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You searched for subject:(Glaucoma Treatment Research). Showing records 1 – 3 of 3 total matches.

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Macquarie University

1. Chu, Edward Rickie Lim. Artificial simulation of th aqueous humor dynamics of the conventional outflow pathway under physiological and pathological conditions.

Degree: 2016, Macquarie University

Empirical thesis.

Bibliography: pages 66-80.

Chapter 1. Introduction  – Chapter 2. Materials and methods  – Chapter 3. Empirical insights into conventional outflow dynamics from an artificial hydraulic model  – Chapter 4. Understanding abnormal outflow resistance and episcleral venous pressure in an artificial hydraulic model of the conventional aqueous drainage  – Chapter 5. Limitations, conclusion and future directions.

Glaucoma is the leading cause of irreversible blindness in the world and remains a devastating ophthalmic condition. Current management seems limited and focuses mainly on reducing intraocular pressure. Glaucoma research models such as cell and organ based culture, computer simulation and animal models have played major roles in advancing the field, however, disease progression still occurs indicative that the pathophysiology of glaucoma has not been fully elucidated. In an attempt to shed some light into this issue, a novel artificial hydraulic model has been developed to empirically simulate fluid dynamics of the human conventional outflow pathway. Using non-biological materials, this model comprised of critical elements of the human aqueous outflow tract that include a microsyringe pump (simulating aqueous inflow/outflow), 35-gauge needle (stimulating trabecular meshwork), one way valve (simulating Schlemm’s canal inner wall endothelia) and a distal fluid column (simulating episcleral venous pressure) interconnected in between by pressure transducers and rigid tubings. The model was able to replicate various components of the conventional outflow pathway under physiological and pathological conditions. This system can potentially provide options to incorporate biological materials (i.e. cell cultures), include a parallel uveoscleral outflow system and/or simulate collector channel resistance to create a more comprehensive model to further our understanding in aqueous outflow dynamics.

1 online resource (80 pages) diagrams, graphs

Advisors/Committee Members: Macquarie University. Australian School of Advanced Medicine.

Subjects/Keywords: Glaucoma  – Treatment  – Research; Glaucoma  – Pathophysiology; artificiai simulation; model; aqueous humor dynamics; conventional outflow pathway; trabecular meshwork resistance; episcleral venous pressure; aqueous outflow pathology; glaucoma

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Chu, E. R. L. (2016). Artificial simulation of th aqueous humor dynamics of the conventional outflow pathway under physiological and pathological conditions. (Masters Thesis). Macquarie University. Retrieved from http://hdl.handle.net/1959.14/1099821

Chicago Manual of Style (16th Edition):

Chu, Edward Rickie Lim. “Artificial simulation of th aqueous humor dynamics of the conventional outflow pathway under physiological and pathological conditions.” 2016. Masters Thesis, Macquarie University. Accessed November 11, 2019. http://hdl.handle.net/1959.14/1099821.

MLA Handbook (7th Edition):

Chu, Edward Rickie Lim. “Artificial simulation of th aqueous humor dynamics of the conventional outflow pathway under physiological and pathological conditions.” 2016. Web. 11 Nov 2019.

Vancouver:

Chu ERL. Artificial simulation of th aqueous humor dynamics of the conventional outflow pathway under physiological and pathological conditions. [Internet] [Masters thesis]. Macquarie University; 2016. [cited 2019 Nov 11]. Available from: http://hdl.handle.net/1959.14/1099821.

Council of Science Editors:

Chu ERL. Artificial simulation of th aqueous humor dynamics of the conventional outflow pathway under physiological and pathological conditions. [Masters Thesis]. Macquarie University; 2016. Available from: http://hdl.handle.net/1959.14/1099821


Macquarie University

2. Sriram, Prema. Identification and characterisation of ganglion cell loss in optic neuropathies.

Degree: 2014, Macquarie University

"A thesis submitted to Macquarie University in fulfillment of the requirements for the degree of Doctor of Philosophy"

"May 2014"

Bibliography:pages 166-224.

Chapter 1. Introduction to ganglion cells  – Chapter 2. Structural and functional identification of early glaucoma  – Chapter 3. Reproducibility of multifocal VEP latency using different stimulus presentations  – Chapter 4. Optic neuropathy in multiple sclerosis  – Chapter 5. Transsynaptic retinal degeneration in optic neuropathies : optical coherence tomography study  – Chapter 6. Conclusion.

This thesis explores the identification of ganglion cell loss in optic neuropathies, and utilizes new technologies. Two commonly prevalent optic neuropathies have been studied – Glaucoma, which is common among the older population and Mutiple Sclerosis (MS) associated optic neuropathy, which is more prevalent in the younger population.

The aim of the glaucoma study was to identify the combination of the tests that would identify very early loss of ganglion cells. Knowledge of this impact will then allow clinicians to identify patients with early glaucomatous damage and start treatment before evident visual field loss. The study revealed that Heidelberg retina tomograph (HRT) and Low contrast multifocal visual evoked potential (LLA mfVEP) were two sensitive tests in detecting patients with preperimetric and early glaucomatous defects. The aim of the MS study was to identify ganglion cell loss in patients with MS with or without previous history of Optic Neuritis (ON). The study also aimed to prove if the eye is a primary site of neurodegeneration in patients with multiple sclerosis. This could possibly shed some light in the pathological changes in the eye that occurs with MS related neurodegeneration. The results of the study indicated the presence of a trans neuronal degeneration, which could be retrograde (from optic radiation to retina) or anterograde (from retina to visual cortex). We also proved the absence of retrograde degeneration since the ERG changes were of similar magnitude in both ON and NON eyes of MS patients.

1 online resource (224 pages) illustrations (some colour), graphs, charts

Advisors/Committee Members: Macquarie University. Australian School of Advanced Medicine.

Subjects/Keywords: Glaucoma; Glaucoma  – Diagnosis; Glaucoma  – Treatment; Glaucoma  – Research; ganglion cell loss; glaucoma; optic neuropathies; Multiple Sclerosis; Heidelberg retina tomograph; HRT; low contrast multifocal visual; optic neuritis; eye; trans neuronal degeneration; retrograde; anterogade; retina; visual pathway

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APA (6th Edition):

Sriram, P. (2014). Identification and characterisation of ganglion cell loss in optic neuropathies. (Doctoral Dissertation). Macquarie University. Retrieved from http://hdl.handle.net/1959.14/1142345

Chicago Manual of Style (16th Edition):

Sriram, Prema. “Identification and characterisation of ganglion cell loss in optic neuropathies.” 2014. Doctoral Dissertation, Macquarie University. Accessed November 11, 2019. http://hdl.handle.net/1959.14/1142345.

MLA Handbook (7th Edition):

Sriram, Prema. “Identification and characterisation of ganglion cell loss in optic neuropathies.” 2014. Web. 11 Nov 2019.

Vancouver:

Sriram P. Identification and characterisation of ganglion cell loss in optic neuropathies. [Internet] [Doctoral dissertation]. Macquarie University; 2014. [cited 2019 Nov 11]. Available from: http://hdl.handle.net/1959.14/1142345.

Council of Science Editors:

Sriram P. Identification and characterisation of ganglion cell loss in optic neuropathies. [Doctoral Dissertation]. Macquarie University; 2014. Available from: http://hdl.handle.net/1959.14/1142345

3. Gupta, Manav. Differentiation and characterization of cell types associated with retinal degenerative diseases using human induced pluripotent stem cells.

Degree: 2014, IUPUI

Indiana University-Purdue University Indianapolis (IUPUI)

Human induced pluripotent stem (iPS) cells have the unique ability to differentiate into 200 or so somatic cell types that make up the adult human being. The use of human iPS cells to study development and disease is a highly exciting and interdependent field that holds great promise in understanding and elucidating mechanisms behind cellular differentiation with future applications in drug screening and cell replacement studies for complex and currently incurable cellular degenerative disorders. The recent advent of iPS cell technology allows for the generation of patient-specific cell lines that enable us to model the progression of a disease phenotype in a human in vitro model. Differentiation of iPS cells toward the affected cell type provides an unlimited source of diseased cells for examination, and to further study the developmental progression of the disease in vitro, also called the “disease-in-a-dish” model. In this study, efforts were undertaken to recapitulate the differentiation of distinct retinal cell affected in two highly prevalent retinal diseases, Usher syndrome and glaucoma. Using a line of Type III Usher Syndrome patient derived iPS cells efforts were undertaken to develop such an approach as an effective in vitro model for studies of Usher Syndrome, the most commonly inherited disorder affecting both vision and hearing. Using existing lines of iPS cells, studies were also aimed at differentiation and characterization of the more complex retinal cell types, retinal ganglion cells (RGCs) and astrocytes, the cell types affected in glaucoma, a severe neurodegenerative disease of the retina leading to eventual irreversible blindness. Using a previously described protocol, the iPS cells were directed to differentiate toward a retinal fate through a step-wise process that proceeds through all of the major stages of neuroretinal development. The differentiation process was monitored for a period of 70 days for the differentiation of retinal cell types and 150 days for astrocyte development. The different stages of differentiation and the individually derived somatic cell types were characterized by the expression of developmentally associated transcription factors specific to each cell type. Further approaches were undertaken to characterize the morphological differences between RGCs and other neuroretinal cell types derived in the process. The results of this study successfully demonstrated that Usher syndrome patient derived iPS cells differentiated to the affected photoreceptors of Usher syndrome along with other mature retinal cell types, chronologically analogous to the development of the cell types in a mature human retina. This study also established a robust method for the in vitro derivation of RGCs and astrocytes from human iPS cells and provided novel methodologies and evidence to characterize these individual somatic cell types. Overall, this study provides a unique insight into the application of human…

Advisors/Committee Members: Meyer, Jason S., Belecky-Adams, Teri, Randall, Stephen Karl, 1953-.

Subjects/Keywords: Degeneration; Differentiation; Disease Modeling; Glaucoma; Induced Pluripotent Stem Cell; Retina; Stem cells  – Therapeutic use  – Research; Usher's syndrome  – Pathophysiology; Usher's syndrome  – Alternative treatment; Glaucoma  – Alternative treatment; Retinitis pigmentosa  – Pathophysiology; Genetic disorders  – Diagnosis; Multipotent stem cells  – Research  – Analysis; Embryonic stem cells  – Research; Human cell culture  – Research; Cell differentiation  – Analysis; Stem cells  – Transplantation  – Methods; Cellular therapy; Retinal ganglion cells  – Research; Retinal degeneration; Cells  – Morphology; Regenerative medicine  – Research; Transcription factors; Astrocytes  – Morphology; Genetic engineering; Drug testing

…affected in two highly prevalent retinal diseases, Usher syndrome and glaucoma. Using a line of… …glaucoma, a severe neurodegenerative disease of the retina leading to eventual irreversible… …disease modeling of the retinal degenerative diseases: Usher syndrome and glaucoma. In… …reason for the loss of other cell 7 types [37]. Glaucoma, age-related macular… …most primary approach for the prospective treatment of these diseases. 1.4.2 Retinal… 

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Gupta, M. (2014). Differentiation and characterization of cell types associated with retinal degenerative diseases using human induced pluripotent stem cells. (Thesis). IUPUI. Retrieved from http://hdl.handle.net/1805/4839

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Gupta, Manav. “Differentiation and characterization of cell types associated with retinal degenerative diseases using human induced pluripotent stem cells.” 2014. Thesis, IUPUI. Accessed November 11, 2019. http://hdl.handle.net/1805/4839.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Gupta, Manav. “Differentiation and characterization of cell types associated with retinal degenerative diseases using human induced pluripotent stem cells.” 2014. Web. 11 Nov 2019.

Vancouver:

Gupta M. Differentiation and characterization of cell types associated with retinal degenerative diseases using human induced pluripotent stem cells. [Internet] [Thesis]. IUPUI; 2014. [cited 2019 Nov 11]. Available from: http://hdl.handle.net/1805/4839.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Gupta M. Differentiation and characterization of cell types associated with retinal degenerative diseases using human induced pluripotent stem cells. [Thesis]. IUPUI; 2014. Available from: http://hdl.handle.net/1805/4839

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

.