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You searched for subject:(Ginkgo biloba extract). Showing records 1 – 2 of 2 total matches.

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Brno University of Technology

1. Fojtíková, Veronika. Přehled současných preparátů - doplňků stravy uplatňující se při výživě mozkové tkáně: View of existing supplements for tissue of brain nutrition.

Degree: 2019, Brno University of Technology

This diploma thesis is related to usage of food supplements in general. It observes which food supplements are mostly used, how often and in which period they are used and also which supplements forms population prefer. Next is this diploma paper focused on supplements for the support of cerebration, concretely up to supplements containing Ginkgo biloba. It studies their vascular activity, effect on memory and concentricity in various age groups. Also HPLC method for quick analysis of selected food supplements containing Ginkgo biloba was tested. Advisors/Committee Members: Vránová, Dana (advisor), Zemanová, Jana (referee).

Subjects/Keywords: Ginkgo biloba; HPLC; kvercetin; Ginkgo biloba extract; HPLC; quercetin

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Fojtíková, V. (2019). Přehled současných preparátů - doplňků stravy uplatňující se při výživě mozkové tkáně: View of existing supplements for tissue of brain nutrition. (Thesis). Brno University of Technology. Retrieved from http://hdl.handle.net/11012/12953

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Fojtíková, Veronika. “Přehled současných preparátů - doplňků stravy uplatňující se při výživě mozkové tkáně: View of existing supplements for tissue of brain nutrition.” 2019. Thesis, Brno University of Technology. Accessed January 23, 2021. http://hdl.handle.net/11012/12953.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Fojtíková, Veronika. “Přehled současných preparátů - doplňků stravy uplatňující se při výživě mozkové tkáně: View of existing supplements for tissue of brain nutrition.” 2019. Web. 23 Jan 2021.

Vancouver:

Fojtíková V. Přehled současných preparátů - doplňků stravy uplatňující se při výživě mozkové tkáně: View of existing supplements for tissue of brain nutrition. [Internet] [Thesis]. Brno University of Technology; 2019. [cited 2021 Jan 23]. Available from: http://hdl.handle.net/11012/12953.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Fojtíková V. Přehled současných preparátů - doplňků stravy uplatňující se při výživě mozkové tkáně: View of existing supplements for tissue of brain nutrition. [Thesis]. Brno University of Technology; 2019. Available from: http://hdl.handle.net/11012/12953

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation


University of British Columbia

2. Yeung, Eugene Y. H. Activation of pregnane X receptor by Ginkgo biloba extract.

Degree: MS- MSc, Pharmaceutical Sciences, 2008, University of British Columbia

Pregnane X receptor (PXR) is a ligand-activated transcription factor that plays a role in a broad array of biological processes, including drug metabolism and transport. Ginkgo biloba is an herb commonly used to improve cognitive function. In primary cultures of rat hepatocytes, Ginkgo biloba induces the mRNA expression of CYP3A23, a target gene for rat PXR. The present study tested the hypothesis that Ginkgo biloba activates PXR. Cultured HepG2 human hepatoma cells were transfected with the full-length human PXR (pCR3-hPXR), the full-length mouse PXR (pCR3-mPXR), or an empty vector (pCR3) in addition to a reporter plasmid (XREM-CYP3A4-LUC; firefly luciferase) and an internal control plasmid (phRL-TK; Renilla luciferase). At 24 h after transfection, cells were treated for 24 h with Ginkgo biloba extract and luciferase activity was measured. The extract at 200 µg/ml increased mouse and human PXR activity by 3.0-fold and 9.5-fold, respectively, indicating that Ginkgo biloba more effectively activates human PXR. Dose-response experiments showed that the extract produced a log-linear increase over the range of 200–800 µg/ml. To determine whether Ginkgo biloba extract induces human PXR target gene expression, cultured LS180 human colon adenocarcinoma cells were treated for 72 h with the extract. Total cellular RNA was isolated and reverse transcribed. CYP3A4, CYP3A5, and ABCB1 cDNAs were amplified by real-time PCR. Ginkgo biloba extract at 200, 400, and 800 µg/ml increased CYP3A4 mRNA expression by 1.7-, 2.4-, and 2.5-fold, respectively. The extract at the same concentrations increased the mRNA expression of CYP3A5 (1.3 to 3.6-fold) and ABCB1 (2.7 to 6.4-fold). To determine whether the increased expression involved PXR activation, cells were treated with a PXR antagonist, L-sulforaphane, and Ginkgo biloba extract. L-sulforaphane at 5, 10, and 20 µM decreased CYP3A4 mRNA expression by 54%, 78%, and 93%, respectively, in cells co-treated with the extract. A similar pattern of response was obtained with CYP3A5 and ABCB1. In cells co-treated with the extract, L-sulforaphane (5 and 10 µM) was not cytotoxic and did not decrease PXR mRNA expression. Our data from cell culture experiments indicate that Ginkgo biloba activates PXR and increases CYP3A4, CYP3A5, and ABCB1 mRNA expression.

Subjects/Keywords: Pregnane X receptor; Ginkgo biloba extract

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Yeung, E. Y. H. (2008). Activation of pregnane X receptor by Ginkgo biloba extract. (Masters Thesis). University of British Columbia. Retrieved from http://hdl.handle.net/2429/2688

Chicago Manual of Style (16th Edition):

Yeung, Eugene Y H. “Activation of pregnane X receptor by Ginkgo biloba extract.” 2008. Masters Thesis, University of British Columbia. Accessed January 23, 2021. http://hdl.handle.net/2429/2688.

MLA Handbook (7th Edition):

Yeung, Eugene Y H. “Activation of pregnane X receptor by Ginkgo biloba extract.” 2008. Web. 23 Jan 2021.

Vancouver:

Yeung EYH. Activation of pregnane X receptor by Ginkgo biloba extract. [Internet] [Masters thesis]. University of British Columbia; 2008. [cited 2021 Jan 23]. Available from: http://hdl.handle.net/2429/2688.

Council of Science Editors:

Yeung EYH. Activation of pregnane X receptor by Ginkgo biloba extract. [Masters Thesis]. University of British Columbia; 2008. Available from: http://hdl.handle.net/2429/2688

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