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You searched for subject:(Hemodynamics AND Hemorheology). Showing records 1 – 2 of 2 total matches.

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McGill University

1. Drapeau, Guy. Comparative numerical study of the intra-vessel flow characteristics between a flat and a cylindrical configuration in a stented wall region.

Degree: M. Eng., Department of Biomedical Engineering Dept., 2007, McGill University

Mechanical stresses and flow dynamics alteration in a stented artery region are known to stimulate intimal thickening and increase the risk of restenosis, the closure of a revascularized artery. Particle imaging velocimetry (PIV) is an optical flow visualization technique that can be used to characterize the local flow dynamics around different stent structures. However, the usual cylindrical stent geometries present visualization difficulties when using an optical measurement technique such as the PIV technique. Using a flat configuration of a stent model presents advantages over the usual cylindrical model. A planar stent model makes data acquisition easier in planes cutting through the model due to its flat geometry that is compatible with the PIV planar flow investigation technique. Furthermore, with the planar stent configuration model velocity measurements and their associated flow features can be done without inducing refraction of the laser light sheet occurring with the cylindrical model's curvature. The refraction of light should be avoided since measurement errors and reflections are the resulting effects of this laser light plane deviation when passing through the curvature of a cylindrical stent model.

The spatial and temporal distribution of the Wall Shear Stress (WSS), which is believed to be of primary importance in the development of restenosis should be comparable between the flat and the cylindrical stent configuration models. The velocity and shear strain rate distributions will be compared between the flat and cylindrical stent configurations using computational fluid dynamics (CFD) simulations in order to analyse the feasibility of using a flat instead of a cylindrical version of the stent model for PIV experiments. It will be shown that for a physiological pulsatile flow the flat model yields results in shear strain rate spatial and temporal distribution that is comparable to the cylindrical model. A more PIV compatible, efficient and less refractive error prone validated flat model would be advantageous when several stent designs influence on the local hemodynamics around the strut geometries have to be studied quantitatively and optimized.

Subjects/Keywords: Stents.; Prosthesis Design.; Hemodynamics; Hemorheology.; Coronary Restenosis  – prevention & control.; Computer Simulation.

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Drapeau, G. (2007). Comparative numerical study of the intra-vessel flow characteristics between a flat and a cylindrical configuration in a stented wall region. (Masters Thesis). McGill University. Retrieved from http://digitool.library.mcgill.ca/thesisfile112566.pdf

Chicago Manual of Style (16th Edition):

Drapeau, Guy. “Comparative numerical study of the intra-vessel flow characteristics between a flat and a cylindrical configuration in a stented wall region.” 2007. Masters Thesis, McGill University. Accessed September 16, 2019. http://digitool.library.mcgill.ca/thesisfile112566.pdf.

MLA Handbook (7th Edition):

Drapeau, Guy. “Comparative numerical study of the intra-vessel flow characteristics between a flat and a cylindrical configuration in a stented wall region.” 2007. Web. 16 Sep 2019.

Vancouver:

Drapeau G. Comparative numerical study of the intra-vessel flow characteristics between a flat and a cylindrical configuration in a stented wall region. [Internet] [Masters thesis]. McGill University; 2007. [cited 2019 Sep 16]. Available from: http://digitool.library.mcgill.ca/thesisfile112566.pdf.

Council of Science Editors:

Drapeau G. Comparative numerical study of the intra-vessel flow characteristics between a flat and a cylindrical configuration in a stented wall region. [Masters Thesis]. McGill University; 2007. Available from: http://digitool.library.mcgill.ca/thesisfile112566.pdf

2. Charoenphol, Phapanin. Role of Carrier Size, Hemodynamics and Hemorheology in the Efficacy of Vascular-Targeted Spherical Drug Carriers.

Degree: PhD, Chemical Engineering, 2012, University of Michigan

Spherical polymeric particles in the submicron down to tens nanometers size range are extensively proposed for use as vascular-targeted drug carriers (VTDCs); however, very limited studies have explored their capacity to efficiently localize and adhere to the vascular wall. The studies presented in this dissertation are focused on characterizing the role of particle size, blood flow dynamics (hemodynamics) and blood cells (hemorheology) on dictating the targeting (localization and binding) efficiency of VTDCs at the vascular wall in physiological human bulk blood flow via in vitro parallel plate flow assays. The presented results show that the binding efficiency of VTDCs is a function of particle size in all flow types (i.e. laminar, pulsatile and recirculating flow) and is strongly modulated by the presence of red blood cells (RBCs). Specifically, the migration of RBCs away from the wall under shear flow creating the RBC-free layer (CFL) at the wall vicinity where leukocytes and microspheres are disproportionally concentrated whereas nanospheres tend to get trapped within the RBC core. The binding of localized particle is either enhanced or hindered depending on the ratio of particle size to the CFL width that can vary with the volume fraction of RBCs (% Hct), blood vessel size and wall shear rate. White blood cells (WBCs) tend to hinder microsphere binding due to their collision with bound particles associated with their tethering on the vascular wall, which increases the drag force on particles leading to particle removal. Overall, the presented results suggest that intermediate-size microspheres, 2–5 micrometers, not nanospheres or large microspheres, are the optimal particle sizes for targeting the wall from human blood flow in medium to large-sized blood vessels relevant in several cardiovascular diseases. The relevance of the presented in vitro results were valid with ex vivo model of mouse blood where it is found that the subtle differences in RBC sizes and hemorheology among various animal models utilized in drug delivery research can differently manipulate the particle dynamics and their eventual adhesion in blood flow; thus, raising the awareness of possible result deviation from animal models to human. Advisors/Committee Members: Eniola-Adefeso, Lola (committee member), Bull, Joseph L. (committee member), Burns, Mark A. (committee member), Gulari, Erdogan (committee member).

Subjects/Keywords: Vascular-targeted Delivery; Nano- and Micro-particles; Hemodynamics and Hemorheology; Inflammation; In Vitro Flow Assays; Margination; Chemical Engineering; Engineering

Hemodynamics and Hemorheology in the Efficacy of Vascular-Targeted Spherical Drug Carriers by… …hemodynamics) and blood cells (hemorheology) on dictating the targeting (… …where it is found that the subtle differences in RBC sizes and hemorheology among various… …need to be considered including targeting, hemodynamics and carrier physical properties… …Hemodynamics Property Prior to their interaction with the target sites, the drug carriers must be… 

Record DetailsSimilar RecordsGoogle PlusoneFacebookTwitterCiteULikeMendeleyreddit

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Charoenphol, P. (2012). Role of Carrier Size, Hemodynamics and Hemorheology in the Efficacy of Vascular-Targeted Spherical Drug Carriers. (Doctoral Dissertation). University of Michigan. Retrieved from http://hdl.handle.net/2027.42/91589

Chicago Manual of Style (16th Edition):

Charoenphol, Phapanin. “Role of Carrier Size, Hemodynamics and Hemorheology in the Efficacy of Vascular-Targeted Spherical Drug Carriers.” 2012. Doctoral Dissertation, University of Michigan. Accessed September 16, 2019. http://hdl.handle.net/2027.42/91589.

MLA Handbook (7th Edition):

Charoenphol, Phapanin. “Role of Carrier Size, Hemodynamics and Hemorheology in the Efficacy of Vascular-Targeted Spherical Drug Carriers.” 2012. Web. 16 Sep 2019.

Vancouver:

Charoenphol P. Role of Carrier Size, Hemodynamics and Hemorheology in the Efficacy of Vascular-Targeted Spherical Drug Carriers. [Internet] [Doctoral dissertation]. University of Michigan; 2012. [cited 2019 Sep 16]. Available from: http://hdl.handle.net/2027.42/91589.

Council of Science Editors:

Charoenphol P. Role of Carrier Size, Hemodynamics and Hemorheology in the Efficacy of Vascular-Targeted Spherical Drug Carriers. [Doctoral Dissertation]. University of Michigan; 2012. Available from: http://hdl.handle.net/2027.42/91589

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