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1. Strub, Thomas. Mode d'action du facteur de transcription MITF dans la physiopathologie des cellules de mélanome humain : Role of the transcription factor MITF in the physiopathology of human melanoma cells.

Degree: Docteur es, Aspects moléculaires et cellulaires de la biologie, 2012, Université de Strasbourg

MITF (MIcrophthalmia-associated Transcription Factor) contrôle de multiples aspects de la physiopathologie du lignage mélanocytaire. Par des techniques de génomique haut débit (ChIP-seq, RNA-seq), nous avons montré que MITF active un ensemble de gènes impliqués dans la réplication et la réparation de l’ADN ainsi que la mitose pour stimuler la prolifération des cellules de mélanome, et réprime des gènes contrôlant leur caractère invasif. Pour étudier le mécanisme d’action de MITF, son interactome a été déterminé par spectrométrie de masse mettant en évidence de nombreux partenaires à activité co-activateur ou co-répresseur (bcaténine, complexes de remodelage de la chromatine BRG1 et NURF) ainsi que des facteurs intervenant dans le cycle de l’ubiquitination et de déubuquitination (HERC2 et USP11). Une caractérisation fonctionnelle de HERC2 et USP11 suggère qu’ils agissent comme des cofacteurs transcriptionnels de MITF essentiels pour la prolifération des cellules de mélanome.

MITF (MIcrophthalmia-associated Transcription Factor) controls multiple aspects of the physiopathology of the melanocyte lineage. Using high throughput genomics techniques (ChIP-seq, RNA-seq), we show that MITF activates a set of genes involved in DNA replication and repair as well as mitosis to promote melanoma cell proliferation, while repressing genes involved in promoting their invasion. To better understand how MITF acts both as a transcriptional activator and repressor, we characterized the MITF interactome by tandem immuno-affinity purification and mass-spectrometry. A complex set of partners with coactivatoror co-repressor properties were identified (b-catenin, the BRG1 and NURF chromatin remodeling complexes) as well as novel factors with ubiquitin E3 ligase (HERC2) and ubiquitin-specific protease (USP11) activities. Functional characterization of HERC2 and USP11 suggests that they act as transcriptional cofactors for MITF essential for melanoma cell proliferation.

Advisors/Committee Members: Davidson, Irwin (thesis director).

Subjects/Keywords: Mélanome; MITF; Réparation de l’ADN; USP11; HERC2; Melanoma; MITF; DNA reparation; USP11; HERC2; 572.8; 616.99

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Strub, T. (2012). Mode d'action du facteur de transcription MITF dans la physiopathologie des cellules de mélanome humain : Role of the transcription factor MITF in the physiopathology of human melanoma cells. (Doctoral Dissertation). Université de Strasbourg. Retrieved from http://www.theses.fr/2012STRAJ104

Chicago Manual of Style (16th Edition):

Strub, Thomas. “Mode d'action du facteur de transcription MITF dans la physiopathologie des cellules de mélanome humain : Role of the transcription factor MITF in the physiopathology of human melanoma cells.” 2012. Doctoral Dissertation, Université de Strasbourg. Accessed December 13, 2019. http://www.theses.fr/2012STRAJ104.

MLA Handbook (7th Edition):

Strub, Thomas. “Mode d'action du facteur de transcription MITF dans la physiopathologie des cellules de mélanome humain : Role of the transcription factor MITF in the physiopathology of human melanoma cells.” 2012. Web. 13 Dec 2019.

Vancouver:

Strub T. Mode d'action du facteur de transcription MITF dans la physiopathologie des cellules de mélanome humain : Role of the transcription factor MITF in the physiopathology of human melanoma cells. [Internet] [Doctoral dissertation]. Université de Strasbourg; 2012. [cited 2019 Dec 13]. Available from: http://www.theses.fr/2012STRAJ104.

Council of Science Editors:

Strub T. Mode d'action du facteur de transcription MITF dans la physiopathologie des cellules de mélanome humain : Role of the transcription factor MITF in the physiopathology of human melanoma cells. [Doctoral Dissertation]. Université de Strasbourg; 2012. Available from: http://www.theses.fr/2012STRAJ104

2. Rosell, Rafael. Combinatory effect of BRCA1 and HERC2 expression on outcome in advanced non-small-cell lung cancer.

Degree: 2018, BioMed Central

Subjects/Keywords: BRCA1; HERC2; Non-small-cell lung cancer; Platinum; Predictive markers; DNA repair; Medicina

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Rosell, R. (2018). Combinatory effect of BRCA1 and HERC2 expression on outcome in advanced non-small-cell lung cancer. (Thesis). BioMed Central. Retrieved from http://hdl.handle.net/10486/676637

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Rosell, Rafael. “Combinatory effect of BRCA1 and HERC2 expression on outcome in advanced non-small-cell lung cancer.” 2018. Thesis, BioMed Central. Accessed December 13, 2019. http://hdl.handle.net/10486/676637.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Rosell, Rafael. “Combinatory effect of BRCA1 and HERC2 expression on outcome in advanced non-small-cell lung cancer.” 2018. Web. 13 Dec 2019.

Vancouver:

Rosell R. Combinatory effect of BRCA1 and HERC2 expression on outcome in advanced non-small-cell lung cancer. [Internet] [Thesis]. BioMed Central; 2018. [cited 2019 Dec 13]. Available from: http://hdl.handle.net/10486/676637.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Rosell R. Combinatory effect of BRCA1 and HERC2 expression on outcome in advanced non-small-cell lung cancer. [Thesis]. BioMed Central; 2018. Available from: http://hdl.handle.net/10486/676637

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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