies on herapin.” 1965. Web. 04 Mar 2021.

Vancouver:

Tomomatsu H. Structural studies on herapin. [Internet] [Doctoral dissertation]. The Ohio State University; 1965. [cited 2021 Mar 04]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=osu14865679584659.

Council of Science Editors:

Tomomatsu H. Structural studies on herapin. [Doctoral Dissertation]. The Ohio State University; 1965. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=osu14865679584659

University of Arkansas

17. Morris, Jacqueline Anastasia. Heparin-Peptide Interactions.

Degree: PhD, 2016, University of Arkansas

URL: https://scholarworks.uark.edu/etd/2645

► Heparin is a polydispersed sulfated molecule that is part of the family called glycosaminoglycans found in the extracellular matrix and cell surfaces. This molecule… (more)

▼ Heparin is a polydispersed sulfated molecule that is part of the family called glycosaminoglycans found in the extracellular matrix and cell surfaces. This molecule is extremely important for the activation of proteins and protein-receptor interactions that are responsible for downstream cell signaling pathways. Heparin has been isolated from porcine intestine and used as an anticoagulant for the prevention of embolisms, heart thrombosis, and clotting during heart surgeries. This so-called miracle drug was in use until 2008, when isolated batches were found to be contaminated with other glycosaminoglycans similar to heparin. From 2008, there has been a dire need for a more cost-effective purification of heparin in good yield, to remove the contaminants. Heparin has also been used for affinity chromatography to purify heparin-binding proteins. Recombinant protein purification is an important aspect of biotechnology, with a heavy emphasis on developing easy purification systems for large quantities of homogeneously pure therapeutic proteins at low costs. Several affinity tags have been employed to aid in the expression and purification of various proteins. There are, however, various disadvantages, such as interference with the target protein structure, unsuitable elution conditions, multiple-step purification procedures, and many others. In this context, a novel heparin-binding peptide (HB-peptide) was designed based on the heparin-binding region of acidic fibroblast growth factor (FGF-1). The HB-peptide has been shown to bind to heparin with better affinity than other glycosaminoglycans. A one-step Heparin-Sepharose-based purification procedure was developed for various recombinant proteins using mild elution conditions. Using proteolytic cleavage, the affinity tag was removed to obtain a folded protein. Polyclonal antibodies were also grown against the specific sequence of the HB-peptide, which then were used to successfully and specifically bind fusion proteins that only contained the HB-peptide even at the nanogram level. HB-peptide was then coupled onto a solid matrix to be used as an affinity column, in a similar fashion as heparin-Sepharose with HBPs. A mixture of glycosaminoglycans were separated from each other for the most part. In this context, our HB-peptide can be used as a means to separate glycosaminoglycans, yielding pure heparin for future medical use. Advisors/Committee Members: Thallapuranam Kumar, Roger Koeppe, Jingyi Chen.

Subjects/Keywords: Affinity Tag; Heparin; Heparin-binding Proteins; Analytical Chemistry; Biochemistry

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APA (6^th Edition):

Morris, J. A. (2016). Heparin-Peptide Interactions. (Doctoral Dissertation). University of Arkansas. Retrieved from https://scholarworks.uark.edu/etd/2645

Chicago Manual of Style (16^th Edition):

Morris, Jacqueline Anastasia. “Heparin-Peptide Interactions.” 2016. Doctoral Dissertation, University of Arkansas. Accessed March 04, 2021. https://scholarworks.uark.edu/etd/2645.

MLA Handbook (7^th Edition):

Morris, Jacqueline Anastasia. “Heparin-Peptide Interactions.” 2016. Web. 04 Mar 2021.

Vancouver:

Morris JA. Heparin-Peptide Interactions. [Internet] [Doctoral dissertation]. University of Arkansas; 2016. [cited 2021 Mar 04]. Available from: https://scholarworks.uark.edu/etd/2645.

Council of Science Editors:

Morris JA. Heparin-Peptide Interactions. [Doctoral Dissertation]. University of Arkansas; 2016. Available from: https://scholarworks.uark.edu/etd/2645

University of Hong Kong

18. Yeung, Man-nga. Functional roles of heparanase in endochondral ossification.

Degree: 2009, University of Hong Kong

URL: http://hdl.handle.net/10722/56792

Subjects/Keywords: Endochondral ossification.; Heparin.

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Yeung, M. (2009). Functional roles of heparanase in endochondral ossification. (Thesis). University of Hong Kong. Retrieved from http://hdl.handle.net/10722/56792

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Yeung, Man-nga. “Functional roles of heparanase in endochondral ossification.” 2009. Thesis, University of Hong Kong. Accessed March 04, 2021. http://hdl.handle.net/10722/56792.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Yeung, Man-nga. “Functional roles of heparanase in endochondral ossification.” 2009. Web. 04 Mar 2021.

Vancouver:

Yeung M. Functional roles of heparanase in endochondral ossification. [Internet] [Thesis]. University of Hong Kong; 2009. [cited 2021 Mar 04]. Available from: http://hdl.handle.net/10722/56792.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Yeung M. Functional roles of heparanase in endochondral ossification. [Thesis]. University of Hong Kong; 2009. Available from: http://hdl.handle.net/10722/56792

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

19. Καστελλοριζιός, Μιχαήλ. Σύνδεση λιποσωμικών μορφών σε επιφάνειες, που έχουν τροποποιηθεί κατάλληλα με τεχνολογία πλάσματος, με ομοιοπολικό δεσμό.

Degree: 2012, University of Patras

URL: http://hdl.handle.net/10889/5278

►

Τις τελευταίες δεκαετίες υπάρχει μια αυξανόμενη ζήτηση για βιοσυμβατά υλικά ικανά να χρησιμοποιηθούν σαν πρόσθετα στο ανθρώπινο σώμα, σαν βάσεις για ελεγχόμενη χορήγηση βιοδραστικών ενώσεων,… (more)

▼

Τις τελευταίες δεκαετίες υπάρχει μια αυξανόμενη ζήτηση για βιοσυμβατά υλικά ικανά να χρησιμοποιηθούν σαν πρόσθετα στο ανθρώπινο σώμα, σαν βάσεις για ελεγχόμενη χορήγηση βιοδραστικών ενώσεων, σαν εμφυτεύματα κ.α. χωρίς να προκαλούν ανοσοποιητική αντίδραση από τον αργανισμό. Μέχρι και σήμερα δεν έχει βρεθεί το υλικό που θα ξεγελάσει τους αμυντικούς μηχανισμούς του σώματος, με άλλα λόγια, να είναι αόρατο από το σώμα. Έχουν γίνει πολλές προσπάθειες και έχουν εφαρμοστεί διάφορες προσεγγίσεις. Τα τελευταία χρόνια όλο και περισσότερες ερευνητικές ομάδες επενδύουν σε υλικά τα οποία απελευθερώνουν ελεγχόμενα βιοδραστικές ουσίες που καταστέλουν την αντίδραση του οργανισμού. Μια τέτοια ουσία είναι η ηπαρίνη, ένα φυσικό αντιπηκτικό το οποίο μπορεί να χρησιμοποιηθεί για την αύξηση της αιμοσυμβατότητας αρτηριακών ενδοπροσθέσεων. Αναπτύξαμε μια μέθοδο για την ομοιοπολική, μη αναστρέψιμη πρόσδεση λιποσωμάτων σε μεταλλικές επιφάνειες, οι οποίες έχουν υποστεί επεξεργασία με τεχνολογία πλάσματος. Οι επιφάνειες φέρουν ελεύθερες καρβοξυλομάδες τις οποίες μπορούμε να εκμεταλλευτούμε για να συζεύξουμε πάνω τους λιποσώματα με αμινομάδες στην επιφάνειά τους (functionalized), μέσω δημιουργίας αμιδικού δεσμού. Οι μεταλλικές επιφάνειες που χρησιμοποιήσαμε ήταν SS-316 μεταλλικοί δίσκοι επεξεργασμένοι με τεχνολογία πλάσματος, και τις προμηθευτήκαμε από το Τμήμα Χημικών Μηχανικών του Πανεπιστημίου Πατρών και από το τμήμα Χημείας του Πανεπιστημίου του Μπάρι. Χρησιμοποιήσαμε μικρά μονοστιβαδιακά λιποσώματα (SUV) διαμέτρου της τάξης των 100 nm, με διάφορες λιπιδικές συστάσεις (PC, PC:Chol 4:1, DSPC:Chol 2:1). Χαρακτηρίσαμε τα functionalized λιποσώματά ως προς την ικανότητά τους να εγκλωβίζουν ηπαρίνη, το μέγεθος, τη διασπορά μεγέθους, το φορτίο της επιφάνειάς τους και τη σταθερότητά τους σε διάφορες συνθήκες. Τα αποτελέσματά μας δείχνουν ότι γενικά τα functionalized λιποσώματα συμπεριφέρονται σαν τυπικά λιποσώματα που φέρουν λιπίδιο με PEG ομάδα (pegylated λιποσώματα), ενώ για βέλτιστο εγκλωβισμό ηπαρίνης σημαντικό είναι το στάδιο λυοφιλοποίησης / επανασύστασης κατά την παρασκευή τους. Αποδείξαμε ότι τα functionalized λιποσώματα μπορούν να προσδεθούν σε μεταλλικές επιφάνειες (κατάλληλα επεξεργασμένες) διατηρώντας τη δομή τους και φέροντας ηπαρίνη ή άλλη υδρόφιλη ουσία στο εσωτερικό τους. Εφαρμόσαμε ένα απλό πρωτόκολλο δημιουργίας αμιδικού δεσμού, και το βελτιστοποιήσαμε ώστε να πάρουμε μέγιστη απόδοση στη σύνδεση των λιποσωμάτων στις επιφάνειες (58,4 ± 8.6 μg λιπιδίου ανά cm2 επιφάνειας).

Over the last couple of decades there has been an increasing need for more biocompatible, more “body friendly” materials that can be used in cases of subcutaneous, endoarterial or other type of implantations, as artificial body parts, drug releasing bases or biosensor implantations. The main desired quality of these materials is the lack to trigger the body’s defensive mechanisms and foreign body response reactions. Up to this date there has not been a material with the ability to camouflage itself and be invisible to the human body. Lately, scientists show…

Advisors/Committee Members: Αντιμησιάρη, Σοφία, Kastellorizios, Michael, Αντιμησιάρη, Σοφία, Κλεπετσάνης, Παύλος, Ματαράς, Δημήτριος.

Subjects/Keywords: Λιποσώματα; Ηπαρίνη; Επαναστένωση; 571.655; Liposomes; Heparin; Restenosis

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Καστελλοριζιός, �. (2012). Σύνδεση λιποσωμικών μορφών σε επιφάνειες, που έχουν τροποποιηθεί κατάλληλα με τεχνολογία πλάσματος, με ομοιοπολικό δεσμό. (Masters Thesis). University of Patras. Retrieved from http://hdl.handle.net/10889/5278

Chicago Manual of Style (16^th Edition):

Καστελλοριζιός, Μιχαήλ. “Σύνδεση λιποσωμικών μορφών σε επιφάνειες, που έχουν τροποποιηθεί κατάλληλα με τεχνολογία πλάσματος, με ομοιοπολικό δεσμό.” 2012. Masters Thesis, University of Patras. Accessed March 04, 2021. http://hdl.handle.net/10889/5278.

MLA Handbook (7^th Edition):

Καστελλοριζιός, Μιχαήλ. “Σύνδεση λιποσωμικών μορφών σε επιφάνειες, που έχουν τροποποιηθεί κατάλληλα με τεχνολογία πλάσματος, με ομοιοπολικό δεσμό.” 2012. Web. 04 Mar 2021.

Vancouver:

Καστελλοριζιός �. Σύνδεση λιποσωμικών μορφών σε επιφάνειες, που έχουν τροποποιηθεί κατάλληλα με τεχνολογία πλάσματος, με ομοιοπολικό δεσμό. [Internet] [Masters thesis]. University of Patras; 2012. [cited 2021 Mar 04]. Available from: http://hdl.handle.net/10889/5278.

Council of Science Editors:

Καστελλοριζιός �. Σύνδεση λιποσωμικών μορφών σε επιφάνειες, που έχουν τροποποιηθεί κατάλληλα με τεχνολογία πλάσματος, με ομοιοπολικό δεσμό. [Masters Thesis]. University of Patras; 2012. Available from: http://hdl.handle.net/10889/5278

Georgia Tech

20. Tellier, Liane Elizabeth. Controlled heparin-based delivery strategies to promote musculoskeletal tissue regeneration after injury.

Degree: PhD, Biomedical Engineering (Joint GT/Emory Department), 2018, Georgia Tech

URL: http://hdl.handle.net/1853/62183

► Despite the prevalence of musculoskeletal disorders, one of the leading causes of work- related disability in the United States, effective therapeutic delivery to the affected… (more)

▼ Despite the prevalence of musculoskeletal disorders, one of the leading causes of work- related disability in the United States, effective therapeutic delivery to the affected musculoskeletal tissues such as bone, cartilage, and muscle remains a significant challenge. Thus, the long term goal of this research was to develop a tunable biomaterial-based system for the delivery of regenerative therapeutics to musculoskeletal tissues. This goal was approached through the engineering of a heparin-based microparticle (MP) system with tunable heparin sulfation, heparin content, and hydrolytic degradation, which was subsequently employed for in vitro release of an osteoinductive growth factor and in vivo delivery of a chondroprotective anti-inflammatory protein and a chemokine capable of recruiting pro-regenerative cells to muscle. In aim 1, hydrolytically-degradable, heparin-based MPs were fabricated containing heparin derivatives of varying levels of sulfation, and N-desulfated heparin MPs were found to efficiently load and release an osteoinductive growth factor, bone morphogenetic protein-2 (BMP-2), in vitro. In aim 2, heparin-based MPs were loaded with tumor necrosis factor- stimulated gene-6 (TSG-6), an anti-inflammatory protein known to inhibit plasmin, and delivered via intra-articular injection to rat knees in the context of post-traumatic osteoarthritis. After 21 days, TSG-6 loaded MPs reduced cartilage damage following injury, whereas a 3X higher dose of soluble TSG-6 did not, suggesting that Hep-N can enhance TSG-6 bioactivity in vivo and that Hep-N-based MPs can effectively deliver a chondroprotective protein for cartilage regeneration. Finally, in aim 3, heparin-based MPs were loaded with the chemokine stromal cell-derived factor- 1 (SDF-1) and delivered via local injection to the supraspinatus muscle in combination with systemic delivery of the bone marrow mobilizing agent, VPC01091, following severe rotator cuff injury in rats. Co-delivery of SDF-1 loaded MPs and VPC01091 led to significant modulation of the inflammatory cellular milieu and mesenchymal stem cell population in muscle 3 and 7 days following injury, along with significantly more regenerating muscle fibers compared to either treatment alone. Overall, in this thesis, heparin-based MPs were utilized to deliver therapeutics capable of stimulating endogenous healing processes in two unique contexts of cartilage and muscle degeneration. Given the tunability of the MP system and the ability for heparin to bind and interact with a myriad of proteins, the application of heparin-based MPs extends beyond cartilage and muscle, and may be used for a wide range of applications where controlled release of bioactive positively-charged therapeutics is required. Advisors/Committee Members: Temenoff, Johnna S. (advisor), Willett, Nick J. (committee member), Guldberg, Robert E. (committee member), Jarrett, Claude D. (committee member), Botchwey, Edward A. (committee member).

Subjects/Keywords: Heparin; Microparticles; Drug delivery; Endogenous healing

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Tellier, L. E. (2018). Controlled heparin-based delivery strategies to promote musculoskeletal tissue regeneration after injury. (Doctoral Dissertation). Georgia Tech. Retrieved from http://hdl.handle.net/1853/62183

Chicago Manual of Style (16^th Edition):

Tellier, Liane Elizabeth. “Controlled heparin-based delivery strategies to promote musculoskeletal tissue regeneration after injury.” 2018. Doctoral Dissertation, Georgia Tech. Accessed March 04, 2021. http://hdl.handle.net/1853/62183.

MLA Handbook (7^th Edition):

Tellier, Liane Elizabeth. “Controlled heparin-based delivery strategies to promote musculoskeletal tissue regeneration after injury.” 2018. Web. 04 Mar 2021.

Vancouver:

Tellier LE. Controlled heparin-based delivery strategies to promote musculoskeletal tissue regeneration after injury. [Internet] [Doctoral dissertation]. Georgia Tech; 2018. [cited 2021 Mar 04]. Available from: http://hdl.handle.net/1853/62183.

Council of Science Editors:

Tellier LE. Controlled heparin-based delivery strategies to promote musculoskeletal tissue regeneration after injury. [Doctoral Dissertation]. Georgia Tech; 2018. Available from: http://hdl.handle.net/1853/62183

University of Toronto

21. Wat, Jovian Ming Wai. Heparin for the Prevention of Preeclampsia: The Role of Non-anticoagulant Mechanisms.

Degree: PhD, 2020, University of Toronto

URL: http://hdl.handle.net/1807/100905

► Preeclampsia is a serious disorder of pregnancy characterized by new-onset hypertension with evidence of organ damage. The severe, early-onset form of preeclampsia with fetal growth… (more)

▼ Preeclampsia is a serious disorder of pregnancy characterized by new-onset hypertension with evidence of organ damage. The severe, early-onset form of preeclampsia with fetal growth restriction originates from impaired spiral artery remodeling during early pregnancy, resulting in poor placental function later in pregnancy. Small randomized clinical trials have determined that low molecular weight heparin (LMWH) could effectively prevent preeclampsia, while recent multi-center trials showed no effect. The mechanisms by which LMWH could confer protection against the development of preeclampsia, anticoagulant or non-anticoagulant, have not been thoroughly investigated. Elucidating the mechanisms of LMWH for the prevention of preeclampsia could provide insight into which women may benefit from LWMH therapy. In this thesis, the hypothesis that anticoagulation-independent mechanisms of LMWH mediate the protective effects against features of preeclampsia in the rat reduced uterine perfusion pressure (RUPP) model was tested using a non-anticoagulant derivative of LMWH, termed glycol-split heparin. The non-anticoagulant properties of glycol-split heparin were first validated against dalteparin, a clinically utilized LMWH, through a series of in vitro experiments. Glycol-split heparin demonstrated similar properties to dalteparin, including stimulating the release of placental growth factor from first trimester human placental villous explants; promoting angiogenic tube formation by cultured endothelial cells; and inhibiting complement activation and leukocyte adhesion. Results from rat studies demonstrated that, although dalteparin was unable to suppress the development of hypertension in the RUPP model of preeclampsia, dalteparin significantly improved fetal growth and normalized placental labyrinth structure disrupted by model induction. However, glycol-split heparin did not elicit the same fetoplacental effects as dalteparin, and was comparable to vehicle-treated RUPP rats. The data presented in this thesis provide novel insights into the mechanistic effects of LMWH for the prevention of preeclampsia, suggesting that LMWH may mediate improvements in placental function and fetal growth. LMWH therapy may therefore be most beneficial for the subset of patients at risk of the severe early-onset phenotype of preeclampsia, characterized by placental dysfunction and fetal growth restriction. These findings provide the basis for future experimental and clinical studies to elucidate the role of LMWH as a potential preventative therapy against the development of severe early-onset preeclampsia. Advisors/Committee Members: Kingdom, John C, Laboratory Medicine and Pathobiology.

Subjects/Keywords: Fetal growth restriction; Heparin; Placenta; Preeclampsia; 0719

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Wat, J. M. W. (2020). Heparin for the Prevention of Preeclampsia: The Role of Non-anticoagulant Mechanisms. (Doctoral Dissertation). University of Toronto. Retrieved from http://hdl.handle.net/1807/100905

Chicago Manual of Style (16^th Edition):

Wat, Jovian Ming Wai. “Heparin for the Prevention of Preeclampsia: The Role of Non-anticoagulant Mechanisms.” 2020. Doctoral Dissertation, University of Toronto. Accessed March 04, 2021. http://hdl.handle.net/1807/100905.

MLA Handbook (7^th Edition):

Wat, Jovian Ming Wai. “Heparin for the Prevention of Preeclampsia: The Role of Non-anticoagulant Mechanisms.” 2020. Web. 04 Mar 2021.

Vancouver:

Wat JMW. Heparin for the Prevention of Preeclampsia: The Role of Non-anticoagulant Mechanisms. [Internet] [Doctoral dissertation]. University of Toronto; 2020. [cited 2021 Mar 04]. Available from: http://hdl.handle.net/1807/100905.

Council of Science Editors:

Wat JMW. Heparin for the Prevention of Preeclampsia: The Role of Non-anticoagulant Mechanisms. [Doctoral Dissertation]. University of Toronto; 2020. Available from: http://hdl.handle.net/1807/100905

NSYSU

22. Yin, Yao-De. The Utility of DNA Aptamers against Î²-Bungarotoxin as Sensors for Detecting Î²-Bungarotoxin, Coralyne and Heparin.

Degree: Master, Institute of Biomedical Sciences, 2018, NSYSU

URL: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0528118-084541

► Aptamers are single-stranded DNA or RNA fragments that bind to targeted molecules via folding into specific structure. Thus, aptamers can be employed as aptasensors for… (more)

▼ Aptamers are single-stranded DNA or RNA fragments that bind to targeted molecules via folding into specific structure. Thus, aptamers can be employed as aptasensors for detecting targeted molecules. The aim of this study was to investigate the utility of DNA aptamers against Bungarus multicinctus (Taiwan banded krait) presynaptic neurotoxin Î²-bungarotoxin (Î²-Bgt) as biosensors. Four Î²-Bgt aptamers, Bgt1, Bgt2, Bgt3, and Bgt4 were synthesized according to previously published results. Electrophoretic mobility shift assay showed that Î²-Bgt reduced the electrophoretic mobility of the aptamers. Moreover, Î²-Bgt reduced fluorescence intensity of the aptamers labeled with 5'-end carboxyfluorescein (FAM) and 3'-end 4-([4-(dimethylamino)-phenyl]azo)-benzoic acid (Dabcyl). These results showed that the folded structure of aptamers changed upon binding with Î²-Bgt. Measurement of the changes in FAM fluorescence revealed that Î²-Bgt had the highest binding affinity for Bgt1 among the four aptamers. In contrast to palmatine and berberine, coralyne drastically reduced FAM fluorescence intensity of 5'-FAM-Bgt1 and 5'-FAM-Bgt1-3'-Dabcyl, suggesting the selectivity of the sensors for detecting coralyne. The limit of detection (LOD) of coralyne determined by 5'-FAM-Bgt1 and 5'-FAM-Bgt1-3'-Dabcyl were 0.034 Î¼M and 0.021 Î¼M, respectively. Furthermore, coralyne-5'-FAM-Bgt1 and coralyne-5'-FAM-Bgt1-3'-Dabcyl complexes were employed as turn-on fluorescent sensors for detecting Î²-Bgt and heparin. Î²-Bgt and heparin notably restored FAM fluorescence intensity of coralyne-5'-FAM-Bgt1 and coralyne-5'-FAM-Bgt1-3'-Dabcyl complexes. The LOD of Î²-Bgt measured by coralyne-5'-FAM-Bgt1 and coralyne-5'-FAM-Bgt1-3'-Dabcyl complexes were 3.57 nM and 2.74 nM, respectively; the LOD of heparin were 0.012 Î¼g/ml and 0.004 Î¼g/ml, respectively; and the LOD for heparin-spiked serum were 0.027 Î¼g/ml and 0.009 Î¼g/ml, respectively. The sensor system constructed by coralyne and Bgt1 showed a high selectivity for heparin detection than for other glycosaminoglycans including chondroitin sulfate and hyaluronic acid. Although the sensor system effectively differentiated Î²-Bgt from other purified snake venom proteins, it could not specifically detect Taiwan banded krait crude venom. Taken together, our data indicate that aptamer against Î²-Bgt can be used for constructing biosensors for detecting coralyne and heparin. However, the sensor system is unable to identify the crude venoms of different snake species via Î²-Bgt detection. Advisors/Committee Members: Bin-Nan Wu (chair), Long-Sen Chang (committee member), Ying-Jung Chen (chair).

Subjects/Keywords: DNA aptamer; Sensors; Heparin; Coralyne; Î²-Bungarotoxin

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Yin, Y. (2018). The Utility of DNA Aptamers against Î²-Bungarotoxin as Sensors for Detecting Î²-Bungarotoxin, Coralyne and Heparin. (Thesis). NSYSU. Retrieved from http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0528118-084541

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Yin, Yao-De. “The Utility of DNA Aptamers against Î²-Bungarotoxin as Sensors for Detecting Î²-Bungarotoxin, Coralyne and Heparin.” 2018. Thesis, NSYSU. Accessed March 04, 2021. http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0528118-084541.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Yin, Yao-De. “The Utility of DNA Aptamers against Î²-Bungarotoxin as Sensors for Detecting Î²-Bungarotoxin, Coralyne and Heparin.” 2018. Web. 04 Mar 2021.

Vancouver:

Yin Y. The Utility of DNA Aptamers against Î²-Bungarotoxin as Sensors for Detecting Î²-Bungarotoxin, Coralyne and Heparin. [Internet] [Thesis]. NSYSU; 2018. [cited 2021 Mar 04]. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0528118-084541.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Yin Y. The Utility of DNA Aptamers against Î²-Bungarotoxin as Sensors for Detecting Î²-Bungarotoxin, Coralyne and Heparin. [Thesis]. NSYSU; 2018. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0528118-084541

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Oregon State University

23. Joshi, Omkar. Fibrinogen adsorption at heparinized silica interfaces : history dependence and protein concentration effects.

Degree: MS, Chemical Engineering, 2004, Oregon State University

URL: http://hdl.handle.net/1957/22631

► Adipic dihydrazide-modified heparin was prepared and subsequently immobilized on surface-activated silica wafers. X-ray photoelectron spectroscopy (XPS) was used to quantify the elemental composition of the… (more)

Subjects/Keywords: Heparin – Physiological effect

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Joshi, O. (2004). Fibrinogen adsorption at heparinized silica interfaces : history dependence and protein concentration effects. (Masters Thesis). Oregon State University. Retrieved from http://hdl.handle.net/1957/22631

Chicago Manual of Style (16^th Edition):

Joshi, Omkar. “Fibrinogen adsorption at heparinized silica interfaces : history dependence and protein concentration effects.” 2004. Masters Thesis, Oregon State University. Accessed March 04, 2021. http://hdl.handle.net/1957/22631.

MLA Handbook (7^th Edition):

Joshi, Omkar. “Fibrinogen adsorption at heparinized silica interfaces : history dependence and protein concentration effects.” 2004. Web. 04 Mar 2021.

Vancouver:

Joshi O. Fibrinogen adsorption at heparinized silica interfaces : history dependence and protein concentration effects. [Internet] [Masters thesis]. Oregon State University; 2004. [cited 2021 Mar 04]. Available from: http://hdl.handle.net/1957/22631.

Council of Science Editors:

Joshi O. Fibrinogen adsorption at heparinized silica interfaces : history dependence and protein concentration effects. [Masters Thesis]. Oregon State University; 2004. Available from: http://hdl.handle.net/1957/22631

Oregon State University

24. Lee, Hyo Jin. Fibrinogen adsorption at heparinized silica interfaces : history dependence and adsorption time effects.

Degree: MS, Chemical Engineering, 2004, Oregon State University

URL: http://hdl.handle.net/1957/22596

► Heparin was modified with adipic diliydrazide and covalently linked to surface-activated silica. Contact angle measurements were made to determine changes in surface at various stages… (more)

Subjects/Keywords: Heparin – Physiological effect

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Lee, H. J. (2004). Fibrinogen adsorption at heparinized silica interfaces : history dependence and adsorption time effects. (Masters Thesis). Oregon State University. Retrieved from http://hdl.handle.net/1957/22596

Chicago Manual of Style (16^th Edition):

Lee, Hyo Jin. “Fibrinogen adsorption at heparinized silica interfaces : history dependence and adsorption time effects.” 2004. Masters Thesis, Oregon State University. Accessed March 04, 2021. http://hdl.handle.net/1957/22596.

MLA Handbook (7^th Edition):

Lee, Hyo Jin. “Fibrinogen adsorption at heparinized silica interfaces : history dependence and adsorption time effects.” 2004. Web. 04 Mar 2021.

Vancouver:

Lee HJ. Fibrinogen adsorption at heparinized silica interfaces : history dependence and adsorption time effects. [Internet] [Masters thesis]. Oregon State University; 2004. [cited 2021 Mar 04]. Available from: http://hdl.handle.net/1957/22596.

Council of Science Editors:

Lee HJ. Fibrinogen adsorption at heparinized silica interfaces : history dependence and adsorption time effects. [Masters Thesis]. Oregon State University; 2004. Available from: http://hdl.handle.net/1957/22596

University of Debrecen

25. Shode, Deborah Temitope. Rare aspects of heparin-induced thrombocytopenia .

Degree: DE – Általános Orvostudományi Kar, University of Debrecen

URL: http://hdl.handle.net/2437/229981

Heparins are widely used anticoagulants but they are associated with limb-and life-threatening complications. This thesis discusses the rare but devastating pro-thrombotic complications of anticoagulant therapy which clinicans should be aware of. Advisors/Committee Members: Oláh, Zsolt (advisor), Debreceni Egyetem::Általános Orvostudományi Kar::Belgyógyászati Intézet (advisor).

Subjects/Keywords: Heparin; Induced; Thrombocytopenia

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APA (6^th Edition):

Shode, D. T. (n.d.). Rare aspects of heparin-induced thrombocytopenia . (Thesis). University of Debrecen. Retrieved from http://hdl.handle.net/2437/229981

Note: this citation may be lacking information needed for this citation format:
No year of publication.
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Shode, Deborah Temitope. “Rare aspects of heparin-induced thrombocytopenia .” Thesis, University of Debrecen. Accessed March 04, 2021. http://hdl.handle.net/2437/229981.

Note: this citation may be lacking information needed for this citation format:
No year of publication.
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Shode, Deborah Temitope. “Rare aspects of heparin-induced thrombocytopenia .” Web. 04 Mar 2021.

Note: this citation may be lacking information needed for this citation format:
No year of publication.

Vancouver:

Shode DT. Rare aspects of heparin-induced thrombocytopenia . [Internet] [Thesis]. University of Debrecen; [cited 2021 Mar 04]. Available from: http://hdl.handle.net/2437/229981.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
No year of publication.

Council of Science Editors:

Shode DT. Rare aspects of heparin-induced thrombocytopenia . [Thesis]. University of Debrecen; Available from: http://hdl.handle.net/2437/229981

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
No year of publication.

University of Debrecen

26. Varga, Eszter. Véralvadásgátló hatású pentaszacharid-szulfonsav származék szintézise .

Degree: DE – Gyógyszerésztudományi Kar, University of Debrecen

URL: http://hdl.handle.net/2437/227916

► Kutatócsoportunkban új típusú antikoagulánsok kifejlesztését tűztük ki célul, melyekben a heparin-analóg pentaszacharidok farmakofór szulfátészter-csoportjait bioizoszter metánszulfonsav-csoporttal helyettesítjük. Ezáltal a biológiai környezetben való stabilitás növekedését vártuk.… (more)

Subjects/Keywords: heparin; pentaszacharid; antikoaguláns

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APA (6^th Edition):

Varga, E. (n.d.). Véralvadásgátló hatású pentaszacharid-szulfonsav származék szintézise . (Thesis). University of Debrecen. Retrieved from http://hdl.handle.net/2437/227916

Note: this citation may be lacking information needed for this citation format:
No year of publication.
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Varga, Eszter. “Véralvadásgátló hatású pentaszacharid-szulfonsav származék szintézise .” Thesis, University of Debrecen. Accessed March 04, 2021. http://hdl.handle.net/2437/227916.

Note: this citation may be lacking information needed for this citation format:
No year of publication.
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Varga, Eszter. “Véralvadásgátló hatású pentaszacharid-szulfonsav származék szintézise .” Web. 04 Mar 2021.

Note: this citation may be lacking information needed for this citation format:
No year of publication.

Vancouver:

Varga E. Véralvadásgátló hatású pentaszacharid-szulfonsav származék szintézise . [Internet] [Thesis]. University of Debrecen; [cited 2021 Mar 04]. Available from: http://hdl.handle.net/2437/227916.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
No year of publication.

Council of Science Editors:

Varga E. Véralvadásgátló hatású pentaszacharid-szulfonsav származék szintézise . [Thesis]. University of Debrecen; Available from: http://hdl.handle.net/2437/227916

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
No year of publication.

Princeton University

27. Raitman Khutorskoy, Irene. HEPARIN-FIBRONECTIN INTERACTIONS IN THE DEVELOPMENT OF EXTRACELLULAR MATRIX INSOLUBILITY .

Degree: PhD, 2018, Princeton University

URL: http://arks.princeton.edu/ark:/88435/dsp01df65vb53b

► The extracellular matrix (ECM) is composed of a network of fibrous proteins and proteoglycans that together provide stability, support, and regulate cell behavior and organization.… (more)

▼ The extracellular matrix (ECM) is composed of a network of fibrous proteins and proteoglycans that together provide stability, support, and regulate cell behavior and organization. Fibronectin (FN) is one of these fibrous proteins, and cell-mediated interactions between FN dimers form fibrils that, over time, become insoluble. This insoluble FN matrix serves an important role as a foundational matrix for other ECM proteins to build upon. The insoluble nature of FN fibrils provides the ECM with its structure and rigidity, and is important for normal developmental processes. A dysregulation in the assembly or accumulation of these fibrils can lead to various developmental and progressive diseases. Understanding how FN fibrils become stable and thus insoluble can help in better understanding such complications. We have developed a procedure to isolate insoluble fibril fragments from a decellularized matrix using proteolysis, deoxycholate (DOC) detergent extraction, and gel electrophoresis. Analyses of these DOC-insoluble fragments using domain-specific antibodies and mass spectrometry have identified three regions that are resistant to proteolysis. Two of these regions contain known heparin/heparan sulfate (HS) binding sites in FN. To determine whether heparin-FN interactions facilitate fibril assembly, a HS-deficient CHO cell line was used for matrix assembly experiments. In the absence of heparin, these cells assembled a limited number of FN fibrils. In contrast, the addition of heparin significantly increased the amount of FN matrix. Time course experiments indicated that heparin acts at an early step in the assembly process, and is required to be present continuously for maximal matrix stimulation. Sulfated glycosaminoglycan (GAG) mimetics similarly increased FN assembly and demonstrated a dependence on GAG sulfation. The length of the heparin chains also played a role in assembly. Chains of sufficient length to bind to two FN molecules gave maximal stimulation of assembly, whereas shorter heparin had less of an effect. Heparin was also able to bind to multiple heparin-binding domain FN fragments, as revealed by size exclusion chromatography analyses. A model is proposed in which heparin/HS binding at the heparin-binding domains connects multiple FNs together and promotes conformational changes involved in forming insoluble protein interactions. Advisors/Committee Members: Schwarzbauer, Jean E (advisor).

Subjects/Keywords: extracellular matrix; fibronectin; glycosaminoglycans; heparin; matrix assembly

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Raitman Khutorskoy, I. (2018). HEPARIN-FIBRONECTIN INTERACTIONS IN THE DEVELOPMENT OF EXTRACELLULAR MATRIX INSOLUBILITY . (Doctoral Dissertation). Princeton University. Retrieved from http://arks.princeton.edu/ark:/88435/dsp01df65vb53b

Chicago Manual of Style (16^th Edition):

Raitman Khutorskoy, Irene. “HEPARIN-FIBRONECTIN INTERACTIONS IN THE DEVELOPMENT OF EXTRACELLULAR MATRIX INSOLUBILITY .” 2018. Doctoral Dissertation, Princeton University. Accessed March 04, 2021. http://arks.princeton.edu/ark:/88435/dsp01df65vb53b.

MLA Handbook (7^th Edition):

Raitman Khutorskoy, Irene. “HEPARIN-FIBRONECTIN INTERACTIONS IN THE DEVELOPMENT OF EXTRACELLULAR MATRIX INSOLUBILITY .” 2018. Web. 04 Mar 2021.

Vancouver:

Raitman Khutorskoy I. HEPARIN-FIBRONECTIN INTERACTIONS IN THE DEVELOPMENT OF EXTRACELLULAR MATRIX INSOLUBILITY . [Internet] [Doctoral dissertation]. Princeton University; 2018. [cited 2021 Mar 04]. Available from: http://arks.princeton.edu/ark:/88435/dsp01df65vb53b.

Council of Science Editors:

Raitman Khutorskoy I. HEPARIN-FIBRONECTIN INTERACTIONS IN THE DEVELOPMENT OF EXTRACELLULAR MATRIX INSOLUBILITY . [Doctoral Dissertation]. Princeton University; 2018. Available from: http://arks.princeton.edu/ark:/88435/dsp01df65vb53b

Michigan State University

28. Kepros, John Paul. Persistent beneficial effects of a novel nonanticoagulant heparin (GM1892) on cardiovascular and hepatic functions after trauma-hemorrhage and resuscitation.

Degree: MS, Department of Surgery, 1995, Michigan State University

URL: http://etd.lib.msu.edu/islandora/object/etd:25637

Subjects/Keywords: Heparin – Therapeutic use

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Kepros, J. P. (1995). Persistent beneficial effects of a novel nonanticoagulant heparin (GM1892) on cardiovascular and hepatic functions after trauma-hemorrhage and resuscitation. (Masters Thesis). Michigan State University. Retrieved from http://etd.lib.msu.edu/islandora/object/etd:25637

Chicago Manual of Style (16^th Edition):

Kepros, John Paul. “Persistent beneficial effects of a novel nonanticoagulant heparin (GM1892) on cardiovascular and hepatic functions after trauma-hemorrhage and resuscitation.” 1995. Masters Thesis, Michigan State University. Accessed March 04, 2021. http://etd.lib.msu.edu/islandora/object/etd:25637.

MLA Handbook (7^th Edition):

Kepros, John Paul. “Persistent beneficial effects of a novel nonanticoagulant heparin (GM1892) on cardiovascular and hepatic functions after trauma-hemorrhage and resuscitation.” 1995. Web. 04 Mar 2021.

Vancouver:

Kepros JP. Persistent beneficial effects of a novel nonanticoagulant heparin (GM1892) on cardiovascular and hepatic functions after trauma-hemorrhage and resuscitation. [Internet] [Masters thesis]. Michigan State University; 1995. [cited 2021 Mar 04]. Available from: http://etd.lib.msu.edu/islandora/object/etd:25637.

Council of Science Editors:

Kepros JP. Persistent beneficial effects of a novel nonanticoagulant heparin (GM1892) on cardiovascular and hepatic functions after trauma-hemorrhage and resuscitation. [Masters Thesis]. Michigan State University; 1995. Available from: http://etd.lib.msu.edu/islandora/object/etd:25637

Univerzitet u Beogradu

29. Petrović, Marija T., 1980-, 59182345. Značaj primene kombinovane terapije heparina i vežbanja kod bolesnika sa refraktornom anginom pektoris.

Degree: Medicinski fakultet, 2020, Univerzitet u Beogradu

URL: https://fedorabg.bg.ac.rs/fedora/get/o:22834/bdef:Content/get

►

Medicina - Kardiologija / Medicine - Cardiology

Terapijska arteriogeneza predstavlja novu terapijsku opciju za ove bolesnike sa refraktornom ishemijkom koronarnom bolesti. Cilj terapijske arteriogeneze je… (more)

▼

Medicina - Kardiologija / Medicine - Cardiology

Terapijska arteriogeneza predstavlja novu terapijsku opciju za ove bolesnike sa refraktornom ishemijkom koronarnom bolesti. Cilj terapijske arteriogeneze je da indukuje stvaranje novih krvnih sudova koji mogu da poboljšaju protok krvi u regionima koji nemaju adekvatno snabdevanje krvlju. Našim istraživenjem očekujemo da tokom perioda praćenja bolesnici koji budu dobijali heparin (H) zajedno sa fizičkim opterećenjem imaju više izraženu koronarnu arteriogenezu i kolateralnu cirkulaciju, manje tegoba po tipu stabilne srčane angine i manju ishemiju srčanog mišića na stresnoj ehokardiografiji. Ciljevi: ove studije, koja je uključivala bolesnike sa refraktornom srčanom anginom koji nisu kandidati za revaskularizaciju, su da se: 1. Proceni težina stabilne srčane angine pre i nakon fizičkog treninga. 2. Izračuna indeks pokretljivosti zidova leve komore pri maksimalnom opterećenju tokom stres egokardiografskog testa opterećenjem pre i nakon fizičkog treninga. 3. Proceni kolateralna cirkulacija na MSCT koronarnoj angiografiji pre i nakon fizičkog treninga. Materijal i metode: Naša studija je obuhvatila 32 bolesnika sa hroničnom stabilnom anginom pektoris refraktornom na optimalnu medikamentnu terapiju, koji nisu kandidati za perkutanu i/ili hiruršku revaskularizaciju (tzv. ''no-option” bolesnici). Kao drugi kriterijum za uključenje u studiju bolesnici su morali biti sposobni da vežbaju. Ovi pacijenti su se u periodu od 2013. do 2019. godine lečili na Klinici za kardiologiju Kliničkog Centra Srbije. Bolesnici su bili randomizovani u 2 grupe (po 16 bolesnika u svakoj grupi). Grupa 1 (placebo+vežbanje, P+E), bolesnici koji su podvrgnuti standardnoj fizikalnoj rehabilitaciji (iv. Placebo 10 minuta pre svake od 2 dnevne sesije fizičkog treninga koji se održava 5 dana nedeljno tokom 2 nedelje). Kao placebo injekciju koristili smo intravensku injekciju od 2 ml sa fiziološkim rastvorem (0,9% NaCl). Grupa 2 (heparin+vežbanje, H+E), bolesnici koji su bili podvrgnuti standardnoj fizikalnoj rehabilitaciji sa prethodnom primenom leka (isto kao prethodna grupa ali sa heparinom 100 ij/kg do maksimalne doze od 5000 ij iv. 10 minuta pre fizičkog treninga)...

Advisors/Committee Members: Đorđević-Dikić, Ana, 1964-, 12655975.

Subjects/Keywords: coronary arteriogenesis; heparin + exercise; stress echocardiographic test

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Petrović, Marija T., 1980-, 5. (2020). Značaj primene kombinovane terapije heparina i vežbanja kod bolesnika sa refraktornom anginom pektoris. (Thesis). Univerzitet u Beogradu. Retrieved from https://fedorabg.bg.ac.rs/fedora/get/o:22834/bdef:Content/get

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Petrović, Marija T., 1980-, 59182345. “Značaj primene kombinovane terapije heparina i vežbanja kod bolesnika sa refraktornom anginom pektoris.” 2020. Thesis, Univerzitet u Beogradu. Accessed March 04, 2021. https://fedorabg.bg.ac.rs/fedora/get/o:22834/bdef:Content/get.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Petrović, Marija T., 1980-, 59182345. “Značaj primene kombinovane terapije heparina i vežbanja kod bolesnika sa refraktornom anginom pektoris.” 2020. Web. 04 Mar 2021.

Vancouver:

Petrović, Marija T., 1980- 5. Značaj primene kombinovane terapije heparina i vežbanja kod bolesnika sa refraktornom anginom pektoris. [Internet] [Thesis]. Univerzitet u Beogradu; 2020. [cited 2021 Mar 04]. Available from: https://fedorabg.bg.ac.rs/fedora/get/o:22834/bdef:Content/get.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Petrović, Marija T., 1980- 5. Značaj primene kombinovane terapije heparina i vežbanja kod bolesnika sa refraktornom anginom pektoris. [Thesis]. Univerzitet u Beogradu; 2020. Available from: https://fedorabg.bg.ac.rs/fedora/get/o:22834/bdef:Content/get

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

30. Roam, Jacob. Growth Factor Gradient Formation and Release from PEG Microspheres for Nerve Regeneration.

Degree: PhD, Biomedical Engineering, 2015, Washington University in St. Louis

URL: https://openscholarship.wustl.edu/eng_etds/116

► Many biological processes depend on concentration gradients in signaling molecules. Thus, introduction of spatial patterning of proteins, while retaining activity and releasability, will be… (more)

▼ Many biological processes depend on concentration gradients in signaling molecules. Thus, introduction of spatial patterning of proteins, while retaining activity and releasability, will be critical for the field of regenerative medicine. In particular, the area of nerve regeneration is in need of innovations to improve outcomes. Only about 25% of surgical patients with peripheral nerve damage (~200,000 surgical interventions performed each year) regain full motor function with less than 3% regaining sensation. The use of nerve guidance conduits (NGC’s) which are filled with biomimetic scaffolds is one treatment being explored. These scaffolds, however, lack the spatial patterning of proteins found in native tissue. Glial-cell line derived neurotrophic factor (GDNF), a potent stimulator of axon regeneration, is one such protein that, if contained within the scaffold and conformed to a particular concentration profile, could greatly enhance neural regeneration. The object of this work is to utilize poly(ethylene glycol) (PEG) microspheres to accomplish this spatial patterning of GDNF and apply it to NGC’s. First, an approach utilizing the controllability of the PEG microsphere’s density (buoyancy) was explored. By creating the microspheres under varying conditions, incubation time and temperature, the cross-linking and, thus, the swelling rate of the microspheres could be controlled. This created microspheres of different densities that, upon centrifugation, would orient themselves within a scaffold, creating a gradient in the different microsphere types. GDNF loaded into a batch of microspheres would thusly be oriented within the scaffold along with that particular microsphere batch. Through this, gradients in GDNF were created. Heparin was also added to the microspheres to allow for reversible binding of GDNF. Next, gradients in reversibly bound GDNF were formed through sequential centrifugation of microsphere batches. For instance, a layer of GDNF loaded microspheres were formed into a scaffold followed by a layer of microspheres without GDNF on top of them. This created an initial step gradient in GDNF that, given time to release, would form a linear concentration gradient. Gradients formed by this method were visualized by fluorescent confocal microscopy and compared to Fickian models. Some conditions yielded profiles more linear than the model predictions, which persisted for over a week. Lastly, the sequential gradient formation was modified and applied to NGC’s. Before the scaffolds were ready for in vivo implantation, functionalities such as cell initiated degradability, cell adhesion, and inter-microsphere cross-linking were added. A plasmin degradable peptide sequence (GCGGVRNGGK) was incorporated into the microspheres. CLICK agents, laminin, and heparin (via a new binding chemistry) were attached to the microspheres to add inter-microsphere cross-linking, add cell adhesion, and heparin binding functionalities, respectively. GDNF gradient formation and activity retention were confirmed… Advisors/Committee Members: Donald L Elbert, Shelly Sakiyama-Elbert, Matthew Wood, Dennis Barbour, Jin-Yu Shao.

Subjects/Keywords: degradable; GDNF; gradient; heparin; NGC; PEG; Engineering

11 more images…

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Roam, J. (2015). Growth Factor Gradient Formation and Release from PEG Microspheres for Nerve Regeneration. (Doctoral Dissertation). Washington University in St. Louis. Retrieved from https://openscholarship.wustl.edu/eng_etds/116

Chicago Manual of Style (16^th Edition):

Roam, Jacob. “Growth Factor Gradient Formation and Release from PEG Microspheres for Nerve Regeneration.” 2015. Doctoral Dissertation, Washington University in St. Louis. Accessed March 04, 2021. https://openscholarship.wustl.edu/eng_etds/116.

MLA Handbook (7^th Edition):

Roam, Jacob. “Growth Factor Gradient Formation and Release from PEG Microspheres for Nerve Regeneration.” 2015. Web. 04 Mar 2021.

Vancouver:

Roam J. Growth Factor Gradient Formation and Release from PEG Microspheres for Nerve Regeneration. [Internet] [Doctoral dissertation]. Washington University in St. Louis; 2015. [cited 2021 Mar 04]. Available from: https://openscholarship.wustl.edu/eng_etds/116.

Council of Science Editors:

Roam J. Growth Factor Gradient Formation and Release from PEG Microspheres for Nerve Regeneration. [Doctoral Dissertation]. Washington University in St. Louis; 2015. Available from: https://openscholarship.wustl.edu/eng_etds/116

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Open Access Theses and Dissertations