subject:(Hemodynamics)

University of Illinois – Urbana-Champaign

1. Kistler, Brandon. Acute effects of intradialytic nutrition supplementation on hemodynamics, treatment efficiency, and gastrointestinal symptoms in maintenance hemodialysis patients.

Degree: PhD, Kinesiology, 2015, University of Illinois – Urbana-Champaign

URL: http://hdl.handle.net/2142/89194

► Poor nutritional status is common and among the strongest predictors of mortality in patients undergoing maintenance hemodialysis (HD) treatment. Reduced dietary intake, especially on days… (more)

▼ Poor nutritional status is common and among the strongest predictors of mortality in patients undergoing maintenance hemodialysis (HD) treatment. Reduced dietary intake, especially on days in which patients undergo treatment, is one factor that contributes to this poor nutritional status. Providing nutritional supplements or allowing patients to eat during HD treatment can help restore dietary intake, improve nutritional status, and significantly reduce mortality in malnourished patients. However, in the United States this practice is frequently restricted due to concerns about patient safety. To better understand practice patterns related to eating during HD treatment we conducted an international survey. We received 73 responses representing clinics in six continents. Among this cohort, 61 of 73 clinicians (85%) were at clinics that allowed patients to eat during treatment and 53 (73%) were at clinics that provided food during treatment. Interestingly, none of the nine clinics from North America provided food during treatment. In the second part of this survey, we asked the 61 clinicians who were at clinics which allowed patients to eat during treatment about their experience with the six most-cited reasons to restrict eating during treatment using a four point scale. Clinicians responded that they observed choking (98%), reduced Kt/V (98%), infection control issues (96%), spills or pests (83%), gastrointestinal issues (71%), and hypotension (62%) either “rarely” or “never.” The results of our survey suggested that gastrointestinal (GI) issues were amongst the conditions most frequently attributed to eating during HD treatment. However, there have been no studies directly examining the effects of providing nutrition on these symptoms. One reason for this lack of data may have been the absence of a validated tool to measure GI symptoms. Therefore, we developed and validated a questionnaire to measure GI symptoms associated with a single HD treatment. Following a brief face validation with renal dietitians, we recruited 50 maintenance HD patients and administered our survey following a mid-week HD treatment. During the same treatment we measured dietary intake by diet recall. Three weeks later we repeated this process. In general, we found good agreement between items in each domain and repeatability among individual domains. Prevalence of GI symptoms during treatment (77.1%) was much higher than previously reported and associated with the intake of fat (r=.318, p = 0.027) and fiber (.386, p = 0.007) during treatment. At the same time as our validation study, we also sought to determine the effect that liquid supplements had on the symptoms commonly associated with eating during treatment. We used a within-subjects design (n=8) to compare standard HD treatment (HD) to a standard HD treatment in which patients ingested 30 grams of whey protein starting 30 minutes into their treatment (HD + Protein). We found no interaction between groups in any hemodynamic variable (p>0.05). However, there was a main-effect of… Advisors/Committee Members: Wilund, Kenneth (advisor), Wilund, Kenneth (Committee Chair), De Lisio, Mike (committee member), Chapman-Novakofski, Karen (committee member), Heffernan, Kevin (committee member), Ikizler, Alp (committee member).

Subjects/Keywords: Hemodynamics; Intradialytic Nutrition

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APA (6^th Edition):

Kistler, B. (2015). Acute effects of intradialytic nutrition supplementation on hemodynamics, treatment efficiency, and gastrointestinal symptoms in maintenance hemodialysis patients. (Doctoral Dissertation). University of Illinois – Urbana-Champaign. Retrieved from http://hdl.handle.net/2142/89194

Chicago Manual of Style (16^th Edition):

Kistler, Brandon. “Acute effects of intradialytic nutrition supplementation on hemodynamics, treatment efficiency, and gastrointestinal symptoms in maintenance hemodialysis patients.” 2015. Doctoral Dissertation, University of Illinois – Urbana-Champaign. Accessed July 24, 2019. http://hdl.handle.net/2142/89194.

MLA Handbook (7^th Edition):

Kistler, Brandon. “Acute effects of intradialytic nutrition supplementation on hemodynamics, treatment efficiency, and gastrointestinal symptoms in maintenance hemodialysis patients.” 2015. Web. 24 Jul 2019.

Vancouver:

Kistler B. Acute effects of intradialytic nutrition supplementation on hemodynamics, treatment efficiency, and gastrointestinal symptoms in maintenance hemodialysis patients. [Internet] [Doctoral dissertation]. University of Illinois – Urbana-Champaign; 2015. [cited 2019 Jul 24]. Available from: http://hdl.handle.net/2142/89194.

Council of Science Editors:

Kistler B. Acute effects of intradialytic nutrition supplementation on hemodynamics, treatment efficiency, and gastrointestinal symptoms in maintenance hemodialysis patients. [Doctoral Dissertation]. University of Illinois – Urbana-Champaign; 2015. Available from: http://hdl.handle.net/2142/89194

University of Utah

2. Doig, Alexa K. Graphical cardiovascular display for hemodynamic monitoring;.

Degree: PhD, Nursing;, 2006, University of Utah

URL: http://content.lib.utah.edu/cdm/singleitem/collection/etd1/id/573/rec/595

► During emergent situations critical care nurses must recognize changes in the patient's condition, rapidly select relevant hemodynamic variables, then interpret the data in order to… (more)

▼ During emergent situations critical care nurses must recognize changes in the patient's condition, rapidly select relevant hemodynamic variables, then interpret the data in order to intervene appropriately. Studies in anesthesia have shown that graphical monitoring displays have the potential to improve detection and management of adverse physiological events. Despite the fact that nurses are the primary users of patient monitoring technologies, the application of graphical displays has not been well explored within the domain of nursing practice. The first aim of this research was to describe the cognitive aspects of the hemodynamic monitoring task of critical care nurses. The data, collected during interviews with 13 nurses, supported the use of graphical displays in hemodynamic monitoring and the findings were used as the basis for a series of preliminary display design strategy recommendations. The second aim was to compare the performance of critical care nurses using a new integrated graphical cardiovascular display versus a traditional numerical-waveform display to interpret hemodynamic data using a computerized, scenario-based test (n = 15/group). Although use of the graphical display did not improve accuracy of data interpretation, it did not significantly reduce it, despite limited training on the new graphical display technology. Response times among the two display conditions were equivalent. On subjective measures, the graphical display was favorably rated in terms of acceptance and usability. Interviews conducted following the display testing sessions found that nurses using the graphical display used fewer variables in their assessment, as well as more conceptual but less precise language during the interview. Nurses who used imprecise language scored lower on the scenario-based test, regardless of display type. The most common sources of error among nurses in both display conditions were inattention to key variables, misinterpretation of variables, and being misled by the patient's history. Graphical displays for hemodynamic monitoring may be able to enhance nursing practice with relevant, cue-based design development and additional training prior to testing. Advancing the design of monitoring displays for use by critical care nurses also requires further study of the cognitive tasks involved in patient monitoring and the sources of error during data interpretation.

Subjects/Keywords: Nursing; Hemodynamics

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APA (6^th Edition):

Doig, A. K. (2006). Graphical cardiovascular display for hemodynamic monitoring;. (Doctoral Dissertation). University of Utah. Retrieved from http://content.lib.utah.edu/cdm/singleitem/collection/etd1/id/573/rec/595

Chicago Manual of Style (16^th Edition):

Doig, Alexa K. “Graphical cardiovascular display for hemodynamic monitoring;.” 2006. Doctoral Dissertation, University of Utah. Accessed July 24, 2019. http://content.lib.utah.edu/cdm/singleitem/collection/etd1/id/573/rec/595.

MLA Handbook (7^th Edition):

Doig, Alexa K. “Graphical cardiovascular display for hemodynamic monitoring;.” 2006. Web. 24 Jul 2019.

Vancouver:

Doig AK. Graphical cardiovascular display for hemodynamic monitoring;. [Internet] [Doctoral dissertation]. University of Utah; 2006. [cited 2019 Jul 24]. Available from: http://content.lib.utah.edu/cdm/singleitem/collection/etd1/id/573/rec/595.

Council of Science Editors:

Doig AK. Graphical cardiovascular display for hemodynamic monitoring;. [Doctoral Dissertation]. University of Utah; 2006. Available from: http://content.lib.utah.edu/cdm/singleitem/collection/etd1/id/573/rec/595

Cornell University

3. Lindsey, Stephanie. Hemodynamic Regulation Of Cardiac Outflow Morphogenesis .

Degree: 2016, Cornell University

URL: http://hdl.handle.net/1813/43703

► Throughout development, blood flow guides cardiac morphogenesis, sculpting tissue by promoting growth in response to increased mechanical demands. Alterations in flow patterns during critical stages… (more)

▼ Throughout development, blood flow guides cardiac morphogenesis, sculpting tissue by promoting growth in response to increased mechanical demands. Alterations in flow patterns during critical stages of development may therefore lead to adverse tissue remodeling and subsequent functional cardiac defects. Distinguishing the specific effects due to hemodynamics and genetic mutations is a current challenge, as the role of hemodynamics in outflow tract and pharyngeal arch artery morphogenesis is poorly understood. There exists a need for more clinically relevant animal models that allow for the study of disease pathogenesis both structurally and molecularly. My work begins to delineate the effects of structural changes resulting from abnormal hemodynamic patterning and elucidate their effects in the creation of congenital heart defects through a combination of experimental interventions and computational modeling. Two- photon microscopy guided femtosecond laser pulses were used to nucleate and control the growth of cavitation bubbles within developing outflow vessels without disturbing surrounding tissues. These cavitation bubbles temporarily occluded the vessel, while a more stable occlusion while a more stable occlusion was formed by ablating the circulating thrombocytes that accumulated behind the bubble. Using this approach, I examined the effects of PAA vessel occlusions on embryonic viability, hemodynamic rearrangement, and downstream outflow tract morphogenesis (Chapter 3). A zero-dimensional (0D) electric analog model that allows for global tuning of the embryo's vasculature relative to the arches was developed (Chapter 4). A 3D-0D model was used to characterize natural variation in day3, day4, and day 5 arch artery pressure, flow, and shape changes. These 0D bounds served as a basis for prediction of flow distribution to the cranial and caudal outlets when switching between normal and aberrant flow (Chapter 5). Results revealed distinct morphology dynamics for day3, day4, and day 5 geometries, as well as natural shifts in arch artery dominance at different stages and across individual days. Immediate remodeling of the arch artery vasculature took place following day 3 experimental occlusions. In some embryos, that remodeling worked to lessen the severity of increased pressure magnitude in the cranial part of the aortic sac. My findings contribute a more detailed picture of arch artery growth and adaptation across a critical window of development. Advisors/Committee Members: Noden,Drew Morrison (committeeMember), Schaffer,Chris (committeeMember), Vignon-Clementel,Irene (committeeMember).

Subjects/Keywords: hemodynamics; cardiogenesis; mathematical modeling

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APA (6^th Edition):

Lindsey, S. (2016). Hemodynamic Regulation Of Cardiac Outflow Morphogenesis . (Thesis). Cornell University. Retrieved from http://hdl.handle.net/1813/43703

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Lindsey, Stephanie. “Hemodynamic Regulation Of Cardiac Outflow Morphogenesis .” 2016. Thesis, Cornell University. Accessed July 24, 2019. http://hdl.handle.net/1813/43703.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Lindsey, Stephanie. “Hemodynamic Regulation Of Cardiac Outflow Morphogenesis .” 2016. Web. 24 Jul 2019.

Vancouver:

Lindsey S. Hemodynamic Regulation Of Cardiac Outflow Morphogenesis . [Internet] [Thesis]. Cornell University; 2016. [cited 2019 Jul 24]. Available from: http://hdl.handle.net/1813/43703.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Lindsey S. Hemodynamic Regulation Of Cardiac Outflow Morphogenesis . [Thesis]. Cornell University; 2016. Available from: http://hdl.handle.net/1813/43703

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Texas A&M University

4. Nguyen, Phuc Hoang. Integrating Biomechanics, Hemodynamics, and Vascular Adaptation to Relate Mechanisms of Vascular Adaptation to Arterial Pulsatile Pressure in Health and Disease.

Degree: 2014, Texas A&M University

URL: http://hdl.handle.net/1969.1/153567

► The inherent complexity of the mammalian systemic arterial system has presented numerous challenges to relating basic vascular biology to clinically-relevant derangements of blood pressures and… (more)

▼ The inherent complexity of the mammalian systemic arterial system has presented numerous challenges to relating basic vascular biology to clinically-relevant derangements of blood pressures and flows. The field of biomechanics has identified how local changes in pulsatile blood pressures and flows lead to changes in local endothelial shear stress and circumferential wall stress. The field of mechanobiology has identified how local changes in wall circumferential stress and endothelial shear stress lead to changes in arterial radii, wall thicknesses and stiffnesses. The field of pulsatile hemodynamics has identified how changes in local radii, wall thicknesses and stiffnesses lead to changes in the complex distributions of pressures and flows throughout an arterial network. These three fields have primarily been studied in isolation, and yet the properties of a single vessel emerge from the interaction of these three processes. The effect of adaptation of one artery on hemodynamics, stress, and structure of all other vessels in the network makes the arterial system a complex adaptive system that is difficult to study experimentally. This dissertation addresses this unmet need by integrating hemodynamics, vessel mechanics, and vascular adaptation by developing a novel framework with mathematical models at different scales. Allowing arteries simultaneously to adapt to mechanical stresses in a computational model of the human systemic arterial system, the present work illustrated that simple arterial adaptation to wall circumferential and endothelial shear stresses are sufficient to explain nine salient features of the cardiovascular system when traversing away from the aortic root towards the peripheral arteries: decrease in lumen radii, wall thicknesses, vessel compliances, shear stresses, wall stresses and pulsatile flows, and increase in wall stiffnesses, pulse wave velocities, and pulsatile pressures. In addition, it revealed that pulse pressure homeostasis emerges to mechanical perturbations such as reduced ejection fraction, increased peripheral resistance and aortic coarctation. Finally, it illustrated how changes in sensitivity of arterial adaptation to pulsatile wall stress can lead to manifestations of disease states such as increased pulse wave velocity and isolated systolic hypertension. The governing principles leading to the emergence of complex, adaptive behavior in the systemic arterial system have thus been identified. Advisors/Committee Members: Quick, Christopher M. (advisor), Stewart, Randolph H. (committee member), Criscione, John C. (committee member), Dongaonkar, Ranjeet M. (committee member).

Subjects/Keywords: hemodynamics; vascular adaptation; biomechanics

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APA (6^th Edition):

Nguyen, P. H. (2014). Integrating Biomechanics, Hemodynamics, and Vascular Adaptation to Relate Mechanisms of Vascular Adaptation to Arterial Pulsatile Pressure in Health and Disease. (Thesis). Texas A&M University. Retrieved from http://hdl.handle.net/1969.1/153567

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Nguyen, Phuc Hoang. “Integrating Biomechanics, Hemodynamics, and Vascular Adaptation to Relate Mechanisms of Vascular Adaptation to Arterial Pulsatile Pressure in Health and Disease.” 2014. Thesis, Texas A&M University. Accessed July 24, 2019. http://hdl.handle.net/1969.1/153567.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Nguyen, Phuc Hoang. “Integrating Biomechanics, Hemodynamics, and Vascular Adaptation to Relate Mechanisms of Vascular Adaptation to Arterial Pulsatile Pressure in Health and Disease.” 2014. Web. 24 Jul 2019.

Vancouver:

Nguyen PH. Integrating Biomechanics, Hemodynamics, and Vascular Adaptation to Relate Mechanisms of Vascular Adaptation to Arterial Pulsatile Pressure in Health and Disease. [Internet] [Thesis]. Texas A&M University; 2014. [cited 2019 Jul 24]. Available from: http://hdl.handle.net/1969.1/153567.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Nguyen PH. Integrating Biomechanics, Hemodynamics, and Vascular Adaptation to Relate Mechanisms of Vascular Adaptation to Arterial Pulsatile Pressure in Health and Disease. [Thesis]. Texas A&M University; 2014. Available from: http://hdl.handle.net/1969.1/153567

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Canterbury

5. Alzaidi, Samara Samir. Computational Models of Cerebral Hemodynamics.

Degree: Mechanical Engineering, 2009, University of Canterbury

URL: http://hdl.handle.net/10092/3159

► The cerebral tissue requires a constant supply of oxygen and nutrients. This is maintained through delivering a constant supply of blood. The delivery of sufficient… (more)

▼ The cerebral tissue requires a constant supply of oxygen and nutrients. This is maintained through delivering a constant supply of blood. The delivery of sufficient blood is preserved by the cerebral vasculature and its autoregulatory function. The cerebral vasculature is composed of the Circle of Willis (CoW), a ring-like anastomoses of arteries at the base of the brain, and its peripheral arteries. However, only 50% of the population have a classical complete CoW network. This implies that the route of blood flow through the cerebral vasculature is different and dependent on where the blood is needed most in the brain. Autoregulation is a mechanism held by the peripheral arteries and arterioles downstream of the CoW. It ensures the delivery of the essential amount of cerebral blood flow despite changes in the arterial perfusion pressure, through the vasoconstriction and vasodilation of the vessels. The mechanisms that control the vessels’ vasomotion could be attributed to myogenic, metabolic, neurogenic regulation or a combination of all three. However, the variations in the CoW structure, combined with different pathological conditions such as hypertension, a stenosis or an occlusion in one or more of the supplying cerebral arteries may alter, damage or abolish autoregulation, and consequently result in a stroke. Stroke is the most common cerebrovascular disease that affects millions of people in the world every year. Therefore, it is essential to understand the cerebral hemodynamics via mathematical modelling of the cerebral vasculature and its regulation mechanisms. This thesis presents the developed model of the cerebral vasculature coupled with the different forms of autoregulation mechanisms. The model was developed over multiple stages. First, a linear model of the CoW was developed, where the peripheral vessels downstream of the CoW efferent arteries are represented as lumped parameter variable resistances. The autoregulation function in the efferent arteries was modelled using a PI controller, and a metabolic model was added to the lumped peripheral variable resistances. The model was then modified so the pressure losses encountered at the CoW bifurcations, and the vessels’ tortuosity are taken into account resulting in a non-linear system. A number of cerebral autoregulation models exist in the literature, however, no model combines a fully populated arterial tree with dynamic autoregulation. The final model presented in this thesis was built by creating an asymmetric binary arterial vascular tree to replace the lumped resistance parameters for the vasculature network downstream of each of the CoW efferent arteries. The autoregulation function was introduced to the binary arterial tree by implementing the myogenic and metabolic mechanisms which are active in the small arteries and arterioles of the binary arterial tree. The myogenic and metabolic regulation mechanisms were both tested in the model. The results indicate that because of the low pressures experienced by the arterioles downstream of the…

Subjects/Keywords: Cerebral Hemodynamics; Computational Models

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APA (6^th Edition):

Alzaidi, S. S. (2009). Computational Models of Cerebral Hemodynamics. (Thesis). University of Canterbury. Retrieved from http://hdl.handle.net/10092/3159

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Alzaidi, Samara Samir. “Computational Models of Cerebral Hemodynamics.” 2009. Thesis, University of Canterbury. Accessed July 24, 2019. http://hdl.handle.net/10092/3159.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Alzaidi, Samara Samir. “Computational Models of Cerebral Hemodynamics.” 2009. Web. 24 Jul 2019.

Vancouver:

Alzaidi SS. Computational Models of Cerebral Hemodynamics. [Internet] [Thesis]. University of Canterbury; 2009. [cited 2019 Jul 24]. Available from: http://hdl.handle.net/10092/3159.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Alzaidi SS. Computational Models of Cerebral Hemodynamics. [Thesis]. University of Canterbury; 2009. Available from: http://hdl.handle.net/10092/3159

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Georgia Tech

6. Simmons, Rachel Diane. MIR-744 modulation by disturbed flow and its role in endothelial inflammation and atherosclerosis.

Degree: PhD, Biomedical Engineering (Joint GT/Emory Department), 2017, Georgia Tech

URL: http://hdl.handle.net/1853/60679

► Atherosclerosis is the leading cause of death in developed nations as it is the underlying cause of many cardiovascular diseases (CVD) such as myocardial infarction,… (more)

Subjects/Keywords: miRNAs; Hemodynamics; Atherosclerosis; Endothelial inflammation

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APA (6^th Edition):

Simmons, R. D. (2017). MIR-744 modulation by disturbed flow and its role in endothelial inflammation and atherosclerosis. (Doctoral Dissertation). Georgia Tech. Retrieved from http://hdl.handle.net/1853/60679

Chicago Manual of Style (16^th Edition):

Simmons, Rachel Diane. “MIR-744 modulation by disturbed flow and its role in endothelial inflammation and atherosclerosis.” 2017. Doctoral Dissertation, Georgia Tech. Accessed July 24, 2019. http://hdl.handle.net/1853/60679.

MLA Handbook (7^th Edition):

Simmons, Rachel Diane. “MIR-744 modulation by disturbed flow and its role in endothelial inflammation and atherosclerosis.” 2017. Web. 24 Jul 2019.

Vancouver:

Simmons RD. MIR-744 modulation by disturbed flow and its role in endothelial inflammation and atherosclerosis. [Internet] [Doctoral dissertation]. Georgia Tech; 2017. [cited 2019 Jul 24]. Available from: http://hdl.handle.net/1853/60679.

Council of Science Editors:

Simmons RD. MIR-744 modulation by disturbed flow and its role in endothelial inflammation and atherosclerosis. [Doctoral Dissertation]. Georgia Tech; 2017. Available from: http://hdl.handle.net/1853/60679

7. Moberg, Niklas. Hemodynamic Model of the Cardiovascular System during Valsalva Maneuver and Orthostatic Changes.

Degree: Radiation Physics, 2011, Umeå University

URL: http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-50044

► The goal of the Master's Thesis was to extend an existing cardiovascular model to include the mechanics of the lung, thus allowing to simulate… (more)

Subjects/Keywords: Hemodynamics; model; Valsalva; cardiovascular

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APA (6^th Edition):

Moberg, N. (2011). Hemodynamic Model of the Cardiovascular System during Valsalva Maneuver and Orthostatic Changes. (Thesis). Umeå University. Retrieved from http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-50044

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Moberg, Niklas. “Hemodynamic Model of the Cardiovascular System during Valsalva Maneuver and Orthostatic Changes.” 2011. Thesis, Umeå University. Accessed July 24, 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-50044.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Moberg, Niklas. “Hemodynamic Model of the Cardiovascular System during Valsalva Maneuver and Orthostatic Changes.” 2011. Web. 24 Jul 2019.

Vancouver:

Moberg N. Hemodynamic Model of the Cardiovascular System during Valsalva Maneuver and Orthostatic Changes. [Internet] [Thesis]. Umeå University; 2011. [cited 2019 Jul 24]. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-50044.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Moberg N. Hemodynamic Model of the Cardiovascular System during Valsalva Maneuver and Orthostatic Changes. [Thesis]. Umeå University; 2011. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-50044

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Rutgers University

8. Pitt, Ronald Andre. Arterial pressure-volume relation and augmentation index:.

Degree: MS, Biomedical Engineering, 2009, Rutgers University

URL: http://hdl.rutgers.edu/1782.2/rucore10001600001.ETD.000051064

► Hypertension is the primary precursor to all forms of heart disease which according to the CDC continues to be the leading cause of death in… (more)

Subjects/Keywords: Arteries; Blood pressure; Hemodynamics

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APA (6^th Edition):

Pitt, R. A. (2009). Arterial pressure-volume relation and augmentation index:. (Masters Thesis). Rutgers University. Retrieved from http://hdl.rutgers.edu/1782.2/rucore10001600001.ETD.000051064

Chicago Manual of Style (16^th Edition):

Pitt, Ronald Andre. “Arterial pressure-volume relation and augmentation index:.” 2009. Masters Thesis, Rutgers University. Accessed July 24, 2019. http://hdl.rutgers.edu/1782.2/rucore10001600001.ETD.000051064.

MLA Handbook (7^th Edition):

Pitt, Ronald Andre. “Arterial pressure-volume relation and augmentation index:.” 2009. Web. 24 Jul 2019.

Vancouver:

Pitt RA. Arterial pressure-volume relation and augmentation index:. [Internet] [Masters thesis]. Rutgers University; 2009. [cited 2019 Jul 24]. Available from: http://hdl.rutgers.edu/1782.2/rucore10001600001.ETD.000051064.

Council of Science Editors:

Pitt RA. Arterial pressure-volume relation and augmentation index:. [Masters Thesis]. Rutgers University; 2009. Available from: http://hdl.rutgers.edu/1782.2/rucore10001600001.ETD.000051064

University of Toronto

9. Tan, Luke. A Newborn Sex-related Response to Hyperoxia.

Degree: 2012, University of Toronto

URL: http://hdl.handle.net/1807/33867

►

Exposure to hyperoxia has been shown to have detrimental effects on newborn hemodynamics and antioxidant activities in males. These effects are unknown in the newborn… (more)

Subjects/Keywords: Hyperoxia; Hemodynamics; sex-difference; 0719

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APA (6^th Edition):

Tan, L. (2012). A Newborn Sex-related Response to Hyperoxia. (Masters Thesis). University of Toronto. Retrieved from http://hdl.handle.net/1807/33867

Chicago Manual of Style (16^th Edition):

Tan, Luke. “A Newborn Sex-related Response to Hyperoxia.” 2012. Masters Thesis, University of Toronto. Accessed July 24, 2019. http://hdl.handle.net/1807/33867.

MLA Handbook (7^th Edition):

Tan, Luke. “A Newborn Sex-related Response to Hyperoxia.” 2012. Web. 24 Jul 2019.

Vancouver:

Tan L. A Newborn Sex-related Response to Hyperoxia. [Internet] [Masters thesis]. University of Toronto; 2012. [cited 2019 Jul 24]. Available from: http://hdl.handle.net/1807/33867.

Council of Science Editors:

Tan L. A Newborn Sex-related Response to Hyperoxia. [Masters Thesis]. University of Toronto; 2012. Available from: http://hdl.handle.net/1807/33867

Colorado State University

10. Moore, Brandon L. Influence of anatomic valve conditions and coronary flow on aortic sinus hemodynamics.

Degree: PhD, Mechanical Engineering, 2016, Colorado State University

URL: http://hdl.handle.net/10217/170289

► Heart disease is the leading cause of death in the US, and aortic valve stenosis represents a significant portion of this disease. While the specific… (more)

▼ Heart disease is the leading cause of death in the US, and aortic valve stenosis represents a significant portion of this disease. While the specific causes of stenosis are not entirely clear, its development has been strongly linked to mechanical factors such as localized solid and fluid stresses and strains, especially on the aortic side of the valve leaflets. These mechanical cues can be tied to valvular hemodynamics, however the factors regulating these hemodynamics are relatively unknown. Therefore, the overarching hypothesis of this research is that aortic valve sinus hemodynamics are regulated by anatomic valve conditions and presence of coronary flow. This hypothesis is explored through three specific aims: 1) to develop methodologies for quantifying hemodynamics within the aortic sinuses, 2) to characterize the differences in native valve flow patterns that occur due to patient and sinus variability, and 3) to evaluate the hemodynamic impacts of different prosthetic aortic valve implantations. In this work, experimental methods have been developed to study a broad range of aortic valve conditions, and computational models were also employed to validate and enhance experimental findings. An in vitro setup is presented using a surgical bioprosthesis as a native aortic valve model, while additional valve implantations were also tested. Physiological pressures and flow rates were imposed across these valves via an in-house pumping loop, which included a novel coronary flow branch. Two-dimensional time-resolved particle image velocimetry (PIV) protocols were developed and employed to analyze sinus vorticity dynamics. Computationally, both 2D and 3D simulations were run in ANSYS Fluent to enhance experimental findings. Results from this research demonstrate that aortic sinus hemodynamics are indeed regulated by anatomic valve conditions and coronary flow. From a clinical perspective, average valve geometric parameters tend to produce hemodynamics that are least likely to initiate disease than those near the upper or lower anatomical limits. Coronary flow was likewise found to increase sinus velocities and shear stresses near the leaflets, which is also beneficial for valve health. The prosthetic valves tested – transcatheter and sutureless – both severely limited sinus perfusion, which could help explain an increased risk of thrombus formation in the transcatheter case and suggests similar risk for sutureless valves. These findings could help educate clinicians on proper courses of treatment based on patient-specific valve parameters, and could also provide useful information for engineers when designing new valve prostheses. Advisors/Committee Members: Dasi, Lakshmi Prasad (advisor), Gao, Xinfeng (advisor), Kirkpatrick, Allan (committee member), Orton, Christopher (committee member).

Subjects/Keywords: aortic valve; cardiovascular; heart; hemodynamics

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Moore, B. L. (2016). Influence of anatomic valve conditions and coronary flow on aortic sinus hemodynamics. (Doctoral Dissertation). Colorado State University. Retrieved from http://hdl.handle.net/10217/170289

Chicago Manual of Style (16^th Edition):

Moore, Brandon L. “Influence of anatomic valve conditions and coronary flow on aortic sinus hemodynamics.” 2016. Doctoral Dissertation, Colorado State University. Accessed July 24, 2019. http://hdl.handle.net/10217/170289.

MLA Handbook (7^th Edition):

Moore, Brandon L. “Influence of anatomic valve conditions and coronary flow on aortic sinus hemodynamics.” 2016. Web. 24 Jul 2019.

Vancouver:

Moore BL. Influence of anatomic valve conditions and coronary flow on aortic sinus hemodynamics. [Internet] [Doctoral dissertation]. Colorado State University; 2016. [cited 2019 Jul 24]. Available from: http://hdl.handle.net/10217/170289.

Council of Science Editors:

Moore BL. Influence of anatomic valve conditions and coronary flow on aortic sinus hemodynamics. [Doctoral Dissertation]. Colorado State University; 2016. Available from: http://hdl.handle.net/10217/170289

Rochester Institute of Technology

11. Varble, Nicole. A Hemodynamic investigation of a complete arteriovenous model of the arm, arteriovenous fistula, and distal revascularization and interval ligation.

Degree: Mechanical Engineering, 2011, Rochester Institute of Technology

URL: https://scholarworks.rit.edu/theses/5824

► One of the largest problems facing vascular surgeons today is malfunctioning arteriovenous fistulas (AVF) in patients on hemodialysis. A radial- cephalic AVF is a vessel… (more)

▼ One of the largest problems facing vascular surgeons today is malfunctioning arteriovenous fistulas (AVF) in patients on hemodialysis. A radial- cephalic AVF is a vessel in the arm that directs blood flow from the high pressure arteries to the low pressure veins and is put in place so blood can be withdrawn from a patient at a point where high volume blood flow occurs. After a period of maturation, the fistula often expands to adapt for the increase flow and can therefore be accessed repeatedly for hemodialysis. However, in a small percentage of cases, access related steal can lead to ischemia of the hand and threaten the patient with gangrene and amputation. This is a recognizable problem and is currently being treated with a method called Distal Revascularization and Interval Ligation (DRIL) in which a vast majority of cases see improved blood flow and pressure to the digits all while maintaining the AVF. The DRIL procedure has been widely accepted as an effective method to prevent the onset of steal, however the flow mechanisms and reasoning behind its success is not well understood. Thus far, attempts of explaining the procedure have been sparse and incomplete, often disregarding factors such as the compliance of the vessels and the pressures and flows on the venous side of the vasculature. To study this problem, a physical model was built using tubing with comparable resistances and compliances to that of native vessels. The native circulation was first built, including the venous side, which will provide a unique baseline for the study. An emphasis was placed on creating a system with physiologic pressures on both the arterial side and venous side. Once the model successfully represented the native blood flow, it was adapted for an AVF. Upon this adaptation, variations of radius, length, and position were tested. Furthermore, this model can easily be adapted to model hypertensive patients, much like those on hemodialysis and can offer additional insight as to if those patients are more susceptible to access related ischemia. Observations of pressures and flows led to a comprehensive study of the hemodynamics of the native arm circulation, an AVF and the DRIL procedure. When the model is integrated into the hemodynamic simulator loop, physiologic pressures have been produced in the arterial side of 125/55 mmHg and a damped waveform with a mean pressure of 18 mmHg was found on the venous side. Mean aortic flow was 4.7 L/min. Advisors/Committee Members: Day, Steven.

Subjects/Keywords: AVF; DRIL; Engineering; Hemodynamics; Vascular

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APA (6^th Edition):

Varble, N. (2011). A Hemodynamic investigation of a complete arteriovenous model of the arm, arteriovenous fistula, and distal revascularization and interval ligation. (Thesis). Rochester Institute of Technology. Retrieved from https://scholarworks.rit.edu/theses/5824

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Varble, Nicole. “A Hemodynamic investigation of a complete arteriovenous model of the arm, arteriovenous fistula, and distal revascularization and interval ligation.” 2011. Thesis, Rochester Institute of Technology. Accessed July 24, 2019. https://scholarworks.rit.edu/theses/5824.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Varble, Nicole. “A Hemodynamic investigation of a complete arteriovenous model of the arm, arteriovenous fistula, and distal revascularization and interval ligation.” 2011. Web. 24 Jul 2019.

Vancouver:

Varble N. A Hemodynamic investigation of a complete arteriovenous model of the arm, arteriovenous fistula, and distal revascularization and interval ligation. [Internet] [Thesis]. Rochester Institute of Technology; 2011. [cited 2019 Jul 24]. Available from: https://scholarworks.rit.edu/theses/5824.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Varble N. A Hemodynamic investigation of a complete arteriovenous model of the arm, arteriovenous fistula, and distal revascularization and interval ligation. [Thesis]. Rochester Institute of Technology; 2011. Available from: https://scholarworks.rit.edu/theses/5824

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Southern California

12. Henley, Brandon C. Parametric and nonparametric modeling of cerebral hemodynamics.

Degree: PhD, Biomedical Engineering, 2016, University of Southern California

URL: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/639702/rec/4913

► This manuscript focuses on the application of mathematical modeling to the study of cerebral hemodynamics. The central goal is to contribute to the pursuit of… (more)

▼ This manuscript focuses on the application of mathematical modeling to the study of cerebral hemodynamics. The central goal is to contribute to the pursuit of providing a reliable and practical approach to the management of clinical conditions relating to cerebral vascular and cognitive dysfunction. In particular, we study two fundamental processes of cerebral hemodynamics, cerebral autoregulation (CA) and vasomotor reactivity (VR) to CO₂ tension, using modeling techniques that provide quantitative information about the two processes. Quantitative assessment of CA and VR in humans serves as an important modeling goal, due to the observed association between cerebrovascular structure and function in the outcome of head injury, hypertension, stroke, vascular dementia, Alzheimer’s disease, and other forms of cognitive impairment. The availability of non-invasive measurements of relevant hemodynamic data has provided a means to obtain objective measures of CA and VR. It is believed that the relationship between time variations in cerebral perfusion pressure (CPP) and cerebral blood flow velocity can reflect relevant information about the status of CA in humans. In addition, it is well-known that CO₂ tension significantly influences the cerebral vasculature under physiological conditions, and the relationship between variations in CO₂ tension and cerebral perfusion is accepted as an approximation of the status of VR. Mathematical models of various forms have been employs as the methodological framework in which information about cerebral vascular status is summarized, analyzed, and interpreted. These models can be classified generally as “hypothesis-based” (or mechanistic) and “data-based” (or inductive). In the hypothesis-based approach, parametric models are constructed in the form of differential and/or algebraic equations from first hemodynamic principles in attempt to explicate the observed data. The main benefit of these models is the ability to derive physiological meaning, since the parameters which characterize the model are given meaning a priori. However, one important challenge is the virtually unavoidable oversimplification of the true depth of system, risking an incomplete and superficial picture of the actual system. This disadvantage can be supplemented by the use of inductive models, which are not hindered by simplifying assumptions about the system, but are instead obtained directly from measured data. Thus the data-based models are nonparametric in nature and their depth of the system depends on the richness of the data. These models are typically much easier to obtain (using a computer), and knowledge about the system is not required. However, the challenge of the data-based approach is the difficulty in achieving clear physiological interpretation for the model, which says nothing explicitly about the system. Advisors/Committee Members: Marmarelis, Vasilis (Committee Chair), Nation, Daniel (Committee Member), Khoo, Michael (Committee Member), King, Kevin (Committee Member).

Subjects/Keywords: cerebral autoregulation; vasomotor reactivity; hemodynamics

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Henley, B. C. (2016). Parametric and nonparametric modeling of cerebral hemodynamics. (Doctoral Dissertation). University of Southern California. Retrieved from http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/639702/rec/4913

Chicago Manual of Style (16^th Edition):

Henley, Brandon C. “Parametric and nonparametric modeling of cerebral hemodynamics.” 2016. Doctoral Dissertation, University of Southern California. Accessed July 24, 2019. http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/639702/rec/4913.

MLA Handbook (7^th Edition):

Henley, Brandon C. “Parametric and nonparametric modeling of cerebral hemodynamics.” 2016. Web. 24 Jul 2019.

Vancouver:

Henley BC. Parametric and nonparametric modeling of cerebral hemodynamics. [Internet] [Doctoral dissertation]. University of Southern California; 2016. [cited 2019 Jul 24]. Available from: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/639702/rec/4913.

Council of Science Editors:

Henley BC. Parametric and nonparametric modeling of cerebral hemodynamics. [Doctoral Dissertation]. University of Southern California; 2016. Available from: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/639702/rec/4913

Université Catholique de Louvain

13. De Magnee, Catherine. Liver and systemic hemodynamics in cirrhotic children : contributions to the physiopathology and to the surgical algorithm in pediatric liver transplantation.

Degree: 2018, Université Catholique de Louvain

URL: http://hdl.handle.net/2078.1/199568

►

Liver and systemic hemodynamics are altered in cirrhotic adults. This work attempts to determine if these hemodynamic parameters are perturbed in cirrhotic children as in… (more)

Subjects/Keywords: Liver hemodynamics; Children; Cirrhosis; Pediatric liver transplantation; Systemic hemodynamics

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APA (6^th Edition):

De Magnee, C. (2018). Liver and systemic hemodynamics in cirrhotic children : contributions to the physiopathology and to the surgical algorithm in pediatric liver transplantation. (Thesis). Université Catholique de Louvain. Retrieved from http://hdl.handle.net/2078.1/199568

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

De Magnee, Catherine. “Liver and systemic hemodynamics in cirrhotic children : contributions to the physiopathology and to the surgical algorithm in pediatric liver transplantation.” 2018. Thesis, Université Catholique de Louvain. Accessed July 24, 2019. http://hdl.handle.net/2078.1/199568.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

De Magnee, Catherine. “Liver and systemic hemodynamics in cirrhotic children : contributions to the physiopathology and to the surgical algorithm in pediatric liver transplantation.” 2018. Web. 24 Jul 2019.

Vancouver:

De Magnee C. Liver and systemic hemodynamics in cirrhotic children : contributions to the physiopathology and to the surgical algorithm in pediatric liver transplantation. [Internet] [Thesis]. Université Catholique de Louvain; 2018. [cited 2019 Jul 24]. Available from: http://hdl.handle.net/2078.1/199568.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

De Magnee C. Liver and systemic hemodynamics in cirrhotic children : contributions to the physiopathology and to the surgical algorithm in pediatric liver transplantation. [Thesis]. Université Catholique de Louvain; 2018. Available from: http://hdl.handle.net/2078.1/199568

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Alberta

14. Urquhart, Gayle. Timing of hemodynamic pressure measurements and thermodilutional cardiac outputs on derived hemodynamic parameters.

Degree: Master of Nursing, Faculty of Nursing, 1999, University of Alberta

URL: https://era.library.ualberta.ca/files/kp78gj50q

Subjects/Keywords: Cardiac output.; Hemodynamics.

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APA (6^th Edition):

Urquhart, G. (1999). Timing of hemodynamic pressure measurements and thermodilutional cardiac outputs on derived hemodynamic parameters. (Masters Thesis). University of Alberta. Retrieved from https://era.library.ualberta.ca/files/kp78gj50q

Chicago Manual of Style (16^th Edition):

Urquhart, Gayle. “Timing of hemodynamic pressure measurements and thermodilutional cardiac outputs on derived hemodynamic parameters.” 1999. Masters Thesis, University of Alberta. Accessed July 24, 2019. https://era.library.ualberta.ca/files/kp78gj50q.

MLA Handbook (7^th Edition):

Urquhart, Gayle. “Timing of hemodynamic pressure measurements and thermodilutional cardiac outputs on derived hemodynamic parameters.” 1999. Web. 24 Jul 2019.

Vancouver:

Urquhart G. Timing of hemodynamic pressure measurements and thermodilutional cardiac outputs on derived hemodynamic parameters. [Internet] [Masters thesis]. University of Alberta; 1999. [cited 2019 Jul 24]. Available from: https://era.library.ualberta.ca/files/kp78gj50q.

Council of Science Editors:

Urquhart G. Timing of hemodynamic pressure measurements and thermodilutional cardiac outputs on derived hemodynamic parameters. [Masters Thesis]. University of Alberta; 1999. Available from: https://era.library.ualberta.ca/files/kp78gj50q

Georgia Tech

15. Rathan, Swetha. Aortic valve mechanobiology- role of altered hemodynamics in mediating aortic valve inflammation and calcification.

Degree: PhD, Chemical and Biomolecular Engineering, 2016, Georgia Tech

URL: http://hdl.handle.net/1853/58144

► Calcific aortic valve (AV) disease is a strong risk factor for cardiovascular related deaths and is a significant source of mortality worldwide, with the number… (more)

▼ Calcific aortic valve (AV) disease is a strong risk factor for cardiovascular related deaths and is a significant source of mortality worldwide, with the number of patients requiring AV surgery expected to increase from 250,000 to 850,000 by 2050. However, the molecular mechanisms underlying AV disease have not been well studied or understood. Further, identification of biomarkers that can be used to detect early stage AV disease is also understudied but vital to successfully preventing and/or treating AV disease. It was hypothesized that sclerosis, inflammation and calcification preferentially occurs in the fibrosa compared to the ventricularis due to differential gene expression and oscillatory shear stress. Freshly isolated porcine AV leaflets and an ex vivo shear stress bioreactor was used to test this hypothesis. The low magnitude oscillatory shear stress (OS) appeared to predispose fibrosa to side-dependent calcification via increasing collagen turnover (Col1a1), and thickening of the extracellular matrix (ECM) (fibrosis) and decreasing the expression of genes that protect endothelial function (Klf4 and Enos). The unidirectional pulsatile shear, LS, however, preserved the ECM and gene expression in the ventricularis. The involvement of miRNAs in OS mediated AV pathogenesis was also investigated in a shear- and side-dependent manner. The miR-214 was found to play a role in this OS induced pathogenesis in fibrosa but not ventricularis. Using an ex vivo miRNA silencing protocol, anti-miRNA was delivered to both endothelial and interstitial cells of the AV tissue without compromising the cell viability. Silencing of miR-214 showed that the OS induced pathology in the fibrosa is likely to be mediated via miR-214, klf4 and Tgfβ1 dependent pathway that can lead to AV fibrosis, endothelial-to-mesenchymal transition and eventually sclerosis. The miR-214, however, did not play a role in shear-induced inflammation and calcification. The miR-214, as such, is likely to play a key role in the early onset of side- and shear- dependent AV disease and has a potential to serve as a disease biomarker. Further, an ex vivo AV calcification model was also developed to understand the role of endogenous pro- and anti-calcification factors, such as inorganic pyrophosphate, orthophosphate, and alkaline phosphatase. The functional studies carried out in this dissertation aim to link the mechanosensitive miRNAs to the genes involved in inflammation, endothelial-to-mesenchymal transition, and cell apoptosis etc, which eventually causes AV leaflets to calcify. Thus improved understanding of AV disease mechanisms under different hemodynamic conditions will enable us to improve the design of tissue-engineered valves and develop non-surgical treatment options. Advisors/Committee Members: Yoganathan, Ajit P. (advisor), Jo, Hanjoong (committee member), Taylor, W. Robert (committee member), Champion, Julie A. (committee member), Nerem, Robert M. (committee member).

Subjects/Keywords: Aortic valve; Hemodynamics; Mechanobiology; MicroRNA; Calcification

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Rathan, S. (2016). Aortic valve mechanobiology- role of altered hemodynamics in mediating aortic valve inflammation and calcification. (Doctoral Dissertation). Georgia Tech. Retrieved from http://hdl.handle.net/1853/58144

Chicago Manual of Style (16^th Edition):

Rathan, Swetha. “Aortic valve mechanobiology- role of altered hemodynamics in mediating aortic valve inflammation and calcification.” 2016. Doctoral Dissertation, Georgia Tech. Accessed July 24, 2019. http://hdl.handle.net/1853/58144.

MLA Handbook (7^th Edition):

Rathan, Swetha. “Aortic valve mechanobiology- role of altered hemodynamics in mediating aortic valve inflammation and calcification.” 2016. Web. 24 Jul 2019.

Vancouver:

Rathan S. Aortic valve mechanobiology- role of altered hemodynamics in mediating aortic valve inflammation and calcification. [Internet] [Doctoral dissertation]. Georgia Tech; 2016. [cited 2019 Jul 24]. Available from: http://hdl.handle.net/1853/58144.

Council of Science Editors:

Rathan S. Aortic valve mechanobiology- role of altered hemodynamics in mediating aortic valve inflammation and calcification. [Doctoral Dissertation]. Georgia Tech; 2016. Available from: http://hdl.handle.net/1853/58144

University of Zambia

16. Mubyana, Maswabi Mukela. Some aspects of hemodynamics on blood flow .

Degree: 2012, University of Zambia

URL: http://hdl.handle.net/123456789/1688

Subjects/Keywords: Blood flow.; Hemodynamics.

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APA (6^th Edition):

Mubyana, M. M. (2012). Some aspects of hemodynamics on blood flow . (Thesis). University of Zambia. Retrieved from http://hdl.handle.net/123456789/1688

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Mubyana, Maswabi Mukela. “Some aspects of hemodynamics on blood flow .” 2012. Thesis, University of Zambia. Accessed July 24, 2019. http://hdl.handle.net/123456789/1688.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Mubyana, Maswabi Mukela. “Some aspects of hemodynamics on blood flow .” 2012. Web. 24 Jul 2019.

Vancouver:

Mubyana MM. Some aspects of hemodynamics on blood flow . [Internet] [Thesis]. University of Zambia; 2012. [cited 2019 Jul 24]. Available from: http://hdl.handle.net/123456789/1688.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Mubyana MM. Some aspects of hemodynamics on blood flow . [Thesis]. University of Zambia; 2012. Available from: http://hdl.handle.net/123456789/1688

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Gothenburg / Göteborgs Universitet

17. Malmcrona, Raoul, 1931-. Haemodynamics in myocardial infarction.

Degree: 1964, University of Gothenburg / Göteborgs Universitet

URL: http://hdl.handle.net/2077/12938

Subjects/Keywords: Myocardial infarction; hemodynamics

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APA (6^th Edition):

Malmcrona, Raoul, 1. (1964). Haemodynamics in myocardial infarction. (Thesis). University of Gothenburg / Göteborgs Universitet. Retrieved from http://hdl.handle.net/2077/12938

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Malmcrona, Raoul, 1931-. “Haemodynamics in myocardial infarction.” 1964. Thesis, University of Gothenburg / Göteborgs Universitet. Accessed July 24, 2019. http://hdl.handle.net/2077/12938.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Malmcrona, Raoul, 1931-. “Haemodynamics in myocardial infarction.” 1964. Web. 24 Jul 2019.

Vancouver:

Malmcrona, Raoul 1. Haemodynamics in myocardial infarction. [Internet] [Thesis]. University of Gothenburg / Göteborgs Universitet; 1964. [cited 2019 Jul 24]. Available from: http://hdl.handle.net/2077/12938.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Malmcrona, Raoul 1. Haemodynamics in myocardial infarction. [Thesis]. University of Gothenburg / Göteborgs Universitet; 1964. Available from: http://hdl.handle.net/2077/12938

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Gothenburg / Göteborgs Universitet

18. Sivertsson, Ramon, 1936-. The hemodynamic importance of structural vascular changes in essential hypertension.

Degree: 1970, University of Gothenburg / Göteborgs Universitet

URL: http://hdl.handle.net/2077/14140

Subjects/Keywords: Blood vessels; Hemodynamics

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APA (6^th Edition):

Sivertsson, Ramon, 1. (1970). The hemodynamic importance of structural vascular changes in essential hypertension. (Thesis). University of Gothenburg / Göteborgs Universitet. Retrieved from http://hdl.handle.net/2077/14140

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Sivertsson, Ramon, 1936-. “The hemodynamic importance of structural vascular changes in essential hypertension.” 1970. Thesis, University of Gothenburg / Göteborgs Universitet. Accessed July 24, 2019. http://hdl.handle.net/2077/14140.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Sivertsson, Ramon, 1936-. “The hemodynamic importance of structural vascular changes in essential hypertension.” 1970. Web. 24 Jul 2019.

Vancouver:

Sivertsson, Ramon 1. The hemodynamic importance of structural vascular changes in essential hypertension. [Internet] [Thesis]. University of Gothenburg / Göteborgs Universitet; 1970. [cited 2019 Jul 24]. Available from: http://hdl.handle.net/2077/14140.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Sivertsson, Ramon 1. The hemodynamic importance of structural vascular changes in essential hypertension. [Thesis]. University of Gothenburg / Göteborgs Universitet; 1970. Available from: http://hdl.handle.net/2077/14140

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

19. Vedula, Vijay. Image based computational modeling of intracardiac flows.

Degree: 2015, Johns Hopkins University

URL: http://jhir.library.jhu.edu/handle/1774.2/37858

► With continuous advancements in four-dimensional medical imaging technologies, increasing computational speeds, and widespread availability of high performance computing facilities, computational modeling of intracardiac flows is… (more)

▼ With continuous advancements in four-dimensional medical imaging technologies, increasing computational speeds, and widespread availability of high performance computing facilities, computational modeling of intracardiac flows is becoming increasingly viable and has the potential to become a powerful non-invasive diagnostic tool for the diagnosis and treatment of cardiovascular disease. The motive of the current study is to develop a modeling framework that facilitates image-based analysis of intracardiac flows in health as well as disease and to use this framework to gain fundamental insights into intracardiac hemodynamics. A procedure is developed for constructing computational fluid dynamics (CFD) – ready models from in vivo imaging data. The key components of this procedure are the registration and segmentation of the 4D data for several (~20) key frames, template based mapping to ensure surface grid conformality and high-fidelity simulations using a sharp-interface immersed boundary solver. A physiologically representative, kinematic model of the mitral valve is also developed for use in these simulations. As a precursor, a comprehensive quantitative validation of the flow solver is performed using experimental data in a simple model of the left ventricle. A quantitative comparison of the phase-averaged velocity and vorticity fields between the simulation and the experiment shows a reasonable agreement. The detailed assessment of this comparison is used to identify and discuss the key challenges and uncertainties associated in conducting such a validation study. The vast majority of computational investigations of intracardiac flows have focused either on the left or the right ventricles while the corresponding atria were modeled in highly simplistic ways. However, the impact of this simplification on the hemodynamics of the ventricular filling has not been clearly understood. Additionally, the surface of the ventricle has been assumed to be smooth although it is well known that the left ventricle is highly corrugated with surface protrusions or trabeculae and papillary muscles extending deep into the ventricular cavity. Hence, separate studies were conducted to understand the effect of complex atrial flows on the intraventricular flow development and also to understand and quantify the impact of the trabeculae and papillary muscles on ventricular hemodynamics Results indicate that the trabeculae and papillary muscles significantly impact ventricular flow resulting in a deeper penetration of the mitral jet into the ventricle during filling. These anatomical features are also found to produce a “squeezing” effect that enhances apical washout. It is also demonstrated that the complex flow dynamics developed inside the left atrium have minimal influence on the flow inside the left ventricle, which is primarily governed by the mitral valve leaflets configuration. The complex vortical structures inside the left atrium are rapidly dissipated due to the complex interaction of multiple vortex rings leading to breakup,… Advisors/Committee Members: Mittal, Rajat (advisor).

Subjects/Keywords: Cardiac hemodynamics; computational modeling; immersed boundary methods

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APA (6^th Edition):

Vedula, V. (2015). Image based computational modeling of intracardiac flows. (Thesis). Johns Hopkins University. Retrieved from http://jhir.library.jhu.edu/handle/1774.2/37858

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Vedula, Vijay. “Image based computational modeling of intracardiac flows.” 2015. Thesis, Johns Hopkins University. Accessed July 24, 2019. http://jhir.library.jhu.edu/handle/1774.2/37858.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Vedula, Vijay. “Image based computational modeling of intracardiac flows.” 2015. Web. 24 Jul 2019.

Vancouver:

Vedula V. Image based computational modeling of intracardiac flows. [Internet] [Thesis]. Johns Hopkins University; 2015. [cited 2019 Jul 24]. Available from: http://jhir.library.jhu.edu/handle/1774.2/37858.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Vedula V. Image based computational modeling of intracardiac flows. [Thesis]. Johns Hopkins University; 2015. Available from: http://jhir.library.jhu.edu/handle/1774.2/37858

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Cornell University

20. Nguyen, John. Femtosecond Laser Pulses To Model And Treat Brain Diseases .

Degree: 2011, Cornell University

URL: http://hdl.handle.net/1813/30763

► Tightly focusing femtosecond laser pulses into bulk media, such as brain tissue, can generate high intensities within the focal volume. With sufficient laser energies, nonlinear… (more)

▼ Tightly focusing femtosecond laser pulses into bulk media, such as brain tissue, can generate high intensities within the focal volume. With sufficient laser energies, nonlinear absorption of femtosecond laser pulses by the media can take place. This thesis takes advantages of these nonlinear processes to image the cortical vasculature in live anesthetized rodent, and induce localized tissue disruption. We used two-photon excited fluorescence (2PEF) microscopy to image fluorescently labeled cortical vasculature in vivo. In this technique, two-photons are simultaneously absorbed to generate fluorescence that is localized within the focal volume, where intensity is greatest. Scanning the focus enables three-dimensional imaging since out-of-focus fluorescence is not generated. Higher-order nonlinear absorption processes that lead to plasma and cavitation bubble formation are used to induce localized tissue disruption. Together these nonlinear tools enable fine-detailed studies of the cortical vasculature and precise ablation of tissue. To understand the potential role of small venule strokes in the development of cognitive disorders, we investigated the blood flow and vascular effects in individual vessels after inducing single venule occlusions using femtosecond laser ablation. To better understand the blood flow and metabolic responses during an epileptic seizure, we use a several optical techniques to investigate the neurovascular and neurometabolic activity during pre-ictal and ictal phases of focal seizures. Using 2PEF microscopy we reveal the presence of vasoconstriction in arterioles surrounding the focus prior to seizure onset. The deposition of energy within the focal volume can also used to make incisions in bulk brain to disrupt tissue. Using our laser scalpel, we produced sub-surface cortical incisions and characterized the cut width and depth as a function of different laser energies. We then employed this cutting technique to determine the efficacy of sub-surface cuts in stopping seizure propagation. We then showcased a technique to produce welds at the unexposed interface between two pieces of glass and characterized their size as a function of multiple experimental parameters. Joint strength of the fused glass was tested in addition to investigating the changes in optical properties induced by the weld. Lastly, future experiments and advantages of nonlinear optical techniques are discussed. Advisors/Committee Members: Fetcho, Joseph R. (committeeMember), Zipfel, Warren R. (committeeMember).

Subjects/Keywords: two-photon microscopy; femtosecond laser ablation; hemodynamics

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Nguyen, J. (2011). Femtosecond Laser Pulses To Model And Treat Brain Diseases . (Thesis). Cornell University. Retrieved from http://hdl.handle.net/1813/30763

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Nguyen, John. “Femtosecond Laser Pulses To Model And Treat Brain Diseases .” 2011. Thesis, Cornell University. Accessed July 24, 2019. http://hdl.handle.net/1813/30763.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Nguyen, John. “Femtosecond Laser Pulses To Model And Treat Brain Diseases .” 2011. Web. 24 Jul 2019.

Vancouver:

Nguyen J. Femtosecond Laser Pulses To Model And Treat Brain Diseases . [Internet] [Thesis]. Cornell University; 2011. [cited 2019 Jul 24]. Available from: http://hdl.handle.net/1813/30763.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Nguyen J. Femtosecond Laser Pulses To Model And Treat Brain Diseases . [Thesis]. Cornell University; 2011. Available from: http://hdl.handle.net/1813/30763

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Virginia Tech

21. Mack, Elizabeth. Hemodynamic Optimization of a Passive Assist Total Cavopulmonary Connector for ages 1-20.

Degree: MS, Biomedical Engineering and Mechanics, 2018, Virginia Tech

URL: http://hdl.handle.net/10919/84450

► Currently, the surgical procedure followed by the majority of cardiac surgeons to address a nonfunctioning right portion of the heart is the Fontan procedure, which… (more)

▼ Currently, the surgical procedure followed by the majority of cardiac surgeons to address a nonfunctioning right portion of the heart is the Fontan procedure, which connects the two major inflow venous structures from the right side of the heart directly to the two major outflow venous structures, bypassing the right nonfunctioning right portion of the heart. However, this is not the most efficient configuration from a fluid flow perspective. The goal of this study is to develop a patient-specific 4-way connector to bypass the nonfunctioning right side of the heart and aid in overall circulation. Just like the Fontan procdure, the 4-way connector was intended to channel the blood flow from the two main inflow venous structures directly to the two major outflow venous structures. By creating a connector with proper fluid flow characteristics, one can control the flow interactions between the two inflows and streamline the flow towards the two outflow venous structures. In this study, the focus was on creating a system that could identify the optimal configuration for the 4-way connector for patients from 1-20 years of age. A platform was created in a modeling and simulation program, called ANSYS, that utilized the design of experiments (DOE) function to minimize power-loss and the likelihood of blood damage in the connector based on connector geometries. A CFD model was created to simulate the blood flow through the connector. Then the geometry of the bypass connector was parameterized for the DOE process. The selected design parameters included inlet and outlet diameters, radius at the intersection, and length of the connector pathways. The chosen range for each geometric parameter was based on the relative size of the patient’s arteries found in the literature. It was confirmed that as the patient’s age and artery size change, the optimal size and shape of the connector also changes. From the results of the first study showed a very decreasing relationship between the opening radius and the corner radius as the opening radius increased in size. It was also found that power losses within the connector decrease and average and maximum blood traversal time through the connector increased for increasing opening radius. A follow up study was conducted to try to reduce or negate a consistent recirculation area found at the center of the connectors. To accomplish this a flow diverter was added to the center of the connector and optimized for each of the connectors found for the age groups used. From this study, it was found that the diverter did negate the recirculation area form the centers of the connectors. A separate Blood Damage Index (BDI) study was also run on this optimized connector with a diverter, the optimized connectors from the first study and a baseline connector. This showed a decrease in BDI from the venous structure with the larger inlet flow for the optimized versions of the connector compared to the baseline geometries. This information could be used to create a more specific relationship between the… Advisors/Committee Members: Untaroiu, Alexandrina (committeechair), O'Brien, Walter N. (committee member), Staples, Anne (committee member).

Subjects/Keywords: Computational Fluid Dynamics; Heart; Hemodynamics; Biomedical

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APA (6^th Edition):

Mack, E. (2018). Hemodynamic Optimization of a Passive Assist Total Cavopulmonary Connector for ages 1-20. (Masters Thesis). Virginia Tech. Retrieved from http://hdl.handle.net/10919/84450

Chicago Manual of Style (16^th Edition):

Mack, Elizabeth. “Hemodynamic Optimization of a Passive Assist Total Cavopulmonary Connector for ages 1-20.” 2018. Masters Thesis, Virginia Tech. Accessed July 24, 2019. http://hdl.handle.net/10919/84450.

MLA Handbook (7^th Edition):

Mack, Elizabeth. “Hemodynamic Optimization of a Passive Assist Total Cavopulmonary Connector for ages 1-20.” 2018. Web. 24 Jul 2019.

Vancouver:

Mack E. Hemodynamic Optimization of a Passive Assist Total Cavopulmonary Connector for ages 1-20. [Internet] [Masters thesis]. Virginia Tech; 2018. [cited 2019 Jul 24]. Available from: http://hdl.handle.net/10919/84450.

Council of Science Editors:

Mack E. Hemodynamic Optimization of a Passive Assist Total Cavopulmonary Connector for ages 1-20. [Masters Thesis]. Virginia Tech; 2018. Available from: http://hdl.handle.net/10919/84450

Michigan State University

22. Loutzenhiser, Rodger Dale. Relation of angiotensin II to the control of autoregulation of renal hemodynamics in the dog.

Degree: MS, Dept. of Physiology, 1971, Michigan State University

URL: http://etd.lib.msu.edu/islandora/object/etd:10155

Subjects/Keywords: Kidneys; Hemodynamics; Dogs

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APA (6^th Edition):

Loutzenhiser, R. D. (1971). Relation of angiotensin II to the control of autoregulation of renal hemodynamics in the dog. (Masters Thesis). Michigan State University. Retrieved from http://etd.lib.msu.edu/islandora/object/etd:10155

Chicago Manual of Style (16^th Edition):

Loutzenhiser, Rodger Dale. “Relation of angiotensin II to the control of autoregulation of renal hemodynamics in the dog.” 1971. Masters Thesis, Michigan State University. Accessed July 24, 2019. http://etd.lib.msu.edu/islandora/object/etd:10155.

MLA Handbook (7^th Edition):

Loutzenhiser, Rodger Dale. “Relation of angiotensin II to the control of autoregulation of renal hemodynamics in the dog.” 1971. Web. 24 Jul 2019.

Vancouver:

Loutzenhiser RD. Relation of angiotensin II to the control of autoregulation of renal hemodynamics in the dog. [Internet] [Masters thesis]. Michigan State University; 1971. [cited 2019 Jul 24]. Available from: http://etd.lib.msu.edu/islandora/object/etd:10155.

Council of Science Editors:

Loutzenhiser RD. Relation of angiotensin II to the control of autoregulation of renal hemodynamics in the dog. [Masters Thesis]. Michigan State University; 1971. Available from: http://etd.lib.msu.edu/islandora/object/etd:10155

University of Wisconsin – La Cross

23. Motto, Rosemary E. Comparison of the Cardiovascular hemodynamic adaptations of angina pectoris to "second wind".

Degree: 1979, University of Wisconsin – La Cross

URL: http://digital.library.wisc.edu/1793/48852

► Heart rate (HR), systolic blood pressure (SBP), diastolic blood pressure (DBP ), rate-pressure product (RPP), the mean maximal MET level and the mean maximal painfree… (more)

Subjects/Keywords: Hemodynamics; Angina pectoris

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APA (6^th Edition):

Motto, R. E. (1979). Comparison of the Cardiovascular hemodynamic adaptations of angina pectoris to "second wind". (Thesis). University of Wisconsin – La Cross. Retrieved from http://digital.library.wisc.edu/1793/48852

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Motto, Rosemary E. “Comparison of the Cardiovascular hemodynamic adaptations of angina pectoris to "second wind".” 1979. Thesis, University of Wisconsin – La Cross. Accessed July 24, 2019. http://digital.library.wisc.edu/1793/48852.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Motto, Rosemary E. “Comparison of the Cardiovascular hemodynamic adaptations of angina pectoris to "second wind".” 1979. Web. 24 Jul 2019.

Vancouver:

Motto RE. Comparison of the Cardiovascular hemodynamic adaptations of angina pectoris to "second wind". [Internet] [Thesis]. University of Wisconsin – La Cross; 1979. [cited 2019 Jul 24]. Available from: http://digital.library.wisc.edu/1793/48852.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Motto RE. Comparison of the Cardiovascular hemodynamic adaptations of angina pectoris to "second wind". [Thesis]. University of Wisconsin – La Cross; 1979. Available from: http://digital.library.wisc.edu/1793/48852

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Wisconsin – La Cross

24. Haugen, Alyson R. Screening for psychosocial distress in patients with hematological malignancies and identifying specific factors associated with distress throughout phase of disease.

Degree: 2011, University of Wisconsin – La Cross

URL: http://digital.library.wisc.edu/1793/57136

► The diagnosis of a hematological malignancy and its treatment can lead to symptoms and problems that affect quality of life. An important task of the… (more)

Subjects/Keywords: Cancer, Psychological aspects; Stress (Physiology); Hemodynamics

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APA (6^th Edition):

Haugen, A. R. (2011). Screening for psychosocial distress in patients with hematological malignancies and identifying specific factors associated with distress throughout phase of disease. (Thesis). University of Wisconsin – La Cross. Retrieved from http://digital.library.wisc.edu/1793/57136

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Haugen, Alyson R. “Screening for psychosocial distress in patients with hematological malignancies and identifying specific factors associated with distress throughout phase of disease.” 2011. Thesis, University of Wisconsin – La Cross. Accessed July 24, 2019. http://digital.library.wisc.edu/1793/57136.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Haugen, Alyson R. “Screening for psychosocial distress in patients with hematological malignancies and identifying specific factors associated with distress throughout phase of disease.” 2011. Web. 24 Jul 2019.

Vancouver:

Haugen AR. Screening for psychosocial distress in patients with hematological malignancies and identifying specific factors associated with distress throughout phase of disease. [Internet] [Thesis]. University of Wisconsin – La Cross; 2011. [cited 2019 Jul 24]. Available from: http://digital.library.wisc.edu/1793/57136.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Haugen AR. Screening for psychosocial distress in patients with hematological malignancies and identifying specific factors associated with distress throughout phase of disease. [Thesis]. University of Wisconsin – La Cross; 2011. Available from: http://digital.library.wisc.edu/1793/57136

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of South Florida

25. Zhang, Jie. Glomerular Hyperfiltration and Hypertension in Diabetes.

Degree: 2017, University of South Florida

URL: https://scholarcommons.usf.edu/etd/7455

► In the present study, we investigated the pathophysiological mechanisms of the hemodynamic alteration in diabetes. Glomerular hyperfiltration occurs in the early stage of diabetes mellitus… (more)

Subjects/Keywords: Diabetes,; Hyperfiltration; Hypertension; Renal Hemodynamics; Physiology

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APA (6^th Edition):

Zhang, J. (2017). Glomerular Hyperfiltration and Hypertension in Diabetes. (Thesis). University of South Florida. Retrieved from https://scholarcommons.usf.edu/etd/7455

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Zhang, Jie. “Glomerular Hyperfiltration and Hypertension in Diabetes.” 2017. Thesis, University of South Florida. Accessed July 24, 2019. https://scholarcommons.usf.edu/etd/7455.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Zhang, Jie. “Glomerular Hyperfiltration and Hypertension in Diabetes.” 2017. Web. 24 Jul 2019.

Vancouver:

Zhang J. Glomerular Hyperfiltration and Hypertension in Diabetes. [Internet] [Thesis]. University of South Florida; 2017. [cited 2019 Jul 24]. Available from: https://scholarcommons.usf.edu/etd/7455.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Zhang J. Glomerular Hyperfiltration and Hypertension in Diabetes. [Thesis]. University of South Florida; 2017. Available from: https://scholarcommons.usf.edu/etd/7455

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Rochester

26. Saager, Rolf B. (1975 - ). Corrected near-infrared spectroscopy, C-NIRS : an optical system for extracting hemodynamic signatures unique to the brain.

Degree: PhD, 2009, University of Rochester

URL: http://hdl.handle.net/1802/6436

► We propose a method, dubbed Corrected near-infrared Spectroscopy (C-NIRS), to isolate absorption trends confined to the lower layer of a two-layer turbid medium, as is… (more)

▼ We propose a method, dubbed Corrected near-infrared Spectroscopy (C-NIRS), to isolate absorption trends confined to the lower layer of a two-layer turbid medium, as is desired in near-infrared spectroscopy (NIRS) of cerebral hemodynamics. The theory behind the operation of this method has been developed and discussed. Several two-layer Monte-Carlo simulations of NIRS time series were generated using a physiologically relevant range of optical properties. Initial results show that by measuring absorption trends at two source-detector separations and performing a least-squares fit of one to the other, the processed residual signal strongly resembles the simulated absorption properties unique to the bottom-layer. Through this approach, it has been demonstrated that fitting coefficients can be estimated without any <I>a priori</I> knowledge of the optical properties present in the model. An analytical approximation for the least-squares coefficient provides physical insight into the nature of errors and suggests ways to reduce them. Next, a multi-detector, continuous wave, near-infrared spectroscopy system has been developed to examine whether the hemodynamics of the scalp and brain in adults contain significant layer-like hemodynamic trends. NIRS measurements were made using contrasting geometries, one with four detectors equidistant from a source 33 mm away, and one with detectors collinear with the source (5–33 mm away). When NIRS time series were acquired over the prefrontal cortex from resting adults using both geometries, variations among the time series were consistent with a substantially homogeneous two-layer model (<I>p</I> < 0.001) and inconsistent with one dominated by heterogeneities. Additionally, when time series measured 5 mm from the source were subtracted from corresponding 33 mm signals via a least-squares algorithm, 60% of the hemoglobin changes were on average removed. These results suggest that hemodynamic trends present in the scalp can contribute significantly to NIRS measurements, and that attempts to reduce this noise by subtracting a simultaneous near-channel measurement using a two-layer model are justified. Finally, a full implementation of the C-NIRS method in a functional study was evaluated on a small human subject population. For this study, a multi-channel instrument designed for regional mapping of the head (coverage area of 4X8 cm) was developed and will be discussed in detail. C-NIRS was directly compared with data processed under the standard continuous wave (CW) NIRS method through the use of two performance metrics. C-NIRS was consistently able to produce functionally specific hemodynamic responses which were cleaner (in terms of signal-to-noise) and more robust (in terms of statistical significance) than those produced by NIRS in each individual subject. Based on the results of this study, it was noted that the magnitude of improvement varied greatly from subject to subject. The scope of this thesis was to develop an instrument based on a simple, yet physiologically…

Subjects/Keywords: Near infrared spectroscopy; Optics; Functional imaging; Hemodynamics

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APA (6^th Edition):

Saager, R. B. (. -. ). (2009). Corrected near-infrared spectroscopy, C-NIRS : an optical system for extracting hemodynamic signatures unique to the brain. (Doctoral Dissertation). University of Rochester. Retrieved from http://hdl.handle.net/1802/6436

Chicago Manual of Style (16^th Edition):

Saager, Rolf B (1975 - ). “Corrected near-infrared spectroscopy, C-NIRS : an optical system for extracting hemodynamic signatures unique to the brain.” 2009. Doctoral Dissertation, University of Rochester. Accessed July 24, 2019. http://hdl.handle.net/1802/6436.

MLA Handbook (7^th Edition):

Saager, Rolf B (1975 - ). “Corrected near-infrared spectroscopy, C-NIRS : an optical system for extracting hemodynamic signatures unique to the brain.” 2009. Web. 24 Jul 2019.

Vancouver:

Saager RB(-). Corrected near-infrared spectroscopy, C-NIRS : an optical system for extracting hemodynamic signatures unique to the brain. [Internet] [Doctoral dissertation]. University of Rochester; 2009. [cited 2019 Jul 24]. Available from: http://hdl.handle.net/1802/6436.

Council of Science Editors:

Saager RB(-). Corrected near-infrared spectroscopy, C-NIRS : an optical system for extracting hemodynamic signatures unique to the brain. [Doctoral Dissertation]. University of Rochester; 2009. Available from: http://hdl.handle.net/1802/6436

Penn State University

27. Winder, Aaron. Origins of Spontaneous Hemodynamic Signals in the Awake Brain.

Degree: 2017, Penn State University

URL: https://etda.libraries.psu.edu/catalog/14417atw155

► Cerebral blood flow is dynamically regulated through signaling from active neural populations. This neurovascular coupling allows the brain to satisfy its metabolic needs and enables… (more)

▼ Cerebral blood flow is dynamically regulated through signaling from active neural populations. This neurovascular coupling allows the brain to satisfy its metabolic needs and enables the use of non-invasive imaging techniques, such as fMRI, to study brain function through hemodynamic measurements. In particular, hemodynamic fluctuations, which occur in the absence of a task or overt sensory stimulation, are used to infer ongoing local neural activity and study intrinsic functional brain connectivity. However, the neural underpinnings of these spontaneous hemodynamic signals are not clear.We tested how well spontaneous hemodynamic signals correspond to local neural activity by making simultaneous cerebral blood volume (CBV) and electrophysiological measurements from the somatosensory cortex of awake, head-fixed mice during periods of rest, sensory stimulation, and volitional movement. Large spontaneous CBV changes in the absence of sensory input were primarily driven by volitional whisker and body movements, indicating that unmonitored behaviors could contribute to hemodynamic variance in resting state neuroimaging studies. We then quantified neurovascular coupling as the transfer function between measured neural activity and CBV. We showed that the temporal dynamics of the vascular response to increased neural activity were similar across behavioral states.However, individual CBV changes were weakly predictive of the corresponding local neural activity during periods of rest. To discern the origin of resting state CBV, we perturbed local neural activity and observed that spontaneous fluctuations in CBV and vessel diameter persisted when local neural spiking, glutamatergic input, and noradrenergic modulation were blocked. These results indicated that spontaneous hemodynamic signals observed in resting-state imaging data reflect a combination of behavior, local neural activity, and putatively non-neural processes. Advisors/Committee Members: Patrick James Drew, Dissertation Advisor.

Subjects/Keywords: Neurovascular Coupling; Behavior; Barrel Cortex; Spontaneous Hemodynamics

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APA (6^th Edition):

Winder, A. (2017). Origins of Spontaneous Hemodynamic Signals in the Awake Brain. (Thesis). Penn State University. Retrieved from https://etda.libraries.psu.edu/catalog/14417atw155

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Winder, Aaron. “Origins of Spontaneous Hemodynamic Signals in the Awake Brain.” 2017. Thesis, Penn State University. Accessed July 24, 2019. https://etda.libraries.psu.edu/catalog/14417atw155.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Winder, Aaron. “Origins of Spontaneous Hemodynamic Signals in the Awake Brain.” 2017. Web. 24 Jul 2019.

Vancouver:

Winder A. Origins of Spontaneous Hemodynamic Signals in the Awake Brain. [Internet] [Thesis]. Penn State University; 2017. [cited 2019 Jul 24]. Available from: https://etda.libraries.psu.edu/catalog/14417atw155.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Winder A. Origins of Spontaneous Hemodynamic Signals in the Awake Brain. [Thesis]. Penn State University; 2017. Available from: https://etda.libraries.psu.edu/catalog/14417atw155

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Hong Kong University of Science and Technology

28. Ou, Chubin MAE. Computational modeling of thrombosis in cerebral aneurysms.

Degree: 2016, Hong Kong University of Science and Technology

URL: https://doi.org/10.14711/thesis-b1585093 ; http://repository.ust.hk/ir/bitstream/1783.1-97121/1/th_redirect.html

► Thrombus plays an important role in the progression, rupture and healing of cerebral aneurysms. Nowadays, cerebral aneurysms are usually treated with endovascular techniques including coiling… (more)

Subjects/Keywords: Intracranial aneurysms; Thrombosis; Computer simulation; Hemodynamics

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APA (6^th Edition):

Ou, C. M. (2016). Computational modeling of thrombosis in cerebral aneurysms. (Thesis). Hong Kong University of Science and Technology. Retrieved from https://doi.org/10.14711/thesis-b1585093 ; http://repository.ust.hk/ir/bitstream/1783.1-97121/1/th_redirect.html

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Ou, Chubin MAE. “Computational modeling of thrombosis in cerebral aneurysms.” 2016. Thesis, Hong Kong University of Science and Technology. Accessed July 24, 2019. https://doi.org/10.14711/thesis-b1585093 ; http://repository.ust.hk/ir/bitstream/1783.1-97121/1/th_redirect.html.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Ou, Chubin MAE. “Computational modeling of thrombosis in cerebral aneurysms.” 2016. Web. 24 Jul 2019.

Vancouver:

Ou CM. Computational modeling of thrombosis in cerebral aneurysms. [Internet] [Thesis]. Hong Kong University of Science and Technology; 2016. [cited 2019 Jul 24]. Available from: https://doi.org/10.14711/thesis-b1585093 ; http://repository.ust.hk/ir/bitstream/1783.1-97121/1/th_redirect.html.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Ou CM. Computational modeling of thrombosis in cerebral aneurysms. [Thesis]. Hong Kong University of Science and Technology; 2016. Available from: https://doi.org/10.14711/thesis-b1585093 ; http://repository.ust.hk/ir/bitstream/1783.1-97121/1/th_redirect.html

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Oklahoma

29. Down, Linden. COMPUTATIONAL INVESTIGATIONS OF RED BLOOD CELL MECHANICAL TRAUMA AND OF DISEASED RENAL ARTERY HEMODYNAMICS.

Degree: PhD, 2011, University of Oklahoma

URL: http://hdl.handle.net/11244/318772

► Simulations of diseased renal arteries were also performed, which included simulations of stenoses and aneurysms of varying geometries. Initially, this work was done solely with… (more)

Subjects/Keywords: Blood flow; Hemodynamics; Renal artery – Diseases

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APA (6^th Edition):

Down, L. (2011). COMPUTATIONAL INVESTIGATIONS OF RED BLOOD CELL MECHANICAL TRAUMA AND OF DISEASED RENAL ARTERY HEMODYNAMICS. (Doctoral Dissertation). University of Oklahoma. Retrieved from http://hdl.handle.net/11244/318772

Chicago Manual of Style (16^th Edition):

Down, Linden. “COMPUTATIONAL INVESTIGATIONS OF RED BLOOD CELL MECHANICAL TRAUMA AND OF DISEASED RENAL ARTERY HEMODYNAMICS.” 2011. Doctoral Dissertation, University of Oklahoma. Accessed July 24, 2019. http://hdl.handle.net/11244/318772.

MLA Handbook (7^th Edition):

Down, Linden. “COMPUTATIONAL INVESTIGATIONS OF RED BLOOD CELL MECHANICAL TRAUMA AND OF DISEASED RENAL ARTERY HEMODYNAMICS.” 2011. Web. 24 Jul 2019.

Vancouver:

Down L. COMPUTATIONAL INVESTIGATIONS OF RED BLOOD CELL MECHANICAL TRAUMA AND OF DISEASED RENAL ARTERY HEMODYNAMICS. [Internet] [Doctoral dissertation]. University of Oklahoma; 2011. [cited 2019 Jul 24]. Available from: http://hdl.handle.net/11244/318772.

Council of Science Editors:

Down L. COMPUTATIONAL INVESTIGATIONS OF RED BLOOD CELL MECHANICAL TRAUMA AND OF DISEASED RENAL ARTERY HEMODYNAMICS. [Doctoral Dissertation]. University of Oklahoma; 2011. Available from: http://hdl.handle.net/11244/318772

University of Waterloo

30. Fawcett, Allie. The Influence of Timing on the Hemodynamic Effects of Compression Devices and Development of Sensor Driven Timing Mechanisms.

Degree: 2018, University of Waterloo

URL: http://hdl.handle.net/10012/14024

► Long periods of reduced mobility are associated with formation of blood clots in the deep veins of the legs, referred to as deep vein thrombosis… (more)

▼ Long periods of reduced mobility are associated with formation of blood clots in the deep veins of the legs, referred to as deep vein thrombosis (DVT). DVT has been noted as a large factor of morbidity and mortality in clinical settings as the clots can move from the legs to the lungs causing blockages, known as pulmonary embolisms. Preventing venous stasis has been clinically linked to preventing DVT formation. Venous stasis can be prevented by applying active mechanical compressions to the lower limbs, such as with an intermittent pneumatic compression (IPC) device; these devices have been clinically shown to reduce venous stasis and thereby prevent DVT formation. The main objectives of this thesis were to assess and improve a custom cardiac gated compression (CGC) system that times compressions based on an individual’s heartrate so as to only apply compressions during the diastolic phase of the cardiac cycle. A comparative performance assessment was done by measuring the central and peripheral hemodynamic changes induced by the use of different IPC devices (ArjoHuntleigh Flowtron ACS800 (Flowtron), Kendall SCD Express (SCD), Aircast Venaflow Elite (VenaFlow), and the custom CGC system) on 12 healthy human subjects in both seated and supine positions. The four selected compression devices had similar applied pressure levels, but dramatically different application profiles with regards to timing and method of application (e.g., single uniform bladder versus sequential inflation from ankle to knee). In addition, the compression systems were delineated by “smart” versus fixed timing, with two devices employing physiological measures to adjust when compression occurred (SCD: slow inflation based on vascular refill time; CGC: rapid inflation based on cardiac gating), and two inflating at fixed intervals (VenaFlow: rapid inflation; Flowtron: slow inflation). The devices were tested for ten minutes while heart rate, stroke volume, cardiac output, calf muscle oxygenation, and femoral venous and superficial femoral arterial velocities measures were collected. From the femoral venous velocities, the velocity per minute, peak velocity during the compression period, and the displacement per compression and per hour were used as performance metrics. With respect to the peak velocity the VenaFlow resulted in higher results than all other devices; likely due to its rapid inflation characteristics and the frequency of compressions allowing pooling to occur in the legs. However, in the performance metric of average displacement per compression the Flowtron and SCD resulted in the greatest displacements; likely because of the devices’ longer inflation periods resulting in a longer increase in venous velocity per compression. However, this measure does not account for the frequency of compressions unlike the displacement per hour measurement; the displacement of venous blood per hour resulted in the CGC device performing as well as the slow inflation devices during supine and resulted in greater displacement than all other…

Subjects/Keywords: Engineering; Biomedical; Sensors; Medical Device; Sensor Development; Electronics; Central Hemodynamics; Peripheral Hemodynamics

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APA (6^th Edition):

Fawcett, A. (2018). The Influence of Timing on the Hemodynamic Effects of Compression Devices and Development of Sensor Driven Timing Mechanisms. (Thesis). University of Waterloo. Retrieved from http://hdl.handle.net/10012/14024

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Fawcett, Allie. “The Influence of Timing on the Hemodynamic Effects of Compression Devices and Development of Sensor Driven Timing Mechanisms.” 2018. Thesis, University of Waterloo. Accessed July 24, 2019. http://hdl.handle.net/10012/14024.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Fawcett, Allie. “The Influence of Timing on the Hemodynamic Effects of Compression Devices and Development of Sensor Driven Timing Mechanisms.” 2018. Web. 24 Jul 2019.

Vancouver:

Fawcett A. The Influence of Timing on the Hemodynamic Effects of Compression Devices and Development of Sensor Driven Timing Mechanisms. [Internet] [Thesis]. University of Waterloo; 2018. [cited 2019 Jul 24]. Available from: http://hdl.handle.net/10012/14024.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Fawcett A. The Influence of Timing on the Hemodynamic Effects of Compression Devices and Development of Sensor Driven Timing Mechanisms. [Thesis]. University of Waterloo; 2018. Available from: http://hdl.handle.net/10012/14024

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Open Access Theses and Dissertations