subject:(Heck reaction)

Universidade Estadual de Campinas

1. Silva, Allan Ribeiro da, 1989-. Reações de oxa-Heck-Matsuda enantiosseletivas envolvendo sistemas estirênicos : síntese enantiosseletiva de sistemas trans-diidrobenzofuranos substituídos e síntese total da neolignana natural (-)-conocarpano: Enantioselective oxy-Heck-Matsuda arylation in styrenic system : enantioselective synthesis of substituted trans-dihydrobenzofuram system and total synthesis of the neolignan (-)-conocarpan.

Degree: 2017, Universidade Estadual de Campinas

URL: http://repositorio.unicamp.br/jspui/handle/REPOSIP/330757

► Abstract: The formation of C-C bonds in an enantioselective manner is of crucial importance in organic synthesis. In this regard, the enantioselective Heck¿Matsuda reaction is… (more)

Subjects/Keywords: Heck-Matsuda, reação de; Sais de diazônio; Heck-Matsuda enantiosseletiva; Heck-Matsuda reaction; Diazonium salts; Enantioselective Heck-Matsuda

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Silva, Allan Ribeiro da, 1. (2017). Reações de oxa-Heck-Matsuda enantiosseletivas envolvendo sistemas estirênicos : síntese enantiosseletiva de sistemas trans-diidrobenzofuranos substituídos e síntese total da neolignana natural (-)-conocarpano: Enantioselective oxy-Heck-Matsuda arylation in styrenic system : enantioselective synthesis of substituted trans-dihydrobenzofuram system and total synthesis of the neolignan (-)-conocarpan. (Thesis). Universidade Estadual de Campinas. Retrieved from http://repositorio.unicamp.br/jspui/handle/REPOSIP/330757

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Silva, Allan Ribeiro da, 1989-. “Reações de oxa-Heck-Matsuda enantiosseletivas envolvendo sistemas estirênicos : síntese enantiosseletiva de sistemas trans-diidrobenzofuranos substituídos e síntese total da neolignana natural (-)-conocarpano: Enantioselective oxy-Heck-Matsuda arylation in styrenic system : enantioselective synthesis of substituted trans-dihydrobenzofuram system and total synthesis of the neolignan (-)-conocarpan.” 2017. Thesis, Universidade Estadual de Campinas. Accessed March 06, 2021. http://repositorio.unicamp.br/jspui/handle/REPOSIP/330757.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Silva, Allan Ribeiro da, 1989-. “Reações de oxa-Heck-Matsuda enantiosseletivas envolvendo sistemas estirênicos : síntese enantiosseletiva de sistemas trans-diidrobenzofuranos substituídos e síntese total da neolignana natural (-)-conocarpano: Enantioselective oxy-Heck-Matsuda arylation in styrenic system : enantioselective synthesis of substituted trans-dihydrobenzofuram system and total synthesis of the neolignan (-)-conocarpan.” 2017. Web. 06 Mar 2021.

Vancouver:

Silva, Allan Ribeiro da 1. Reações de oxa-Heck-Matsuda enantiosseletivas envolvendo sistemas estirênicos : síntese enantiosseletiva de sistemas trans-diidrobenzofuranos substituídos e síntese total da neolignana natural (-)-conocarpano: Enantioselective oxy-Heck-Matsuda arylation in styrenic system : enantioselective synthesis of substituted trans-dihydrobenzofuram system and total synthesis of the neolignan (-)-conocarpan. [Internet] [Thesis]. Universidade Estadual de Campinas; 2017. [cited 2021 Mar 06]. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/330757.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Silva, Allan Ribeiro da 1. Reações de oxa-Heck-Matsuda enantiosseletivas envolvendo sistemas estirênicos : síntese enantiosseletiva de sistemas trans-diidrobenzofuranos substituídos e síntese total da neolignana natural (-)-conocarpano: Enantioselective oxy-Heck-Matsuda arylation in styrenic system : enantioselective synthesis of substituted trans-dihydrobenzofuram system and total synthesis of the neolignan (-)-conocarpan. [Thesis]. Universidade Estadual de Campinas; 2017. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/330757

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Université de Bordeaux I

2. Nassar Hardy, Luma. Tandem reactions using multi-task catalysts : Réaction en tandem par catalyse hétérogène.

Degree: Docteur es, Chimie organique, 2011, Université de Bordeaux I

URL: http://www.theses.fr/2011BOR14317

►

Le développement d’une chimie propre et donc durable est un des challenges majeurs du 21ème siècle dans les pays industrialisés. Étant au cœur de nombreuses… (more)

▼

Le développement d’une chimie propre et donc durable est un des challenges majeurs du 21ème siècle dans les pays industrialisés. Étant au cœur de nombreuses découvertes dans divers domaines scientifiques allant de la physique à la médecine, les sciences chimiques doivent jouer un rôle central pour résoudre un certain nombre de problèmes environnementaux auxquels nous devons faire face. Mon travail de thèse s’inscrit dans cette problématique par le développement de méthodologies de synthèse faisant intervenir plusieurs transformations dans le même réacteur. Nous avons notamment développé des séquences réactionnelles appelées HRC (pour Heck-Reduction-Cyclization, en anglais) prenant appui sur le caractère multi-tâche d’un catalyseur à base de palladium. Ces travaux nous ont permis de préparer une grande variété d’hétérocyles ou composés fonctionnalisés parmi lesquels nous pouvons citer les oxindoles, les indanones, ou encore les naphthoxindoles. Ces travaux ont donné lieu pour le moment à quatre publications dans des journaux à comité de lecture.

The development of clean chemistry and therefore sustainable is one of the major challenges of the 21st century in industrialized countries. Being in the heart of many discoveries in various scientific fields ranging from physics to medicine, the chemical sciences must play a central role in solving a number of environmental problems we face. My thesis work is part of this problem through the development of synthetic methodologies involving several transformations in the same reactor. We have developed the reaction sequences called HRC (for Heck-Reduction-cyclization) building on the multi-task of a palladium catalyst. This work allowed us to prepare a variety of functionalized heterocycles or compounds from which we can cite the oxindole, the indanones, or the naphthoxindoles. This work has resulted for the time four publications in peer-reviewed journals.

Advisors/Committee Members: Fouquet, Éric (thesis director), Felpin, François-Xavier (thesis director).

Subjects/Keywords: Reaction de Heck-Matsuda; Reaction de Heck; Sel de diazonium; One-pot; HRC strategy; Heck reaction; Heck-Matsuda reaction; Diazonium salt; One- pot; HRC strategy

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Nassar Hardy, L. (2011). Tandem reactions using multi-task catalysts : Réaction en tandem par catalyse hétérogène. (Doctoral Dissertation). Université de Bordeaux I. Retrieved from http://www.theses.fr/2011BOR14317

Chicago Manual of Style (16^th Edition):

Nassar Hardy, Luma. “Tandem reactions using multi-task catalysts : Réaction en tandem par catalyse hétérogène.” 2011. Doctoral Dissertation, Université de Bordeaux I. Accessed March 06, 2021. http://www.theses.fr/2011BOR14317.

MLA Handbook (7^th Edition):

Nassar Hardy, Luma. “Tandem reactions using multi-task catalysts : Réaction en tandem par catalyse hétérogène.” 2011. Web. 06 Mar 2021.

Vancouver:

Nassar Hardy L. Tandem reactions using multi-task catalysts : Réaction en tandem par catalyse hétérogène. [Internet] [Doctoral dissertation]. Université de Bordeaux I; 2011. [cited 2021 Mar 06]. Available from: http://www.theses.fr/2011BOR14317.

Council of Science Editors:

Nassar Hardy L. Tandem reactions using multi-task catalysts : Réaction en tandem par catalyse hétérogène. [Doctoral Dissertation]. Université de Bordeaux I; 2011. Available from: http://www.theses.fr/2011BOR14317

University of Delaware

3. McAtee, Jesse Ryan. Development of the first and second-generation Silyl-Heck reactions.

Degree: PhD, University of Delaware, Department of Chemistry and Biochemistry, 2015, University of Delaware

URL: http://udspace.udel.edu/handle/19716/17487

► Allyl and vinylsilanes are important nucleophiles in organic synthesis. They are stable reagents that can participate in a variety of transformations including mainly Hosomi-Sakurai crotylations,… (more)

Subjects/Keywords: Heck reaction.; Silane compounds.; Ligands.; Catalysis.

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APA (6^th Edition):

McAtee, J. R. (2015). Development of the first and second-generation Silyl-Heck reactions. (Doctoral Dissertation). University of Delaware. Retrieved from http://udspace.udel.edu/handle/19716/17487

Chicago Manual of Style (16^th Edition):

McAtee, Jesse Ryan. “Development of the first and second-generation Silyl-Heck reactions.” 2015. Doctoral Dissertation, University of Delaware. Accessed March 06, 2021. http://udspace.udel.edu/handle/19716/17487.

MLA Handbook (7^th Edition):

McAtee, Jesse Ryan. “Development of the first and second-generation Silyl-Heck reactions.” 2015. Web. 06 Mar 2021.

Vancouver:

McAtee JR. Development of the first and second-generation Silyl-Heck reactions. [Internet] [Doctoral dissertation]. University of Delaware; 2015. [cited 2021 Mar 06]. Available from: http://udspace.udel.edu/handle/19716/17487.

Council of Science Editors:

McAtee JR. Development of the first and second-generation Silyl-Heck reactions. [Doctoral Dissertation]. University of Delaware; 2015. Available from: http://udspace.udel.edu/handle/19716/17487

University of Illinois – Chicago

4. Parasram, Marvin. Development of Heck and Desaturation Reactions Involving Novel Hybrid Palladium-Radical Intermediates.

Degree: 2017, University of Illinois – Chicago

URL: http://hdl.handle.net/10027/22205

► The first part of the thesis focuses on the development of the first endo-selective Pd-catalyzed Heck reaction of iodomethylsilyl ethers of phenols and alkenols leading… (more)

Subjects/Keywords: Heck reaction; Desaturation; C–H Functionalization

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APA (6^th Edition):

Parasram, M. (2017). Development of Heck and Desaturation Reactions Involving Novel Hybrid Palladium-Radical Intermediates. (Thesis). University of Illinois – Chicago. Retrieved from http://hdl.handle.net/10027/22205

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Parasram, Marvin. “Development of Heck and Desaturation Reactions Involving Novel Hybrid Palladium-Radical Intermediates.” 2017. Thesis, University of Illinois – Chicago. Accessed March 06, 2021. http://hdl.handle.net/10027/22205.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Parasram, Marvin. “Development of Heck and Desaturation Reactions Involving Novel Hybrid Palladium-Radical Intermediates.” 2017. Web. 06 Mar 2021.

Vancouver:

Parasram M. Development of Heck and Desaturation Reactions Involving Novel Hybrid Palladium-Radical Intermediates. [Internet] [Thesis]. University of Illinois – Chicago; 2017. [cited 2021 Mar 06]. Available from: http://hdl.handle.net/10027/22205.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Parasram M. Development of Heck and Desaturation Reactions Involving Novel Hybrid Palladium-Radical Intermediates. [Thesis]. University of Illinois – Chicago; 2017. Available from: http://hdl.handle.net/10027/22205

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universidade Estadual de Campinas

5. Prediger, Patrícia, 1984-. Reações de arilação de Heck com sais de arenodiazônio : estudos metodológicos e aplicações nas sínteses de compostos bioativos: Heck arylations with arenediazonium salts : methodological studies and application on bioactive compounds synthesis.

Degree: 2012, Universidade Estadual de Campinas

URL: http://repositorio.unicamp.br/jspui/handle/REPOSIP/249886

► Abstract: The present work was focused in the Heck-Matsuda arylation of several olefins with arenediazonium salts and in the application of the arylated products as… (more)

▼ Abstract: The present work was focused in the Heck-Matsuda arylation of several olefins with arenediazonium salts and in the application of the arylated products as intermediates in the syntheses of bioactive compounds. The work is divided in two chapters: 1) Heck-Matsuda reactions between allyl amines and arenediazonium salts and their applications in the synthesis of bioactive compounds, 2) Studies of the Heck-Matsuda reaction in ionic liquids and its application to the synthesis of Cazanucleosides, which are potential antituberculosis compounds. Regarding the first part of this work, a comprehensive methodology for the Heck-Matsuda reaction between allylamines and arenediazonium salts was developed. Several allyl amines derivatives and differents arenediazonium salts were sucessfully employed. Both electron donating and withdrawing groups, as well as bulky substituents, were well tolerated in the diazonium salt. In all cases good to excellent yields and high regio- and stereoselectivities in favor of the ¿×-trans arylated products were obtained. Additionally, some of the adducts prepared by this highly selective Heck reaction were employed as intermediates in the total synthesis of the bioactive compounds naftifine, abamine, abamine SG, alverine and cinacalcet hydrochloride. The second part of this work adressed the Heck-Matsuda reaction between allylic phthalimide and arenediazonium salts in ionic liquids. Under the investigated conditions, the yields and selectivities were similar to those previous achieved with the conventional solvent benzonitrile. In addition, we evaluated the in situ generation of the 4-fluorbenzenediazonium hexafluorophosphate salt in [bmim][PF6], followed by the Heck-Matsuda reaction in a one pot procedure. Finally, we carried out the synthesis of two C-azanucleosides using the Heck-Matsuda reaction with an endocyclic enecarbamate as the key step. As a further development of this work, these compounds will be evaluated regarding their potential antituberculosis activity by Professor Mourey's research group in Toulouse, France Advisors/Committee Members: UNIVERSIDADE ESTADUAL DE CAMPINAS (CRUESP), Correia, Carlos Roque Duarte, 1953- (advisor), Universidade Estadual de Campinas. Instituto de Química (institution), Programa de Pós-Graduação em Química (nameofprogram), Coelho, Fernando Antonio Santos (committee member), Baptistella, Lucia Helena Brito (committee member), Monteiro, Adriano Lisboa (committee member), Brocksom, Timothy John (committee member).

Subjects/Keywords: Reação de Heck; Alilaminas; Sais de arenodiazônio; Paládio; Heck reaction; Allylamines; Arenediazonium salts; Palladium

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APA (6^th Edition):

Prediger, Patrícia, 1. (2012). Reações de arilação de Heck com sais de arenodiazônio : estudos metodológicos e aplicações nas sínteses de compostos bioativos: Heck arylations with arenediazonium salts : methodological studies and application on bioactive compounds synthesis. (Thesis). Universidade Estadual de Campinas. Retrieved from http://repositorio.unicamp.br/jspui/handle/REPOSIP/249886

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Prediger, Patrícia, 1984-. “Reações de arilação de Heck com sais de arenodiazônio : estudos metodológicos e aplicações nas sínteses de compostos bioativos: Heck arylations with arenediazonium salts : methodological studies and application on bioactive compounds synthesis.” 2012. Thesis, Universidade Estadual de Campinas. Accessed March 06, 2021. http://repositorio.unicamp.br/jspui/handle/REPOSIP/249886.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Prediger, Patrícia, 1984-. “Reações de arilação de Heck com sais de arenodiazônio : estudos metodológicos e aplicações nas sínteses de compostos bioativos: Heck arylations with arenediazonium salts : methodological studies and application on bioactive compounds synthesis.” 2012. Web. 06 Mar 2021.

Vancouver:

Prediger, Patrícia 1. Reações de arilação de Heck com sais de arenodiazônio : estudos metodológicos e aplicações nas sínteses de compostos bioativos: Heck arylations with arenediazonium salts : methodological studies and application on bioactive compounds synthesis. [Internet] [Thesis]. Universidade Estadual de Campinas; 2012. [cited 2021 Mar 06]. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/249886.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Prediger, Patrícia 1. Reações de arilação de Heck com sais de arenodiazônio : estudos metodológicos e aplicações nas sínteses de compostos bioativos: Heck arylations with arenediazonium salts : methodological studies and application on bioactive compounds synthesis. [Thesis]. Universidade Estadual de Campinas; 2012. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/249886

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universiteit Utrecht

6. Huang, Y. Practical catalytic arylation of C–H bonds by iron/phenanthroline systems.

Degree: 2015, Universiteit Utrecht

URL: http://dspace.library.uu.nl:8080/handle/1874/324941

► In Chapter 1, an overview is given of the current status of the field of non-precious metal catalyzed/mediated direct arylation reactions. Reports on direct arylations… (more)

▼ In Chapter 1, an overview is given of the current status of the field of non-precious metal catalyzed/mediated direct arylation reactions. Reports on direct arylations catalyzed by Fe, Co, Ni and Cu are mainly demonstrated and discussed. Chapter 2 described a pre-made iron-based catalytic system that is able to catalyze the direct arylation reaction between aryl halides and unactivated arenes under aerobic conditions and using non-distilled benzene as solvent and reagent. Chapter 3 focuses on unraveling structural information of the FPsystem and acquiring an understanding of the evolution of iron species during the direct arylation reactions. By employing a combination of IR, UV-Vis and XAS (XANES and EXAFS) techniques, together with the information from elemental analysis and ICP-OES, a conclusion can be draw that the main component in different FPE systems is almost the same, while in FPM systems (generated in methanol) these are quite different. The constitution of the main component in FP2Eand FP1M was proposed to be [Fe(phen)Cl3(CH3CH2OH)]∙0.5CH3CH2OH ∙0.5phen and [Fe(phen)2Cl2][FeCl4], respectively. Further investigation of FP2Esystems was performed in Chapter 4. First, a kinetic study of the FP2Ecatalyzed direct aryaltion of 4-iodoanisole and benzene in air under reflux was carried out. The comparison of catalytic reactivity of FPE and FPM systems were carried out in this chapter, too. In Chapter 5 the application of FP2E in the Heck-type reaction between 4-iodoanisole and styrene in air was investigated. However, initial results showed that the combination of the applied base and alcohol additive is able to catalyze such transformations in air albeit with moderate yield (58%). Following the observation, the effects of base, alcohol additive, and solvent on the air tolerance of this kind of reaction were investigated in this chapter. The employment of KOtBu and DMF proved to be crucial to the success of the Heck-type reaction in air with non-distilled solvent. A possible mechanism was proposed, which involves radical intermediates formed from the reaction between KOtBu and DMF. Advisors/Committee Members: Klein Gebbink, Bert, Moret, Marc-Etienne.

Subjects/Keywords: iron; direct arylation; air tolerant; kinetic study; Heck reaction; radical

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Huang, Y. (2015). Practical catalytic arylation of C–H bonds by iron/phenanthroline systems. (Doctoral Dissertation). Universiteit Utrecht. Retrieved from http://dspace.library.uu.nl:8080/handle/1874/324941

Chicago Manual of Style (16^th Edition):

Huang, Y. “Practical catalytic arylation of C–H bonds by iron/phenanthroline systems.” 2015. Doctoral Dissertation, Universiteit Utrecht. Accessed March 06, 2021. http://dspace.library.uu.nl:8080/handle/1874/324941.

MLA Handbook (7^th Edition):

Huang, Y. “Practical catalytic arylation of C–H bonds by iron/phenanthroline systems.” 2015. Web. 06 Mar 2021.

Vancouver:

Huang Y. Practical catalytic arylation of C–H bonds by iron/phenanthroline systems. [Internet] [Doctoral dissertation]. Universiteit Utrecht; 2015. [cited 2021 Mar 06]. Available from: http://dspace.library.uu.nl:8080/handle/1874/324941.

Council of Science Editors:

Huang Y. Practical catalytic arylation of C–H bonds by iron/phenanthroline systems. [Doctoral Dissertation]. Universiteit Utrecht; 2015. Available from: http://dspace.library.uu.nl:8080/handle/1874/324941

University of Johannesburg

7. Tshivhase, Mmboneni Gifty. Functionalised porphyrazines and their use in catalysis.

Degree: 2012, University of Johannesburg

URL: http://hdl.handle.net/10210/6024

►

D.Phil.

Porphyrazines like porphyrins and phthalocyanines have unique physical, chemical and spectral properties. This allows them to have many impressive applications. They are less studied… (more)

▼

D.Phil.

Porphyrazines like porphyrins and phthalocyanines have unique physical, chemical and spectral properties. This allows them to have many impressive applications. They are less studied than phthalocyanines because of the absence of convenient methods for their synthesis. However, recent studies, including this one, have made these compounds more accessible. The palladium-imidazolium salt systems have proved to be one of the most successful catalysts for the Heck and Suzuki coupling reactions. Substituents on nitrogen atoms of imidazolium significantly influence the catalytic activities of the corresponding palladiumimidazolium salt systems in the Heck and Suzuki coupling. The synthesis of the imidazolium salts is discussed in this study. The synthesis of the imidazoles started from diamines. A new route for the synthesis of 4,5-diaminophthalonitrile is discussed here and so far it is the most convenient and less tedious route with higher yields. The catalytic activities on different substrates have also been extensively investigated and gave impressive results, on the Heck and Suzuki reaction. The catalysis study was first performed using the dicyanoimidazolium salts and then with the imidazolium salts of the porphyrazines. The results indicate that both these systems are active ligands for Suzuki and Heck reactions. Two complexes, [1’,1’’-dibutyl-3’,3’’-(4,5-(1,2-dicyanobenzene))diimidazolium dibromide] and [2,3-benzo(2’,3’-(3’’,3’’’-dibutyldiimidazolium-2’,2’’-diylidene)palladium(II)- dibromide)-7,8,12,13,17,18-hexapropyl,porphyrazine] were synthesised successfully in good yields and used for Suzuki and Heck catalysis reactions. Catalyst recovery in homogeneous catalysis is always a major problem; this led this study to make use of porphyrazines in biphasic catalysis because of their high extinction coefficient which comes from their very intense colour. The reactions were performed in a combination of water with toluene and also water with ionic liquid. Both this systems gave results which proved that it is possible to separate the catalyst and the products once the reaction is complete. Two aminoporphyrazines and phthalonitriles were also synthesised in multistep synthesis. The synthesis involved a lot of protection and deprotection steps. These compounds are starting materials to aminophosphine ligands which have a wide variety of catalysis applications.

Subjects/Keywords: Catalysis; Porphyrins; Phthalocyanines; Palladium compounds; Heck reaction; Imidazoles; Ligands

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APA (6^th Edition):

Tshivhase, M. G. (2012). Functionalised porphyrazines and their use in catalysis. (Thesis). University of Johannesburg. Retrieved from http://hdl.handle.net/10210/6024

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Tshivhase, Mmboneni Gifty. “Functionalised porphyrazines and their use in catalysis.” 2012. Thesis, University of Johannesburg. Accessed March 06, 2021. http://hdl.handle.net/10210/6024.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Tshivhase, Mmboneni Gifty. “Functionalised porphyrazines and their use in catalysis.” 2012. Web. 06 Mar 2021.

Vancouver:

Tshivhase MG. Functionalised porphyrazines and their use in catalysis. [Internet] [Thesis]. University of Johannesburg; 2012. [cited 2021 Mar 06]. Available from: http://hdl.handle.net/10210/6024.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Tshivhase MG. Functionalised porphyrazines and their use in catalysis. [Thesis]. University of Johannesburg; 2012. Available from: http://hdl.handle.net/10210/6024

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Johannesburg

8. Yankey, Margaret. Imidazolyl- and pyrazolyl-salicylaldimine transition metal complexes and their applications in olefin transformation reactions.

Degree: 2011, University of Johannesburg

URL: http://hdl.handle.net/10210/3627

►

M.Sc.

This study deals with the synthesis of nitrogen-donor imidazolyl- and pyrazolyl-salicylaldimine compounds, their reactions with selected transition metals and applications as catalysts for Heck… (more)

Subjects/Keywords: Salicylates; Transition metal complexes; Alkenes; Catalysts; Heck reaction; Ligands

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APA (6^th Edition):

Yankey, M. (2011). Imidazolyl- and pyrazolyl-salicylaldimine transition metal complexes and their applications in olefin transformation reactions. (Thesis). University of Johannesburg. Retrieved from http://hdl.handle.net/10210/3627

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Yankey, Margaret. “Imidazolyl- and pyrazolyl-salicylaldimine transition metal complexes and their applications in olefin transformation reactions.” 2011. Thesis, University of Johannesburg. Accessed March 06, 2021. http://hdl.handle.net/10210/3627.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Yankey, Margaret. “Imidazolyl- and pyrazolyl-salicylaldimine transition metal complexes and their applications in olefin transformation reactions.” 2011. Web. 06 Mar 2021.

Vancouver:

Yankey M. Imidazolyl- and pyrazolyl-salicylaldimine transition metal complexes and their applications in olefin transformation reactions. [Internet] [Thesis]. University of Johannesburg; 2011. [cited 2021 Mar 06]. Available from: http://hdl.handle.net/10210/3627.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Yankey M. Imidazolyl- and pyrazolyl-salicylaldimine transition metal complexes and their applications in olefin transformation reactions. [Thesis]. University of Johannesburg; 2011. Available from: http://hdl.handle.net/10210/3627

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Toronto

9. Schulman, Jacqueline Madeleine. Synthesis of 1,2,3-Triazole-fused Heterocycles via Palladium Catalyzed Annulation of 5-Iodotriazoles.

Degree: 2011, University of Toronto

URL: http://hdl.handle.net/1807/31434

►

Increasing attention has recently been directed toward 1,2,3-triazole-containing compounds. With their unique properties and excellent stability, 1,4-disubstituted triazoles are readily accessible via the copper catalyzed… (more)

Subjects/Keywords: triazoles; palladium catalysis; Heck reaction; dirct arylation; organic chemistry; 0490

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APA (6^th Edition):

Schulman, J. M. (2011). Synthesis of 1,2,3-Triazole-fused Heterocycles via Palladium Catalyzed Annulation of 5-Iodotriazoles. (Masters Thesis). University of Toronto. Retrieved from http://hdl.handle.net/1807/31434

Chicago Manual of Style (16^th Edition):

Schulman, Jacqueline Madeleine. “Synthesis of 1,2,3-Triazole-fused Heterocycles via Palladium Catalyzed Annulation of 5-Iodotriazoles.” 2011. Masters Thesis, University of Toronto. Accessed March 06, 2021. http://hdl.handle.net/1807/31434.

MLA Handbook (7^th Edition):

Schulman, Jacqueline Madeleine. “Synthesis of 1,2,3-Triazole-fused Heterocycles via Palladium Catalyzed Annulation of 5-Iodotriazoles.” 2011. Web. 06 Mar 2021.

Vancouver:

Schulman JM. Synthesis of 1,2,3-Triazole-fused Heterocycles via Palladium Catalyzed Annulation of 5-Iodotriazoles. [Internet] [Masters thesis]. University of Toronto; 2011. [cited 2021 Mar 06]. Available from: http://hdl.handle.net/1807/31434.

Council of Science Editors:

Schulman JM. Synthesis of 1,2,3-Triazole-fused Heterocycles via Palladium Catalyzed Annulation of 5-Iodotriazoles. [Masters Thesis]. University of Toronto; 2011. Available from: http://hdl.handle.net/1807/31434

University of Newcastle

10. Al Otaibi, Ahmed Abdullah. Application of green chemistry approaches to cytotoxic compounds.

Degree: PhD, 2018, University of Newcastle

URL: http://hdl.handle.net/1959.13/1383620

►

Research Doctorate - Doctor of Philosophy (PhD)

The specific synthesis of organic compounds requires careful control of reaction parameters conditions, such as temperatures, pressure and… (more)

Subjects/Keywords: ionic liquids; cytotoxic compounds; heck reaction; flow chemistry

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APA (6^th Edition):

Al Otaibi, A. A. (2018). Application of green chemistry approaches to cytotoxic compounds. (Doctoral Dissertation). University of Newcastle. Retrieved from http://hdl.handle.net/1959.13/1383620

Chicago Manual of Style (16^th Edition):

Al Otaibi, Ahmed Abdullah. “Application of green chemistry approaches to cytotoxic compounds.” 2018. Doctoral Dissertation, University of Newcastle. Accessed March 06, 2021. http://hdl.handle.net/1959.13/1383620.

MLA Handbook (7^th Edition):

Al Otaibi, Ahmed Abdullah. “Application of green chemistry approaches to cytotoxic compounds.” 2018. Web. 06 Mar 2021.

Vancouver:

Al Otaibi AA. Application of green chemistry approaches to cytotoxic compounds. [Internet] [Doctoral dissertation]. University of Newcastle; 2018. [cited 2021 Mar 06]. Available from: http://hdl.handle.net/1959.13/1383620.

Council of Science Editors:

Al Otaibi AA. Application of green chemistry approaches to cytotoxic compounds. [Doctoral Dissertation]. University of Newcastle; 2018. Available from: http://hdl.handle.net/1959.13/1383620

University of Oxford

11. Baker, David Bawden. Applications of the Heck reaction for the syntheses of substituted pyridines and β,β-disubstituted vinyl Weinreb amides : studies towards the syntheses of inthomycin B and inthomycin C.

Degree: PhD, 2014, University of Oxford

URL: http://ora.ox.ac.uk/objects/uuid:09765f4e-83b9-4bb6-9130-7da3520752e6 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.627840

► The Heck reaction has become a fundamental reaction for synthetic organic chemists over the last half century and is utilised heavily in the fine chemical… (more)

Subjects/Keywords: 547; Organic chemistry; Organic synthesis; Synthetic organic chemistry; Heck reaction; Pyridines

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APA (6^th Edition):

Baker, D. B. (2014). Applications of the Heck reaction for the syntheses of substituted pyridines and β,β-disubstituted vinyl Weinreb amides : studies towards the syntheses of inthomycin B and inthomycin C. (Doctoral Dissertation). University of Oxford. Retrieved from http://ora.ox.ac.uk/objects/uuid:09765f4e-83b9-4bb6-9130-7da3520752e6 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.627840

Chicago Manual of Style (16^th Edition):

Baker, David Bawden. “Applications of the Heck reaction for the syntheses of substituted pyridines and β,β-disubstituted vinyl Weinreb amides : studies towards the syntheses of inthomycin B and inthomycin C.” 2014. Doctoral Dissertation, University of Oxford. Accessed March 06, 2021. http://ora.ox.ac.uk/objects/uuid:09765f4e-83b9-4bb6-9130-7da3520752e6 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.627840.

MLA Handbook (7^th Edition):

Baker, David Bawden. “Applications of the Heck reaction for the syntheses of substituted pyridines and β,β-disubstituted vinyl Weinreb amides : studies towards the syntheses of inthomycin B and inthomycin C.” 2014. Web. 06 Mar 2021.

Vancouver:

Baker DB. Applications of the Heck reaction for the syntheses of substituted pyridines and β,β-disubstituted vinyl Weinreb amides : studies towards the syntheses of inthomycin B and inthomycin C. [Internet] [Doctoral dissertation]. University of Oxford; 2014. [cited 2021 Mar 06]. Available from: http://ora.ox.ac.uk/objects/uuid:09765f4e-83b9-4bb6-9130-7da3520752e6 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.627840.

Council of Science Editors:

Baker DB. Applications of the Heck reaction for the syntheses of substituted pyridines and β,β-disubstituted vinyl Weinreb amides : studies towards the syntheses of inthomycin B and inthomycin C. [Doctoral Dissertation]. University of Oxford; 2014. Available from: http://ora.ox.ac.uk/objects/uuid:09765f4e-83b9-4bb6-9130-7da3520752e6 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.627840

Iowa State University

12. Kadam, Abhishek Ashok. Catalytic methods for alkene functionalization reactions.

Degree: 2019, Iowa State University

URL: https://lib.dr.iastate.edu/etd/17712

► This thesis presents the efforts towards developing transition metal-catalyzed protocols for rapid functionalization of alkenes. These protocols include - 1) enantioselective, palladium-catalyzed conjugate additions of… (more)

▼ This thesis presents the efforts towards developing transition metal-catalyzed protocols for rapid functionalization of alkenes. These protocols include - 1) enantioselective, palladium-catalyzed conjugate additions of arylboronic acids to generate compounds containing bis-benzylic quaternary stereocenter; 2) nickel-catalyzed three-component alkene carboacylation via activation of amide C-N bonds; 3) palladium-catalyzed intermolecular, acylative Heck reaction using amides as acyl electrophiles. Chapter II discusses a strategy to access cyclic ketones containing bis-benzylic quaternary stereocenters through enantioselective palladium-catalyzed conjugate additions of arylboronic acids to β-aryl β,β-disubstituted cyclic enones. The catalyst generated from palladium trifluoroacetate and a chiral, non-racemic (S)-4-tert-butyl-2-(2-pyridyl)oxazoline ligand allows conjugate addition of a wide range arylboronic acids to a variety of to β-aryl β,β-disubstituted cyclic enones to generate ketones containing bis-benzylic quaternary stereocenters in up to 92% yield and up to 93% ee. This protocol uses iterative addition strategy to minimize unproductive protodeboronation of arylboronic acid and leads to the formation of compounds containing bis-benzylic quaternary stereocenters. Chapter III describes the nickel-catalyzed intermolecular alkene carboacylation via activation of amide C-N bonds. The developed method allows rapid functionalization of bicyclic alkenes with a variety of N-benzoyl, N-phenylbenzamides, and triarylboranes to synthesize ketone products in up to 91% yield. Preliminary mechanistic analysis of the method reveals that migratory insertion precedes transmetalation and that reductive elimination is likely the rate-limiting step. Chapter IV discusses palladium-catalyzed intermolecular acylative Heck reaction using amides as acyl electrophiles. The catalyst generated from [Pd(allyl)Cl]2 and DPEphos promotes reaction between a wide range of N-aroylglutarimides and bicyclic alkenes to form alpha,beta-unsaturated ketones in moderate to high yields (25-82%). This work represents the first examples of transition metal-catalyzed intermolecular acylative Heck reaction using amides as acyl electrophiles.

Subjects/Keywords: carboacylation; conjugate addition; heck reaction; nickel; palladium; triphenylborane; Organic Chemistry

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APA (6^th Edition):

Kadam, A. A. (2019). Catalytic methods for alkene functionalization reactions. (Thesis). Iowa State University. Retrieved from https://lib.dr.iastate.edu/etd/17712

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Kadam, Abhishek Ashok. “Catalytic methods for alkene functionalization reactions.” 2019. Thesis, Iowa State University. Accessed March 06, 2021. https://lib.dr.iastate.edu/etd/17712.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Kadam, Abhishek Ashok. “Catalytic methods for alkene functionalization reactions.” 2019. Web. 06 Mar 2021.

Vancouver:

Kadam AA. Catalytic methods for alkene functionalization reactions. [Internet] [Thesis]. Iowa State University; 2019. [cited 2021 Mar 06]. Available from: https://lib.dr.iastate.edu/etd/17712.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Kadam AA. Catalytic methods for alkene functionalization reactions. [Thesis]. Iowa State University; 2019. Available from: https://lib.dr.iastate.edu/etd/17712

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Illinois – Urbana-Champaign

13. Delcamp, Jared H. Oxidative Heck Reactions with Terminal Olefins.

Degree: PhD, 0335, 2011, University of Illinois – Urbana-Champaign

URL: http://hdl.handle.net/2142/18626

► Sequential transformations in a single reaction have the potential to dramatically increase efficiency with respect to resources, time, and number of steps to access key… (more)

▼ Sequential transformations in a single reaction have the potential to dramatically increase efficiency with respect to resources, time, and number of steps to access key intermediates. When sequential C-H bonds are activated a bifunctional handle arises from seemingly inert functionality. This work describes a one-pot sequential allylic C-H esterification, vinylic C-H arylation. A previously reported Pd(II)/sulfoxide system is used to generate branched allylic esters from ??-olefins with only the addition of an aryl boronic acid to the reaction mixture. Styrenyl allylic esters are generated in good overall yield and excellent selectivities. The wide functional group tolerance and mild conditions of this three-component coupling reaction provide an attractive manifold for the rapid build-up of dense functionality around terminal olefins with minimal protecting group strategies or undesirable oxidation/reduction reactions.The synthetic utility of this reaction has been demonstrated through the synthesis of several intermediates to biologically active molecules. The ready availability and inertness of ??-olefins relative to the oxidized precursors required for other C???C bond forming methods means that fewer steps are required for their installation and maintenance throughout a synthetic sequence. Previously, allylic esters served as non-resonance directing groups on terminal olefin for the vinylic C???H arylation (Heck reaction). This manifold is unique because previous intermolecular Heck reaction conditions require an excess of resonance activated olefin coupling partner. Further exploration of directing groups to determine the underlying directing factors led to the discovery of several terminal olefin classes with diversedirecting elements. A general and highly selective intermolecular Heck arylation of non-resonance stabilized ??-olefins with aryl and stryenyl boronic reagents has been developed. The Pd(II)/sulfoxide catalyzed Heck reaction is performed under oxidative, acidic conditions and proceeds with good yields and excellent regio- and stereoselectivities to generate linear E-arylated olefins. Polyenes are prevalent motiefs in natural products and pharmaceuticals. Polyene functionality often requires mild and selective synthetic methods. The Heck vinylation uses orthogonally reactive C-H bonds and these bonds are often easy to carry through synthetic sequences. Despite this advantage, the synthetic potential of the intermolecular Heck reaction has not been realized in complex molecule formation. A method has been developed which overcomes the previous intermolecular Heck-vinylation shortcomings of excess terminal olefin and required resonance activation for regio- and stereoselectivities. The Pd(II)/sulfoxide catalyzed oxidative Heck vinylation proceeds under mild conditions to give polyene products with a variety of substitution patterns amid diverse functionality. The polyenes are formed in synthetically relevant yields with excellent stereoselectivities. Overall, the… Advisors/Committee Members: White, Maria C. (advisor), White, Maria C. (Committee Chair), Denmark, Scott E. (committee member), Hergenrother, Paul J. (committee member), Rogers, John A. (committee member).

Subjects/Keywords: Heck reaction; oxidative; Palladium; arylation; vinylation; transition metal catalysis

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Delcamp, J. H. (2011). Oxidative Heck Reactions with Terminal Olefins. (Doctoral Dissertation). University of Illinois – Urbana-Champaign. Retrieved from http://hdl.handle.net/2142/18626

Chicago Manual of Style (16^th Edition):

Delcamp, Jared H. “Oxidative Heck Reactions with Terminal Olefins.” 2011. Doctoral Dissertation, University of Illinois – Urbana-Champaign. Accessed March 06, 2021. http://hdl.handle.net/2142/18626.

MLA Handbook (7^th Edition):

Delcamp, Jared H. “Oxidative Heck Reactions with Terminal Olefins.” 2011. Web. 06 Mar 2021.

Vancouver:

Delcamp JH. Oxidative Heck Reactions with Terminal Olefins. [Internet] [Doctoral dissertation]. University of Illinois – Urbana-Champaign; 2011. [cited 2021 Mar 06]. Available from: http://hdl.handle.net/2142/18626.

Council of Science Editors:

Delcamp JH. Oxidative Heck Reactions with Terminal Olefins. [Doctoral Dissertation]. University of Illinois – Urbana-Champaign; 2011. Available from: http://hdl.handle.net/2142/18626

University of Iowa

14. Joshi, Madhur Satish. Elaboration of azine and azole anhydrobases via intra- and intermolecular cyclizations for heterocycle construction.

Degree: PhD, Chemistry, 2017, University of Iowa

URL: https://ir.uiowa.edu/etd/5788

► Aza-heterocycles such as pyridines, imidazoles, piperidines, etc. are ubiquitous structural motifs found in various natural products and pharmacologically active compounds. Thus, they are of… (more)

▼ Aza-heterocycles such as pyridines, imidazoles, piperidines, etc. are ubiquitous structural motifs found in various natural products and pharmacologically active compounds. Thus, they are of unparalleled importance to synthetic, medicinal, and materials chemists. Despite their structural significance, organic transformations available for the functionalization of these heterocycles remain underdeveloped. The development of several synthetic methods to construct aza-heterocyclic building blocks is described in this thesis, which, in turn, should facilitate the assembly of more elaborate frameworks present in bioactive molecules. An intramolecular palladium catalyzed Mizoroki-Heck cyclization of 4-alkylidene dihydropyridines with tethered aryl iodide electrophiles is demonstrated. This provides access to substituted isoindolinones and oxindoles in high yields. An asymmetric variant of this reaction using chiral phosphine ligands delivers enantioenriched oxindoles and isoindolinones. Additionally, an intramolecular Mizoroki-Heck reaction for the synthesis of 2-substituted pyridine derivatives is also developed. An array of fused isoindolinones is constructed as a mixture of diastereomers and further manipulated using chemical transformations to yield the corresponding pyridine and piperdine derivatives. Moreover, a formal [3+2] cyclocondensation of alkylidene dihydropyridines and aryl diazonium salts has been discovered for the synthesis of triazole derivatives. Tertiary amides deliver substituted 1,2,4-triazolium salts, whereas, secondary amides provide substituted, neutral 1,2,4-triazoles in excellent yields, under mild reaction conditions. Furthermore, an intramolecular direct arylation of 2- and 4-substituted alkylpyridines is developed for the synthesis of 2,3- and 3,4-cyclized pyridines. It is shown that 4-alkylpyridines tethered to aryl halides participate in a palladium catalyzed direct arylation to give fused 7-membered lactams in excellent yields. Lastly, an intramolecular cyclization of 1,2-alkylimidazoles is reported. Alkylidene imidazolines tethered to electrophilic keto-amide sidechains participate in an aldol-like reaction to yield γ-lactam products in good yields as mixtures of diastereomers. Advisors/Committee Members: Pigge, F. Christopher (supervisor).

Subjects/Keywords: Anhydrobases; Aza-heterocycles; Heck reaction; Pyridines; Triazoles; Chemistry

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APA (6^th Edition):

Joshi, M. S. (2017). Elaboration of azine and azole anhydrobases via intra- and intermolecular cyclizations for heterocycle construction. (Doctoral Dissertation). University of Iowa. Retrieved from https://ir.uiowa.edu/etd/5788

Chicago Manual of Style (16^th Edition):

Joshi, Madhur Satish. “Elaboration of azine and azole anhydrobases via intra- and intermolecular cyclizations for heterocycle construction.” 2017. Doctoral Dissertation, University of Iowa. Accessed March 06, 2021. https://ir.uiowa.edu/etd/5788.

MLA Handbook (7^th Edition):

Joshi, Madhur Satish. “Elaboration of azine and azole anhydrobases via intra- and intermolecular cyclizations for heterocycle construction.” 2017. Web. 06 Mar 2021.

Vancouver:

Joshi MS. Elaboration of azine and azole anhydrobases via intra- and intermolecular cyclizations for heterocycle construction. [Internet] [Doctoral dissertation]. University of Iowa; 2017. [cited 2021 Mar 06]. Available from: https://ir.uiowa.edu/etd/5788.

Council of Science Editors:

Joshi MS. Elaboration of azine and azole anhydrobases via intra- and intermolecular cyclizations for heterocycle construction. [Doctoral Dissertation]. University of Iowa; 2017. Available from: https://ir.uiowa.edu/etd/5788

University of Southern California

15. Jarusiewicz, Jamie A. Synthesis of protein-protein interaction inhibitors and development of new catalytic methods.

Degree: PhD, Chemistry, 2012, University of Southern California

URL: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/80293/rec/6294

► This dissertation comprises three projects, two related to the synthesis and evaluation of small molecule inhibitors of protein-protein interactions, and one related to development of… (more)

Subjects/Keywords: organic synthesis; Heck reaction; Strecker reaction; N-heterocyclic carbenes; BCL-2 inhibitors; MEF2

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APA (6^th Edition):

Jarusiewicz, J. A. (2012). Synthesis of protein-protein interaction inhibitors and development of new catalytic methods. (Doctoral Dissertation). University of Southern California. Retrieved from http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/80293/rec/6294

Chicago Manual of Style (16^th Edition):

Jarusiewicz, Jamie A. “Synthesis of protein-protein interaction inhibitors and development of new catalytic methods.” 2012. Doctoral Dissertation, University of Southern California. Accessed March 06, 2021. http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/80293/rec/6294.

MLA Handbook (7^th Edition):

Jarusiewicz, Jamie A. “Synthesis of protein-protein interaction inhibitors and development of new catalytic methods.” 2012. Web. 06 Mar 2021.

Vancouver:

Jarusiewicz JA. Synthesis of protein-protein interaction inhibitors and development of new catalytic methods. [Internet] [Doctoral dissertation]. University of Southern California; 2012. [cited 2021 Mar 06]. Available from: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/80293/rec/6294.

Council of Science Editors:

Jarusiewicz JA. Synthesis of protein-protein interaction inhibitors and development of new catalytic methods. [Doctoral Dissertation]. University of Southern California; 2012. Available from: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/80293/rec/6294

Universidade Estadual de Campinas

16. Penha, Eduardo Tanoue da, 1980-. Estudo computacional do mecanismo da reação de Heck-Matsuda e aplicação sintética: Computational study of the Heck-Matsuda reaction mechanism and synthetic application.

Degree: 2015, Universidade Estadual de Campinas

URL: http://repositorio.unicamp.br/jspui/handle/REPOSIP/249874

► Abstract: This thesis has two subjects: the first one entitled "Mechanistic study of the Heck-Matsuda reaction", comprised a computational study of the Heck reaction using… (more)

▼ Abstract: This thesis has two subjects: the first one entitled "Mechanistic study of the Heck-Matsuda reaction", comprised a computational study of the Heck reaction using arenediazonium salts at B3LYP/6-31G* level of theory. The main steps of the catalytic cycle in cationic, anionic and neutral route were modeled. The theoretical results showed that oxidative addition step had the higher energy barrier of the routes aforementioned. In addition, the results indicated a possible competition between the cationic and neutral routes. It was found that cationic route gave two transition states: the first one, characterized by palladium attack to the beta nitrogen of the diazonium function and the other by coordination of palladium to carbon (ipso) ¿ nitrogen (alpha) of the diazonium function. The functional influence and solvent effects were studied at M06/6-31G* level of theory and the results were in accordance with B3LYP results. The second subject entitled "Methodological development of Heck-Matsuda coupling employing ortho-carboxybenzenodiazonium salt and correlates" included the preparation of the 3,4-dihydroisocoumarins and phthalides moieties in one pot procedure. The results showed that lactone size was induced by electronic factor: 6-membered rings were induced by electron donating groups and 5 membered rings, by electron attracting groups. The one pot procedure was achieved for some substrates whilst others was accomplished by an acidic or basic medium. The experimental protocol proved to be simple and robust, affording yields in the range of 49% - 99% Advisors/Committee Members: UNIVERSIDADE ESTADUAL DE CAMPINAS (CRUESP), Correia, Carlos Roque Duarte, 1953- (advisor), Universidade Estadual de Campinas. Instituto de Química (institution), Programa de Pós-Graduação em Química (nameofprogram), Steil, Leonardo Jose (committee member), Imamura, Paulo Mitsuo (committee member), Salles Junior, Airton Gonçalves (committee member), Esteves, Pierre Mothé (committee member).

Subjects/Keywords: Heck-Matsuda, reação de; Cálculos teóricos; 3,4-diidroisocumarina; Ftalídeo; Heck-Matsuda reaction; Theoretical calculations; 3,4-dihydroisocoumarin; Phthalide

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APA (6^th Edition):

Penha, Eduardo Tanoue da, 1. (2015). Estudo computacional do mecanismo da reação de Heck-Matsuda e aplicação sintética: Computational study of the Heck-Matsuda reaction mechanism and synthetic application. (Thesis). Universidade Estadual de Campinas. Retrieved from http://repositorio.unicamp.br/jspui/handle/REPOSIP/249874

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Penha, Eduardo Tanoue da, 1980-. “Estudo computacional do mecanismo da reação de Heck-Matsuda e aplicação sintética: Computational study of the Heck-Matsuda reaction mechanism and synthetic application.” 2015. Thesis, Universidade Estadual de Campinas. Accessed March 06, 2021. http://repositorio.unicamp.br/jspui/handle/REPOSIP/249874.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Penha, Eduardo Tanoue da, 1980-. “Estudo computacional do mecanismo da reação de Heck-Matsuda e aplicação sintética: Computational study of the Heck-Matsuda reaction mechanism and synthetic application.” 2015. Web. 06 Mar 2021.

Vancouver:

Penha, Eduardo Tanoue da 1. Estudo computacional do mecanismo da reação de Heck-Matsuda e aplicação sintética: Computational study of the Heck-Matsuda reaction mechanism and synthetic application. [Internet] [Thesis]. Universidade Estadual de Campinas; 2015. [cited 2021 Mar 06]. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/249874.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Penha, Eduardo Tanoue da 1. Estudo computacional do mecanismo da reação de Heck-Matsuda e aplicação sintética: Computational study of the Heck-Matsuda reaction mechanism and synthetic application. [Thesis]. Universidade Estadual de Campinas; 2015. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/249874

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universidade Estadual de Campinas

17. Carmona, Rafaela Costa, 1988-. Novas aplicações da reação de Heck enantiosseletiva : dessimetrizações e reações intramoleculares: New applications of the enantioselective Heck reaction : desymmetrizations and intramolecular reactions.

Degree: 2018, Universidade Estadual de Campinas

URL: http://repositorio.unicamp.br/jspui/handle/REPOSIP/331977

► Abstract: The Heck reaction is considered a very efficient method for the formation of carbon-carbon bonds and one of the most used transformations in organic… (more)

▼ Abstract: The Heck reaction is considered a very efficient method for the formation of carbon-carbon bonds and one of the most used transformations in organic synthesis. The use of arenediazonium salts as electrophiles, known as the Heck-Matsuda reaction, is increasingly contributing to the synthesis of valuable compounds in a practical and efficient way. This doctoral thesis presents the development and evolution of the enantioselective Heck-Matsuda reaction for the synthesis of carbo- and heterocycles. First, the desymmetrization of cis-4-cyclopentene-1,3-diol was studied, leading to the formation of 3-hydroxy-4-arylcyclopentanones and 4-arylcyclopentenones in excellent yield and in a diastereo- and enantioselective manner. The products obtained are considered important synthetic building blocks for the synthesis of natural and unnatural bioactive compounds containing five membered rings. In the sequence, an enantioselective Heck desymmetrization reaction was developed for the synthesis of heterocyclic compounds containing two stereogenic centers, one at the heteroatom (S and P) and the other at the carbon. The selected prochiral symmetrical substrates were efficiently arylated using the PyraBOx chiral ligand and a variety of aryl sulfones, sulfoxides and five-membered phosphine oxides were obtained in excellent yields, good diastereoselectivities and enantiomeric ratios of up to 98:2. Furthermore, the developed methodology is extremely simple and based on an unprecedented non-covalent director effect of S=O and P=O functionalities. The development of the intramolecular Heck-Matsuda asymmetric reaction poses an extra challenge due to the instability of the arenediazonium salt and the rapid formation of styrenes and/or aromatization of the intermediate. However, this issue could be overcome by capturing the alkyl-palladium intermediate formed with nucleophiles. In this way, this methodology was developed and the first examples of the asymmetric Heck-Matsuda cascade reaction are being reported in this work. In addition, during an internship abroad, the development of the cascade aza-Heck reaction was carried out leading to the formation of functionalized heterocycles Advisors/Committee Members: UNIVERSIDADE ESTADUAL DE CAMPINAS (CRUESP), Correia, Carlos Roque Duarte, 1953- (advisor), Universidade Estadual de Campinas. Instituto de Química (institution), Programa de Pós-Graduação em Química (nameofprogram), Corrêa, Arlene Gonçalves (committee member), Raminelli, Cristiano (committee member), Jurberg, Igor Dias (committee member), Pastre, Júlio Cezar (committee member).

Subjects/Keywords: Catálise enantiosseletiva; Reação de Heck; Sais de arenodiazônio; Paládio; Enantioselective catalysis; Heck reaction; Arenediazonium salts; Palladium

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APA (6^th Edition):

Carmona, Rafaela Costa, 1. (2018). Novas aplicações da reação de Heck enantiosseletiva : dessimetrizações e reações intramoleculares: New applications of the enantioselective Heck reaction : desymmetrizations and intramolecular reactions. (Thesis). Universidade Estadual de Campinas. Retrieved from http://repositorio.unicamp.br/jspui/handle/REPOSIP/331977

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Carmona, Rafaela Costa, 1988-. “Novas aplicações da reação de Heck enantiosseletiva : dessimetrizações e reações intramoleculares: New applications of the enantioselective Heck reaction : desymmetrizations and intramolecular reactions.” 2018. Thesis, Universidade Estadual de Campinas. Accessed March 06, 2021. http://repositorio.unicamp.br/jspui/handle/REPOSIP/331977.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Carmona, Rafaela Costa, 1988-. “Novas aplicações da reação de Heck enantiosseletiva : dessimetrizações e reações intramoleculares: New applications of the enantioselective Heck reaction : desymmetrizations and intramolecular reactions.” 2018. Web. 06 Mar 2021.

Vancouver:

Carmona, Rafaela Costa 1. Novas aplicações da reação de Heck enantiosseletiva : dessimetrizações e reações intramoleculares: New applications of the enantioselective Heck reaction : desymmetrizations and intramolecular reactions. [Internet] [Thesis]. Universidade Estadual de Campinas; 2018. [cited 2021 Mar 06]. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/331977.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Carmona, Rafaela Costa 1. Novas aplicações da reação de Heck enantiosseletiva : dessimetrizações e reações intramoleculares: New applications of the enantioselective Heck reaction : desymmetrizations and intramolecular reactions. [Thesis]. Universidade Estadual de Campinas; 2018. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/331977

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universidade Estadual de Campinas

18. Martinez, Pablo David Grigol, 1979-. Enecarbamatos endocíclicos como substratos na organocatálise : abordagens para a síntese de bases esfingóides e análogo da bulgecinina: Endocyclic enecarbamates as substrates in organocatalysis : approaches to sphingoid bases synthesis and bulgecinine analogue.

Degree: 2013, Universidade Estadual de Campinas

URL: http://repositorio.unicamp.br/jspui/handle/REPOSIP/249473

► Abstract: In the first part of this work, the use of endocyclic enecarbamates as substrates in organocatalysis was evaluated. The effect of phosphoric acids as… (more)

Subjects/Keywords: Enecarbamatos; Bases esfingoides; Heck-Matsuda, reação de; Hidrogenólise; Organocatálise; Enecarbamates; Sphingoid bases; Heck-Matsuda reaction; Hydrogenolysis; Organocatalysis

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Martinez, Pablo David Grigol, 1. (2013). Enecarbamatos endocíclicos como substratos na organocatálise : abordagens para a síntese de bases esfingóides e análogo da bulgecinina: Endocyclic enecarbamates as substrates in organocatalysis : approaches to sphingoid bases synthesis and bulgecinine analogue. (Thesis). Universidade Estadual de Campinas. Retrieved from http://repositorio.unicamp.br/jspui/handle/REPOSIP/249473

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Martinez, Pablo David Grigol, 1979-. “Enecarbamatos endocíclicos como substratos na organocatálise : abordagens para a síntese de bases esfingóides e análogo da bulgecinina: Endocyclic enecarbamates as substrates in organocatalysis : approaches to sphingoid bases synthesis and bulgecinine analogue.” 2013. Thesis, Universidade Estadual de Campinas. Accessed March 06, 2021. http://repositorio.unicamp.br/jspui/handle/REPOSIP/249473.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Martinez, Pablo David Grigol, 1979-. “Enecarbamatos endocíclicos como substratos na organocatálise : abordagens para a síntese de bases esfingóides e análogo da bulgecinina: Endocyclic enecarbamates as substrates in organocatalysis : approaches to sphingoid bases synthesis and bulgecinine analogue.” 2013. Web. 06 Mar 2021.

Vancouver:

Martinez, Pablo David Grigol 1. Enecarbamatos endocíclicos como substratos na organocatálise : abordagens para a síntese de bases esfingóides e análogo da bulgecinina: Endocyclic enecarbamates as substrates in organocatalysis : approaches to sphingoid bases synthesis and bulgecinine analogue. [Internet] [Thesis]. Universidade Estadual de Campinas; 2013. [cited 2021 Mar 06]. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/249473.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Martinez, Pablo David Grigol 1. Enecarbamatos endocíclicos como substratos na organocatálise : abordagens para a síntese de bases esfingóides e análogo da bulgecinina: Endocyclic enecarbamates as substrates in organocatalysis : approaches to sphingoid bases synthesis and bulgecinine analogue. [Thesis]. Universidade Estadual de Campinas; 2013. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/249473

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

19. Dumonteil, Geoffrey. Synthèse et pharmacomodulations de composés naturels issus de plantes : Synthèse et pharmacomodulations de composés naturels issus de plantes.

Degree: Docteur es, Chimie, 2015, Université d'Orléans

URL: http://www.theses.fr/2015ORLE2061

►

Les motifs polyènes constituent une fonction importante parmi les composés organiques et sont présents dans de nombreux composés naturels sous la forme de diènes 1,3-conjugués.… (more)

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Les motifs polyènes constituent une fonction importante parmi les composés organiques et sont présents dans de nombreux composés naturels sous la forme de diènes 1,3-conjugués. Il est donc essentiel de mettre au point des méthodes permettant d’accéder à ces diènes tout en portant un regard attentif à l’impact environnemental. Au cours de ces travaux, nous avons pu synthétiser un composé naturel ayant une incidence sur le diabète de type II : l’acide abscissique. L’étape clef conduisant au succès de cette synthèse est la réaction de Heck. A partir de ces résultats, nous avons mis au point une méthode robuste et efficace pour obtenir divers composés diéniques (E,Z) et triéniques (E,E,Z) en s’affranchissant d’utiliser des ligands ou un solvant. Les composés ainsi obtenus sont envisagés comme potentiels analogues de l’acide abscissique et sont engagés dans diverses réactions afin d’essayer d’obtenir l’acide carboxylique correspondant ou un bioisostère de ce dernier. En parallèle, nous avons mis au point une voie d’accès à des composés de type benzo[d]thiazole substitués en position 2 par un groupement N-aryle ou N-alkyle. Cette méthodologie de synthèse s’inscrit dans un contexte d’écocompatibilité par l’utilisation d’une catalyse au diiode.

Polyene units constitute an important function from organic compounds and are present in many natural products in the form of 1,3-conjugated dienes. It is therefore essential to develop methods to access these dienes while wearing a careful look at the environmental impact. During this work, we were able to synthesize a natural compound which has activity on type II diabetes: the abscisic acid. The key step leading to the success of this synthesis is the Heck reaction. From these results, we have developed a robust and efficient method to obtain various diene compounds (E, Z) and trienes (E, E, Z) without ligand or solvent. The compounds thus obtained are considered as potential analogues of the abscisic acid and are involved in various reactions in order to obtain the corresponding carboxylic acid or its bioisostere. In parallel with this synthesis application, we have developed a pathway to obtain benzo[d]thiazole compounds substituted in position 2 with an N-aryl or N-alkyl. This synthetic methodology is part of a context of environmental compatibility by using iodine catalyst.

Advisors/Committee Members: Berteina-Raboin, Sabine (thesis director).

Subjects/Keywords: Chimie verte; Produit naturel; Réaction de Heck; Catalyse à l’iode; Green chemistry; Natural product; Heck reaction; Iodine catalyst; 547

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Dumonteil, G. (2015). Synthèse et pharmacomodulations de composés naturels issus de plantes : Synthèse et pharmacomodulations de composés naturels issus de plantes. (Doctoral Dissertation). Université d'Orléans. Retrieved from http://www.theses.fr/2015ORLE2061

Chicago Manual of Style (16^th Edition):

Dumonteil, Geoffrey. “Synthèse et pharmacomodulations de composés naturels issus de plantes : Synthèse et pharmacomodulations de composés naturels issus de plantes.” 2015. Doctoral Dissertation, Université d'Orléans. Accessed March 06, 2021. http://www.theses.fr/2015ORLE2061.

MLA Handbook (7^th Edition):

Dumonteil, Geoffrey. “Synthèse et pharmacomodulations de composés naturels issus de plantes : Synthèse et pharmacomodulations de composés naturels issus de plantes.” 2015. Web. 06 Mar 2021.

Vancouver:

Dumonteil G. Synthèse et pharmacomodulations de composés naturels issus de plantes : Synthèse et pharmacomodulations de composés naturels issus de plantes. [Internet] [Doctoral dissertation]. Université d'Orléans; 2015. [cited 2021 Mar 06]. Available from: http://www.theses.fr/2015ORLE2061.

Council of Science Editors:

Dumonteil G. Synthèse et pharmacomodulations de composés naturels issus de plantes : Synthèse et pharmacomodulations de composés naturels issus de plantes. [Doctoral Dissertation]. Université d'Orléans; 2015. Available from: http://www.theses.fr/2015ORLE2061

20. Grüber, Raymond. Etude théorique de réactions de Heck intramoléculaires : Theoretical study of intramolecular Heck reactions.

Degree: Docteur es, Chimie, 2014, Lyon, École normale supérieure

URL: http://www.theses.fr/2014ENSL0906

►

L'ouverture de cycle aromatique catalysée par le palladium a été récemment observée par une équipe de l'ENSTA. Ce type de réactivité du palladium n’a jamais… (more)

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L'ouverture de cycle aromatique catalysée par le palladium a été récemment observée par une équipe de l'ENSTA. Ce type de réactivité du palladium n’a jamais été observé auparavant et entre en compétition avec l’activation C-H classique. Ce travail de thèse a consisté à étudier ces réactions d'un point de vue théorique pour mieux en comprendre les mécanismes.Nous avons tout d'abord cherché la fonctionnelle permettant la meilleure description de la compétition entre la complexation azote/alcène en comparant plus de soixante fonctionnelles à des calculs CCSD(T)/CBS. Nous avons retenu la fonctionnelle GGA BP86.Nous avons ensuite étudié la réaction de Heck intramoléculaire à partir de la N-allyl-2-iodo-aniline. Nous avons justifié que l'indole soit le produit majoritairement obtenu, et montré que l'azote ne joue pas de rôle sur la régiosélectivité. Cependant, dans certains cas, l'azote inhibe la réaction en piégeant le complexe de palladium. Une étude théorique a montré que le facteur prépondérant de cette inhibition est la population électronique de l'azote et non l'hybridation du carbone benzylique.L'ouverture du furane a été ensuite considérée. Parmi tous les mécanismes proposés, notre étude théorique a montré que la voie principale est celle de la β-alkoxyelimination, potentiellement assistée par la trialkylamine présente dans le milieu.Enfin, nous avons étudié l'ouverture du benzylfurfurylaniline. Le mécanisme est similaire à celui observé pour l'ouverture du furane jusqu'à la régénération du complexe de palladium catalytique. En effet, dans le ce cas, la base azotée joue le rôle d'un donneur de proton.

Aromatic cyclic compound opening catalyzed by palladium has been recently observed by ENSTA team. That kind of reactivité for palladium has not been shown before and is in competition with the C-H activation. This work studies theses reactions from a theoretical point of view to better understand the mechanisms. We first look for the functional who gives the best description of the competition between the nitrogen/alkene complexation comparing more than sixty functionals with CCSD(T)/CBS calculation. We choose at last the GGA functional BP86.We then study the intramolecular Heck reaction starting from the N-allyl-2-iodo-aniline. We justified that the indole moiety was the major product and showed that the nitrogen plays no rôle in the regioselectivity.However, in some cases, the nitrogen inhibits the reaction by trapping the palladium complex. A theoretical study showed that the main factor for this inhibition was the population of nitrogen lone pair and not the hybridation of the benzylic carbon.Furan opening was then considered. Between all the mechanisms proposed, our theoretical study showed that the main way is the β-alkoxyelimination, potentially assisted by the trialkylamine present in the environment.Finally, we have studied the benzylfurfurylaniline opening. The mechanism is similar to the one observed for the furan opening until the regeneration of the palladium complex. Indeed, in that case, the base…

Advisors/Committee Members: Fleurat-Lessard, Paul (thesis director).

Subjects/Keywords: Réaction de Heck; Ouverture furane; Benzofurane; Fonctionnelle; Catalyse; DFT; Mécanisme; Heck reaction; Furan opening; Benzofuran; Functional; Catalysis; DFT; Mechanism

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Grüber, R. (2014). Etude théorique de réactions de Heck intramoléculaires : Theoretical study of intramolecular Heck reactions. (Doctoral Dissertation). Lyon, École normale supérieure. Retrieved from http://www.theses.fr/2014ENSL0906

Chicago Manual of Style (16^th Edition):

Grüber, Raymond. “Etude théorique de réactions de Heck intramoléculaires : Theoretical study of intramolecular Heck reactions.” 2014. Doctoral Dissertation, Lyon, École normale supérieure. Accessed March 06, 2021. http://www.theses.fr/2014ENSL0906.

MLA Handbook (7^th Edition):

Grüber, Raymond. “Etude théorique de réactions de Heck intramoléculaires : Theoretical study of intramolecular Heck reactions.” 2014. Web. 06 Mar 2021.

Vancouver:

Grüber R. Etude théorique de réactions de Heck intramoléculaires : Theoretical study of intramolecular Heck reactions. [Internet] [Doctoral dissertation]. Lyon, École normale supérieure; 2014. [cited 2021 Mar 06]. Available from: http://www.theses.fr/2014ENSL0906.

Council of Science Editors:

Grüber R. Etude théorique de réactions de Heck intramoléculaires : Theoretical study of intramolecular Heck reactions. [Doctoral Dissertation]. Lyon, École normale supérieure; 2014. Available from: http://www.theses.fr/2014ENSL0906

Université Paris-Sud – Paris XI

21. Piou, Tiffany. Développement de nouvelles réactions domino impliquant une étape de fonctionnalisation C-H pour la synthèse d'hétérocycles : Development of new domino reactions involving C-H functionalization for the synthesis of heterocycles.

Degree: Docteur es, Chimie organique, 2012, Université Paris-Sud – Paris XI

URL: http://www.theses.fr/2012PA112424

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Le projet scientifique a consisté au développement de nouveaux processus domino ayant pour étape clé la fonctionnalisation d’une liaison C-H. L’introduction de cette étape de… (more)

Subjects/Keywords: Réactions domino; Palladium; Oxindole; Activation C-H, Heck; Réaction Heck; Aminopalladation; Migration; Hétérocycle; Catalyse; Domino reactions; Palladium; Oxindole; C-H activation; Heck reaction; Aminopalladation; Migration; Heterocycles; Catalysis

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Piou, T. (2012). Développement de nouvelles réactions domino impliquant une étape de fonctionnalisation C-H pour la synthèse d'hétérocycles : Development of new domino reactions involving C-H functionalization for the synthesis of heterocycles. (Doctoral Dissertation). Université Paris-Sud – Paris XI. Retrieved from http://www.theses.fr/2012PA112424

Chicago Manual of Style (16^th Edition):

Piou, Tiffany. “Développement de nouvelles réactions domino impliquant une étape de fonctionnalisation C-H pour la synthèse d'hétérocycles : Development of new domino reactions involving C-H functionalization for the synthesis of heterocycles.” 2012. Doctoral Dissertation, Université Paris-Sud – Paris XI. Accessed March 06, 2021. http://www.theses.fr/2012PA112424.

MLA Handbook (7^th Edition):

Piou, Tiffany. “Développement de nouvelles réactions domino impliquant une étape de fonctionnalisation C-H pour la synthèse d'hétérocycles : Development of new domino reactions involving C-H functionalization for the synthesis of heterocycles.” 2012. Web. 06 Mar 2021.

Vancouver:

Piou T. Développement de nouvelles réactions domino impliquant une étape de fonctionnalisation C-H pour la synthèse d'hétérocycles : Development of new domino reactions involving C-H functionalization for the synthesis of heterocycles. [Internet] [Doctoral dissertation]. Université Paris-Sud – Paris XI; 2012. [cited 2021 Mar 06]. Available from: http://www.theses.fr/2012PA112424.

Council of Science Editors:

Piou T. Développement de nouvelles réactions domino impliquant une étape de fonctionnalisation C-H pour la synthèse d'hétérocycles : Development of new domino reactions involving C-H functionalization for the synthesis of heterocycles. [Doctoral Dissertation]. Université Paris-Sud – Paris XI; 2012. Available from: http://www.theses.fr/2012PA112424

Universidade Estadual de Campinas

22. Frota, Carlise, 1987-. Arilação de Heck-Matsuda em olefinas trissubstituídas : estudo metodológico e aplicação na síntese do meso-hexestrol: Heck-Matsuda arylation in trisubstituted olefins : methodological study and application in meso-hexestrol synthesis.

Degree: 2018, Universidade Estadual de Campinas

URL: http://repositorio.unicamp.br/jspui/handle/REPOSIP/331861

► Abstract: The present work had as general objective the methodological study of the Heck-Matsuda reaction in trisubstituted olefins and its synthetic application. In the first… (more)

Subjects/Keywords: Heck-Matsuda, reação de; Paládio; Reação regiosseletiva; Reação diastereosseletiva; Sais de diazônio; Heck-Matsuda reaction; Palladium; Regioselective reaction; Diastereoselective reaction; Diazonium salts

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Frota, Carlise, 1. (2018). Arilação de Heck-Matsuda em olefinas trissubstituídas : estudo metodológico e aplicação na síntese do meso-hexestrol: Heck-Matsuda arylation in trisubstituted olefins : methodological study and application in meso-hexestrol synthesis. (Thesis). Universidade Estadual de Campinas. Retrieved from http://repositorio.unicamp.br/jspui/handle/REPOSIP/331861

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Frota, Carlise, 1987-. “Arilação de Heck-Matsuda em olefinas trissubstituídas : estudo metodológico e aplicação na síntese do meso-hexestrol: Heck-Matsuda arylation in trisubstituted olefins : methodological study and application in meso-hexestrol synthesis.” 2018. Thesis, Universidade Estadual de Campinas. Accessed March 06, 2021. http://repositorio.unicamp.br/jspui/handle/REPOSIP/331861.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Frota, Carlise, 1987-. “Arilação de Heck-Matsuda em olefinas trissubstituídas : estudo metodológico e aplicação na síntese do meso-hexestrol: Heck-Matsuda arylation in trisubstituted olefins : methodological study and application in meso-hexestrol synthesis.” 2018. Web. 06 Mar 2021.

Vancouver:

Frota, Carlise 1. Arilação de Heck-Matsuda em olefinas trissubstituídas : estudo metodológico e aplicação na síntese do meso-hexestrol: Heck-Matsuda arylation in trisubstituted olefins : methodological study and application in meso-hexestrol synthesis. [Internet] [Thesis]. Universidade Estadual de Campinas; 2018. [cited 2021 Mar 06]. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/331861.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Frota, Carlise 1. Arilação de Heck-Matsuda em olefinas trissubstituídas : estudo metodológico e aplicação na síntese do meso-hexestrol: Heck-Matsuda arylation in trisubstituted olefins : methodological study and application in meso-hexestrol synthesis. [Thesis]. Universidade Estadual de Campinas; 2018. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/331861

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Université Paris-Sud – Paris XI

23. Alsalim, Rana. Contribution à la synthèse totale de la céphalotaxine : Contribution to the total synthesis of cephalotaxine.

Degree: Docteur es, Chimie organique, 2013, Université Paris-Sud – Paris XI

URL: http://www.theses.fr/2013PA114811

►

Depuis plus de 40 ans des chimistes se sont intéressés à l’extraction, à l’activité biologique et à la synthèse de l’homoharringtonine, un ester naturel de… (more)

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Depuis plus de 40 ans des chimistes se sont intéressés à l’extraction, à l’activité biologique et à la synthèse de l’homoharringtonine, un ester naturel de la céphalotaxine, qui est un puissant antileucémique, en vue de son utilisation thérapeutique, en particulier contre les leucémies résistantes aux inhibiteurs de tyrosine kinase. Ces alcaloïdes sont extraits de Cephalotaxus, des conifères originaires du sud de la Chine à croissance extrêmement lente et menacés d’extinction, la synthèse de ces alcaloïdes est nécessaire pour une utilisation thérapeutique.L’objectif de ce travail consiste à développer une synthèse concise de la (-)-céphalotaxine 1, afin de palier notamment le problème de sa pureté énantiomérique variable lorsqu’elle est issue de la matière première végétale. La stratégie développée dans ce travail nécessite d’effectuer un couplage de Heck avec des substrats désactivés et encombrés. Les résultats préliminaires ayant été décevants, le première objectif à consisté à développer l’utilisation de la méthode des plans d’expérience en synthèse totale, car l’efficacité de chaque étape a une répercussion importante sur le rendement en produit final. Dans une première partie, l’application d’un plan d’expériences a permis de pallier ce problème par une étude modèle pour déterminer les paramètres importants pour effectuer une telle réaction efficacement. Dans une deuxième partie, nous avons synthétisé les précurseurs et réalisé le couplage de Heck en vue de l’accès à un précurseur AC comportant tous les atomes de carbone du squelette de la céphalotaxine et les fonctionnalités requises pour sa cyclisation ultérieure en tétracycle ABCD. Enfin, nous avons fonctionnalisé les produits de Heck en position C3 par différents méthodes. Ces résultats ont permis de valider notre stratégie de synthèse.

For more than 40 years the chemists were interested in the extraction, in the biological activity and in the synthesis of the homoharringtonine, a natural ester of cephalotaxine, which is a powerful antileukemic compound of therapeutic use, in particular against the leukaemia resistant to tyrosine kinase inhibitors. These alkaloids are extracted from Cephalotaxus, conifers native of the South of China with extremely slow growth. The objective of this work thus consisted in developing a concise synthesis of the cephalotaxine, to limit the recourse to the endangered vegetable resource The developed strategy requires an intermolecular Heck-coupling of electronically and sterically deactivated demanding substrates. The preliminary results having been disappointing, the first objective consisted in developing the use of the model of the experimental design in total synthesis because the classic methodology of variation of a single parameter at the same time said of "one by one" was ineffective. The application of a complete factorial design overcomes this problem by a model study, allowing to determine the optimized parameters to make this coupling reaction effective. We then synthesized the precursors from naturally abundant…

Advisors/Committee Members: Dumas, Françoise (thesis director).

Subjects/Keywords: Alcaloïdes; Céphalotaxine; Activité antileucémique; Synthèse totale; Réaction de Heck; Plan d’expérience; Réaction tandem Heck/oxa-Michael; Processus éco-compatible; Eau; Palladium; Hydro-arylation; Alkaloids; Cephalotaxine; Antileukemic activity; Total synthesis; Heck reaction; Experimental design; Tandem Heck/oxa-Michael reaction; Sustainable process; Water; Palladium; Hydro-arylation

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Alsalim, R. (2013). Contribution à la synthèse totale de la céphalotaxine : Contribution to the total synthesis of cephalotaxine. (Doctoral Dissertation). Université Paris-Sud – Paris XI. Retrieved from http://www.theses.fr/2013PA114811

Chicago Manual of Style (16^th Edition):

Alsalim, Rana. “Contribution à la synthèse totale de la céphalotaxine : Contribution to the total synthesis of cephalotaxine.” 2013. Doctoral Dissertation, Université Paris-Sud – Paris XI. Accessed March 06, 2021. http://www.theses.fr/2013PA114811.

MLA Handbook (7^th Edition):

Alsalim, Rana. “Contribution à la synthèse totale de la céphalotaxine : Contribution to the total synthesis of cephalotaxine.” 2013. Web. 06 Mar 2021.

Vancouver:

Alsalim R. Contribution à la synthèse totale de la céphalotaxine : Contribution to the total synthesis of cephalotaxine. [Internet] [Doctoral dissertation]. Université Paris-Sud – Paris XI; 2013. [cited 2021 Mar 06]. Available from: http://www.theses.fr/2013PA114811.

Council of Science Editors:

Alsalim R. Contribution à la synthèse totale de la céphalotaxine : Contribution to the total synthesis of cephalotaxine. [Doctoral Dissertation]. Université Paris-Sud – Paris XI; 2013. Available from: http://www.theses.fr/2013PA114811

Universidade Estadual de Campinas

24. Angnes, Ricardo Almir, 1991-. Reações enantiosseletivas de Heck em alcenos endocíclicos : uso de interações não covalentes atrativas na indução de diastereosseletividade: Enantioselective Heck reactions of endocyclic alkenes : use of attractive non-covalent interactions for the induction of diastereoselectivity.

Degree: 2019, Universidade Estadual de Campinas

URL: http://repositorio.unicamp.br/jspui/handle/REPOSIP/334705

► Abstract: The palladium catalyzed arylation of alkenes is an efficient strategy for the construction of carbon-carbon bonds. The enantioselectivity in these reactions can usually be… (more)

Subjects/Keywords: Heck-Matsuda, reação de; Catálise enantiosseletiva; Catalise por paládio; Interações não-covalentes; Reação diastereosseletiva; Heck-Matsuda reaction; Enantioselective catalysis; Palladium catalysts; Non-covalent interactions; Diastereoselective reaction

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Angnes, Ricardo Almir, 1. (2019). Reações enantiosseletivas de Heck em alcenos endocíclicos : uso de interações não covalentes atrativas na indução de diastereosseletividade: Enantioselective Heck reactions of endocyclic alkenes : use of attractive non-covalent interactions for the induction of diastereoselectivity. (Thesis). Universidade Estadual de Campinas. Retrieved from http://repositorio.unicamp.br/jspui/handle/REPOSIP/334705

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Angnes, Ricardo Almir, 1991-. “Reações enantiosseletivas de Heck em alcenos endocíclicos : uso de interações não covalentes atrativas na indução de diastereosseletividade: Enantioselective Heck reactions of endocyclic alkenes : use of attractive non-covalent interactions for the induction of diastereoselectivity.” 2019. Thesis, Universidade Estadual de Campinas. Accessed March 06, 2021. http://repositorio.unicamp.br/jspui/handle/REPOSIP/334705.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Angnes, Ricardo Almir, 1991-. “Reações enantiosseletivas de Heck em alcenos endocíclicos : uso de interações não covalentes atrativas na indução de diastereosseletividade: Enantioselective Heck reactions of endocyclic alkenes : use of attractive non-covalent interactions for the induction of diastereoselectivity.” 2019. Web. 06 Mar 2021.

Vancouver:

Angnes, Ricardo Almir 1. Reações enantiosseletivas de Heck em alcenos endocíclicos : uso de interações não covalentes atrativas na indução de diastereosseletividade: Enantioselective Heck reactions of endocyclic alkenes : use of attractive non-covalent interactions for the induction of diastereoselectivity. [Internet] [Thesis]. Universidade Estadual de Campinas; 2019. [cited 2021 Mar 06]. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/334705.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Angnes, Ricardo Almir 1. Reações enantiosseletivas de Heck em alcenos endocíclicos : uso de interações não covalentes atrativas na indução de diastereosseletividade: Enantioselective Heck reactions of endocyclic alkenes : use of attractive non-covalent interactions for the induction of diastereoselectivity. [Thesis]. Universidade Estadual de Campinas; 2019. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/334705

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

25. Lacarriere, Tatiana. Etude synthétique d’un analogue azoté de la galanthamine. : Synthetic study of a galanthamine nitrogen analogue.

Degree: Docteur es, Chimie, 2015, Université Paris-Saclay (ComUE)

URL: http://www.theses.fr/2015SACLS136

►

La synthèse de la 5-azagalanthamine, un analogue azoté de galanthamine, utilisée dans le traitement palliatif de la maladie d’Alzheimer, a été envisagée dans le cadre… (more)

▼

La synthèse de la 5-azagalanthamine, un analogue azoté de galanthamine, utilisée dans le traitement palliatif de la maladie d’Alzheimer, a été envisagée dans le cadre d’une étude de relations structure-activité. Durant cette thèse nous avons examiné quatre voies de synthèse afin d’accéder à la 5-azagalanthamine. La première voie est basée sur la réaction de Pictet-Spengler afin de fermer le dernier cycle de l’azagalanthamine. De nombreuses tentatives ont été effectuées sur différents types de substrats mais cette stratégie s’est révélée inefficace. La deuxième approche consiste en une oxydation d’anilide ortho-substitué par un groupement méthoxy, avec un réactif à base d'iode hypervalent pour accéder à une spirodiènone, un intermédiaire clé de la synthèse. En effectuant cette réaction nous n’avons pas obtenu le produit attendu, mais une 1,2-dispirodiénone, un motif inhabituel, et très rare. Après avoir optimisé les conditions réactionnelles, nous avons étudié la généralité de la réaction avec d'autres substrats. La modélisation moléculaire ainsi que des études de voltammétrie cyclique ont été réalisées (Chabaud, L.; Hromjakova, T.; Rambla, M.; Retailleau, P.; Guillou, C. Chem. Commun. 2013, 49, 11542-11544. Hromjakova, T.; Retailleau, P.; Grimaud, L.; Gandon, V.; Chabaud, L. et Guillou, C. accepté EurJOC, 2015, DOI 10.1002/ejoc.201501160).Ensuite nous avons examiné l’approche basée sur le couplage intramoléculaire pallado-catalysé. Après les premiers résultats encourageant avec le substrat modèle nous avons réalisé une optimisation des conditions réactionnelles. Une étude de généralité de la réaction avec d'autres substrats a été effectuée. Malheureusement, il s’est avéré que la substitution sur le cycle aromatique n’était pas bien tolérée conduisant à de faibles rendements. Par conséquent cette méthodologie n’a pas pu être appliquée à la synthèse de l’azagalanthamine. Dans la dernière voie de synthèse examinée nous avons repris les travaux antérieurs entrepris dans notre laboratoire concernant la réaction de Heck intramoléculaire. La diminution de la longueur de la chaîne liant les deux cycles a permis d’obtenir des résultats très prometteurs.

The synthesis of 5-azagalanthamine, the analogue of galanthamine that is used in Alzheimer treatment, was investigated for structure - activity relationship studies.During this thesis I explored four synthetic approaches with the aim of preparing the 5-azagalanthamine. The first one is based on a Pictet-Spengler reaction used for ring closure of the last cycle of azagalanthamine. We carried out many tests on various types of substrate but this strategy has proved to be ineffective. The second approach consists of an oxidation of ortho-methoxy substituted anilide by hypervalent iodine reagent to access a spirodienone, a key intermediate of the synthesis. Interestingly this reaction did not result in the expected compound but we observed the formation of an unusual motif, the 1,2-dispirodienone. After conditions optimisation we studied the scope and limitations with others…

Advisors/Committee Members: Guillou, Catherine (thesis director).

Subjects/Keywords: 5-Azagalanthamine; Pictet-Spengler; Iode hypervalent; Couplage pallado-Catalysé; Heck intramoléculaire; 5-Azagalanthamine; Pictet-Spengler reaction; Hypervalent iodine; Palladium-Catalysed intramolecular coupling; Intramolecular Heck reaction

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Lacarriere, T. (2015). Etude synthétique d’un analogue azoté de la galanthamine. : Synthetic study of a galanthamine nitrogen analogue. (Doctoral Dissertation). Université Paris-Saclay (ComUE). Retrieved from http://www.theses.fr/2015SACLS136

Chicago Manual of Style (16^th Edition):

Lacarriere, Tatiana. “Etude synthétique d’un analogue azoté de la galanthamine. : Synthetic study of a galanthamine nitrogen analogue.” 2015. Doctoral Dissertation, Université Paris-Saclay (ComUE). Accessed March 06, 2021. http://www.theses.fr/2015SACLS136.

MLA Handbook (7^th Edition):

Lacarriere, Tatiana. “Etude synthétique d’un analogue azoté de la galanthamine. : Synthetic study of a galanthamine nitrogen analogue.” 2015. Web. 06 Mar 2021.

Vancouver:

Lacarriere T. Etude synthétique d’un analogue azoté de la galanthamine. : Synthetic study of a galanthamine nitrogen analogue. [Internet] [Doctoral dissertation]. Université Paris-Saclay (ComUE); 2015. [cited 2021 Mar 06]. Available from: http://www.theses.fr/2015SACLS136.

Council of Science Editors:

Lacarriere T. Etude synthétique d’un analogue azoté de la galanthamine. : Synthetic study of a galanthamine nitrogen analogue. [Doctoral Dissertation]. Université Paris-Saclay (ComUE); 2015. Available from: http://www.theses.fr/2015SACLS136

University of Alberta

26. Lee, Jack C. H. Preparation and Synthetic Applications of Chiral Alkyl Boronates and Unsaturated Alkenyl Boronates.

Degree: PhD, Department of Chemistry, 2013, University of Alberta

URL: https://era.library.ualberta.ca/files/qn59q550n

► As Organic Chemistry evolves into the 21st Century, the goal of this discipline has altered dramatically from merely accessing target molecules to efficiently synthesizing these… (more)

▼ As Organic Chemistry evolves into the 21st Century, the goal of this discipline has altered dramatically from merely accessing target molecules to efficiently synthesizing these compounds with minimization of non-strategic functional group manipulations and interconversions. Organoboron reagents represent one of the potential solutions towards reaching this goal. These versatile compounds can either be used to construct the desired carbon−carbon bond through various cross-coupling reactions, or be converted directly to the desired functionality through different chemical reactions. Direct transformations make interconversions between different functional groups unnecessary, thus making the overall process step-economical. In this thesis, several synthetic methods were developed to synthesize chiral alkyl boronates or alkenyl boronates through metal-catalyzed chemical transformations. These methodologies are based on early introduction strategy which applies well-established synthetic protocols to substrates with a pre-installed boronyl moiety. The subsequent applications of these compounds were also investigated, leading to a variety of synthetically valuable adducts. In order to access novel chiral secondary alkyl boronates, catalytic asymmetric conjugate addition reactions of 3-boronyl -unsaturated esters with Grignard reagents were developed. Chapter 2 describes the details of optimization of this methodology and the applications of the chiral alkyl boronate products. Aiming to explore the intrinsic reactivity of enantioenriched 1,1-diboron compounds, their synthesis was accomplished for the first time by performing asymmetric conjugate borylation on 3-boronyl enoates. The resulting optically enriched 1,1-diboron compounds were found to be excellent cross-coupling partners in Suzuki-Miyaura cross-couplings, leading to chiral alkyl boronates with excellent enantioselectivity. The details of these studies are presented in Chapter 3. In order to conduct a thorough examination of substrate scope in asymmetric conjugate reductions of 3-boronyl-3-aryl -unsaturated esters, a diastereoselective protocol for the preparation of these alkenyl boronates through Heck coupling was developed. In Chapter 4, the optimization of the coupling process, the substrate scope, and the subsequent application of these alkenyl boronates are discussed. Due to the synthetic potential of cyclic alkenyl boronates, new methods for their efficient synthesis are desirable. In Chapter 5, the preparation of novel cyclic alkenyl boronates through gold-catalyzed enyne cycloisomerizations is presented.

Subjects/Keywords: Gold-catalyzed cycloisomerization; Suzuki-Miyaura cross-coupling; Chiral alkyl boronates; Heck reaction; Enantioselective conjugate addition

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Lee, J. C. H. (2013). Preparation and Synthetic Applications of Chiral Alkyl Boronates and Unsaturated Alkenyl Boronates. (Doctoral Dissertation). University of Alberta. Retrieved from https://era.library.ualberta.ca/files/qn59q550n

Chicago Manual of Style (16^th Edition):

Lee, Jack C H. “Preparation and Synthetic Applications of Chiral Alkyl Boronates and Unsaturated Alkenyl Boronates.” 2013. Doctoral Dissertation, University of Alberta. Accessed March 06, 2021. https://era.library.ualberta.ca/files/qn59q550n.

MLA Handbook (7^th Edition):

Lee, Jack C H. “Preparation and Synthetic Applications of Chiral Alkyl Boronates and Unsaturated Alkenyl Boronates.” 2013. Web. 06 Mar 2021.

Vancouver:

Lee JCH. Preparation and Synthetic Applications of Chiral Alkyl Boronates and Unsaturated Alkenyl Boronates. [Internet] [Doctoral dissertation]. University of Alberta; 2013. [cited 2021 Mar 06]. Available from: https://era.library.ualberta.ca/files/qn59q550n.

Council of Science Editors:

Lee JCH. Preparation and Synthetic Applications of Chiral Alkyl Boronates and Unsaturated Alkenyl Boronates. [Doctoral Dissertation]. University of Alberta; 2013. Available from: https://era.library.ualberta.ca/files/qn59q550n

Queens University

27. Cosman, Jennifer. Advances in Metal-Catalyzed C–H Borylation and Multicomponent Allylic Substitution Reactions .

Degree: Chemistry, 2015, Queens University

URL: http://hdl.handle.net/1974/13534

► Chapter one of this thesis describes the iridium-catalyzed ortho-selective C–H borylation reaction of tertiary benzamides. An iridium(I) complex paired with an electron-deficient phosphine ligand allows… (more)

Subjects/Keywords: multicomponent reactions ; C-H activation ; allylic substitution ; Mizoroki-Heck reaction ; iridium-catalyzed C-H borylation

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Cosman, J. (2015). Advances in Metal-Catalyzed C–H Borylation and Multicomponent Allylic Substitution Reactions . (Thesis). Queens University. Retrieved from http://hdl.handle.net/1974/13534

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Cosman, Jennifer. “Advances in Metal-Catalyzed C–H Borylation and Multicomponent Allylic Substitution Reactions .” 2015. Thesis, Queens University. Accessed March 06, 2021. http://hdl.handle.net/1974/13534.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Cosman, Jennifer. “Advances in Metal-Catalyzed C–H Borylation and Multicomponent Allylic Substitution Reactions .” 2015. Web. 06 Mar 2021.

Vancouver:

Cosman J. Advances in Metal-Catalyzed C–H Borylation and Multicomponent Allylic Substitution Reactions . [Internet] [Thesis]. Queens University; 2015. [cited 2021 Mar 06]. Available from: http://hdl.handle.net/1974/13534.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Cosman J. Advances in Metal-Catalyzed C–H Borylation and Multicomponent Allylic Substitution Reactions . [Thesis]. Queens University; 2015. Available from: http://hdl.handle.net/1974/13534

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Univerzitet u Beogradu

28. Tasić, Gordana D., 1973-. Ciklizacione reakcije alilnih alkohola katalizovane paladijumovim kompleksima.

Degree: Hemijski fakultet, 2016, Univerzitet u Beogradu

URL: https://fedorabg.bg.ac.rs/fedora/get/o:12428/bdef:Content/get

►

Hemija - Organska hemija / Chemistry - Organic Chemistry

Cilj ove doktorske disertacije bio je razvoj sintetičke metodologije za dobijanje funkcionalizovanih bicikličnih ketona čijom daljom… (more)

▼

Hemija - Organska hemija / Chemistry - Organic Chemistry

Cilj ove doktorske disertacije bio je razvoj sintetičke metodologije za dobijanje funkcionalizovanih bicikličnih ketona čijom daljom transformacijom bi bilo moguće sintetisati prirodne proizvode korialstonin i korialstonidin. Sintezu pomenutih ketona moguće je ostvariti intramolekulskom Heck-ovom reakcijom vinil-halogenida i alil-alkoholne grupe odgovarajućeg polifunkcionalizovanog ciklopentenskog derivata. Kako bi dobili uvid u faktore koji kontrolišu regioselektivnost procesa, intramolekulsku Heck-ovu reakciju najpre smo proučavali na model sistemu čijom ciklizacijom može nastati biciklični keton (azabiciklo[4.2.1]nonan). U zavisnosti od načina ciklizacije koji u odnosu na alilnu alkoholnu funkcionalnu grupu može biti egzo i endo, postoji mogućnost dobijanja regioizomernih proizvoda. Tokom ovih istraživanja utvrdjeno je da priroda grupa koje su vezane za ciklopentenov prsten (etarska ili alkoholna) utiču na regioselektivnost ciklizacije, pri čemu je moguće dobiti strukturno različite proizvode pod istim uslovima. Ciklični alilni alkoholi koji imaju zaštićenu -OH grupu u obliku etra ciklizovani su na egzo-način. Nezaštićena alkoholna grupa vodi nastanku endo-proizvoda ciklizacije tj. bicikličnog ketona. Proučavani su faktori koji usmeravaju ovaj korak sa ciljem razvoja metodologije koja omogućava kontrolisanu sintezu bicikličnih derivata. Razvijeni sintetički pristup primenjen je na odgovarajući cis-ciklizacioni prekursor sa alilalkoholnom grupom u cilju sinteze bicikličnog skeleta (azabiciklo[3.2.1]oktanon) prirodnih proizvoda korialstonina i korialstonidina. Proučavanjem reakcionog puta utvrđeno je da se ciklizacija odvijala na endo-način pri čemu su dobijena tri proizvoda u relativno dobrom prinosu. Ovom ciklizacijom očekivani proizvod nije dobijen. Iz tog razloga ciklični alilni alkohol je podvrgnut oksidaciji, a potom ciklizaciji pod reduktivnim Heck-ovim uslovima. Kao jedan od proizvoda ove ciklizacije dobijen je biciklični keton koji ima azabiciklo[3.2.1]oktanski skelet. U drugom delu istraživanja razvijen je sintetički pristup policikličnim derivatima indola koji imaju N-vinilnu grupu. Proučavane su reakcije uvođenja vinilne grupe na azotov atom indolnog prstena, kao i mogućnost anelacije dobijenih derivata reakcijom RCM...

Advisors/Committee Members: Savić, Vladimir, 1963-.

Subjects/Keywords: corialstonine; corialstonidine; bicyclo compounds; Heck reaction; regioselectivity; N-vinyl indole; isomerisation; debromoarborescidine B

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Tasić, Gordana D., 1. (2016). Ciklizacione reakcije alilnih alkohola katalizovane paladijumovim kompleksima. (Thesis). Univerzitet u Beogradu. Retrieved from https://fedorabg.bg.ac.rs/fedora/get/o:12428/bdef:Content/get

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Tasić, Gordana D., 1973-. “Ciklizacione reakcije alilnih alkohola katalizovane paladijumovim kompleksima.” 2016. Thesis, Univerzitet u Beogradu. Accessed March 06, 2021. https://fedorabg.bg.ac.rs/fedora/get/o:12428/bdef:Content/get.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Tasić, Gordana D., 1973-. “Ciklizacione reakcije alilnih alkohola katalizovane paladijumovim kompleksima.” 2016. Web. 06 Mar 2021.

Vancouver:

Tasić, Gordana D. 1. Ciklizacione reakcije alilnih alkohola katalizovane paladijumovim kompleksima. [Internet] [Thesis]. Univerzitet u Beogradu; 2016. [cited 2021 Mar 06]. Available from: https://fedorabg.bg.ac.rs/fedora/get/o:12428/bdef:Content/get.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Tasić, Gordana D. 1. Ciklizacione reakcije alilnih alkohola katalizovane paladijumovim kompleksima. [Thesis]. Univerzitet u Beogradu; 2016. Available from: https://fedorabg.bg.ac.rs/fedora/get/o:12428/bdef:Content/get

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Kansas

29. Johnson, Thomas Seals. Synthesis and Applications of Amide-Based Pd(II) NNN-pincer Complexes.

Degree: MS, Chemistry, 2016, University of Kansas

URL: http://hdl.handle.net/1808/21852

► The first project is described in Chapter 2, and details the synthesis of a series of mono- and multimetallic Pd(II) NNN-pincer complexes which—to the best… (more)

Subjects/Keywords: Chemistry; Inorganic chemistry; Organic chemistry; Catalysis; Heck Reaction; Heterobimetallic; Macrocycle; Palladium; Pincer

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Johnson, T. S. (2016). Synthesis and Applications of Amide-Based Pd(II) NNN-pincer Complexes. (Masters Thesis). University of Kansas. Retrieved from http://hdl.handle.net/1808/21852

Chicago Manual of Style (16^th Edition):

Johnson, Thomas Seals. “Synthesis and Applications of Amide-Based Pd(II) NNN-pincer Complexes.” 2016. Masters Thesis, University of Kansas. Accessed March 06, 2021. http://hdl.handle.net/1808/21852.

MLA Handbook (7^th Edition):

Johnson, Thomas Seals. “Synthesis and Applications of Amide-Based Pd(II) NNN-pincer Complexes.” 2016. Web. 06 Mar 2021.

Vancouver:

Johnson TS. Synthesis and Applications of Amide-Based Pd(II) NNN-pincer Complexes. [Internet] [Masters thesis]. University of Kansas; 2016. [cited 2021 Mar 06]. Available from: http://hdl.handle.net/1808/21852.

Council of Science Editors:

Johnson TS. Synthesis and Applications of Amide-Based Pd(II) NNN-pincer Complexes. [Masters Thesis]. University of Kansas; 2016. Available from: http://hdl.handle.net/1808/21852

Univerzitet u Beogradu

30. Bigović, Miljan R. 1984-. Alilovanje visoko-funkcionalizovanim organometalnim reagensima: 4-(brommetil)-1,3-dioksol-2-on kao sintetički ekvivalent enolata hidroksiketona.

Degree: Hemijski fakultet, 2016, Univerzitet u Beogradu

URL: https://fedorabg.bg.ac.rs/fedora/get/o:11601/bdef:Content/get

►

Prirodno-matematičke nauke - Organska hemija / Life sciences - Organic chemistry

Razvijen je novi metod alilovanja karbonilnih jedinjenja pomoću 4-(brommetil)-1,3- dioksol-2-ona, kao visoko funkcionalizovanog alilujućeg… (more)

Subjects/Keywords: allylation / indium / zinc / Barbier reaction / Heck reaction / enol carbonates / α; β-dihydroxyketones / cyclic carbonates / deprotection / isomerization

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Bigović, M. R. 1. (2016). Alilovanje visoko-funkcionalizovanim organometalnim reagensima: 4-(brommetil)-1,3-dioksol-2-on kao sintetički ekvivalent enolata hidroksiketona. (Thesis). Univerzitet u Beogradu. Retrieved from https://fedorabg.bg.ac.rs/fedora/get/o:11601/bdef:Content/get

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Bigović, Miljan R 1984-. “Alilovanje visoko-funkcionalizovanim organometalnim reagensima: 4-(brommetil)-1,3-dioksol-2-on kao sintetički ekvivalent enolata hidroksiketona.” 2016. Thesis, Univerzitet u Beogradu. Accessed March 06, 2021. https://fedorabg.bg.ac.rs/fedora/get/o:11601/bdef:Content/get.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Bigović, Miljan R 1984-. “Alilovanje visoko-funkcionalizovanim organometalnim reagensima: 4-(brommetil)-1,3-dioksol-2-on kao sintetički ekvivalent enolata hidroksiketona.” 2016. Web. 06 Mar 2021.

Vancouver:

Bigović MR1. Alilovanje visoko-funkcionalizovanim organometalnim reagensima: 4-(brommetil)-1,3-dioksol-2-on kao sintetički ekvivalent enolata hidroksiketona. [Internet] [Thesis]. Univerzitet u Beogradu; 2016. [cited 2021 Mar 06]. Available from: https://fedorabg.bg.ac.rs/fedora/get/o:11601/bdef:Content/get.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Bigović MR1. Alilovanje visoko-funkcionalizovanim organometalnim reagensima: 4-(brommetil)-1,3-dioksol-2-on kao sintetički ekvivalent enolata hidroksiketona. [Thesis]. Univerzitet u Beogradu; 2016. Available from: https://fedorabg.bg.ac.rs/fedora/get/o:11601/bdef:Content/get

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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Open Access Theses and Dissertations