subject:(Glycated hemoglobin)

Indian Institute of Science

1. Siva Rama Krishna, V. Towards Development Of Low Cost Electrochemical Biosensor For Detecting Percentage Glycated Hemoglobin.

Degree: 2012, Indian Institute of Science

URL: http://hdl.handle.net/2005/2340

► There is an ever growing demand for low cost biosensors in medical diagnostics. A well known commercially successful example is glucose biosensors which are used… (more)

▼ There is an ever growing demand for low cost biosensors in medical diagnostics. A well known commercially successful example is glucose biosensors which are used to diagonize and monitor diabetes. These biosensors use electrochemical analysis (electro analysis) as transduction mechanism. Electro analytical techniques involve application of electrical stimulus to the chemical/biochemical system under consideration and measurement of electrical response due to the oxidation and reduction reactions that occur because of the stimulus. They offer a lot of advantages in terms of sensitivity, selectivity, cost effectiveness and compatibility towards integration with electronics. Besides glucose, there are several biomolecules of significance for which electro analysis can potentially be used to develop low cost, rapid, easy to use biosensors. One such biomolecule is Glycated Hemoglobin (GHb). It is a post translational, non-enzymatic modification of hemoglobin with glucose and is a very good biomarker that indicates the average value of blood glucose over the past 120 days. It is always expresses as a percentage of total hemoglobin present in blood. Monitoring diabetes based on the value of percentage Glycated hemoglobin is advantageous as it gives an average value of glucose unlike plasma glucose values which vary a lot on a day to day basis depending on the dietary habits and the stress levels of the individual. This thesis is focused on the development of a low coat, easy to use, disposable sensor for measuring percentage Glycated hemoglobin. The first challenge in developing such a sensor is isolation of hemoglobin. Unlike glucose which is present in blood plasma (liquid content of blood), hemoglobin resides inside red blood cells also known as erythrocytes. O isolate hemoglobin, these cells have to be broken or lysed. All the existing approaches rely on mixing blood with lysing reagents to lyse erythrocytes. Ideal biosensors should be devoid of liquid reagents. Keeping this in perspective, in this thesis, this challenge is addressed by developing two entirely buffer/reagentless techniques to lyse erythrocytes and isolate hemoglobin. In the first technique, cellulose acetate membranes are embedded with lysing reagents and are used for lysing reagents and are used for lysing application. In the second techniques, commercially available nylon mesh nets are modified with lysing reagents to lyse and isolate hemoglobin. These membranes or mesh nets can be easily integrated on top of a disposable strip. After isolating hemoglobin, the next challenge is to selectively detect Glycated hemoglobin. Boronic acid conjugates are known to bind Glycated hemoglobin. Using this principle, a new composite is sysnthesized to specifically detect glc\ycated hemoglobin. The composite (GO-APBA) is a result of functionalization of Graphene Oxide (GO) with 3-aminophenylboronic acide (APBA). Detection of Glycated hemoglobin is achieved by modifying screen printed electrode strips with the synthesized compound, thus taking a step forwards… Advisors/Committee Members: Amrutur, Bharadwaj.

Subjects/Keywords: Medical Diagnostics; Electrochemical Diagnosis; Biosensors; Glycated Hemoglobin (GHb); Electrochemical Biosensors; Glycated Hemoglobin - Electrochemical Detection; Erythrocytes - Lysis; Glycated Hemoglobin - Biosensors; Glycated Hemoglobin Sensor; Pathology

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Siva Rama Krishna, V. (2012). Towards Development Of Low Cost Electrochemical Biosensor For Detecting Percentage Glycated Hemoglobin. (Thesis). Indian Institute of Science. Retrieved from http://hdl.handle.net/2005/2340

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Siva Rama Krishna, V. “Towards Development Of Low Cost Electrochemical Biosensor For Detecting Percentage Glycated Hemoglobin.” 2012. Thesis, Indian Institute of Science. Accessed January 15, 2019. http://hdl.handle.net/2005/2340.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Siva Rama Krishna, V. “Towards Development Of Low Cost Electrochemical Biosensor For Detecting Percentage Glycated Hemoglobin.” 2012. Web. 15 Jan 2019.

Vancouver:

Siva Rama Krishna V. Towards Development Of Low Cost Electrochemical Biosensor For Detecting Percentage Glycated Hemoglobin. [Internet] [Thesis]. Indian Institute of Science; 2012. [cited 2019 Jan 15]. Available from: http://hdl.handle.net/2005/2340.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Siva Rama Krishna V. Towards Development Of Low Cost Electrochemical Biosensor For Detecting Percentage Glycated Hemoglobin. [Thesis]. Indian Institute of Science; 2012. Available from: http://hdl.handle.net/2005/2340

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Indian Institute of Science

2. Siva Rama Krishna, V. Towards Development Of Low Cost Electrochemical Biosensor For Detecting Percentage Glycated Hemoglobin.

Degree: 2012, Indian Institute of Science

URL: http://etd.iisc.ernet.in/handle/2005/2340 ; http://etd.ncsi.iisc.ernet.in/abstracts/3010/G25329-Abs.pdf

► There is an ever growing demand for low cost biosensors in medical diagnostics. A well known commercially successful example is glucose biosensors which are used… (more)

▼ There is an ever growing demand for low cost biosensors in medical diagnostics. A well known commercially successful example is glucose biosensors which are used to diagonize and monitor diabetes. These biosensors use electrochemical analysis (electro analysis) as transduction mechanism. Electro analytical techniques involve application of electrical stimulus to the chemical/biochemical system under consideration and measurement of electrical response due to the oxidation and reduction reactions that occur because of the stimulus. They offer a lot of advantages in terms of sensitivity, selectivity, cost effectiveness and compatibility towards integration with electronics. Besides glucose, there are several biomolecules of significance for which electro analysis can potentially be used to develop low cost, rapid, easy to use biosensors. One such biomolecule is Glycated Hemoglobin (GHb). It is a post translational, non-enzymatic modification of hemoglobin with glucose and is a very good biomarker that indicates the average value of blood glucose over the past 120 days. It is always expresses as a percentage of total hemoglobin present in blood. Monitoring diabetes based on the value of percentage Glycated hemoglobin is advantageous as it gives an average value of glucose unlike plasma glucose values which vary a lot on a day to day basis depending on the dietary habits and the stress levels of the individual. This thesis is focused on the development of a low coat, easy to use, disposable sensor for measuring percentage Glycated hemoglobin. The first challenge in developing such a sensor is isolation of hemoglobin. Unlike glucose which is present in blood plasma (liquid content of blood), hemoglobin resides inside red blood cells also known as erythrocytes. O isolate hemoglobin, these cells have to be broken or lysed. All the existing approaches rely on mixing blood with lysing reagents to lyse erythrocytes. Ideal biosensors should be devoid of liquid reagents. Keeping this in perspective, in this thesis, this challenge is addressed by developing two entirely buffer/reagentless techniques to lyse erythrocytes and isolate hemoglobin. In the first technique, cellulose acetate membranes are embedded with lysing reagents and are used for lysing reagents and are used for lysing application. In the second techniques, commercially available nylon mesh nets are modified with lysing reagents to lyse and isolate hemoglobin. These membranes or mesh nets can be easily integrated on top of a disposable strip. After isolating hemoglobin, the next challenge is to selectively detect Glycated hemoglobin. Boronic acid conjugates are known to bind Glycated hemoglobin. Using this principle, a new composite is sysnthesized to specifically detect glc\ycated hemoglobin. The composite (GO-APBA) is a result of functionalization of Graphene Oxide (GO) with 3-aminophenylboronic acide (APBA). Detection of Glycated hemoglobin is achieved by modifying screen printed electrode strips with the synthesized compound, thus taking a step forwards… Advisors/Committee Members: Amrutur, Bharadwaj.

Subjects/Keywords: Medical Diagnostics; Electrochemical Diagnosis; Biosensors; Glycated Hemoglobin (GHb); Electrochemical Biosensors; Glycated Hemoglobin - Electrochemical Detection; Erythrocytes - Lysis; Glycated Hemoglobin - Biosensors; Glycated Hemoglobin Sensor; Pathology

Record Details Similar Records Cite « Share

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Siva Rama Krishna, V. (2012). Towards Development Of Low Cost Electrochemical Biosensor For Detecting Percentage Glycated Hemoglobin. (Thesis). Indian Institute of Science. Retrieved from http://etd.iisc.ernet.in/handle/2005/2340 ; http://etd.ncsi.iisc.ernet.in/abstracts/3010/G25329-Abs.pdf

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Siva Rama Krishna, V. “Towards Development Of Low Cost Electrochemical Biosensor For Detecting Percentage Glycated Hemoglobin.” 2012. Thesis, Indian Institute of Science. Accessed January 15, 2019. http://etd.iisc.ernet.in/handle/2005/2340 ; http://etd.ncsi.iisc.ernet.in/abstracts/3010/G25329-Abs.pdf.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Siva Rama Krishna, V. “Towards Development Of Low Cost Electrochemical Biosensor For Detecting Percentage Glycated Hemoglobin.” 2012. Web. 15 Jan 2019.

Vancouver:

Siva Rama Krishna V. Towards Development Of Low Cost Electrochemical Biosensor For Detecting Percentage Glycated Hemoglobin. [Internet] [Thesis]. Indian Institute of Science; 2012. [cited 2019 Jan 15]. Available from: http://etd.iisc.ernet.in/handle/2005/2340 ; http://etd.ncsi.iisc.ernet.in/abstracts/3010/G25329-Abs.pdf.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Siva Rama Krishna V. Towards Development Of Low Cost Electrochemical Biosensor For Detecting Percentage Glycated Hemoglobin. [Thesis]. Indian Institute of Science; 2012. Available from: http://etd.iisc.ernet.in/handle/2005/2340 ; http://etd.ncsi.iisc.ernet.in/abstracts/3010/G25329-Abs.pdf

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Vilnius University

3. Žilytė, Diana. Cukrinio diabeto monitoravimo laboratorinių rodiklių metodologinė analizė.

Degree: Master, 2014, Vilnius University

URL: http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2006~D_20140702_193728-67988 ;

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Daug pasaulinių organizacijų, kurios stengiasi pagerinti cukrinio diabeto diagnostiką ir sergančių pacientų glikemijos kontrolę, nes nepakankama ir vėlyva diagnostika skatina komplikacijų atsiradimą ir progresavimą. Šio… (more)

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Daug pasaulinių organizacijų, kurios stengiasi pagerinti cukrinio diabeto diagnostiką ir sergančių pacientų glikemijos kontrolę, nes nepakankama ir vėlyva diagnostika skatina komplikacijų atsiradimą ir progresavimą. Šio darbo tikslas išanalizuoti cukriniu diabetu sergančių pacientų metodologinių ypatumų įtaką glikozilinto hemoglobino rezultatams. Išmatavus analitę HbA1c, 100 pacientų sergančių cukriniu diabetu, trimis skirtingos standartizacijos analizinėmis sistemomis Roche-Hitachi 917, Bayer-Advia1650 ir Dade Behring-Dimension RxL, gauta koreliacija su trijų mėnesių gliukozės koncentracijos vidurkiu. Lyginant HbA1c rezultatus, referentiniu metodu Roche-Hitachi 917 analizine sistema, standartizuota Tarptautinės klinikinės chemijos ir laboratorinės medicinos federacijos (IFCC) ir Diabeto kontrolės ir komplikacijų tyrimų (DCCT), gautas skirtumas. Bayer-Advia1650 analizinė sistema, kurios HbA1c metodas standartizuotas Nacionalinės glikohemoglobino standartizacijos programos (NGSP), lyginant su mūsų referentinio metodo rezultatais, kai IFCC standartizacija r = 1.017 [0.883 iki 1.188]; y = 3.068 [1.894 iki 4.142]; n = 52; p = 0.0000001, o kai standartizacija DCCT r = 1.132 [1.060 iki 1.209]; y = 0.282 [-0.476 iki 0.990]; n = 53; p = 0.001. Dade Behring-Dimension RxL analizinės sistemos metodas standartizuotas pagal Diabeto kontrolės ir komplikacijų tyrimus (DCCT) palyginus su IFCC standartizuotu metodu rezultatais: r = 0.886 [0.767 iki 1.021]; y = 2.422 [1.630 iki 3.413]; n = 52;... [toliau žr. visą tekstą]

There are many organisations trying to improve Diabetes Mellitus diagnostics, enhance glycaemia management of diabetes patients, because insufficient and late diagnosis increases formation, and complications progress. The purpose of this work was evolution of influence, of different methodological approaches to of glycated hemoglobin results. Samples of 100 patients with Diabetes Mellitus was analyzed for glucose and HbA1c. There was shown correlation between average concentration glucose‘s during three months coefficient. HbA1c was analyzed using three analytical systems of Roche-Hitachi 917, Bayer-Advia1650 and Dade Behring-Dimension RxL standardized according different standardization recommendations: International Federation of Clinical Chemistry and Laboratory Medicine (IFCC), Diabetes Control and Complications Trial (DCCT), National Glycohemoglobin Standardization Program (NGSP). Roche-Hitachi 917 results standardized according IFCC recommendations were chosen as reference. Correlation and differences between analytical systems were as follows. Roche-Hitachi 917 (IFCC) – Bayer-Advia1650 (NGSP): r = 1.017 [0.883 to 1.188]; y = 3.068 [1.894 to 4.142]; n = 52; p = 0.0000001. Roche-Hitachi 917 (DCCT) – Bayer-Advia1650 (NGSP): r = 1.132 [1.060 to 1.209]; y = 0.282 [-0.476 to 0.990]; n = 53; p = 0.001. Roche-Hitachi 917 (IFCC) – Dade Behring-Dimension RxL (DCCT): 0.886 [0.767 to 1.021]; y = 2.422 [1.630 to 3.413]; n = 52; p = 0.0000001. Roche-Hitachi 917 (DCCT) – Dade... [to full text]

Advisors/Committee Members: Vitkus, Dalius (Master's thesis supervisor).

Subjects/Keywords: Cukrinis Diabetas (Diabetes Mellitus); Glikozilintas hemoglobinas (glycated hemoglobin); Hemoglobinas A1c (hemoglobin A1c)

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Žilytė, Diana. (2014). Cukrinio diabeto monitoravimo laboratorinių rodiklių metodologinė analizė. (Masters Thesis). Vilnius University. Retrieved from http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2006~D_20140702_193728-67988 ;

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete

Chicago Manual of Style (16^th Edition):

Žilytė, Diana. “Cukrinio diabeto monitoravimo laboratorinių rodiklių metodologinė analizė.” 2014. Masters Thesis, Vilnius University. Accessed January 15, 2019. http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2006~D_20140702_193728-67988 ;.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete

MLA Handbook (7^th Edition):

Žilytė, Diana. “Cukrinio diabeto monitoravimo laboratorinių rodiklių metodologinė analizė.” 2014. Web. 15 Jan 2019.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete

Vancouver:

Žilytė, Diana. Cukrinio diabeto monitoravimo laboratorinių rodiklių metodologinė analizė. [Internet] [Masters thesis]. Vilnius University; 2014. [cited 2019 Jan 15]. Available from: http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2006~D_20140702_193728-67988 ;.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete

Council of Science Editors:

Žilytė, Diana. Cukrinio diabeto monitoravimo laboratorinių rodiklių metodologinė analizė. [Masters Thesis]. Vilnius University; 2014. Available from: http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2006~D_20140702_193728-67988 ;

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete

4. Di Pino, Antonino. Role of HbA1c in identify subjects with prediabetes and preclinical cardiovascular risk.

Degree: 2018, Università degli Studi di Catania

URL: http://hdl.handle.net/10761/3844

► Il prediabete è una condizione clinica caratterizzata da livelli di glucosio plasmatico superiori a quelli considerati normali, ma non così elevati da permettere la diagnosi… (more)

▼ Il prediabete è una condizione clinica caratterizzata da livelli di glucosio plasmatico superiori a quelli considerati normali, ma non così elevati da permettere la diagnosi di diabete mellito di tipo 2. Diversi studi clinici hanno più volte evidenziato come pazienti con prediabete presentino un incrementato rischio di sviluppare malattie cardiovascolari rispetto ai soggetti normoglicemici, indipendentemente da altri fattori di rischio. Sono definiti prediabetici i soggetti che rispondono ai seguenti criteri diagnostici: alterata glicemia a digiuno (impaired fasting glucose, IFG) e/o alterata glicemia dopo carico orale di glucosio (impaired glucose tolerance, IGT) e/o emoglobina glicata (HbA1c) compresa tra 5.7 e 6.4% (39-46 mmol/mol). Tuttavia, gli studi clinici hanno sempre mostrato che la concordanza tra i tre criteri diagnostici citati è scarsa e non esiste, ad oggi, un preciso consenso su quale di questi criteri sia il migliore predittore di malattia cardiovascolare. Lo scopo di questi progetti scientifici è stato valutare l abilità dell HbA1c nell identificare soggetti con prediabete ed alterazioni cardiovascolari precliniche che non sarebbero stati identificati con la glicemia a digiuno e dopo carico di glucosio. La produzione scientifica è stata quindi focalizzata sulla caratterizzazione del profilo di rischio cardiovascolare di soggetti con HbA1c nel range del prediabete (5.7-6.4%) ma con normale glicemia a digiuno e normale glicemia dopo carico di glucosio. In questa popolazione sono stati studiati marcatori di danno cardiovascolare precoce: spessore medio intimale carotideo; rigidità arteriosa; funzione diastolica cardiaca. Inoltre, sono stati indagati i livelli plasmatici di markers di infiammazione e glicazione strettamente legati con lo sviluppo di malattie cardiovascolari: Carbossi-metil-lisina; Recettore solubile degli AGEs (esRAGE); S100A12; 25(OH)D. I dati che abbiamo raccolto su questa popolazione, rispetto a soggetti di controllo non prediabetici, hanno messo in evidenza un alterazione di markers precoci di rischio cardiovascolare: aumento dello spessore medio intimale; aumento della rigidità arteriosa; alterazione della funzione diastolica cardiaca. Inoltre, questi soggetti presentavano alterazione di markers d infiammazione e glicazione strettamente connessi con il rischio cardiovascolare: bassi livelli di esRAGE; bassi livelli di 25(OH)D; alti livelli di S100A12; alti livelli di hs-CRP. Tali alterazioni erano inoltre strettamente correlate con i livelli di glicata della popolazione in studio. Dai dati esposti si evince la capacità dell HbA1c di identificare soggetti con alterazione del profilo di rischio cardiovascolare che non sarebbero stati identificati dalla glicemia a digiuno e dalla curva da carico di glucosio. Tali dati supportano l utilizzo dell HbA1c per la diagnosi di prediabete.

Subjects/Keywords: Area 06 - Scienze mediche; glycated hemoglobin, pre diabetes, cardiovascular risk

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Di Pino, A. (2018). Role of HbA1c in identify subjects with prediabetes and preclinical cardiovascular risk. (Thesis). Università degli Studi di Catania. Retrieved from http://hdl.handle.net/10761/3844

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Di Pino, Antonino. “Role of HbA1c in identify subjects with prediabetes and preclinical cardiovascular risk.” 2018. Thesis, Università degli Studi di Catania. Accessed January 15, 2019. http://hdl.handle.net/10761/3844.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Di Pino, Antonino. “Role of HbA1c in identify subjects with prediabetes and preclinical cardiovascular risk.” 2018. Web. 15 Jan 2019.

Vancouver:

Di Pino A. Role of HbA1c in identify subjects with prediabetes and preclinical cardiovascular risk. [Internet] [Thesis]. Università degli Studi di Catania; 2018. [cited 2019 Jan 15]. Available from: http://hdl.handle.net/10761/3844.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Di Pino A. Role of HbA1c in identify subjects with prediabetes and preclinical cardiovascular risk. [Thesis]. Università degli Studi di Catania; 2018. Available from: http://hdl.handle.net/10761/3844

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universidade do Rio Grande do Sul

5. Aguiar, Ana Paula Costa de. Aplicabilidade da estimativa da hemoglobina glicada a partir da albumina glicada em pacientes com diabetes mellitus tipo 2 e diferentes graus de comprometimento renal.

Degree: 2017, Universidade do Rio Grande do Sul

URL: http://hdl.handle.net/10183/157622

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O diabetes mellitus (DM) é uma doença crônica com alto índice de morbidade e mortalidade, sendo considerado um dos maiores problemas de saúde pública do… (more)

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O diabetes mellitus (DM) é uma doença crônica com alto índice de morbidade e mortalidade, sendo considerado um dos maiores problemas de saúde pública do século 21, afetando aproximadamente 415 milhões de pessoas. As complicações em longo prazo do DM incluem a doença renal, a qual pode levar à falência renal, a retinopatia com perda potencial da visão e neuropatia, bem como o risco de amputações. A hemoglobina glicada (A1c) é considerada o parâmetro de referência na avaliação do controle glicêmico de pacientes com DM. No entanto, a mensuração da A1c pode não ser adequada para avaliar as variações em curto prazo do controle glicêmico, devido ao longo tempo de vida dos eritrócitos (120 dias). Existem ainda algumas limitações do uso deste teste, como em pacientes com hemoglobinas variantes, persistência hereditária à hemoglobina fetal, anemia hemolítica, anemia renal, entre outros. A avaliação da glicação da albumina é considerada, por alguns autores, como um melhor marcador para o controle glicêmico do que a A1c, em situações onde a A1c é de difícil interpretação devido à presença de interferentes, uma vez que a glicação da albumina não é afetada pela alteração no tempo de sobrevida das hemácias, como ocorre com a A1c. Atualmente, não há nenhum teste de albumina glicada (AG) disponível na rotina prática no Brasil, sendo um método limitado à pesquisa. No entanto, vários estudos mostram dados promissores em relação à AG e o controle do DM em situações específicas. Assim, a AG tem sido considerada um marcador alternativo no controle glicêmico e há necessidade de maior investigação sobre a utilização deste teste na prática clínica.

Diabetes mellitus (DM) is a chronic disease with high morbidity and mortality, being considered one of the biggest public health problems of the 21st century, affecting approximately 415 million people. Long-term complications of DM include renal disease, which can lead to kidney failure, retinopathy with potential loss of vision and neuropathy, as well as the risk of amputations. Glycated hemoglobin (A1c) is considered the reference in the assessment of glycemic control in patients with diabetes mellitus (DM). However, A1c measurement may not be adequate to evaluate the short-term variations of glycemic control due to the long lifespan of erythrocytes (120 days). There are also some limitations of using this test, such as in patients with variant hemoglobins, hereditary persistence to fetal hemoglobin, hemolytic anemia, renal anemia, among others. The evaluation of albumin glycation is considered by some authors to be a better marker for glycemic control than A1c in situations where A1c is difficult to interpret due to the presence of interferents, since albumin glycation is not affected by alteration in the survival time of red blood cells, as occurs with A1c. Currently, there is no glycated albumin (GA) test available in routine practice in Brazil, being a method limited to the research. However, several studies show promising data about GA in DM control in specific situations. Therefore,…

Advisors/Committee Members: Camargo, Joiza Lins.

Subjects/Keywords: Glycated albumin; Diabetes mellitus; Hemoglobinas; Glycated hemoglobin; Insuficiência renal crônica; Diabetes mellitus; Albuminas; Chronic kidney disease

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Aguiar, A. P. C. d. (2017). Aplicabilidade da estimativa da hemoglobina glicada a partir da albumina glicada em pacientes com diabetes mellitus tipo 2 e diferentes graus de comprometimento renal. (Thesis). Universidade do Rio Grande do Sul. Retrieved from http://hdl.handle.net/10183/157622

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Aguiar, Ana Paula Costa de. “Aplicabilidade da estimativa da hemoglobina glicada a partir da albumina glicada em pacientes com diabetes mellitus tipo 2 e diferentes graus de comprometimento renal.” 2017. Thesis, Universidade do Rio Grande do Sul. Accessed January 15, 2019. http://hdl.handle.net/10183/157622.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Aguiar, Ana Paula Costa de. “Aplicabilidade da estimativa da hemoglobina glicada a partir da albumina glicada em pacientes com diabetes mellitus tipo 2 e diferentes graus de comprometimento renal.” 2017. Web. 15 Jan 2019.

Vancouver:

Aguiar APCd. Aplicabilidade da estimativa da hemoglobina glicada a partir da albumina glicada em pacientes com diabetes mellitus tipo 2 e diferentes graus de comprometimento renal. [Internet] [Thesis]. Universidade do Rio Grande do Sul; 2017. [cited 2019 Jan 15]. Available from: http://hdl.handle.net/10183/157622.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Aguiar APCd. Aplicabilidade da estimativa da hemoglobina glicada a partir da albumina glicada em pacientes com diabetes mellitus tipo 2 e diferentes graus de comprometimento renal. [Thesis]. Universidade do Rio Grande do Sul; 2017. Available from: http://hdl.handle.net/10183/157622

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universidade do Rio Grande do Sul

6. Greggianin, Bruna Frizon. Efeito do tratamento periodontal nos parâmetros metabólicos e pressão arterial de pacientes portadores de síndrome metabólica : análise parcial de um ensaio clínico randomizado.

Degree: 2016, Universidade do Rio Grande do Sul

URL: http://hdl.handle.net/10183/142160

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A Síndrome Metabólica (SM) é uma condição de prevalência crescente no mundo e existe pouca informação sobre o efeito do tratamento periodontal nos parâmetros metabólicos… (more)

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A Síndrome Metabólica (SM) é uma condição de prevalência crescente no mundo e existe pouca informação sobre o efeito do tratamento periodontal nos parâmetros metabólicos em pacientes com SM. O objetivo desta tese é comparar o efeito do tratamento periodontal nos níveis de hemoglobina glicada, glicose em jejum, triglicerídeos, colesterol HDL, colesterol total, insulina, resistência à insulina, função de células beta, proteína C reativa (PCR) e pressão arterial (PA) em pacientes com periodontite e SM em um período de 6 meses. Metodologia/ Desenho: Esta tese compreende uma análise parcial de um ensaio clínico randomizado com indivíduos com diagnóstico concomitante de periodontite _ ≥ 2 sítios interproximais com perda de inserção (PI) ≥4 mm ou ≥2 sítios interproximal com profundidade de sondagem (PS) ≥ 5mm em dentes não-adjacentes e não no mesmo dente e SM (Federação Internacional do Diabetes-2009). Setenta e dois indivíduos foram randomizados para grupo teste (tratamento periodontal imediato) ou controle (tratamento periodontal tardio-após 6 meses). Os pacientes receberam avaliação odontológica e realizaram exames sanguíneos nos tempos inicial, 3 e 6 meses, além de tratamento médico para hiperglicemia, dislipidemia e hipertensão quando necessário. O desfecho primário foi alteração na hemoglobina glicada e os desfechos secundários foram alterações na glicose, triglicerídeos, colesterol total e HDL, insulina, resistência à insulina, função de células beta, PCR e PA. A análise estatística foi realizada utilizando o modelo de Equações de Estimações Generalizadas (GEE: Generalized Estimating Equations). Resultados: Não houveram diferenças significativas nos parâmetros periodontais e metabólicos em ambos os grupos no exame inicial. Houve redução significativa de placa, sangramento marginal, fatores retentivos de placa, sangramento subgengival, média de PS e de PI no grupo teste. Não houve diferença significativa nos parâmetros metabólicos e na pressão arterial aos 3 e 6 meses comparando-se indivíduos que receberam tratamento periodontal ou não. Na análise intra-grupo, indivíduos do grupo controle reduziram os níveis de insulina e resistência à insulina e aumentaram colesterol HDL aos 3 e 6 meses. Na análise do percentil 75º de hemoglobina glicada e de sangramento subgengival, a comparação intra-grupo mostrou redução significativa de hemoglobina glicada no grupo teste dos 3 para os 6 meses, além de melhora no grupo controle de insulina, resistência à insulina e HDL. Conclusão: A despeito da melhora nos parâmetros periodontais no grupo teste, não houve efeito do tratamento periodontal nos parâmetros metabólicos e na PA.

Metabolic syndrome (MS) is a condition of increasing prevalence in the world and there is a little information on the effect of periodontal treatment on levels of metabolic parameters in patients with MS. The objective of this thesis is to compare the effect of periodontal treatment on levels of glycated hemoglobin, fasting glucose, triglycerides, HDL cholesterol, total cholesterol, insulin, insulin…

Advisors/Committee Members: Oppermann, Rui Vicente.

Subjects/Keywords: Metabolic syndrome; Periodontite; Síndrome X metabólica; Periodontitis; Non-surgical periodontal treatment; Glycated hemoglobin

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Greggianin, B. F. (2016). Efeito do tratamento periodontal nos parâmetros metabólicos e pressão arterial de pacientes portadores de síndrome metabólica : análise parcial de um ensaio clínico randomizado. (Thesis). Universidade do Rio Grande do Sul. Retrieved from http://hdl.handle.net/10183/142160

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Greggianin, Bruna Frizon. “Efeito do tratamento periodontal nos parâmetros metabólicos e pressão arterial de pacientes portadores de síndrome metabólica : análise parcial de um ensaio clínico randomizado.” 2016. Thesis, Universidade do Rio Grande do Sul. Accessed January 15, 2019. http://hdl.handle.net/10183/142160.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Greggianin, Bruna Frizon. “Efeito do tratamento periodontal nos parâmetros metabólicos e pressão arterial de pacientes portadores de síndrome metabólica : análise parcial de um ensaio clínico randomizado.” 2016. Web. 15 Jan 2019.

Vancouver:

Greggianin BF. Efeito do tratamento periodontal nos parâmetros metabólicos e pressão arterial de pacientes portadores de síndrome metabólica : análise parcial de um ensaio clínico randomizado. [Internet] [Thesis]. Universidade do Rio Grande do Sul; 2016. [cited 2019 Jan 15]. Available from: http://hdl.handle.net/10183/142160.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Greggianin BF. Efeito do tratamento periodontal nos parâmetros metabólicos e pressão arterial de pacientes portadores de síndrome metabólica : análise parcial de um ensaio clínico randomizado. [Thesis]. Universidade do Rio Grande do Sul; 2016. Available from: http://hdl.handle.net/10183/142160

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universidade do Rio Grande do Sul

7. Spessatto, Débora. Associação dos níveis de HbA1c com colesterol LDL e colesterol LDL oxidado em indivíduos não-diabéticos.

Degree: 2011, Universidade do Rio Grande do Sul

URL: http://hdl.handle.net/10183/39649

► Introdução: O Diabetes mellitus (DM) está associado a complicações crônicas micro e macrovasculares. A medida da hemoglobina glicada (HbA1c) avalia o grau do controle glicêmico… (more)

▼ Introdução: O Diabetes mellitus (DM) está associado a complicações crônicas micro e macrovasculares. A medida da hemoglobina glicada (HbA1c) avalia o grau do controle glicêmico em pacientes diabéticos e seus níveis são capazes de prognosticar o risco de desenvolvimento dessas complicações. Entre as origens das complicações causadas pela hiperglicemia, há a hipótese dos produtos finais de glicação avançada (AGEs) e do estresse oxidativo. A reação de glicação não enzimática das proteínas também está relacionada com as complicações diabéticas e é responsável pela formação da HbA1c. Entretanto, tem sido demonstrado um aumento dessa glicação em pacientes não diabéticos. Um dos prováveis mecanismos para esse aumento é a peroxidação lipídica, com conseqüente aumento nos níveis de malondialdeído (MDA) que modifica a apolipoproteína B (APO B) do colesterol de baixa densidade (LDL). A modificação oxidativa do LDL confere propriedades específicas pró-aterogênicas. A presença do LDL oxidado e o aumento da tendência do LDL à peroxidação lipídica, podem contribuir para o aumento dos níveis de HbA1c. Objetivo: Verificar a associação entre os níveis de HbA1c com o Colesterol LDL e LDL oxidado em Indivíduos não-diabéticos. Métodos: Foi realizado um estudo transversal observacional, no qual um total de 196 indivíduos, classificados como não-diabéticos, foram analisados e divididos em três grupos, conforme os valores de HbA1c e glicemia de jejum (GJ): Grupo 1 (n =64) - HbA1c <5,7% e GJ <100 mg/dL; Grupo 2 (n =69) - HbA1c ≥5,7 e ≤6,4% e GJ <100 mg/dL; Grupo 3 (n =63) - HbA1c ≥5,7 e ≤6,4% e GJ ≥100 e <126mg/dL. Amostras de sangue total e soro foram coletadas. O LDL oxidado foi medido por método imunoensaio enzimático (Mercodia ®), ApoB dosada por imunoturbidimentria, a relação Colesterol LDL(oxi)/Colesterol-HDL foi estimada, além das outras dosagens bioquímicas do perfil lipídico. Esses testes foram comparados e analisados entre os três diferentes grupos. Resultados: Houve diferença significativa nos níveis de LDL(oxi) (p< 0,001), Apo B (p= 0,026) e razão LDL(oxi)/HDL (p< 0,001) entre os três grupos. Os valores de HbA1c apresentaram correlação positiva com os valores de LDL (oxi) (r =0,431; p <0,001), LDL (r =0,148; p =0,039), Col Não-HDL (r =0,192; p =0,007) e Apo B (r =0,171; p <0,001). Estas associações positivas permaneceram significativas, mesmo após ajuste, por análise de regressão linear múltipla para as variáveis álcool, medicamentos, índice de massa corporal (IMC) e idade. Também apresentaram correlações positivas com os valores de HbA1c: razão LDL (oxi)/HDL (r =0,422; p <0,001), CT (r =0,142; p =0,048), triglicerídios (r =0,155; p =0,030) e IMC (r =0,263; p <0,001). Conclusão: Nosso estudo demonstrou associação dos níveis de HbA1c com as partículas lipídicas aterogênicas LDL, Apo B, colesterol não HDL e LDL (oxi). Os níveis de LDL, principalmente LDL (oxi), estão significativamente associados com os níveis de HbA1c e glicose, mesmo em indivíduos não-diabéticos. Os indivíduos classificados com alto risco de desenvolver DM ou… Advisors/Committee Members: Camargo, Joiza Lins.

Subjects/Keywords: HDL-colesterol; Diabetes mellitus; LDL-colesterol; Glycated hemoglobin; Oxidized cholesterol LDL; Hemoglobina A glicosilada

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Spessatto, D. (2011). Associação dos níveis de HbA1c com colesterol LDL e colesterol LDL oxidado em indivíduos não-diabéticos. (Thesis). Universidade do Rio Grande do Sul. Retrieved from http://hdl.handle.net/10183/39649

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Spessatto, Débora. “Associação dos níveis de HbA1c com colesterol LDL e colesterol LDL oxidado em indivíduos não-diabéticos.” 2011. Thesis, Universidade do Rio Grande do Sul. Accessed January 15, 2019. http://hdl.handle.net/10183/39649.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Spessatto, Débora. “Associação dos níveis de HbA1c com colesterol LDL e colesterol LDL oxidado em indivíduos não-diabéticos.” 2011. Web. 15 Jan 2019.

Vancouver:

Spessatto D. Associação dos níveis de HbA1c com colesterol LDL e colesterol LDL oxidado em indivíduos não-diabéticos. [Internet] [Thesis]. Universidade do Rio Grande do Sul; 2011. [cited 2019 Jan 15]. Available from: http://hdl.handle.net/10183/39649.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Spessatto D. Associação dos níveis de HbA1c com colesterol LDL e colesterol LDL oxidado em indivíduos não-diabéticos. [Thesis]. Universidade do Rio Grande do Sul; 2011. Available from: http://hdl.handle.net/10183/39649

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Texas – Austin

8. Owusu, Yaw Boahene. Incident coronary atherosclerosis, unstable angina, non-ST-segment elevation myocardial infarction or ST-segment elevation myocardial infarction in type 2 diabetes : is mean glycated hemoglobin a good predictor?.

Degree: Pharmacy, 2010, University of Texas – Austin

URL: http://hdl.handle.net/2152/ETD-UT-2010-12-2067

► Background: Glycated hemoglobin is the indicator of long-term diabetes control and a value below 7 percent is recommended by the American Diabetes Association (ADA) to… (more)

▼ Background: Glycated hemoglobin is the indicator of long-term diabetes control and a value below 7 percent is recommended by the American Diabetes Association (ADA) to reduce cardiovascular complications. Diabetic patients have a two- to four-fold risk of cardiovascular disease and approximately two-thirds of diabetic patients die as a result of cardiovascular complications. Three large prospective randomized controlled long-term trials within the last decade reported no significant reduction in cardiovascular complications in type 2 diabetic patients by intensive glycemic control. To the author's knowledge, no known retrospective studies have examined the association between mean serial glycated hemoglobin and coronary atherosclerosis (CA) or acute coronary syndromes (ACS). Objective: This study was designed to determine the association between mean serial glycated hemoglobin with incident CA or ACS in type 2 diabetic patients after controlling for age, gender, hypertension, low density lipoprotein cholesterol (LDL-C), microalbuminuria, aspirin use, statin use, insulin use, tobacco use, and body mass index (BMI). Methods: The study was a retrospective cohort database analysis using the Austin Travis County CommUnityCare[trademark] clinics' electronic medical record for the time period between October 1, 2004 and September 30, 2009. The primary outcome of the study was the incidence of CA or ACS and the primary independent variable was glycated hemoglobin (<7% vs. [greater than or equal to]7%). The study subjects included type 2 diabetic patients aged 30 to 80 years with at least one glycated hemoglobin value per year for a minimum of two consecutive years. Study subjects were excluded if CA or ACS occurred within six months of the index date (i.e., first glycated hemoglobin). Logistic regression analysis was used to address the study objective. Results: Overall, 3069 subjects met the study inclusion criteria with a mean follow-up period of approximately two years. Two percent (N=62) of the subjects had incident CA or ACS. After controlling for age, gender, hypertension diagnosis, LDL-C, microalbuminuria, aspirin use, statin use, insulin use, tobacco use and BMI, there was no significant association (OR=1.026, 95% CI=0.589-1.785, p=0.9289) between mean serial glycated hemoglobin and the incident diagnosis of CA or ACS. Increasing age (OR=1.051, 95% CI=1.025-1.077, p<0.0001), male gender (OR=1.855, 95% CI=1.105-3.115, p=0.0195) and normal weight (normal or underweight compared to obese: OR=0.122, 95% CI=0.017-0.895, p=0.0438) were significantly associated with incident CA or ACS. Conclusions: Mean serial glycated hemoglobin (comparing [greater than or equal to]7% to <7%) was not significantly associated with CA or ACS over a mean follow-up period of approximately two years. Until more evidence becomes available, clinicians and diabetic patients should target glycated hemoglobin level below or close to 7 percent as recommended by the ADA soon after diagnosis while concomitantly controlling nonglycemic risk factors of… Advisors/Committee Members: Lawson, Kenneth Allen, 1952- (advisor), Barner, Jamie C. (advisor), Jokerst, Jason R. (committee member), Lopez, Debra (committee member).

Subjects/Keywords: Diabetes; Acute coronary syndromes; Coronary atherosclerosis; Glycated hemoglobin; Diagnosis; Type 2 diabetes

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Owusu, Y. B. (2010). Incident coronary atherosclerosis, unstable angina, non-ST-segment elevation myocardial infarction or ST-segment elevation myocardial infarction in type 2 diabetes : is mean glycated hemoglobin a good predictor?. (Thesis). University of Texas – Austin. Retrieved from http://hdl.handle.net/2152/ETD-UT-2010-12-2067

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Owusu, Yaw Boahene. “Incident coronary atherosclerosis, unstable angina, non-ST-segment elevation myocardial infarction or ST-segment elevation myocardial infarction in type 2 diabetes : is mean glycated hemoglobin a good predictor?.” 2010. Thesis, University of Texas – Austin. Accessed January 15, 2019. http://hdl.handle.net/2152/ETD-UT-2010-12-2067.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Owusu, Yaw Boahene. “Incident coronary atherosclerosis, unstable angina, non-ST-segment elevation myocardial infarction or ST-segment elevation myocardial infarction in type 2 diabetes : is mean glycated hemoglobin a good predictor?.” 2010. Web. 15 Jan 2019.

Vancouver:

Owusu YB. Incident coronary atherosclerosis, unstable angina, non-ST-segment elevation myocardial infarction or ST-segment elevation myocardial infarction in type 2 diabetes : is mean glycated hemoglobin a good predictor?. [Internet] [Thesis]. University of Texas – Austin; 2010. [cited 2019 Jan 15]. Available from: http://hdl.handle.net/2152/ETD-UT-2010-12-2067.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Owusu YB. Incident coronary atherosclerosis, unstable angina, non-ST-segment elevation myocardial infarction or ST-segment elevation myocardial infarction in type 2 diabetes : is mean glycated hemoglobin a good predictor?. [Thesis]. University of Texas – Austin; 2010. Available from: http://hdl.handle.net/2152/ETD-UT-2010-12-2067

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

9. Féron, Delphine. Significations physiopathologiques des hémorphines de type 7 dans le diabète et les cancers broncho-pulmonaires : Physiopathological significations of hemorphin-7 in diabetes and lung cancers.

Degree: Docteur es, Biochimie, 2010, La Rochelle

URL: http://www.theses.fr/2010LAROS293

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Les hémorphines représentent une classe de peptides cryptiques bioactifs issus de la protéolyse de la chaîne ß de l’hémoglobine dont la présence in vivo a… (more)

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Les hémorphines représentent une classe de peptides cryptiques bioactifs issus de la protéolyse de la chaîne ß de l’hémoglobine dont la présence in vivo a souvent été associée à des conditions physiologiques ou pathologiques particulières, comme les cancers. De ce fait, l’hypothèse d’utiliser ces peptides comme marqueur de pathologies avaient déjà été posé. Des études récentes au laboratoire ont montré que leur concentration sérique des hémorphines était diminuée chez les patients diabétiques. Nous avons travaillé sur une cohorte de 120 patients atteints de diabète de type 1 et 2 et nous avons étudié les différentes hypothèses permettant d’expliquer cette diminution : métabolisme des hémorphines, impact de la glycation de l’hémoglobine sur la libération des peptides. De plus, nous avons cherché à connaître le rôle de LVVH7 dans la signalisation insulinique. Les résultats obtenus suggèrent que la diminution de la concentration sérique des hémorphines de type 7 est spécifique du diabète mais que la glycation de l’hémoglobine n’a pas d’impact sur la libération des hémorphines. Parallèlement à cette étude, nous avons caractérisé les hémorphines de type 7 dans le microenvironnement du cancer broncho-pulmonaire. La cathepsine D, enzyme impliquée dans la libération de LVVH7 et VVH7 ainsi que dans le microenvironnement tumoral, a été étudié dans des cultures de lignées de cancers broncho-pulmonaires acidifiée et donc propice à la progression tumorale. Les résultats ont permis de confirmer la présence de la cathepsine D dans le surnageant de cultures des cellules cancéreuses. De plus, nous avons montré la libération d’hémorphines de type 7 dans des milieux de culture acidifiés.

Hemorphins are cryptic bioactive peptides derived from ß chain of haemoglobin proteolysis. Their biological presence has often been associated with physiological or pathological conditions, like cancers. Thus, it was already suggested that hemorphins could be used as marker of pathology. Previous studies achieved in our laboratory demonstrated that hemorphin-7 was decreased in serum of diabetic patients. We worked on a population of 120 patients with type 1 and type 2 diabetes and we studied different hypothesis: hemorphins metabolism, impact of glycated haemoglobin. Moreover, we researched the role of LVVH7 in insulin signalisation. The results suggested that hemorphin-7 concentrations in serum of diabetic patients are specific of this pathology but glycation of haemoglobin have no impact on liberation of hemorphins. In parallel, we characterized hemorphin-7 in tumor progression of lung cancers. Cathepsin D, previously demonstrated as a key enzyme in hemorphins generation and also in tumor progression, has been studied in vitro in lung cancers, cultured in acidified conditions, favourable to metastasis. In addition, we also identified hemorphin-7 liberation in acidified media culture.

Advisors/Committee Members: Piot, Jean-Marie (thesis director), Fruitier-Arnaudin, Ingrid (thesis director).

Subjects/Keywords: Hémorphines; Diabète; Cancer broncho-pulmonaire; Cathepsine D; Hémoglobine glyquée; Hemorphins; Diabetes; Lung cancer; Cathepsin D; Glycated hemoglobin

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Féron, D. (2010). Significations physiopathologiques des hémorphines de type 7 dans le diabète et les cancers broncho-pulmonaires : Physiopathological significations of hemorphin-7 in diabetes and lung cancers. (Doctoral Dissertation). La Rochelle. Retrieved from http://www.theses.fr/2010LAROS293

Chicago Manual of Style (16^th Edition):

Féron, Delphine. “Significations physiopathologiques des hémorphines de type 7 dans le diabète et les cancers broncho-pulmonaires : Physiopathological significations of hemorphin-7 in diabetes and lung cancers.” 2010. Doctoral Dissertation, La Rochelle. Accessed January 15, 2019. http://www.theses.fr/2010LAROS293.

MLA Handbook (7^th Edition):

Féron, Delphine. “Significations physiopathologiques des hémorphines de type 7 dans le diabète et les cancers broncho-pulmonaires : Physiopathological significations of hemorphin-7 in diabetes and lung cancers.” 2010. Web. 15 Jan 2019.

Vancouver:

Féron D. Significations physiopathologiques des hémorphines de type 7 dans le diabète et les cancers broncho-pulmonaires : Physiopathological significations of hemorphin-7 in diabetes and lung cancers. [Internet] [Doctoral dissertation]. La Rochelle; 2010. [cited 2019 Jan 15]. Available from: http://www.theses.fr/2010LAROS293.

Council of Science Editors:

Féron D. Significations physiopathologiques des hémorphines de type 7 dans le diabète et les cancers broncho-pulmonaires : Physiopathological significations of hemorphin-7 in diabetes and lung cancers. [Doctoral Dissertation]. La Rochelle; 2010. Available from: http://www.theses.fr/2010LAROS293

Universidade do Estado do Rio de Janeiro

10. Viviane Monteiro Dias. Utilização do método de contagem de carboidratos no controle glicêmico em diabéticos tipo 1.

Degree: Master, 2009, Universidade do Estado do Rio de Janeiro

URL: http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=1500 ;

►

Segundo a American Diabetes Association, é importante a ênfase no controle glicêmico com o objetivo de prevenir complicações microvasculares em diabéticos, e a adoção de… (more)

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Segundo a American Diabetes Association, é importante a ênfase no controle glicêmico com o objetivo de prevenir complicações microvasculares em diabéticos, e a adoção de um plano alimentar saudável é fundamental no tratamento destes pacientes. O método de contagem de carboidratos é uma estratégia nutricional, é um método usado por indivíduos diabéticos, que associa o total de carboidratos ingerido nas refeições com a dose de insulina utilizada, com o objetivo de manter a glicemia dentro dos limites convenientes. O objetivo desse estudo foi avaliar se a intervenção nutricional, utilizando o método de contagem de carboidratos, influencia o controle glicêmico de pacientes com diabetes mellitus tipo 1 (DM1). Foram avaliados 157 DM1, 96 constituíram o grupo intervenção com dieta prescrita e com o uso do método de contagem de carboidratos e 61 pacientes DM1 constituíram o grupo controle com dieta prescrita e sem contagem de carboidratos. Os diabéticos foram monitorados por um período de seis meses. Na primeira visita foram submetidos a um questionário de caracterização dos indivíduos, avaliação antropométrica, bioquímica, clínica e dietética. Houve diferença significativa entre o registro alimentar preenchido durante 3 dias e a dieta prescrita, nos gramas de proteína consumidos por dia 50,39 + 29,27 e 22,01 + 3,05 (p= 0,02), como também no índice glicêmico (IG) do almoço 43,00 + 24,89 e 7,83 + 1,88 (p=0,02), e do jantar 50,09 + 35,09 e 7,56 + 2,57 (p=0,00). Em relação a avaliação antropométrica houve aumento não significativo em ambos os grupos, no Índice de Massa Corporal calculado e nos parâmetros antropométricos (circunferência abdominal, circunferência de quadril e relação cintura-quadril). Na avaliação dos parâmetros bioquímicos, observa-se diminuição significativa, somente no grupo intervenção, da hemoglobina glicada (A1C) de 9,8 + 2,26 para 9,1 + 2,16 (p= 0,023) após 6 meses. As correlações entre os dados antropométricos e a A1C, e entre os diferentes tipos de ácidos graxos da dieta proposta e parâmetros bioquímicos colesterol, triglicerídeos, HDLc e LDLc plasmáticos foram consideradas de baixa intensidade. Diante dos resultados concluiu-se que a intervenção por meio do método de contagem de carboidratos proporcionou uma melhora significativa no controle glicêmico dos pacientes estudados.

According to the American Diabetes Association, is important to focus on glycemic control in order to prevent microvascular complications in patients with type 1 diabetes, and the adoption of a plan healthy food is crucial in treating these patients. The method of carbohydrate counting is a nutritional strategy, it is a method used by diabetic individuals, which combines the total carbohydrate intake at meals with the dose of insulin used, with the goal of maintaining blood glucose within the limits appropriate. The aim of this study was to assess whether the nutrition intervention, using the method of carbohydrate couting, influences the glycemic control of patients with diabetes mellitus type 1 (DM1). We evaluated 157 DM1, 96…

Advisors/Committee Members: Marilia de Brito Gomes, Eliane de Abreu Soares, Luciana Diniz Carneiro Spina, Henyse Gomes Valente da Silva.

Subjects/Keywords: Type 1 diabetes; Controle glicêmico; Hemoglobina glicada; Contagem de carboidratos; NUTRICAO; Diabetes mellitus tipo 1; Carbohydrate counting; Glycated hemoglobin; Glycemic control

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Dias, V. M. (2009). Utilização do método de contagem de carboidratos no controle glicêmico em diabéticos tipo 1. (Masters Thesis). Universidade do Estado do Rio de Janeiro. Retrieved from http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=1500 ;

Chicago Manual of Style (16^th Edition):

Dias, Viviane Monteiro. “Utilização do método de contagem de carboidratos no controle glicêmico em diabéticos tipo 1.” 2009. Masters Thesis, Universidade do Estado do Rio de Janeiro. Accessed January 15, 2019. http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=1500 ;.

MLA Handbook (7^th Edition):

Dias, Viviane Monteiro. “Utilização do método de contagem de carboidratos no controle glicêmico em diabéticos tipo 1.” 2009. Web. 15 Jan 2019.

Vancouver:

Dias VM. Utilização do método de contagem de carboidratos no controle glicêmico em diabéticos tipo 1. [Internet] [Masters thesis]. Universidade do Estado do Rio de Janeiro; 2009. [cited 2019 Jan 15]. Available from: http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=1500 ;.

Council of Science Editors:

Dias VM. Utilização do método de contagem de carboidratos no controle glicêmico em diabéticos tipo 1. [Masters Thesis]. Universidade do Estado do Rio de Janeiro; 2009. Available from: http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=1500 ;

Universidade do Rio Grande do Sul

11. Bgeginski, Roberta. Efeito do exercício físico no tratamento de gestantes disgnosticadas com diabetes mellitus gestacional.

Degree: 2015, Universidade do Rio Grande do Sul

URL: http://hdl.handle.net/10183/139751

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Introdução: O exercício físico como parte do tratamento do diabetes mellitus gestacional (DMG) pode ajudar na manutenção das concentrações da glicemia de jejum. Objetivos: Conduzir… (more)

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Introdução: O exercício físico como parte do tratamento do diabetes mellitus gestacional (DMG) pode ajudar na manutenção das concentrações da glicemia de jejum. Objetivos: Conduzir uma revisão sistemática, com metanálise de ensaios clínicos randomizados, para avaliar o efeito do exercício supervisionado e estruturado ou o efeito do aconselhamento de atividade física, em mulheres com DMG, e comparar ao pré-natal usual para o controle da glicemia. Métodos: Os estudos elegíveis foram identificados a partir das bases de dados MEDLINE, EMBASE, Web of Science, Scopus e SportDiscus até 4 de Junho de 2015. Os dados foram extraídos de ensaios clínicos randomizados que compararam o pré-natal usual ao pré-natal usual somado ao exercício supervisionado e estruturado (pelo menos uma vez na semana) ou ao aconselhamento de atividade física, pelas quais os valores de glicemia de jejum pré e pós-intervenção estavam disponíveis. A metanálise de efeitos randômicos foi conduzida para a diferença entre as médias pós-intervenção da glicemia de jejum. Resultados: Foram encontradas 664 publicações, nas quais 82 foram avaliadas pela elegibilidade e oito foram incluídas na análise final. O efeito total do exercício nas concentrações absolutas da glicemia de jejum não foi significativamente diferente (P = 0,11) comparado ao pré-natal usual. Entretanto, o aconselhamento de atividade física comparado ao pré-natal usual demonstrou uma redução significativa nas concentrações da glicemia de jejum (diferença da média ponderada -3,88 mg/dL, 95% CI-7,33 a -0,42; I2, 48%; P para heterogeneidade < 0,15). Conclusão: O exercício supervisionado ou o aconselhamento de atividade física em mulheres com DMG não foi significativamente diferente comparado ao pré-natal usual nas concentrações de glicemia de jejum. Visto que o pré-natal usual inclui algum tipo de recomendação de atividade física, estes resultados não são surpreendentes. O aconselhamento de atividade física com o pré-natal usual inclui modificações da dieta que podem motivar as mulheres com DMG a serem mais ativas e aderentes ao aconselhamento nutricional, enquanto que o exercício estruturado pode ser mais difícil de atingir.

Background: Exercise as part of the treatment for gestational diabetes mellitus (GDM) may help maintain fasting glucose concentrations. Objective: A systematic review with meta-analysis was performed to evaluate the effect of weekly-supervised exercise or physical activity (PA) counseling in GDM women compared to standard care (SC) on glycemic control. Methods: Eligible trials were identified from MEDLINE, EMBASE, Web of Science, Scopus and SportDiscus up to 4 June 2015. Data were retrieved from randomized controlled trials comparing SC with SC plus weekly-supervised (at least once a week) prenatal exercise or PA counseling for which fasting blood glucose (FBG) values pre and post intervention were available. Random-effects meta-analysis was conducted for mean difference in FBG post exercise intervention. Results: Our search yielded 664 publications of which 82 were…

Advisors/Committee Members: Ramos, José Geraldo Lopes.

Subjects/Keywords: Pregnancy; Gravidez; Exercício; Gestational diabetes mellitus; Physical exercise; Diabetes gestacional; Blood glucose, Insulin; Insulin; Glycated hemoglobin

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Bgeginski, R. (2015). Efeito do exercício físico no tratamento de gestantes disgnosticadas com diabetes mellitus gestacional. (Thesis). Universidade do Rio Grande do Sul. Retrieved from http://hdl.handle.net/10183/139751

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Bgeginski, Roberta. “Efeito do exercício físico no tratamento de gestantes disgnosticadas com diabetes mellitus gestacional.” 2015. Thesis, Universidade do Rio Grande do Sul. Accessed January 15, 2019. http://hdl.handle.net/10183/139751.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Bgeginski, Roberta. “Efeito do exercício físico no tratamento de gestantes disgnosticadas com diabetes mellitus gestacional.” 2015. Web. 15 Jan 2019.

Vancouver:

Bgeginski R. Efeito do exercício físico no tratamento de gestantes disgnosticadas com diabetes mellitus gestacional. [Internet] [Thesis]. Universidade do Rio Grande do Sul; 2015. [cited 2019 Jan 15]. Available from: http://hdl.handle.net/10183/139751.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Bgeginski R. Efeito do exercício físico no tratamento de gestantes disgnosticadas com diabetes mellitus gestacional. [Thesis]. Universidade do Rio Grande do Sul; 2015. Available from: http://hdl.handle.net/10183/139751

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

12. Francisca Adilfa de Oliveira Garcia. Estudo dos PossÃveis Mecanismos da AÃÃo Hipoglicemiante da Pentoxifilina no Modelo de Diabetes Mellitus Induzido por Aloxano em Ratos.

Degree: PhD, 2012, Universidade Federal do Ceará

URL: http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=10526 ;

► A pentoxifilina (PTX) Ã um inibidor nÃo-seletivo da fosfodiesterase, com aÃÃes antiinflamatÃrias vasculares e reolÃgicas que podem neutralizar algumas das mudanÃas no diabetes mellitus (DM)… (more)

▼ A pentoxifilina (PTX) Ã um inibidor nÃo-seletivo da fosfodiesterase, com aÃÃes antiinflamatÃrias vasculares e reolÃgicas que podem neutralizar algumas das mudanÃas no diabetes mellitus (DM) que contribuem para amenizar os seus efeitos secundÃrios como a neuropatia, a retinopatia e a nefropatia. Tendo em vista as propriedades antiinflamatÃrias da pentoxifilina e o envolvimento da inflamaÃÃo com o DM, buscou-se investigar seus possÃveis efeitos hipoglicemiante e hipolipemiante no modelo de DM induzido por aloxano em ratos. A pentoxifilina (PTX) em estudos pilotos apresentou efeito hipoglicemiante e reduziu os nÃveis de triglicerÃdeos em animais com diabetes induzidos por aloxano, nas doses 5, 25, 50 e 100 mg/Kg. A administraÃÃo oral da associaÃÃo de pentoxifilina (PTX) com glibenclamida (GLI), PTX5 + GLI2, causou reduÃÃes significativas nos nÃveis plasmÃticos de glicose e triglicerÃdeos em curto e longo prazo, evidenciando que o mecanismo de aÃÃo da PTX pode ser explicado via canais de K+ATP-dependentes. A administraÃÃo oral da associaÃÃo de Pentoxifilina (PTX) com Metformina (MET), PTX5 + MET5, ocasionou uma reduÃÃo da hiperglicemia apenas a longo prazo, sugerindo nÃo compartilharem o mesmo mecanismo. A PTX nÃo bloqueou a hiperglicemia induzida pelo Diazoxido (DZD), um antagonista da GLI, que inibe a secreÃÃo de insulina prolongando o tempo de abertura dos canais de K+ATP-dependentes, sugerindo que outros fatores, alÃm do bloqueio de canais de K+-ATP dependentes, podem estar envolvidos. A reduÃÃo nos valores de hemoglobina glicada (A1C) e de frutosamina mostraram que o tratamento com PTX50 e com a associaÃÃo PTX5+GLI2 melhorou o controle glicÃmico dos animais em estudo, indicando que esta droga pode inibir o desenvolvimento de lesÃes micro e macrovasculares advindas do DM. A PTX mostrou um marcante efeito antiinflamatÃrio, melhorando o estado geral dos ratos em experimentaÃÃo. Reduziu, de forma significativa, o edema de pata nas doses de 50 e 100 mg/Kg, todavia foi visto que o perfil inflamatÃrio no rato diabÃtico tem um padrÃo diferenciado do rato normal, evidenciando uma amplificaÃÃo do processo inflamatÃrio no rato diabÃtico quando comparado ao rato normal. Foi visto ainda que os nÃveis de TNF-∝ e IL-6 aumentaram de modo significante apÃs a induÃÃo do edema de pata nos ratos diabÃticos, entretanto nos ratos tratados com PTX os nÃveis teciduais destas citocinas mostraram-se significativamente mais baixos, o que fala a favor de uma evidente aÃÃo antiinflamatÃria da PTX. A PTX mostrou tambÃm um importante efeito antioxidante reduzindo, de forma significativa, as liberaÃÃes de nitrito tecidual e sÃrica, atuando favoravelmente na reduÃÃo de radicais livres. O tratamento prolongado com PTX foi eficaz em manter o padrÃo normal do pÃncreas, do fÃgado e dos rins nos grupos diabÃticos tratados com PTX50 e com PTX5+GLI2, indicando uma aÃÃo protetora da PTX contra a citotoxicidade induzida pelo aloxano. Os efeitos hipoglicemiante e hipotrigliceridÃmico da PTX, aqui demonstrados, podem estÃ correlacionado com sua aÃÃo… Advisors/Committee Members: Glauce Socorro de Barros Viana, CÃcero Francisco Bezerra Felipe, Maria Goretti Rodrigues de Queiroz, AntÃnio JosÃ Lapa, Renan MagalhÃes Montenegro JÃnior.

Subjects/Keywords: FARMACOLOGIA; Pentoxifilina; InflamaÃÃo; Hemoglobina A Glicosilada; DiazÃxido; Citocinas; pentoxifylline; glibenclamide; anti-inflammatory; glycated hemoglobin; diazoxide; cytokines

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Garcia, F. A. d. O. (2012). Estudo dos PossÃveis Mecanismos da AÃÃo Hipoglicemiante da Pentoxifilina no Modelo de Diabetes Mellitus Induzido por Aloxano em Ratos. (Doctoral Dissertation). Universidade Federal do Ceará. Retrieved from http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=10526 ;

Chicago Manual of Style (16^th Edition):

Garcia, Francisca Adilfa de Oliveira. “Estudo dos PossÃveis Mecanismos da AÃÃo Hipoglicemiante da Pentoxifilina no Modelo de Diabetes Mellitus Induzido por Aloxano em Ratos.” 2012. Doctoral Dissertation, Universidade Federal do Ceará. Accessed January 15, 2019. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=10526 ;.

MLA Handbook (7^th Edition):

Garcia, Francisca Adilfa de Oliveira. “Estudo dos PossÃveis Mecanismos da AÃÃo Hipoglicemiante da Pentoxifilina no Modelo de Diabetes Mellitus Induzido por Aloxano em Ratos.” 2012. Web. 15 Jan 2019.

Vancouver:

Garcia FAdO. Estudo dos PossÃveis Mecanismos da AÃÃo Hipoglicemiante da Pentoxifilina no Modelo de Diabetes Mellitus Induzido por Aloxano em Ratos. [Internet] [Doctoral dissertation]. Universidade Federal do Ceará 2012. [cited 2019 Jan 15]. Available from: http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=10526 ;.

Council of Science Editors:

Garcia FAdO. Estudo dos PossÃveis Mecanismos da AÃÃo Hipoglicemiante da Pentoxifilina no Modelo de Diabetes Mellitus Induzido por Aloxano em Ratos. [Doctoral Dissertation]. Universidade Federal do Ceará 2012. Available from: http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=10526 ;

13. Katia Linhares Lima Costa. âAvaliaÃÃo das condiÃÃes periodontais de diabÃticos do tipo 2 com diferentes nÃveis glicÃmicosâ.

Degree: Master, 2009, Universidade Federal do Ceará

URL: http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=4598 ;

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A diabetes Ã considerada um fator de risco significativo para a ocorrÃncia de doenÃas periodontais. Entretanto, Ã necessÃrio que estudos a respeito deste assunto seja… (more)

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A diabetes Ã considerada um fator de risco significativo para a ocorrÃncia de doenÃas periodontais. Entretanto, Ã necessÃrio que estudos a respeito deste assunto seja realizado em diferentes populaÃÃes, com diferentes caracterÃsticas. O objetivo deste estudo transversal foi avaliar os parÃmetros clÃnicos periodontais de diabÃticos do tipo 2 com diferentes padrÃes de controle glicÃmico. Foram selecionados portadores desta doenÃa, de ambos os gÃneros, residentes na sede do municÃpio de Sobral - CearÃ. Estes deveriam ser nÃo-fumantes, com idade igual ou superior a 40 anos, possuir pelo menos 6 dentes na arcada dentÃria e fazer uso de medicaÃÃo hipoglicemiante. Os indivÃduos foram submetidos ao exame clÃnico periodontal: Ãndice de placa visÃvel (IP), sangramento gengival (IG), sangramento Ã sondagem (SS), profundidade de sondagem (PS) e recessÃo gengival (RG), realizado por um examinador previamente calibrado. Os indivÃduos foram divididos em trÃs grupos de acordo os nÃveis de hemoglobina glicada â Hb1Ac (Controlados - C: Hb1Ac ≤ 7%, n=103; Descontrolados - D: 7,1% ≤ Hb1Ac ≤ 9%, n= 60; Elevado Descontrole = E: Hb1Ac ≥ 9,1%, n=22). NÃo foram observadas diferenÃas significantes em relaÃÃo Ãs mÃdias de idade em anos, mÃdia de dentes presentes, IP, IG e SS. Verificou-se diferenÃa significante entre os grupos para as mÃdias de Hb1Ac e tempo de diagnÃstico da doenÃa. NÃo foi verificada associaÃÃo estatisticamente significante entre elevados nÃveis glicÃmicos e a maior presenÃa de dentes e de sÃtios periodontais com PS ≥ 6 mm. Entretanto quando foram analisados apenas os indivÃduos que apresentaram 20 ou mais dentes isso foi observado. Assim, pÃde-se concluir que o pobre controle glicÃmico dos diabÃticos do tipo 2, foi associado a maior presenÃa de periodontite apenas nos indivÃduos com elevado nÃmero de dentes.

Diabetes is a significant risk factor for the occurrence of periodontal diseases. Studying the relationship of both diseases in different populations with heterogeneous characteristics are still necessary to better understand them. The aim of this cross-sectional study was to evaluate the clinical periodontal parameters of type 2 diabetes patients with different levels of glycemic control. There were selected type 2 diabetics residing in the urban area of Sobral, Ceara. They must be non-smokers, aging 40 years or more and presenting at least and 6 teeth in their mouth. All had to be using any medication to control the glycemic level. Subjects were assigned to three groups based on their respective glycated hemoglobin levels - Hb1Ac (Control - C: Hb1Ac ≤ 7%, n=103; Moderate control - M: 7,1% ≤ Hb1Ac ≤ 9%, n= 60; Poor control = P: Hb1Ac ≥ 9,1%, n=22). The following clinical data were obtained from all patients: Plaque Index (PI), Gingival Index (GI), bleeding on probing (BOP), probing depth (PD) and gingival recession (GR). The mean age, number of teeth, PI, GI and BOP did not show any significance between groups. But this was observed for Hb1Ac mean levels and time…

Advisors/Committee Members: Rodrigo OtÃvio CitÃ CÃsar RÃgo.

Subjects/Keywords: CLINICA ODONTOLOGICA; Diabetes Mellitus tipo 2; DoenÃas Periodontais; Hemoglobina; diabetes mellitus type 2; periodontal diseases; glycated hemoglobin

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Costa, K. L. L. (2009). âAvaliaÃÃo das condiÃÃes periodontais de diabÃticos do tipo 2 com diferentes nÃveis glicÃmicosâ. (Masters Thesis). Universidade Federal do Ceará. Retrieved from http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=4598 ;

Chicago Manual of Style (16^th Edition):

Costa, Katia Linhares Lima. “âAvaliaÃÃo das condiÃÃes periodontais de diabÃticos do tipo 2 com diferentes nÃveis glicÃmicosâ.” 2009. Masters Thesis, Universidade Federal do Ceará. Accessed January 15, 2019. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=4598 ;.

MLA Handbook (7^th Edition):

Costa, Katia Linhares Lima. “âAvaliaÃÃo das condiÃÃes periodontais de diabÃticos do tipo 2 com diferentes nÃveis glicÃmicosâ.” 2009. Web. 15 Jan 2019.

Vancouver:

Costa KLL. âAvaliaÃÃo das condiÃÃes periodontais de diabÃticos do tipo 2 com diferentes nÃveis glicÃmicosâ. [Internet] [Masters thesis]. Universidade Federal do Ceará 2009. [cited 2019 Jan 15]. Available from: http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=4598 ;.

Council of Science Editors:

Costa KLL. âAvaliaÃÃo das condiÃÃes periodontais de diabÃticos do tipo 2 com diferentes nÃveis glicÃmicosâ. [Masters Thesis]. Universidade Federal do Ceará 2009. Available from: http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=4598 ;

14. 주, 미선. The relationship between Glycemic control and Periodontal disease in Korean adult.

Degree: 2017, Ajou University

URL: http://repository.ajou.ac.kr/handle/201003/16490 ; http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000024702

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Purpose : The present study investigated the effect of blood sugar (HbA1c) control level on periodontal disease among Korean adults. Participants & Methods: The present… (more)

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Purpose : The present study investigated the effect of blood sugar (HbA1c) control level on periodontal disease among Korean adults. Participants & Methods: The present study utilized data from Korea National Health & Nutrition Examination Survey (KNHANES) VI (2013-2014). Among the 15,568 adult subjects, 7,205 who responded to the key variable questions were selected as the final subjects for the study. Subjects’ data were again divided based on key variables such as demographics, living habits, oral health manners, diabetes management and were analyzed using chi-square tests, ANOVA, and logistical regression analysis. No necessity of specific preparation and convenience of analyzing the previous 2~3 months of blood sugar control level for diabetic patients makes diagnostic tests using glycated hemoglobin more popular over the previous standard diabetic diagnostic test. In this respect, the current study investigated the relationship between glycated hemoglobin and periodontal disease. Periodontal disease was measured using the Community Periodontal Index of Treatment Needs (CPITN) based on the periodontal tissue point-system created by the KNHNES. Data from the current study were analyzed using IBM SPSS Statistics 23 using analysis methods appropriate for a complex sampling design structure. Results: Within a confidence range of 95%, the odds ratio for a normal blood sugar control level (glycated hemoglobin less than or equal to 5.7%), to pre-diabetic blood sugar control level (5.8% - 6.4%) was 1.470 and that for a normal blood sugar control level (5.7%) to diabetic stage (greater than or equal to 6.5%) was 2.325. Conclusions: The results from the current study demonstrate that the less well-controlled blood sugar level is (i.e. when glycated hemoglobin rate was higher), the more subjects were likely to be infected by periodontal diseases. On the basis of our study, it is highly recommended that dentists and dental hygienists must emphasize the importance of blood sugar control upon dental appointment of patients with periodontal diseases.

목적 : 한국 성인에서 치주질환 여부에 대하여 혈당 조절정도(당화혈색소)가 어느 정도의 크기로 영향을 미치는지 알아보고자 하였다. 대상 및 방법 : 국민건강영양조사 제 6기 1, 2차 년도(2013~2014년) 자료를 가중치 비율 1:1로 통합하여 사용하였다. 성인에 해당되는 최초 대상자 15,568명 중 주요 변수 응답자인 7,205명을 최종 대상자로 선정하였다. 이를 대상으로 인구사회학적 특성, 생활습관, 구강보건행태, 당뇨병 관리 정도를 각 변수로 구분하여 카이제곱 검정(chi-square test)과 분산분석(ANOVA), 로지스틱 회귀분석을 실시하였다. 진단검사 전 특별한 준비가 필요하지 않으며, 당뇨병 환자에서 최근 2~3개월간의 혈당 조절정도를 분석하기에 용이하다는 등의 이유를 들어 기존의 당뇨병 진단 방법보다는 당화혈색소를 통한 진단 방법이 주목받고 있다. 이에 따라 본 연구에서도 당화혈색소와 치주질환과의 관계를 보고자 하였다. 치주질환 여부의 경우, 국민건강영양조사에서 치주조직 점수부여 원칙으로 사용한 지역사회치주요양필요지수(Community Periodontal Index of Treatment Needs, CPITN)를 활용하였다. 본 연구의 모든 자료 분석은 IBM SPSS Statistics 23 프로그램을 사용하였고, 복합표본설계에 맞는 방법으로 분석을 실시하였다. 연구결과 : 95% 신뢰구간에서 혈당 조절정도(당화혈색소)가 정상(5.7%이하)일 때에 비해 당뇨병 전 단계(5.8%~6.4%)일 때 승산비는 1.470으로 분석되었으며, 정상일 때에 비해 당뇨(6.5%이상)일 때 승산비는 2.325로 분석되었다. 결론 : 본 연구에서는 혈당 조절이 잘 되지 않을수록 즉, 당화혈색소 수치가 높아질수록 치주질환에 이환될 확률이 높아짐을 알 수 있었다. 이에 향후 치주질환 및 당뇨병에 이환된 자가 치과에 내원하였을 때, 본 연구의 결과를 기초자료로 활용하여 혈당 조절의 중요성을 강조는 것이 필요할 것이라고 사료된다.

Ⅰ. 서…

Advisors/Committee Members: 보건대학원, 201530025, 주, 미선.

Subjects/Keywords: Diabetes; Glycated Hemoglobin; Periodontal Disease; Blood Sugar; Blood Sugar Control; HbA1c; A1C; 당뇨병; 당화혈색소; 치주질환; 혈당; 혈당조절

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

주, �. (2017). The relationship between Glycemic control and Periodontal disease in Korean adult. (Thesis). Ajou University. Retrieved from http://repository.ajou.ac.kr/handle/201003/16490 ; http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000024702

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

주, 미선. “The relationship between Glycemic control and Periodontal disease in Korean adult.” 2017. Thesis, Ajou University. Accessed January 15, 2019. http://repository.ajou.ac.kr/handle/201003/16490 ; http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000024702.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

주, 미선. “The relationship between Glycemic control and Periodontal disease in Korean adult.” 2017. Web. 15 Jan 2019.

Vancouver:

주 �. The relationship between Glycemic control and Periodontal disease in Korean adult. [Internet] [Thesis]. Ajou University; 2017. [cited 2019 Jan 15]. Available from: http://repository.ajou.ac.kr/handle/201003/16490 ; http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000024702.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

주 �. The relationship between Glycemic control and Periodontal disease in Korean adult. [Thesis]. Ajou University; 2017. Available from: http://repository.ajou.ac.kr/handle/201003/16490 ; http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000024702

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

George Mason University

15. Harpole, Michael George. Exploration of the Diabetic Urinary Proteome via Hydrogel Nanotechnology and Proof of Principle of a Non-Invasive A1c Assay .

Degree: George Mason University

URL: http://hdl.handle.net/1920/10991

► An urgent need exists to develop non invasive diagnostic tests to monitor chronic health conditions such as diabetes. Urine is an attractive biofluid that holds… (more)

Subjects/Keywords: nanotechnology; urinary proteome; diabetes; glycated hemoglobin; A1c; hydrogel nanoparticles

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Harpole, M. G. (n.d.). Exploration of the Diabetic Urinary Proteome via Hydrogel Nanotechnology and Proof of Principle of a Non-Invasive A1c Assay . (Thesis). George Mason University. Retrieved from http://hdl.handle.net/1920/10991

Note: this citation may be lacking information needed for this citation format:
No year of publication.
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Harpole, Michael George. “Exploration of the Diabetic Urinary Proteome via Hydrogel Nanotechnology and Proof of Principle of a Non-Invasive A1c Assay .” Thesis, George Mason University. Accessed January 15, 2019. http://hdl.handle.net/1920/10991.

Note: this citation may be lacking information needed for this citation format:
No year of publication.
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Harpole, Michael George. “Exploration of the Diabetic Urinary Proteome via Hydrogel Nanotechnology and Proof of Principle of a Non-Invasive A1c Assay .” Web. 15 Jan 2019.

Note: this citation may be lacking information needed for this citation format:
No year of publication.

Vancouver:

Harpole MG. Exploration of the Diabetic Urinary Proteome via Hydrogel Nanotechnology and Proof of Principle of a Non-Invasive A1c Assay . [Internet] [Thesis]. George Mason University; [cited 2019 Jan 15]. Available from: http://hdl.handle.net/1920/10991.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
No year of publication.

Council of Science Editors:

Harpole MG. Exploration of the Diabetic Urinary Proteome via Hydrogel Nanotechnology and Proof of Principle of a Non-Invasive A1c Assay . [Thesis]. George Mason University; Available from: http://hdl.handle.net/1920/10991

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
No year of publication.

University of Arkansas

16. Mandal, Sanghamitra. Glucose Level Estimation Based on Invasive Electrochemical, and Non-Invasive Optical Sensing Methods.

Degree: PhD, 2018, University of Arkansas

URL: http://scholarworks.uark.edu/etd/2731

► The purpose of this research is to design and fabricate sensors for glucose detection using inexpensive approaches. My first research approach is the fabrication… (more)

▼ The purpose of this research is to design and fabricate sensors for glucose detection using inexpensive approaches. My first research approach is the fabrication of an amperometric electrochemical glucose sensor, by exploiting the optical properties of semiconductors and structural properties of nanostructures, to enhance the sensor sensitivity and response time. Enzymatic electrochemical sensors are fabricated using two different mechanisms: (1) the low-temperature hydrothermal synthesis of zinc oxide nanorods, and (2) the rapid metal-assisted chemical etching of silicon (Si) to synthesize Si nanowires. The concept of gold nano-electrode ensembles is then employed to the sensors in order to boost the current sensitivities by enhancing the rate of electron transfer during the electrochemical reaction. High crystallinity and good alignment of the nanostructures lead to increase in the electrode surface area, thereby leading to higher current sensitivities compared to other published works. My second research approach is to design an optical sensor for evaluating long-term glycemic state in diabetic patients. Glycated hemoglobin (HbA1c) is a minor component of blood hemoglobin to which glucose is bound. The HbA1c test is a common medical test used to indicate the average blood glucose level over the past 12-16 weeks. The National Institute of Diabetes and Digestive and Kidney Diseases has established a direct relationship between the percentage of HbA1c and the blood sugar level. Our sensor instrumentation design is based on the Beer’s law of optical absorption. Major device components include two commercial light emitting diodes, a cuvette holder, a Si photodiode, and an ATmega328P microcontroller. It is observed that the absorbance of diluted HbA1c samples and the corresponding photodiode output voltage are inversely related. The photodiode voltages as a function of HbA1c percentage concentrations show an exponentially decaying curve. An algorithm for multiple variable regression analysis is then used for sensor calibration. The percentage of HbA1c is then anticipated based on the obtained output voltage using the calibrated curve results. The proposed portable optical sensor proves to be a promising step towards the prediction of the long-term glycemic levels in diabetic and pre-diabetic patients non-invasively. Advisors/Committee Members: Omar Manasreh, Timothy Muldoon, Simon Ang.

Subjects/Keywords: Electrochemical Sensor; Glucose Sensor; Glycated Hemoglobin; Nanostructures; Optical Sensor; ZnO Nanorods; Electronic Devices and Semiconductor Manufacturing; Nanoscience and Nanotechnology; Nanotechnology Fabrication; Semiconductor and Optical Materials

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Mandal, S. (2018). Glucose Level Estimation Based on Invasive Electrochemical, and Non-Invasive Optical Sensing Methods. (Doctoral Dissertation). University of Arkansas. Retrieved from http://scholarworks.uark.edu/etd/2731

Chicago Manual of Style (16^th Edition):

Mandal, Sanghamitra. “Glucose Level Estimation Based on Invasive Electrochemical, and Non-Invasive Optical Sensing Methods.” 2018. Doctoral Dissertation, University of Arkansas. Accessed January 15, 2019. http://scholarworks.uark.edu/etd/2731.

MLA Handbook (7^th Edition):

Mandal, Sanghamitra. “Glucose Level Estimation Based on Invasive Electrochemical, and Non-Invasive Optical Sensing Methods.” 2018. Web. 15 Jan 2019.

Vancouver:

Mandal S. Glucose Level Estimation Based on Invasive Electrochemical, and Non-Invasive Optical Sensing Methods. [Internet] [Doctoral dissertation]. University of Arkansas; 2018. [cited 2019 Jan 15]. Available from: http://scholarworks.uark.edu/etd/2731.

Council of Science Editors:

Mandal S. Glucose Level Estimation Based on Invasive Electrochemical, and Non-Invasive Optical Sensing Methods. [Doctoral Dissertation]. University of Arkansas; 2018. Available from: http://scholarworks.uark.edu/etd/2731

Indian Institute of Science

17. Kumar, Vinay. Electrochemical Biosensors based on Novel Receptors for Diabetes Management.

Degree: 2016, Indian Institute of Science

URL: http://hdl.handle.net/2005/3016

► To address the challenge of accurate, low cost and robust biosensors for diabetes management and early detection of diabetes complications, we have developed novel, robust… (more)

▼ To address the challenge of accurate, low cost and robust biosensors for diabetes management and early detection of diabetes complications, we have developed novel, robust sensing chemistry (or receptors) for electrochemical POC biosensors. The biosensors have been developed for the bio-markers associated with diabetes management such as glycated haemoglobin (HbA1c), glycated albumin, glucose, biomarkers associated with diabetes complications such as microalbuminuria, urine creatinine and albumin-to-creatinine ratio (ACR) and biomarkers associated with anaemia and malnutrition conditions such as haemoglobin and serum albumin. For haemoglobin detection, a new POC bio sensing technique has been developed based on Aza-heterocyclic chemicals. The repeatability and accuracy of the biosensor have been tested on real pathology samples. The glycated form of haemoglobin, called glycated haemoglobin or HbA1c, is the gold standard test in diabetes management as it gives the 90-days average blood glucose value. We demonstrate a simple method for electrochemical detection of HbA1c by combining bosonic affinity principle along with aza-heterocyclic receptors. The technique has been verified on the real clinical patient samples. Albumin is the most abundant protein in the human blood. Human serum albumin (HSA) is either alone or an associative biomarker in several chronic diseases like necrosis, nephrosis, hepatitis, malnutrition, arthritis, immune disorders, cancer, diabetes and in some severe infections. In pathology laboratories, the serum albumin is usually tested on serum samples and not in whole blood samples. Since albumin is not a metalloproteinase, it is very difficult to develop electrochemical POC biosensor. We have developed a novel technique for the electrochemical detection of serum albumin in whole blood samples, by exploiting its binding property with redox active copper salts. The accuracy of technique has been verified on both real human blood plasma as well as whole blood samples. Glycated albumin, which is the glycated form of serum albumin, is emerging as a novel biomarker for diabetes management, as it gives the average blood glucose value of 15-20 days. It is also extremely useful in chronic kidney disease patients and patients with hemoglobinopathies where HbA1c can give the erroneous results. By combining the copper chemistry along with bosonic affinity principle, we present the first ever demonstration of glycated albumin sensing. Instant blood glucose monitoring is an integral part of diabetes management. Most of the glucometers available in the market are based on glucose oxidase enzyme. We have demonstrated a low cost non-enzymatic electrochemical technique for blood glucose detection using alkaline methylene blue chemistry. The accuracy of the technique has been verified on real human blood plasma samples. Glucometer is one of the most easily available POC biosensor and a useful tool for diabetes population. India has second largest diabetes population in the world. To analyse the accuracy of the… Advisors/Committee Members: Bhat, Navakanta.

Subjects/Keywords: Electrochemical Biosensors; Targeted Biomarkers; Hemoglogin Electrochemical Detection; Glycated Hemoglobin Electrochemical Detection; Human Serum Albumin Electrochemical Detection; Glycated Albumin Electrochemical Detection; Blood Glucose Electrochemical Detection; Microalubuminuria Electrochemical Detection; Urine Creatinine Electrochemical Detection; Electrochemical Point of Care Biosensors; Diabetes Management-Electrochemical Biosensors; Electrochemical Glucose Biosensors; Blood Glucose; Nano Science and Engineering

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Kumar, V. (2016). Electrochemical Biosensors based on Novel Receptors for Diabetes Management. (Thesis). Indian Institute of Science. Retrieved from http://hdl.handle.net/2005/3016

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Kumar, Vinay. “Electrochemical Biosensors based on Novel Receptors for Diabetes Management.” 2016. Thesis, Indian Institute of Science. Accessed January 15, 2019. http://hdl.handle.net/2005/3016.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Kumar, Vinay. “Electrochemical Biosensors based on Novel Receptors for Diabetes Management.” 2016. Web. 15 Jan 2019.

Vancouver:

Kumar V. Electrochemical Biosensors based on Novel Receptors for Diabetes Management. [Internet] [Thesis]. Indian Institute of Science; 2016. [cited 2019 Jan 15]. Available from: http://hdl.handle.net/2005/3016.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Kumar V. Electrochemical Biosensors based on Novel Receptors for Diabetes Management. [Thesis]. Indian Institute of Science; 2016. Available from: http://hdl.handle.net/2005/3016

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universidad de Extremadura

18. Murillo García, Diego. Evolución del fondo de ojo con respecto a las cifras de hemoglobina glucada.

Degree: 2018, Universidad de Extremadura

URL: http://hdl.handle.net/10662/6530

Subjects/Keywords: Diabetes; Retinopatía; Hemoglobina glucada HbA1c; Retinopathy; HbA1c glycated hemoglobin; 3206.02 Metabolismo Energético; 3201.09 Oftalmología; 3212 Salud Publica; 3206.99 Otras

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Murillo García, D. (2018). Evolución del fondo de ojo con respecto a las cifras de hemoglobina glucada. (Thesis). Universidad de Extremadura. Retrieved from http://hdl.handle.net/10662/6530

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Murillo García, Diego. “Evolución del fondo de ojo con respecto a las cifras de hemoglobina glucada.” 2018. Thesis, Universidad de Extremadura. Accessed January 15, 2019. http://hdl.handle.net/10662/6530.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Murillo García, Diego. “Evolución del fondo de ojo con respecto a las cifras de hemoglobina glucada.” 2018. Web. 15 Jan 2019.

Vancouver:

Murillo García D. Evolución del fondo de ojo con respecto a las cifras de hemoglobina glucada. [Internet] [Thesis]. Universidad de Extremadura; 2018. [cited 2019 Jan 15]. Available from: http://hdl.handle.net/10662/6530.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Murillo García D. Evolución del fondo de ojo con respecto a las cifras de hemoglobina glucada. [Thesis]. Universidad de Extremadura; 2018. Available from: http://hdl.handle.net/10662/6530

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

19. Reaver, Nathan George Frederick. Development and Characterization of Aptamers for the use in Surface Plasmon Resonance Sensors for the Detection of Glycated Blood Proteins.

Degree: MSin Bioengineering, Bioengineering, 2013, University of Toledo

URL: http://rave.ohiolink.edu/etdc/view?acc_num=toledo1373319138

► The concentration ratio of glycated to non-glycated forms of various blood proteins can be used as a diagnostic measure in diabetes to determine a history… (more)

Subjects/Keywords: Biomedical Research; Biochemistry; Chemistry; Engineering; Health Care; Health Sciences; Medicine; Molecular Chemistry; Optics; Organic Chemistry; Technology; Biomedical Engineering; aptamer; aptamers; surface plasmon resonance; SPR; diabetes mellitus; glycated protein; biosensor; hemoglobin; glycated hemoglobin; SELEX; Systematic Evolution of Ligands by Exponential Enrichment; fibrinogen; non-enzymatic glycosylation; plasmonics

…158 C Identified Aptamer Sequences C.1 Potential Glycated Hemoglobin Aptamers… …164 D.2 Potential Aptamer Binding Sites – Glycated Hemoglobin ..........................167… …172 D.5 Aptamer Structures – Glycated Hemoglobin… …glycated hemoglobin aptamers… …glycated hemoglobin aptamers…

10 more images…

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Reaver, N. G. F. (2013). Development and Characterization of Aptamers for the use in Surface Plasmon Resonance Sensors for the Detection of Glycated Blood Proteins. (Masters Thesis). University of Toledo. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=toledo1373319138

Chicago Manual of Style (16^th Edition):

Reaver, Nathan George Frederick. “Development and Characterization of Aptamers for the use in Surface Plasmon Resonance Sensors for the Detection of Glycated Blood Proteins.” 2013. Masters Thesis, University of Toledo. Accessed January 15, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1373319138.

MLA Handbook (7^th Edition):

Reaver, Nathan George Frederick. “Development and Characterization of Aptamers for the use in Surface Plasmon Resonance Sensors for the Detection of Glycated Blood Proteins.” 2013. Web. 15 Jan 2019.

Vancouver:

Reaver NGF. Development and Characterization of Aptamers for the use in Surface Plasmon Resonance Sensors for the Detection of Glycated Blood Proteins. [Internet] [Masters thesis]. University of Toledo; 2013. [cited 2019 Jan 15]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=toledo1373319138.

Council of Science Editors:

Reaver NGF. Development and Characterization of Aptamers for the use in Surface Plasmon Resonance Sensors for the Detection of Glycated Blood Proteins. [Masters Thesis]. University of Toledo; 2013. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=toledo1373319138

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