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You searched for subject:(Hair cell physiology). Showing records 1 – 3 of 3 total matches.

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UCLA

1. Choy, Kristel Rae Wing Yee. Cellular adaptations in vestibular epithelia of the Egyptian fruit bat.

Degree: Physiological Science, 2016, UCLA

Bats are highly agile animals by virtue of their flight and echolocation behaviors, and they are acknowledged to be “spatiotemporal integration specialists.” In order to avoid obstacles, scavenge food, and capture prey, bats must be able to navigate a three-dimensional space. In flight, bats must perform high speed navigation through obstacles using a blend of sensory modalities including vision and echolocation. While some bat species exhibit structural adaptations to their cochleae as an adaptation to the demands of echolocation, there is an absence architectural adaptation of the vestibular labyrinth that would accommodate the increased demands for high frequency head movement coding associated with agile movement. The present study tested the hypothesis that there may exist cellular adaptations within the vestibular epithelia consistent with increased capability for high fidelity head movement coding. This was accomplished using immunohistochemical analyses focusing primarily in the striolae of the utricles of Rousettus aegyptiacus and Mus musculus, regions bounded by the presence of calretinin (Calb2) positive calyces. Hair cell counts revealed increased proportions of type I hair cells (hair cells surrounded by calyces) in Rousettus when compared to Mus (72.6% � 3.5% and 57.2% � 2.7%, respectively, p<10-5). Additionally, Rousettus exhibits increases in the proportion of complex calyces in the striola when compared to Mus. Ocm, a calcium binding protein expressed in vestibular hair cells, is also observed to have expanded expression in Rousettus and Mus both in the striola as well as the extrastriolar regions. These novel findings indicate that vestibular epithelia of Rousettus exhibit cellular adaptations over Mus that are consistent with increases in head movement coding capability associated with agile movement in flight.

Subjects/Keywords: Physiology; Neurosciences; Biology; CALB2; hair cell; KCNQ4; OCM; Rousettus; utricle

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Choy, K. R. W. Y. (2016). Cellular adaptations in vestibular epithelia of the Egyptian fruit bat. (Thesis). UCLA. Retrieved from http://www.escholarship.org/uc/item/02811829

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Choy, Kristel Rae Wing Yee. “Cellular adaptations in vestibular epithelia of the Egyptian fruit bat.” 2016. Thesis, UCLA. Accessed December 08, 2019. http://www.escholarship.org/uc/item/02811829.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Choy, Kristel Rae Wing Yee. “Cellular adaptations in vestibular epithelia of the Egyptian fruit bat.” 2016. Web. 08 Dec 2019.

Vancouver:

Choy KRWY. Cellular adaptations in vestibular epithelia of the Egyptian fruit bat. [Internet] [Thesis]. UCLA; 2016. [cited 2019 Dec 08]. Available from: http://www.escholarship.org/uc/item/02811829.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Choy KRWY. Cellular adaptations in vestibular epithelia of the Egyptian fruit bat. [Thesis]. UCLA; 2016. Available from: http://www.escholarship.org/uc/item/02811829

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

2. Gerenton, Grégory. Mesures non invasives de l'activité electrophysiologique des cellules sensorielles et des neurones auditifs. Applications au diagnostic de pathologies de l'oreille interne. : Noninvasive measurements of the electrophysiological activity of sensory cells and auditory neurons. Applications to the diagnosis of diseases of the inner ear.

Degree: Docteur es, Sciences de la vie et de la sante, 2015, Clermont-Ferrand 1

Grâce à la miniaturisation de la technologie ainsi qu'a l'augmentation constante des capacités de calcul numérique, les méthodes objectives et les appareils de mesures de la physiologie auditive évoluent. C'est dans l'optique de créer de nouveaux outils diagnostics que la société Echodia a été créée en 2009. Celle-ci finance aujourd'hui mes recherches sous convention CIFRE.Les présents travaux proposent, dans une première partie, de présenter comment deux méthodes de mesures non invasives ont été mises en oeuvre pour être applicables au diagnostic de l'hydrops cochléaire. Les méthodes sont basées sur le fait que les réponses des cellules ciliées de la cochlée à des stimuli sonores dépendent de la position au repos de leur touffe de stéréocils. Or, l'hydrops cochléaire, l'une des principales caractéristiques de la maladie de Menière, est susceptible de venir perturber cet environnement. Une variation chimique ou mécanique de celui-ci peut ainsi être mise en évidence par différentes méthodes d'exploration objectives. La première est basée sur un enregistrement électrophysiologique. En étudiant le Potentiel de sommation (SP) de l'ÉlectroCochléoGraphie (ECochG), nous allons recueillir une image du tour basal de la cochlée. La deuxième méthode est basée sur un enregistrement acoustique dans le méat acoustique externe. En monitorant le déphasage des Produits de distorsion desoto-émissions acoustiques (DPOAE), nous allons enregistrer les réponses du tour apical de la cochlée.La deuxième partie est consacrée à une étude au cours de laquelle nous avons enregistré de manière concomitante le SP (basal) ainsi que le DPOAE (apical) chez 73 patients souffrant de vertiges de Menière, à proximité d'une attaque (n = 40) ou entre les attaques, sans symptômes cliniques (n = 33). Dans le cas des DPOAE, c'est la phase du produit de distorsion (PDA) à 2*f1-f2 qui a été étudiée en réponse à des sons stimulants de fréquence f1 = 1 kHz et f2 = 1,2 kHz. La puissance des deux fondamentaux a été fixée entre 70 et 75dB SPL en fonction du niveau du DPOAE. Le rapport entre SP et le Potentiel d’action global (AP) a, quant à lui, été mesuré de manière extra-tympanique en réponse à des clics de 95dB nHL. Ces deux mesures ont été effectuées plusieurs fois pendant un test de posture afin d'évaluer leur stabilité.Les limites normales de déphasage du DPOAE en réponse à la posture [-18 °, +38 °] ont été dépassées chez 75% des patients étant venus consulter à proximité d'une crise. Sur ces mêmes sujets, l'étude du ratio entre SP et AP a dépassé la valeur normale (<0,40) dans 60% des cas. De plus, chez les patients à proximité d'une crise de vertige, les deux types de mesures révèlent des fluctuations entre deux répétitions. Ces écarts mettent en évidence combien l'hydrops entrave le bon fonctionnement de la mécanique cochléaire. Le fait de constater des variations sur des échelles de temps aussi courtes pourrait expliquer la sensibilité imparfaite des tests diagnostics. En effet, les protocoles de mesure du SP ou des DPOAE nécessitent un moyennage des… Advisors/Committee Members: Avan, Paul (thesis director).

Subjects/Keywords: Électrocochléographie,; Oto-émissions acoustiques; Physiologie des cellules ciliées,; Hydrops cochléaire; Endocochlear hydrops; Electrocochleography,; Otoacoustic emission; Hair cell physiology; 617.51

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Gerenton, G. (2015). Mesures non invasives de l'activité electrophysiologique des cellules sensorielles et des neurones auditifs. Applications au diagnostic de pathologies de l'oreille interne. : Noninvasive measurements of the electrophysiological activity of sensory cells and auditory neurons. Applications to the diagnosis of diseases of the inner ear. (Doctoral Dissertation). Clermont-Ferrand 1. Retrieved from http://www.theses.fr/2015CLF1MM17

Chicago Manual of Style (16th Edition):

Gerenton, Grégory. “Mesures non invasives de l'activité electrophysiologique des cellules sensorielles et des neurones auditifs. Applications au diagnostic de pathologies de l'oreille interne. : Noninvasive measurements of the electrophysiological activity of sensory cells and auditory neurons. Applications to the diagnosis of diseases of the inner ear.” 2015. Doctoral Dissertation, Clermont-Ferrand 1. Accessed December 08, 2019. http://www.theses.fr/2015CLF1MM17.

MLA Handbook (7th Edition):

Gerenton, Grégory. “Mesures non invasives de l'activité electrophysiologique des cellules sensorielles et des neurones auditifs. Applications au diagnostic de pathologies de l'oreille interne. : Noninvasive measurements of the electrophysiological activity of sensory cells and auditory neurons. Applications to the diagnosis of diseases of the inner ear.” 2015. Web. 08 Dec 2019.

Vancouver:

Gerenton G. Mesures non invasives de l'activité electrophysiologique des cellules sensorielles et des neurones auditifs. Applications au diagnostic de pathologies de l'oreille interne. : Noninvasive measurements of the electrophysiological activity of sensory cells and auditory neurons. Applications to the diagnosis of diseases of the inner ear. [Internet] [Doctoral dissertation]. Clermont-Ferrand 1; 2015. [cited 2019 Dec 08]. Available from: http://www.theses.fr/2015CLF1MM17.

Council of Science Editors:

Gerenton G. Mesures non invasives de l'activité electrophysiologique des cellules sensorielles et des neurones auditifs. Applications au diagnostic de pathologies de l'oreille interne. : Noninvasive measurements of the electrophysiological activity of sensory cells and auditory neurons. Applications to the diagnosis of diseases of the inner ear. [Doctoral Dissertation]. Clermont-Ferrand 1; 2015. Available from: http://www.theses.fr/2015CLF1MM17


University of Kentucky

3. Hadi, Shadan. MYOSIN-XVA IS KEY MOLECULE IN ESTABLISHING THE ARCHITECTURE OF MECHANOSENSORY STEREOCILIA BUNDLES OF THE INNER EAR HAIR CELLS.

Degree: 2018, University of Kentucky

Development of hair cell stereocilia bundles involves three stages: elongation, thickening, and supernumerary stereocilia retraction. Although Myo-XVa is known to be essential for stereocilia elongation, its role in retraction/thickening remains unknown. We quantified stereocilia numbers/diameters in shaker-2 mice (Myo15sh2) that have deficiencies in “long” and “short” isoforms of myosin-XVa, and in mice lacking only the “long” myosin-XVa isoform (Myo15ΔN). Our data showed that myosin-XVa is largely not involved in the developmental retraction of supernumerary stereocilia. In normal development, the diameters of the first (tallest)/second row stereocilia within a bundle are equal and grow simultaneously. The diameter of the third row stereocilia increases together with that of taller stereocilia until P1-2 and then either decreases almost two-fold in inner hair cells (IHCs) or stays the same in outer hair cells (OHCs), resulting in a prominent diameter gradation in IHCs and less prominent in OHCs. Sh2 mutation abolishes this gradation in IHCs/OHCs. Stereocilia of all rows grow in diameters nearly equally in Myo15sh2/sh2 IHCs and OHCs. Conversely, ΔN mutation does not affect normal stereocilia diameter gradation until ~P8. Therefore, myosin-XVa “short” isoform is essential for developmental thinning of third row stereocilia, which causes diameter gradation within a hair bundle.

Subjects/Keywords: MYO-XVa; Auditory Hair Cells; Stereocilia Diameter Gradation; Postnatal Development; Shaker-2; Cell and Developmental Biology; Communication Sciences and Disorders; Medical Sciences; Medicine and Health Sciences; Physiology

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Hadi, S. (2018). MYOSIN-XVA IS KEY MOLECULE IN ESTABLISHING THE ARCHITECTURE OF MECHANOSENSORY STEREOCILIA BUNDLES OF THE INNER EAR HAIR CELLS. (Masters Thesis). University of Kentucky. Retrieved from https://uknowledge.uky.edu/medsci_etds/9

Chicago Manual of Style (16th Edition):

Hadi, Shadan. “MYOSIN-XVA IS KEY MOLECULE IN ESTABLISHING THE ARCHITECTURE OF MECHANOSENSORY STEREOCILIA BUNDLES OF THE INNER EAR HAIR CELLS.” 2018. Masters Thesis, University of Kentucky. Accessed December 08, 2019. https://uknowledge.uky.edu/medsci_etds/9.

MLA Handbook (7th Edition):

Hadi, Shadan. “MYOSIN-XVA IS KEY MOLECULE IN ESTABLISHING THE ARCHITECTURE OF MECHANOSENSORY STEREOCILIA BUNDLES OF THE INNER EAR HAIR CELLS.” 2018. Web. 08 Dec 2019.

Vancouver:

Hadi S. MYOSIN-XVA IS KEY MOLECULE IN ESTABLISHING THE ARCHITECTURE OF MECHANOSENSORY STEREOCILIA BUNDLES OF THE INNER EAR HAIR CELLS. [Internet] [Masters thesis]. University of Kentucky; 2018. [cited 2019 Dec 08]. Available from: https://uknowledge.uky.edu/medsci_etds/9.

Council of Science Editors:

Hadi S. MYOSIN-XVA IS KEY MOLECULE IN ESTABLISHING THE ARCHITECTURE OF MECHANOSENSORY STEREOCILIA BUNDLES OF THE INNER EAR HAIR CELLS. [Masters Thesis]. University of Kentucky; 2018. Available from: https://uknowledge.uky.edu/medsci_etds/9

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