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University of Illinois – Chicago
1.
Lazari, Paul.
Secretory Micro-RNA 29 in Gingival Crevicular Fluid During Canine Retraction.
Degree: 2016, University of Illinois – Chicago
URL: http://hdl.handle.net/10027/20907 
► Introduction: Gingival crevicular fluid (GCF) has been widely investigated as a potential source of biomarkers for an individual’s oral and general health information. MicroRNAs (miRNAs)…
(more)
▼ Introduction:
Gingival crevicular fluid (
GCF) has been widely investigated as a potential source of biomarkers for an individual’s oral and general health information. MicroRNAs (miRNAs) are non-coding RNAs that are involved in post-transcriptional gene regulation. In this study, we investigated potentials of certain miRNAs in
GCF as biomarkers for detection of periodontal remodeling during OTM. The aim of the study was to confirm the presence of secretory miRNAs in
GCF and investigate temporal expression profiles of specific secretory miRNAs during the course of orthodontic tooth movement.
Methods: A total of 70 subjects were recruited in the study from the patients receiving treatment at the University of Illinois at Chicago’s orthodontic clinic. The inclusion criteria included subjects requiring extraction of maxillary first premolars as part of their comprehensive treatment with edgewise fixed appliances. Ultimately 11
GCF samples were collected from
healthy subjects between the ages 10 and 18 (mean 14.5 years old), who maintained excellent oral hygiene throughout the study.
GCF was collected using absorbent Periopaper strip at six timepoints.
T0: prior to bonding the fixed orthodontic appliances
T1: on the day of canine retraction
T2: 60 minutes after activating the power chain
T3: 1 day after the canine retraction visit
T4: 7 days after the canine retraction visit
T5: between 5 weeks after initiation of canine retraction
Human Let7d, g and i were used for normalization of secretory miRNA levels in
GCF. Wilcoxon Sign Rank and Kruskal-Wallis and Mann-Whitney U statistical analyses were used in this study
Results: In all studied miRNAs, the change in expression of miRNA from T1 to T5 showed statistical significance consistently (p-value ranging from 0.005 to 0.047). Changes between T1 and T2 were only observed in miRNA-29b. Changes between T1 and T4 were observed in both miRNA-101 and miRNA-29b. Analyzing all the time points together, Kruskal-Wallis test showed no statistical significant difference between miRNA-29a, miRNA-29b and miRNA-29c, (p>0.05, p-value ranging from 0.201 to 0.802) indicating the similarity in profile change of miRNA-29 family.
Conclusions: We concluded that secretory miRNAs exist in
GCF and the expression levels of miRNA-29 family change during orthodontic tooth movement.
Advisors/Committee Members: Atsawasuwan, Phimon (advisor), Evans, Carla (committee member), Viana, Maria Grace (committee member).
Subjects/Keywords: MicroRNA; MiRNA; GCF; orthodontics; orthodontic tooth movement; gingival crevicular fluid; biomarkers
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APA (6th Edition):
Lazari, P. (2016). Secretory Micro-RNA 29 in Gingival Crevicular Fluid During Canine Retraction. (Thesis). University of Illinois – Chicago. Retrieved from http://hdl.handle.net/10027/20907
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Lazari, Paul. “Secretory Micro-RNA 29 in Gingival Crevicular Fluid During Canine Retraction.” 2016. Thesis, University of Illinois – Chicago. Accessed April 15, 2021.
http://hdl.handle.net/10027/20907.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Lazari, Paul. “Secretory Micro-RNA 29 in Gingival Crevicular Fluid During Canine Retraction.” 2016. Web. 15 Apr 2021.
Vancouver:
Lazari P. Secretory Micro-RNA 29 in Gingival Crevicular Fluid During Canine Retraction. [Internet] [Thesis]. University of Illinois – Chicago; 2016. [cited 2021 Apr 15].
Available from: http://hdl.handle.net/10027/20907.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Lazari P. Secretory Micro-RNA 29 in Gingival Crevicular Fluid During Canine Retraction. [Thesis]. University of Illinois – Chicago; 2016. Available from: http://hdl.handle.net/10027/20907
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Toronto
2.
Ford, Heather Nicole.
Nitric Oxide Changes in Gingival Crevicular Fluid Following Orthodontic Force Application.
Degree: 2013, University of Toronto
URL: http://hdl.handle.net/1807/42838
► Nitric oxide (NO) plays a role in regulating the rate of orthodontic tooth movement (OTM) in rat models; however, in humans this role remains less…
(more)
▼ Nitric oxide (NO) plays a role in regulating the rate of orthodontic tooth movement (OTM) in rat models; however, in humans this role remains less clear. In this study, samples of gingival crevicular fluid (GCF) were collected from each maxillary central incisor and first and second molar immediately before (T0), 1 hour after (T1), and 3-4 days after (T2) application of light orthodontic forces in thirteen male participants (ages 11-18 years) undergoing orthodontic therapy. NO levels were measured in each GCF sample, and significantly higher NO levels (p<0.05) were found at T1 at the buccal surfaces of the central incisors when compared to the posterior teeth. The results indicate a possible role for NO in OTM at the pressure sites of incisors at early time points. Further studies are required to determine whether NO levels in the PDL of human teeth are affected by the magnitude of an applied force.
MAST
Advisors/Committee Members: Gong, Siew-Ging, Dentistry.
Subjects/Keywords: gingival crevicular fluid; griess reaction; GCF; orthodontic force application; nitric oxide; 0567
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APA (6th Edition):
Ford, H. N. (2013). Nitric Oxide Changes in Gingival Crevicular Fluid Following Orthodontic Force Application. (Masters Thesis). University of Toronto. Retrieved from http://hdl.handle.net/1807/42838
Chicago Manual of Style (16th Edition):
Ford, Heather Nicole. “Nitric Oxide Changes in Gingival Crevicular Fluid Following Orthodontic Force Application.” 2013. Masters Thesis, University of Toronto. Accessed April 15, 2021.
http://hdl.handle.net/1807/42838.
MLA Handbook (7th Edition):
Ford, Heather Nicole. “Nitric Oxide Changes in Gingival Crevicular Fluid Following Orthodontic Force Application.” 2013. Web. 15 Apr 2021.
Vancouver:
Ford HN. Nitric Oxide Changes in Gingival Crevicular Fluid Following Orthodontic Force Application. [Internet] [Masters thesis]. University of Toronto; 2013. [cited 2021 Apr 15].
Available from: http://hdl.handle.net/1807/42838.
Council of Science Editors:
Ford HN. Nitric Oxide Changes in Gingival Crevicular Fluid Following Orthodontic Force Application. [Masters Thesis]. University of Toronto; 2013. Available from: http://hdl.handle.net/1807/42838
University of Florida
3.
Mcneight, Angela Marie.
The Effect of Vibratory Stimulation and Tooth Movement on Gingival Crevicular Fluid Biomarkers.
Degree: MS, Dental Sciences - Dentistry, 2016, University of Florida
URL: https://ufdc.ufl.edu/UFE0050044
► In the field of orthodontics, gingival crevicular fluid (GCF) is one of the main targets for assessing biomarkers. The term GCF describes the fluid that…
(more)
▼ In the field of orthodontics,
gingival crevicular fluid (
GCF) is one of the main targets for assessing biomarkers. The term
GCF describes the
fluid that escapes from between the tooth surface and the epithelial lining of the periodontal ligament (PDL). There are over 100 regulatory proteins that can be detected in
GCF, and they can be categorized on the basis of their biological significance such as bone resorption or formation. OBJECTIVES: To investigate the effect of vibratory stimulation (AcceleDent(R) Aura) on the expression of biomarkers in
GCF using a human tooth movement model with clear aligners. METHODS: Prospective, single-center, randomized controlled crossover study comparing an active vibration device to a sham device. Participants received 6 Zendura(R) plastic aligners to move a target tooth 1.98 mm over 12 weeks. Patients were crossed over to the opposite device at the 4th aligner.
GCF was collected at T0 (baseline 1), T1 (baseline 2), T2 (week 1), T3 (week 7, crossover) and T4 (week 12). 11 biomarker levels quantified by multiplex bead immunoassay. A mixed model analysis was used to compare the effects of active versus sham device on
GCF composition. RESULTS: 16 males and 23 females completed the protocol. No statistically significant differences were found between the biomarker levels of the Sham-Active (SA Group) and Active-Sham (AS Group). The results of each group were then combined and biomarker concentrations were compared to tooth movement. There was a negative correlation between the baseline level of IL-6 and the total amount of tooth movement. A negative correlation was seen between the baseline levels of MMP-9 and tooth movement between weeks 1-2 followed by a positive correlation between the concentration of MMP-9 at T4 and the amount of tooth movement over the course of the study. CONCLUSIONS: The results suggest that vibration does not influence the secretion of
GCF biomarkers; nevertheless, tooth movement with clear aligners seems to alter the proteomic composition of
GCF. This study was registered on https://clinicaltrials.gov (ClinicalTrials.gov Identifier: NCT01962012). It was approved by the Western Institutional Review Board (WIRB20131856). This study was funded by OrthoAccel(R) Technologies. ( en )
Advisors/Committee Members: RODY,WELLINGTON JOSE,JR (committee chair), MCGORRAY,SUSAN P (committee member), WALLET,SHANNON MARGARET (committee member).
Subjects/Keywords: Biological markers; Bones; Gingival crevicular fluid; Orthodontics; Orthods; Osteoclasts; Rats; Statistical median; Tooth movement; Vibration; acceledent – crevicular – fluid – gcf – gingival – movement – orthodontics – tooth – vibration
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APA (6th Edition):
Mcneight, A. M. (2016). The Effect of Vibratory Stimulation and Tooth Movement on Gingival Crevicular Fluid Biomarkers. (Masters Thesis). University of Florida. Retrieved from https://ufdc.ufl.edu/UFE0050044
Chicago Manual of Style (16th Edition):
Mcneight, Angela Marie. “The Effect of Vibratory Stimulation and Tooth Movement on Gingival Crevicular Fluid Biomarkers.” 2016. Masters Thesis, University of Florida. Accessed April 15, 2021.
https://ufdc.ufl.edu/UFE0050044.
MLA Handbook (7th Edition):
Mcneight, Angela Marie. “The Effect of Vibratory Stimulation and Tooth Movement on Gingival Crevicular Fluid Biomarkers.” 2016. Web. 15 Apr 2021.
Vancouver:
Mcneight AM. The Effect of Vibratory Stimulation and Tooth Movement on Gingival Crevicular Fluid Biomarkers. [Internet] [Masters thesis]. University of Florida; 2016. [cited 2021 Apr 15].
Available from: https://ufdc.ufl.edu/UFE0050044.
Council of Science Editors:
Mcneight AM. The Effect of Vibratory Stimulation and Tooth Movement on Gingival Crevicular Fluid Biomarkers. [Masters Thesis]. University of Florida; 2016. Available from: https://ufdc.ufl.edu/UFE0050044
Freie Universität Berlin
4.
Saidowa, Asisa.
correlation coefficients between a modified Papilla Bleeding Index and the
amount of crevicular fluid in patients suffering from generalized aggressive
periodontitis.
Degree: 2011, Freie Universität Berlin
URL: https://refubium.fu-berlin.de/handle/fub188/11142
► The periodontitis is an inflammatory disease condition caused by a variety of oral microorganisms. A hyper reactive host response regulation is triggering the disease progression…
(more)
▼ The periodontitis is an inflammatory disease condition caused by a variety of
oral microorganisms. A hyper reactive host response regulation is triggering
the disease progression in a small part of the world wide population – around
10% at most – resulting either in a local or generalized aggressive form of
manifestation. Bleeding is a final act in a process of tissue and capillary
damage initiated by bacterial presence and modulated by pro-inflammatory
cytokines. Calibrated assignment of bleeding intensity as a parameter for the
severity of the disease is considered golden standard for diagnosing
gingivitis – an inflammatory condition restricted to the soft tissues.
Periodontal inflammation regularly causes attachment loss and is accompanied
by loss of alveolar bone and a phenomenon named “pocketing”. The severity of
this disease condition is currently characterized by assessing either the
probing pocket depths (PPD) or the attachment loss (AL). The evaluation of
bleeding tendency as Bleeding on Probing (BoP) is currently an additional
dichotomous finding. The aim of the present study was to assess the
suitability of a visual calibration of a Pocket Bleeding Index (PoB-Index) to
reflect the real inflammatory status of each single probed periodontal pocket.
By matching single grades of the index suggested – i.e. the single visually
assigned bleeding grades - with parameters such as bleeding duration (stop
watch) and amount of blood sampled by capillary tube correlation coefficients
were calculated. Correlations between PoB-Index and the probing depth and PoBI
and the amount of
gingival crevicular fluid (
GCF) sampled as exudates that
follow a gradient were calculated also to objectify the visual calibration of
bleeding intensity. The capillary dilatation is initiated as first step in a
cascade of inflammatory reactions in front of all clinical signs and results
in a measurable increase of the
GCF. Since periodontitis progresses
episodically, i.e. phases of activity are followed by phases of inactivity the
capillary dilatation follows the same pattern. The mean age of 17
participating patients recruited was 32 years; 10 of them were non-smokers
whereas 7 were smoking. All patients enrolled did not have any periodontitis
therapy or received any antibiotics prescribed for the last 12 months. All
patients underwent intensive instructions in oral hygiene repeatedly, thus the
allocated plaque index remained for the duration of the study < 25% (API <
25%). After completion of instrumentation (S/RP) all patients received
Amoxicillin (500 mg) and Metronidazol (250 mg) x 3 daily for 10 days per os
prescribed. The assessment of the study parameters was carried out at baseline
after completion of the initial therapy (before S/RP), at month 3, 6 and 9
past active therapy. In total 575 sites were evaluated and monitored. For
improving the reproducibility, all measurements were undertaken under equal
conditions in all patients. The statistically significant correlation between
the
GCF amount and the PoB-Index grades at baseline…
Advisors/Committee Members: [email protected] (contact), w (gender), Prof. Dr. A. Friedmann (firstReferee), Prof. Dr. T. Kocher (furtherReferee).
Subjects/Keywords: generalized aggressive periodontitis; Bleeding on Probing (BOP); Pocket Bleeding Index (PoBI); gingival crevicular fluid (GCF); 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
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APA ·
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Manager
APA (6th Edition):
Saidowa, A. (2011). correlation coefficients between a modified Papilla Bleeding Index and the
amount of crevicular fluid in patients suffering from generalized aggressive
periodontitis. (Thesis). Freie Universität Berlin. Retrieved from https://refubium.fu-berlin.de/handle/fub188/11142
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Saidowa, Asisa. “correlation coefficients between a modified Papilla Bleeding Index and the
amount of crevicular fluid in patients suffering from generalized aggressive
periodontitis.” 2011. Thesis, Freie Universität Berlin. Accessed April 15, 2021.
https://refubium.fu-berlin.de/handle/fub188/11142.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Saidowa, Asisa. “correlation coefficients between a modified Papilla Bleeding Index and the
amount of crevicular fluid in patients suffering from generalized aggressive
periodontitis.” 2011. Web. 15 Apr 2021.
Vancouver:
Saidowa A. correlation coefficients between a modified Papilla Bleeding Index and the
amount of crevicular fluid in patients suffering from generalized aggressive
periodontitis. [Internet] [Thesis]. Freie Universität Berlin; 2011. [cited 2021 Apr 15].
Available from: https://refubium.fu-berlin.de/handle/fub188/11142.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Saidowa A. correlation coefficients between a modified Papilla Bleeding Index and the
amount of crevicular fluid in patients suffering from generalized aggressive
periodontitis. [Thesis]. Freie Universität Berlin; 2011. Available from: https://refubium.fu-berlin.de/handle/fub188/11142
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
5.
Boräng, Jennifer.
Green tea inhibits proteolytic enzymes in GCF from patients with chronic periodontitis.
Degree: 2012, , Faculty of Odontology (OD)
URL: http://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-19944
► Kronisk parodontit orsakar vävnadsdestruktion till följd av matrixmetalloproteinasaktivitet. Dessa enzym härrör från värdcellerna och är en del av det immunologiska svaret på bakteriella virulensfaktorer.…
(more)
▼ Kronisk parodontit orsakar vävnadsdestruktion till följd av matrixmetalloproteinasaktivitet. Dessa enzym härrör från värdcellerna och är en del av det immunologiska svaret på bakteriella virulensfaktorer. Grönt te har studerats för sina hälsofrämjande egenskaper, som omfattar bland annat anti-inflammatoriska effekter. Effekten beror delvis på enzyminhibering av tepolyfenoler. Syftet med denna studie var att ytterligare undersöka den inhiberande effekten av grönt te, med fokus på enzymatisk aktivitet i gingivalvätska från patienter med parodontal sjukdom. Patienter med kronisk parodontit valdes ut för att delta i studien. Gingivalvätska extraherades med mikropipetter från patienternas gingivala sulci. Proverna behandlades med grönt te och jämfördes med obehandlade prover från samma försöksperson. Fluorescens proteasanalys med kasein som substrat utfördes på fjorton prover för att detektera skillnader i kaseinolytisk aktivitet. Zymogramanalys med användning av gelatin som substrat utfördes på fyra prover, för att undersöka skillnader i gelatinolytisk aktivitet och analysera molekylvikter för de olika enzymerna. Den fluorometriska analysen visade en signifikant lägre enzymaktivitet i prover med tillsatt grönt te jämfört med obehandlade prover (p<0.001). Zymogramanalysen visade en skillnad i enzymaktivitet som var mest uttalad i banden för molekylär vikt runt 255 kDa, analogt med komplex av matrixmetalloproteinas-9. Sammanfattningsvis har det i denna studie påvisats att grönt te har en hämmande effekt på kaseinolytisk aktivitet och en mindre, mer specifik, hämmande effekt på gelatinasaktivitet.
Chronic periodontitis involves tissue destruction by matrix metalloproteinase, derived from the host cells, as part of the immunological response to bacterial virulence factors. Green tea has been studied for its health promoting properties, which includes anti-inflammatory effects. The effect is in part due to enzyme inhibition by tea polyphenols. The aim of this study was to further investigate the inhibitory effect of green tea, focusing on enzymatic activity in gingival crevicular fluid from patients with periodontal disease. Patients with chronic periodontitis were selected for participation in the study. Gingival crevicular fluid was extracted with micropipettes from the gingival sulci of the patients. Samples were treated with green tea and compared with untreated samples from the same subject. Fluorescence protease assay with casein as substrate was made using fourteen samples for detecting differences in caseinolytic activity. Zymogram assay using gelatin as substrate was done using four samples to test gelatinolytic activity and analyse molecular weights of the different enzymes. The fluorometric assay showed a significantly lower enzyme activity in samples mixed with green tea than untreated samples (p<0.001). The zymogram assay showed a difference in band strength which was most pronounced in the bands of molecular weight around 255 kDA, analogous to complexes of matrix metalloproteinase-9. In conclusion,…
Subjects/Keywords: green tea; polyphenols; EGCg; GCF; gingival crevicular fluid; periodontitis; MMP; inhibition; enzyme; fluorescence assay; zymography; Medical and Health Sciences; Medicin och hälsovetenskap
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APA (6th Edition):
Boräng, J. (2012). Green tea inhibits proteolytic enzymes in GCF from patients with chronic periodontitis. (Thesis). , Faculty of Odontology (OD). Retrieved from http://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-19944
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Boräng, Jennifer. “Green tea inhibits proteolytic enzymes in GCF from patients with chronic periodontitis.” 2012. Thesis, , Faculty of Odontology (OD). Accessed April 15, 2021.
http://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-19944.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Boräng, Jennifer. “Green tea inhibits proteolytic enzymes in GCF from patients with chronic periodontitis.” 2012. Web. 15 Apr 2021.
Vancouver:
Boräng J. Green tea inhibits proteolytic enzymes in GCF from patients with chronic periodontitis. [Internet] [Thesis]. , Faculty of Odontology (OD); 2012. [cited 2021 Apr 15].
Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-19944.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Boräng J. Green tea inhibits proteolytic enzymes in GCF from patients with chronic periodontitis. [Thesis]. , Faculty of Odontology (OD); 2012. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-19944
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Minnesota
6.
Chatzopoulos, Georgios.
Sclerostin And WNT-5A Gingival Protein Levels In Chronic Periodontitis And Health.
Degree: MS, Dentistry, 2018, University of Minnesota
URL: http://hdl.handle.net/11299/198978
► Background: Wnt signaling is fundamental to a myriad of biological processes including embryogenesis, organogenesis and tumorigenesis. It drives the expression of important genes for the…
(more)
▼ Background: Wnt signaling is fundamental to a myriad of biological processes including embryogenesis, organogenesis and tumorigenesis. It drives the expression of important genes for the proliferation, differentiation, maturation and activity of osteoblast-lineage cells. Pathways associated with Wnt signaling are regulated by their physiological antagonists such as sclerostin (SOST) as well as Wnt-5a that play important roles in the pathophysiology of several inflammatory conditions. Objectives: To compare the levels of SOST, Wnt-5a and TNF-α between chronic periodontitis and periodontally healthy sites as well as to determine the correlation between clinical periodontal parameters and protein levels. Material and methods: In a cross-sectional assessment, 25 chronic periodontitis cases and 25 periodontally healthy controls were measured for probing pocket depth (PPD), clinical attachment level (CAL), bleeding on probing (BOP), plaque index (PI) and percentage of radiographic bone loss. Gingival crevicular fluid (GCF) was collected cross sectionally from one periodontitis (deepest pocket) and one healthy (shallowest pocket) site in each case, and from one randomly selected site in each control subject. The protein levels of SOST, Wnt-5a and TNF-α in GCF were measured by ELISA. The Shapiro-Wilk test was utilized to assess the normality of the distribution and non-parametric comparisons were performed. Results: Protein levels of SOST and Wnt-5a were similar between healthy and chronic periodontitis sites as well as the SOST levels between periodontally affected and healthy sites in the chronic periodontitis group (p > 0.05). Periodontally involved sites exhibited statistically significantly higher total Wnt-5a levels than the healthy sites in the periodontitis cases (p = 0.017). When the data were expressed as concentration, significant differences were found among the study groups (p-values range from < 0.001 to 0.003). Significant positive correlations were found between SOST and 1) full-mouth PPD (p = 0.044), CAL (p = 0.010), BOP (p = 0.035); 2) PPD of the sampled sites (p = 0.037); and 3) sites with PPD 4-6 mm (p = 0.018). A trend of a negative correlation was found between SOST and sites with a CAL 0-2 mm (p = 0.052). Among all included subjects, males showed a statistically significantly higher Wnt-5a levels than females (p = 0.031). Conclusions: Within the limitations of this cross-sectional study, sites with chronic periodontitis exhibited significantly elevated levels of Wnt-5a when compared to periodontally healthy sites in chronic periodontitis patients. No statistically significant association was found with SOST and TNF-α levels.
Subjects/Keywords: Cross-sectional; Dentistry; Gingival Crevicular Fluid; Periodontitis; Sclerostin; Wnt-5a
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APA ·
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APA (6th Edition):
Chatzopoulos, G. (2018). Sclerostin And WNT-5A Gingival Protein Levels In Chronic Periodontitis And Health. (Masters Thesis). University of Minnesota. Retrieved from http://hdl.handle.net/11299/198978
Chicago Manual of Style (16th Edition):
Chatzopoulos, Georgios. “Sclerostin And WNT-5A Gingival Protein Levels In Chronic Periodontitis And Health.” 2018. Masters Thesis, University of Minnesota. Accessed April 15, 2021.
http://hdl.handle.net/11299/198978.
MLA Handbook (7th Edition):
Chatzopoulos, Georgios. “Sclerostin And WNT-5A Gingival Protein Levels In Chronic Periodontitis And Health.” 2018. Web. 15 Apr 2021.
Vancouver:
Chatzopoulos G. Sclerostin And WNT-5A Gingival Protein Levels In Chronic Periodontitis And Health. [Internet] [Masters thesis]. University of Minnesota; 2018. [cited 2021 Apr 15].
Available from: http://hdl.handle.net/11299/198978.
Council of Science Editors:
Chatzopoulos G. Sclerostin And WNT-5A Gingival Protein Levels In Chronic Periodontitis And Health. [Masters Thesis]. University of Minnesota; 2018. Available from: http://hdl.handle.net/11299/198978
7.
Strozolkouki, Marcia Maria.
Marcadores de diagnóstico da doença periodontal.
Degree: 2016, Universidade Fernando Pessoa
URL: http://www.rcaap.pt/detail.jsp?id=oai:bdigital.ufp.pt:10284/5585
► A periodontite é uma patologia inflamatória, causada pela interação entre o biofilme bacteriano e a resposta imune do hospedeiro e é caracterizada pela degradação de…
(more)
▼ A periodontite é uma patologia inflamatória, causada pela interação entre o biofilme bacteriano e a resposta imune do hospedeiro e é caracterizada pela degradação de fibras colágenas do periodonto.
Os avanços científicos possibilitaram o desenvolvimento de novas técnicas que possibilitem o diagnóstico precoce da doença, ou seja, prevenir a perda de inserção e progressão da periodontite. O diagnóstico da doença periodontal baseia-se em parâmetros clínicos como profundidade de sondagem, perda de inserção, hemorragia a sondagem e exames radiográficos.
A análise dos biomarcadores presentes no fluido crevicular gengival (FCG) e saliva tem sido alvo de inúmeros artigos, uma vez que o fluido crevicular gengival (FCG) é composto de uma gama de biomarcadores celulares e moleculares.
O presente trabalho teve como objetivo fazer uma revisão narrativa da literatura publicada a cerca dos métodos utilizados para diagnóstico precoce e prognóstico dos processos patológicos que podem estar presentes no periodonto. Foi realizada uma pesquisa bibliográfica online entre Dezembro de 2015 e Maio de 2016, com o objetivo de fazer uma revisão bibliográfica acerca do tema. Não foi estabelecido restrição quanto a data de publicação.
Através da identificação da concentração de determinadas proteínas presentes no FCG é possível avaliar a atividade da doença periodontal e o prognóstico. Um importante número de marcadores como a elastase neutrofílica, prostaglandina E2, catepsinas, osteocalcina, -glucoronidase, colagenase, fosfatase alcalina, aspartato aminotransferase são citados (Genco et al., 1992).
De acordo com a literatura publicada pode-se concluir que há alguns marcadores promissores para o diagnóstico precoce e prognóstico da doença periodontal, entretanto, não há ainda um marcador que possa identificar a futura perda de inserção ou a suscetibilidade à doença periodontal. São necessários estudos longitudinais para melhor entendimento do papel dos biomarcadores do FCG.
The periodontitis is an inflammatory pathology, caused by the interaction between biofilm and the host immune response, and is characterized by the degradation of collagen fibers of the periodontal.
The scientific advances permit the development of new techniques that allow the early diagnosis of the disease, that is, prevent the loss of insertion and advancement of periodontitis. The diagnosis of periodontal disease is based on clinical parameters such as probing depth, attachment loss, probing bleeding and radiographic examinations.
Thus, periodontal research for decades, focusing on the analysis of biomarkers present in the gingival crevicular fluid (GCF) and saliva. Gingival crevicular fluid (GCF) is composed of an array of cellular and molecular biomarkers
This study aimed to do a narrative literature review published about the methods for early diagnosis and prognosis of disease processes that may be present in the periodontium. An online bibliographic search was conducted between December 2015 and May 2016, aiming to make a literature review about the subject. A…
Advisors/Committee Members: Lima, Cristina.
Subjects/Keywords: Periodontal disease; Gingival Crevicular fluid; Diagnosis; Biomarkers; Domínio/Área Científica::Ciências Médicas::Medicina Clínica
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APA (6th Edition):
Strozolkouki, M. M. (2016). Marcadores de diagnóstico da doença periodontal. (Thesis). Universidade Fernando Pessoa. Retrieved from http://www.rcaap.pt/detail.jsp?id=oai:bdigital.ufp.pt:10284/5585
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Strozolkouki, Marcia Maria. “Marcadores de diagnóstico da doença periodontal.” 2016. Thesis, Universidade Fernando Pessoa. Accessed April 15, 2021.
http://www.rcaap.pt/detail.jsp?id=oai:bdigital.ufp.pt:10284/5585.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Strozolkouki, Marcia Maria. “Marcadores de diagnóstico da doença periodontal.” 2016. Web. 15 Apr 2021.
Vancouver:
Strozolkouki MM. Marcadores de diagnóstico da doença periodontal. [Internet] [Thesis]. Universidade Fernando Pessoa; 2016. [cited 2021 Apr 15].
Available from: http://www.rcaap.pt/detail.jsp?id=oai:bdigital.ufp.pt:10284/5585.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Strozolkouki MM. Marcadores de diagnóstico da doença periodontal. [Thesis]. Universidade Fernando Pessoa; 2016. Available from: http://www.rcaap.pt/detail.jsp?id=oai:bdigital.ufp.pt:10284/5585
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Washington
8.
Bamashmous, Shatha.
Investigation of Chemokine and Microbiome Profiles in Gingival Health and Disease in Humans.
Degree: PhD, 2019, University of Washington
URL: http://hdl.handle.net/1773/44153
► Periodontal health is maintained by various host immune mechanisms. Neutrophils are a crucial component of health representing the first line of defense against microbial challenge.…
(more)
▼ Periodontal health is maintained by various host immune mechanisms. Neutrophils are a crucial component of health representing the first line of defense against microbial challenge. The migration and activation of these key effector cells in the gingiva are orchestrated by complex networks of host mediators called chemokines and cytokines. Recently, it has been shown that bacteria have an influential role in the immunomodulation of host mediators and hence host immune response. Indeed, dysregulation of the host immune response, as well as a dysbiosis of the oral microbial community, has been attributed to the pathogenesis of periodontal disease. However, the few investigations into the interaction between the subgingival microbial community and the host immune response have provided limited information to understand this relationship. Therefore, a full assessment of the host-bacterial interaction in health and disease is necessary to further our understandings of the etiology of periodontal disease and identify novel biomarkers of this disease. This thesis investigates the interaction of subgingival microbiome and the host immune response for both health and disease with disease defined as induced gingivitis. A comprehensive evaluation of forty major chemokines and inflammatory mediators in the
gingival crevicular fluid (
GCF) was achieved by multiplex immunoassay. In parallel, 16S rRNA next-generation sequencing was performed to characterize microbial community composition and structure. Lastly, neutrophil infiltration was assessed by myeloperoxidase (MPO) detection in the
GCF to correlate neutrophil recruitment with chemokine expression patterns. The cross-sectional study in healthy adolescents showed inter-individual variability in the chemokine expression patterns and the subgingival microbial profile. Two different chemokine expression patterns were observed among study participants; however, the different groups did not share common microbiome profiles. Additionally, there was no significant concordance between the combined chemokines and microbial profiles in
gingival health. Altogether, this data provides a better understanding of the interaction between the immune response and microbiome in the state of clinical health. Findings from the experimental gingivitis study demonstrated that during the initial transition from clinical health to gingivitis, there was a significant shift in the microbial composition that paralleled an alteration in host homeostasis. Despite variable immune responses to plaque accumulation, this alteration was characterized by a decrease in neutrophil chemotactic factors within most patients. Furthermore, patients were able to be separated into three distinct categories with unique microbial and chemokine profiles based on their immune response. The result of this work highlights the influential effect of host response and microbiome in the susceptibility to periodontal disease. In conclusion, this study contributes to our understanding of the host-bacterial interaction in health and…
Advisors/Committee Members: Darveau, Richard P. (advisor).
Subjects/Keywords: Chemokine; Gingival crevicular fluid; Gingivitis; Microbiome; Neutrophil; Plaque; Dentistry; Microbiology; Immunology; Dentistry
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APA (6th Edition):
Bamashmous, S. (2019). Investigation of Chemokine and Microbiome Profiles in Gingival Health and Disease in Humans. (Doctoral Dissertation). University of Washington. Retrieved from http://hdl.handle.net/1773/44153
Chicago Manual of Style (16th Edition):
Bamashmous, Shatha. “Investigation of Chemokine and Microbiome Profiles in Gingival Health and Disease in Humans.” 2019. Doctoral Dissertation, University of Washington. Accessed April 15, 2021.
http://hdl.handle.net/1773/44153.
MLA Handbook (7th Edition):
Bamashmous, Shatha. “Investigation of Chemokine and Microbiome Profiles in Gingival Health and Disease in Humans.” 2019. Web. 15 Apr 2021.
Vancouver:
Bamashmous S. Investigation of Chemokine and Microbiome Profiles in Gingival Health and Disease in Humans. [Internet] [Doctoral dissertation]. University of Washington; 2019. [cited 2021 Apr 15].
Available from: http://hdl.handle.net/1773/44153.
Council of Science Editors:
Bamashmous S. Investigation of Chemokine and Microbiome Profiles in Gingival Health and Disease in Humans. [Doctoral Dissertation]. University of Washington; 2019. Available from: http://hdl.handle.net/1773/44153
The Ohio State University
9.
Jain, Nidhi.
Gingival crevicular fluid concentrations of azithromycin in
health and gingivitis.
Degree: MS, Dentistry, 2011, The Ohio State University
URL: http://rave.ohiolink.edu/etdc/view?acc_num=osu1306783019
► Azithromycin, a macrolide antibiotic is active against several periodontal pathogens, is taken up and concentrated inside gingival fibroblasts, oral epithelium and polymorphonuclear leucocytes. Interactions with…
(more)
▼ Azithromycin, a macrolide antibiotic is active against
several periodontal pathogens, is taken up and concentrated inside
gingival fibroblasts, oral epithelium and polymorphonuclear
leucocytes. Interactions with host cells in gingiva could influence
the pharmacokinetics of this agent in periodontal applications.
This issue was examined in two separate clinical studies. The first
study, described in Chapter 2, tested the hypothesis that
steady-state concentrations of azithromycin are higher and more
sustained in
gingival crevicular fluid (
GCF) than in serum. Four
healthy subjects received an initial dose of 500 mg azithromycin
followed by 250 mg doses on each of the next 2 days. Serum and
GCF
samples were obtained 2 hours after the last dose and on days 4 and
7.
GCF samples were collected from maxillary posterior
interproximal sites with paper strips. The strips were pooled and
eluted with high purity water. After extraction with diethyl ether,
the azithromycin content of the serum samples and
GCF eluates was
determined with an agar diffusion bioassay. On days 2, 4 and 7, the
concentrations of azithromycin in blood serum were 0.22 ± 0.02,
0.08 ± 0.02 and 0.04 ± 0.01 µg/ml, respectively. The concentrations
in
GCF were 8.82 ± 1.25, 7.90 ± 1.72 and 7.38 ± 1.15 µg/ml,
respectively. Mean
GCF levels were consistently higher than mean
serum levels. The findings demonstrate that the pharmacokinetic
profiles of azithromycin are different in
GCF and serum. At steady
state, azithromycin concentrations in
GCF were higher and more
sustained than those in serum. Based on previous studies, the
levels observed in
GCF were above the Minimum Inhibitory
Concentration for Aggregatibacter actinomycetemcomitans,
Porphyromonas gingivalis, and Prevotella intermedia.Azithromycin
preferentially localizes in inflamed tissues, suggesting that its
concentration in
gingival crevicular fluid could be higher at
gingivitis sites than in health. The study described in chapter 3
tested this hypothesis. Experimental gingivitis was induced in one
maxillary posterior sextant in nine healthy subjects. Contralateral
healthy sextants served as controls. Subjects took 500 mg of
azithromycin followed by 250 mg 24 hours later. Four hours after
the second dose, plaque was removed from the gingivitis sites.
GCF
was collected from 8 surfaces in both the gingivitis and control
sextants and pooled separately.
GCF samples were subsequently
collected on days 1, 2, 3, 8 and 15 and their azithromycin content
was determined with the bioassay procedure described in Chapter 2.
On days 2 and 3, the pooled
GCF volume at gingivitis sites was
significantly higher than at control sites and the mean
azithromycin content in 30 second
GCF samples pooled from
gingivitis sites was significantly higher than at control sites.
However, there were no significant differences in
GCF azithromycin
concentration between the gingivitis and control pools at any
point. Thus, the amount of azithromycin perfusing gingivitis sites
is greater than at healthy sites, but its concentration in
GCF is…
Advisors/Committee Members: Walters, John (Advisor).
Subjects/Keywords: Dentistry; azithromycin; gingival crevicular fluid; gingivitis
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APA (6th Edition):
Jain, N. (2011). Gingival crevicular fluid concentrations of azithromycin in
health and gingivitis. (Masters Thesis). The Ohio State University. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=osu1306783019
Chicago Manual of Style (16th Edition):
Jain, Nidhi. “Gingival crevicular fluid concentrations of azithromycin in
health and gingivitis.” 2011. Masters Thesis, The Ohio State University. Accessed April 15, 2021.
http://rave.ohiolink.edu/etdc/view?acc_num=osu1306783019.
MLA Handbook (7th Edition):
Jain, Nidhi. “Gingival crevicular fluid concentrations of azithromycin in
health and gingivitis.” 2011. Web. 15 Apr 2021.
Vancouver:
Jain N. Gingival crevicular fluid concentrations of azithromycin in
health and gingivitis. [Internet] [Masters thesis]. The Ohio State University; 2011. [cited 2021 Apr 15].
Available from: http://rave.ohiolink.edu/etdc/view?acc_num=osu1306783019.
Council of Science Editors:
Jain N. Gingival crevicular fluid concentrations of azithromycin in
health and gingivitis. [Masters Thesis]. The Ohio State University; 2011. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=osu1306783019
Universidade do Estado do Rio de Janeiro
10.
Tatiane Flôr Coelho de Souza Breves Beiler.
Expressão do interferon-γ em biópsias gengivais de pacientes com periodontite crônica severa.
Degree: Master, 2014, Universidade do Estado do Rio de Janeiro
URL: http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=6637
;
► O objetivo desse estudo foi analisar a expressão do interferon-gamma (INF-) em biópsias gengivais de sítios rasos e profundos de pacientes com periodontite crônica severa.…
(more)
▼ O objetivo desse estudo foi analisar a expressão do interferon-gamma (INF-) em biópsias gengivais de sítios rasos e profundos de pacientes com periodontite crônica severa. O objetivo secundário foi correlacionar a expressão do INF- no fluido gengival com os sítios onde foram coletadas as biópsias gengivais. Foram coletadas biópsias de 22 pacientes portadores de periodontite crônica generalizada ou localizada severas (idade média 45,5 DP 8,9 anos), sendo 22 sítios profundos e 18 sítios rasos. O grupo controle foi composto por 14 pacientes clinicamente saudáveis (idade média 39,35 DP 16,5 anos). No total, foram 54 biópsias coletadas de 36 pacientes. As amostras do fluido gengival foram coletadas de alguns dos mesmos sítios de onde foram realizadas as biópsias, totalizando 12 sítios profundos, 8 sítios rasos e 4 sítios controle. Foram utilizados os parâmetros clínicos de avaliação de profundidade de bolsa à sondagem (PB); nível de inserção clínica (NIC); índice de placa visível (IPV) e índice de sangramento gengival (ISG). O tecido foi removido com punch de 2 mm de diâmetro, na área cirúrgica (grupo controle) ou na consulta para raspagem subgengival com ou sem acesso cirúrgico (grupo teste) e armazenados em Eppendorffs com 1 ml de solução de formaldeído a 10% para posterior análise morfológica e imuno-histoquímica. A intensidade da marcação do INF- foi avaliada semiquantitativamente nas células epiteliais, plasmócitos, macrófagos, fibroblastos e células endoteliais, considerando-se marcação forte (escore 2), marcação fraca (escore 1) ou ausência de marcação (escore 0). O teste de Kruskal-Wallis foi utilizado para comparar a expressão do INF- nos tecidos epitelial e conjuntivo, entre os três grupos (sítios profundos e rasos da periodontite e sítios controle). Observamos uma tendência a um padrão de marcação similar nos sítios rasos e profundos, com predomínio de marcação fraca nos sítios profundos. Nos sítios controle a marcação do epitélio demonstrou ser predominante. Porém, não foi possível demonstrar diferenças estatisticamente significativas entre a expressão do INF- nos tecidos epitelial e conjuntivo nos grupos analisados. A análise da correlação de Spearman revelou uma forte correlação entre a expressão imuno-histoquímica do INF- no epitélio com macrófagos, fibroblastos e células endoteliais (r ≥ 0,6 e p ≤ 0,01). A expressão do INF- nos tecidos demostrou não ter correlação significante com os dados clínicos apresentados e com o fluido gengival. Concluímos que não foi possível observar diferenças na expressão do INF- em biópsias gengivais nos sítios rasos e profundos de pacientes com periodontite quando comparados à indivíduos saudáveis, o que pode ser atribuído ao caráter bifásico do INF-. A baixa detecção do INF- no fluido gengival, dentro das limitações do estudo, pode sugerir que este talvez não seja o método de eleição para a detecção do INF-Y.
The aim of this study was to analyze the expression of…
Advisors/Committee Members: Fabio Ramoa Pires, Ricardo Guimarães Fischer, Carlos Marcelo da Silva Figueredo, Magali Silveira Monteiro Ribeiro, Vívian de Carvalho Miceli.
Subjects/Keywords: Interferon-γ; Periodontite crônica; Biópsias gengivais; Fluido gengival; Imuno-histoquímica; Interferon-γ; Chronic periodontitis; Gingival biopsies; Gingival crevicular fluid; Immunohistochemistry; ODONTOLOGIA
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APA ·
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APA (6th Edition):
Beiler, T. F. C. d. S. B. (2014). Expressão do interferon-γ em biópsias gengivais de pacientes com periodontite crônica severa. (Masters Thesis). Universidade do Estado do Rio de Janeiro. Retrieved from http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=6637 ;
Chicago Manual of Style (16th Edition):
Beiler, Tatiane Flôr Coelho de Souza Breves. “Expressão do interferon-γ em biópsias gengivais de pacientes com periodontite crônica severa.” 2014. Masters Thesis, Universidade do Estado do Rio de Janeiro. Accessed April 15, 2021.
http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=6637 ;.
MLA Handbook (7th Edition):
Beiler, Tatiane Flôr Coelho de Souza Breves. “Expressão do interferon-γ em biópsias gengivais de pacientes com periodontite crônica severa.” 2014. Web. 15 Apr 2021.
Vancouver:
Beiler TFCdSB. Expressão do interferon-γ em biópsias gengivais de pacientes com periodontite crônica severa. [Internet] [Masters thesis]. Universidade do Estado do Rio de Janeiro; 2014. [cited 2021 Apr 15].
Available from: http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=6637 ;.
Council of Science Editors:
Beiler TFCdSB. Expressão do interferon-γ em biópsias gengivais de pacientes com periodontite crônica severa. [Masters Thesis]. Universidade do Estado do Rio de Janeiro; 2014. Available from: http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=6637 ;
11.
Ikuta, Takahisa.
Gene polymorphism of β-defensin-1 is associated with susceptibility to periodontitis in Japanese : 日本人歯周病患者におけるβ-ディフェシン-１の遺伝子多型と疾患感受性に関する研究.
Degree: 博士（歯学）, 2014, Tokushima University / 徳島大学
URL: http://repo.lib.tokushima-u.ac.jp/106075
Subjects/Keywords: periodontitis; SNP; β-defensin-1; lactoferrin; gingival crevicular fluid
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APA (6th Edition):
Ikuta, T. (2014). Gene polymorphism of β-defensin-1 is associated with susceptibility to periodontitis in Japanese : 日本人歯周病患者におけるβ-ディフェシン-１の遺伝子多型と疾患感受性に関する研究. (Thesis). Tokushima University / 徳島大学. Retrieved from http://repo.lib.tokushima-u.ac.jp/106075
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Ikuta, Takahisa. “Gene polymorphism of β-defensin-1 is associated with susceptibility to periodontitis in Japanese : 日本人歯周病患者におけるβ-ディフェシン-１の遺伝子多型と疾患感受性に関する研究.” 2014. Thesis, Tokushima University / 徳島大学. Accessed April 15, 2021.
http://repo.lib.tokushima-u.ac.jp/106075.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Ikuta, Takahisa. “Gene polymorphism of β-defensin-1 is associated with susceptibility to periodontitis in Japanese : 日本人歯周病患者におけるβ-ディフェシン-１の遺伝子多型と疾患感受性に関する研究.” 2014. Web. 15 Apr 2021.
Vancouver:
Ikuta T. Gene polymorphism of β-defensin-1 is associated with susceptibility to periodontitis in Japanese : 日本人歯周病患者におけるβ-ディフェシン-１の遺伝子多型と疾患感受性に関する研究. [Internet] [Thesis]. Tokushima University / 徳島大学; 2014. [cited 2021 Apr 15].
Available from: http://repo.lib.tokushima-u.ac.jp/106075.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Ikuta T. Gene polymorphism of β-defensin-1 is associated with susceptibility to periodontitis in Japanese : 日本人歯周病患者におけるβ-ディフェシン-１の遺伝子多型と疾患感受性に関する研究. [Thesis]. Tokushima University / 徳島大学; 2014. Available from: http://repo.lib.tokushima-u.ac.jp/106075
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Universidade do Estado do Rio de Janeiro
12.
Bruno Rescala Conde de Medeiros.
Perfil imunológico e microbiológico de pacientes com periodontites crônica e agressiva.
Degree: PhD, 2010, Universidade do Estado do Rio de Janeiro
URL: http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=2577
;
► O objetivo deste estudo foi determinar os níveis de interleucina-1β (IL-1 β), IL-2, IL-4, IL-8, interferon-γ (IFN-γ) e a atividade de elastase no fluido gengival…
(more)
▼ O objetivo deste estudo foi determinar os níveis de interleucina-1β (IL-1 β), IL-2, IL-4, IL-8, interferon-γ (IFN-γ) e a atividade de elastase no fluido gengival (FG) de pacientes com periodontite crônica generalizada (PCG) e periodontite agressiva generalizada (PAgG), e correlacionar com indivíduos de um grupo controle com gengivite apenas. Um objetivo secundário foi analisar o perfil microbiológico subgengival destes indivíduos. Dados clínicos transversais foram obtidos de 20 pacientes com PCG, 17 pacientes com PAgG e 10 indivíduos com gengivite. Amostras de FG foram coletadas com tiras de papel e os níveis de: IL-1β, IL-2, IL-4, IL-8 e IFN-γ foram medidos, utilizando um imunoensaio do tipo multiplex (Luminex). Atividade da elastase foi avaliada por um ensaio enzimático. Amostras de placa subgengival foram analisadas através do checkerboard DNA-DNA hybridization. As diferenças de significância entre os grupos para dados imunológicos e microbiológicos foram realizadas utilizando o teste Kruskal-Wallis, ajustando para múltiplas comparações. As médias dos parâmetros clínicos e os volumes de FG foram maiores nos pacientes com PCG e PAgG comparados ao grupo gengivite. Níveis mais elevados de IL-1β e atividade de elastase foram encontrados em sítios profundos quando comparado a sítios rasos em ambos os grupos com periodontite (p <0,05). Os dados microbiológicos apresentaram níveis significativamente mais elevados das espécies do complexo vermelho em pacientes com PCG e PAgG, quando comparados aos indivíduos com gengivite (p <0,05). Não houve diferença estatisticamente significante nos níveis de biomarcadores no FG e nos níveis de espécies bacterianas subgengivais entre pacientes com PCG e pacientes com PAgG. Sendo assim, concluímos que os dados do presente estudo não mostraram diferença estatisticamente significante nos parâmetros imunológicos e microbiológicos medidos entre indivíduos com PCG e PAgG.
The goal of this study was to determine the gingival crevicular fluid (GCF) levels of interleukin-1β (IL-1β), IL-2, IL-4, IL-8 and interferon-γ (IFN-γ) and elastase activity from patients with generalized chronic (GCP) and generalized aggressive periodontitis (GAgP) and to compare with a control group with gingivitis subjects. A secondary aim was to analyze the microbiological profile of these subjects. Cross-sectional clinical data were obtained from 20 GCP, 17 GAgP and 10 gingivitis subjects. GCF samples were collected with paper strips and the levels of: IL-1β, IL-2, IL-4, IL-8, and IFN-γ measured using a multiplexed bead immunoassay (Luminex). Elastase activity was assessed by an enzymatic assay. Subgingival plaque samples were analyzed using checkerboard DNA-DNA hybridization. Significance of differences among groups for immunological and microbiological data was examined using Kruskal-Wallis adjusting for multiple comparisons. Mean clinical parameters and GCF volumes were higher in GCP and GAgP patients compared to controls. Higher levels of…
Advisors/Committee Members: Jonas Capelli Júnior, Raphael Hirata Júnior, Ricardo Guimarães Fischer, Carlos Marcelo da Silva Figueredo, Ricardo Palmier Teles, Milton de Uzeda.
Subjects/Keywords: Periodontite; Fluido do sulco gengival; Citocinas; Microbiologia; Periodontitis; Gingival crevicular fluid; Cytokines; Microbiology; PERIODONTIA; Periodontite - Tratamento; Biofilme - Microbiologia
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APA (6th Edition):
Medeiros, B. R. C. d. (2010). Perfil imunológico e microbiológico de pacientes com periodontites crônica e agressiva. (Doctoral Dissertation). Universidade do Estado do Rio de Janeiro. Retrieved from http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=2577 ;
Chicago Manual of Style (16th Edition):
Medeiros, Bruno Rescala Conde de. “Perfil imunológico e microbiológico de pacientes com periodontites crônica e agressiva.” 2010. Doctoral Dissertation, Universidade do Estado do Rio de Janeiro. Accessed April 15, 2021.
http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=2577 ;.
MLA Handbook (7th Edition):
Medeiros, Bruno Rescala Conde de. “Perfil imunológico e microbiológico de pacientes com periodontites crônica e agressiva.” 2010. Web. 15 Apr 2021.
Vancouver:
Medeiros BRCd. Perfil imunológico e microbiológico de pacientes com periodontites crônica e agressiva. [Internet] [Doctoral dissertation]. Universidade do Estado do Rio de Janeiro; 2010. [cited 2021 Apr 15].
Available from: http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=2577 ;.
Council of Science Editors:
Medeiros BRCd. Perfil imunológico e microbiológico de pacientes com periodontites crônica e agressiva. [Doctoral Dissertation]. Universidade do Estado do Rio de Janeiro; 2010. Available from: http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=2577 ;
Universidade do Estado do Rio de Janeiro
13.
Cristiane Canavarro Rodrigues Martins.
Avaliação dos níveis de metaloproteinases da matriz no fluido gengival durante a movimentação dentária ortodôntica.
Degree: PhD, 2010, Universidade do Estado do Rio de Janeiro
URL: http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=2907
;
► Durante o tratamento ortodôntico, a resposta inicial dos tecidos periodontais ao estímulo mecânico envolve várias alterações estruturais e bioquímicas que permitem a movimentação do dente.…
(more)
▼ Durante o tratamento ortodôntico, a resposta inicial dos tecidos periodontais ao estímulo mecânico envolve várias alterações estruturais e bioquímicas que permitem a movimentação do dente. As metaloproteinases da matriz (MMPs) parecem desempenhar um papel importante na manutenção da integridade funcional da matriz extracelular periodontal. O objetivo do presente estudo foi avaliar, em diferentes intervalos de tempo, os níveis de metaloproteinases da matriz -1, -2, -3, -7, -8, -12 e -13 no fluido gengival (FG) de caninos superiores submetidos ao movimento de distalização e testar a hipótese de possíveis alterações nos níveis destas MMPs com o emprego de forças ortodônticas. Amostras de FG foram obtidas de dezesseis pacientes ortodônticos saudáveis (nove do sexo masculino e sete do sexo feminino, com idades entre 13 e 27 anos, média de idade 17,7 anos) que possuíam indicação de exodontias dos primeiros pré-molares superiores e tiveram os caninos distalizados como parte da terapia ortodôntica. Um dos caninos superiores foi distalizado ortodonticamente, sendo considerado dente teste. O canino contralateral não foi submetido a nenhuma força, no entanto foi incluído na aparatologia ortodôntica e utilizado como controle. A coleta de FG foi realizada nos sítios mesial (tensão) e distal (pressão) dos dentes testes e controles 7 dias antes da montagem da aparatologia ortodôntica, imediatamennte após a aplicação da força ortodôntica, e após 1 h, 24 h, e 7, 14 e 21 dias, respectivamente denominados -7d, 0h, 1h, 24h, 7d, 14d e 21d. A arcada superior de cada paciente foi dividida em um lado teste e um lado controle. Os resultados mostraram que foram encontradas diferenças significativas no volume do FG apenas nos intervalos de tempo entre -7d e 0h nos lados controle-pressão (CP), teste-tensão (TT) e teste-pressão (TP). Em TP foi observado ainda aumento do volume entre os tempos 0h e 14d. Foi possível detectar no FG as MMPs estudadas nos lados controle/teste e lados pressão/tensão, em todos os intervalos de tempo. As flutuações dos níveis das MMPs apresentaram poucas alterações significativas nos diferentes intervalos de tempo, nos lados controle/teste e lados pressão/ tensão. As diferenças intergrupos (TT, TP, CT e CP) em cada tempo não mostraram resultados significativos assim como as comparações entre os lados pressão e tensão para cada tempo individualmente. Os níveis de expressão da MMP-8 foram muito superiores aos das outras MMPs avaliadas, porém sem diferenças signficativas entre os lados teste e controle.
During orthodontic treatment, the initial response of periodontal tissues to mechanical stress involves several structural and biochemical changes that allow the tooth movement. The matrix metalloproteinases (MMPs) seem to play an important role in maintaining the functional integrity of periodontal extracellular matrix. The aim of this study was to evaluate, in different periods, the levels of matrix metalloproteinases -1, -2, -3, -7, -8, -12 and -13 in gingival crevicular fluid (GCF) of the superior caninessubmitted…
Advisors/Committee Members: Marco Antonio de Oliveira Almeida, Jonas Capelli Júnior, Raphael Hirata Júnior, José Nelson Mucha, Carlos Marcelo da Silva Figueredo, Ricardo Palmier Teles, Robert Willer Farinazzo Vitral.
Subjects/Keywords: Metaloproteinases da matriz; Periodonto; Fluido do sulco gengival; Movimentação dentária; Ortodontia; Matrix metalloproteinases; Periodontium; Gingival crevicular fluid; Tooth movement; Orthodontics; ORTODONTIA
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APA (6th Edition):
Martins, C. C. R. (2010). Avaliação dos níveis de metaloproteinases da matriz no fluido gengival durante a movimentação dentária ortodôntica. (Doctoral Dissertation). Universidade do Estado do Rio de Janeiro. Retrieved from http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=2907 ;
Chicago Manual of Style (16th Edition):
Martins, Cristiane Canavarro Rodrigues. “Avaliação dos níveis de metaloproteinases da matriz no fluido gengival durante a movimentação dentária ortodôntica.” 2010. Doctoral Dissertation, Universidade do Estado do Rio de Janeiro. Accessed April 15, 2021.
http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=2907 ;.
MLA Handbook (7th Edition):
Martins, Cristiane Canavarro Rodrigues. “Avaliação dos níveis de metaloproteinases da matriz no fluido gengival durante a movimentação dentária ortodôntica.” 2010. Web. 15 Apr 2021.
Vancouver:
Martins CCR. Avaliação dos níveis de metaloproteinases da matriz no fluido gengival durante a movimentação dentária ortodôntica. [Internet] [Doctoral dissertation]. Universidade do Estado do Rio de Janeiro; 2010. [cited 2021 Apr 15].
Available from: http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=2907 ;.
Council of Science Editors:
Martins CCR. Avaliação dos níveis de metaloproteinases da matriz no fluido gengival durante a movimentação dentária ortodôntica. [Doctoral Dissertation]. Universidade do Estado do Rio de Janeiro; 2010. Available from: http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=2907 ;
Universidade do Estado do Rio de Janeiro
14.
Rhita Cristina Cunha Almeida.
Efeito do movimento dentário nos níveis de metaloproteinases da matriz no fluido gengival de pacientes com periodontite controlada.
Degree: PhD, 2012, Universidade do Estado do Rio de Janeiro
URL: http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=7216
;
► O objetivo deste trabalho foi examinar o impacto da movimentação dentária de dentes periodontalmente comprometidos no volume do fluido gengival crevicular (FGC) e nos níveis…
(more)
▼ O objetivo deste trabalho foi examinar o impacto da movimentação dentária de dentes periodontalmente comprometidos no volume do fluido gengival crevicular (FGC) e nos níveis de expressão das metaloproteinases de matriz (MMPs) -1, -2, -3, -7, -8, -12 e -13 no FGC. Dez pacientes periodontalmente controlados (8 do sexo feminino e 2 do sexo masculino, média de idade de 46,2 10,4 anos) com incisivos projetados labialmente foram submetidos a tratamento ortodôntico. Uma arcada dentária foi submetida a movimentação ortodôntica e a arcada oposta foi usada como controle. Amostras de FGC foram coletadas da face lingual de dois incisivos do lado movimento e dois do lado controle uma semana antes da ativação ortodôntica (-7d), imediatamente após a ativação ortodôntica, e após 1 h, 24 h, e 7, 14 e 21 dias. A coleta do FGC foi feita utilizando-se tiras de papel absorvente e o volume foi calculado através do uso do Periotron. Todos os pacientes receberam orientações de higiene bucal e um kit contendo escova de dente, pasta de dente e bochecho de Chlorexidina 0,12% para ser usado durante todo o experimento. A técnica da multianálise imunoenzimática com microesferas foi usada para medir as MMPs no FGC. Os dados foram analisados utilizando-se os testes estatísticos Friedman e Mann-Whitney. Não foram encontradas diferenças estatisticamente significativas no volume do FGC. Em relação aos níveis de MMPs, a única diferença estatisticamente significativa encontrada no decorrer do tempo foi nos níveis de MMP-1 no grupo movimento (p<0,05). Quando os dois grupos foram comparados após a ativação, a única diferença estatisticamente significativa encontrada foi nos níveis de MMP-12 24 horas após a ativação (p<0,05). Estes achados sugerem que o volume de FGC não sofre alteração relacionada ao movimento dentário ortodôntico e que o movimento ortodôntico de dentes periodontalmente comprometidos não resultou em mudanças significativas nos níveis de MMPs no FGC.
The aim of this study was to evaluate whether orthodontic tooth movement of periodontally compromised teeth would result in detectable changes in gingival crevicular fluid (GCF) volume and in the levels of matrix metalloproteinases (MMP) -1, -2, -3, -7, -8, -12 and -13 in the GCF. Ten controlled periodontitis subjects (8 females and 2 males, mean age of 46.2 10.4 years) with flared incisors were submitted to orthodontic treatment. One dental arch was subjected to orthodontic movement, and teeth in the opposite arch were used as controls. GCF samples were collected from the lingual sites of two test and two control incisors one week before orthodontic activation (-7d), immediately after orthodontic activation, and after 1 h, 24 h, and 7, 14 and 21 days. Filter paper strips were used in combination with a Periotron for GCF volume measurements. All patients received hygiene instructions and a kit containing toothbrush, fluoride dentifrice and gluconate chlorexidine 0.12% mouthwash to be used during all experiment. Multiplexed bead immunoassay was used to measure MMPs in GCF. Data were…
Advisors/Committee Members: Jonas Capelli Júnior, Raphael Hirata Júnior, José Nelson Mucha, Telma Martins de Araujo, Flavia Raposo Gebara Artese, Ricardo Guimarães Fischer, Ricardo Palmier Teles.
Subjects/Keywords: Metaloproteinases da matriz; ODONTOLOGIA; Movimentação dentária; Líquido do sulco gengival; Matrix metalloproteinases. Tooth movement. Gingival crevicular fluid
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APA ·
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MLA ·
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APA (6th Edition):
Almeida, R. C. C. (2012). Efeito do movimento dentário nos níveis de metaloproteinases da matriz no fluido gengival de pacientes com periodontite controlada. (Doctoral Dissertation). Universidade do Estado do Rio de Janeiro. Retrieved from http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=7216 ;
Chicago Manual of Style (16th Edition):
Almeida, Rhita Cristina Cunha. “Efeito do movimento dentário nos níveis de metaloproteinases da matriz no fluido gengival de pacientes com periodontite controlada.” 2012. Doctoral Dissertation, Universidade do Estado do Rio de Janeiro. Accessed April 15, 2021.
http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=7216 ;.
MLA Handbook (7th Edition):
Almeida, Rhita Cristina Cunha. “Efeito do movimento dentário nos níveis de metaloproteinases da matriz no fluido gengival de pacientes com periodontite controlada.” 2012. Web. 15 Apr 2021.
Vancouver:
Almeida RCC. Efeito do movimento dentário nos níveis de metaloproteinases da matriz no fluido gengival de pacientes com periodontite controlada. [Internet] [Doctoral dissertation]. Universidade do Estado do Rio de Janeiro; 2012. [cited 2021 Apr 15].
Available from: http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=7216 ;.
Council of Science Editors:
Almeida RCC. Efeito do movimento dentário nos níveis de metaloproteinases da matriz no fluido gengival de pacientes com periodontite controlada. [Doctoral Dissertation]. Universidade do Estado do Rio de Janeiro; 2012. Available from: http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=7216 ;
Univerzitet u Beogradu
15.
Perunović, Neda Đ., 1982-.
Nivoi IL-1β , IL-6, TNF-α, PGE2 u gingivalnoj tečnosti i
u krvi prevremeno porođenih žena sa parodontitisom.
Degree: Stomatološki fakultet, 2016, Univerzitet u Beogradu
URL: https://fedorabg.bg.ac.rs/fedora/get/o:10744/bdef:Content/get
► Stomatologija - Parodontologija / Dental medicine - Periodontology
Uvod. Prevremeni porođaj se definiše kao onaj porođaj koji se dogodi pre navršene 37. nedelje gestacije. Prevremeni…
(more)
▼ Stomatologija - Parodontologija / Dental medicine -
Periodontology
Uvod. Prevremeni porođaj se definiše kao onaj
porođaj koji se dogodi pre navršene 37. nedelje gestacije.
Prevremeni porođaj se smatra značajnim uzrokom perinatalnog
morbiditeta i važnim činiocem perinatalnog mortaliteta.
Prostaglandin E2 (PGE2), interleukin-1β (IL-1β), interleukin-6 i
faktor nekroze tumora alfa (TNF-α) su medijatori zapaljenja koji su
označeni i kao biohemijski markeri - prediktori porođaja. Nivoi
ovih medijatora zapaljenja se postepeno povećavaju tokom trudnoće i
postizanje njihovih kritičnih vrednosti dovodi do započinjanja
porođaja. Pretpostavka je da postojanje udaljene infekcije koja ima
elemente imunskog odgovora slične prevremenom porođaju, usled
sposobnosti da naruši lokalnu homeostazu medijatora porođaja, može
predstavljati faktor rizika za njegov nastanak. Parodontopatija je
hronično inflamatorno oboljenje prouzrokovano predominantno
anareobnim Gram negativnim bakterijama. Utvrđeno je da pacijenti
oboleli od parodontopatije imaju povišene nivoe IL-1β, IL-6, PGE2 i
TNF-α u gingivalnoj tečnosti u poređenju sa ispitanicima sa zdravim
parodontalnim tkivima. Takođe, usled povećane vaskularne
propustljivosti u uslovima inflamacije u parodoncijumu,
parodontopatogene bakterije i medijatori zapaljenja imaju
sposobnost da prodru u sistemsku cirkulaciju. Brojna istraživanja
su sprovedena sa ciljem da se istraži eventualna povezanost
inflamacije u parodoncijumu i prevremenog porođaja. Ustanovljeno je
da parodontopatija trudnica predstavlja visok faktor rizika za
nastanak prevremenog porođaja. Predložena su dva mehanizma na
osnovu kojih parodontopatija može uticati na prevremeni porođaj: 1)
direktni koji podrazumeva prodor parodontopatogenih bakterija u
feto-placentalnu jedinicu i sledstvenu stimulaciju lokalne
inflamacije ili 2) indirektni mehanizam prema kom medijatori
zapaljenja iz parodontalnog žarišta cirkulišu i sinergističkim
delovanjem povećaju lokalnu inflamaciju feto-placentalne jedinice.
U pogledu mogućeg indirektnog mehanizma povezanosti parodontopatije
i prevremenog porođaja, oskudni su podaci o uticaju inflamacije u
parodoncijumu na sistemske nivoe medijatora porođaja. Hipoteza ove
studije je da patogenetski mehanizmi parodontopatije i prevremenog
porođaja uključuju povećanu produkciju određenih istih
proinflamatornih medijatora, te je moguće postojanje udruženosti
ova dva patološka stanja...
Advisors/Committee Members: Čakić, Saša, 1958-.
Subjects/Keywords: periodontitis; preterm birth; interleukin-1beta;
interleukin-6; tumor necrosis factor-alpha; prostaglandin E2;
gingival crevicular fluid
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❌
APA ·
Chicago ·
MLA ·
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CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Perunović, Neda Đ., 1. (2016). Nivoi IL-1β , IL-6, TNF-α, PGE2 u gingivalnoj tečnosti i
u krvi prevremeno porođenih žena sa parodontitisom. (Thesis). Univerzitet u Beogradu. Retrieved from https://fedorabg.bg.ac.rs/fedora/get/o:10744/bdef:Content/get
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Perunović, Neda Đ., 1982-. “Nivoi IL-1β , IL-6, TNF-α, PGE2 u gingivalnoj tečnosti i
u krvi prevremeno porođenih žena sa parodontitisom.” 2016. Thesis, Univerzitet u Beogradu. Accessed April 15, 2021.
https://fedorabg.bg.ac.rs/fedora/get/o:10744/bdef:Content/get.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Perunović, Neda Đ., 1982-. “Nivoi IL-1β , IL-6, TNF-α, PGE2 u gingivalnoj tečnosti i
u krvi prevremeno porođenih žena sa parodontitisom.” 2016. Web. 15 Apr 2021.
Vancouver:
Perunović, Neda Đ. 1. Nivoi IL-1β , IL-6, TNF-α, PGE2 u gingivalnoj tečnosti i
u krvi prevremeno porođenih žena sa parodontitisom. [Internet] [Thesis]. Univerzitet u Beogradu; 2016. [cited 2021 Apr 15].
Available from: https://fedorabg.bg.ac.rs/fedora/get/o:10744/bdef:Content/get.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Perunović, Neda Đ. 1. Nivoi IL-1β , IL-6, TNF-α, PGE2 u gingivalnoj tečnosti i
u krvi prevremeno porođenih žena sa parodontitisom. [Thesis]. Univerzitet u Beogradu; 2016. Available from: https://fedorabg.bg.ac.rs/fedora/get/o:10744/bdef:Content/get
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
16.
Elizondo Ochoa, Jesús Eduardo.
Oral problems and Biopsychosocial factors associated with Human Immunodeficiency Virus infection.
Degree: Departament d'Odontologia, 2017, Universitat Internacional de Catalunya
URL: http://hdl.handle.net/10803/462917
► Antiretroviral therapy has transformed the disease caused by the human immunodeficiency virus (HIV) into a chronic condition. Molecular epidemiology and biopsychosocial unique approach systems are required to advance towards a better assessment and understanding of the complex interactions between HIV and its human host. Therefore, it was proposed to establish the biopsychosocial risk factors of oral pathologies in HIV, determining the relationship between oral‐systemic health status and antiretroviral treatment. Material and Methods Participants were recruited from HIV/AIDS healthcare providers, non‐governmental and community‐based organizations in Monterrey, México and adopted a non‐probability and snowball sampling. The research involved 202 …
(more)
▼ Antiretroviral therapy has transformed the disease caused by the human immunodeficiency virus (HIV) into
a chronic condition. Molecular epidemiology and biopsychosocial unique approach systems are required to
advance towards a better assessment and understanding of the complex interactions between HIV and its
human host. Therefore, it was proposed to establish the biopsychosocial risk factors of oral pathologies in
HIV, determining the relationship between oral‐systemic health status and antiretroviral treatment.
Material and Methods
Participants were recruited from HIV/AIDS healthcare providers, non‐governmental and community‐based
organizations in Monterrey, México and adopted a non‐probability and snowball sampling. The research
involved 202 consenting adult men who have sex with men (MSM [epidemiology], defined by the World
Health Organization as one of the Key populations at higher risk of acquiring HIV). Step 1 (Psychosocial
research). MSM filled out structured, analytical, self‐administered, anonymous questionnaires. Besides the
sociodemographic variables, the perception regarding public and private dental services and related
professionals there was also evaluated the perceived stigma associated with HIV/AIDS and sexual
orientation. Likewise, their perception towards rapid HIV‐1/2 testing in the dental practice. All the
biopsychosocial aspects were explored by designing psychometric Likert‐type scales. Step 2 (Biological
research). Gingival crevicular fluid (
GCF) and serum samples from 78 HIV‐positive adult male subjects (cases)
and 39 HIV‐negative male subjects (controls) were examined for 17 cytokines using multiplex ELISA.
Results
Psychosocial analyses revealed that most subjects reported omitting their HIV serodiagnosis and agreed that
dentists must be trained and qualified to treat patients with HIV/AIDS. The factorial analysis revealed two
elements in HIV/AIDS perception: experiences of stigma and discrimination in dental appointments and
feelings of concern regarding the attitudes of professionals or their teams concerning patients’ HIV
serodiagnosis. Most respondents expressed their willingness to take a rapid HIV‐1/2 screening test during
their dental visit. Nevertheless, most of them considered important that dental professionals must be well
trained before applying any rapid HIV‐1/2 tests. Factor analysis revealed two factors towards sexual
orientation: experiences of sexual orientation stigma and discrimination in dental settings, and feelings of
concern about the attitude of dentists and dental staff towards sexual orientation
Biomolecular analyses results of GCF concentrations of IL‐6, IL‐7, IL‐10, IL‐12, G‐CSF, and MCP‐1, as well as
serum concentrations of IL‐1β, IL‐2, and IL‐6, showed a statistically significant difference among subgroups.
We found a significant effect size correlation on …
Advisors/Committee Members: false (authoremailshow), Álvarez, Mario Moisés (director), Violant Holz, Deborah (codirector), Rivas Estilla, Ana María (codirector), false (authorsendemail).
Subjects/Keywords: HIV; AIDS ; Biomarkers; Cytokine; Gingival Crevicular Fluid; Periodontal Diseases; Antiretroviral Therapy; Public Health Dentistry; Social Discrimination; Psychometrics; México; Odontologia; 616.3
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APA ·
Chicago ·
MLA ·
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CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Elizondo Ochoa, J. E. (2017). Oral problems and Biopsychosocial factors associated with Human Immunodeficiency Virus infection. (Thesis). Universitat Internacional de Catalunya. Retrieved from http://hdl.handle.net/10803/462917
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Elizondo Ochoa, Jesús Eduardo. “Oral problems and Biopsychosocial factors associated with Human Immunodeficiency Virus infection.” 2017. Thesis, Universitat Internacional de Catalunya. Accessed April 15, 2021.
http://hdl.handle.net/10803/462917.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Elizondo Ochoa, Jesús Eduardo. “Oral problems and Biopsychosocial factors associated with Human Immunodeficiency Virus infection.” 2017. Web. 15 Apr 2021.
Vancouver:
Elizondo Ochoa JE. Oral problems and Biopsychosocial factors associated with Human Immunodeficiency Virus infection. [Internet] [Thesis]. Universitat Internacional de Catalunya; 2017. [cited 2021 Apr 15].
Available from: http://hdl.handle.net/10803/462917.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Elizondo Ochoa JE. Oral problems and Biopsychosocial factors associated with Human Immunodeficiency Virus infection. [Thesis]. Universitat Internacional de Catalunya; 2017. Available from: http://hdl.handle.net/10803/462917
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Freie Universität Berlin
17.
Pappe, Christina Laetitia.
Prolonged multimodal fasting modulates periodontal inflammation in patients with metabolic syndrome.
Degree: 2020, Freie Universität Berlin
URL: http://dx.doi.org/10.17169/refubium-27505
► Fasting exhibits anti-inflammatory effects in the human body. The impact on the periodontal tissues, however, has yet not been investigated. To examine the effects of…
(more)
▼ Fasting exhibits anti-inflammatory effects in the human body. The impact on the periodontal tissues, however, has yet not been investigated. To examine the effects of prolonged multimodal clinically controlled fasting on periodontal parameters, a non-interventional clinical trial was conducted in patients with metabolic syndrome (MetS).
All 47 in-patients diagnosed with MetS were enrolled between August and November 2016 after signing an informed consent. Each patient participated in a multimodal fasting program according to Buchinger with an energy intake of 1200 KJl/d. Outcomes were accessed at baseline (T1) and after fasting (T2), and the inflammatory status (c-reactive protein – CRP) and periodontal parameters (bleeding on probing – BOP,
gingival crevicular fluid rate – SFFR, Plaqueindex – PI) performed by two calibrated examiners, one single-blinded, using a pressure sensitive probe were documented. Furthermore, the metabolic parameters blood pressure (BD), waist circumference (TU), fasting glucose (NGLU), triglyceride (TRG), and HDL-level were assessed.
Summary statistics of baseline characteristics were separately calculated for both men and women using the Mann-Whitney-U test. Correlation analyses were performed using Spearmans rank correlation. Differences between T1 and T2 parameters were evaluated using the Wilcoxon test.
For the statistical analysis, data of 28 women were used. BOP and SFFR significantly decreased, while PI and CRP remained unchanged (BOP 39 % - 33,1 % (p<0,001), SFFR 73,9 PE - 59,3 PE (p<0,05), PI 69,2 % - 69,3 % (p=0,446), CRP 4,2 mg/l - 4,9 mg/l (p=0,178)). All metabolic parameters were significantly reduced after fasting (BD systolic 135 mmHg – 120 mmHg, diastolic 80 mmHg - 75 mmHg (<0,001), TU 111 cm - 107 cm (p<0,001), NGLU 99,1 mg/dl - 76,6 mg/dl (p<0,001), TRG 173,7 mg/dl - 135,2 mg/dl (p<0,001), HDL 50,3 mg/dl - 46,4 mg/dl (p=0,002)). The reduction in bleeding correlated with fasting glucose levels at baseline (r=0,37, p=0,049) as well as weight loss (r=0,4, p=0,04).
Prolonged fasting exhibits beneficial short-term effects on all MetS parameters and may facilitate the reduction of
gingival inflammation. CRP seems to be an inadequate marker to predict inflammatory processes in periodontal tissues while fasting. To evaluate the effect of fasting on periodontal disease further studies are required.
Advisors/Committee Members: female (gender), N.N. (firstReferee), N.N. (furtherReferee).
Subjects/Keywords: periodontal inflammation; fasting; bleeding on probing; metabolic syndrome; C-reactive protein; gingival crevicular fluid; ddc:610
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APA (6th Edition):
Pappe, C. L. (2020). Prolonged multimodal fasting modulates periodontal inflammation in patients with metabolic syndrome. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-27505
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Pappe, Christina Laetitia. “Prolonged multimodal fasting modulates periodontal inflammation in patients with metabolic syndrome.” 2020. Thesis, Freie Universität Berlin. Accessed April 15, 2021.
http://dx.doi.org/10.17169/refubium-27505.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Pappe, Christina Laetitia. “Prolonged multimodal fasting modulates periodontal inflammation in patients with metabolic syndrome.” 2020. Web. 15 Apr 2021.
Vancouver:
Pappe CL. Prolonged multimodal fasting modulates periodontal inflammation in patients with metabolic syndrome. [Internet] [Thesis]. Freie Universität Berlin; 2020. [cited 2021 Apr 15].
Available from: http://dx.doi.org/10.17169/refubium-27505.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Pappe CL. Prolonged multimodal fasting modulates periodontal inflammation in patients with metabolic syndrome. [Thesis]. Freie Universität Berlin; 2020. Available from: http://dx.doi.org/10.17169/refubium-27505
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
18.
Hart, Katherine Ann, D.D.S.
RANKL and Osteoprotegerin Levels in Response to Orthodontic Forces.
Degree: MDS, Orthodontics, 2012, University of Tennessee Health Science Center
URL: https://dc.uthsc.edu/dissertations/107
► Orthodontic tooth movement is mediated by interactions between PDL cells and those of the alveolus. One protein—the receptor activator nuclear factor kappa B ligand…
(more)
▼ Orthodontic tooth movement is mediated by interactions between PDL cells and those of the alveolus. One protein—the receptor activator nuclear factor kappa B ligand (RANKL)—is critical for osteoclastogenesis, and osteoprotegerin (OPG) is a decoy ligand that competitively inhibits RANKL. A higher RANKL/OPG ratio is associated with areas of bone resorption, while a lower ratio occurs in areas of bone deposition and homeostasis. There have been almost no clinical studies of RANKL and OPG expression in human subjects undergoing orthodontic tooth movement. The purpose of this study was to quantify changes in the levels of RANKL and of OPG expression in human
gingival crevicular fluid in growing (adolescent) and non-growing (adult) patients in response to orthodontic force. Untreated adolescents (under 18 years of age) and adults (over 18 years of age) had a calibrated force applied across a left-right pair of maxillary premolars with a transpalatal spring (TPS). RANKL and OPG were measured in
gingival crevicular fluid (
GCF) sampled serially from the pressure and tension sides of maxillary premolars at 5 different time points: before placement of transpalatal spring, 1 day (24 hours) after TPS placement, 2 days (48 hours) after TPS placement, 5 days (120 hours) after TPS placement (TPS was then removed), and 3 days (72 hours) after TPS removal. RANKL and OPG expression was measured by the ELISA assay. Expectations were that (1) force would raise RANKL and diminish OPG, (2) force removal would reverse the RANKL-OPG levels, (3) strength and duration of force are associated with RANKL-OPG levels, (4) responses would exhibit considerable inter-individual variation, (5) the RANKL/OPG levels will be higher in children due to general growth and bone remodeling in response to orthodontic forces, and (6) the RANKL/OPG levels will be lower in adults because no growth is occurring and osteoclastogenesis is triggered solely by orthodontic forces.
Gingival crevicular fluid (
GCF) volume increased significantly after applying force with the nickel-titanium coil spring. The volume remained elevated until the force was removed, and had not quite returned to baseline by 3 days (72 hours) following force removal. There were no significant differences found in the levels of
GCF collected in regards to age, sex, or race. When evaluating the changes in
gingival crevicular fluid in response to mechanical force, it appears that time is the significant factor regardless of the person’s age, sex, or race. In general, both RANKL and OPG levels decreased significantly over the time while the spring was in place; however, the RANKL/OPG ratio increased over time. No significant differences were found in the levels of RANKL when comparing sex, age, and race. Higher levels of OPG were found in males. A linear decrease in OPG was seen in regards to age; therefore, adults have less OPG than their younger counterparts. Although not significant, African American levels of OPG were higher than Caucasians. Further research is needed to better describe what…
Advisors/Committee Members: Edward F. Harris, Ph.D..
Subjects/Keywords: Gingival crevicular fluid; OPG; Orthodontic force; Osteoblasts; Osteoclasts; RANKL; Dentistry; Medicine and Health Sciences; Orthodontics and Orthodontology
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APA ·
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APA (6th Edition):
Hart, Katherine Ann, D. D. S. (2012). RANKL and Osteoprotegerin Levels in Response to Orthodontic Forces. (Thesis). University of Tennessee Health Science Center. Retrieved from https://dc.uthsc.edu/dissertations/107
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Hart, Katherine Ann, D D S. “RANKL and Osteoprotegerin Levels in Response to Orthodontic Forces.” 2012. Thesis, University of Tennessee Health Science Center. Accessed April 15, 2021.
https://dc.uthsc.edu/dissertations/107.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Hart, Katherine Ann, D D S. “RANKL and Osteoprotegerin Levels in Response to Orthodontic Forces.” 2012. Web. 15 Apr 2021.
Vancouver:
Hart, Katherine Ann DDS. RANKL and Osteoprotegerin Levels in Response to Orthodontic Forces. [Internet] [Thesis]. University of Tennessee Health Science Center; 2012. [cited 2021 Apr 15].
Available from: https://dc.uthsc.edu/dissertations/107.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Hart, Katherine Ann DDS. RANKL and Osteoprotegerin Levels in Response to Orthodontic Forces. [Thesis]. University of Tennessee Health Science Center; 2012. Available from: https://dc.uthsc.edu/dissertations/107
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
19.
Rogéria Pereira Gonçalves.
Efeito do tratamento periodontal não cirúrgico na atividade da peroxidase na saliva da glândula parótida e no fluído gengival.
Degree: 2012, University of São Paulo
URL: http://www.teses.usp.br/teses/disponiveis/23/23146/tde-15012013-165555/
► Dois importantes fatores inter-relacionados estão envolvidos na patogênese da doença periodontal: ativação do sistema imune e produção de peroxidases. Os objetivos deste estudo foram comparar…
(more)
▼ Dois importantes fatores inter-relacionados estão envolvidos na patogênese da doença periodontal: ativação do sistema imune e produção de peroxidases. Os objetivos deste estudo foram comparar os níveis da atividade do sistema peroxidase presentes no fluido gengival (MPO/FG) e saliva da parótida (POS) em pacientes portadores de periodontite crônica em relação a pacientes periodontalmente saudáveis e avaliar o efeito do tratamento periodontal não cirúrgico nestes indivíduos nestes parâmetros enzimáticos. MATERIAL E MÉTODO: Foram coletados dados dos parâmetros clínicos periodontais e amostras de FG e saliva da glândula parótida de 17 pacientes clinicamente saudáveis (GC) e de 17 pacientes portadores de periodontite crônica generalizada (GP) antes e depois do tratamento periodontal pareados em idade e sexo. As atividades de MPO/FG e POS Parótida foram avaliadas por espectofotometria. RESULTADOS: O GP apresentou valores maiores nos parâmetros clínicos
periodontais em relação ao GC, sendo que os mesmos foram reduzidos após tratamento periodontal. Além disso, o GP apresentou valores mais elevados de atividade de MPO no FG (p=0,04) do que o GC. Após tratamento periodontal os níveis de MPO/FG (p<0,001) e POS parótida (p=0,013) foram reduzidos significativamente. No GP houve correlação negativa e significativa entre POS da parótida e MPO no FG (r=-0,59, p=0,02). CONCLUSÕES: Na doença periodontal, as atividades de MPO no FG são maiores quando comparados ao grupo controle, e tanto de MPO/FG e POS parótida são reduzidas após tratamento periodontal.
Two important and interrelated factors are involved in the pathophysiology of periodontal diseases: the activation of immune system and the production of peroxidases. The objectives of this study were to examine the peroxidase activities present in Gingival Crevicular Fluid (MPO/GCF) and in Parotid Saliva (POS) in patients with generalized chronic periodontitis with healthy
controls and to compare the effects of periodontal therapy on enzyme activities. MATERIAL AND METHOD: Periodontal clinical measurements, parotid saliva and GCF samples were obtained of 17 age-matched healthy controls (PC) and 17 patients with chronic periodontal disease (PD) before treatment and after periodontal treatment. The MPO/GCF and POS parotid activities were determined spectrophotometrically. RESULTS: In PD group, clinical parameters, MPO/GCF (p=0,04) activities presented higher values than controls. After periodontal treatment levels of MPO/GCF (p<0.001) and POS parotid (p=0,013) were significantly reduced. In PD there was significant negative correlation between POS and MPO in the parotid FG (r =-0,59, p=0,02). CONCLUSIONS: In periodontal disease MPO/GCF presented higher levels than controls and MPO/GCF and POS parotid are reduced after treatment.
Advisors/Committee Members: Francisco Emilio Pustiglioni, Marcelo Nicolas Muscara, Silvana Regina Perez Orrico.
Subjects/Keywords: Fluido Gengival; Mieloperoxidase; Periodontite Crônica; Peroxidases; Saliva Parótida; Chronic Periodontal Diseases; Gingival Crevicular Fluid; Myeloperoxidase; Parotid Saliva; Peroxidase
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APA (6th Edition):
Gonçalves, R. P. (2012). Efeito do tratamento periodontal não cirúrgico na atividade da peroxidase na saliva da glândula parótida e no fluído gengival. (Masters Thesis). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/23/23146/tde-15012013-165555/
Chicago Manual of Style (16th Edition):
Gonçalves, Rogéria Pereira. “Efeito do tratamento periodontal não cirúrgico na atividade da peroxidase na saliva da glândula parótida e no fluído gengival.” 2012. Masters Thesis, University of São Paulo. Accessed April 15, 2021.
http://www.teses.usp.br/teses/disponiveis/23/23146/tde-15012013-165555/.
MLA Handbook (7th Edition):
Gonçalves, Rogéria Pereira. “Efeito do tratamento periodontal não cirúrgico na atividade da peroxidase na saliva da glândula parótida e no fluído gengival.” 2012. Web. 15 Apr 2021.
Vancouver:
Gonçalves RP. Efeito do tratamento periodontal não cirúrgico na atividade da peroxidase na saliva da glândula parótida e no fluído gengival. [Internet] [Masters thesis]. University of São Paulo; 2012. [cited 2021 Apr 15].
Available from: http://www.teses.usp.br/teses/disponiveis/23/23146/tde-15012013-165555/.
Council of Science Editors:
Gonçalves RP. Efeito do tratamento periodontal não cirúrgico na atividade da peroxidase na saliva da glândula parótida e no fluído gengival. [Masters Thesis]. University of São Paulo; 2012. Available from: http://www.teses.usp.br/teses/disponiveis/23/23146/tde-15012013-165555/
20.
Leticia Linares.
Análise comparativa da presença de mediadores inflamatórios no sulco gengival resultante das técnicas de moldagem em prótese fixa.
Degree: 2013, University of São Paulo
URL: http://www.teses.usp.br/teses/disponiveis/25/25146/tde-03092013-161416/
► A qualidade de uma reconstrução protética depende, primordialmente, de sua integração biológica e da sua adaptação. O afastamento gengival serve para se obter espaço para…
(more)
▼ A qualidade de uma reconstrução protética depende, primordialmente, de sua integração biológica e da sua adaptação. O afastamento gengival serve para se obter espaço para o material de moldagem e também para a visualização e acesso aos limites gengivais dos preparos, que são essenciais para a confecção de próteses com uma justeza de adaptação clínica. No entanto, a inserção de um material (fio retrator ou casquete) pode romper o sistema de fibras gengivais que conectam a margem gengival à superfície do cemento causando recessão gengival. Ocasionalmente, ocorre significativa inflamação ou perda de inserção. O objetivo deste trabalho foi quantificar a resposta inflamatória decorrente das diferentes técnicas de moldagem para prótese fixa, em termos da quantidade de IL-2, IL-4, IL-5, IL-10, TNF-α, IFN-γ, presentes no fluido gengival dos dentes com necessidade protética. A amostra foi composta por 10 dentes moldados pela técnica de
afastamento gengival com fio retrator e um grupo de 10 dentes moldados pela técnica do casquete. Os pacientes foram selecionados considerando-se a necessidade de prótese parcial fixa, higiene bucal satisfatória e não possuírem sinais clínicos de doença periodontal. Previamente à moldagem, uma tira de periopaper foi inserida no sulco gengival do paciente e foi mantida por 30 segundos. A coleta foi repetida 4 vezes para as faces mesiovestibular, distovestibular, mesiolingual e distolingual. Terminado o procedimento da moldagem, após 2 horas, 4 horas e 24 horas, respectivamente, foi repetido o procedimento de inserção do periopaper nos 4 sítios dos dentes. A amostra foi preparada para a citometria de fluxo (CBA - cytometric beads array). Os resultados foram analisados pelo teste de Tukey. Na análise de variância a 3 critérios, por meio da comparação entre técnica de moldagem, paciente e tempo para os valores de TNF-α, a relação tempo e paciente versus tempo foi
estatisticamente significante (p?0,05). Na comparação entre a técnica de moldagem com casquete e o fio retrator, não houve superioridade entre uma técnica e outra(p?0,05). O teste Tukey para a comparação intragrupo tempo (4 tempos), independente de técnica e paciente, mostrou relevância estatística entre os períodos antes da moldagem e após 24 horas (p=0,016) e, no período entre 2 horas e 24 horas após a moldagem (p=0,06). Portanto, foi possível concluir que não existe evidência científica que demonstre alguma superioridade das técnicas estudadas. Com isso, a escolha pelo método de afastamento gengival depende da situação clínica e habilidade do profissional.
The quality of a prosthetic reconstruction depends mostly on its integration and its biological adaptation. The gingival retraction serves to provide space for the impression material and also for visualize and give access to the gingival limit of tooth preparations, which are essential for making prostheses with a reliable
clinical precision fit. However, the inclusion of a material (retractor cord or acrilic resin coping) can break the system of…
Advisors/Committee Members: Paulo Martins Ferreira, Jose Henrique Rubo, Paulo Fukashi Yamaguti.
Subjects/Keywords: Citometria de fluxo; Líquido do sulco gengival; Técnicas de retração gengival; Crevicular fluid; Flow cytometry; Gingival retraction techniques
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APA ·
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APA (6th Edition):
Linares, L. (2013). Análise comparativa da presença de mediadores inflamatórios no sulco gengival resultante das técnicas de moldagem em prótese fixa. (Masters Thesis). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/25/25146/tde-03092013-161416/
Chicago Manual of Style (16th Edition):
Linares, Leticia. “Análise comparativa da presença de mediadores inflamatórios no sulco gengival resultante das técnicas de moldagem em prótese fixa.” 2013. Masters Thesis, University of São Paulo. Accessed April 15, 2021.
http://www.teses.usp.br/teses/disponiveis/25/25146/tde-03092013-161416/.
MLA Handbook (7th Edition):
Linares, Leticia. “Análise comparativa da presença de mediadores inflamatórios no sulco gengival resultante das técnicas de moldagem em prótese fixa.” 2013. Web. 15 Apr 2021.
Vancouver:
Linares L. Análise comparativa da presença de mediadores inflamatórios no sulco gengival resultante das técnicas de moldagem em prótese fixa. [Internet] [Masters thesis]. University of São Paulo; 2013. [cited 2021 Apr 15].
Available from: http://www.teses.usp.br/teses/disponiveis/25/25146/tde-03092013-161416/.
Council of Science Editors:
Linares L. Análise comparativa da presença de mediadores inflamatórios no sulco gengival resultante das técnicas de moldagem em prótese fixa. [Masters Thesis]. University of São Paulo; 2013. Available from: http://www.teses.usp.br/teses/disponiveis/25/25146/tde-03092013-161416/
21.
Paula Karine Jorge.
Proteomic analysis of crevicular fluid of traumatized primary teeth.
Degree: 2018, University of São Paulo
URL: http://www.teses.usp.br/teses/disponiveis/25/25145/tde-26082019-175820/
► Traumatic dental injuries (TDI) often happens in early childhood, the examination method is clinical and radiographic. Another methodology that has been used to aid in…
(more)
▼ Traumatic dental injuries (TDI) often happens in early childhood, the examination method is clinical and radiographic. Another methodology that has been used to aid in TDI diagnosis is molecular biology. A fluid that has been studied in molecular biology is gingival crevicular fluid (GCF), which is an appropriate fluid to evaluate the relation between periodontal tissues and pulp, and its compounds will depend on either the health or inflammation level of tissues. Therefore, this study aimed to characterize the proteins/peptides in GCF of primary tooth with different sequelae of TDI to clarify the proteins/peptides functions in order to contribute in the diagnosis of pulp and periodontal conditions. The sample was composed for 8 children with TDI, ranging 4 to 6 years. GCF samples were collected in 4 points of the gingival sulcus of both the 12 traumatized teeth and the 8 primary first molar, divided into 5 groups: Molar group (deciduous first
molar), No alteration, Pulp Canal Obliteration (PCO), Repair-Related Resorption (RRR) and Pulp Necrosis (PN). GCF proteins were subjected to liquid chromatography electrospray ionization mass spectrometry for identification and characterization. 436 single proteins/peptides were found in this study. 43 (9.86%) were in No alteration group, 92 (21.10%) in PCO group, 23 (5.28%) in RRR group, 16 (3.67%) in PN group, and finaly, 114 (26.15%) in molar group. All groups revealed the following peptides/proteins functions: immune response, cell degradation and recycling, repair and maintenance, enzymatic process, cell binding, cell signaling, cell differentiation, cell migration, structural components and antioxidant activity. Proteins functions related to the specific groups: molar group played role in homeostasis process. No alteration group, I6L9F6_HUMAN, NEB2_HUMAN, Q5T0H8_HUMAN, H0YJG4_HUMAN are related to nervous tissue, and, TET1_HUMAN to odontoblast differentiation. RRR group,
CALX_HUMAN, B8ZZF0_HUMAN are related to senescence, and KMT2D_HUMAN mutation is associated to skeletal deformation. PCO group, CATA_HUMAN is response to hypoxia, fibroblast transformation, and osteoblast differentiation; MTA70_HUMAN is related to stem cell differentiation; ITPR2_HUMAN releases calcium ion into cytosol. Fistula group: Q8TAS6_HUMAN development of neuronal tissue; E9PDR3_HUMAN neurotransmitter release, cell division and death; B4DT36_HUMAN play a role in conducting axon; C9JN07_HUMAN mitotic process; RSF1_HUMAN DNA repair; Q19KS2_HUMAN immune defense. Concluding, TDI of primary tooth profile undergoing different sequelae type was characterized. The proteins of molar group exhibited complete homeostasis. In no alteration group, the proteins play a role in maintaining the nervous tissue. The proteins of PCO group were involved in cell transformation and differentiation to reach canal root obliteration. The proteins of RRR group revealed a senescence process. In fistula
group the proteins play a role to surround the inflammation site.
O trauma dentário (TD) geralmente ocorre na…
Advisors/Committee Members: Maria Aparecida de Andrade Moreira Machado, Elaine Marcilio Santos, Walter Luiz Siqueira Junior, Thais Marchini de Oliveira Valarelli.
Subjects/Keywords: Dente decíduo; Líquido do sulco gengival; Proteoma; Traumatismos dentários; Gingival crevicular fluid; Proteome; Tooth injuries; Tooth,; deciduous
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APA ·
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MLA ·
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APA (6th Edition):
Jorge, P. K. (2018). Proteomic analysis of crevicular fluid of traumatized primary teeth. (Doctoral Dissertation). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/25/25145/tde-26082019-175820/
Chicago Manual of Style (16th Edition):
Jorge, Paula Karine. “Proteomic analysis of crevicular fluid of traumatized primary teeth.” 2018. Doctoral Dissertation, University of São Paulo. Accessed April 15, 2021.
http://www.teses.usp.br/teses/disponiveis/25/25145/tde-26082019-175820/.
MLA Handbook (7th Edition):
Jorge, Paula Karine. “Proteomic analysis of crevicular fluid of traumatized primary teeth.” 2018. Web. 15 Apr 2021.
Vancouver:
Jorge PK. Proteomic analysis of crevicular fluid of traumatized primary teeth. [Internet] [Doctoral dissertation]. University of São Paulo; 2018. [cited 2021 Apr 15].
Available from: http://www.teses.usp.br/teses/disponiveis/25/25145/tde-26082019-175820/.
Council of Science Editors:
Jorge PK. Proteomic analysis of crevicular fluid of traumatized primary teeth. [Doctoral Dissertation]. University of São Paulo; 2018. Available from: http://www.teses.usp.br/teses/disponiveis/25/25145/tde-26082019-175820/
22.
Fiorini, Tiago.
Níveis sistêmicos e periodontais de citocinas durante a gestação : correlações e efeito da terapia periodontal.
Degree: 2012, Brazil
URL: http://hdl.handle.net/10183/142563
► A doença periodontal tem sido frequentemente associada ao parto pretermo. A plausibilidade biológica para tal associação baseia-se na hipótese de uma inflamação sistêmica de baixa…
(more)
▼ A doença periodontal tem sido frequentemente associada ao parto pretermo. A plausibilidade biológica para tal associação baseia-se na hipótese de uma inflamação sistêmica de baixa intensidade de origem periodontal. Entretanto, os estudos de intervenção que investigaram o efeito da terapia periodontal durante a gestação não observaram reduções significativas na incidência de prematuridade. Como diversas citocinas têm sido associadas tanto a doença periodontal quanto ao parto pretermo, cogita-se que elas desempenhem um papel importante na associação observada. Até o presente momento, pouco se sabe a respeito da correlação entre os níveis de citocinas no soro e no fluído
crevicular gengival (FCG), assim como do efeito da terapia periodontal sobre esses marcadores de inflamação em gestantes. O objetivo desta tese foi avaliar a relação entre níveis sistêmicos e periodontais de biomarcadores inflamatórios relacionados com a resposta imune periodontal e
também com os mecanismos de parto. Também investigou-se o efeito da terapia periodontal sobre os níveis dessas citocinas durante a gestação e 30 dias após o parto. Esta tese é composta por dois estudos que utilizaram uma sub-amostra de mulheres que haviam sido recrutadas para um ensaio clínico randomizado maior que investigou o efeito da terapia periodontal sobre a incidência de prematuridade. Mulheres entre 18-35 anos e com até 20 semanas de gestação foram aleatoriamente alocadas para receber tratamento periodontal não cirúrgico completo até a 24a semana de gestação (grupo teste) ou apenas uma consulta de uma remoção de cálculo supragingival (grupo controle). Dados clínicos e amostras de sangue e FCG foram coletadas no início do estudo, entre 26-28 semanas de gestação e 30 dias após o parto. Quatro sítios periodontais por paciente foram aleatoriamente selecionados para coleta de FCG entre aqueles com maior profundidade de sondagem. Os níveis de IL-1β, IL-6, IL-8, IL-10, IL- 12p70 e
FNT-α foram analisados por citometria de fluxo. No estudo 1, investigou-se a correlação e concordância entre os níveis periodontais e sistêmicos dessas citocinas em 100 pacientes, utilizando dados coletados até a 20a semana de gestação. As pacientes apresentaram extensa inflamação e limitada destruição periodontal. A correlação entre os níveis de citocinas no soro e no FCG foi baixa e não significativa, com exceção da IL-12p70 que mostrou uma correlação moderada, porém significativa, entre as duas fontes (r=0.32, p=0.001). Os níveis de citocinas observados no FCG explicaram menos de 10% dos respectivos níveis observados no soro, com exceção da IL-12p70 em que eles foram responsáveis por 23% dos níveis séricos (p=0.0001, r2=0.23). A profundidade de sondagem e o sangramento a sondagem estiveram significativamente associados com os níveis de IL-1β, IL-6 e IL-8 no FCG, mas tiveram efeitos limitados sobre os níveis sistêmicos de todas as citocinas. No estudo 2, comparou-se o efeito da
terapia periodontal durante a gestação (n=30) com uma consulta única de remoção de cálculo supragingival (n=30) sobre…
Advisors/Committee Members: Oppermann, Rui Vicente, Susin, Cristiano.
Subjects/Keywords: Odontologia : Na gravidez; Periodontia : Doencas : Tratamento; periodontal therapy; Periodontal disease; Pregnancy; Interleukins; Low-grade systemic inflammation; Gingival crevicular fluid
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APA (6th Edition):
Fiorini, T. (2012). Níveis sistêmicos e periodontais de citocinas durante a gestação : correlações e efeito da terapia periodontal. (Doctoral Dissertation). Brazil. Retrieved from http://hdl.handle.net/10183/142563
Chicago Manual of Style (16th Edition):
Fiorini, Tiago. “Níveis sistêmicos e periodontais de citocinas durante a gestação : correlações e efeito da terapia periodontal.” 2012. Doctoral Dissertation, Brazil. Accessed April 15, 2021.
http://hdl.handle.net/10183/142563.
MLA Handbook (7th Edition):
Fiorini, Tiago. “Níveis sistêmicos e periodontais de citocinas durante a gestação : correlações e efeito da terapia periodontal.” 2012. Web. 15 Apr 2021.
Vancouver:
Fiorini T. Níveis sistêmicos e periodontais de citocinas durante a gestação : correlações e efeito da terapia periodontal. [Internet] [Doctoral dissertation]. Brazil; 2012. [cited 2021 Apr 15].
Available from: http://hdl.handle.net/10183/142563.
Council of Science Editors:
Fiorini T. Níveis sistêmicos e periodontais de citocinas durante a gestação : correlações e efeito da terapia periodontal. [Doctoral Dissertation]. Brazil; 2012. Available from: http://hdl.handle.net/10183/142563
23.
Teixeira, Nancielli.
Influência de diferentes resinas compostas e técnicas de polimento sobre os tecidos periodontais próximos a lesões cervicais não cariosas avaliação clínica randomizada.
Degree: 2015, Universidade Estadual do Oeste do Parana; Programa de Pós-Graduação Stricto Sensu em Odontologia Nível de Mestrado; UNIOESTE; BR; Odontologia
URL: http://tede.unioeste.br:8080/tede/handle/tede/734
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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
The aim of this study was to evaluate the influence of different composite resins and technical polishing and finishing over periodontals tissues and gingival crevicular fluid in cervical lesions restorations noncarious (LCNC). Initially were evaluated 272 teeths of patients with complaints related to LCNC and, acordding to the inclusion and exclusion criteria were selected 60 teeths for elegibility. Each tooth received a restoration with a kind of composite resin (Resin Tetric N-Ceram® or Resin Z350 XT®) in both quadrants, varying the polishing technique ( Astropol® Polishing rubber or Sof-lex® Disks). Periodontal tissues analysis, the
longitudinal evaluation of restaurations and the gengival crevicular fluid collect were taken prior to scalling and root planning and also at 30, 60, 120 and 180 days of restaurations making. After the data collection and tabulation , these were submited to the Friedman test, with a significance level of 5%. The results revealed that resins and polishing techniques applied in this study showed no estatistical differences at the end of follow-up in any of the analyzes. However all groups evaluated showed differences between the initial and final times (p <0.05). From the results obtained it was concluded that regardless of the restorative material or polishing technique, the restoration of LCNC cavities improved the periodontal health of patients
O objetivo desse trabalho foi avaliar a influência de diferentes resinas compostas e técnicas de acabamento e polimento sobre os tecidos periodontais e o fluído crevicular gengival em restaurações de lesões cervicais não cariosas.
Foram avaliados inicialmente 272 dentes de pacientes com queixas relacionadas à LCNC e, a partir dos critérios de inclusão e exclusão definidos, foram selecionados para elegibilidade 60 dentes, divididos em 4 grupos com N:15 dentes. Cada dente recebeu restauração com um tipo de resina composta nanoparticulada (Resina Tetric N-Ceram® ou Resina Z350 XT®) nos dois hemiarcos, variando a técnica de polimento (Borrachas de polimento Astropol® ou Discos Sof-lex®). A análise periodontal dos tecidos, a avaliação longitudinal das restaurações e a coleta do fluido crevicular gengival foram realizadas antes da raspagem e alisamento corono-radicular, e também aos 30, 60, 120 e 180 dias após a confecção das restaurações. Após a obtenção e tabulação dos dados, esses foram submetidos ao teste de Friedman, com nível de significância de 5%. Os resultados revelaram que as resinas e as técnicas de polimento utilizadas neste estudo não apresentaram diferenças estatísticas ao final do período de
acompanhamento em nenhuma das análises. Porém, todos os grupos avaliados apresentaram diferenças entre os tempos iniciais e finais (p<0,05).…
Advisors/Committee Members: Mendonça, Marcio José, Busato, Priscilla do Monte Ribeiro, Carrilho Neto, Antonio.
Subjects/Keywords: Fluido crevicular gengival; inflamação; restauração; resina composta; polimento dentário; Gingival crevicular fluid; Inflammation; Restoration; Composite resin; Dental polishing; CNPQ::CIENCIAS DA SAUDE::ODONTOLOGIA
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APA (6th Edition):
Teixeira, N. (2015). Influência de diferentes resinas compostas e técnicas de polimento sobre os tecidos periodontais próximos a lesões cervicais não cariosas avaliação clínica randomizada. (Masters Thesis). Universidade Estadual do Oeste do Parana; Programa de Pós-Graduação Stricto Sensu em Odontologia Nível de Mestrado; UNIOESTE; BR; Odontologia. Retrieved from http://tede.unioeste.br:8080/tede/handle/tede/734
Chicago Manual of Style (16th Edition):
Teixeira, Nancielli. “Influência de diferentes resinas compostas e técnicas de polimento sobre os tecidos periodontais próximos a lesões cervicais não cariosas avaliação clínica randomizada.” 2015. Masters Thesis, Universidade Estadual do Oeste do Parana; Programa de Pós-Graduação Stricto Sensu em Odontologia Nível de Mestrado; UNIOESTE; BR; Odontologia. Accessed April 15, 2021.
http://tede.unioeste.br:8080/tede/handle/tede/734.
MLA Handbook (7th Edition):
Teixeira, Nancielli. “Influência de diferentes resinas compostas e técnicas de polimento sobre os tecidos periodontais próximos a lesões cervicais não cariosas avaliação clínica randomizada.” 2015. Web. 15 Apr 2021.
Vancouver:
Teixeira N. Influência de diferentes resinas compostas e técnicas de polimento sobre os tecidos periodontais próximos a lesões cervicais não cariosas avaliação clínica randomizada. [Internet] [Masters thesis]. Universidade Estadual do Oeste do Parana; Programa de Pós-Graduação Stricto Sensu em Odontologia Nível de Mestrado; UNIOESTE; BR; Odontologia; 2015. [cited 2021 Apr 15].
Available from: http://tede.unioeste.br:8080/tede/handle/tede/734.
Council of Science Editors:
Teixeira N. Influência de diferentes resinas compostas e técnicas de polimento sobre os tecidos periodontais próximos a lesões cervicais não cariosas avaliação clínica randomizada. [Masters Thesis]. Universidade Estadual do Oeste do Parana; Programa de Pós-Graduação Stricto Sensu em Odontologia Nível de Mestrado; UNIOESTE; BR; Odontologia; 2015. Available from: http://tede.unioeste.br:8080/tede/handle/tede/734
24.
Bernardon, Paula.
Efeito do tratamento periodontal em pacientes com Diabetes Mellitus Tipo 2 moderadamente compensados e descompensados.
Degree: 2015, Universidade Estadual do Oeste do Parana; Programa de Pós-Graduação Stricto Sensu em Odontologia Nível de Mestrado; UNIOESTE; BR; Odontologia
URL: http://tede.unioeste.br:8080/tede/handle/tede/736
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Fundação Araucária
Aim: Recent studies demonstrate Diabetes Mellitus (DM) as a risk factor for the impairment of periodontal health and a growing body of evidence has been supporting periodontal disease (PD) as having an adverse effect on glycemic control and on the pathophysiology of the diabetes-related complications. This study aims to evaluate the effect of periodontal therapy immoderately compensated and decompensated type 2 diabetic patients. Subjects and methods: 40 patients with DM2 and periodontal disease were selected and divided into two groups: Group 1: Moderately compensated; Group 2: Decompensated. Of these 40 patients, only 35 participated in the study. The analyses were performed at 0, 3 and 6 months
after scaling and root planning and including clinical periodontal parameters and the quantification of gingival crevicular fluid (GCF). Glycated hemoglobin (HbA1c), fasting glucose (FG) and IL1-β expression were measured. Results: Both groups presented improvement in all clinical periodontal parameters as well as quantification of gingival crevicular fluid and in the expression of IL-1ß present in the fluid after 6 months. However, no statistically significant difference was found in the levels of HbA1C in the first group after 6 months, although a significant increase was found after six months in the other group. While in relation to the FG, a great improvement was found in the first group and a significant increase in the second group after six months. Conclusion: It was possible to observe that conventional periodontal treatment (scaling and root planing) is more effective for moderately compensated type 2 diabetic patients glycemic control rather than for the
decompensated patients.
Estudos recentes demonstraram o Diabetes Mellitus (DM) como um fator de risco para o comprometimento da saúde periodontal e crescentes evidências apontam que a doença periodontal (DP) tem um efeito adverso sobre o controle glicêmico e uma participação ativa na fisiopatologia das complicações relacionadas ao DM. Objetivo: Avaliar o efeito do tratamento periodontal em pacientes portadores de Diabetes Mellitus tipo 2 moderadamente compensados e descompensados. Metodologia: Foram selecionados 40 pacientes com DM2 e periodontite, estes foram divididos em dois grupos: Grupo 1: moderadamente compensados; Grupo 2: descompensados. Destes 40 pacientes, apenas 35 participaram do estudo. As análises foram realizadas aos 0, 3 e 6 meses após raspagem e alisamento radicular, incluindo parâmetros clínicos periodontais e a quantidade de fluido crevicular gengival (GCF). Foram dosadas a hemoglobina glicada (HbA1c), a glicemia em jejum (GJ) e a expressão IL1β.
Resultados: Houve uma melhora de todos os parâmetros clínicos periodontais avaliados em ambos os grupos, assim como da quantidade de GFC…
Advisors/Committee Members: Nassar, Patricia Oehlmeyer, Camilott, Veridiana, Suedam, Ivy Kiemle Trindade.
Subjects/Keywords: Diabetes Mellitus; Fluido crevicular gengival; Doença periodontal; Controle glicêmico; Diabetes Mellitus; Gingival crevicular fluid; Periodontal disease; Glycemic control; CNPQ::CIENCIAS DA SAUDE::ODONTOLOGIA
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APA (6th Edition):
Bernardon, P. (2015). Efeito do tratamento periodontal em pacientes com Diabetes Mellitus Tipo 2 moderadamente compensados e descompensados. (Masters Thesis). Universidade Estadual do Oeste do Parana; Programa de Pós-Graduação Stricto Sensu em Odontologia Nível de Mestrado; UNIOESTE; BR; Odontologia. Retrieved from http://tede.unioeste.br:8080/tede/handle/tede/736
Chicago Manual of Style (16th Edition):
Bernardon, Paula. “Efeito do tratamento periodontal em pacientes com Diabetes Mellitus Tipo 2 moderadamente compensados e descompensados.” 2015. Masters Thesis, Universidade Estadual do Oeste do Parana; Programa de Pós-Graduação Stricto Sensu em Odontologia Nível de Mestrado; UNIOESTE; BR; Odontologia. Accessed April 15, 2021.
http://tede.unioeste.br:8080/tede/handle/tede/736.
MLA Handbook (7th Edition):
Bernardon, Paula. “Efeito do tratamento periodontal em pacientes com Diabetes Mellitus Tipo 2 moderadamente compensados e descompensados.” 2015. Web. 15 Apr 2021.
Vancouver:
Bernardon P. Efeito do tratamento periodontal em pacientes com Diabetes Mellitus Tipo 2 moderadamente compensados e descompensados. [Internet] [Masters thesis]. Universidade Estadual do Oeste do Parana; Programa de Pós-Graduação Stricto Sensu em Odontologia Nível de Mestrado; UNIOESTE; BR; Odontologia; 2015. [cited 2021 Apr 15].
Available from: http://tede.unioeste.br:8080/tede/handle/tede/736.
Council of Science Editors:
Bernardon P. Efeito do tratamento periodontal em pacientes com Diabetes Mellitus Tipo 2 moderadamente compensados e descompensados. [Masters Thesis]. Universidade Estadual do Oeste do Parana; Programa de Pós-Graduação Stricto Sensu em Odontologia Nível de Mestrado; UNIOESTE; BR; Odontologia; 2015. Available from: http://tede.unioeste.br:8080/tede/handle/tede/736
25.
Kelly Rocio Vargas Villafuerte.
Efeitos do tratamento periodontal não-cirúrgico sobre o perfil de citocinas inflamatórias em pacientes com periodontite crônica e câncer de mama submetidos à quimioterapia.
Degree: 2017, University of São Paulo
URL: http://www.teses.usp.br/teses/disponiveis/58/58132/tde-23022018-151200/
► Pacientes com câncer de mama sob quimioterapia tem níveis aumentados de marcadores inflamatórios, que podem piorar condições periodontais pré-existentes. Este estudo avaliou o efeito do…
(more)
▼ Pacientes com câncer de mama sob quimioterapia tem níveis aumentados de marcadores inflamatórios, que podem piorar condições periodontais pré-existentes. Este estudo avaliou o efeito do tratamento periodontal nao cirúrgico (TPNC) e estabeleceu a correlação entre os parâmetros clínicos com os níveis de citocinas presentes no fluido
crevicular gengival (FCG) antes e após TPNC. Quarenta indivíduos foram alocados em dois grupos; pacientes com periodontite cronica (PC) (n=20) e pacientes com câncer de mama com periodontite crônica (CAN/PC) (n=20). Os seguintes parâmetros clínicos e imunológicos foram analisados: i) profundidade de sondagem (PS), nível clinico de inserção (NCI), índice gengival (IG), índice de placa (IP), ii) avaliação dos níveis de Interleucina (IL) - 4, IL-10, IL-17, IL-2, IL-6, IL-1β, Interferon gama (INF-γ), Fator de Necrose Tumoral alfa (TNF-α) e Fator de Crescimento Tumoral-beta (TGF-β) no
fluido
crevicular gengival (Luminex), no baseline, 45 dias e 180 dias após TPNC. Os dados obtidos foram estatisticamente analisados. Nas comparações entre grupos: No baseline, o grupo PC apresentou níveis maiores de INF-γ e níveis menores de IL- 10 e TGF-β quando comparados ao grupo CAN/PC. Aos 45 dias o grupo CAN/PC apresentou níveis mais reduzidos de TNF-α (p < 0,0001) em comparação com o grupo PC. Em relação aos 180 dias, o grupo PC apresentou níveis mais reduzidos de INF-γ (p < 0,001), IL-2 (p < 0. 001), TNF-α (p < 0,0001) e níveis elevados de IL-10 (p < 0,01) e TGF-β (p < 0,001), quando comparados ao grupo CAN/PC. Nas comparações entre períodos de tempo: o grupo CAN/PC apresentou uma redução significativa de IL-2 aos 45 e 180 dias (p < 0,05) em comparação com baseline, TNF-α teve uma redução aos 45 dias, em comparação com baseline (p < 0.0001), alem
disso, houve uma redução significativa do TGF-β aos 180 dias em comparação com baseline (p < 0,0001). Enquanto IL-1β, foi aumentado aos 45 dias em comparação com baseline (p < 0,05). No grupo PC, houve uma redução significativa dos níveis de INF-&gama; aos 180 dias, em comparação com baseline (p < 0,0001) e 45 dias (p < 0,05). Da mesma forma, IL-2 e TNF-α reduziram aos 180 dias, em comparação com baseline (p < 0,0001) e 45 dias (p < 0,0001), bem como um aumento de TGF-β aos 180 dias, em comparação com baseline (p < 0,05) e 45 dias (p < 0,0001). Na análise de correlação entre os parâmetros clínicos e os níveis de citocinas do FCG: No grupo CAN/PC, foi encontrado uma positiva correlação entre PS e os níveis de TNF-α (r = 0.6489, p = 0.002) no baseline. IL-17 foi positivamente correlacionado com redução de PS (r = 0.4596, p = 0.04) aos 180 dias; assim também IL-6 foi
positivamente correlacionado com redução de PS e ganho de NCI (r = 0.4513, p = 0.05, r = 0.5578, p = 0.01, respectivamente) aos 180 dias. No grupo PC, IL-17 foi positivamente correlacionada com PS e NCI (r = 0.4558, p = 0.04, r= 0.5447, p = 0.01, respectivamente) no baseline. IL-1β foi positivamente…
Advisors/Committee Members: Daniela Bazan Palioto Bulle, Renato Corrêa Viana Casarin, Francisco José Cândido dos Reis, Morgana Rodrigues Guimaraes Stabili.
Subjects/Keywords: Câncer de mama; Citocinas; Fluido crevicular gengival; Periodontite crônica; Quimioterapia; Terapia periodontal não cirúrgica; Breast cancer; Chemotherapy; Chronic periodontitis; Cytokines; Gingival crevicular fluid; Non-surgical periodontal therapy
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APA ·
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APA (6th Edition):
Villafuerte, K. R. V. (2017). Efeitos do tratamento periodontal não-cirúrgico sobre o perfil de citocinas inflamatórias em pacientes com periodontite crônica e câncer de mama submetidos à quimioterapia. (Doctoral Dissertation). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/58/58132/tde-23022018-151200/
Chicago Manual of Style (16th Edition):
Villafuerte, Kelly Rocio Vargas. “Efeitos do tratamento periodontal não-cirúrgico sobre o perfil de citocinas inflamatórias em pacientes com periodontite crônica e câncer de mama submetidos à quimioterapia.” 2017. Doctoral Dissertation, University of São Paulo. Accessed April 15, 2021.
http://www.teses.usp.br/teses/disponiveis/58/58132/tde-23022018-151200/.
MLA Handbook (7th Edition):
Villafuerte, Kelly Rocio Vargas. “Efeitos do tratamento periodontal não-cirúrgico sobre o perfil de citocinas inflamatórias em pacientes com periodontite crônica e câncer de mama submetidos à quimioterapia.” 2017. Web. 15 Apr 2021.
Vancouver:
Villafuerte KRV. Efeitos do tratamento periodontal não-cirúrgico sobre o perfil de citocinas inflamatórias em pacientes com periodontite crônica e câncer de mama submetidos à quimioterapia. [Internet] [Doctoral dissertation]. University of São Paulo; 2017. [cited 2021 Apr 15].
Available from: http://www.teses.usp.br/teses/disponiveis/58/58132/tde-23022018-151200/.
Council of Science Editors:
Villafuerte KRV. Efeitos do tratamento periodontal não-cirúrgico sobre o perfil de citocinas inflamatórias em pacientes com periodontite crônica e câncer de mama submetidos à quimioterapia. [Doctoral Dissertation]. University of São Paulo; 2017. Available from: http://www.teses.usp.br/teses/disponiveis/58/58132/tde-23022018-151200/
26.
Átila Vinicius Vitor Nobre.
Impacto do tratamento periodontal não-cirurgico no perfil clínico e imunológico e na colonização oral por Candida spp em indivíduos infectados pelo HIV com periodontite crônica.
Degree: 2018, University of São Paulo
URL: http://www.teses.usp.br/teses/disponiveis/58/58132/tde-29082018-130247/
► A introdução da terapia antirretroviral (TARV) causou impacto significativo na qualidade de vida e controle de infecções oportunistas em indivíduos infectados pelo vírus da imunodeficiência…
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▼ A introdução da terapia antirretroviral (TARV) causou impacto significativo na qualidade de vida e controle de infecções oportunistas em indivíduos infectados pelo vírus da imunodeficiência humana (HIV), desta forma é crescente o interesse no estudo de doenças orais crônicas na era pós-TARV, com destaque para a periodontite crônica (PC). Foi avaliado o efeito da terapia periodontal não-cirúrgica (TPNC) nos parâmetros clínicos periodontais, perfil de citocinas salivares e no fluido
crevicular gengival (FCG) e na colonização oral por Candida spp em indivíduos infectados pelo HIV com PC, por meio de um estudo quase-experimental. Indivíduos infectados pelo HIV (grupo teste) e não-infectados pelo HIV (grupo controle), ambos com PC foram avaliados. Os seguintes parâmetros foram analisados (1) clínicos, (2), imunológicos e (3) e microbiológicos: 1) índice gengival (IG), profundidade de sondagem (PS), nível de inserção clínica (NIC) e número de dentes; 2)
níveis de linfócitos T CD4+ e carga viral plasmática (apenas para o grupo teste), níveis salivares de interleucina (IL)-6, IL-8 e fator de necrose tumoral-alfa (TNF-α) e níveis no FCG de lactoferrina (Lf) e histatina-5 (Hst-5), e 3) colonização oral por Candida spp. Os parâmetros foram analisados em três diferentes tempos (tempo 0 = baseline; tempo 2 = 30 dias após TPNC e tempo 3 = 90 dias após TPNC). A contagem de linfócitos T CD4+ e carga viral foi realizada em amostras de sangue dos pacientes do grupo teste, as ILs, Lf e Hst-5 foram dosadas por Enzyme-Lynked Immunosorbent Assay (ELISA) e a contagem e classificação de Candida spp foram determinadas a partir de amostras de enxaguado bucal. Nas comparações entre grupos por tempo, ambos apresentaram redução de IG (p<0,0001), PS (p<0,0001), bem como ganho de inserção clínica (p<0,0001) e houve aumento na contagem de linfócitos T CD4+ (p=0,0120) para o grupo teste. A quantificação da carga viral variou
(p=0,2984), embora tenha ocorrido diminuição de alguns outliers iniciais com valores altos. Em relação aos biomarcadores, não foi possível observar diminuição estatisticamente significante com o tempo para IL-6 (p=0,6879), IL-8 (p=0,0557), TNF-α(p=0,7013), Lf (p=0,8188) e Hst-5 (p=0,1780) embora o declínio para IL-8 tenha sido mais acentuado. Pôde-se observar uma tendência de aumento entre o tempo 0 e tempo 2, seguido de 20 diminuição no tempo 3 para os grupos teste e controle da IL-8 e Hst-5, em contraste com o declínio linear para o grupo controle da IL-6. As concentrações de Lf apresentaram padrão de aumento do tempo 0 ao tempo 2 e diminuição do tempo 2 ao tempo 3 para o grupo teste, ao contrário do grupo controle, que diminuiu do tempo 0 ao tempo 2 e diminuiu do tempo 2 ao tempo 3. A análise de Candida spp foi dicotomizada entre os grupos teste e controle e mostrou diminuição significante ao longo dos tempos para ambos os grupos (p<0,0001). Pode-se concluir que
a TPNC teve impacto benéfico nos marcadores sistêmicos da infecção pelo HIV e nos níveis de IL-8 salivar, além de reduzir a colonização oral por Candida…
Advisors/Committee Members: Ana Carolina Fragoso Motta, Karen Mirna Loro Morejon, Mario Taba Junior, Camila Tirapelli.
Subjects/Keywords: Candida spp; Células inflamatórias; Citocinas inflamatórias; Fluido crevicular gengival; HIV; Periodontite crônica; Tratamento periodontal; Candida spp; Chronic periodontitis; Gingival crevicular fluid; HIV; Inflammatory cells; Inflammatory cytokines; Periodontal therapy
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APA (6th Edition):
Nobre, . V. V. (2018). Impacto do tratamento periodontal não-cirurgico no perfil clínico e imunológico e na colonização oral por Candida spp em indivíduos infectados pelo HIV com periodontite crônica. (Masters Thesis). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/58/58132/tde-29082018-130247/
Chicago Manual of Style (16th Edition):
Nobre, Átila Vinicius Vitor. “Impacto do tratamento periodontal não-cirurgico no perfil clínico e imunológico e na colonização oral por Candida spp em indivíduos infectados pelo HIV com periodontite crônica.” 2018. Masters Thesis, University of São Paulo. Accessed April 15, 2021.
http://www.teses.usp.br/teses/disponiveis/58/58132/tde-29082018-130247/.
MLA Handbook (7th Edition):
Nobre, Átila Vinicius Vitor. “Impacto do tratamento periodontal não-cirurgico no perfil clínico e imunológico e na colonização oral por Candida spp em indivíduos infectados pelo HIV com periodontite crônica.” 2018. Web. 15 Apr 2021.
Vancouver:
Nobre VV. Impacto do tratamento periodontal não-cirurgico no perfil clínico e imunológico e na colonização oral por Candida spp em indivíduos infectados pelo HIV com periodontite crônica. [Internet] [Masters thesis]. University of São Paulo; 2018. [cited 2021 Apr 15].
Available from: http://www.teses.usp.br/teses/disponiveis/58/58132/tde-29082018-130247/.
Council of Science Editors:
Nobre VV. Impacto do tratamento periodontal não-cirurgico no perfil clínico e imunológico e na colonização oral por Candida spp em indivíduos infectados pelo HIV com periodontite crônica. [Masters Thesis]. University of São Paulo; 2018. Available from: http://www.teses.usp.br/teses/disponiveis/58/58132/tde-29082018-130247/
27.
Thioune, Néné.
Mise au point d’un immunocapteur pour le diagnostic infra-clinique de la maladie parodontale en prothèse fixée : validation d’un protocole de fonctionnalisation d’une surface d’or pour la détection des interleukines 6 et 8 dans le fluide gingival : Development of an immunosensor for subclinical diagnosis of periodontal disease in fixed prosthesis : Validation of a functionalization protocol of a gold surface for detection of pro-inflammatory proteins in the crevicular fluid.
Degree: Docteur es, Physique des matériaux - spécialité Sciences odontologiques, 2015, Sorbonne Paris Cité; Université Cheikh Anta Diop de Dakar
URL: http://www.theses.fr/2015USPCD115
► Introduction. Le contexte de ce travail est le développement d’un capteur visant à détecter des protéines pro-inflammatoires (interleukines : IL-6, IL-8) dans le fluide gingival…
(more)
▼ Introduction. Le contexte de ce travail est le développement d’un capteur visant à détecter des protéines pro-inflammatoires (interleukines : IL-6, IL-8) dans le fluide gingival après pose d’une prothèse unitaire fixée. La détection de ces protéines en faible concentration sera assurée par des phénomènes physiques. Or, ces protéines ne se fixent pas directement sur la surface du capteur et il devient nécessaire de fonctionnaliser la surface. Ce travail préliminaire porte sur la validation du protocole de fonctionnalisation de surface. Matériels et méthodes : Plusieurs stratégies de fonctionnalisation ont été explorées les unes après les autres. Dans un premier temps, l’utilisation des nanobâtonnets d’or ou GNRs utilisés comme capteur sans marquage. L’interaction entre les protéines modèles et les GNRs ont été caractérisé par UV-vis. Dans un second temps, le protocole de fonctionnalisation consiste à accrocher directement les anticorps monoclonaux sur des surfaces d’or ou par l’intermédiaire d’une monocouche auto-assemblée simple (PEG ou DSP) ou mixte (MAU /MOH). Ce protocole a été caractérisé par QCM, SPR et PM-IRRAS et RAMAN.Résultats et conclusions : Les résultats trouvés avec les GNRs sont encourageants et méritent d’être approfondis d’une part et d’autre part les travaux de fonctionnalisation sont plus concluants. Ils ont permis de valider un protocole de fonctionnalisation d’une surface or par une monocouche auto-assemblé mixte couplé au greffage d’anticorps. Ce procédé est plus efficace car la sélectivité et la sensibilité du capteur est plus importante. Ce biocapteur une fois conçu, permet un champ d’application très large en recherche fondamentale et clinique et peut être un nouvel outil diagnostique et pronostique au cabinet dentaire. Il constitue une alternative idéale au test d’ELISA.
Non communiqué
Advisors/Committee Members: Lamy de la Chapelle, Marc (thesis director), Benoist, Henri Michel (thesis director).
Subjects/Keywords: Fluide gingival; Gingival fluid
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APA (6th Edition):
Thioune, N. (2015). Mise au point d’un immunocapteur pour le diagnostic infra-clinique de la maladie parodontale en prothèse fixée : validation d’un protocole de fonctionnalisation d’une surface d’or pour la détection des interleukines 6 et 8 dans le fluide gingival : Development of an immunosensor for subclinical diagnosis of periodontal disease in fixed prosthesis : Validation of a functionalization protocol of a gold surface for detection of pro-inflammatory proteins in the crevicular fluid. (Doctoral Dissertation). Sorbonne Paris Cité; Université Cheikh Anta Diop de Dakar. Retrieved from http://www.theses.fr/2015USPCD115
Chicago Manual of Style (16th Edition):
Thioune, Néné. “Mise au point d’un immunocapteur pour le diagnostic infra-clinique de la maladie parodontale en prothèse fixée : validation d’un protocole de fonctionnalisation d’une surface d’or pour la détection des interleukines 6 et 8 dans le fluide gingival : Development of an immunosensor for subclinical diagnosis of periodontal disease in fixed prosthesis : Validation of a functionalization protocol of a gold surface for detection of pro-inflammatory proteins in the crevicular fluid.” 2015. Doctoral Dissertation, Sorbonne Paris Cité; Université Cheikh Anta Diop de Dakar. Accessed April 15, 2021.
http://www.theses.fr/2015USPCD115.
MLA Handbook (7th Edition):
Thioune, Néné. “Mise au point d’un immunocapteur pour le diagnostic infra-clinique de la maladie parodontale en prothèse fixée : validation d’un protocole de fonctionnalisation d’une surface d’or pour la détection des interleukines 6 et 8 dans le fluide gingival : Development of an immunosensor for subclinical diagnosis of periodontal disease in fixed prosthesis : Validation of a functionalization protocol of a gold surface for detection of pro-inflammatory proteins in the crevicular fluid.” 2015. Web. 15 Apr 2021.
Vancouver:
Thioune N. Mise au point d’un immunocapteur pour le diagnostic infra-clinique de la maladie parodontale en prothèse fixée : validation d’un protocole de fonctionnalisation d’une surface d’or pour la détection des interleukines 6 et 8 dans le fluide gingival : Development of an immunosensor for subclinical diagnosis of periodontal disease in fixed prosthesis : Validation of a functionalization protocol of a gold surface for detection of pro-inflammatory proteins in the crevicular fluid. [Internet] [Doctoral dissertation]. Sorbonne Paris Cité; Université Cheikh Anta Diop de Dakar; 2015. [cited 2021 Apr 15].
Available from: http://www.theses.fr/2015USPCD115.
Council of Science Editors:
Thioune N. Mise au point d’un immunocapteur pour le diagnostic infra-clinique de la maladie parodontale en prothèse fixée : validation d’un protocole de fonctionnalisation d’une surface d’or pour la détection des interleukines 6 et 8 dans le fluide gingival : Development of an immunosensor for subclinical diagnosis of periodontal disease in fixed prosthesis : Validation of a functionalization protocol of a gold surface for detection of pro-inflammatory proteins in the crevicular fluid. [Doctoral Dissertation]. Sorbonne Paris Cité; Université Cheikh Anta Diop de Dakar; 2015. Available from: http://www.theses.fr/2015USPCD115
28.
Τυροβολά, Ιωάννα.
Συσχέτιση επιπέδων SRANKLκαι OPG στον ορό του αίματος και στο υγρό της ουλοδοντικής σχισμής και βαθμού ριζικής απορρόφησης κατά την ορθοδοντική θεραπεία.
Degree: 2009, National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ)
URL: http://hdl.handle.net/10442/hedi/27799
► The aim of the present study was the determination in a rat model of the levels of OPG and sRANKL in blood and in gingival…
(more)
▼ The aim of the present study was the determination in a rat model of the levels of OPG and sRANKL in blood and in gingival crevicular fluid (GCF) in relation to the degree of root resorption during orthodontic tooth movement using healthy experimental animals and a carefully planned and organized experimental design. For this purpose fourteen 6 month old male Wistar rats 350-500 gr weight were used. At a first stage blood samples from the area of the eyes were taken and gingival crevicular fluid (GCF) was collected with the use of paperstrips (penopaper Harco Tustin, CA, USA) from the gingival crevicular area of each upper incisor. Blood samples were also collected after the orthodontic treatment had been completed. A 25gr sentalloy closed orthodontic coil spring(GAC, Ctr Iship, NY, USA) was inserted between the upper right first molar and the upper incisors in all animals. After 21 days of loading a mesial tipping of the right molars was obtained. All night first molars that were moved orthodontically and their cognate left molars (control teeth) were extracted and studied under microcomputed tomography scanning. After studying the extracted teeth the following results were obtained: a) there is a positive linear correlation between the initial concentration of RANKL in blood and the degree of root resorption (r=0.833, p<0.01), b) the ratio of the initial concentrations of OPG/RANKL in blood proved to be an independent prognostic factor of the degree of root resorption after orthodontic therapy (R²=0.87, Adj R²=0.73, Beta=0.872, p<0.01), c) the initial concentration of RANKL in GCF showed a negative correlation to the initial concentration of RANKL in blood serum (r=-0.7, p<0.05), d) it seems that for a concrete group of initial concentrations of OPG/RANKL in GCF, the dental root is protected against extreme external root resorption (R=0.81, p<0.05 for x² η R=0.83, p<0.05 for x³) and finally, e) the concentration of OPG in blood serum decreased significantly in cases of severe root resorption (r=-0.823, p=0.001).
Σκοπός της παρούσας ερευνητικής εργασίας ήταν η διερεύνηση της σχέσεως των επιπέδων της OPG και του s RANKL στο αίμα και στο υγρό της ουλοδοντικής σχισμής σε σχέση με το βαθμό της ριζικής απορρόφησης κατά την ορθοδοντική μετακίνηση των δοντιών. Στην ερευνητική μας εργασία χρησιμοποιήθηκαν 14 υγιείς επίμυες τύπου Wistar 350-500 γρ. περίπου ηλικίας 6 μηνών και όλοι αρσενικού φύλου. Σε κάθε ζώο λήφθηκε δείγμα αίματος πριν και μετά την ορθοδοντική παρέμβαση καθώς επίσης και διπλό (σε ορισμένες περιπτώσεις όπου οι περιοδοντικοί ιστοί δεν ερεθίστηκαν πολύ) δείγμα υγρού από την ουλοδοντική σχισμή του τομέα πριν την ορθοδοντική παρέμβαση. Μετά εφαρμόσθηκε μηχανισμός για την ορθοδοντική μετακίνηση κάθε δεξιού άνω πρώτου γομφίου προς τα εγγύς. Στην αντίθετη πλευρά δηλαδή στην περιοχή του πρώτου άνω γομφίου αριστερά δεν εφαρμόσθηκαν καθόλου ορθοδοντικές δυνάμεις (δόντι έλεγχου). Η ορθοδοντική θεραπεία είχε διάρκεια τριών εβδομάδων. Ακολούθησε αξονική τομογραφία τόσο των δοντιών παρέμβασης όσο και των δοντιών…
Subjects/Keywords: Οστεοπροτεγερίνη; Ριζική απορρόφηση; Ορθοδοντική θεραπεία; Υγρό ουλοδοντικής σχισμής; Ορός αίματος; Οστική αναδιαμόρφωση; Απόπτωση νεογιλού; Πρωτεΐνες; Osteoprotegerin (OPG); Receptor activator of NF-KB ligand (RANKL); Receptor activator of NF-KB (RANK); Root resorption; Orthodontic treatment; Blood serum; Gingival crevicular fluid (GCF); Proteins
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APA (6th Edition):
Τυροβολά, . . (2009). Συσχέτιση επιπέδων SRANKLκαι OPG στον ορό του αίματος και στο υγρό της ουλοδοντικής σχισμής και βαθμού ριζικής απορρόφησης κατά την ορθοδοντική θεραπεία. (Thesis). National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ). Retrieved from http://hdl.handle.net/10442/hedi/27799
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Τυροβολά, Ιωάννα. “Συσχέτιση επιπέδων SRANKLκαι OPG στον ορό του αίματος και στο υγρό της ουλοδοντικής σχισμής και βαθμού ριζικής απορρόφησης κατά την ορθοδοντική θεραπεία.” 2009. Thesis, National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ). Accessed April 15, 2021.
http://hdl.handle.net/10442/hedi/27799.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Τυροβολά, Ιωάννα. “Συσχέτιση επιπέδων SRANKLκαι OPG στον ορό του αίματος και στο υγρό της ουλοδοντικής σχισμής και βαθμού ριζικής απορρόφησης κατά την ορθοδοντική θεραπεία.” 2009. Web. 15 Apr 2021.
Vancouver:
Τυροβολά . Συσχέτιση επιπέδων SRANKLκαι OPG στον ορό του αίματος και στο υγρό της ουλοδοντικής σχισμής και βαθμού ριζικής απορρόφησης κατά την ορθοδοντική θεραπεία. [Internet] [Thesis]. National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ); 2009. [cited 2021 Apr 15].
Available from: http://hdl.handle.net/10442/hedi/27799.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Τυροβολά . Συσχέτιση επιπέδων SRANKLκαι OPG στον ορό του αίματος και στο υγρό της ουλοδοντικής σχισμής και βαθμού ριζικής απορρόφησης κατά την ορθοδοντική θεραπεία. [Thesis]. National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ); 2009. Available from: http://hdl.handle.net/10442/hedi/27799
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Universidade do Estado do Rio de Janeiro
29.
Wilson Rosalem Junior.
Efeito do tratamento periodontal não cirúrgico em pacientes com periodontite crônica e agressiva: achados microbiológicos e imunológicos.
Degree: PhD, 2010, Universidade do Estado do Rio de Janeiro
URL: http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=2599
;
► O objetivo do presente estudo foi comparar a expressão de IL-1β, IL-4, IL-8, interferon-γ, atividade de elastase e a composição do perfil microbiano subgengival antes…
(more)
▼ O objetivo do presente estudo foi comparar a expressão de IL-1β, IL-4, IL-8, interferon-γ, atividade de elastase e a composição do perfil microbiano subgengival antes e depois do tratamento periodontal não cirúrgico em pacientes com doença peridontal crônica generalizada (PC) e agressiva generalizada (PA). Vinte pacientes com PC e quatorze com PA foram avaliados. Dados clínicos, fluido gengival e biofilme subgengival foram analisados na visita inicial (VI) e 3 meses (3M) após o tratamento periodontal não cirúrgico. Amostras de fluido gengival (FG) foram coletadas com tiras de papel e os níveis de: IL-1β, IL-4, IL-8 e INF-γ foram medidos, utilizando um tipo de imunoensaio multiplexado (Luminex). Atividade da elastase foi avaliada por um ensaio enzimático. Amostras de placa subgengival foram analisadas através do checkerboard DNA-DNA hybridization. Na avaliação de 3 meses após terapia periodontal foi encontrado melhora significativa para todos os parâmetros clínicos em ambos os grupos. Foram encontradas reduções significativas na atividade de elastase nos sítios rasos e profundos dos pacientes do grupo PA e nos sítios profundos do grupo PC, também foi achado um aumento significativo de INF-γ nos sítios rasos do grupo PA. Os dados microbiológicos, mostraram reduções significativas para os níveis dos membros do complexo vermelho (P. gingivalis, T. forsythia, T.denticola), e para as espécies E.nodatum e P.micra no grupo PC. No grupo PA, ocorreram reduções significativas no níveis de P. gingivalis, T. forsythia, Fusobacterium nucleatum ss polymorphum e Fusobacterium periodonticum. Quando as respostas clínica e imunológica 3M após terapia foram comparadas entre os grupos, apenas diferenças sutis foram observadas. Nenhuma diferença microbiológica foi encontrada entre os grupos após a terapia. Em conclusão, os achados suportam nossa hipótese de que as periodontites cronica e agressiva respondem de forma semelhante ao tratamento periodontal nao cirúrgico.
Our aim was to compare the expression of IL1β, IL-4, IL-8, INF-γ, elastase activity and the composition of the subgingival microbiota profile before and after non-surgical periodontal treatment in patients with untreated generalized chronic (GCP) and aggressive periodontitis (GAgP). Twenty patients with GCP and 14 with GAgP were evaluated. Clinical data, GCF and plaque were analyzed at baseline and 3 months after non-surgical periodontal treatment. IL-1β, IL-4, IL-8 and INFγ were analyzed in a luminex assay. Elastase activity was assessed by an enzymatic assay. Subgingival plaque samples were analyzed using checkerboard DNA-DNA hybridization. Three months after periodontal therapy significant improvement for all clinical parameters in both groups were found. We have found significant reductions in the elastase activity in shallow and deep sites from GAgP and in deep sites from GCP group. A significant increase in INF-γ in the shallow sites from GAgP group were also found. Microbiological data showed significant reductions…
Advisors/Committee Members: Fabio Ramoa Pires, Jonas Capelli Júnior, Milton de Uzeda, Ricardo Guimarães Fischer, Ricardo Palmier Teles, Carlos Marcelo da Silva Figueredo.
Subjects/Keywords: Periodontite crônica; Periodontite agressiva; Fluido gengival; Citocinas; Microbiota subgengival; Chronic periodontitis; Aggressive periodontitis; Gingival crevicular fluid; Cytokines; Subgingival microbiota; PERIODONTIA; Fluido do sulco gengival - Microbiologia
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APA ·
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APA (6th Edition):
Junior, W. R. (2010). Efeito do tratamento periodontal não cirúrgico em pacientes com periodontite crônica e agressiva: achados microbiológicos e imunológicos. (Doctoral Dissertation). Universidade do Estado do Rio de Janeiro. Retrieved from http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=2599 ;
Chicago Manual of Style (16th Edition):
Junior, Wilson Rosalem. “Efeito do tratamento periodontal não cirúrgico em pacientes com periodontite crônica e agressiva: achados microbiológicos e imunológicos.” 2010. Doctoral Dissertation, Universidade do Estado do Rio de Janeiro. Accessed April 15, 2021.
http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=2599 ;.
MLA Handbook (7th Edition):
Junior, Wilson Rosalem. “Efeito do tratamento periodontal não cirúrgico em pacientes com periodontite crônica e agressiva: achados microbiológicos e imunológicos.” 2010. Web. 15 Apr 2021.
Vancouver:
Junior WR. Efeito do tratamento periodontal não cirúrgico em pacientes com periodontite crônica e agressiva: achados microbiológicos e imunológicos. [Internet] [Doctoral dissertation]. Universidade do Estado do Rio de Janeiro; 2010. [cited 2021 Apr 15].
Available from: http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=2599 ;.
Council of Science Editors:
Junior WR. Efeito do tratamento periodontal não cirúrgico em pacientes com periodontite crônica e agressiva: achados microbiológicos e imunológicos. [Doctoral Dissertation]. Universidade do Estado do Rio de Janeiro; 2010. Available from: http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=2599 ;
Universidade do Estado do Rio de Janeiro
30.
Karina Schittine Bezerra Lomba.
Impacto da terapia mecânica não cirúrgica em pacientes com periodontite crônica e agressiva generalizadas.
Degree: Master, 2010, Universidade do Estado do Rio de Janeiro
URL: http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=2856
;
► O objetivo deste estudo foi avaliar o impacto do tratamento periodontal não cirúrgico sobre a atividade de elastase e o volume de fluido gengival nos…
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▼ O objetivo deste estudo foi avaliar o impacto do tratamento periodontal não cirúrgico sobre a atividade de elastase e o volume de fluido gengival nos pacientes portadores de periodontite crônica e agressiva generalizadas. Foram avaliados 18 pacientes com periodontite crônica (idade média 48,6 DP 7,5 anos), e 11 com periodontite agressiva (idade média 27,9 DP 6,54 anos). Foram utilizados os parâmetros clínicos de avaliação de profundidade de bolsa à sondagem (PB) (mm), nível de inserção (NI) (mm) e sangramento à sondagem (SS). As medidas clínicas e as amostras de fluido gengival foram colhidas a partir dos cinco sítios mais profundos (P) e de cinco sítios rasos com gengivite (G) de cada paciente, antes e 90 dias após o término do tratamento. As etapas clínicas obedeceram ao seguinte cronograma: seleção e exame periodontal; coleta de fluido gengival; tratamento periodontal; reavaliação, compreendendo o exame periodontal e coleta de fluido gengival. O tratamento levou, em média, 4 sessões de 40 minutos cada por paciente, com intervalo de 1 semana entre elas. As consultas para reavaliação foram feitas 90 dias após o término do tratamento. O teste de Wilcoxon foi utilizado para comparar os dados antes e depois do tratamento e o teste não pareado de Mann-Whitney U-test foi utilizado para comparar os grupos de periodontite crônica e agressiva. A amostra analisada antes e após o tratamento não apresentou diferenças significativas entre o grupo com periodontite crônica e agressiva, que responderam de forma similar a todos os indicadores avaliados, exceto para a profundidade de bolsa à sondagem nos sítios rasos com gengivite (p = 0,039) e para o sangramento à sondagem (p = 0,021) nos sítios profundos, ambos mais reduzidos na periodontite crônica após o tratamento. A elastase apresentou, após o tratamento, redução significativa nos sítios profundos, para a periodontite crônica (p = 0,012) e agressiva (p = 0,02). Em relação ao volume de fluido gengival, houve significativa redução após o tratamento nos pacientes com periodontite crônica e agressiva, tanto nos sítios rasos (p = 0,03 e p = 0,03) como nos profundos (p ˂ 0,001 e p = 0,003), respectivamente. Concluindo, os grupos com periodontite crônica e agressiva generalizadas comportaram- se de maneira semelhante frente à terapia mecânica não cirúrgica. Ainda, a terapia periodontal mecânica não cirúrgica mostrou redução significativa do volume de fluido gengival em todos os sítios analisados, e da atividade neutrofílica, nos sítios profundos, associada a reduções significativas em todos os indicadores clínicos analisados após o tratamento.
The aim of this study was to investigate the impact of non-surgical mechanical treatment on elastase activity and gingival crevicular fluids (GCF) volume of patients with untreated generalized chronic and aggressive periodontitis. Eighteen patients with generalized chronic periodontitis (mean age 48,6 SD 7,5 years old) and eleven with generalized aggressive periodontitis (mean age 27,9 SD 6,54 years old) were evaluated. The…
Advisors/Committee Members: Ricardo Guimarães Fischer, Marília da Silva Pereira Bittencourt, Alessandra Areas e Souza, Carlos Marcelo da Silva Figueredo.
Subjects/Keywords: PERIODONTIA; Periodontite crônica; Periodontite agressiva; Elastase neutrofílica; Fluido do sulco gengival; Chronic periodontitis; Aggressive periodontitis; Leukocyte elastase; Gingival crevicular fluid; Periodontite - Tratamento; Elastase de leucócito
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APA (6th Edition):
Lomba, K. S. B. (2010). Impacto da terapia mecânica não cirúrgica em pacientes com periodontite crônica e agressiva generalizadas. (Masters Thesis). Universidade do Estado do Rio de Janeiro. Retrieved from http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=2856 ;
Chicago Manual of Style (16th Edition):
Lomba, Karina Schittine Bezerra. “Impacto da terapia mecânica não cirúrgica em pacientes com periodontite crônica e agressiva generalizadas.” 2010. Masters Thesis, Universidade do Estado do Rio de Janeiro. Accessed April 15, 2021.
http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=2856 ;.
MLA Handbook (7th Edition):
Lomba, Karina Schittine Bezerra. “Impacto da terapia mecânica não cirúrgica em pacientes com periodontite crônica e agressiva generalizadas.” 2010. Web. 15 Apr 2021.
Vancouver:
Lomba KSB. Impacto da terapia mecânica não cirúrgica em pacientes com periodontite crônica e agressiva generalizadas. [Internet] [Masters thesis]. Universidade do Estado do Rio de Janeiro; 2010. [cited 2021 Apr 15].
Available from: http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=2856 ;.
Council of Science Editors:
Lomba KSB. Impacto da terapia mecânica não cirúrgica em pacientes com periodontite crônica e agressiva generalizadas. [Masters Thesis]. Universidade do Estado do Rio de Janeiro; 2010. Available from: http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=2856 ;
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