subject:(HPV)

California State University – Sacramento

1. Atwal, Inderdeep Singh. Use of a small molecule inhibitor drug to treat human papillomavirus induced cancer.

Degree: MA, Biological Sciences, 2011, California State University – Sacramento

► Human Papillomavirus (HPV) afflicts millions of individuals throughout the world and is the most prevalent sexually transmitted disease in the United States. Several strains of… (more)

▼ Human Papillomavirus (HPV) afflicts millions of individuals throughout the world and is the most prevalent sexually transmitted disease in the United States. Several strains of HPV have been linked to the formation of cancer, manifesting itself in a variety of locations (e.g; the vulva/vaginal, penis, anus, head and neck). Current cancer treatments have been limited to three established methods: chemotherapy, radiation and surgery. Each of these treatments have significant issues and provide mixed results for patients. Recent developments in the use of computer molecular modeling and advancements in the knowledge of cancer pathways have opened numerous new avenues for cancer treatment. A team led by Dr. Shaomeng Wang at the University of Michigan, Ann Arbor have used crystalline structure studies of the MDM2-p53 interaction to synthesize a molecule that has a higher affinity to MDM2 than p53, thus when the molecule is introduced into the cell it outcompetes p53 for MDM2 binding sites which frees p53. The freed p53 is then able to act as a tumor suppressor. The development of specific inhibitors as a potential cancer treatment has great promise for the battle against cancer. These small molecule inhibitors would have the potential to be a highly effective and specific treatment of cancer lacking many of the drawbacks of current cancer treatments. The goal of this grant proposal is to use the promising approach utilized by Dr. Wang???s team to treat HPV induced cancer. The hypothesis of this proposed study is that a small molecule designed de novo using bioinformatics software will be able to bind to E7 protein derived from Human Papillomavirus, inhibiting E7 from binding to the cell cycle regulatory protein pRb, and thereby inhibiting cancerous growth caused by HPV. The specific aims of this study are to: I. Utilize structure data on the E7-pRb binding pocket to design small molecule inhibitor candidates using computer modeling software. II. Utilize a Competitive Fluorescence Binding Assay to identify candidate molecules with the ability to outcompete pRb for the E7 binding pocket. III. Utilize a Cell Permeability Assay to determine whether candidate molecules can enter cells. IV. Utilize HPV cell cultures to test the ability of the small molecule inhibitors to halt cancerogenesis in vitro. V. Evaluation of the effects of the small molecule inhibitors on HPV cells. The development of a small molecule inhibitor to block the binding of pRb and HPV protein E7 is a key step in the development of a successful non-invasive therapy for HPV induced cancer. The use of the AMBER software suite and performing the series of steps above to evaluate their effectiveness to prevent the E7-pRb complex and inhibiting cell proliferation will be a critical step towards developing a new drug to treat HPV-induced cancer. Advisors/Committee Members: Peavy, Thomas R..

Subjects/Keywords: HPV

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APA (6^th Edition):

Atwal, I. S. (2011). Use of a small molecule inhibitor drug to treat human papillomavirus induced cancer. (Masters Thesis). California State University – Sacramento. Retrieved from http://hdl.handle.net/10211.9/1103

Chicago Manual of Style (16^th Edition):

Atwal, Inderdeep Singh. “Use of a small molecule inhibitor drug to treat human papillomavirus induced cancer.” 2011. Masters Thesis, California State University – Sacramento. Accessed April 21, 2018. http://hdl.handle.net/10211.9/1103.

MLA Handbook (7^th Edition):

Atwal, Inderdeep Singh. “Use of a small molecule inhibitor drug to treat human papillomavirus induced cancer.” 2011. Web. 21 Apr 2018.

Vancouver:

Atwal IS. Use of a small molecule inhibitor drug to treat human papillomavirus induced cancer. [Internet] [Masters thesis]. California State University – Sacramento; 2011. [cited 2018 Apr 21]. Available from: http://hdl.handle.net/10211.9/1103.

Council of Science Editors:

Atwal IS. Use of a small molecule inhibitor drug to treat human papillomavirus induced cancer. [Masters Thesis]. California State University – Sacramento; 2011. Available from: http://hdl.handle.net/10211.9/1103

University of Manitoba

2. Javame, Ali. Mathematical assessment of the role of pap screening on HPV transmission dynamics.

Degree: Mathematics, 2015, University of Manitoba

URL: http://hdl.handle.net/1993/30166

► Human papillomavirus (HPV), a major sexually-transmitted disease, causes cervical cancer, in addition to numerous other cancers in females and males. This thesis uses mathematical modeling,… (more)

Subjects/Keywords: HPV

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APA (6^th Edition):

Javame, A. (2015). Mathematical assessment of the role of pap screening on HPV transmission dynamics. (Masters Thesis). University of Manitoba. Retrieved from http://hdl.handle.net/1993/30166

Chicago Manual of Style (16^th Edition):

Javame, Ali. “Mathematical assessment of the role of pap screening on HPV transmission dynamics.” 2015. Masters Thesis, University of Manitoba. Accessed April 21, 2018. http://hdl.handle.net/1993/30166.

MLA Handbook (7^th Edition):

Javame, Ali. “Mathematical assessment of the role of pap screening on HPV transmission dynamics.” 2015. Web. 21 Apr 2018.

Vancouver:

Javame A. Mathematical assessment of the role of pap screening on HPV transmission dynamics. [Internet] [Masters thesis]. University of Manitoba; 2015. [cited 2018 Apr 21]. Available from: http://hdl.handle.net/1993/30166.

Council of Science Editors:

Javame A. Mathematical assessment of the role of pap screening on HPV transmission dynamics. [Masters Thesis]. University of Manitoba; 2015. Available from: http://hdl.handle.net/1993/30166

University of Debrecen

3. Hudák, Anett. A humán papillómavírus kimutatás jelentősége a méhnyakrák diagnosztikájában .

Degree: DE – TEK – Természettudományi és Technológiai Kar – Biológiai és Ökológiai Intézet, 2011, University of Debrecen

URL: http://hdl.handle.net/2437/108530

A humán papillómavírus kimutatás jelentősége a méhnyakrák diagnosztikájában.Vizsgálatok az onkogének regulációjával kapcsolatban.Méhnyakrákszűrési módszereket tekinthetünk meg a dolgozatban. Advisors/Committee Members: Szalmás, Anita (advisor).

Subjects/Keywords: HPV; vírus

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APA (6^th Edition):

Hudák, A. (2011). A humán papillómavírus kimutatás jelentősége a méhnyakrák diagnosztikájában . (Thesis). University of Debrecen. Retrieved from http://hdl.handle.net/2437/108530

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Hudák, Anett. “A humán papillómavírus kimutatás jelentősége a méhnyakrák diagnosztikájában .” 2011. Thesis, University of Debrecen. Accessed April 21, 2018. http://hdl.handle.net/2437/108530.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Hudák, Anett. “A humán papillómavírus kimutatás jelentősége a méhnyakrák diagnosztikájában .” 2011. Web. 21 Apr 2018.

Vancouver:

Hudák A. A humán papillómavírus kimutatás jelentősége a méhnyakrák diagnosztikájában . [Internet] [Thesis]. University of Debrecen; 2011. [cited 2018 Apr 21]. Available from: http://hdl.handle.net/2437/108530.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Hudák A. A humán papillómavírus kimutatás jelentősége a méhnyakrák diagnosztikájában . [Thesis]. University of Debrecen; 2011. Available from: http://hdl.handle.net/2437/108530

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Debrecen

4. Biró, Györgyi. A STAT3 transzkripciós faktor aktivitásának vizsgálata méhnyakrák eredetű sejtvonalakban .

Degree: DE – TEK – Természettudományi és Technológiai Kar – Biológiai és Ökológiai Intézet, 2010, University of Debrecen

URL: http://hdl.handle.net/2437/95406

► A méhnyakrák a nők második leggyakoribb daganatos megbetegedése, Magyarországon is a vezető halálokok közé tartozik. A betegség legfontosabb etiológiai faktorainak a humán papilllomavírusokat (HPV) tartják,… (more)

▼ A méhnyakrák a nők második leggyakoribb daganatos megbetegedése, Magyarországon is a vezető halálokok közé tartozik. A betegség legfontosabb etiológiai faktorainak a humán papilllomavírusokat (HPV) tartják, amelyek a cervikális hámsejteket fertőzik meg. Az úgynevezett onkogén, vagy magas kockázatú csoportba tartozó („high-risk”) HPV típusok, mint a HPV-16 és HPV-18, okozta perzisztens fertőzés során a vírusok onkogénjei beépülhetnek a fertőzött sejt genomjába és transzformálhatják a sejtet (Franco et al., 1999). Ez a fertőzéseknek azonban csak kis hányadában következik be, a fertőzések többsége tünetmentes, ugyanis a vírusok okozta hámléziók kifejlődése megáll vagy a léziók spontán visszafejlődnek a dysplasia korai stádiumaiban. A vírusfertőzés és a malignus daganat kifejlődése között hosszú idő telik el, amely alatt bizonyos faktorok elősegíthetik a rosszindulatú folyamatok elindulását. A STAT3 transzkripciós faktornak jelentős szerepet tulajdonítanak a daganatok kialakulásában és fejlődésében. A STAT3 számos gén expresszióját képes befolyásolni, így kritikus szerepet játszik a karcinogenezis kialakításában a proliferáció, az angiogenezis, az invázió és a sejtciklus folyamataira hatva (Maritano et al., 2004). Többféle daganatos megbetegedés kapcsán igazolták, hogy a STAT3 konstitutívan aktív a malignus sejtekben, így a cervikális karcinogenezis különböző stádiumaiban már felvetették a megnövekedett STAT3 aktiváció szerepét (Zhou et al., 2009). Tanulmányaim során arra kerestem a választ, hogy a STAT3 transzkripciós faktor aktivációja kimutatható-e humán cervix carcinomából származó sejtvonalakból. Az általam vizsgált sejtvonalak eltérő mértékben tartalmaznak HPV-16 vagy HPV-18 genomot. A laphámsejtes carcinoma eredetű SiHa sejtvonal 1-2 kópia integrálódott HPV-16 genomot tartalmaz sejtenként, az epitheliális adenocarcinoma eredetű HeLa sejtvonalakban viszont HPV-18 szekvenciák fordulnak elő. A sejtenkénti kópiaszám valamivel magasabb, 10 kópia sejtenként, de ez meg sem közelíti a CaSki sejtek HPV-16 genom tartalmát. A cervix epidermoid carcinoma eredetű CaSki sejtvonal esetén nagyjából 600 kópia HPV-16 genom integrálódik sejtenként. A STAT3 mRNS expressziójának vizsgálatakor azt tapasztaltuk, hogy a fent említett keratinocita és cervix carcinoma sejtvonalakban a STAT3 gén alacsonyabb szinten expresszálódott, mint a kontroll THP-1 sejtvonalban, de a különbség nem volt szignifikáns. Továbbá a HPV szekvenciákat hordozó epitheliális sejtvonalak STAT3 mRNS expressziója sem tér el lényegesen a primer humán keratinocita sejtvonalban tapasztaltaktól (4. ábra). A STAT3 fehérje aktív, foszforilált formájának kimutatásához forbolészterrel makrofág irányba differenciáltatott és LPS-sel aktivált monocita eredetű THP-1 sejteket használtunk kontrollként (5. ábra). Az aktív STAT3 fehérje a sejtmagba transzlokálódik, így tudja befolyásolni számos gén promóteréhez kötődve azok expressziós aktivitását. Azt tapasztaltuk, hogy a cervix epidermoid carcinomából származó CaSki sejtvonalban, amely hozzávetőleg 600 kópia integrálódott… Advisors/Committee Members: Hevérné Szalmás, Anita (advisor).

Subjects/Keywords: STAT3; HPV

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Biró, G. (2010). A STAT3 transzkripciós faktor aktivitásának vizsgálata méhnyakrák eredetű sejtvonalakban . (Thesis). University of Debrecen. Retrieved from http://hdl.handle.net/2437/95406

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Biró, Györgyi. “A STAT3 transzkripciós faktor aktivitásának vizsgálata méhnyakrák eredetű sejtvonalakban .” 2010. Thesis, University of Debrecen. Accessed April 21, 2018. http://hdl.handle.net/2437/95406.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Biró, Györgyi. “A STAT3 transzkripciós faktor aktivitásának vizsgálata méhnyakrák eredetű sejtvonalakban .” 2010. Web. 21 Apr 2018.

Vancouver:

Biró G. A STAT3 transzkripciós faktor aktivitásának vizsgálata méhnyakrák eredetű sejtvonalakban . [Internet] [Thesis]. University of Debrecen; 2010. [cited 2018 Apr 21]. Available from: http://hdl.handle.net/2437/95406.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Biró G. A STAT3 transzkripciós faktor aktivitásának vizsgálata méhnyakrák eredetű sejtvonalakban . [Thesis]. University of Debrecen; 2010. Available from: http://hdl.handle.net/2437/95406

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Debrecen

5. Gál, Zsuzsa. HPV fertőzés, és vele összefüggésbe hozható betegségek ismerete a 17- 25 év közötti nők körében .

Degree: DE – Egészségügyi Kar, 2014, University of Debrecen

URL: http://hdl.handle.net/2437/189263

► A HPV infekciók következtében nagyszámban kialakult betegségek, azok, akár súlyos következményei indokolják a téma jelentőségét és aktualitását. A korán diagnosztizált HPV fertőzés és annak megfelelő… (more)

Subjects/Keywords: HPV; méhnyakrák

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APA (6^th Edition):

Gál, Z. (2014). HPV fertőzés, és vele összefüggésbe hozható betegségek ismerete a 17- 25 év közötti nők körében . (Thesis). University of Debrecen. Retrieved from http://hdl.handle.net/2437/189263

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Gál, Zsuzsa. “HPV fertőzés, és vele összefüggésbe hozható betegségek ismerete a 17- 25 év közötti nők körében .” 2014. Thesis, University of Debrecen. Accessed April 21, 2018. http://hdl.handle.net/2437/189263.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Gál, Zsuzsa. “HPV fertőzés, és vele összefüggésbe hozható betegségek ismerete a 17- 25 év közötti nők körében .” 2014. Web. 21 Apr 2018.

Vancouver:

Gál Z. HPV fertőzés, és vele összefüggésbe hozható betegségek ismerete a 17- 25 év közötti nők körében . [Internet] [Thesis]. University of Debrecen; 2014. [cited 2018 Apr 21]. Available from: http://hdl.handle.net/2437/189263.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Gál Z. HPV fertőzés, és vele összefüggésbe hozható betegségek ismerete a 17- 25 év közötti nők körében . [Thesis]. University of Debrecen; 2014. Available from: http://hdl.handle.net/2437/189263

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of New Mexico

6. Flores, Sonya Persia. The role of furin in human papillomavirus infection.

Degree: Biomedical Sciences Graduate Program, 2012, University of New Mexico

URL: http://digitalrepository.unm.edu/biom_etds/60

► Human papillomaviruses (HPVs) are the causative agent of cervical cancer and infect skin and mucosal membranes. Through wounding the virus establishes infection in the basal… (more)

▼ Human papillomaviruses (HPVs) are the causative agent of cervical cancer and infect skin and mucosal membranes. Through wounding the virus establishes infection in the basal layer of human keratinocytes and requires differentiating squamous epithelium to complete the viral life cycle. HPV virions contain two structural viral proteins: the major capsid protein L1 that self-assembles into capsid structures, and the minor capsid protein, L2, that is essential for infection. It is believed that HPV cellular entry occurs via receptor-mediated endocytosis and that the primary attachment factors used by the virus are heparan sulfonated proteoglycans (HSPGs). Most current HPV literature follows an entry model whereby L1 binds to HSPGs, causing a conformational change in the capsid, thus allowing access to a furin/proprotein convertase (PC) cleavage site on L2. Once L2 is furin-cleaved, the virus binds to a yet unknown secondary internalization receptor(s). There is, however, a body of experimental evidence that does not support this entry model. For example, L1-only virus like particles (VLPs) are able to enter cells with similar kinetics as L1/L2 VLPs and mutagenesis of the L2 furin cleavage site does not abrogate the virions ability to enter the cell. Furthermore, recent research in our laboratory indicates an alternative mechanism of HPV infection, whereby the virus binds to cell-anchored HSPGs that are normally in complex with a variety of ligands including growth factors (GF), cytokines, extracellular matrix (ECM) proteins, and proteinases. Ectodomain shedding of syndecan-1 and HSPG by matrix metalloproteinases (MMPs) allows the HPV-HSPG-GF complexes to become soluble and move to secondary GF receptors, thereby allowing the virus to gain access to the cell. While MMPs are known to activate many biological molecules, they themselves are activated by furin/PCs. Due to these new observations and the existence of experimental evidence that does not support the current model of HPV infection, we postulate that the function of furin has been misinterpreted. Our data suggest that a cellular component important for the infection process is also a target of furin/PC activity. Furthermore, we have found that multiple PC members play roles at different steps of HPV infection. Advisors/Committee Members: Ozbun, Michelle, Lidke, Diane, Kajon, Adriana.

Subjects/Keywords: HPV; Furin

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Flores, S. P. (2012). The role of furin in human papillomavirus infection. (Masters Thesis). University of New Mexico. Retrieved from http://digitalrepository.unm.edu/biom_etds/60

Chicago Manual of Style (16^th Edition):

Flores, Sonya Persia. “The role of furin in human papillomavirus infection.” 2012. Masters Thesis, University of New Mexico. Accessed April 21, 2018. http://digitalrepository.unm.edu/biom_etds/60.

MLA Handbook (7^th Edition):

Flores, Sonya Persia. “The role of furin in human papillomavirus infection.” 2012. Web. 21 Apr 2018.

Vancouver:

Flores SP. The role of furin in human papillomavirus infection. [Internet] [Masters thesis]. University of New Mexico; 2012. [cited 2018 Apr 21]. Available from: http://digitalrepository.unm.edu/biom_etds/60.

Council of Science Editors:

Flores SP. The role of furin in human papillomavirus infection. [Masters Thesis]. University of New Mexico; 2012. Available from: http://digitalrepository.unm.edu/biom_etds/60

University of Dundee

7. Shankar, Athiva. Epidemiological and molecular insights into Human Papillomavirus-related head and neck squamous cell carcinomas.

Degree: PhD, 2016, University of Dundee

URL: http://hdl.handle.net/10588/dfd76e62-d92e-4e51-90b3-dacd1f6e34b0

► Over the last decade, Scotland has witnessed a rising incidence in squamous cell carcinomas of the head and neck (HNSCC), a phenomenon thought to be… (more)

▼ Over the last decade, Scotland has witnessed a rising incidence in squamous cell carcinomas of the head and neck (HNSCC), a phenomenon thought to be linked to infection with high-risk Human Papillomavirus (HPV). HPV-associated HNSCC are a distinct disease presenting unique epidemiological, biological and clinical challenges. However, establishing HPV-related disease is impaired by non-standardised testing protocols and lack of a consensus on the efficacy of existing biomarkers such as p16. This is further complicated by the absence of additional biological markers and a dearth in our understanding of the molecular mechanisms underlying HPV-driven tumourigenesis. While HPV positivity is more commonly detected in the oropharynx, its prevalence and clinical impact in other head and neck subsites remains largely unexplored. The research presented in this thesis was undertaken to determine the prevalence of high-risk HPV in a heterogeneous cohort of 293 HNSCC patients from Tayside and to evaluate the validity of EBP50, a scaffolding protein involved in cell polarity which is targeted by high-risk HPV, as a potential marker for HPV-driven HNSCC. The p16 status of the patients in the cohort was already known and tissue specimens were genotyped for HPV using PCR. HPV infection, defined as p16 positivity and a positive HPV DNA status, was identified in 14% of the cohort. The majority (83%) of the HPV-positive tumours involved the oropharynx while the oral cavity, pharynx and the nasal cavity (17%) were involved to a much smaller extent. High-risk HPV type 16 was the most prevalent HPV type. Patients with HPV-positive tumours had significantly improved overall survival (OS) (2 year OS, 77% vs 57%) and recurrence free survival rates (RFS) (2 year RFS, 92% vs 77%) compared to patients with HPV-negative tumours. A positive tumour HPV status was found to be an independent prognostic indicator (HR 0.216; 95% CI 0.06 – 0.771) and so, given the high morbidity and debilitating physical and psychological problems associated with prevailing aggressive treatment regimens, it is imperative that this knowledge is harnessed to develop and improve treatment strategies. EBP50 expression was evaluated, by immunohistochemical analysis, first in normal oral mucosa and followed up in a smaller subset of 156 HNSCC patients from the main cohort. In the normal tissue EBP50 expression was predominantly membranous. In the tumour samples four distinct EBP50 expression patterns were observed and, of these, weak/ negligible cytoplasmic EBP50 expression showed a strong correlation, only marginally lower than p16 overexpression, with HPV DNA status and was observed largely in patients with tumours of the oropharynx and no history of smoking. Absence of EBP50 expression in the plasma membranes of tumour cells was a recurring pattern in a majority of the tumour samples. The scale of this study, comprising a Tayside cohort of unprecedented size, will undoubtedly contribute to the existing knowledge of HPV incidence in head and neck cancer in Scotland.…

Subjects/Keywords: HPV; EBP50

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Shankar, A. (2016). Epidemiological and molecular insights into Human Papillomavirus-related head and neck squamous cell carcinomas. (Doctoral Dissertation). University of Dundee. Retrieved from http://hdl.handle.net/10588/dfd76e62-d92e-4e51-90b3-dacd1f6e34b0

Chicago Manual of Style (16^th Edition):

Shankar, Athiva. “Epidemiological and molecular insights into Human Papillomavirus-related head and neck squamous cell carcinomas.” 2016. Doctoral Dissertation, University of Dundee. Accessed April 21, 2018. http://hdl.handle.net/10588/dfd76e62-d92e-4e51-90b3-dacd1f6e34b0.

MLA Handbook (7^th Edition):

Shankar, Athiva. “Epidemiological and molecular insights into Human Papillomavirus-related head and neck squamous cell carcinomas.” 2016. Web. 21 Apr 2018.

Vancouver:

Shankar A. Epidemiological and molecular insights into Human Papillomavirus-related head and neck squamous cell carcinomas. [Internet] [Doctoral dissertation]. University of Dundee; 2016. [cited 2018 Apr 21]. Available from: http://hdl.handle.net/10588/dfd76e62-d92e-4e51-90b3-dacd1f6e34b0.

Council of Science Editors:

Shankar A. Epidemiological and molecular insights into Human Papillomavirus-related head and neck squamous cell carcinomas. [Doctoral Dissertation]. University of Dundee; 2016. Available from: http://hdl.handle.net/10588/dfd76e62-d92e-4e51-90b3-dacd1f6e34b0

Aristotle University Of Thessaloniki (AUTH); Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης (ΑΠΘ)

8. Τογκαρίδου, Ελεονώρα. Επιδημιολογική μελέτη σχετικά με τον επιπολασμό του ιού των ανθρώπινων θηλωμάτων και την αποδοχή του εμβολιασμού από τον γυναικείο πληθυ...

Degree: 2012, Aristotle University Of Thessaloniki (AUTH); Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης (ΑΠΘ)

URL: http://hdl.handle.net/10442/hedi/28351

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The purpose of this study is to explore (1) the prevalence and type distribution of high-risk HPV types in a screening population across Greece, and… (more)

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The purpose of this study is to explore (1) the prevalence and type distribution of high-risk HPV types in a screening population across Greece, and (2) the intention of women to vaccinate themselves and their adolescent daughter or son against HPV. Data is obtained from the “Lysistrata Program”, a project that investigated knowledge, attitudes and beliefs of Greek women about the prevention of cervical cancer. The study included 5.379 women in Greece, between October 2005 and January 2011. Cervical samples were collected by physicians and nurses in hospitals and health centers across the country from 5.107 women attending for cervical cancer screening. High-risk HPV DNA was detected by using Hybrid Capture 2 (HC2) and Polymerase Chain Reaction (PCR). A structured questionnaire was used in 5.379 participants of the project, investigating the acceptability to HPV vaccination. Logistic regression analysis was performed with SPSS 17.0. 5,78% of women (295/5.107) tested positive in high-risk HPV types. The most common type was HPV16 (1,43% in the whole sample and 24,81% of the typed samples) followed by HPV types 31, 35, 53, 18, 51, 56, 58, 52, 39, 66, 45, 33, 59 and 68. The overall HPV-vaccine acceptability rate for the participants themselves was 81,1% (4.360/5.379), for participants’ daughters was 70,9% (3.813/5.379) and for participants’ sons was 68% (3.658/5.379). The acceptance rates decreased significantly after the vaccine became available, both for the women themselves and for their daughters or sons. In women declining vaccination, the reported reasons were self-perception of insufficient knowledge and fear of adverse effects. The overall prevalence of high-risk HPV types in Greece does not differ from the pooled results published for Southern Europe. HPV16 was the most common type found in our sample. Its prevalence is similar to that described for Southern Europe. HPV vaccine acceptability rates decreased significantly among participating women after the introduction of HPV vaccines in Greece, due to insufficient information and safety concerns.

Η μελέτη αυτή έχει ως κύριο σκοπό τον υπολογισμό του επιπολασμού του HPV στην Ελλάδα καθώς επίσης και την αποτύπωση της κατανομής των τύπων του ιού στον Ελλαδικό χώρο. Παράλληλα εξετάζει την προοπτική αποδοχής εμβολιασμού από τις Ελληνίδες κατά του HPV για τις ίδιες, την ανήλικη κόρη τους ή τον ανήλικο γιο τους. Η μελέτη αντλεί τα στοιχεία της από το πρόγραμμα «Λυσιστράτη», στο οποίο έλαβαν μέρος 5.379 γυναίκες από την Ελληνική Επικράτεια. Πρόκειται για μια προοπτική μελέτη αντιπροσωπευτικού δείγματος (cross-section) του ελληνικού γυναικείου πληθυσμού. Σε 5.107 συμμετέχουσες γυναίκες διενεργήθηκε από τον Οκτώβριο του 2005 έως τον Ιανουάριο του 2011, έλεγχος της ύπαρξης του ιικού γονιδιώματος (HPV DNA τεστ) στον τράχηλο της μήτρας. Η λήψη του κυτταρικού υλικού γινόταν από το ιατρικό ή νοσηλευτικό προσωπικό στα Αγροτικά Ιατρεία, Κέντρα Υγείας ή Νοσοκομεία της εκάστοτε περιοχής της Ελλάδας, όπου προσέρχονταν οι γυναίκες κατόπιν πρόσκλησης μέσω κοινοποίησης από τα μέσα…

Subjects/Keywords: HPV ιός; Επιπολασμός HPV; Αποδοχή HPV εμβολιασμού,; Αποτελεσματικότητα-ασφάλεια HPV εμβολίων; HPV λοίμωξη; HPV virus; HPV prevalence; HPV vaccines acceptability; HPV vaccines; Efficacy-safety; HPV infection

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APA (6^th Edition):

Τογκαρίδου, . �. (2012). Επιδημιολογική μελέτη σχετικά με τον επιπολασμό του ιού των ανθρώπινων θηλωμάτων και την αποδοχή του εμβολιασμού από τον γυναικείο πληθυ... (Thesis). Aristotle University Of Thessaloniki (AUTH); Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης (ΑΠΘ). Retrieved from http://hdl.handle.net/10442/hedi/28351

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Τογκαρίδου, Ελεονώρα. “Επιδημιολογική μελέτη σχετικά με τον επιπολασμό του ιού των ανθρώπινων θηλωμάτων και την αποδοχή του εμβολιασμού από τον γυναικείο πληθυ...” 2012. Thesis, Aristotle University Of Thessaloniki (AUTH); Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης (ΑΠΘ). Accessed April 21, 2018. http://hdl.handle.net/10442/hedi/28351.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Τογκαρίδου, Ελεονώρα. “Επιδημιολογική μελέτη σχετικά με τον επιπολασμό του ιού των ανθρώπινων θηλωμάτων και την αποδοχή του εμβολιασμού από τον γυναικείο πληθυ...” 2012. Web. 21 Apr 2018.

Vancouver:

Τογκαρίδου �. Επιδημιολογική μελέτη σχετικά με τον επιπολασμό του ιού των ανθρώπινων θηλωμάτων και την αποδοχή του εμβολιασμού από τον γυναικείο πληθυ... [Internet] [Thesis]. Aristotle University Of Thessaloniki (AUTH); Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης (ΑΠΘ); 2012. [cited 2018 Apr 21]. Available from: http://hdl.handle.net/10442/hedi/28351.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Τογκαρίδου �. Επιδημιολογική μελέτη σχετικά με τον επιπολασμό του ιού των ανθρώπινων θηλωμάτων και την αποδοχή του εμβολιασμού από τον γυναικείο πληθυ... [Thesis]. Aristotle University Of Thessaloniki (AUTH); Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης (ΑΠΘ); 2012. Available from: http://hdl.handle.net/10442/hedi/28351

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Aristotle University Of Thessaloniki (AUTH); Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης (ΑΠΘ)

9. Traianou, Athina. Επιδημιολογικός, κλινικός και μοριακός έλεγχος ανοσοκατεσταλμένων γυναικών που μολύνθηκαν από τον ιό των ανθρώπινων θηλωμάτων.

Degree: 2015, Aristotle University Of Thessaloniki (AUTH); Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης (ΑΠΘ)

URL: http://hdl.handle.net/10442/hedi/36668

► Nowadays, HPV (Human Papilloma Virus) infection is the most common disease among sexually transmitted diseases. At the same time, several studies have strongly implicated human… (more)

▼ Nowadays, HPV (Human Papilloma Virus) infection is the most common disease among sexually transmitted diseases. At the same time, several studies have strongly implicated human papillomavirus (HPV) infection as a causative factor in the development of cervical cancer. Using sensitive Polymerase Chain Reaction (PCR) techniques, HPV-DNA is detected in almost 100% of invasive cervical cancers.However, the evolution of HPV infection depends on the virus type (oncogenic or not), the life status (smoking habits, sexual habits) and most important the immune system of the individual ( which will allow the virus to penetrate and cause a disease). All these factors are important for carcinogenesis by either making the infection more persistent or attributing to its evolution to cervical cancer. The knowledge of acting of these factors is vital in order to be able to understand the virus from the infection to the development of cancer. As a matter of fact, genetic alterations are necessary to influence the development of cancer by epigenetic modifications related to it.In fact, the prevalence of the HPV virus, is different among immunosuppressed women. Indeed in this group the severity of HPV-associated cervical disease has been linked to increasing immunological impairment. Therefore, for these immunocompromised patients, knowing the risk for HPV infection as well as their regular follow up, along with the use of new biomarkers for the early diagnosis of the disease, are of utmost importance.Epigenetic mechanisms such as DNA methylation, have been implicated in the pathogenesis of cancer, as they modify the regulation of gene expression, the cell differentiation and the predisposed cell death. Unnormal expression of DNA Methyltransferases has been involved in carcinogenesis by provoking either DNA hypomethylation or hypermethylation of nonmethylated CpG islands. This is why it is of great importance to understand the function of these proteins, in order to evaluate their potential as cancer markers.This case-control study consists of two groups of Greek women, immunosuppressed (by renal transplantation) and not, in order to examine and compare their enviromental factors and their immunosuppression with the HPV infection of their genital area along with the expression of Methyltransferases DNMT3A and DNMT3B.50 specimens of cervical smears and 50 specimens of vulva smears from immunosuppressed women, along with 100 specimens of cervical smears and 100 specimens of vulva smears of healthy women, were analyzed. The collection of smears was done by using an endocervical brush and cells were placed in sterilized tubes (Eppendorf) and stored at 00C prepared for molecular analysis of DNA and RNA.DNA was used in the PCR in order to detect HPV and then recognise each specific HPV type. At the same time pap smears were collected from each patient.RNA was used in the PCR in order to detect the expression of methyltransferases DNMT3A και DNMT3B.Then, the 14 immunosuppressed women and the 20 healthy women who had cervical cytological…

Subjects/Keywords: Μεταμοσχευμένες με HPV; Transplanted women with HPV

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Traianou, A. (2015). Επιδημιολογικός, κλινικός και μοριακός έλεγχος ανοσοκατεσταλμένων γυναικών που μολύνθηκαν από τον ιό των ανθρώπινων θηλωμάτων. (Thesis). Aristotle University Of Thessaloniki (AUTH); Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης (ΑΠΘ). Retrieved from http://hdl.handle.net/10442/hedi/36668

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Traianou, Athina. “Επιδημιολογικός, κλινικός και μοριακός έλεγχος ανοσοκατεσταλμένων γυναικών που μολύνθηκαν από τον ιό των ανθρώπινων θηλωμάτων.” 2015. Thesis, Aristotle University Of Thessaloniki (AUTH); Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης (ΑΠΘ). Accessed April 21, 2018. http://hdl.handle.net/10442/hedi/36668.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Traianou, Athina. “Επιδημιολογικός, κλινικός και μοριακός έλεγχος ανοσοκατεσταλμένων γυναικών που μολύνθηκαν από τον ιό των ανθρώπινων θηλωμάτων.” 2015. Web. 21 Apr 2018.

Vancouver:

Traianou A. Επιδημιολογικός, κλινικός και μοριακός έλεγχος ανοσοκατεσταλμένων γυναικών που μολύνθηκαν από τον ιό των ανθρώπινων θηλωμάτων. [Internet] [Thesis]. Aristotle University Of Thessaloniki (AUTH); Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης (ΑΠΘ); 2015. [cited 2018 Apr 21]. Available from: http://hdl.handle.net/10442/hedi/36668.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Traianou A. Επιδημιολογικός, κλινικός και μοριακός έλεγχος ανοσοκατεσταλμένων γυναικών που μολύνθηκαν από τον ιό των ανθρώπινων θηλωμάτων. [Thesis]. Aristotle University Of Thessaloniki (AUTH); Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης (ΑΠΘ); 2015. Available from: http://hdl.handle.net/10442/hedi/36668

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Uppsala University

10. Lundberg, Maria. Gymnasieelevers kunskap om och inställning till HPV och HPV-vaccin.

Degree: Public Health and Caring Sciences, 2014, Uppsala University

URL: http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-234188

► Bakgrund: Humant papillomvirus (HPV) är ett sexuellt överförbart vårtvirus, som kan orsaka cellförändringar och livmoderhalscancer. Tidigare forskning har visat att kunskap om HPV och… (more)

Subjects/Keywords: ungdomar; kunskap; attiyder; HPV; HPV-vaccin

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APA (6^th Edition):

Lundberg, M. (2014). Gymnasieelevers kunskap om och inställning till HPV och HPV-vaccin. (Thesis). Uppsala University. Retrieved from http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-234188

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Lundberg, Maria. “Gymnasieelevers kunskap om och inställning till HPV och HPV-vaccin.” 2014. Thesis, Uppsala University. Accessed April 21, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-234188.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Lundberg, Maria. “Gymnasieelevers kunskap om och inställning till HPV och HPV-vaccin.” 2014. Web. 21 Apr 2018.

Vancouver:

Lundberg M. Gymnasieelevers kunskap om och inställning till HPV och HPV-vaccin. [Internet] [Thesis]. Uppsala University; 2014. [cited 2018 Apr 21]. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-234188.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Lundberg M. Gymnasieelevers kunskap om och inställning till HPV och HPV-vaccin. [Thesis]. Uppsala University; 2014. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-234188

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

11. Geetha, B. Epidemiology of cervical cancer and antigenotoxic activity of green tea on cervical cancer cells;.

Degree: 2015, Avinashilingam Deemed University For Women

URL: http://shodhganga.inflibnet.ac.in/handle/10603/36870

►

Cancer of the cervix is the commonest genital tract malignancy in the newlinefemale and it has been ranked second to breast cancer About half a… (more)

Subjects/Keywords: Paptest; HPV; Antioxidants

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APA (6^th Edition):

Geetha, B. (2015). Epidemiology of cervical cancer and antigenotoxic activity of green tea on cervical cancer cells;. (Thesis). Avinashilingam Deemed University For Women. Retrieved from http://shodhganga.inflibnet.ac.in/handle/10603/36870

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Geetha, B. “Epidemiology of cervical cancer and antigenotoxic activity of green tea on cervical cancer cells;.” 2015. Thesis, Avinashilingam Deemed University For Women. Accessed April 21, 2018. http://shodhganga.inflibnet.ac.in/handle/10603/36870.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Geetha, B. “Epidemiology of cervical cancer and antigenotoxic activity of green tea on cervical cancer cells;.” 2015. Web. 21 Apr 2018.

Vancouver:

Geetha B. Epidemiology of cervical cancer and antigenotoxic activity of green tea on cervical cancer cells;. [Internet] [Thesis]. Avinashilingam Deemed University For Women; 2015. [cited 2018 Apr 21]. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/36870.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Geetha B. Epidemiology of cervical cancer and antigenotoxic activity of green tea on cervical cancer cells;. [Thesis]. Avinashilingam Deemed University For Women; 2015. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/36870

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Georgia State University

12. Vashist, Aastha. Genetic Differentiation of oral and oropharyngeal carcinoma based on Human Papillomavirus Status and Race.

Degree: MPH, Public Health, 2016, Georgia State University

URL: https://scholarworks.gsu.edu/iph_theses/500

► INTRODUCTION: Head and neck cancer is one of the most common malignancy in the world. While it has been associated with several factors like… (more)

Subjects/Keywords: HPV; genetic differentiation; Head and neck cancer; HPV active; HPV inactive; HPV negative

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APA (6^th Edition):

Vashist, A. (2016). Genetic Differentiation of oral and oropharyngeal carcinoma based on Human Papillomavirus Status and Race. (Thesis). Georgia State University. Retrieved from https://scholarworks.gsu.edu/iph_theses/500

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Vashist, Aastha. “Genetic Differentiation of oral and oropharyngeal carcinoma based on Human Papillomavirus Status and Race.” 2016. Thesis, Georgia State University. Accessed April 21, 2018. https://scholarworks.gsu.edu/iph_theses/500.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Vashist, Aastha. “Genetic Differentiation of oral and oropharyngeal carcinoma based on Human Papillomavirus Status and Race.” 2016. Web. 21 Apr 2018.

Vancouver:

Vashist A. Genetic Differentiation of oral and oropharyngeal carcinoma based on Human Papillomavirus Status and Race. [Internet] [Thesis]. Georgia State University; 2016. [cited 2018 Apr 21]. Available from: https://scholarworks.gsu.edu/iph_theses/500.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Vashist A. Genetic Differentiation of oral and oropharyngeal carcinoma based on Human Papillomavirus Status and Race. [Thesis]. Georgia State University; 2016. Available from: https://scholarworks.gsu.edu/iph_theses/500

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Queens University

13. Remes, Olivia. Determinants of non-uptake of the quadrivalent HPV vaccine; The Ontario Grade 8 HPV Vaccine Cohort Study .

Degree: Community Health & Epidemiology, 2013, Queens University

URL: http://hdl.handle.net/1974/7801

► Background: In 2007, the Canadian federal budget provided $300 million over three years to the provinces and territories to implement publicly-funded HPV immunization programs. Current… (more)

▼ Background: In 2007, the Canadian federal budget provided $300 million over three years to the provinces and territories to implement publicly-funded HPV immunization programs. Current estimates indicate that HPV vaccine uptake varies significantly across Canada and is reported to be lowest in Ontario at 53%. There is a paucity of literature on the determinants of HPV vaccine uptake in the Canadian context, therefore further research is needed. Objectives: To describe the patterns of HPV vaccine non-uptake across health units in Ontario, and identify the individual- and health unit (ecologic)-level factors that influenced HPV immunization decision-making between 2007 and 2011. Methods: The study linked administrative health and immunization databases to identify a retrospective population-based cohort of 144,047 girls eligible for Ontario's school-based HPV immunization program between 2007 and 2011. In this study a girl was considered vaccinated if she received at least 1 dose, otherwise she was considered unvaccinated. Ecologic or health unit-level factors that may have influenced HPV vaccine decision-making were assessed, as well as individual-level predictors including clinical characteristics and sociodemographics. A population-average model based on generalized estimating equations was used to identify determinants associated with non-uptake. Results: In all, 49.3% of girls from 21 public health units refused HPV immunization between 2007 and 2011. Non-uptake varied across health units, from 41.82% to 60.30%. In multivariate analyses, non-uptake was strongly associated with a history of autism (OR=1.60; 95% CI 1.34, 1.90) and Down's syndrome (OR=1.37; 95% CI 1.16, 1.63), refusal of mandatory and optional vaccines (OR=2.23; 95% CI 2.07, 2.4, and OR=3.96; 95% CI 3.87, 4.05, respectively), and infrequent physician visits (OR=1.45; 95% CI 1.35, 1.55). Contextual or health unit-level characteristics appeared to have a weak influence on vaccine decision-making. Conclusions: HPV immunization could lead to a lower risk of developing and dying from HPV-related cancers; however, non-uptake of this vaccine is high. Concerted efforts are needed to reduce missed opportunities during medical consultations, to refine communication strategies and activities to address the information needs of special groups, as well as to develop cross-sectoral collaborations to support the delivery of publicly-funded HPV immunization to schools across Canada.

Subjects/Keywords: HPV; Human papillomavirus

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Remes, O. (2013). Determinants of non-uptake of the quadrivalent HPV vaccine; The Ontario Grade 8 HPV Vaccine Cohort Study . (Thesis). Queens University. Retrieved from http://hdl.handle.net/1974/7801

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Remes, Olivia. “Determinants of non-uptake of the quadrivalent HPV vaccine; The Ontario Grade 8 HPV Vaccine Cohort Study .” 2013. Thesis, Queens University. Accessed April 21, 2018. http://hdl.handle.net/1974/7801.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Remes, Olivia. “Determinants of non-uptake of the quadrivalent HPV vaccine; The Ontario Grade 8 HPV Vaccine Cohort Study .” 2013. Web. 21 Apr 2018.

Vancouver:

Remes O. Determinants of non-uptake of the quadrivalent HPV vaccine; The Ontario Grade 8 HPV Vaccine Cohort Study . [Internet] [Thesis]. Queens University; 2013. [cited 2018 Apr 21]. Available from: http://hdl.handle.net/1974/7801.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Remes O. Determinants of non-uptake of the quadrivalent HPV vaccine; The Ontario Grade 8 HPV Vaccine Cohort Study . [Thesis]. Queens University; 2013. Available from: http://hdl.handle.net/1974/7801

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Debrecen

14. Torda, Tímea Angéla. Humán papillomavírus onkogének hatása a STAT3 transzkripciós faktor aktivitására keratinocitákban .

Degree: DE – TEK – Természettudományi és Technológiai Kar – Biológiai és Ökológiai Intézet, 2010, University of Debrecen

URL: http://hdl.handle.net/2437/95713

► Munkánk során a HPV E6 és E7 onkoproteinek hatását vizsgáltuk a STAT3 transzkripciós faktor aktivitására humán keratinocitákban RT-PCR és Western blot technikák alkalmazásával. Ereményeink azt… (more)

Subjects/Keywords: HPV; STAT3; papilloma

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APA (6^th Edition):

Torda, T. A. (2010). Humán papillomavírus onkogének hatása a STAT3 transzkripciós faktor aktivitására keratinocitákban . (Thesis). University of Debrecen. Retrieved from http://hdl.handle.net/2437/95713

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Torda, Tímea Angéla. “Humán papillomavírus onkogének hatása a STAT3 transzkripciós faktor aktivitására keratinocitákban .” 2010. Thesis, University of Debrecen. Accessed April 21, 2018. http://hdl.handle.net/2437/95713.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Torda, Tímea Angéla. “Humán papillomavírus onkogének hatása a STAT3 transzkripciós faktor aktivitására keratinocitákban .” 2010. Web. 21 Apr 2018.

Vancouver:

Torda TA. Humán papillomavírus onkogének hatása a STAT3 transzkripciós faktor aktivitására keratinocitákban . [Internet] [Thesis]. University of Debrecen; 2010. [cited 2018 Apr 21]. Available from: http://hdl.handle.net/2437/95713.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Torda TA. Humán papillomavírus onkogének hatása a STAT3 transzkripciós faktor aktivitására keratinocitákban . [Thesis]. University of Debrecen; 2010. Available from: http://hdl.handle.net/2437/95713

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

15. Pinto, Diogo Alves. Influência do HPV na saúde oral e a perspetiva da Medicina Dentária.

Degree: 2017, Universidade Fernando Pessoa

URL: https://www.rcaap.pt/detail.jsp?id=oai:bdigital.ufp.pt:10284/6468

►

A prevalência de HPV no cancro da orofaringe está a aumentar, contudo, cancros HPV positivos tm bom prognóstico, respondem bem à terapêutica e normalmente aparecem… (more)

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A prevalência de HPV no cancro da orofaringe está a aumentar, contudo, cancros HPV positivos tm bom prognóstico, respondem bem à terapêutica e normalmente aparecem em zonas como a base da língua, amígdalas e palato mole. É importante conhecer este vírus e quais as lesões benignas, pré-malignas e malignas que este pode induzir. Este vírus possui subtipos de alto ou de baixo risco e estão associados a lesões benignas ou malignas, sendo que o HPV 16 é o de maior perigo e as suas oncoproteínas uma das responsáveis pela transformação maligna das células do hospedeiro. Um maior conhecimento destas lesões e a sua distinção irá permitir um diagnóstico precoce, melhorando o prognóstico, assim como a educação para a saúde oral e promoção do auto exame devem ser prática corrente na consulta de medicina dentária. Das 60 referências pesquisadas, incluíndo livros, artigos e revistas, os critérios de inclusão utilizados na seleção dos artigos foram: publicações compreendidas entre o ano 2010 a 2017, artigos escritos em português e inglês e, de acordo com a pertinência e enquadramento da informação recolhida, foram efectivamente utilizados 42 referências nesta dissertação.

The prevalence of HPV in oropharyngeal cancer is increasing, however, HPV positive cancer has a good prognosis, respond well to therapy, and usually appear in areas such as the base of the tongue, tonsils, and soft palate. It is important to know this virus and what benign, pre-malignant and malignant lesions it can induce. This virus has high or low risk subtypes and is associated with benign or malignant lesions, with HPV 16 being the most dangerous and its oncoproteins one off the responsible for malignant transformation of host cells. Further knowledge of these lesions and their distinction will allow an early diagnosis, improving prognosis, as well as oral health education and self-examination promotion should be current practice in the dental clinic. From the 60 references surveyed, including books, articles and journals, the inclusion criteria used in the selection of articles were: publications between 2010 and 2017 e articles written in Portuguese and English. According to consultation and classification of the information collected, 42 references were actually used in this dissertation.

Advisors/Committee Members: Palmeira, Carlos.

Subjects/Keywords: HPV cancro oral; Epidemiologia do cancro oral e HPV; HPV proteinas oncogénicas; HPV lesões; HPV diagnóstico; HPV vacinação oral; HPV cancro cabeça e pescoço; HPV papel do dentista; HPV oral cancer; Epidemiology oral cancer and HPV; HPV oncogene proteins; HPV oral lesions; HPV diagnostic; HPV oral vaccination; HPV head and neck cancer; HPV dentist role; Domínio/Área Científica::Ciências Médicas::Medicina Clínica

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Pinto, D. A. (2017). Influência do HPV na saúde oral e a perspetiva da Medicina Dentária. (Thesis). Universidade Fernando Pessoa. Retrieved from https://www.rcaap.pt/detail.jsp?id=oai:bdigital.ufp.pt:10284/6468

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Pinto, Diogo Alves. “Influência do HPV na saúde oral e a perspetiva da Medicina Dentária.” 2017. Thesis, Universidade Fernando Pessoa. Accessed April 21, 2018. https://www.rcaap.pt/detail.jsp?id=oai:bdigital.ufp.pt:10284/6468.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Pinto, Diogo Alves. “Influência do HPV na saúde oral e a perspetiva da Medicina Dentária.” 2017. Web. 21 Apr 2018.

Vancouver:

Pinto DA. Influência do HPV na saúde oral e a perspetiva da Medicina Dentária. [Internet] [Thesis]. Universidade Fernando Pessoa; 2017. [cited 2018 Apr 21]. Available from: https://www.rcaap.pt/detail.jsp?id=oai:bdigital.ufp.pt:10284/6468.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Pinto DA. Influência do HPV na saúde oral e a perspetiva da Medicina Dentária. [Thesis]. Universidade Fernando Pessoa; 2017. Available from: https://www.rcaap.pt/detail.jsp?id=oai:bdigital.ufp.pt:10284/6468

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of New South Wales

16. Lee, Joyce Hang Kiu. Presence of human papillomavirus in human prostate.

Degree: Biotechnology & Biomolecular Sciences, 2013, University of New South Wales

URL: http://handle.unsw.edu.au/1959.4/53477

► Background: Prostate cancer is the most commonly diagnosed cancer in Australian men. Recent literature suggests that chronic inflammation has an important role in the pathogenesis… (more)

▼ Background: Prostate cancer is the most commonly diagnosed cancer in Australian men. Recent literature suggests that chronic inflammation has an important role in the pathogenesis of prostate cancer, but the cause of inflammation remains elusive. Chronic inflammation may be due to infection and human papillomavirus (HPV) is one of the potential causative organisms. Previous studies on the relationship between high-risk HPV and prostate cancer were inconclusive. Most molecular studies utilised standard PCR to detect HPV sequences in DNA isolated from prostate cancer specimens. We aimed to utilise a more sensitive molecular amplification technique to detect the presence of HPV in DNA extracted from prostate specimens. In parallel, we aimed to demonstrate the presence of HPV in prostate specimens and identify its cellular location by a non-amplification in situ technique. Methods: We performed real-time PCR using GP5+/6+* primers on DNA extracted from 72 paraffin-embedded formalin-fixed (FFPE) prostate specimens. Samples identified as potentially HPV positive were confirmed by sequencing. Chromogenic in situ hybridisation (CISH) was optimised on cervical cancer cell lines and FFPE cervical cancer specimens, and then applied to HVP screening on the same prostate specimens. Results: High-risk HPV was identified in a proportion of prostate specimens. HPV was detected in 6/36 normal/benign prostate specimens and 4/36 prostate cancer specimens. All positive samples except one genotyped to HPV18. CISH was successfully established in cervical cancer cell lines and FFPE cervical cancer specimens. One benign prostate specimen and one prostate cancer specimen were HPV positive by CISH. Due to significant background signals, HPV status could not be determined on a large number of prostate specimens. Conclusion: The real-time PCR result presented in this thesis demonstrated the presence of high risk HPV in some prostate specimens. Further study is required to determine whether HPV is biologically active in these cases. Real-time PCR followed by an in situ technique can be an effective strategy for HPV screening on FFPE specimens. Advisors/Committee Members: Whitaker, Noel , Biotechnology & Biomolecular Sciences, Faculty of Science, UNSW.

Subjects/Keywords: Human papillomavirus; HPV

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Lee, J. H. K. (2013). Presence of human papillomavirus in human prostate. (Masters Thesis). University of New South Wales. Retrieved from http://handle.unsw.edu.au/1959.4/53477

Chicago Manual of Style (16^th Edition):

Lee, Joyce Hang Kiu. “Presence of human papillomavirus in human prostate.” 2013. Masters Thesis, University of New South Wales. Accessed April 21, 2018. http://handle.unsw.edu.au/1959.4/53477.

MLA Handbook (7^th Edition):

Lee, Joyce Hang Kiu. “Presence of human papillomavirus in human prostate.” 2013. Web. 21 Apr 2018.

Vancouver:

Lee JHK. Presence of human papillomavirus in human prostate. [Internet] [Masters thesis]. University of New South Wales; 2013. [cited 2018 Apr 21]. Available from: http://handle.unsw.edu.au/1959.4/53477.

Council of Science Editors:

Lee JHK. Presence of human papillomavirus in human prostate. [Masters Thesis]. University of New South Wales; 2013. Available from: http://handle.unsw.edu.au/1959.4/53477

Aristotle University Of Thessaloniki (AUTH); Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης (ΑΠΘ)

17. Koutsos, Ioannis. Συσχέτιση των κυτταροκινών της τραχηλικής βλέννης με την λοίμωξη του τραχήλου της μήτρας από τους ιούς hpv.

Degree: 2014, Aristotle University Of Thessaloniki (AUTH); Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης (ΑΠΘ)

URL: http://hdl.handle.net/10442/hedi/34565

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Human Papilloma Viruses, known as HPV constitute a large group of viruses, which infect the skin and mucous membranes of human body. 40 of them… (more)

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Human Papilloma Viruses, known as HPV constitute a large group of viruses, which infect the skin and mucous membranes of human body. 40 of them affect the epithelium of the lower genital tract of women and the anogenital epithelium. The local immune response to infection by HPV consists principally in the stimulation and production of cellular immunity factors, such as the activated CD4+ and CD8+ T-lymphocytes, which produce a variety of cytokines. Those cytokines interact with each other, stimulating or suppressing the production of one another. Purpose: The purpose of this research was to investigate the relationship between locally secreted cytokines by the cervical epithelium, due to infection by HPV viruses, and cervical intraepithelial lesions. The lesions were either low-grade (LG-SIL), or high-grade (HG-SIL). The studied cytokines were the Interleukins IL-1α, IL-1β, IL-2, IL-4, IL-5, IL-6, IL-8, IL-10 and IL-12, the Tumor Necrosis Factors TNF-α and TNF-β, and the Transformation Growth Factor TGF-β1. Material and method: The survey involved women who attended the outpatient clinic and the cervical pathology and colposkopy unit of the 2nd Department of Obstetrics and Gynaecology of Aristotle University of Thessaloniki in Hippokration General Hospital of Thessaloniki for preventive control, and presenting for the first time an abnormal Pap smear. All these women underwent colposcopy and directed biopsy. Women in the study were classified into two categories, based on the result of the histological tissue examination. In the first category those with low-grade squamous intraepithelial lesion (LG-SIL) and in the second category those with high-grade squamous intraepithelial lesion (HG-SIL). The control group consisted of women with normal Papanicolaou smear. In addition, an HPV-DNA test was conducted using the method of polymerase chain reaction (PCR) to detect the presence of HPV into the cervical epithelial cells and proceed with the classification of the 35 clinically significant types, either low risk, or oncogenous. The measurement of cytokine levels took place using flow cytometry and the technique of microsphere-based immunoassay. Results-Conclusion: The levels of 9 of the 12 cytokines tested, were lower in LG-SIL women group, compared with the HG-SIL group. These cytokines are: IL-1α, IL-1β, IL-2, IL-4, IL-5, IL-8, IL-10, IL-12 and TNF–α. From these cytokines statistically significant difference emerged for IL-1α, IL-2, IL-4 and TNF-α. Levels of these cytokines in the environment of the uterine cervix appear to be associated with the persistent infection by HPV. As regards the group of negative women, five of the studied cytokines were not detected at all. This clearly indicates a direct correlation of these cytokines with the infection by HPV. It is about: IL-2, IL-6, IL-10, IL-12 and TGF-β. Also IL-4 and TNF-β were detected at very low levels.

Οι ιοί των ανθρωπίνων θηλωμάτων, γνωστοί διεθνώς και σαν HPV (Human Papilloma Viruses), αποτελούν μία μεγάλη ομάδα ιών, οι οποίοι προσβάλλουν το δέρμα και…

Subjects/Keywords: HPV; Λοίμωξη από τον HPV; Κυτταροκίνες; Τραχηλική βλέννη; Κυτταρομετρία ροής; Ανοσιακή απάντηση στον HPV; HPV; HPV infection; Cytokines; Cervical mucus; Flow cytometry; Immune response to HPV

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Koutsos, I. (2014). Συσχέτιση των κυτταροκινών της τραχηλικής βλέννης με την λοίμωξη του τραχήλου της μήτρας από τους ιούς hpv. (Thesis). Aristotle University Of Thessaloniki (AUTH); Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης (ΑΠΘ). Retrieved from http://hdl.handle.net/10442/hedi/34565

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Koutsos, Ioannis. “Συσχέτιση των κυτταροκινών της τραχηλικής βλέννης με την λοίμωξη του τραχήλου της μήτρας από τους ιούς hpv.” 2014. Thesis, Aristotle University Of Thessaloniki (AUTH); Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης (ΑΠΘ). Accessed April 21, 2018. http://hdl.handle.net/10442/hedi/34565.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Koutsos, Ioannis. “Συσχέτιση των κυτταροκινών της τραχηλικής βλέννης με την λοίμωξη του τραχήλου της μήτρας από τους ιούς hpv.” 2014. Web. 21 Apr 2018.

Vancouver:

Koutsos I. Συσχέτιση των κυτταροκινών της τραχηλικής βλέννης με την λοίμωξη του τραχήλου της μήτρας από τους ιούς hpv. [Internet] [Thesis]. Aristotle University Of Thessaloniki (AUTH); Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης (ΑΠΘ); 2014. [cited 2018 Apr 21]. Available from: http://hdl.handle.net/10442/hedi/34565.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Koutsos I. Συσχέτιση των κυτταροκινών της τραχηλικής βλέννης με την λοίμωξη του τραχήλου της μήτρας από τους ιούς hpv. [Thesis]. Aristotle University Of Thessaloniki (AUTH); Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης (ΑΠΘ); 2014. Available from: http://hdl.handle.net/10442/hedi/34565

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Vienna

18. Adametz, Katharina. Eine Auseinandersetzung zum Rezipientenverhalten bei Gesundheitswerbung in Theorie und Praxis.

Degree: 2008, University of Vienna

URL: http://othes.univie.ac.at/3308/

►

Ausgangspunkt dieser Arbeit bildet der vom Österreichischen Grünen Kreuz scheinbar zur Information und Aufklärung initiierte TV-Spot zur Impfung gegen HPV-Infektionen. Dieser wurde im Herbst 2007… (more)

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Ausgangspunkt dieser Arbeit bildet der vom Österreichischen Grünen Kreuz scheinbar zur Information und Aufklärung initiierte TV-Spot zur Impfung gegen HPV-Infektionen. Dieser wurde im Herbst 2007 im Österreichischen Rundunk ausgestrahlt. Humane Papillom Viren werden als Hauptverursacher von Gebärmutterhalskrebs angesehen, deren Übertragung im wesentlichen durch Geschlechtsverkehr erfolgt. Aus diesem Grund erscheint eine Aufklärung wichtig, die sich nicht nur an Frauen (respektive Mütter) richtet, sondern auch weitere davon betroffene Personengruppen anspricht. Die Impfung selbst ist zur Zeit für Kinder zwischen 9 und 15 Jahren, sowie für junge Frauen von 16 bis 26 Jahren zugelassen. Die Durchseuchung der Bevölkerung mit dem HP-Virus ist allerdings sehr hoch, zumal auch Männer unwissentlich zu Überträgern und auch direkt Betroffenen werden können. Daraus folgt, dass auch Männer über die Risiken einer Ansteckung mit HPV bescheid wissen sollten, um sich dahingehend schützen zu können. Das unzureichende Wissen über das HP-Virus, seine Übertragung und mögliche Konsequenzen ist mit ein Grund, weshalb eine diesbezügliche Prävention erschwert erscheint. Ziel der Arbeit ist es daher, mögliche Schwachstellen des TV-Spot aufzuzeigen, die seine Effektivität hinsichtlich Prävention und Aufklärung beeinträchtigen könnten. Für die empirische Untersuchung wurde das Gruppendiskussionsverfahren nach Ralf Bohnsack herangezogen. Die theoretische Auseinandersetzung dieser Arbeit beschäftigt sich mit der Definition des Gesundheitsbegriffs, wobei auch auf Gesundheitsbewusstsein, Gesundheitsförderung, Prävention und Theorien bzw. Modelle des Gesundheitsverhaltens eingegangen wird. Auch der Bereich der Gesundheitskommunikation in seinen Ausformungen und Ebenen wird überblicksmäßig umrissen. Des weiteren werden auch für die Themenstellung als relevant erachtete Modelle der Medienwirkungsforschung vorgestellt und die Methodologie des Gruppendiskussionsverfahren, wie es hier zur Anwendung kommt, näher beleuchtet. Das theoretische Fundament wurde zur Formulierung des Forschungsinteresses, sowie zur Ursachenerkundung unterstützend herangezogen.

This thesis deals with the tv-spot about HPV-vaccination and its effects regarding to recipients. The mentioned tv-commercial was broadcasted in autumn 2007 on the ORF (Austrian public broadcasting). The purpose of this study is to demonstrate whether elements of this tv-commercial are recognizable as influences that contribute to a possible rethinking regarding attitudes towards health, as well as the concern for health and health-minded lifestyle. Additionally, as the test persons watch the tv-spot and comment on it, their feelings and opinions are to be determined so the efficiency of the tv-commercial and its possible weaknesses can be exposed. As the scientific interest relates to individual impressions, applying a qualitative research seemed to be the most appropriate approach, as it provided the necessary flexibility and transparency. For this purpose the method of group discussion…

Subjects/Keywords: 05.20 Kommunikation und Gesellschaft; HPV-Infektionen / HPV-Impfung / HPV-Spot / Rezipientenverhalten / Gesundheitswerbung / Gruppendiskussion; HPV-infection / HPV-vaccination / HPV-commercial / health promotion / group discussion

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Adametz, K. (2008). Eine Auseinandersetzung zum Rezipientenverhalten bei Gesundheitswerbung in Theorie und Praxis. (Thesis). University of Vienna. Retrieved from http://othes.univie.ac.at/3308/

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Adametz, Katharina. “Eine Auseinandersetzung zum Rezipientenverhalten bei Gesundheitswerbung in Theorie und Praxis.” 2008. Thesis, University of Vienna. Accessed April 21, 2018. http://othes.univie.ac.at/3308/.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Adametz, Katharina. “Eine Auseinandersetzung zum Rezipientenverhalten bei Gesundheitswerbung in Theorie und Praxis.” 2008. Web. 21 Apr 2018.

Vancouver:

Adametz K. Eine Auseinandersetzung zum Rezipientenverhalten bei Gesundheitswerbung in Theorie und Praxis. [Internet] [Thesis]. University of Vienna; 2008. [cited 2018 Apr 21]. Available from: http://othes.univie.ac.at/3308/.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Adametz K. Eine Auseinandersetzung zum Rezipientenverhalten bei Gesundheitswerbung in Theorie und Praxis. [Thesis]. University of Vienna; 2008. Available from: http://othes.univie.ac.at/3308/

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

19. Correr, Wagner Rafael. Development of impedimetric DNA sensor for diagnosis of Human Papillomavirus type 18 infection.

Degree: Mestrado, Física Aplicada, 2014, University of São Paulo

URL: http://www.teses.usp.br/teses/disponiveis/76/76132/tde-05032015-144417/ ;

►

Currently, the most common strategy employed to detect DNA sequences is PCR (Polymerase Chain Reaction). Nevertheless, in the last few years research on DNA biosensors… (more)

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Currently, the most common strategy employed to detect DNA sequences is PCR (Polymerase Chain Reaction). Nevertheless, in the last few years research on DNA biosensors has increased significantly. Such sensors represent an alternative to PCR in the detection of specific DNA sequences, once they exhibit fast response, low limits of detection, and require simpler sample preparation. The development of a biosensor for detection of DNA from Human Papillomavirus type 18 is reported. To immobilise DNA probe onto indium-tin oxide (ITO) electrodes, a silanisation was carried out using 3-Aminopropyltryethoxysilane (APTES). Silanisation was studied and optimised using ultra-violet absorption spectroscopy, atomic force microscopy, fluorescence microscopy, and cyclic voltammetry. After immobilisation, the hybridisation with target sequence is detected by changes in surface properties of ITO electrode by Cyclic Voltammetry and Electrochemical Impedance Spectroscopy, using the Ferri-Ferrocyante redox couple. The detection of synthetic target sequence was performed in the range of 12.5 to 100 nM, and 300nM for PCR products. The sensor did not show significative response for non-complementary sequence at 50 nM. This sensor can be applied for fast and low cost detection of HPV genetic material at nanomolar levels.

A estratégia mais empregada atualmente na detecção de sequência de DNA é a PCR (Reação em Cadeira da Polimerase). Contudo, nos últimos anos, a pesquisa em biossensores de DNA tem aumentado significativamente. Estes sensores representam uma alternativa a PCR na detecção de sequências específicas de DNA, uma vez que exibem resposta rápida, baixos limites de detecção e requerem preparação simples da amostra. Nesta dissertação descrito o desenvolvimento de um biossensor para a detecção do DNA do Papilomavirus Humano tipo 18. A fim de imobilizar a sequência de captura de DNA em eletrodos de óxido de estanho e índio (ITO), realizou-se uma silanização usando 3-Aminopropiltrietoxisilano (APTES). A reação de silanização foi estudada e otimizada através das técnicas de Espectroscopia de Absorção Ultravioleta, Microscopia de Força Atômica, Microscopia de Fluorescência e Voltametria Cíclica. Após a imobilização, a hibridização com a sequência alvo é detectada através de alterações nas propriedades de superfície do eletrodo através de Voltametria Cíclica e Espectroscopia de Impedância Eletroquímica, usando o par redox Ferri-ferrocianeto. A detecção da sequência alvo sintética foi realizada no intervalo de 12.5 a 100 nM, e para o produto de PCR, 300 nM. O sensor não demonstrou resposta significativa para sequência não complementar a 50 nM. Este sensor pode ser aplicado na detecção rápida e de baixo custo de material genético do HPV a níveis nanomolares.

Advisors/Committee Members: Zucolotto, Valtencir.

Subjects/Keywords: Eletroquímica; HPV; Sensor de DNA

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Correr, W. R. (2014). Development of impedimetric DNA sensor for diagnosis of Human Papillomavirus type 18 infection. (Masters Thesis). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/76/76132/tde-05032015-144417/ ;

Chicago Manual of Style (16^th Edition):

Correr, Wagner Rafael. “Development of impedimetric DNA sensor for diagnosis of Human Papillomavirus type 18 infection.” 2014. Masters Thesis, University of São Paulo. Accessed April 21, 2018. http://www.teses.usp.br/teses/disponiveis/76/76132/tde-05032015-144417/ ;.

MLA Handbook (7^th Edition):

Correr, Wagner Rafael. “Development of impedimetric DNA sensor for diagnosis of Human Papillomavirus type 18 infection.” 2014. Web. 21 Apr 2018.

Vancouver:

Correr WR. Development of impedimetric DNA sensor for diagnosis of Human Papillomavirus type 18 infection. [Internet] [Masters thesis]. University of São Paulo; 2014. [cited 2018 Apr 21]. Available from: http://www.teses.usp.br/teses/disponiveis/76/76132/tde-05032015-144417/ ;.

Council of Science Editors:

Correr WR. Development of impedimetric DNA sensor for diagnosis of Human Papillomavirus type 18 infection. [Masters Thesis]. University of São Paulo; 2014. Available from: http://www.teses.usp.br/teses/disponiveis/76/76132/tde-05032015-144417/ ;

University of Sydney

20. Brotherton, Julia Mary Louise. Human papillomavirus vaccination in Australia: assessing coverage and developing surveillance strategies .

Degree: 2014, University of Sydney

URL: http://hdl.handle.net/2123/12112

► The research in this thesis by publication explores some key aspects of the implementation of the world’s first government funded human papillomavirus (HPV) vaccination program.… (more)

Subjects/Keywords: human papillomavirus; HPV; immunisation; vaccination

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Brotherton, J. M. L. (2014). Human papillomavirus vaccination in Australia: assessing coverage and developing surveillance strategies . (Thesis). University of Sydney. Retrieved from http://hdl.handle.net/2123/12112

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Brotherton, Julia Mary Louise. “Human papillomavirus vaccination in Australia: assessing coverage and developing surveillance strategies .” 2014. Thesis, University of Sydney. Accessed April 21, 2018. http://hdl.handle.net/2123/12112.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Brotherton, Julia Mary Louise. “Human papillomavirus vaccination in Australia: assessing coverage and developing surveillance strategies .” 2014. Web. 21 Apr 2018.

Vancouver:

Brotherton JML. Human papillomavirus vaccination in Australia: assessing coverage and developing surveillance strategies . [Internet] [Thesis]. University of Sydney; 2014. [cited 2018 Apr 21]. Available from: http://hdl.handle.net/2123/12112.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Brotherton JML. Human papillomavirus vaccination in Australia: assessing coverage and developing surveillance strategies . [Thesis]. University of Sydney; 2014. Available from: http://hdl.handle.net/2123/12112

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Tulane University

21. Pop, Cristina A. Challenging Reproductive Health Care Delivery In Post-socialist Romania: Corruption, Reproduction, And The State.

Degree: 2016, Tulane University

URL: https://digitallibrary.tulane.edu/islandora/object/tulane:58236

►

This dissertation is an ethnographic study of the corruption narratives surrounding the quest for and the delivery of reproductive health care in contemporary Romania. Using… (more)

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This dissertation is an ethnographic study of the corruption narratives surrounding the quest for and the delivery of reproductive health care in contemporary Romania. Using as case study two public health campaigns targeting cervical cancer through early detection (Papanicolaou testing) and prevention (Human Papilloma Virus vaccination), it explores the ways Romanian women imagine the newly liberalized state and define themselves as post-Socialist citizens. The recent reforms in the provision of medical care have highlighted once again reproduction as a site of contestation. In sharp contrast with the Socialist pro-natalist policies, we currently witness the state’s progressive withdrawal from regulating reproduction, paralleled with the privatization of significant segments of reproductive health care delivery and with the marketization of women’s health. The range of reproductive choices has multiplied, but the emergence of new standards of inclusion/exclusion has limited the access to adequate care for many Romanian women. My interlocutors’ multi-layered discourses of reproduction and corruption are intrinsically ideological, revealing a folded blaming: of the former Socialist state paternalism and of the present post-Socialist state failure. In this context of unprecedented socio-cultural transformation, personhood becomes situational, shifting back and forth from Romanian citizen (when blaming the state for failing to provide proper reproductive assistance), to private person (when resisting mandatory national reproductive care programs). If we aim to decipher women’s responses to the Pap testing and HPV vaccination campaigns, we need to go beyond the ethnographically documented understandings of ‘risk, ’prevention,’ and ‘early detection.’ In a place such as present-day Romania, where bribe-offering is the idiom through which patients and doctors communicate, reproductive health care constitutes a privileged locus for analyzing how corruption discursively tames unsettled medical landscapes. By gathering the corruption narratives surrounding reproductive health care delivery, this dissertation grasps the micro-political factors that shape women’s local interactions, but it also analyzes the impact of “small scale” findings at a national and transnational level. My anthropological account – of what appears in retrospect to be “the chronicle of a failure foretold” – would be a crucial tool for policy makers in their future attempts to implement successful reproductive health programs.

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Cristina A. Pop

Advisors/Committee Members: Masquelier, Adeline (Thesis advisor), School of Liberal Arts Anthropology (Degree granting institution).

Subjects/Keywords: Reproduction; HPV Vaccination; Romania

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APA (6^th Edition):

Pop, C. A. (2016). Challenging Reproductive Health Care Delivery In Post-socialist Romania: Corruption, Reproduction, And The State. (Thesis). Tulane University. Retrieved from https://digitallibrary.tulane.edu/islandora/object/tulane:58236

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Pop, Cristina A. “Challenging Reproductive Health Care Delivery In Post-socialist Romania: Corruption, Reproduction, And The State.” 2016. Thesis, Tulane University. Accessed April 21, 2018. https://digitallibrary.tulane.edu/islandora/object/tulane:58236.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Pop, Cristina A. “Challenging Reproductive Health Care Delivery In Post-socialist Romania: Corruption, Reproduction, And The State.” 2016. Web. 21 Apr 2018.

Vancouver:

Pop CA. Challenging Reproductive Health Care Delivery In Post-socialist Romania: Corruption, Reproduction, And The State. [Internet] [Thesis]. Tulane University; 2016. [cited 2018 Apr 21]. Available from: https://digitallibrary.tulane.edu/islandora/object/tulane:58236.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Pop CA. Challenging Reproductive Health Care Delivery In Post-socialist Romania: Corruption, Reproduction, And The State. [Thesis]. Tulane University; 2016. Available from: https://digitallibrary.tulane.edu/islandora/object/tulane:58236

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universidade de Brasília

22. Daniela Marreco Cerqueira. Prevalência, freqüência de genótipos e de variantes de Papilomavírus Humanos em mulheres co-infectadas com o vírus da Imunodeficiência Humana Tipo 1 no Distrito Federal e Entorno.

Degree: 2007, Universidade de Brasília

URL: http://bdtd.bce.unb.br/tedesimplificado/tde_busca/arquivo.php?codArquivo=2750

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The present study describes the genetic diversity of human papillomaviruses in women infected by HIV-1 in the Federal District and cities around. Two hundred cervical… (more)

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The present study describes the genetic diversity of human papillomaviruses in women infected by HIV-1 in the Federal District and cities around. Two hundred cervical smears of HIV positive women were submitted to cervical cytological examination and to PCR amplification. HPV DNA-positive samples were genotyped by RFLP. HPV prevalence was 41%, and most samples were positive for high-risk oncogenic HPV genotypes (72%). One hundred and sixty-one samples (80.5%) had benign cellular alterations or normal cytological results and the HPV DNA frequency among them was 29.2%. Otherwise, most samples (89.7%) with altered cytology were positive for HPV DNA. A high diversity of genotypes was observed: HPV-16 and -81 were the most prevalent (12.2%), followed by HPV-52 (9.8%), -35, -53, -58, -62, and -70 (7.3%), -33, and -66 (6.1%), -18, -31, -56, and -61 (4.9%), -71 (3.7%), -6b, -11, -39, -40, and -54 (2.4%), and -32, -59, -67, -68, -72, -85, and -102 (1.2%). New variants of the HPV-11, - 18, -33, -53, -59, -62, -66, -70, -81 and -102 were detected. Possible associations between the detection of HPV, cytological classification, age, HIV viral load, CD4 cell count, and antiretroviral treatment were examined. We observed a significantly higher prevalence of HPV infection in women under the age of 30. Statistical analysis suggested that the level of immunosuppression was associated with the prevalence of cytologic abnormalities, but not with HPV infection. Otherwise, HIV viral load was associated with detection of HPV DNA and of cytologic abnormalities. A significant association between the use of antiretroviral therapy and the presence of HPV or the detection of cytologic abnormalities was not verified. It could be concluded that a high proportion of HIV-infected women are infected with HPV and, frequently, with oncogenic genotypes of this virus, even when cytological evaluation does not show abnormal results.

O presente trabalho descreve a diversidade genética do HPV em mulheres infectadas pelo HIV-1 no Distrito Federal e Entorno. Duzentas amostras cervicais de mulheres HIV-positivas foram submetidas a exame citopatológico cervical e à amplificação por PCR. As amostras positivas para DNA do HPV foram genotipadas por RFLP. A positividade para HPV foi 41%, com a maioria das amostras positivas para genótipos de alto risco oncogênico (72%). Cento e sessenta e uma amostras (80,5%) tinham alterações celulares benignas ou resultados citopatológicos normais e a freqüência de HPV entre elas foi 29,2%. Por outro lado, a maioria das amostras com citologia alterada foi positiva para HPV (89,7%). Uma grande diversidade de genótipos foi observada: os HPVs-16 e 81 foram os mais prevalentes (12,2%), seguidos pelos HPVs 52 (9,8%), 35, 53, 58 62 e 70 (7,3%), 33 e 66 (6,1%), 18, 31, 56 e 61 (4,9%), 71 (3,7%), 6b, 11, 39, 40 e 54 (2,4%) e 32, 59, 67, 68, 72, 85 e 102 (1,2%). Novos variantes dos HPVs 11, 18, 33, 53, 59, 62, 66, 70, 81 e 102 foram detectados. Possíveis associações entre a detecção de HPV, a classificação citopatológica, a idade, a…

Advisors/Committee Members: Marcelo Brígido, Ildinete Silva Pereira, Cezar Martins de Sá, Elizabeth Maria Talá de Souza, Cláudia Renata Fernandes Martins, Laura Sichero.

Subjects/Keywords: HPV; HIV; Brasil; BIOLOGIA MOLECULAR

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Cerqueira, D. M. (2007). Prevalência, freqüência de genótipos e de variantes de Papilomavírus Humanos em mulheres co-infectadas com o vírus da Imunodeficiência Humana Tipo 1 no Distrito Federal e Entorno. (Thesis). Universidade de Brasília. Retrieved from http://bdtd.bce.unb.br/tedesimplificado/tde_busca/arquivo.php?codArquivo=2750

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Cerqueira, Daniela Marreco. “Prevalência, freqüência de genótipos e de variantes de Papilomavírus Humanos em mulheres co-infectadas com o vírus da Imunodeficiência Humana Tipo 1 no Distrito Federal e Entorno.” 2007. Thesis, Universidade de Brasília. Accessed April 21, 2018. http://bdtd.bce.unb.br/tedesimplificado/tde_busca/arquivo.php?codArquivo=2750.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Cerqueira, Daniela Marreco. “Prevalência, freqüência de genótipos e de variantes de Papilomavírus Humanos em mulheres co-infectadas com o vírus da Imunodeficiência Humana Tipo 1 no Distrito Federal e Entorno.” 2007. Web. 21 Apr 2018.

Vancouver:

Cerqueira DM. Prevalência, freqüência de genótipos e de variantes de Papilomavírus Humanos em mulheres co-infectadas com o vírus da Imunodeficiência Humana Tipo 1 no Distrito Federal e Entorno. [Internet] [Thesis]. Universidade de Brasília; 2007. [cited 2018 Apr 21]. Available from: http://bdtd.bce.unb.br/tedesimplificado/tde_busca/arquivo.php?codArquivo=2750.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Cerqueira DM. Prevalência, freqüência de genótipos e de variantes de Papilomavírus Humanos em mulheres co-infectadas com o vírus da Imunodeficiência Humana Tipo 1 no Distrito Federal e Entorno. [Thesis]. Universidade de Brasília; 2007. Available from: http://bdtd.bce.unb.br/tedesimplificado/tde_busca/arquivo.php?codArquivo=2750

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Miami

23. Lopez, Corina Reyes. Effects of a Cognitive Behavioral Stress Management Intervention on the Psychological, Endocrinological, and Immunological Health of Minority Women Co-infected with HIV and HPV.

Degree: MS, Psychology (Arts and Sciences), 2010, University of Miami

URL: http://scholarlyrepository.miami.edu/oa_theses/63

► Women infected with HIV are at an increased risk for infection of Human Papillomavirus (HPV), developing cervical lesions, and developing cervical cancer. Prior research has… (more)

▼ Women infected with HIV are at an increased risk for infection of Human Papillomavirus (HPV), developing cervical lesions, and developing cervical cancer. Prior research has suggested disruptions in the immune system as well as circulating levels of stress and gonadal hormones as possible explanations for the increase of HPV infection in women with HIV. Additionally, psychosocial factors such as symptoms of depression and distress have also been associated with HPV infection, as well as disruptions in immune and endocrinologial systems, suggesting a psychoneuroimmunological pathway to disease progression. It was hypothesized that HIV+HPV+ women assigned to a Cognitive Behavioral Stress Management (CBSM) intervention will experience improvements in disease status, immune markers, circulating stress hormones, and reductions of depression and distress symptoms. An exploratory investigation of the effects of CBSM in levels circulating reproductive hormones was also tested. Follow-up hypotheses tested whether CBSM effects on immune variables were explained by reductions in symptoms of depression, distress, NE, cortisol, and increases of DHEA-S. Additionally, it was hypothesized that CBSM effects on stress hormones would be mediated by reductions in distress and depression symptoms. Finally, it was hypothesized that improvements in immune parameters would be correlated with decreases in risk of cervical dysplasia at a 9 month follow-up. Participants were 71 women co-infected with HIV and HPV that were mostly of African American, Haitian, Latina, and Caribbean descent. Hierarchical regression analyses were performed and showed a significant CBSM effect in decreases on BDI somatic depression subscale scores and increases in NK cell counts. Additionally, there was a marginally significant effect of CBSM on increases in CD4+ T-cells and decreases in urinary NE output. The bootstrapping method evidenced a mediation model, where the relationship between group assignment and CD4+ cell counts was explained by lower BDI somatic scores. More research is necessary to fully elucidate the psychobiological trajectories of disease as immunological changes in our sample did not explain the reduced odds of dysplasia in the women assigned to the CBSM group. Advisors/Committee Members: Frank Penedo - Committee Member, Michael Antoni - Mentor, Mary Ann Fletcher - Outside Committee Member.

Subjects/Keywords: HIV; HPV; CBSM Intervention

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Lopez, C. R. (2010). Effects of a Cognitive Behavioral Stress Management Intervention on the Psychological, Endocrinological, and Immunological Health of Minority Women Co-infected with HIV and HPV. (Thesis). University of Miami. Retrieved from http://scholarlyrepository.miami.edu/oa_theses/63

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Lopez, Corina Reyes. “Effects of a Cognitive Behavioral Stress Management Intervention on the Psychological, Endocrinological, and Immunological Health of Minority Women Co-infected with HIV and HPV.” 2010. Thesis, University of Miami. Accessed April 21, 2018. http://scholarlyrepository.miami.edu/oa_theses/63.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Lopez, Corina Reyes. “Effects of a Cognitive Behavioral Stress Management Intervention on the Psychological, Endocrinological, and Immunological Health of Minority Women Co-infected with HIV and HPV.” 2010. Web. 21 Apr 2018.

Vancouver:

Lopez CR. Effects of a Cognitive Behavioral Stress Management Intervention on the Psychological, Endocrinological, and Immunological Health of Minority Women Co-infected with HIV and HPV. [Internet] [Thesis]. University of Miami; 2010. [cited 2018 Apr 21]. Available from: http://scholarlyrepository.miami.edu/oa_theses/63.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Lopez CR. Effects of a Cognitive Behavioral Stress Management Intervention on the Psychological, Endocrinological, and Immunological Health of Minority Women Co-infected with HIV and HPV. [Thesis]. University of Miami; 2010. Available from: http://scholarlyrepository.miami.edu/oa_theses/63

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Miami

24. Kornfeld, Julie. Factors Associated with Acceptance of Human Papillomavirus Vaccine: A Study of Spanish Information Seekers.

Degree: PhD, Epidemiology (Medicine), 2009, University of Miami

URL: http://scholarlyrepository.miami.edu/oa_dissertations/346

► Cervical cancer is the second most common malignancy worldwide. Infection with HPV is a necessary cause of cervical. Hispanic women in the U.S. experience… (more)

▼ Cervical cancer is the second most common malignancy worldwide. Infection with HPV is a necessary cause of cervical. Hispanic women in the U.S. experience significantly higher rates of invasive disease than non-Hispanic Whites. In this population, HPV vaccines hold significant potential to eliminate further disparities in cervical cancer morbidity and mortality. The purpose of this study was to examine factors associated with Human Papillomavirus (HPV) vaccine acceptability among a national sample of Spanish speaking callers to the National Cancer Institute's (NCI) Cancer Information Service (CIS). Specifically this research aimed to identify the sociodemographic, sociocultural and attitudinal determinants of HPV vaccine acceptability. This research involved a cross-sectional study with phone-based interviews conducted in Spanish (n = 836). All female Spanish callers to the CIS were asked to respond to a three-part questionnaire that included items relating to ethnic identity and acculturation, knowledge of cervical cancer and related risk factors, and HPV vaccine acceptability. Descriptive, univariate and multivariate logistic regression were used to characterize the study population and to determine the effect of each of the demographic/sociocultural variables on vaccine acceptance. Independent predictors of HPV vaccine acceptability were determined using multivariate linear regression models. Results showed that HPV vaccine acceptance was high among this group of Hispanic women (78%) and that attitudes about vaccines in general and the HPV vaccine specifically were positive. Factors associated with vaccine acceptance included physician recommendation, awareness and accurate knowledge about HPV, and speaking only or mostly Spanish. Other important predictors included influence of peers, positive attitudes about vaccines in general, higher education and being a mother of a female adolescent. The primary reason cited by those who did not favor vaccination was concern over vaccine safety. This research was the first study looking at vaccine acceptability in a large, national sample of Hispanic women. HPV vaccination can lead to important public health benefits for Hispanic women. Targeted educational interventions must take into account the important sociocultural and attitudinal influences on the decision to vaccinate, such as those identified in the present study. Future educational efforts must involve the physician and take into the account the cultural context of attitudes and beliefs regarding vaccine safety and disease susceptibility. Further studies elucidating the interplay between culture specific beliefs and practices regarding vaccination and the decision to participate in HPV vaccination are needed. Advisors/Committee Members: David Lee - Committee Chair, Isildinha m. Reis, DrPH - Committee Member, Hosanna Soler-Vilan - Committee Member, Erin Kobetz , MPH - Committee Member, Anna R. Giuliano - Outside Committee Member.

Subjects/Keywords: Hispanic; Cervical Cancer; HPV Vaccine

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Kornfeld, J. (2009). Factors Associated with Acceptance of Human Papillomavirus Vaccine: A Study of Spanish Information Seekers. (Doctoral Dissertation). University of Miami. Retrieved from http://scholarlyrepository.miami.edu/oa_dissertations/346

Chicago Manual of Style (16^th Edition):

Kornfeld, Julie. “Factors Associated with Acceptance of Human Papillomavirus Vaccine: A Study of Spanish Information Seekers.” 2009. Doctoral Dissertation, University of Miami. Accessed April 21, 2018. http://scholarlyrepository.miami.edu/oa_dissertations/346.

MLA Handbook (7^th Edition):

Kornfeld, Julie. “Factors Associated with Acceptance of Human Papillomavirus Vaccine: A Study of Spanish Information Seekers.” 2009. Web. 21 Apr 2018.

Vancouver:

Kornfeld J. Factors Associated with Acceptance of Human Papillomavirus Vaccine: A Study of Spanish Information Seekers. [Internet] [Doctoral dissertation]. University of Miami; 2009. [cited 2018 Apr 21]. Available from: http://scholarlyrepository.miami.edu/oa_dissertations/346.

Council of Science Editors:

Kornfeld J. Factors Associated with Acceptance of Human Papillomavirus Vaccine: A Study of Spanish Information Seekers. [Doctoral Dissertation]. University of Miami; 2009. Available from: http://scholarlyrepository.miami.edu/oa_dissertations/346

Duke University

25. Shaw, Charlie. A Novel Mechanism for Human Papillomavirus Mediated Tumorigenesis: Examining a Role for HPV E6 Protein in CYLD Mediated NF-kappaB Activation.

Degree: 2009, Duke University

URL: http://hdl.handle.net/10161/1058

► Human papillomavirus (HPV) infection of mucosal epithelium by `high-risk' HPV types has a prominent role in the development of anogenital intraepithelial neoplasias and carcinomas.… (more)

▼ Human papillomavirus (HPV) infection of mucosal epithelium by `high-risk' HPV types has a prominent role in the development of anogenital intraepithelial neoplasias and carcinomas. Human epithelial cells transformed with the HPV E6 oncoprotein survive even under conditions that normally lead to cell apoptosis. This phenomenon has been attributed to HPV E6's ability to promote the degradation of the tumor suppressor protein p53. More recently, it has been demonstrated that HPV E6 contributes to activation of the NF-kB pathway. NF-kB is a transcription factor involved in the regulation of genes associated with cellular proliferation, apoptosis and inflammatory responses. In addition to p53 suppression, HPV E6 modulation of NF-kB activation presents another mechanism for HPV-driven tumorigenesis. However, it was not known how HPV E6 promotes NF-kB pathway activation. To address how HPV E6 leads to NF-kB activation, we identified an association between HPV E6 and the human cylindromatosis gene product (CYLD). CYLD is an endogenous inhibitor of canonical NF-kB activation. We showed that HPV E6 proteins could precipitate CYLD in vitro using a co-immunoprecipitation assay. Demonstrating that HPV E6 and CYLD proteins bind each other raised the possibility that this binding relationship would have a functional effect upon the NF-kB pathway by altering CYLD-mediated suppression of NF-kB activation. To identify HPV E6 functional relationship with CYLD and to determine how HPV E6 activates the NF-kB pathway, we transfected cells with either HPV E6 expression vectors containing the high-risk HPV type 16 E6 or the low-risk HPV type 11 E6 along with a CYLD expression vector. We showed HPV16 E6 expression in 293 cells blocked the ability of CYLD to inhibit CD40 ligand-stimulated NF-kB activation. Interestingly, HPV11 E6 was unable to inhibit CYLD mediated suppression of NF-kB in our system. CYLD had previously been shown to suppress NF-kB activation by removing stimulatory lysine 63-linked ubiquitin chains from TRAF2. We found CYLD expression in 293 cells leads to dose-dependent reduction in TRAF2 levels. This CYLD-mediated loss of TRAF2 is inhibited by co-expression of high-, but not low-risk E6 proteins. It was known that CYLD phosphorylation in vivo suppresses CYLD deubiquitination actions of canonical pathway proteins; we therefore tested the extent of CYLD phosphorylation when co-expressed with HPV E6, and discovered that CYLD phosphorylation was increased in the presence of HPV E6. This compilation of experiments suggests that with HPV16 E6 binding to CYLD, the E6 protein blocks CYLD-mediated TRAF2 loss and thereby TRAF2 is available to activate the canonical NF-κB pathway. Blocking HPV E6-mediated NF-kB activation may prove beneficial as a means for designing therapies that inhibit HPV-mediated tumorigenesis. The differences we detected between HPV11 E6 and HPV16 E6 are supported by other studies that showed E6 protein variations account for molecular and clinical differences among HPV infection outcomes. Similarly, there… Advisors/Committee Members: Alexander, Kenneth A (advisor).

Subjects/Keywords: Biology, Microbiology; CYLD; HPV

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APA (6^th Edition):

Shaw, C. (2009). A Novel Mechanism for Human Papillomavirus Mediated Tumorigenesis: Examining a Role for HPV E6 Protein in CYLD Mediated NF-kappaB Activation. (Thesis). Duke University. Retrieved from http://hdl.handle.net/10161/1058

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Shaw, Charlie. “A Novel Mechanism for Human Papillomavirus Mediated Tumorigenesis: Examining a Role for HPV E6 Protein in CYLD Mediated NF-kappaB Activation.” 2009. Thesis, Duke University. Accessed April 21, 2018. http://hdl.handle.net/10161/1058.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Shaw, Charlie. “A Novel Mechanism for Human Papillomavirus Mediated Tumorigenesis: Examining a Role for HPV E6 Protein in CYLD Mediated NF-kappaB Activation.” 2009. Web. 21 Apr 2018.

Vancouver:

Shaw C. A Novel Mechanism for Human Papillomavirus Mediated Tumorigenesis: Examining a Role for HPV E6 Protein in CYLD Mediated NF-kappaB Activation. [Internet] [Thesis]. Duke University; 2009. [cited 2018 Apr 21]. Available from: http://hdl.handle.net/10161/1058.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Shaw C. A Novel Mechanism for Human Papillomavirus Mediated Tumorigenesis: Examining a Role for HPV E6 Protein in CYLD Mediated NF-kappaB Activation. [Thesis]. Duke University; 2009. Available from: http://hdl.handle.net/10161/1058

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

California State University – Sacramento

26. Russell, Jessica C. The effect of message framing and perceived action risk on young women???s attitudes toward and intentions to get the human papillomavirus (HPV) vaccine.

Degree: MA, Communication Studies, 2010, California State University – Sacramento

URL: http://hdl.handle.net/10211.9/188

► The human papillomavirus (HPV) is the most prevalent sexually transmitted disease (STD) in the United States. In June of 2006, a vaccine aimed to protect… (more)

Subjects/Keywords: HPV; Communication; Perceived risk

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Russell, J. C. (2010). The effect of message framing and perceived action risk on young women???s attitudes toward and intentions to get the human papillomavirus (HPV) vaccine. (Masters Thesis). California State University – Sacramento. Retrieved from http://hdl.handle.net/10211.9/188

Chicago Manual of Style (16^th Edition):

Russell, Jessica C. “The effect of message framing and perceived action risk on young women???s attitudes toward and intentions to get the human papillomavirus (HPV) vaccine.” 2010. Masters Thesis, California State University – Sacramento. Accessed April 21, 2018. http://hdl.handle.net/10211.9/188.

MLA Handbook (7^th Edition):

Russell, Jessica C. “The effect of message framing and perceived action risk on young women???s attitudes toward and intentions to get the human papillomavirus (HPV) vaccine.” 2010. Web. 21 Apr 2018.

Vancouver:

Russell JC. The effect of message framing and perceived action risk on young women???s attitudes toward and intentions to get the human papillomavirus (HPV) vaccine. [Internet] [Masters thesis]. California State University – Sacramento; 2010. [cited 2018 Apr 21]. Available from: http://hdl.handle.net/10211.9/188.

Council of Science Editors:

Russell JC. The effect of message framing and perceived action risk on young women???s attitudes toward and intentions to get the human papillomavirus (HPV) vaccine. [Masters Thesis]. California State University – Sacramento; 2010. Available from: http://hdl.handle.net/10211.9/188

Universiteit Utrecht

27. Misset, J. Mucosal immunity of the female genital tract after HPV infection and vaccination.

Degree: 2013, Universiteit Utrecht

URL: http://dspace.library.uu.nl:8080/handle/1874/273276

► Human papillomavirus is one of the most common sexually transmitted pathogens. HPV infections are associated with the development of cervical cancer, other genital cancers and… (more)

Subjects/Keywords: HPV; mucosal; vaccines; papillomavirus

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Misset, J. (2013). Mucosal immunity of the female genital tract after HPV infection and vaccination. (Masters Thesis). Universiteit Utrecht. Retrieved from http://dspace.library.uu.nl:8080/handle/1874/273276

Chicago Manual of Style (16^th Edition):

Misset, J. “Mucosal immunity of the female genital tract after HPV infection and vaccination.” 2013. Masters Thesis, Universiteit Utrecht. Accessed April 21, 2018. http://dspace.library.uu.nl:8080/handle/1874/273276.

MLA Handbook (7^th Edition):

Misset, J. “Mucosal immunity of the female genital tract after HPV infection and vaccination.” 2013. Web. 21 Apr 2018.

Vancouver:

Misset J. Mucosal immunity of the female genital tract after HPV infection and vaccination. [Internet] [Masters thesis]. Universiteit Utrecht; 2013. [cited 2018 Apr 21]. Available from: http://dspace.library.uu.nl:8080/handle/1874/273276.

Council of Science Editors:

Misset J. Mucosal immunity of the female genital tract after HPV infection and vaccination. [Masters Thesis]. Universiteit Utrecht; 2013. Available from: http://dspace.library.uu.nl:8080/handle/1874/273276

28. Martins, Albert Eduardo Silva. Avaliação prognóstica do índice de dna em amostras cervicais de mulheres coinfectadas HIV-HPV atendidas em centros de referência para HIV-AIDS em Recife .

Degree: 2013, Universidade Federal de Pernambuco

URL: http://repositorio.ufpe.br/handle/123456789/11687

► Pacientes HIV-positivo possuem uma maior prevalência de co-infecção por HPV de alto risco oncogênico. A presença viral favorece a progressão de lesões escamosas intra-epiteliais e… (more)

▼ Pacientes HIV-positivo possuem uma maior prevalência de co-infecção por HPV de alto risco oncogênico. A presença viral favorece a progressão de lesões escamosas intra-epiteliais e podem induzir ao câncer. O objetivo do presente estudo foi avaliar a prevalência, distribuição dos tipos virais e fatores de risco para a infecção pelo HPV em pacientes infectados por HIV. Amostras cervicais de 450 mulheres infectadas pelo HIV foram analisadas quanto à citologia oncótica, colposcopia, presença e tipagem de HPV através de PCR e sequenciamento utilizando os iniciadores MY09 e MY11. Os resultados foram analisados comparando dados demográficos, e outros relacionados com a infecção pelo HPV e HIV. A prevalência de HPV foi de 47,5%. Das amostras positivas para o HPV, 59% albergavam tipos de alto risco oncogênico. Análise multivariada confirmou a associação da infecção pelo HPV com a presença de alterações à citologia (p=0,003), idade maior ou igual a 35 anos (p=0,002); número de parceiros maior que três (p=0,002); contagem de linfócitos T CD4+ < 200/mm3 (p=0,041), e etilismo (p=0,004). Apesar da presença de HPV de alto risco na maioria das lesões estudadas, a baixa freqüência de HPV 16 (3,3%) e o estado imunológico preservado na maioria das pacientes HIV-positivas, são fatores que podem explicar a baixa ocorrência de lesões cervicais pré-cancerosas nessa população. A persistência da infecção cervical por tipos de alto risco oncogênicos de papiloma vírus humano (HPV) pode levar a neoplasisas intra-epitliais cervicais (NIC). O objetivo do presente estudo foi o de avaliar, em mulheres infectadas pelo HIV, se a presença de aneuploidia em amostras de células cervicais está associda à presença e à evolução de NIC. O presente estudo constou de 2 etapas. Na primeira etapa, correspondendo a um corte transversal , analisou-se a associação entre a presença de aneuloidia por citometria de fluxo e características sócio-demográficas, hábitos e características ligadas à infecção pelo HPV e HIV. Na segunda etapa, correspondendo a uma coorte, verificou-se se a aneuploidia era preditiva da evolução da NIC. Não observou-se associação entre a presença de aneuploidia e a infecção por HPV, nem com alterações à citologia oncótica. Por outro lado, a aneuploidia esteve associada à presença de NIC (p=0,03?) no exame histológico e ao não uso de TARV (p=0,001). A maioria das mulheres infectadas por HIV (234/272) apresentaram contagem de linfócito T CD4+ normal (acima de 350células /mm3) e mostraram uma maior taxa de regressão (77,5%) da aneuploidia comparadas à taxa de progressão (23,9%) em até dois anos de seguimento. Embora tenha sido encontrada uma associação entre a presença da lesão tecidual cervical e o índice de DNA, este não foi preditivo da evolução da lesão cervical, sugerindo que a progressão da lesão cervical para o câncer em mulheres HIV-positivas também pode ser alterada pela melhoria do estado imunológico propiciado pelo uso de terapia anti-retrovirial (TARV). Advisors/Committee Members: Ximenes, Ricardo Arraes de Alencar (advisor), Silva, Norma Lucena Cavalcanti Licínio da (advisor).

Subjects/Keywords: Prevalência de HPV; Distribuição de tipos de HPV; Coinfecção HIV-HPV; Fatores de risco; Tipos de HPV; Ploidia de DNA

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Martins, A. E. S. (2013). Avaliação prognóstica do índice de dna em amostras cervicais de mulheres coinfectadas HIV-HPV atendidas em centros de referência para HIV-AIDS em Recife . (Thesis). Universidade Federal de Pernambuco. Retrieved from http://repositorio.ufpe.br/handle/123456789/11687

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Martins, Albert Eduardo Silva. “Avaliação prognóstica do índice de dna em amostras cervicais de mulheres coinfectadas HIV-HPV atendidas em centros de referência para HIV-AIDS em Recife .” 2013. Thesis, Universidade Federal de Pernambuco. Accessed April 21, 2018. http://repositorio.ufpe.br/handle/123456789/11687.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Martins, Albert Eduardo Silva. “Avaliação prognóstica do índice de dna em amostras cervicais de mulheres coinfectadas HIV-HPV atendidas em centros de referência para HIV-AIDS em Recife .” 2013. Web. 21 Apr 2018.

Vancouver:

Martins AES. Avaliação prognóstica do índice de dna em amostras cervicais de mulheres coinfectadas HIV-HPV atendidas em centros de referência para HIV-AIDS em Recife . [Internet] [Thesis]. Universidade Federal de Pernambuco; 2013. [cited 2018 Apr 21]. Available from: http://repositorio.ufpe.br/handle/123456789/11687.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Martins AES. Avaliação prognóstica do índice de dna em amostras cervicais de mulheres coinfectadas HIV-HPV atendidas em centros de referência para HIV-AIDS em Recife . [Thesis]. Universidade Federal de Pernambuco; 2013. Available from: http://repositorio.ufpe.br/handle/123456789/11687

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

29. Mirella de Mattos Melo, Suany. Associação de polimorfismos nos genes MBL e β-defensina com infecção pelo HPV e/ou HIV em região anal e perianal .

Degree: 2008, Universidade Federal de Pernambuco

URL: http://repositorio.ufpe.br/handle/123456789/1508

► O papilomavírus humano (HPV) é um dos mais importantes agentes etiológicos envolvidos no desenvolvimento do câncer cervical. Dois dos principais fatores de risco envolvidos no… (more)

Subjects/Keywords: HIV; HPV; hBD; MBL; coinfecção

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Mirella de Mattos Melo, S. (2008). Associação de polimorfismos nos genes MBL e β-defensina com infecção pelo HPV e/ou HIV em região anal e perianal . (Thesis). Universidade Federal de Pernambuco. Retrieved from http://repositorio.ufpe.br/handle/123456789/1508

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Mirella de Mattos Melo, Suany. “Associação de polimorfismos nos genes MBL e β-defensina com infecção pelo HPV e/ou HIV em região anal e perianal .” 2008. Thesis, Universidade Federal de Pernambuco. Accessed April 21, 2018. http://repositorio.ufpe.br/handle/123456789/1508.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Mirella de Mattos Melo, Suany. “Associação de polimorfismos nos genes MBL e β-defensina com infecção pelo HPV e/ou HIV em região anal e perianal .” 2008. Web. 21 Apr 2018.

Vancouver:

Mirella de Mattos Melo S. Associação de polimorfismos nos genes MBL e β-defensina com infecção pelo HPV e/ou HIV em região anal e perianal . [Internet] [Thesis]. Universidade Federal de Pernambuco; 2008. [cited 2018 Apr 21]. Available from: http://repositorio.ufpe.br/handle/123456789/1508.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Mirella de Mattos Melo S. Associação de polimorfismos nos genes MBL e β-defensina com infecção pelo HPV e/ou HIV em região anal e perianal . [Thesis]. Universidade Federal de Pernambuco; 2008. Available from: http://repositorio.ufpe.br/handle/123456789/1508

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

30. SANTANA, Nataly Amorim de. Influência da dinâmica conformacional da E1 Helicase de Papillomavírus na interação com ligantes .

Degree: 2011, Universidade Federal de Pernambuco

URL: http://repositorio.ufpe.br/handle/123456789/1676

► A infecção pelo papillomavirus humano (HPV) é o principal agente causal para o desenvolvimento de câncer de colo uterino que é a segunda causa de… (more)

▼ A infecção pelo papillomavirus humano (HPV) é o principal agente causal para o desenvolvimento de câncer de colo uterino que é a segunda causa de morte por câncer em mulheres no mundo e o segundo tipo de câncer mais frequente em mulheres na faixa etária de 15 a 44 anos. Além disso, é cada vez mais frequente a infecção por HPV em diferentes locais do corpo humano ocasionando tanto lesões malignas quanto benignas. Dada à importância clínica na saúde pública mundial desta infecção, têm surgido esforços da comunidade científica a fim de desenvolver fármacos que possam inibir e/ou impedir a infecção desse vírus. Neste sentido, a proteína E1 é uma das proteínas virais que têm sido investigadas como um alvo potencial para o desenvolvimento destes fármacos, já que a mesma é uma DNA helicase que participa do processo de replicação viral. O potencial de derivados do ácido bifenilsulfonacético na inibição da atividade ATPase de E1 foi verificado em estudos anteriores. O derivado n° 9 teve maior eficácia na inibição da atividade ATPase da E1 helicase de HPV6 do que na E1 helicase de HPV11. Como não foi encontrado nenhum outro sítio de ligação além do sítio ATPase na E1 de HPV18, esta diferença de inibição observada entre os HPVs estudados foi atribuída a ligação do derivado n° 9 ao aminoácido Y486 de HPV6 que resulta uma mudança conformacional no sítio ATPase e consequentemente impede a ligação do ATP. Assim, o objetivo deste trabalho foi utilizar o docking e a dinâmica molecular a fim de compreender o modo de ligação do derivado nº 9 do ácido bifenilsulfonacético na E1 helicase de HPV, além de determinar a influência dos resíduos de aminoácidos localizados no sítio ATPase na afinidade com o inibidor. Os resultados mostraram que o derivado nº 9 do ácido bifenilsulfonacético e o ATP competem pelo mesmo sítio de ligação e, além disso, as mobilidades observadas no P-loop e nos resíduos de aminoácidos A486, K490, S491 e Y492 do sítio ATPase podem determinar a diferença de afinidade do complexo proteína-inibidor Advisors/Committee Members: LIMA FILHO, José Luiz de (advisor).

Subjects/Keywords: HPV; E1 helicase; Ácido Bifenilsulfonacético

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

SANTANA, N. A. d. (2011). Influência da dinâmica conformacional da E1 Helicase de Papillomavírus na interação com ligantes . (Thesis). Universidade Federal de Pernambuco. Retrieved from http://repositorio.ufpe.br/handle/123456789/1676

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

SANTANA, Nataly Amorim de. “Influência da dinâmica conformacional da E1 Helicase de Papillomavírus na interação com ligantes .” 2011. Thesis, Universidade Federal de Pernambuco. Accessed April 21, 2018. http://repositorio.ufpe.br/handle/123456789/1676.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

SANTANA, Nataly Amorim de. “Influência da dinâmica conformacional da E1 Helicase de Papillomavírus na interação com ligantes .” 2011. Web. 21 Apr 2018.

Vancouver:

SANTANA NAd. Influência da dinâmica conformacional da E1 Helicase de Papillomavírus na interação com ligantes . [Internet] [Thesis]. Universidade Federal de Pernambuco; 2011. [cited 2018 Apr 21]. Available from: http://repositorio.ufpe.br/handle/123456789/1676.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

SANTANA NAd. Influência da dinâmica conformacional da E1 Helicase de Papillomavírus na interação com ligantes . [Thesis]. Universidade Federal de Pernambuco; 2011. Available from: http://repositorio.ufpe.br/handle/123456789/1676

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Open Access Theses and Dissertations