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Dept: Medicinal Chemistry

You searched for subject:(Health Sciences General). Showing records 1 – 13 of 13 total matches.

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University of Michigan

1. Emanuele, Anthony A. An Antibiotic Discovery Campaign Targeting VirF, the Main Transcriptional Regulator of Virulence in Shigella flexneri.

Degree: PhD, Medicinal Chemistry, 2016, University of Michigan

 Shigella flexneri is a gram-negative enteropathogen that infects the human colonic epithelium. It is estimated that Shigella spp. infect 165 million people a year worldwide.… (more)

Subjects/Keywords: Antibiotic Discovery Campaign; Shigella; Anti-virulence; VirF; Biological Chemistry; Microbiology and Immunology; Pharmacy and Pharmacology; Chemistry; Science (General); Health Sciences; Science

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APA (6th Edition):

Emanuele, A. A. (2016). An Antibiotic Discovery Campaign Targeting VirF, the Main Transcriptional Regulator of Virulence in Shigella flexneri. (Doctoral Dissertation). University of Michigan. Retrieved from http://hdl.handle.net/2027.42/120884

Chicago Manual of Style (16th Edition):

Emanuele, Anthony A. “An Antibiotic Discovery Campaign Targeting VirF, the Main Transcriptional Regulator of Virulence in Shigella flexneri.” 2016. Doctoral Dissertation, University of Michigan. Accessed January 15, 2019. http://hdl.handle.net/2027.42/120884.

MLA Handbook (7th Edition):

Emanuele, Anthony A. “An Antibiotic Discovery Campaign Targeting VirF, the Main Transcriptional Regulator of Virulence in Shigella flexneri.” 2016. Web. 15 Jan 2019.

Vancouver:

Emanuele AA. An Antibiotic Discovery Campaign Targeting VirF, the Main Transcriptional Regulator of Virulence in Shigella flexneri. [Internet] [Doctoral dissertation]. University of Michigan; 2016. [cited 2019 Jan 15]. Available from: http://hdl.handle.net/2027.42/120884.

Council of Science Editors:

Emanuele AA. An Antibiotic Discovery Campaign Targeting VirF, the Main Transcriptional Regulator of Virulence in Shigella flexneri. [Doctoral Dissertation]. University of Michigan; 2016. Available from: http://hdl.handle.net/2027.42/120884


University of Michigan

2. Johnson, Taylor. Combining Active Site and Allosteric Inhibitors to Study Protein Tyrosine Kinases.

Degree: PhD, Medicinal Chemistry, 2016, University of Michigan

 Kinases play a crucial role in a variety of cell signaling pathways that control processes such as: growth, motility, and angiogenesis. Not surprisingly, dysregulation of… (more)

Subjects/Keywords: bivalent kinase inhibitors; synergy between allosteric and active site inhibitrs; Biological Chemistry; Pharmacy and Pharmacology; Chemistry; Science (General); Health Sciences; Science

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APA (6th Edition):

Johnson, T. (2016). Combining Active Site and Allosteric Inhibitors to Study Protein Tyrosine Kinases. (Doctoral Dissertation). University of Michigan. Retrieved from http://hdl.handle.net/2027.42/135923

Chicago Manual of Style (16th Edition):

Johnson, Taylor. “Combining Active Site and Allosteric Inhibitors to Study Protein Tyrosine Kinases.” 2016. Doctoral Dissertation, University of Michigan. Accessed January 15, 2019. http://hdl.handle.net/2027.42/135923.

MLA Handbook (7th Edition):

Johnson, Taylor. “Combining Active Site and Allosteric Inhibitors to Study Protein Tyrosine Kinases.” 2016. Web. 15 Jan 2019.

Vancouver:

Johnson T. Combining Active Site and Allosteric Inhibitors to Study Protein Tyrosine Kinases. [Internet] [Doctoral dissertation]. University of Michigan; 2016. [cited 2019 Jan 15]. Available from: http://hdl.handle.net/2027.42/135923.

Council of Science Editors:

Johnson T. Combining Active Site and Allosteric Inhibitors to Study Protein Tyrosine Kinases. [Doctoral Dissertation]. University of Michigan; 2016. Available from: http://hdl.handle.net/2027.42/135923


University of Michigan

3. Bell, Jessica L. Novel Modulators of Rho Transcriptional Signaling in Cancer.

Degree: PhD, Medicinal Chemistry, 2012, University of Michigan

 Rho A and Rho C, members of the Rho GTPase family, have been found to have important roles in the metastases of multiple cancers, including… (more)

Subjects/Keywords: Metastasis; Prostate Cancer; RhoA; Medicinal Chemistry; Biological Chemistry; Medicine (General); Pharmacy and Pharmacology; Chemistry; Health Sciences; Science

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APA (6th Edition):

Bell, J. L. (2012). Novel Modulators of Rho Transcriptional Signaling in Cancer. (Doctoral Dissertation). University of Michigan. Retrieved from http://hdl.handle.net/2027.42/96163

Chicago Manual of Style (16th Edition):

Bell, Jessica L. “Novel Modulators of Rho Transcriptional Signaling in Cancer.” 2012. Doctoral Dissertation, University of Michigan. Accessed January 15, 2019. http://hdl.handle.net/2027.42/96163.

MLA Handbook (7th Edition):

Bell, Jessica L. “Novel Modulators of Rho Transcriptional Signaling in Cancer.” 2012. Web. 15 Jan 2019.

Vancouver:

Bell JL. Novel Modulators of Rho Transcriptional Signaling in Cancer. [Internet] [Doctoral dissertation]. University of Michigan; 2012. [cited 2019 Jan 15]. Available from: http://hdl.handle.net/2027.42/96163.

Council of Science Editors:

Bell JL. Novel Modulators of Rho Transcriptional Signaling in Cancer. [Doctoral Dissertation]. University of Michigan; 2012. Available from: http://hdl.handle.net/2027.42/96163


University of Michigan

4. Burke, Fernanda Ferraccioli Marques. Synthesis and Characterization of Novel Unnatural Peptide Inhibitors of Thrombin Activation of Platelet Aggregation.

Degree: PhD, Medicinal Chemistry, 2007, University of Michigan

 Inhibitors of the activation of platelet aggregation have promise as important therapeutic agents for the management of acute coronary syndrome. Platelet activation by thrombin occurs… (more)

Subjects/Keywords: Novel Peptide Inhibitors of Thrombin and PARs; Medicine (General); Health Sciences

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APA (6th Edition):

Burke, F. F. M. (2007). Synthesis and Characterization of Novel Unnatural Peptide Inhibitors of Thrombin Activation of Platelet Aggregation. (Doctoral Dissertation). University of Michigan. Retrieved from http://hdl.handle.net/2027.42/57691

Chicago Manual of Style (16th Edition):

Burke, Fernanda Ferraccioli Marques. “Synthesis and Characterization of Novel Unnatural Peptide Inhibitors of Thrombin Activation of Platelet Aggregation.” 2007. Doctoral Dissertation, University of Michigan. Accessed January 15, 2019. http://hdl.handle.net/2027.42/57691.

MLA Handbook (7th Edition):

Burke, Fernanda Ferraccioli Marques. “Synthesis and Characterization of Novel Unnatural Peptide Inhibitors of Thrombin Activation of Platelet Aggregation.” 2007. Web. 15 Jan 2019.

Vancouver:

Burke FFM. Synthesis and Characterization of Novel Unnatural Peptide Inhibitors of Thrombin Activation of Platelet Aggregation. [Internet] [Doctoral dissertation]. University of Michigan; 2007. [cited 2019 Jan 15]. Available from: http://hdl.handle.net/2027.42/57691.

Council of Science Editors:

Burke FFM. Synthesis and Characterization of Novel Unnatural Peptide Inhibitors of Thrombin Activation of Platelet Aggregation. [Doctoral Dissertation]. University of Michigan; 2007. Available from: http://hdl.handle.net/2027.42/57691


University of Michigan

5. Lee, Adam C. SMARTS Approach to Chemical Data Mining and Physicochemical Property Prediction.

Degree: PhD, Medicinal Chemistry, 2009, University of Michigan

 The calculation of physicochemical and biological properties is essential in order to facilitate modern drug discovery. Chemical spaces dimensionalized by these descriptors have been used… (more)

Subjects/Keywords: Cheminformatics; Chemoinformatics; Chemical Data Mining; Physicochemical Property Prediction; Chemical Spaces; Drug Discovery; Computer Science; Pharmacy and Pharmacology; Chemistry; Science (General); Engineering; Health Sciences; Science

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APA (6th Edition):

Lee, A. C. (2009). SMARTS Approach to Chemical Data Mining and Physicochemical Property Prediction. (Doctoral Dissertation). University of Michigan. Retrieved from http://hdl.handle.net/2027.42/64627

Chicago Manual of Style (16th Edition):

Lee, Adam C. “SMARTS Approach to Chemical Data Mining and Physicochemical Property Prediction.” 2009. Doctoral Dissertation, University of Michigan. Accessed January 15, 2019. http://hdl.handle.net/2027.42/64627.

MLA Handbook (7th Edition):

Lee, Adam C. “SMARTS Approach to Chemical Data Mining and Physicochemical Property Prediction.” 2009. Web. 15 Jan 2019.

Vancouver:

Lee AC. SMARTS Approach to Chemical Data Mining and Physicochemical Property Prediction. [Internet] [Doctoral dissertation]. University of Michigan; 2009. [cited 2019 Jan 15]. Available from: http://hdl.handle.net/2027.42/64627.

Council of Science Editors:

Lee AC. SMARTS Approach to Chemical Data Mining and Physicochemical Property Prediction. [Doctoral Dissertation]. University of Michigan; 2009. Available from: http://hdl.handle.net/2027.42/64627


University of Michigan

6. Peng, Yuefeng. Design, Synthesis and Biological Evaluation of Non-Peptidic Small Molecular SMAC Mimetics as Potent IAP Inhibitors.

Degree: PhD, Medicinal Chemistry, 2008, University of Michigan

 The resistance of tumor cells to apoptosis is a major problem in current cancer therapies. Successful anticancer strategies would benefit from specific targeting of the… (more)

Subjects/Keywords: Smac; XIAP; C-IAP1; C-IAP2; Apoptosis; Cancer; Chemistry; Oncology and Hematology; Pharmacy and Pharmacology; Science (General); Health Sciences; Science

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APA (6th Edition):

Peng, Y. (2008). Design, Synthesis and Biological Evaluation of Non-Peptidic Small Molecular SMAC Mimetics as Potent IAP Inhibitors. (Doctoral Dissertation). University of Michigan. Retrieved from http://hdl.handle.net/2027.42/61591

Chicago Manual of Style (16th Edition):

Peng, Yuefeng. “Design, Synthesis and Biological Evaluation of Non-Peptidic Small Molecular SMAC Mimetics as Potent IAP Inhibitors.” 2008. Doctoral Dissertation, University of Michigan. Accessed January 15, 2019. http://hdl.handle.net/2027.42/61591.

MLA Handbook (7th Edition):

Peng, Yuefeng. “Design, Synthesis and Biological Evaluation of Non-Peptidic Small Molecular SMAC Mimetics as Potent IAP Inhibitors.” 2008. Web. 15 Jan 2019.

Vancouver:

Peng Y. Design, Synthesis and Biological Evaluation of Non-Peptidic Small Molecular SMAC Mimetics as Potent IAP Inhibitors. [Internet] [Doctoral dissertation]. University of Michigan; 2008. [cited 2019 Jan 15]. Available from: http://hdl.handle.net/2027.42/61591.

Council of Science Editors:

Peng Y. Design, Synthesis and Biological Evaluation of Non-Peptidic Small Molecular SMAC Mimetics as Potent IAP Inhibitors. [Doctoral Dissertation]. University of Michigan; 2008. Available from: http://hdl.handle.net/2027.42/61591

7. Anand, Jessica P. The Mu and Delta Opioid Receptors: Mixed Efficacy Ligands and Receptor Trafficking.

Degree: PhD, Medicinal Chemistry, 2013, University of Michigan

 Opioids are widely used in the treatment of pain; however, the development of tolerance and dependence limit clinical use. The co-administration of a µ opioid… (more)

Subjects/Keywords: Interactions of Mu and Delta Opioid Receptors; Biological Chemistry; Pharmacy and Pharmacology; Science (General); Health Sciences; Science

…system. Life Sciences, 2006. 79: p. 674-685. Ling, G.S.F., et al., Differential Development of… …Release in a Morphin Infusion Model. Life Sciences, 1989. 45: p. 1627-1636. Jutkiewicz, E.M… …Life Sciences, 2010. 86(1516): p. 598-603. George, S.R., et al., Oligomerization of… …Opioid Receptor Desensitization and Morphine Tolerance? Trends in Pharmacological Sciences… …Receptor Subtypes and Cross-talk with Mu Receptors. Trends in Pharmacological Sciences, 1993. 14… 

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APA (6th Edition):

Anand, J. P. (2013). The Mu and Delta Opioid Receptors: Mixed Efficacy Ligands and Receptor Trafficking. (Doctoral Dissertation). University of Michigan. Retrieved from http://hdl.handle.net/2027.42/102338

Chicago Manual of Style (16th Edition):

Anand, Jessica P. “The Mu and Delta Opioid Receptors: Mixed Efficacy Ligands and Receptor Trafficking.” 2013. Doctoral Dissertation, University of Michigan. Accessed January 15, 2019. http://hdl.handle.net/2027.42/102338.

MLA Handbook (7th Edition):

Anand, Jessica P. “The Mu and Delta Opioid Receptors: Mixed Efficacy Ligands and Receptor Trafficking.” 2013. Web. 15 Jan 2019.

Vancouver:

Anand JP. The Mu and Delta Opioid Receptors: Mixed Efficacy Ligands and Receptor Trafficking. [Internet] [Doctoral dissertation]. University of Michigan; 2013. [cited 2019 Jan 15]. Available from: http://hdl.handle.net/2027.42/102338.

Council of Science Editors:

Anand JP. The Mu and Delta Opioid Receptors: Mixed Efficacy Ligands and Receptor Trafficking. [Doctoral Dissertation]. University of Michigan; 2013. Available from: http://hdl.handle.net/2027.42/102338

8. Barraza, Scott. Development of Novel Small Molecule Inhibitors of Neurotropic Alphavirus Replication.

Degree: PhD, Medicinal Chemistry, 2014, University of Michigan

 Emerging mosquito-borne viruses (arboviruses) constitute a large public health risk because of the ubiquity of mosquitoes and the potential for mosquito-human transmission. Neurotropic alphaviruses are… (more)

Subjects/Keywords: Medicinal Chemistry; Drug Development; Organic Synthesis; Antiviral; Central Nervous System; Neurotropic Alphavirus; Pharmacy and Pharmacology; Chemistry; Science (General); Health Sciences; Science

…Introduction Arboviruses: An Emerging Public Health Threat New and emerging viruses pose an immense… …public health risk to the world population,1, 2 due in large part to a lack of effective… …vaccines and treatments, although inadequate public health responses may also play a significant… …alphavirus may interfere with vaccination against other alphaviruses.37-39 From a public health… …Chapter III). A general feature of these analogs was the replacement of the right-hand… 

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APA (6th Edition):

Barraza, S. (2014). Development of Novel Small Molecule Inhibitors of Neurotropic Alphavirus Replication. (Doctoral Dissertation). University of Michigan. Retrieved from http://hdl.handle.net/2027.42/110325

Chicago Manual of Style (16th Edition):

Barraza, Scott. “Development of Novel Small Molecule Inhibitors of Neurotropic Alphavirus Replication.” 2014. Doctoral Dissertation, University of Michigan. Accessed January 15, 2019. http://hdl.handle.net/2027.42/110325.

MLA Handbook (7th Edition):

Barraza, Scott. “Development of Novel Small Molecule Inhibitors of Neurotropic Alphavirus Replication.” 2014. Web. 15 Jan 2019.

Vancouver:

Barraza S. Development of Novel Small Molecule Inhibitors of Neurotropic Alphavirus Replication. [Internet] [Doctoral dissertation]. University of Michigan; 2014. [cited 2019 Jan 15]. Available from: http://hdl.handle.net/2027.42/110325.

Council of Science Editors:

Barraza S. Development of Novel Small Molecule Inhibitors of Neurotropic Alphavirus Replication. [Doctoral Dissertation]. University of Michigan; 2014. Available from: http://hdl.handle.net/2027.42/110325

9. Karatas, Hacer. Structure Based Design of Peptidomimetic Inhibitors of the MLL1-WDR5 Interaction.

Degree: PhD, Medicinal Chemistry, 2012, University of Michigan

 MLL1 is a histone-3 lysine-4 (H3K4) methyltransferase, which is misregulated in patients with leukemia and linked with tumorigenicity through upregulation of the target genes HoxA9… (more)

Subjects/Keywords: MLL1 Inhibitor; WDR5 Inhibitor; MLL1-WDR5 Interaction Inhibitor; MLL1 Mimetic; HoxA9; Histone 3 Lysine 4 Methylation; Chemistry; Science (General); Health Sciences; Science

…division.15,18 In general, post-translational histone modifications have diverse functions which… 

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APA (6th Edition):

Karatas, H. (2012). Structure Based Design of Peptidomimetic Inhibitors of the MLL1-WDR5 Interaction. (Doctoral Dissertation). University of Michigan. Retrieved from http://hdl.handle.net/2027.42/91605

Chicago Manual of Style (16th Edition):

Karatas, Hacer. “Structure Based Design of Peptidomimetic Inhibitors of the MLL1-WDR5 Interaction.” 2012. Doctoral Dissertation, University of Michigan. Accessed January 15, 2019. http://hdl.handle.net/2027.42/91605.

MLA Handbook (7th Edition):

Karatas, Hacer. “Structure Based Design of Peptidomimetic Inhibitors of the MLL1-WDR5 Interaction.” 2012. Web. 15 Jan 2019.

Vancouver:

Karatas H. Structure Based Design of Peptidomimetic Inhibitors of the MLL1-WDR5 Interaction. [Internet] [Doctoral dissertation]. University of Michigan; 2012. [cited 2019 Jan 15]. Available from: http://hdl.handle.net/2027.42/91605.

Council of Science Editors:

Karatas H. Structure Based Design of Peptidomimetic Inhibitors of the MLL1-WDR5 Interaction. [Doctoral Dissertation]. University of Michigan; 2012. Available from: http://hdl.handle.net/2027.42/91605

10. Ung, Man-Un. Incorporation of Protein Flexibility in Structure-Based Drug Discovery of HIV-1 Protease and Bacterial Hsp70 Chaperone.

Degree: PhD, Medicinal Chemistry, 2013, University of Michigan

 Damm et al. utilized a multiple protein structure (MPS)-based method and discovery an allosteric site of HIV-1 protease (HIV-1p) that had not been described before.… (more)

Subjects/Keywords: Medicinal Chemistry; Computational Chemistry; Protein Dynamics; Drug Discovery; HIV Protease; Heat Shock Protein 70 Hsp70 Chaperone; Biological Chemistry; Pharmacy and Pharmacology; Chemistry; Science (General); Health Sciences; Science

…shows the RMSD of compound 2 from its starting position in the Eye site. In general, compound… …RMSD of compound 2 to its starting position in the binding site. In general, compound 2 has… 

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APA (6th Edition):

Ung, M. (2013). Incorporation of Protein Flexibility in Structure-Based Drug Discovery of HIV-1 Protease and Bacterial Hsp70 Chaperone. (Doctoral Dissertation). University of Michigan. Retrieved from http://hdl.handle.net/2027.42/97785

Chicago Manual of Style (16th Edition):

Ung, Man-Un. “Incorporation of Protein Flexibility in Structure-Based Drug Discovery of HIV-1 Protease and Bacterial Hsp70 Chaperone.” 2013. Doctoral Dissertation, University of Michigan. Accessed January 15, 2019. http://hdl.handle.net/2027.42/97785.

MLA Handbook (7th Edition):

Ung, Man-Un. “Incorporation of Protein Flexibility in Structure-Based Drug Discovery of HIV-1 Protease and Bacterial Hsp70 Chaperone.” 2013. Web. 15 Jan 2019.

Vancouver:

Ung M. Incorporation of Protein Flexibility in Structure-Based Drug Discovery of HIV-1 Protease and Bacterial Hsp70 Chaperone. [Internet] [Doctoral dissertation]. University of Michigan; 2013. [cited 2019 Jan 15]. Available from: http://hdl.handle.net/2027.42/97785.

Council of Science Editors:

Ung M. Incorporation of Protein Flexibility in Structure-Based Drug Discovery of HIV-1 Protease and Bacterial Hsp70 Chaperone. [Doctoral Dissertation]. University of Michigan; 2013. Available from: http://hdl.handle.net/2027.42/97785

11. Kawamoto, Steven Akira. Targeting the BCL9/B9L Binding Interaction with B-catenin as a Potential Anticancer Strategy.

Degree: PhD, Medicinal Chemistry, 2010, University of Michigan

 Wnt signaling plays a critical role in numerous cellular processes including embryonic development, cell proliferation and tissue homeostasis. The multifunctional protein β-catenin is the primary… (more)

Subjects/Keywords: BCL9; BCL9 Inhibitors; Beta-catenin; Wnt Signaling; Cancer; Triazole Stapling; Biological Chemistry; Molecular, Cellular and Developmental Biology; Oncology and Hematology; Chemistry; Science (General); Health Sciences; Science

general, the initiators of the Wnt signaling pathways are the Wnt proteins themselves. To date… 

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APA (6th Edition):

Kawamoto, S. A. (2010). Targeting the BCL9/B9L Binding Interaction with B-catenin as a Potential Anticancer Strategy. (Doctoral Dissertation). University of Michigan. Retrieved from http://hdl.handle.net/2027.42/75846

Chicago Manual of Style (16th Edition):

Kawamoto, Steven Akira. “Targeting the BCL9/B9L Binding Interaction with B-catenin as a Potential Anticancer Strategy.” 2010. Doctoral Dissertation, University of Michigan. Accessed January 15, 2019. http://hdl.handle.net/2027.42/75846.

MLA Handbook (7th Edition):

Kawamoto, Steven Akira. “Targeting the BCL9/B9L Binding Interaction with B-catenin as a Potential Anticancer Strategy.” 2010. Web. 15 Jan 2019.

Vancouver:

Kawamoto SA. Targeting the BCL9/B9L Binding Interaction with B-catenin as a Potential Anticancer Strategy. [Internet] [Doctoral dissertation]. University of Michigan; 2010. [cited 2019 Jan 15]. Available from: http://hdl.handle.net/2027.42/75846.

Council of Science Editors:

Kawamoto SA. Targeting the BCL9/B9L Binding Interaction with B-catenin as a Potential Anticancer Strategy. [Doctoral Dissertation]. University of Michigan; 2010. Available from: http://hdl.handle.net/2027.42/75846


University of Michigan

12. Damm, Kelly Lynn. Protein Flexibility in Structure-Based Drug Design: Method Development and Novel Mechanisms for Inhibiting HIV-1 Protease.

Degree: PhD, Medicinal Chemistry, 2007, University of Michigan

 Structure-based drug design (SBDD) has emerged as an important tool in drug discovery research. Traditionally, SBDD is based on a static crystal structure of the… (more)

Subjects/Keywords: Structure-based Drug Design; Protein Flexibility; Human Immunodeficiency Virus Type 1 Protease; Novel Inhibition Mechanism of HIV-1 Protease; Flap-recognition Pocket; Chemistry; Science (General); Health Sciences; Science

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APA (6th Edition):

Damm, K. L. (2007). Protein Flexibility in Structure-Based Drug Design: Method Development and Novel Mechanisms for Inhibiting HIV-1 Protease. (Doctoral Dissertation). University of Michigan. Retrieved from http://hdl.handle.net/2027.42/57666

Chicago Manual of Style (16th Edition):

Damm, Kelly Lynn. “Protein Flexibility in Structure-Based Drug Design: Method Development and Novel Mechanisms for Inhibiting HIV-1 Protease.” 2007. Doctoral Dissertation, University of Michigan. Accessed January 15, 2019. http://hdl.handle.net/2027.42/57666.

MLA Handbook (7th Edition):

Damm, Kelly Lynn. “Protein Flexibility in Structure-Based Drug Design: Method Development and Novel Mechanisms for Inhibiting HIV-1 Protease.” 2007. Web. 15 Jan 2019.

Vancouver:

Damm KL. Protein Flexibility in Structure-Based Drug Design: Method Development and Novel Mechanisms for Inhibiting HIV-1 Protease. [Internet] [Doctoral dissertation]. University of Michigan; 2007. [cited 2019 Jan 15]. Available from: http://hdl.handle.net/2027.42/57666.

Council of Science Editors:

Damm KL. Protein Flexibility in Structure-Based Drug Design: Method Development and Novel Mechanisms for Inhibiting HIV-1 Protease. [Doctoral Dissertation]. University of Michigan; 2007. Available from: http://hdl.handle.net/2027.42/57666

13. Yu, Jingyu. A Subcellular Compartmental Modeling Approach to Pulmonary Drug Development.

Degree: PhD, Medicinal Chemistry, 2011, University of Michigan

 Predicting and controlling the systemic and local pharmacokinetics of pulmonary medications in different regions of the lung is critical for optimizing the efficacy and safety… (more)

Subjects/Keywords: Pharmacokinetics of Inhaled Drugs; 1Cell PK Model; Lung PBPK Model; Modeling and Simulations; Dissolution-Absorption Model; Biomedical Engineering; Complementary and Alternative Medicine; Pharmacy and Pharmacology; Chemistry; Science (General); Health Sciences; Science

…LIST OF FIGURES Figure. 2.1. Diagram representing the general route of drug transport… …Figure 3.1. General methodology of hybrid PBPK model …...74 Figure 3.2. The relationship… …lung ….. ….......80 Figure 4.1. General methodology of hybrid PBPK model… …gap between the basic sciences and the clinical application of drugs. 1.4 The Systemic and… …ascent of pulmonary drug delivery. Journal of Pharmaceutical Sciences 2000, 89 (7)… 

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APA (6th Edition):

Yu, J. (2011). A Subcellular Compartmental Modeling Approach to Pulmonary Drug Development. (Doctoral Dissertation). University of Michigan. Retrieved from http://hdl.handle.net/2027.42/86542

Chicago Manual of Style (16th Edition):

Yu, Jingyu. “A Subcellular Compartmental Modeling Approach to Pulmonary Drug Development.” 2011. Doctoral Dissertation, University of Michigan. Accessed January 15, 2019. http://hdl.handle.net/2027.42/86542.

MLA Handbook (7th Edition):

Yu, Jingyu. “A Subcellular Compartmental Modeling Approach to Pulmonary Drug Development.” 2011. Web. 15 Jan 2019.

Vancouver:

Yu J. A Subcellular Compartmental Modeling Approach to Pulmonary Drug Development. [Internet] [Doctoral dissertation]. University of Michigan; 2011. [cited 2019 Jan 15]. Available from: http://hdl.handle.net/2027.42/86542.

Council of Science Editors:

Yu J. A Subcellular Compartmental Modeling Approach to Pulmonary Drug Development. [Doctoral Dissertation]. University of Michigan; 2011. Available from: http://hdl.handle.net/2027.42/86542

.