subject:(Hemolysis)

McMaster University

1. Shareefdeen, Hiba. SYNERGISTIC HEMOLYSIS IN “NON-HEMOLYTIC” BACTEROIDES SPECIES.

Degree: MSc, 2020, McMaster University

►

Bacteroides is a genus of anaerobic bacteria that are often found in high abundance in the human colon. They have a complex relationship with their… (more)

Subjects/Keywords: Bacteroides; Hemolysis

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APA (6^th Edition):

Shareefdeen, H. (2020). SYNERGISTIC HEMOLYSIS IN “NON-HEMOLYTIC” BACTEROIDES SPECIES. (Masters Thesis). McMaster University. Retrieved from http://hdl.handle.net/11375/25399

Chicago Manual of Style (16^th Edition):

Shareefdeen, Hiba. “SYNERGISTIC HEMOLYSIS IN “NON-HEMOLYTIC” BACTEROIDES SPECIES.” 2020. Masters Thesis, McMaster University. Accessed January 15, 2021. http://hdl.handle.net/11375/25399.

MLA Handbook (7^th Edition):

Shareefdeen, Hiba. “SYNERGISTIC HEMOLYSIS IN “NON-HEMOLYTIC” BACTEROIDES SPECIES.” 2020. Web. 15 Jan 2021.

Vancouver:

Shareefdeen H. SYNERGISTIC HEMOLYSIS IN “NON-HEMOLYTIC” BACTEROIDES SPECIES. [Internet] [Masters thesis]. McMaster University; 2020. [cited 2021 Jan 15]. Available from: http://hdl.handle.net/11375/25399.

Council of Science Editors:

Shareefdeen H. SYNERGISTIC HEMOLYSIS IN “NON-HEMOLYTIC” BACTEROIDES SPECIES. [Masters Thesis]. McMaster University; 2020. Available from: http://hdl.handle.net/11375/25399

University of Louisville

2. Mohaghegh Faghih, Mohammad. Improving flow-induced hemolysis prediction models.

Degree: PhD, 2019, University of Louisville

URL: 10.18297/etd/3284 ; https://ir.library.louisville.edu/etd/3284

► Partial or complete failure of red blood cell membrane, also known as hemolysis, is a persistent issue with almost all blood contacting devices. Many… (more)

▼ Partial or complete failure of red blood cell membrane, also known as hemolysis, is a persistent issue with almost all blood contacting devices. Many experimental and theoretical contributions over the last few decades have increased insight into the mechanisms of mechanical hemolysis in both laminar and turbulent flow regimes, with the ultimate goal of developing a comprehensive, mechanistic and universal hemolysis prediction model. My research is broadly divided into two sections: theoretical/analytical/Computational Fluid Dynamics (CFD) analyses and experimental tests. The first part of my research revolved entirely around analyzing the simplest and most popular hemolysis model, commonly called as the power-law model. This model was developed only for laminar pure shear flow within a limited range of exposure time. Subsequently, modified versions of this model have been developed to be used for more complex flows. Many of these modified models assume that hemolysis scales with a resultant, scalar stress representing all components of the fluid stress tensor. The most common representative stress used in the power-law model is a von-Mises-like stress. However, using membrane tension models for pure shear and pure extension in both laminar and turbulent flows, for some simple example cases, we have shown that scalar stress alone is inadequate for scaling hemolysis. Alternatively, the rate of viscous energy dissipation rate has also been proposed as the parameter to scale hemolysis with. Applying the same order-of-magnitude estimate as vi mentioned above, we have found that dissipation rate even behaves worse than the resultant scalar stress for hemolysis prediction. It is therefore concluded that energy dissipation rate alone is also not sufficient to universally scale blood damage across complex flows. These show that a realistic model of hemolysis must take into account different responses of the viscoelastic cell membrane to different stress type. Various discretized version of the power-law model has also been introduced for post-processing of the CFD results. The power law can be either discretized in space, Eulerian treatment, or in time, Lagrangian treatment. Our study on the Eulerian approach revealed that the current equations used in the literature has a missing term, and thus incorrect. We also examined the mathematical stability of the discretized power-law model, and found that it may introduce significant error in red cell damage prediction for certain pathlines with specific stress history. Experimental results on deformation of red cell in pure shear flow is present for a relatively wide range of shear rates. However, red cell deformation/elongation in pure laminar extensional flow is scarce, with only one publication reporting their results on red cell deformation for only up to stress level of 10 Pa. For the experimental part of my research, we conducted experiments to observe the difference in deformation of red cell in pure shear and pure extensional flows, for stresses beyond what has already… Advisors/Committee Members: Sharp, M. Keith, Pantalos, George, Pantalos, George, Williams, Stuart, Rasipuram, Srinivasan.

Subjects/Keywords: hemolysis; prediction models; Mechanical Engineering

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APA (6^th Edition):

Mohaghegh Faghih, M. (2019). Improving flow-induced hemolysis prediction models. (Doctoral Dissertation). University of Louisville. Retrieved from 10.18297/etd/3284 ; https://ir.library.louisville.edu/etd/3284

Chicago Manual of Style (16^th Edition):

Mohaghegh Faghih, Mohammad. “Improving flow-induced hemolysis prediction models.” 2019. Doctoral Dissertation, University of Louisville. Accessed January 15, 2021. 10.18297/etd/3284 ; https://ir.library.louisville.edu/etd/3284.

MLA Handbook (7^th Edition):

Mohaghegh Faghih, Mohammad. “Improving flow-induced hemolysis prediction models.” 2019. Web. 15 Jan 2021.

Vancouver:

Mohaghegh Faghih M. Improving flow-induced hemolysis prediction models. [Internet] [Doctoral dissertation]. University of Louisville; 2019. [cited 2021 Jan 15]. Available from: 10.18297/etd/3284 ; https://ir.library.louisville.edu/etd/3284.

Council of Science Editors:

Mohaghegh Faghih M. Improving flow-induced hemolysis prediction models. [Doctoral Dissertation]. University of Louisville; 2019. Available from: 10.18297/etd/3284 ; https://ir.library.louisville.edu/etd/3284

Rochester Institute of Technology

3. Myagmar, Oyuna. Evaluation of CFD based hemolysis prediction methods.

Degree: Mechanical Engineering, 2011, Rochester Institute of Technology

URL: https://scholarworks.rit.edu/theses/5822

► Accurate quantitative evaluation of shear stress-related hemolysis (destruction of red blood cells) could be used to improve blood handling devices, including left ventricular assist… (more)

▼ Accurate quantitative evaluation of shear stress-related hemolysis (destruction of red blood cells) could be used to improve blood handling devices, including left ventricular assist devices (LVAD). Computational Fluid Dynamics (CFD) predicts the fluid dynamics of complex pump geometry and has been used to track the shear stress history of red blood cells as they travel through these devices. Several models that predict the relationship between hemolysis, shear stress and exposure time have been used to evaluate the hemolysis in the pumps. However, the prediction accuracy has not reached the satisfactory level. The goal of my thesis is to investigate the application of CFD in determining hemolysis using different hemolysis prediction methods. • This approach is two-fold. First it is done on a simplified geometry designed to produce known and controllable shear stresses. This device is known as the mag-lev shearing device and was designed using CFD in order to study erythrocyte damage in terms of the effects of shear stress. This mathematical solution for annular shearing device will be used to verify computational data. • Secondly, I applied the same methods to the LEV-VAD pump, currently under development at RIT. The grid independent mesh was obtained for RIT axial pump and was utilized for further studies. In Characteristic curve (Pressure vs. Flow), the experimental pressure rise data was compared with the pressure difference data from CFD simulation of the RIT mini pump. • Hemolysis was estimated for both geometries using four different hemolysis analysis methods, referred to as: Threshold Value, Mass-Weighted Average, Eulerian and Lagrangian approaches. The pump numerical hemolysis predictions are compared with the previous in vitro hemolysis data using bovine blood. The numerical simulation of flow field for mag-lev shearing device was compared with the analytical solution of the fluid dynamics inside the gap regions of the device. In the future, the mag-lev shearing device will be used with animal and human blood to empirically evaluate the hemolysis and this empirical data may be used to validate the numerical methods presented here. Advisors/Committee Members: Day, Steven.

Subjects/Keywords: Blood; CFD; Heart pump; Hemolysis; LVAD; Simulation

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APA (6^th Edition):

Myagmar, O. (2011). Evaluation of CFD based hemolysis prediction methods. (Thesis). Rochester Institute of Technology. Retrieved from https://scholarworks.rit.edu/theses/5822

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Myagmar, Oyuna. “Evaluation of CFD based hemolysis prediction methods.” 2011. Thesis, Rochester Institute of Technology. Accessed January 15, 2021. https://scholarworks.rit.edu/theses/5822.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Myagmar, Oyuna. “Evaluation of CFD based hemolysis prediction methods.” 2011. Web. 15 Jan 2021.

Vancouver:

Myagmar O. Evaluation of CFD based hemolysis prediction methods. [Internet] [Thesis]. Rochester Institute of Technology; 2011. [cited 2021 Jan 15]. Available from: https://scholarworks.rit.edu/theses/5822.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Myagmar O. Evaluation of CFD based hemolysis prediction methods. [Thesis]. Rochester Institute of Technology; 2011. Available from: https://scholarworks.rit.edu/theses/5822

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Rochester Institute of Technology

4. Poskus, Matthew D. Numerical Model to Predict Hemolysis and Transport in a Membrane-Based Microfluidic Device.

Degree: MS, Mechanical Engineering, 2019, Rochester Institute of Technology

URL: https://scholarworks.rit.edu/theses/10301

► Microfluidics has become an increasingly popular tool in the design and development of medical devices and artificial organs. Two promising applications of microfluidics are… (more)

Subjects/Keywords: Computational; Dialysis; Hemolysis; Membrane; Numerical; Transport

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APA (6^th Edition):

Poskus, M. D. (2019). Numerical Model to Predict Hemolysis and Transport in a Membrane-Based Microfluidic Device. (Masters Thesis). Rochester Institute of Technology. Retrieved from https://scholarworks.rit.edu/theses/10301

Chicago Manual of Style (16^th Edition):

Poskus, Matthew D. “Numerical Model to Predict Hemolysis and Transport in a Membrane-Based Microfluidic Device.” 2019. Masters Thesis, Rochester Institute of Technology. Accessed January 15, 2021. https://scholarworks.rit.edu/theses/10301.

MLA Handbook (7^th Edition):

Poskus, Matthew D. “Numerical Model to Predict Hemolysis and Transport in a Membrane-Based Microfluidic Device.” 2019. Web. 15 Jan 2021.

Vancouver:

Poskus MD. Numerical Model to Predict Hemolysis and Transport in a Membrane-Based Microfluidic Device. [Internet] [Masters thesis]. Rochester Institute of Technology; 2019. [cited 2021 Jan 15]. Available from: https://scholarworks.rit.edu/theses/10301.

Council of Science Editors:

Poskus MD. Numerical Model to Predict Hemolysis and Transport in a Membrane-Based Microfluidic Device. [Masters Thesis]. Rochester Institute of Technology; 2019. Available from: https://scholarworks.rit.edu/theses/10301

5. Mulenga, James. The microbiological causes of chronic osteomyelitis at the University Teaching Hospital,Lusaka.

Degree: 2017, University of Zimbabwe

URL: http://dspace.unza.zm/handle/123456789/5058

► BACKGROUND: Chronic osteomyelitis is a debilitating infection of bone and its bone marrow, presenting with bone pain and an active sinus that discharges pus. It… (more)

Subjects/Keywords: Osteomyelitis; Staphylococcus; Hemolysis and Hemolysins; Bones-Diseases

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APA (6^th Edition):

Mulenga, J. (2017). The microbiological causes of chronic osteomyelitis at the University Teaching Hospital,Lusaka. (Thesis). University of Zimbabwe. Retrieved from http://dspace.unza.zm/handle/123456789/5058

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Mulenga, James. “The microbiological causes of chronic osteomyelitis at the University Teaching Hospital,Lusaka.” 2017. Thesis, University of Zimbabwe. Accessed January 15, 2021. http://dspace.unza.zm/handle/123456789/5058.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Mulenga, James. “The microbiological causes of chronic osteomyelitis at the University Teaching Hospital,Lusaka.” 2017. Web. 15 Jan 2021.

Vancouver:

Mulenga J. The microbiological causes of chronic osteomyelitis at the University Teaching Hospital,Lusaka. [Internet] [Thesis]. University of Zimbabwe; 2017. [cited 2021 Jan 15]. Available from: http://dspace.unza.zm/handle/123456789/5058.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Mulenga J. The microbiological causes of chronic osteomyelitis at the University Teaching Hospital,Lusaka. [Thesis]. University of Zimbabwe; 2017. Available from: http://dspace.unza.zm/handle/123456789/5058

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Virginia Tech

6. Walters, Jessica Nicole. Characterization of Atypical Hemolytic Ornithobacterium rhinotracheale Isolates and Comparison with the Normal Non-Hemolytic Phenotype.

Degree: PhD, Veterinary Medical Sciences, 2014, Virginia Tech

URL: http://hdl.handle.net/10919/77251

► Ornithobacterium rhinotracheale (ORT) is a Gram-negative bacterium that causes respiratory disease in poultry characterized by rhinitis, tracheitis, and pneumonia with mortality averaging 2-3%. In the… (more)

▼ Ornithobacterium rhinotracheale (ORT) is a Gram-negative bacterium that causes respiratory disease in poultry characterized by rhinitis, tracheitis, and pneumonia with mortality averaging 2-3%. In the Shenandoah Valley of Virginia, the seroprevalence for ORT among turkey flocks as determined by enzyme-linked immunosorbent assay (ELISA) was found to be 70.9% (n=175). Additionally, the seroprevalence for hemorrhagic enteritis virus (vaccine induced), Bordetella avium, and paramyxovirus-1 was 100%, 74.8%, and 6.3% respectively. No significant interactions were detected. The type strain of ORT is characteristically non-hemolytic at least for 96 hours at 37°C on Columbia Blood Agar. In recent years, atypical isolates that rapidly produce hemolysis have been isolated with increasing frequency. A variety of in vitro tests were used to determine differences between representative isolates of the hemolytic (H) and non-hemolytic (NH) phenotypes. Findings suggest that the H isolate contains a 4 kb plasmid similar to that found in Reimerella anatipestifer. No plasmid was found in the NH isolate. Differences in growth characteristics and resistance to tetracyclines were also noted. No differences in proteins, biochemical characteristics or 16S rRNA sequences were found, the latter serving as confirmation that the isolates were both ORT. Embryo inoculation was used to assess virulence. No significant differences were observed and most embryos survived through to the day of hatch (pip) despite the fact that ORT could be re-isolated. In turkey poults however, the H phenotype did appear less virulent. A significant depression in weight gain was noted for birds inoculated intratracheally with the NH isolate at 7 days post-inoculation (dpi). NH inoculates also had significantly higher antibody levels on ELISA at 14 and 21 dpi and histopathological lesion scores for lung at 7, 14, and 21 dpi. The NH isolate could be re-isolated from NH-inoculated poults through 21 dpi; whereas the H isolate could only be re-isolated through 14 dpi. In conclusion, there are numerous differences between the NH and H isolates found in the field with the H isolate appearing less virulent and as such, making it a potential vaccine candidate. The phenotypic difference appears to correlate with this, but may not suffice to explain it. Advisors/Committee Members: Pierson, Frank William (committeechair), McElroy, Audrey (committee member), Evans, Robert (committee member), Sriranganathan, Nammalwar (committee member), LeRoith, Tanya (committee member).

Subjects/Keywords: Ornithobacterium rhinotracheale; hemolysis; ELISA; plasmid; turkeys

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APA (6^th Edition):

Walters, J. N. (2014). Characterization of Atypical Hemolytic Ornithobacterium rhinotracheale Isolates and Comparison with the Normal Non-Hemolytic Phenotype. (Doctoral Dissertation). Virginia Tech. Retrieved from http://hdl.handle.net/10919/77251

Chicago Manual of Style (16^th Edition):

Walters, Jessica Nicole. “Characterization of Atypical Hemolytic Ornithobacterium rhinotracheale Isolates and Comparison with the Normal Non-Hemolytic Phenotype.” 2014. Doctoral Dissertation, Virginia Tech. Accessed January 15, 2021. http://hdl.handle.net/10919/77251.

MLA Handbook (7^th Edition):

Walters, Jessica Nicole. “Characterization of Atypical Hemolytic Ornithobacterium rhinotracheale Isolates and Comparison with the Normal Non-Hemolytic Phenotype.” 2014. Web. 15 Jan 2021.

Vancouver:

Walters JN. Characterization of Atypical Hemolytic Ornithobacterium rhinotracheale Isolates and Comparison with the Normal Non-Hemolytic Phenotype. [Internet] [Doctoral dissertation]. Virginia Tech; 2014. [cited 2021 Jan 15]. Available from: http://hdl.handle.net/10919/77251.

Council of Science Editors:

Walters JN. Characterization of Atypical Hemolytic Ornithobacterium rhinotracheale Isolates and Comparison with the Normal Non-Hemolytic Phenotype. [Doctoral Dissertation]. Virginia Tech; 2014. Available from: http://hdl.handle.net/10919/77251

7. Juliane Almeida Moreira. Impacto dos haplÃtipos do gene ΒS sobre os marcadores de hemÃlise em pacientes com anemia falciforme em estado basal.

Degree: Master, 2013, Universidade Federal do Ceará

URL: http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=12359 ;

► A anemia falciforme (AF) Ã uma doenÃa hereditÃria resultante de uma mutaÃÃo pontual (GAG  GTG) no cÃdon do gene da βS - globina, levando… (more)

▼ A anemia falciforme (AF) Ã uma doenÃa hereditÃria resultante de uma mutaÃÃo pontual (GAG  GTG) no cÃdon do gene da βS - globina, levando a uma substituiÃÃo de Ãcido glutÃmico por valina na sexta posiÃÃo da cadeia polipeptÃdica, gerando uma hemoglobina (Hb) anormal denominada de HbS, em homozigose. A AF se caracteriza por anemia hemolÃtica crÃnica associada a mÃltiplos eventos tais como processo inflamatÃrio crÃnico, aumento do estresse oxidativo, dano endotelial, diminuiÃÃo da biodisponibilidade do Ãxido nÃtrico (NO), ativaÃÃo da coagulaÃÃo, dentre outros. Os biomarcadores de hemÃlise tais como: contagem de reticulÃcitos, lactato desidrogenase (LDH), Ãcido Ãrico e arginase I sÃo fundamentais na avaliaÃÃo do grau da hemÃlise, principalmente, de natureza intravascular contribuindo com o monitoramento da anemia nesses pacientes. O presente estudo teve como objetivo avaliar o impacto dos haplÃtipos do gene βS sobre os marcadores de hemÃlise em adultos com AF em estado basal, acompanhados no ambulatÃrio do serviÃo de hematologia no Hospital UniversitÃrio Walter CantÃdio (HUWC). Um total de 50 pacientes adultos com AF foi selecionado, com diagnÃstico confirmado por estudo molecular. Os pacientes se encontravam em uso de hidroxiurÃia (HU), dose variando de 500 mg a 1,5 g/kg/dia por no mÃnimo seis meses. Um grupo controle foi elaborado, sendo constituÃdo por 20 indivÃduos supostamente saudÃveis. Foram coletados 10 mL de sangue venoso em tubo de coleta a vÃcuo, contendo o anticoagulante EDTA (etileno-diamino-tetracÃtico), para a realizaÃÃo da contagem de reticulÃcitos e 6 mL de sangue venoso em tubo de coleta a vÃcuo contendo gel separador, sem anticoagulante, para as dosagens sÃricas de LDH , Ãcido Ãrico e arginase I. As variÃveis idade, sexo, dosagem e tempo de uso do medicamento, concentraÃÃo da Hb e da hemoglobina fetal (HbF) foram obtidas nos prontuÃrios mÃdicos no momento da realizaÃÃo do estudo. As anÃlises estatÃsticas foram realizadas no programa GraphPad Prism (versÃo 5.0) e o nÃvel de significÃncia estabelecido foi p < 0,05. Foi verificado aumento significante nos nÃveis de reticulÃcitos, LDH, Ãcido Ãrico e arginase I nos pacientes com AF em relaÃÃo ao grupo controle (p < 0,05). Foi observada diferenÃa significativa na Hb nos grupos Bantu/Benin em relaÃÃo aos demais haplÃtipos do cluster da βs-globina. Os nÃveis de HbF apresentaram uma tendÃncia a aumento no haplÃtipo Benin/Benin em relaÃÃo aos demais. Foi verificada uma tendÃncia no aumento de LDH no genÃtipo Bantu/Bantu em comparaÃÃo com os demais haplÃtipos. Foi observada diferenÃa significativa da arginase I entre os grupos Bantu/Bantu vs Bantu/Benin e Bantu/Bantu vs Benin/Benin. Os resultados do presente estudo reforÃam a hipÃtese de que a arginase I possa ser utilizada como possÃvel indicador de gravidade uma vez que a mesma foi associada ao haplÃtipo Bantu. Advisors/Committee Members: RomÃlia Pinheiro GonÃalves Lemes, JosÃ Ajax Nogueira Queiroz, Maria da Silva Pitombeira, Herivaldo Ferreira da Silva.

Subjects/Keywords: HEMATOLOGIA; Anemia Falciforme; Haplotipos; HemÃlise; Sickle cell anemia; Haplotypes; Hemolysis

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APA (6^th Edition):

Moreira, J. A. (2013). Impacto dos haplÃtipos do gene ΒS sobre os marcadores de hemÃlise em pacientes com anemia falciforme em estado basal. (Masters Thesis). Universidade Federal do Ceará. Retrieved from http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=12359 ;

Chicago Manual of Style (16^th Edition):

Moreira, Juliane Almeida. “Impacto dos haplÃtipos do gene ΒS sobre os marcadores de hemÃlise em pacientes com anemia falciforme em estado basal.” 2013. Masters Thesis, Universidade Federal do Ceará. Accessed January 15, 2021. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=12359 ;.

MLA Handbook (7^th Edition):

Moreira, Juliane Almeida. “Impacto dos haplÃtipos do gene ΒS sobre os marcadores de hemÃlise em pacientes com anemia falciforme em estado basal.” 2013. Web. 15 Jan 2021.

Vancouver:

Moreira JA. Impacto dos haplÃtipos do gene ΒS sobre os marcadores de hemÃlise em pacientes com anemia falciforme em estado basal. [Internet] [Masters thesis]. Universidade Federal do Ceará 2013. [cited 2021 Jan 15]. Available from: http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=12359 ;.

Council of Science Editors:

Moreira JA. Impacto dos haplÃtipos do gene ΒS sobre os marcadores de hemÃlise em pacientes com anemia falciforme em estado basal. [Masters Thesis]. Universidade Federal do Ceará 2013. Available from: http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=12359 ;

Mississippi State University

8. Mohammadi-Aragh, Maryam Kate. Evaluation of urea hydrolysis as a biomarker for detecting pathogenic Vibrio parahaemolyticus in clinical isolates and raw oysters.

Degree: MS, Food Science, Nutrition, and Health Promotion, 2016, Mississippi State University

URL: http://sun.library.msstate.edu/ETD-db/theses/available/etd-10212016-105706/ ;

► Vibrio parahaemolyticus (Vp) infection is commonly caused by the consumption of raw or undercooked shellfish. Raw oysters are associated with most Vp outbreaks. Pathogenic… (more)

Subjects/Keywords: hemolysis; trh; tdh; urease; food safety; Vibrio parahaemolyticus

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APA (6^th Edition):

Mohammadi-Aragh, M. K. (2016). Evaluation of urea hydrolysis as a biomarker for detecting pathogenic Vibrio parahaemolyticus in clinical isolates and raw oysters. (Masters Thesis). Mississippi State University. Retrieved from http://sun.library.msstate.edu/ETD-db/theses/available/etd-10212016-105706/ ;

Chicago Manual of Style (16^th Edition):

Mohammadi-Aragh, Maryam Kate. “Evaluation of urea hydrolysis as a biomarker for detecting pathogenic Vibrio parahaemolyticus in clinical isolates and raw oysters.” 2016. Masters Thesis, Mississippi State University. Accessed January 15, 2021. http://sun.library.msstate.edu/ETD-db/theses/available/etd-10212016-105706/ ;.

MLA Handbook (7^th Edition):

Mohammadi-Aragh, Maryam Kate. “Evaluation of urea hydrolysis as a biomarker for detecting pathogenic Vibrio parahaemolyticus in clinical isolates and raw oysters.” 2016. Web. 15 Jan 2021.

Vancouver:

Mohammadi-Aragh MK. Evaluation of urea hydrolysis as a biomarker for detecting pathogenic Vibrio parahaemolyticus in clinical isolates and raw oysters. [Internet] [Masters thesis]. Mississippi State University; 2016. [cited 2021 Jan 15]. Available from: http://sun.library.msstate.edu/ETD-db/theses/available/etd-10212016-105706/ ;.

Council of Science Editors:

Mohammadi-Aragh MK. Evaluation of urea hydrolysis as a biomarker for detecting pathogenic Vibrio parahaemolyticus in clinical isolates and raw oysters. [Masters Thesis]. Mississippi State University; 2016. Available from: http://sun.library.msstate.edu/ETD-db/theses/available/etd-10212016-105706/ ;

Rochester Institute of Technology

9. Revankar, Shanoo. Computational Fluid Dynamics based redesign of the Magnetically Levitated Blood Shearing Device for Hemolysis Predictions.

Degree: MS, Mechanical Engineering, 2013, Rochester Institute of Technology

URL: https://scholarworks.rit.edu/theses/6634

► Annular Couette type blood shearing devices have been used for analysis of blood damage related to device induced shear stress. Two important factors in… (more)

Subjects/Keywords: Fluid dynamics – Mathematics; Blood – Circulation; Artificial; Hemolysis and hemolysins

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APA (6^th Edition):

Revankar, S. (2013). Computational Fluid Dynamics based redesign of the Magnetically Levitated Blood Shearing Device for Hemolysis Predictions. (Masters Thesis). Rochester Institute of Technology. Retrieved from https://scholarworks.rit.edu/theses/6634

Chicago Manual of Style (16^th Edition):

Revankar, Shanoo. “Computational Fluid Dynamics based redesign of the Magnetically Levitated Blood Shearing Device for Hemolysis Predictions.” 2013. Masters Thesis, Rochester Institute of Technology. Accessed January 15, 2021. https://scholarworks.rit.edu/theses/6634.

MLA Handbook (7^th Edition):

Revankar, Shanoo. “Computational Fluid Dynamics based redesign of the Magnetically Levitated Blood Shearing Device for Hemolysis Predictions.” 2013. Web. 15 Jan 2021.

Vancouver:

Revankar S. Computational Fluid Dynamics based redesign of the Magnetically Levitated Blood Shearing Device for Hemolysis Predictions. [Internet] [Masters thesis]. Rochester Institute of Technology; 2013. [cited 2021 Jan 15]. Available from: https://scholarworks.rit.edu/theses/6634.

Council of Science Editors:

Revankar S. Computational Fluid Dynamics based redesign of the Magnetically Levitated Blood Shearing Device for Hemolysis Predictions. [Masters Thesis]. Rochester Institute of Technology; 2013. Available from: https://scholarworks.rit.edu/theses/6634

Aristotle University Of Thessaloniki (AUTH); Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης (ΑΠΘ)

10. Ntelios, Dimitrios. Μελέτη της έκφρασης των microRNA σε ασθενείς με υπερτροφική μυοκαρδιοπάθεια.

Degree: 2019, Aristotle University Of Thessaloniki (AUTH); Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης (ΑΠΘ)

URL: http://hdl.handle.net/10442/hedi/45877

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microRNAs (miRNAs) are small noncoding RNAs with a crucial role in the post-transcriptional regulation of gene expression. Several studies have shown that miRNAs are involved… (more)

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microRNAs (miRNAs) are small noncoding RNAs with a crucial role in the post-transcriptional regulation of gene expression. Several studies have shown that miRNAs are involved in the pathogenesis of cardiovascular diseases. Therefore, the potential use of miRNAs as biomarkers or targets for new therapies for a variety of cardiovascular diseases are areas of tremendous interest. The aim of this study was to measure plasma levels of miR-146a, miR-29a, miR-181c, miR-199a, miR-208a και miR-208b in patients with hypertrophic cardiomyopathy and normal controls and to correlate possible alterations in plasma miRNA levels with certain clinical and laboratory data from those patients. miR-146a-5p levels were analyzed in plasma samples from 50 patients with hypertrophic cardiomyopathy and 30 controls using Real time qPCR and specific TaqMan assays. Relative quantitation was performed using the 2-ΔΔCt method. The results of this study have shown that plasma levels of miR-146a was increased in patients with hypertrophic cardiomyopathy. Additionally, plasma levels of miR-146a correlate significantly with the presence of left ventricle outflow tract obstruction. The case of miR-29a underscores that hemolysis is a factor that could lead to pre-analytical errors in miRNA determination in plasma.

Τα microRNAs (miRNA) αποτελούν μικρά μη κωδικά μόρια RNA με σημαντικό ρόλο στη ρύθμιση της γονιδιακής έκφρασης σε μετα-μεταγραφικό επίπεδο. Πρόσφατα δεδομένα αναδεικνύουν ότι τα miRNAs εμπλέκονται στην παθογένεση αρκετών νοσημάτων του καρδιαγγειακού συστήματος. Στα πλαίσια αυτά υπάρχει έντονο ερευνητικό ενδιαφέρον για την πιθανή μελλοντική χρήση τους ως βιοδεικτών ή νέων θεραπευτικών στόχων. Σκοπός της παρούσας μελέτης ήταν να διερευνήσει τις μεταβολές στα επίπεδα των miR-146a, miR-29a, miR-181c, miR-199a, miR-208a και miR-208b στο πλάσμα ασθενών με υπερτροφική μυοκαρδιοπάθεια σε σχέση με υγιείς καθώς και να διερευνήσει την ύπαρξη συσχετίσεων μεταξύ των μεταβολών αυτών με κλινικά και εργαστηριακά δεδομένα. Στη μελέτη συμπεριελήφθησαν 50 ασθενείς με υπερτροφική μυοκαρδιοπάθεια καθώς και 30 υγιείς μάρτυρες. H μέτρηση των επιπέδων των miRNA έγινε με αλυσιδωτή αντίδραση πολυμεράσης πραγματικού χρόνου με τη χρήση ειδικών ιχνηθετών Taqman. Για τη σχετική ποσοτικοποίηση ακολουθήθηκε η μέθοδος 2-ΔΔCt. Τα αποτελέσματα της μελέτης αυτής έδειξαν ότι οι ασθενείς με υπερτροφική μυοκαρδιοπάθεια παρουσιάζουν αύξηση των επιπέδων του miR-146a και μάλιστα η αύξηση αυτή σχετίζεται με την παρουσία απόφραξης στο χώρο εξόδου της αριστερής κοιλίας. Τέλος η μελέτη του miR-29a αναδεικνύει ότι η ύπαρξη αιμόλυσης αποτελεί ένα σημαντικό παράγοντα που μπορεί να επηρεάσει τη μέτρηση των επιπέδων των miRNA στο πλάσμα και να οδηγήσει σε εσφαλμένα αποτελέσματα.

Subjects/Keywords: Υπερτροφική μυοκαρδιοπάθεια; miRNAs; Αιμόλυση; Hypertrophic cardiomyopathy; miRNA; Hemolysis

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APA (6^th Edition):

Ntelios, D. (2019). Μελέτη της έκφρασης των microRNA σε ασθενείς με υπερτροφική μυοκαρδιοπάθεια. (Thesis). Aristotle University Of Thessaloniki (AUTH); Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης (ΑΠΘ). Retrieved from http://hdl.handle.net/10442/hedi/45877

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Ntelios, Dimitrios. “Μελέτη της έκφρασης των microRNA σε ασθενείς με υπερτροφική μυοκαρδιοπάθεια.” 2019. Thesis, Aristotle University Of Thessaloniki (AUTH); Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης (ΑΠΘ). Accessed January 15, 2021. http://hdl.handle.net/10442/hedi/45877.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Ntelios, Dimitrios. “Μελέτη της έκφρασης των microRNA σε ασθενείς με υπερτροφική μυοκαρδιοπάθεια.” 2019. Web. 15 Jan 2021.

Vancouver:

Ntelios D. Μελέτη της έκφρασης των microRNA σε ασθενείς με υπερτροφική μυοκαρδιοπάθεια. [Internet] [Thesis]. Aristotle University Of Thessaloniki (AUTH); Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης (ΑΠΘ); 2019. [cited 2021 Jan 15]. Available from: http://hdl.handle.net/10442/hedi/45877.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Ntelios D. Μελέτη της έκφρασης των microRNA σε ασθενείς με υπερτροφική μυοκαρδιοπάθεια. [Thesis]. Aristotle University Of Thessaloniki (AUTH); Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης (ΑΠΘ); 2019. Available from: http://hdl.handle.net/10442/hedi/45877

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

11. Lee, Ya-Jung. Delivery of proteins in live cells with viral peptides: principles and mechanisms.

Degree: PhD, Biochemistry, 2012, Texas A&M University

URL: http://hdl.handle.net/1969.1/ETD-TAMU-2011-05-9270

► Cell-penetrating peptides (CPPs) mediate the delivery of macromolecules across the plasma membrane of live cells. These peptides are therefore important due to the potential of… (more)

Subjects/Keywords: HA2; TAT; hemolysis; mCherry

…42 2.4.6 Hemolysis assays… …Heparin inhibits membrane binding of E5-TAT and hemolysis .......... 92 Discussion… …104 4.4.2 Hemolysis assays… …63 4-1 Hemolysis activities ofHA2 and HA2-TAT analogues as a function of pH…

10 more images…

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APA (6^th Edition):

Lee, Y. (2012). Delivery of proteins in live cells with viral peptides: principles and mechanisms. (Doctoral Dissertation). Texas A&M University. Retrieved from http://hdl.handle.net/1969.1/ETD-TAMU-2011-05-9270

Chicago Manual of Style (16^th Edition):

Lee, Ya-Jung. “Delivery of proteins in live cells with viral peptides: principles and mechanisms.” 2012. Doctoral Dissertation, Texas A&M University. Accessed January 15, 2021. http://hdl.handle.net/1969.1/ETD-TAMU-2011-05-9270.

MLA Handbook (7^th Edition):

Lee, Ya-Jung. “Delivery of proteins in live cells with viral peptides: principles and mechanisms.” 2012. Web. 15 Jan 2021.

Vancouver:

Lee Y. Delivery of proteins in live cells with viral peptides: principles and mechanisms. [Internet] [Doctoral dissertation]. Texas A&M University; 2012. [cited 2021 Jan 15]. Available from: http://hdl.handle.net/1969.1/ETD-TAMU-2011-05-9270.

Council of Science Editors:

Lee Y. Delivery of proteins in live cells with viral peptides: principles and mechanisms. [Doctoral Dissertation]. Texas A&M University; 2012. Available from: http://hdl.handle.net/1969.1/ETD-TAMU-2011-05-9270

University of Adelaide

12. Keen, Thomas Edward Baldwin. The haemolysins of Chironex fleckeri and Chiropsalmus quadrigatus.

Degree: 1972, University of Adelaide

URL: http://hdl.handle.net/2440/116452

Subjects/Keywords: Jellyfishes; Hemolysis and hemolysins

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Keen, T. E. B. (1972). The haemolysins of Chironex fleckeri and Chiropsalmus quadrigatus. (Thesis). University of Adelaide. Retrieved from http://hdl.handle.net/2440/116452

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Keen, Thomas Edward Baldwin. “The haemolysins of Chironex fleckeri and Chiropsalmus quadrigatus.” 1972. Thesis, University of Adelaide. Accessed January 15, 2021. http://hdl.handle.net/2440/116452.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Keen, Thomas Edward Baldwin. “The haemolysins of Chironex fleckeri and Chiropsalmus quadrigatus.” 1972. Web. 15 Jan 2021.

Vancouver:

Keen TEB. The haemolysins of Chironex fleckeri and Chiropsalmus quadrigatus. [Internet] [Thesis]. University of Adelaide; 1972. [cited 2021 Jan 15]. Available from: http://hdl.handle.net/2440/116452.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Keen TEB. The haemolysins of Chironex fleckeri and Chiropsalmus quadrigatus. [Thesis]. University of Adelaide; 1972. Available from: http://hdl.handle.net/2440/116452

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Toronto

13. Lin, Wei-Chih Patrick. Cavopulmonary Assist Device to Bridge Failing Fontan Circulations.

Degree: 2018, University of Toronto

URL: http://hdl.handle.net/1807/89608

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A novel cavopulmonary assist strategy with a multi-lumen cannula powered by an external centrifugal pump is proposed for use in failing Fontan patients. Steady-state computational… (more)

Subjects/Keywords: Cavopulmonary Assist; Computational Fluid Dynamics (CFD); Fontan; Hemolysis Index; 0541

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APA (6^th Edition):

Lin, W. P. (2018). Cavopulmonary Assist Device to Bridge Failing Fontan Circulations. (Masters Thesis). University of Toronto. Retrieved from http://hdl.handle.net/1807/89608

Chicago Manual of Style (16^th Edition):

Lin, Wei-Chih Patrick. “Cavopulmonary Assist Device to Bridge Failing Fontan Circulations.” 2018. Masters Thesis, University of Toronto. Accessed January 15, 2021. http://hdl.handle.net/1807/89608.

MLA Handbook (7^th Edition):

Lin, Wei-Chih Patrick. “Cavopulmonary Assist Device to Bridge Failing Fontan Circulations.” 2018. Web. 15 Jan 2021.

Vancouver:

Lin WP. Cavopulmonary Assist Device to Bridge Failing Fontan Circulations. [Internet] [Masters thesis]. University of Toronto; 2018. [cited 2021 Jan 15]. Available from: http://hdl.handle.net/1807/89608.

Council of Science Editors:

Lin WP. Cavopulmonary Assist Device to Bridge Failing Fontan Circulations. [Masters Thesis]. University of Toronto; 2018. Available from: http://hdl.handle.net/1807/89608

14. Manaargadoo-Catin, Magalie. Etude des interactions entre les cellules sanguines et les tensioactifs : Study of the interactions between surfactants and red blood cells.

Degree: Docteur es, Ingénierie moléculaire, 2015, Montpellier

URL: http://www.theses.fr/2015MONTS029

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En hématologie, des tensioactifs tels que les saponines sont utilisés comme agent érythrolytique afin de compter et identifier les différentes populations de globules blancs, qui… (more)

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En hématologie, des tensioactifs tels que les saponines sont utilisés comme agent érythrolytique afin de compter et identifier les différentes populations de globules blancs, qui sont mille fois moins abondants que les érythrocytes. Ces saponines sont utilisées pour leur lyse sélective des globules rouges dans les réactifs d’HORIBA Médical. Au cours de cette thèse, nous avons étudié l’action de différents tensioactifs sur les cellules sanguines afin d’avoir une meilleure compréhension des interactions tensioactifs/membrane. Le premier projet a porté sur l’observation et la caractérisation des effets des saponines sur les érythrocytes par des méthodes microscopiques et spectrophotométriques, dans le but d’obtenir une meilleure compréhension de leur sélectivité vis-à-vis des globules rouges. Nous avons ainsi démontré la participation du cholestérol, des transporteurs tels que la bande 3 et du cytosquelette lors de la lyse par les saponines. Dans une seconde étude, des recherches ont été entreprises afin d’identifier les propriétés requises d’un tensioactif pour obtenir un agent lytique efficace. Nous avons sélectionné deux types de familles de tensioactifs, l’une non-ionique de type éther d’alcool polyoxyéthylèné, et l’autre anionique à base d’acides aminés. Ces études se sont concentrées sur la relation entre le pouvoir érythrolytique et certains paramètres physico-chimiques des tensioactifs tels que la concentration micellaire critique (CMC), la balance hydrophile-lipophile (HLB), le coefficient de partage entre la membrane et le milieu aqueux (Kb), et le packing parameter (P). Nous avons montré qu’une considération globale de l’ensemble de ces paramètres était nécessaire pour pouvoir prédire les interactions des tensioactifs avec la membrane des érythrocytes. Enfin, l’effet lytique de ces tensioactifs sur les leucocytes a été étudié en cytométrie en flux afin de vérifier l’intégrité des globules blancs lors des différentes lyses. Les résultats obtenus au cours de ces travaux de thèse rendent possible le développement de futurs réactifs hématologiques pour la différenciation leucocytaire.

Surfactants such as saponins are employed, in the haematology field, as erythrolytic agent in order to count and to identify different leukocyte populations, which are typically thousand times less abundant than erythrocytes. These saponins are used for erythrocytes selective lysis in HORIBA Medical reagents. This thesis aimed to study the action of different surfactants on red blood cells in order to have a better understanding of surfactants/membrane interactions. The first project involved the observation and the characterization of saponins effects on erythrocytes by microscopic and spectrophotometric methods, in order to understand saponins selectivity regarding erythrocytes. We have thus demonstrated the participation of cholesterol, transporters such as band 3 and erythrocyte cytoskeleton during saponins lysis. In a second study, investigations have been performed in order to identify surfactants properties required to get…

Advisors/Committee Members: Perrin, Catherine (thesis director).

Subjects/Keywords: Tensioactifs; Hémolyse; Érythrocytes; Interactions; Surfactants; Hemolysis; Erythrocyte; Interactions

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APA (6^th Edition):

Manaargadoo-Catin, M. (2015). Etude des interactions entre les cellules sanguines et les tensioactifs : Study of the interactions between surfactants and red blood cells. (Doctoral Dissertation). Montpellier. Retrieved from http://www.theses.fr/2015MONTS029

Chicago Manual of Style (16^th Edition):

Manaargadoo-Catin, Magalie. “Etude des interactions entre les cellules sanguines et les tensioactifs : Study of the interactions between surfactants and red blood cells.” 2015. Doctoral Dissertation, Montpellier. Accessed January 15, 2021. http://www.theses.fr/2015MONTS029.

MLA Handbook (7^th Edition):

Manaargadoo-Catin, Magalie. “Etude des interactions entre les cellules sanguines et les tensioactifs : Study of the interactions between surfactants and red blood cells.” 2015. Web. 15 Jan 2021.

Vancouver:

Manaargadoo-Catin M. Etude des interactions entre les cellules sanguines et les tensioactifs : Study of the interactions between surfactants and red blood cells. [Internet] [Doctoral dissertation]. Montpellier; 2015. [cited 2021 Jan 15]. Available from: http://www.theses.fr/2015MONTS029.

Council of Science Editors:

Manaargadoo-Catin M. Etude des interactions entre les cellules sanguines et les tensioactifs : Study of the interactions between surfactants and red blood cells. [Doctoral Dissertation]. Montpellier; 2015. Available from: http://www.theses.fr/2015MONTS029

University of California – San Francisco

15. Poirot, Eugenie Aude Marguerite. Evaluating the safety of malaria treatment in glucose-6-phosphate dehydrogenase-deficient individuals: evidence and tools to support malaria elimination.

Degree: Epidemiology and Translational Science, 2016, University of California – San Francisco

URL: http://www.escholarship.org/uc/item/21n0v4rj

► There have been remarkable achievements in the global fight against malaria over the past decade, with a growing number of countries moving towards malaria elimination.… (more)

▼ There have been remarkable achievements in the global fight against malaria over the past decade, with a growing number of countries moving towards malaria elimination. Sustaining these gains and eliminating malaria will require the right set of interventions and strategies that target the entire Plasmodium falciparum (P. falciparum) parasite reservoir, including both the mosquito vector and the human host. Primaquine is the only available drug that clears mature P. falciparum gametocytes in humans, thereby preventing transmission to the mosquito vector. However, the drug’s oxidative capacity to cause hemolytic effects in individuals with glucose-6-phosphate dehydrogenase (G6PD) deficiency, has limited its deployment because of safety concerns. G6PD deficiency is an X-linked enzyme defect that affects over 400 million people worldwide and is relatively common in malaria endemic areas. To reduce P. falciparum malaria transmission in eliminating settings and areas threatened by artemisinin resistance, the World Health Organization (WHO) recommends adding a 0.25 mg/kg dose of primaquine, lowered from a previously higher 0.75 mg/kg dose, to standard artemisinin-based combination therapy (ACT) without G6PD testing. This policy change, issued in 2012, was based on data gathered passively from limited pharmacovigilance systems and lacks substantive evidence to support the safety of the recommendation. The objective of this dissertation was to evaluate the safety of malaria treatment in G6PD-deficient individuals and contribute evidence to support the programmatic use of primaquine for falciparum malaria. The study designs and populations presented in this dissertation include: 1) a secondary analysis of data from a double-blind, placebo-controlled trial of preventive antimalarial treatment in asymptomatic infants (n = 1557) in Tanzania (Chapter 1); 2) a pilot study evaluating a pharmacovigilance safety monitoring tool for the rollout of single low-dose primaquine among confirmed, uncomplicated malaria cases (n = 102) in Swaziland (Chapter 2); and 3) a pooled analysis of individual-level patient data in malaria-infected patients (n = 604) from two randomized controlled trials in Senegal and Tanzania and two active pharmacovigilance programs in Bangladesh and Swaziland (Chapter 3). In the trial of asymptomatic infants in Tanzania, findings demonstrated that treatment with an antimalarial drug known to have oxidative potential like primaquine reduced hemoglobin levels at 7 and 14 days post-treatment, relative to placebo and other antimalarial treatments. Also, at day 7, G6PD deficiency was associated with higher odds of moderate anemia (hemoglobin <8 g/dL) and greater absolute reductions in hemoglobin. However, there was no evidence that G6PD deficiency exacerbated the adverse effects of oxidative treatment. Measuring the risk of adverse effects in G6PD-deficient individuals associated with oxidative treatment is challenging due to limited data.The pilot study of the Primaquine Roll Out Monitoring Pharmacovigilance Tool…

Subjects/Keywords: Epidemiology; Glucose-6-phosphate dehydrogenase deficiency; Hemolysis; Malaria; Plasmodium falciparum; Primaquine

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APA (6^th Edition):

Poirot, E. A. M. (2016). Evaluating the safety of malaria treatment in glucose-6-phosphate dehydrogenase-deficient individuals: evidence and tools to support malaria elimination. (Thesis). University of California – San Francisco. Retrieved from http://www.escholarship.org/uc/item/21n0v4rj

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Poirot, Eugenie Aude Marguerite. “Evaluating the safety of malaria treatment in glucose-6-phosphate dehydrogenase-deficient individuals: evidence and tools to support malaria elimination.” 2016. Thesis, University of California – San Francisco. Accessed January 15, 2021. http://www.escholarship.org/uc/item/21n0v4rj.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Poirot, Eugenie Aude Marguerite. “Evaluating the safety of malaria treatment in glucose-6-phosphate dehydrogenase-deficient individuals: evidence and tools to support malaria elimination.” 2016. Web. 15 Jan 2021.

Vancouver:

Poirot EAM. Evaluating the safety of malaria treatment in glucose-6-phosphate dehydrogenase-deficient individuals: evidence and tools to support malaria elimination. [Internet] [Thesis]. University of California – San Francisco; 2016. [cited 2021 Jan 15]. Available from: http://www.escholarship.org/uc/item/21n0v4rj.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Poirot EAM. Evaluating the safety of malaria treatment in glucose-6-phosphate dehydrogenase-deficient individuals: evidence and tools to support malaria elimination. [Thesis]. University of California – San Francisco; 2016. Available from: http://www.escholarship.org/uc/item/21n0v4rj

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Michigan State University

16. Jen, Chauying Jack. Studies on the hemolysis kinetics of human erythrocytes by using a stop flow system.

Degree: MS, Department of Mechanical Engineering, 1980, Michigan State University

URL: http://etd.lib.msu.edu/islandora/object/etd:40686

Subjects/Keywords: Hemolysis and hemolysins; Erythrocytes

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APA (6^th Edition):

Jen, C. J. (1980). Studies on the hemolysis kinetics of human erythrocytes by using a stop flow system. (Masters Thesis). Michigan State University. Retrieved from http://etd.lib.msu.edu/islandora/object/etd:40686

Chicago Manual of Style (16^th Edition):

Jen, Chauying Jack. “Studies on the hemolysis kinetics of human erythrocytes by using a stop flow system.” 1980. Masters Thesis, Michigan State University. Accessed January 15, 2021. http://etd.lib.msu.edu/islandora/object/etd:40686.

MLA Handbook (7^th Edition):

Jen, Chauying Jack. “Studies on the hemolysis kinetics of human erythrocytes by using a stop flow system.” 1980. Web. 15 Jan 2021.

Vancouver:

Jen CJ. Studies on the hemolysis kinetics of human erythrocytes by using a stop flow system. [Internet] [Masters thesis]. Michigan State University; 1980. [cited 2021 Jan 15]. Available from: http://etd.lib.msu.edu/islandora/object/etd:40686.

Council of Science Editors:

Jen CJ. Studies on the hemolysis kinetics of human erythrocytes by using a stop flow system. [Masters Thesis]. Michigan State University; 1980. Available from: http://etd.lib.msu.edu/islandora/object/etd:40686

17. Jain, Jagrati. Biochemical and Molecular Assessment of Toxicity of Primaquine Metabolites on Erythrocytes.

Degree: PhD, Biomolecular Sciences, 2017, University of Mississippi

URL: https://egrove.olemiss.edu/etd/1480

► The 8-aminoquinoline (8AQ) antimalarial drug primaquine (PQ) is the only drug for prevention of malaria relapse. Moreover, PQ also has gametocytocidal activity against Plasmodium falciparum.… (more)

▼ The 8-aminoquinoline (8AQ) antimalarial drug primaquine (PQ) is the only drug for prevention of malaria relapse. Moreover, PQ also has gametocytocidal activity against Plasmodium falciparum. However, clinical use of PQ has been limited due to its hemolytic toxicity, especially in glucose-6-phosphate dehydrogenase deficient (G6PDd) individuals. Phenolic and quinone metabolites generated via cytochrome P450-dependent pathways appear to be responsible for hemolytic effects of PQ. However, the mechanism for the hemolytic toxicity of PQ is still poorly understood. To explore the mechanism, targets, and pathways for toxicity of PQ, normal and G6PDd human erythrocytes were treated with the potential hemotoxic metabolites of PQ namely, 5-hydroxy-primaquine (5-HPQ), 5,6-orthoquinone primaquine (5,6-OQPQ) and 6-methoxy-8-hydroxylaminoquinoline (MHQ). The early and late biomarkers of hemotoxicity were investigated to explore the mechanism of PQ toxicity. 5HPQ, 5,6-OQPQ, and MHQ caused marked increase in methemoglobin formation and generated robust oxidative stress in both normal and G6PDd human erythrocytes. However, these metabolites depleted reduce glutathione (GSH) levels selectively in G6PDd human erythrocytes. Treatment with 5,6-OQPQ also induced eryptosis in G6PDd erythrocytes, as determined by phosphatidylserine exposure (Annexin V binding). This study was further extended to investigate the role of NRH-quinone oxidoreductase 2 (NQO2) in PQ-induced hemolytic toxicity. NQO2, has a potential function in metabolic detoxification or activation of quinones and quinone-based drugs. Co-treatment of erythrocytes with NQO2 inhibitors potentiated the hemotoxic response of PQ metabolites. The computational docking studies suggested stronger interactions of PQ metabolites with NQO2 compared to melatonin (the NQO2 inhibitor) and menadione (the NQO2 substrate). Together these results suggest that NQO2 might have a protective role against PQ-induced hemolytic toxicity. The PQ metabolite, 5,6-OQPQ was further evaluated for the effects on the non-targeted global metabolomic profile of normal and G6PDd human erythrocytes. The GSH-methionine-glutamate pathway metabolites were greatly affected by G6PD deficiency. Treatment with 5,6-OQPQ also significantly modified GSH-methionine-glutamic acid pathway in erythrocytes. Treatment also increased the levels of antioxidant and hemolysis related markers in erythrocytes. These studies provide a better insight into the pathophysiology of hemolytic toxicity caused by PQ in the G6PDd population.The new knowledge generated would provide rational bases for controlling toxicity of PQ and designing 8AQ analogs with better safety and therapeutic profiles. Advisors/Committee Members: Babu L Tekwani, Larry A. Walker, John M. Rimoldi.

Subjects/Keywords: Hemolysis; Metabolites; Metabolomics; NQO2; Primaquine; Toxicity; Molecular Biology

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Jain, J. (2017). Biochemical and Molecular Assessment of Toxicity of Primaquine Metabolites on Erythrocytes. (Doctoral Dissertation). University of Mississippi. Retrieved from https://egrove.olemiss.edu/etd/1480

Chicago Manual of Style (16^th Edition):

Jain, Jagrati. “Biochemical and Molecular Assessment of Toxicity of Primaquine Metabolites on Erythrocytes.” 2017. Doctoral Dissertation, University of Mississippi. Accessed January 15, 2021. https://egrove.olemiss.edu/etd/1480.

MLA Handbook (7^th Edition):

Jain, Jagrati. “Biochemical and Molecular Assessment of Toxicity of Primaquine Metabolites on Erythrocytes.” 2017. Web. 15 Jan 2021.

Vancouver:

Jain J. Biochemical and Molecular Assessment of Toxicity of Primaquine Metabolites on Erythrocytes. [Internet] [Doctoral dissertation]. University of Mississippi; 2017. [cited 2021 Jan 15]. Available from: https://egrove.olemiss.edu/etd/1480.

Council of Science Editors:

Jain J. Biochemical and Molecular Assessment of Toxicity of Primaquine Metabolites on Erythrocytes. [Doctoral Dissertation]. University of Mississippi; 2017. Available from: https://egrove.olemiss.edu/etd/1480

University of Missouri – Columbia

18. Hanson, Marina McCoy, 1984-. Intermedilysin-mediated cell ablation in the rat and zebrafish.

Degree: 2016, University of Missouri – Columbia

URL: https://doi.org/10.32469/10355/59849

► Current methodologies of cell ablation have limitations with respect to the types of cells that can be targeted, the lack of specificity of ablation and… (more)

Subjects/Keywords: Streptolysin; Cell-mediated cytotoxicity; Hemolysis and hemolysins; Animal models in research

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APA (6^th Edition):

Hanson, Marina McCoy, 1. (2016). Intermedilysin-mediated cell ablation in the rat and zebrafish. (Thesis). University of Missouri – Columbia. Retrieved from https://doi.org/10.32469/10355/59849

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Hanson, Marina McCoy, 1984-. “Intermedilysin-mediated cell ablation in the rat and zebrafish.” 2016. Thesis, University of Missouri – Columbia. Accessed January 15, 2021. https://doi.org/10.32469/10355/59849.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Hanson, Marina McCoy, 1984-. “Intermedilysin-mediated cell ablation in the rat and zebrafish.” 2016. Web. 15 Jan 2021.

Vancouver:

Hanson, Marina McCoy 1. Intermedilysin-mediated cell ablation in the rat and zebrafish. [Internet] [Thesis]. University of Missouri – Columbia; 2016. [cited 2021 Jan 15]. Available from: https://doi.org/10.32469/10355/59849.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Hanson, Marina McCoy 1. Intermedilysin-mediated cell ablation in the rat and zebrafish. [Thesis]. University of Missouri – Columbia; 2016. Available from: https://doi.org/10.32469/10355/59849

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

19. Gallagher, Tara. Comparison of the antibacterial, colloidal, and hemolytic properties of novel triple-headed, triscationic amphiphiles.

Degree: 2015, James Madison University

URL: https://commons.lib.jmu.edu/master201019/46

► Antibiotic resistant bacteria were first reported in the 1940s, several years after the clinical introduction of penicillin. Since then, antibiotic resistance has contributed to increasing… (more)

Subjects/Keywords: amphiphile; surfactant; antibacterial; micelle; synergy; hemolysis; Other Microbiology

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APA (6^th Edition):

Gallagher, T. (2015). Comparison of the antibacterial, colloidal, and hemolytic properties of novel triple-headed, triscationic amphiphiles. (Masters Thesis). James Madison University. Retrieved from https://commons.lib.jmu.edu/master201019/46

Chicago Manual of Style (16^th Edition):

Gallagher, Tara. “Comparison of the antibacterial, colloidal, and hemolytic properties of novel triple-headed, triscationic amphiphiles.” 2015. Masters Thesis, James Madison University. Accessed January 15, 2021. https://commons.lib.jmu.edu/master201019/46.

MLA Handbook (7^th Edition):

Gallagher, Tara. “Comparison of the antibacterial, colloidal, and hemolytic properties of novel triple-headed, triscationic amphiphiles.” 2015. Web. 15 Jan 2021.

Vancouver:

Gallagher T. Comparison of the antibacterial, colloidal, and hemolytic properties of novel triple-headed, triscationic amphiphiles. [Internet] [Masters thesis]. James Madison University; 2015. [cited 2021 Jan 15]. Available from: https://commons.lib.jmu.edu/master201019/46.

Council of Science Editors:

Gallagher T. Comparison of the antibacterial, colloidal, and hemolytic properties of novel triple-headed, triscationic amphiphiles. [Masters Thesis]. James Madison University; 2015. Available from: https://commons.lib.jmu.edu/master201019/46

University of Louisville

20. Chen, Yangsheng, 1969-. Analysis and experiments on flow-induced hemolysis.

Degree: PhD, 2006, University of Louisville

URL: 10.18297/etd/236 ; https://ir.library.louisville.edu/etd/236

► Hemolysis (red cells lysis) caused by fluid stresses in flows within hypodermic needles, blood pumps, artificial hearts and other cardiovascular devices, is one of the… (more)

▼ Hemolysis (red cells lysis) caused by fluid stresses in flows within hypodermic needles, blood pumps, artificial hearts and other cardiovascular devices, is one of the major concerns during the design and use of cardiovascular or blood-processing extracorporeal devices. A non-invasive experimental method which does not interfere directly with red blood cells was designed to investigate the red cells' deformations in response to a range of flow conditions. The designed flow chamber and pump system provided a controlled two-dimensional Poiseuille flow with average velocity of up to 4 m/s and a range of fluid stresses up to 5000 dyn/cm 2 . The dimension of deformed cells and positions was measured to obtain the aspect ratio of red cells under stress from images captured by the microscope-laser-camera system. A strain-based blood damage model from Rand's viscoelastic model was built to predict cell strain. The empirical coefficients in the blood damage model were calibrated by the measurements from the experiments. Flow-induced hemolysis in the blood flow through hypodermic needles was investigated. The flow-induced hemolysis of the needles may be reduced by a modified design of the entrance geometry of the needle. Three groups of 16 gauge needles were compared: one standard group with sharp entrance, another with beveled entrance and a third with rounded entrance. The CFD analysis combined with the strain-based blood damage model, Heuser et al. model and Giersiepen et al. model respectively was used to analyze the flow-induced hemolysis of the three needles. The predicted results were compared to the experimental results, which showed the rounded entrance reduced hemolysis by 34%, but the beveled entrance increased hemolysis by 38%. The strain-based blood damage model predicted the reduced hemolysis by 7.4% in rounded needle and the increased hemolysis by 13% in beveled needle. Both Heuser et al. model and Giersiepen et al. model predicted increased hemolysis in rounded needle. Advisors/Committee Members: Sharp, Michael Keith.

Subjects/Keywords: Hemolysis; Hypodermic needles; Blood flow

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APA (6^th Edition):

Chen, Yangsheng, 1. (2006). Analysis and experiments on flow-induced hemolysis. (Doctoral Dissertation). University of Louisville. Retrieved from 10.18297/etd/236 ; https://ir.library.louisville.edu/etd/236

Chicago Manual of Style (16^th Edition):

Chen, Yangsheng, 1969-. “Analysis and experiments on flow-induced hemolysis.” 2006. Doctoral Dissertation, University of Louisville. Accessed January 15, 2021. 10.18297/etd/236 ; https://ir.library.louisville.edu/etd/236.

MLA Handbook (7^th Edition):

Chen, Yangsheng, 1969-. “Analysis and experiments on flow-induced hemolysis.” 2006. Web. 15 Jan 2021.

Vancouver:

Chen, Yangsheng 1. Analysis and experiments on flow-induced hemolysis. [Internet] [Doctoral dissertation]. University of Louisville; 2006. [cited 2021 Jan 15]. Available from: 10.18297/etd/236 ; https://ir.library.louisville.edu/etd/236.

Council of Science Editors:

Chen, Yangsheng 1. Analysis and experiments on flow-induced hemolysis. [Doctoral Dissertation]. University of Louisville; 2006. Available from: 10.18297/etd/236 ; https://ir.library.louisville.edu/etd/236

The Ohio State University

21. Mezick, James Andrew. Studies on the mechanism of hemolysis induced by menadione .

Degree: PhD, Graduate School, 1969, The Ohio State University

URL: http://rave.ohiolink.edu/etdc/view?acc_num=osu1486653137101259

Subjects/Keywords: Chemistry; Hemolysis and hemolysins

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APA (6^th Edition):

Mezick, J. A. (1969). Studies on the mechanism of hemolysis induced by menadione . (Doctoral Dissertation). The Ohio State University. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=osu1486653137101259

Chicago Manual of Style (16^th Edition):

Mezick, James Andrew. “Studies on the mechanism of hemolysis induced by menadione .” 1969. Doctoral Dissertation, The Ohio State University. Accessed January 15, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=osu1486653137101259.

MLA Handbook (7^th Edition):

Mezick, James Andrew. “Studies on the mechanism of hemolysis induced by menadione .” 1969. Web. 15 Jan 2021.

Vancouver:

Mezick JA. Studies on the mechanism of hemolysis induced by menadione . [Internet] [Doctoral dissertation]. The Ohio State University; 1969. [cited 2021 Jan 15]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=osu1486653137101259.

Council of Science Editors:

Mezick JA. Studies on the mechanism of hemolysis induced by menadione . [Doctoral Dissertation]. The Ohio State University; 1969. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=osu1486653137101259

The Ohio State University

22. Haque, Riaz-ul. Purification and properties of Staphylococcal Beta Hemolysin .

Degree: PhD, Graduate School, 1963, The Ohio State University

URL: http://rave.ohiolink.edu/etdc/view?acc_num=osu1486551575624271

Subjects/Keywords: Biology; Staphylococcus; Hemolysis and hemolysins

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APA (6^th Edition):

Haque, R. (1963). Purification and properties of Staphylococcal Beta Hemolysin . (Doctoral Dissertation). The Ohio State University. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=osu1486551575624271

Chicago Manual of Style (16^th Edition):

Haque, Riaz-ul. “Purification and properties of Staphylococcal Beta Hemolysin .” 1963. Doctoral Dissertation, The Ohio State University. Accessed January 15, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=osu1486551575624271.

MLA Handbook (7^th Edition):

Haque, Riaz-ul. “Purification and properties of Staphylococcal Beta Hemolysin .” 1963. Web. 15 Jan 2021.

Vancouver:

Haque R. Purification and properties of Staphylococcal Beta Hemolysin . [Internet] [Doctoral dissertation]. The Ohio State University; 1963. [cited 2021 Jan 15]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=osu1486551575624271.

Council of Science Editors:

Haque R. Purification and properties of Staphylococcal Beta Hemolysin . [Doctoral Dissertation]. The Ohio State University; 1963. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=osu1486551575624271

Michigan State University

23. Mayer, Mary Louise. Studies on the serological relationships, fermentation reactions, and dissociation patterns of Pasteurella hemolytica isolated from chickens.

Degree: MS, 1953, Michigan State University

URL: http://etd.lib.msu.edu/islandora/object/etd:12014

Subjects/Keywords: Poultry – Diseases; Hemolysis and hemolysins

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APA (6^th Edition):

Mayer, M. L. (1953). Studies on the serological relationships, fermentation reactions, and dissociation patterns of Pasteurella hemolytica isolated from chickens. (Masters Thesis). Michigan State University. Retrieved from http://etd.lib.msu.edu/islandora/object/etd:12014

Chicago Manual of Style (16^th Edition):

Mayer, Mary Louise. “Studies on the serological relationships, fermentation reactions, and dissociation patterns of Pasteurella hemolytica isolated from chickens.” 1953. Masters Thesis, Michigan State University. Accessed January 15, 2021. http://etd.lib.msu.edu/islandora/object/etd:12014.

MLA Handbook (7^th Edition):

Mayer, Mary Louise. “Studies on the serological relationships, fermentation reactions, and dissociation patterns of Pasteurella hemolytica isolated from chickens.” 1953. Web. 15 Jan 2021.

Vancouver:

Mayer ML. Studies on the serological relationships, fermentation reactions, and dissociation patterns of Pasteurella hemolytica isolated from chickens. [Internet] [Masters thesis]. Michigan State University; 1953. [cited 2021 Jan 15]. Available from: http://etd.lib.msu.edu/islandora/object/etd:12014.

Council of Science Editors:

Mayer ML. Studies on the serological relationships, fermentation reactions, and dissociation patterns of Pasteurella hemolytica isolated from chickens. [Masters Thesis]. Michigan State University; 1953. Available from: http://etd.lib.msu.edu/islandora/object/etd:12014

Michigan State University

24. Yao, Dorothy Tao-Lien. The effect of the surface active agent Pluronic F-68 on red blood cell hemolysis in vitro and during cardiopulmonary bypass.

Degree: MS, Dept. of Pathology, 1972, Michigan State University

URL: http://etd.lib.msu.edu/islandora/object/etd:15315

Subjects/Keywords: Hemolysis and hemolysins; Erythrocytes

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APA (6^th Edition):

Yao, D. T. (1972). The effect of the surface active agent Pluronic F-68 on red blood cell hemolysis in vitro and during cardiopulmonary bypass. (Masters Thesis). Michigan State University. Retrieved from http://etd.lib.msu.edu/islandora/object/etd:15315

Chicago Manual of Style (16^th Edition):

Yao, Dorothy Tao-Lien. “The effect of the surface active agent Pluronic F-68 on red blood cell hemolysis in vitro and during cardiopulmonary bypass.” 1972. Masters Thesis, Michigan State University. Accessed January 15, 2021. http://etd.lib.msu.edu/islandora/object/etd:15315.

MLA Handbook (7^th Edition):

Yao, Dorothy Tao-Lien. “The effect of the surface active agent Pluronic F-68 on red blood cell hemolysis in vitro and during cardiopulmonary bypass.” 1972. Web. 15 Jan 2021.

Vancouver:

Yao DT. The effect of the surface active agent Pluronic F-68 on red blood cell hemolysis in vitro and during cardiopulmonary bypass. [Internet] [Masters thesis]. Michigan State University; 1972. [cited 2021 Jan 15]. Available from: http://etd.lib.msu.edu/islandora/object/etd:15315.

Council of Science Editors:

Yao DT. The effect of the surface active agent Pluronic F-68 on red blood cell hemolysis in vitro and during cardiopulmonary bypass. [Masters Thesis]. Michigan State University; 1972. Available from: http://etd.lib.msu.edu/islandora/object/etd:15315

25. MarÃlia Rocha Laurentino. Relationship between gene polymorphisms at BCL11A and hemolysis markers in patients with sickle cell disease.

Degree: Master, 2016, Universidade Federal do Ceará

URL: http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=16437 ;

►

Sickle cell disease (SCD) is a hematological disease caused by a point mutation in the β-globin gene. Sickle hemoglobin (HbS) is generated due to fragile… (more)

▼

Sickle cell disease (SCD) is a hematological disease caused by a point mutation in the β-globin gene. Sickle hemoglobin (HbS) is generated due to fragile mutation that decreases the red blood cell lifetime due to its chronic destruction, being the main responsible for the signs and symptoms of the disease. The use of hydroxyurea (HU) and genetic polymorphisms on modulates fetal hemoglobin (HbF), the main inhibitor of HbS polymerization, reducing hemolysis and vaso-occlusion. This study aimed to evaluate the association of polymorphisms BCL11A gene on the hemolysis markers reticulocytes, bilirubin, uric acid, lactate dehydrogenase (LDH) and methemoglobin (MetHb). The study included 45 patients with SCD of both sexes, in use of HU, attended in outpatient University Hospital Walter CantÃdio (HUWC) in Fortaleza, CearÃ, and 80 healthy individuals as a control group. The MetHb, uric acid and bilirubin dosage has performed by spectrophotometric method, the LDH by a kinetic method, the reticulocyte count by manual method and evaluation of BCL11A polymorphisms by PCR in real time. Data were analyzed using the statistical software GraphPad Prism. The level of significance was set at <5%. Patients with SCD and healthy subjects showed a difference between hematological parameters, hemoglobin, hematocrit, mean corpuscular volume (MCV) and platelets. Regarding the hemolysis parameters, it was observed that SCD patients has an increase of reticulocytes, MetHb, LDH and bilirubins compared to control group. The rs7557939 region showed an association with hemolysis biomarkers MetHb and LDH and rs4671393 region with the HbS concentration. The use of HU at doses higher than 10 mg/kg/day and for a longer period than 50 months had association with the decrease of the LDH concentration and the reticulocyte count. We conclude that polymorphisms on BCL11A gene and treatment with HU may modulate the hemolysis biomarkers, however, more research is necessary to study prognostic indicators and the factors involved in the clinical heterogeneity of SCD.

A anemia falciforme (AF) Ã uma doenÃa hematolÃgica causada por uma mutaÃÃo pontual no gene da β-globina. A hemoglobina S (HbS) gerada devido Ã mutaÃÃo forma hemÃcias com menor meia-vida devido Ã sua destruiÃÃo crÃnica, sendo a principal responsÃvel pelos sinais e sintomas da doenÃa. Os polimorfismos do gene BLC11A e o uso de hidroxiurÃia (HU) modulam a concentraÃÃo de hemoglobina fetal (HbF), principal inibidora da polimerizaÃÃo da HbS, diminuindo a hemÃlise e a vaso-oclusÃo. O presente estudo teve o objetivo de associar os polimorfismos do gene BCL11A com os biomarcadores de hemÃlise reticulÃcitos, bilirrubinas, Ãcido Ãrico, lactato desidrogenase (LDH), e metemoglobina (MetHb). Participaram do estudo 45 pacientes com AF em uso de HU, de ambos os sexos, atendidos no ambulatÃrio de Hematologia do Hospital UniversitÃrio Walter CantÃdio (HUWC) em Fortaleza-CearÃ e 80 indivÃduos saudÃveis como grupo controle. A dosagem de MetHb, de Ãcido Ãrico e bilirrubinas foi realizada atravÃs de mÃtodo…

Advisors/Committee Members: RomÃlia Pinheiro GonÃalves Lemes, Cristiane Cunha Frota, JosÃ Ajax Nogueira Queiroz, RosÃngela Pinheiro GonÃalves Machado.

Subjects/Keywords: HEMATOLOGIA; Anemia Falciforme; HemÃlise; Polimorfismo GenÃtico; Anemia, Sickle Cell; Hemolysis; Polymorphism, Genetic

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APA (6^th Edition):

Laurentino, M. R. (2016). Relationship between gene polymorphisms at BCL11A and hemolysis markers in patients with sickle cell disease. (Masters Thesis). Universidade Federal do Ceará. Retrieved from http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=16437 ;

Chicago Manual of Style (16^th Edition):

Laurentino, MarÃlia Rocha. “Relationship between gene polymorphisms at BCL11A and hemolysis markers in patients with sickle cell disease.” 2016. Masters Thesis, Universidade Federal do Ceará. Accessed January 15, 2021. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=16437 ;.

MLA Handbook (7^th Edition):

Laurentino, MarÃlia Rocha. “Relationship between gene polymorphisms at BCL11A and hemolysis markers in patients with sickle cell disease.” 2016. Web. 15 Jan 2021.

Vancouver:

Laurentino MR. Relationship between gene polymorphisms at BCL11A and hemolysis markers in patients with sickle cell disease. [Internet] [Masters thesis]. Universidade Federal do Ceará 2016. [cited 2021 Jan 15]. Available from: http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=16437 ;.

Council of Science Editors:

Laurentino MR. Relationship between gene polymorphisms at BCL11A and hemolysis markers in patients with sickle cell disease. [Masters Thesis]. Universidade Federal do Ceará 2016. Available from: http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=16437 ;

26. Gregorio Fernandes Goncalves. Avaliação das atividades citotóxica e genotóxica de Taninos de Mimosa arenosa (Willd.) Poir. (MIMOSACEAE).

Degree: 2011, Universidade Federal da Paraíba

URL: http://bdtd.biblioteca.ufpb.br/tde_busca/arquivo.php?codArquivo=1883

►

Natural products represent a rich source of biologically active compounds and are an example of molecular diversity, with recognized potential in the discovery and development… (more)

▼

Natural products represent a rich source of biologically active compounds and are an example of molecular diversity, with recognized potential in the discovery and development of new drugs The genus Mimosa is distributed in various environments and various types of vegetation in tropical regions. In northeast Brazil can be found in the state of Bahia, Pernambuco and Paraíba. Many species of Mimosa are economically important, however, few biological studies of plants of this kind were carried out so far, with proven antibacterial and allelopathic activity. Therefore, the objective of this study was to evaluate the cytotoxic and genotoxic activities of the species M. arenosa (Willd.) Poir. tannins. The minimum inhibitory concentration (MIC) obtained for Pseudomonas aeruginosa ATCC 8027 and Pseudomonas aeruginosa ATCC 25619 was 1000μg, for Bacillus subtilis ATCC 0516 and Escherichia coli ATCC 2536 MIC was 500μg, as to the strains of Staphylococcus aureus ATCC 6538, Staphylococcus aureus ATCC 25925 and Escherichia coli ATCC 10536 the amount of tannin required to inhibit the growth of these bacteria was 250μg. The antibacterial activity exerted by Mimosa arenosa tannins against all strains tested was bacteriostatic. In the evaluation of cytotoxicity in any of the tested concentrations of tannins M. arenosa no caused significant hemolysis of red cells in any of the blood groups tested. However, the tannins were unable to protect the erythrocyte cells when exposed to hypotonic salt solutions. The tannins were not affected in any of the oxidant concentrations tested but they have reduced the oxidation of hemoglobin when exposed to an oxidizing agent. The tannins were not able to induce mutations but showed antimutagenic effect in strains of S. thyphimurium. Tannins did not induce structural cromossomal damage and/or numerical in erythrocytes of mouse.

Os produtos naturais representam uma rica fonte de compostos biologicamente ativos e são um exemplo de diversidade molecular, com reconhecido potencial na descoberta e desenvolvimento de novos medicamentos. O gênero Mimosa se distribui nos mais variados ambientes e nos diversos tipos de vegetação das regiões tropicais. No nordeste do Brasil pode ser encontrado nos estados da Bahia, Pernambuco e Paraíba. Muitas espécies de Mimosa são economicamente importantes, no entanto, poucos estudos biológicos de plantas desse gênero foram realizados ate o momento, sendo comprovadas atividade antimicrobiana e alelopática. Sendo assim, o objetivo deste trabalho foi avaliar as atividades citotóxica e genotóxica de taninos da espécie Mimosa arenosa (Willd.) Poir. A concentração inibitória mínima (CIM) obtida para Pseudomonas aeruginosa ATCC 8027 e Pseudomonas aeruginosa ATCC 25619 foi 1000μg, para Bacillus subtilis ATCC 0516 e Escherichia coli ATCC 2536 a CIM foi de 500μg, já para as linhagens de Staphylococcus aureus ATCC 6538, Staphylococcus aureus ATCC 25925 e Escherichia coli ATCC 10536 a quantidade necessária de taninos para inibir o crescimento dessas…

Advisors/Committee Members: Hilzeth de Luna Freire Pessôa, Margareth de Fátima Formiga Melo Diniz.

Subjects/Keywords: micronúcleo; estresse oxidativo; hemólise; Mimosa arenosa; FARMACOLOGIA; Mimosa arenosa; hemolysis; oxidative stress; micronucleus assay

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APA (6^th Edition):

Goncalves, G. F. (2011). Avaliação das atividades citotóxica e genotóxica de Taninos de Mimosa arenosa (Willd.) Poir. (MIMOSACEAE). (Thesis). Universidade Federal da Paraíba. Retrieved from http://bdtd.biblioteca.ufpb.br/tde_busca/arquivo.php?codArquivo=1883

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Goncalves, Gregorio Fernandes. “Avaliação das atividades citotóxica e genotóxica de Taninos de Mimosa arenosa (Willd.) Poir. (MIMOSACEAE).” 2011. Thesis, Universidade Federal da Paraíba. Accessed January 15, 2021. http://bdtd.biblioteca.ufpb.br/tde_busca/arquivo.php?codArquivo=1883.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Goncalves, Gregorio Fernandes. “Avaliação das atividades citotóxica e genotóxica de Taninos de Mimosa arenosa (Willd.) Poir. (MIMOSACEAE).” 2011. Web. 15 Jan 2021.

Vancouver:

Goncalves GF. Avaliação das atividades citotóxica e genotóxica de Taninos de Mimosa arenosa (Willd.) Poir. (MIMOSACEAE). [Internet] [Thesis]. Universidade Federal da Paraíba; 2011. [cited 2021 Jan 15]. Available from: http://bdtd.biblioteca.ufpb.br/tde_busca/arquivo.php?codArquivo=1883.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Goncalves GF. Avaliação das atividades citotóxica e genotóxica de Taninos de Mimosa arenosa (Willd.) Poir. (MIMOSACEAE). [Thesis]. Universidade Federal da Paraíba; 2011. Available from: http://bdtd.biblioteca.ufpb.br/tde_busca/arquivo.php?codArquivo=1883

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universidade Estadual de Campinas

27. Souza, Danilo Santos, 1985. Caracterização e avaliação da capacidade antioxidante da polpa liofilizada enriquecida com extrato aquoso da semente de tamarindo (Tamarindus indica): Characterization and evaluation of the antioxidant capacity of freeze-dried pulp enriched with aqueous extract of tamarind (Tamarindus indica) seed.

Degree: 2015, Universidade Estadual de Campinas

URL: http://repositorio.unicamp.br/jspui/handle/REPOSIP/254306

► Abstract: The seed of tamarind, responsible for the most amount of bioactive compounds of the fruit, has only been marginally exploited for food purposes. The… (more)

▼ Abstract: The seed of tamarind, responsible for the most amount of bioactive compounds of the fruit, has only been marginally exploited for food purposes. The aim of the present study was to characterize the fruit (pulp and seeds) regarding their antioxidant properties as well as produce and characterize a lyophilized product made of pulp and aqueous extract of freeze-dried tamarind seed, taking advantage of the functional properties (antioxidant) and at the same time maintaining acceptable sensory characteristics. Tamarind fruits were acquired from three different states of Brazil (MG, SP e BA). The lots were obtained in 2012 and 2013. The fatty acid profile and tocopherols seeds were also evaluated. The best conditions for the extraction of bioactive compounds, from tamarind seed in aqueous phase, was set by Central Composite Rotational Design (CCRD). The best extraction condition consisted of: 80 s of trituration with a ratio (w/v) of 1:3 (seeds:water), were the residue material was extracted twice under the same conditions. The extracts were added to the pulps at the concentrations [1] (0.3%), [2] (1.15%) and [3] (2.0%), relative to the in natura hydrated pulp, to made the mixture (mix). The content of phenolic compounds (FT), antioxidant capacity (FRAP, DPPH, ABTS and ORAC) and hemolytic activity were determined for the pulps, seeds, freeze-dried seed extracts and freeze-dried mix of pulp and fruit seed extract. The results were dependent on the origin of the fruit. The pulp enrichment were satisfactory with substantial increase of the antioxidant capacity (ABTS?) by 1910, 1300 and 937% for mixtures of MG [3] SP [3] and BA [3], respectively. The samples acquired from São Paulo and Bahia had the highest rates of hemolysis, especially for those in which high amount of extract was added, reaching 98.8% of cell lysis for the SPsample [2] Lot 2, and 98.5% for the BA sample [1] lot 1. Ten fatty acids from the seed oil were identified and quantified by GC-FID technique, and 9 of them were confirmed by GC-MS. The oil seed presented 75% and 25% of unsaturated and saturated fatty acids, respectively. Linoleic acid (C18:1n-6, cis) was the major fatty acid (ranging from 145 to 270 mg.g-1dry mass), followed by oleic acid (31 e 83 mg.g-1d.m) and palmitic acid (21 to 47 mg.g-1d.m). Isomers of tocopherols (?, ?, ? e ?-tocopherol) were detected and quantified, where ? and ?-tocopherols were present in higher amount (27 and 25 mg.kg-1d.m., respectively). Sensory analysis for the difference from the control test showed that the concentrations 1.15 and 2% of the added extract have altered the appearance attributes, aroma and taste of the nectar, however, this change was also related to the origin of the fruits. On the other hand, the acceptance test showed high variability in scores according to the assessors profile and a trend in reducing the nectar acceptance when increasing the seed extract concentration Advisors/Committee Members: UNIVERSIDADE ESTADUAL DE CAMPINAS (CRUESP), Godoy, Helena Teixeira, 1957- (advisor), Universidade Estadual de Campinas. Faculdade de Engenharia de Alimentos (institution), Programa de Pós-Graduação em Ciência de Alimentos (nameofprogram), Schroder, Claudia Hoffmann Kowalski (committee member), Ballus, Cristiano Augusto (committee member), Rodrigues, Daniele (committee member), Prado, Marcelo Alexandre (committee member).

Subjects/Keywords: Liofilização; Hemólise; Compostos fenólicos; Tocoferois; Ácidos graxos; Lyophilization; Hemolysis; Phenolics compounds; Tocopherols; Fatty acids

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Souza, Danilo Santos, 1. (2015). Caracterização e avaliação da capacidade antioxidante da polpa liofilizada enriquecida com extrato aquoso da semente de tamarindo (Tamarindus indica): Characterization and evaluation of the antioxidant capacity of freeze-dried pulp enriched with aqueous extract of tamarind (Tamarindus indica) seed. (Thesis). Universidade Estadual de Campinas. Retrieved from http://repositorio.unicamp.br/jspui/handle/REPOSIP/254306

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Souza, Danilo Santos, 1985. “Caracterização e avaliação da capacidade antioxidante da polpa liofilizada enriquecida com extrato aquoso da semente de tamarindo (Tamarindus indica): Characterization and evaluation of the antioxidant capacity of freeze-dried pulp enriched with aqueous extract of tamarind (Tamarindus indica) seed.” 2015. Thesis, Universidade Estadual de Campinas. Accessed January 15, 2021. http://repositorio.unicamp.br/jspui/handle/REPOSIP/254306.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Souza, Danilo Santos, 1985. “Caracterização e avaliação da capacidade antioxidante da polpa liofilizada enriquecida com extrato aquoso da semente de tamarindo (Tamarindus indica): Characterization and evaluation of the antioxidant capacity of freeze-dried pulp enriched with aqueous extract of tamarind (Tamarindus indica) seed.” 2015. Web. 15 Jan 2021.

Vancouver:

Souza, Danilo Santos 1. Caracterização e avaliação da capacidade antioxidante da polpa liofilizada enriquecida com extrato aquoso da semente de tamarindo (Tamarindus indica): Characterization and evaluation of the antioxidant capacity of freeze-dried pulp enriched with aqueous extract of tamarind (Tamarindus indica) seed. [Internet] [Thesis]. Universidade Estadual de Campinas; 2015. [cited 2021 Jan 15]. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/254306.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Souza, Danilo Santos 1. Caracterização e avaliação da capacidade antioxidante da polpa liofilizada enriquecida com extrato aquoso da semente de tamarindo (Tamarindus indica): Characterization and evaluation of the antioxidant capacity of freeze-dried pulp enriched with aqueous extract of tamarind (Tamarindus indica) seed. [Thesis]. Universidade Estadual de Campinas; 2015. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/254306

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universidade Estadual de Campinas

28. Tonassé, Wouitchékpo Vincent, 1988-. Marcadores de hemólise intravascular, de inflamação e de hipercoagulabilidade em pacientes com anemia falciforme com e sem uso de hidroxiuréia : Intravascular hemolysis, inflammation and hypercoagulability markers in sickle cell anemia patients with and without hydroxyurea therapy: Intravascular hemolysis, inflammation and hypercoagulability markers in sickle cell anemia patients with and without hydroxyurea therapy.

Degree: 2018, Universidade Estadual de Campinas

URL: http://repositorio.unicamp.br/jspui/handle/REPOSIP/334861

► Abstract: Plasma hemoglobin (pHb) released from intravascular hemolysis (IH) and its heme component have been found to trigger specific pathophysiologies as abnormal endothelial activation, vasooclusion,… (more)

▼ Abstract: Plasma hemoglobin (pHb) released from intravascular hemolysis (IH) and its heme component have been found to trigger specific pathophysiologies as abnormal endothelial activation, vasooclusion, inflammation and clinical manifestations, such as thrombosis, stroke, and renal impairment in patients with Sickle cell anemia (SCA). However, the role of IH in the pathophysiology of SCA is not fully understood. In the present study, we evaluated the relation between IH markers [LDH, pHb, Haptoglobin (Hp) and Hemopexin (Hpx)], inflammation markers [C-reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor ? (TNF?), and soluble Vascular Cell Adhesion Molecule 1 (sVCAM-1)] and hypercoagulability markers [D-dimer, fibrinogen, and antigen von Willebrand Factor (vWF: Ag)] in 60 adult patients with SCA divided into two groups: 32 patients who had never been treated with hydroxyurea (HbSS) and 28 patients on hydroxyurea therapy (HbSS-HU), all in steady state, and 32 adult HbAA healthy controls who were Biomedical science students, African descendants, from Pernambuco, northeastern region of Brazil. The levels of Hp, Hpx, pHb, IL-6, TNF?, and sVCAM-1, were measured by ELISA, while CRP and LDH concentrations were measured by immunonephelometric and enzymatic colorimetric tests, respectively. Fibrinogen levels were accessed by turbidimetric and chronometric methods while D-dimer and vWF:Ag levels were measured by immunoturbidimetric assay. In this study, Hp levels have been found in this order HbSSHbAA, PsVCAM=0.012, PIL-6<0.0001, PCRP<0.0001) than in controls. Concerning hypercoagulability markers, D-dimer levels were found in the following order (HbSS>HbSS-HU>HbAA, P<0.0001), while fibrinogen levels were lower in HbSS than controls (HbSS < HbAA, P<0.001). Moreover, vWF:Ag levels were significantly higher in patients than controls (patients>HbAA, P<0.0001). Regarding associations between IH and inflammation markers, in the HbSS cohort, serum Hp levels were strongly negatively correlated with sVCAM levels (r = -0.743, P<0,0001), and Hpx levels were negatively correlated with TNF-?, (r = -0.527, P=0.011). Whereas in HbSS-HU group, Hpx levels were also negatively correlated with sVCAM levels (r = -0.481, P=0.010). With respect to associations of IH markers with hypercoagulability markers, In HbSS cohort, it has been found a negative correlation between: LDH and fibrinogen levels (r = -0.356, P=0.049); pHb and fibrinogen levels (r = -0.380, P=0.035). Whereas, Hpx levels were positively correlated with fibrinogen levels (r = 0.395, P=0.034) and platelets count (r = 0.483, P=0.008). On the other hand, in HbSS-HU cohort, Hpx levels were negatively correlated with vWF:Ag levels (r = -0.442, P=0.021). Overall, Hp and Hpx were significantly associated with vascular inflammation in SCA. In addition, IH markers were associated with more activation of coagulation and fibrinogen consumption in SCA hydroxyurea-naïve patients. On the other hand, hydroxyurea is associated with a reduction in the IH rate and reduction of… Advisors/Committee Members: UNIVERSIDADE ESTADUAL DE CAMPINAS (CRUESP), Santos, Magnun Nueldo Nunes dos, 1984- (advisor), Sonati, Maria de Fátima, 1958- (coadvisor), Universidade Estadual de Campinas. Faculdade de Ciências Médicas (institution), Programa de Pós-Graduação em Ciências Médicas (nameofprogram), Bertuzzo, Carmen Sílvia (committee member), Lanaro, Carolina (committee member), Gonçalves, Marilda de Souza (committee member), Figueiredo, Maria Stella (committee member).

Subjects/Keywords: Anemia falciforme; Hemólise; Inflamação; Trombofilia; Hidroxiureia; Sickle cell anemia; Hemolysis; Inflammation; Hypercoagulability; Hydroxyurea

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Tonassé, Wouitchékpo Vincent, 1. (2018). Marcadores de hemólise intravascular, de inflamação e de hipercoagulabilidade em pacientes com anemia falciforme com e sem uso de hidroxiuréia : Intravascular hemolysis, inflammation and hypercoagulability markers in sickle cell anemia patients with and without hydroxyurea therapy: Intravascular hemolysis, inflammation and hypercoagulability markers in sickle cell anemia patients with and without hydroxyurea therapy. (Thesis). Universidade Estadual de Campinas. Retrieved from http://repositorio.unicamp.br/jspui/handle/REPOSIP/334861

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Tonassé, Wouitchékpo Vincent, 1988-. “Marcadores de hemólise intravascular, de inflamação e de hipercoagulabilidade em pacientes com anemia falciforme com e sem uso de hidroxiuréia : Intravascular hemolysis, inflammation and hypercoagulability markers in sickle cell anemia patients with and without hydroxyurea therapy: Intravascular hemolysis, inflammation and hypercoagulability markers in sickle cell anemia patients with and without hydroxyurea therapy.” 2018. Thesis, Universidade Estadual de Campinas. Accessed January 15, 2021. http://repositorio.unicamp.br/jspui/handle/REPOSIP/334861.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Tonassé, Wouitchékpo Vincent, 1988-. “Marcadores de hemólise intravascular, de inflamação e de hipercoagulabilidade em pacientes com anemia falciforme com e sem uso de hidroxiuréia : Intravascular hemolysis, inflammation and hypercoagulability markers in sickle cell anemia patients with and without hydroxyurea therapy: Intravascular hemolysis, inflammation and hypercoagulability markers in sickle cell anemia patients with and without hydroxyurea therapy.” 2018. Web. 15 Jan 2021.

Vancouver:

Tonassé, Wouitchékpo Vincent 1. Marcadores de hemólise intravascular, de inflamação e de hipercoagulabilidade em pacientes com anemia falciforme com e sem uso de hidroxiuréia : Intravascular hemolysis, inflammation and hypercoagulability markers in sickle cell anemia patients with and without hydroxyurea therapy: Intravascular hemolysis, inflammation and hypercoagulability markers in sickle cell anemia patients with and without hydroxyurea therapy. [Internet] [Thesis]. Universidade Estadual de Campinas; 2018. [cited 2021 Jan 15]. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/334861.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Tonassé, Wouitchékpo Vincent 1. Marcadores de hemólise intravascular, de inflamação e de hipercoagulabilidade em pacientes com anemia falciforme com e sem uso de hidroxiuréia : Intravascular hemolysis, inflammation and hypercoagulability markers in sickle cell anemia patients with and without hydroxyurea therapy: Intravascular hemolysis, inflammation and hypercoagulability markers in sickle cell anemia patients with and without hydroxyurea therapy. [Thesis]. Universidade Estadual de Campinas; 2018. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/334861

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universidade Federal de Viçosa

29. Lukiya Silva Campos Favarato. Continuous infusion anesthesia using etomidate and etomidate associated with remifentanil in cats premedicated with acepromazine.

Degree: 2009, Universidade Federal de Viçosa

URL: http://www.tede.ufv.br/tedesimplificado/tde_busca/arquivo.php?codArquivo=2524

► The imidazole derivative etomidate is classified as a non-barbituric general anesthetic with hypnotic action for intravenous usage. Remifentanil is a selective μ- receptor agonist opioid… (more)

▼ The imidazole derivative etomidate is classified as a non-barbituric general anesthetic with hypnotic action for intravenous usage. Remifentanil is a selective μ- receptor agonist opioid of ultra-short action and high analgesic potency with an unique pharmacokinetic due to a lateral metil-ester branch that allows a fast metabolism by non-specific esterases (carboxylesterases) present in blood and tissues. Twenty female mongrel cats were used, all healthy, with a mean weight of 3.50.49 kg, admitted for an elective overiohysterectomy. Pre-anesthetic medication was made with acepromazine, 0.1mg.Kg-1 intravenously, and etomidate was used for anesthetic induction, also intravenously, on a dose of 3 mg.kg-1. Continuous act, animals were randomly divided in 2 groups of 10 animals each, maintaining anesthesia for 45 minutes using the protocols: for group 1 (IE), continuous infusion of etomidate at a rate of 0.4 mg.kg- 1.min-1; for group 2 (IER), continuous infusion of etomidate and remifentanil at rates of 0.3 mg.kg-1.min-1 and 0.4 μg.kg-1.min-1, respectively. The following parameters where analyzed: heart rate; oxyhemoglobin saturation; systolic arterial pressure; respiratory rate; body temperature; arterial blood gas; sodium, potassium, ionized calcium, chloride and glucose dosages; autonomic responses to nociceptive stimulus; electrocardiogram; palpebral, corneal, laryngeal and tracheal reflexes; time needed for recovery from the anesthesia; adverse effects record; final solution osmolarity; total number of erythrocytes; hematocrit; hemoglobin measure; total, direct and indirect bilirrubin; plasma free hemoglobin; haptoglobin and; erythrocyte fragility. Scheduled times for measurements were T0 (before), before pre-anesthetic administration (MPA); T1 (MPA), 20 minutes after MPA; T2 (5 min), 5 minutes after anesthetic induction and orotracheal intubation; T3 (15 min), T4 (30min), T5 (45min) and T6 (3h 45min) at 15, 30, 45 and 3 hours and 45 minutes after T2, respectively. Continuous infusion of etomidate and its association with remifentanil in cats promoted heart rate and blood pressure stability, hypoventilation and respiratory acidosis. Etomidate in continuous infusion could not suppress autonomic responses to nociceptive stimulus and so, inadequate for surgery procedures. Etomidate associated to remifentanil efficiently controlled autonomic responses to nociceptive stimulus before and after surgery. Both the infusions tested promoted transitory hyperglycemia during anesthesia and after it. Etomidate associated or not with remifentanil by continuous infusion promoted a longer recovery with intense side effects such as myoclonus and emesis. Etomidate and etomidate associated with remifentanil infusions, associated with acepromazine promoted important decrease in erythrocytes number, hematocrit and hemoglobin. Both the infusions tested promoted increases in free hemoglobin and bilirrubin and decrease of haptaglobin as a result of intravascular hemolysis. Etomidate alone and its association with remifentanil in… Advisors/Committee Members: Luiz Gonzaga Pompermayer, José Dantas Ribeiro Filho, Ricardo Junqueira Del Carlo, Aloísio da Silva Pinto, Humberto Pereira Oliveira, Fernanda Antunes.

Subjects/Keywords: Infusão contínua; Etomidato; Hemólise; Rumifentanil; ANESTESIOLOGIA ANIMAL; Continuous infusion; Etomidate; Hemolysis; Remifentanil

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Favarato, L. S. C. (2009). Continuous infusion anesthesia using etomidate and etomidate associated with remifentanil in cats premedicated with acepromazine. (Thesis). Universidade Federal de Viçosa. Retrieved from http://www.tede.ufv.br/tedesimplificado/tde_busca/arquivo.php?codArquivo=2524

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Favarato, Lukiya Silva Campos. “Continuous infusion anesthesia using etomidate and etomidate associated with remifentanil in cats premedicated with acepromazine.” 2009. Thesis, Universidade Federal de Viçosa. Accessed January 15, 2021. http://www.tede.ufv.br/tedesimplificado/tde_busca/arquivo.php?codArquivo=2524.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Favarato, Lukiya Silva Campos. “Continuous infusion anesthesia using etomidate and etomidate associated with remifentanil in cats premedicated with acepromazine.” 2009. Web. 15 Jan 2021.

Vancouver:

Favarato LSC. Continuous infusion anesthesia using etomidate and etomidate associated with remifentanil in cats premedicated with acepromazine. [Internet] [Thesis]. Universidade Federal de Viçosa; 2009. [cited 2021 Jan 15]. Available from: http://www.tede.ufv.br/tedesimplificado/tde_busca/arquivo.php?codArquivo=2524.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Favarato LSC. Continuous infusion anesthesia using etomidate and etomidate associated with remifentanil in cats premedicated with acepromazine. [Thesis]. Universidade Federal de Viçosa; 2009. Available from: http://www.tede.ufv.br/tedesimplificado/tde_busca/arquivo.php?codArquivo=2524

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universidade Estadual de Campinas

30. Jacqueline Darc da Silva Thome. Citotoxinas e hemolisinas produzidas por Campylobacter jejuni isolados de diferentes origens.

Degree: Instituto de Biologia, 2006, Universidade Estadual de Campinas

URL: http://libdigi.unicamp.br/document/?code=vtls000383382

►

Membros termofílicos do gênero Campylobacter são reconhecidos como importantes enteropatógenos para o homem e também para outros animais. A grande diversidade ecológica deste microrganismo, encontrado… (more)

▼

Membros termofílicos do gênero Campylobacter são reconhecidos como importantes enteropatógenos para o homem e também para outros animais. A grande diversidade ecológica deste microrganismo, encontrado em diferentes habitat tais como: águas, animais e alimentos, indica que estudos sobre os diversos fatores de virulência poderiam contemplar este diferenciado nicho ecológico. Neste trabalho, pretendeu-se detectar fenotípica a freqüência de quatro tipos de citotoxinas já descritas em C. jejuni: a toxina cito letal distensora (CDT); a citotoxina de 70k-Da, a citotoxina ativa somente em células Vero e a toxina cito1etal de arredondamento (CLTR) em 80 amostras de C. jejuni isoladas de diferentes origens. Realizou-se também a detecção da toxina CDT pela técnica da PCR e ainda a detecção da atividade hemolítica em todas as amostras. Das 80 amostras estudadas, 57 foram positivas para CDT (71,25%), sendo 15 amostras positivas (18,75%) detectadas de fígado de frango, três (3,75%) de águas residuais, 19 (23,75%) de origem animal e 20 (25%) de origem humana. O percentua1 de positividade para toxinas CLRT (20%) representada por um número de 16 amostras, foi de duas amostras de origem alimentar (2,5%), 11 de origem animal (13,75%) e três de origem humana (3,75%) dentro do percentual total das amostras analisadas. Para a citotoxina de 70k-Da, de um total de 7 amostras positivas (8,75%), o percentua1 de positividade foi de duas amostras de origem animal (2,5%) e cinco amostras de origem animal (6,25%). Nenhuma amostra foi positiva para a citotoxina ativa somente em células Vero. Na análise da expressão de hemo1isina obtivemos; três amostras positivas (3,75%) em hemácias de cavalo, uma amostra positiva (1,25%) em hemácias de carneiro, 22 (27,5%) em hemácias de boi, 27 (33,75%) em hemácias de cobaia e 16 (20%) em hemácias de galinha, no total das 80 amostras em estudo, sem correlação com a respectiva origem de isolamento. Os agentes que1antes de ferro (EDDA) e os íons bivalentes (EDT A, cálcio, magnésio e ferro) utilizados no meio de cultivo aumentaram a expressão da hemo1isina quando testadas nas hemácias de carneiro e cavalo. O aumento foi de 25%, 21,25%, 7,5%,8,75% e 15% em hemácias de carneiro acrescida das soluções CaC}z, MgC}z, FeCh, EDTA e EDDA, respectivamente, e de 12,5%, 6,25%, 0%, 6,25% e 12,5%, para as amostras testadas com hemácias de cavalo. Quanto a análise da presença do gene cdtB, o percentual de positividade encontrado, foi de 100%,92%,87% e 85% nas amostragens ambiental, humana, animal e alimentar, respectivamente. Finalizando, este trabalho vem colaborar com a demanda de mais estudos sobre a campilobacteriose no Brasil, uma vez que a pesquisa de fatores de virulência e dados epidemio1ógicos sobre este patógeno são ainda escassos em nosso país

Thermophilic members of genus Campylobacter are recognized as important enteric pathogens for man and animaIs. The great ecological diversity of this microorganism, found in several habitat, such as waters, animaIs and foods, indicates that studies of many virulence factors…

Advisors/Committee Members: Tomomasa Yano, Ana Luzia Lauria Filgueiras, Maria Silvia Viccari Gatti.

Subjects/Keywords: Cytotoxins; Campylobacter jejuni; Hemolise e hemolisinas; Virulence factors; Fatores de virulencia; Citotoxinas; Hemolysis and hemolysins

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Thome, J. D. d. S. (2006). Citotoxinas e hemolisinas produzidas por Campylobacter jejuni isolados de diferentes origens. (Thesis). Universidade Estadual de Campinas. Retrieved from http://libdigi.unicamp.br/document/?code=vtls000383382

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Thome, Jacqueline Darc da Silva. “Citotoxinas e hemolisinas produzidas por Campylobacter jejuni isolados de diferentes origens.” 2006. Thesis, Universidade Estadual de Campinas. Accessed January 15, 2021. http://libdigi.unicamp.br/document/?code=vtls000383382.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Thome, Jacqueline Darc da Silva. “Citotoxinas e hemolisinas produzidas por Campylobacter jejuni isolados de diferentes origens.” 2006. Web. 15 Jan 2021.

Vancouver:

Thome JDdS. Citotoxinas e hemolisinas produzidas por Campylobacter jejuni isolados de diferentes origens. [Internet] [Thesis]. Universidade Estadual de Campinas; 2006. [cited 2021 Jan 15]. Available from: http://libdigi.unicamp.br/document/?code=vtls000383382.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Thome JDdS. Citotoxinas e hemolisinas produzidas por Campylobacter jejuni isolados de diferentes origens. [Thesis]. Universidade Estadual de Campinas; 2006. Available from: http://libdigi.unicamp.br/document/?code=vtls000383382

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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Open Access Theses and Dissertations