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Boston University
1.
Poels, Chenin Veronica.
Effect of wireless glucose meter on hyperglycemia and prenatal visits.
Degree: MS, Physician Assistant Program, 2018, Boston University
URL: http://hdl.handle.net/2144/33040 
► Gestational diabetes mellitus can have devastating effects in the health of the mother and child. While pregnancy rates are decreasing, prevalence of GDM is increasing,…
(more)
▼ Gestational diabetes mellitus can have devastating effects in the health of the mother and child. While pregnancy rates are decreasing, prevalence of GDM is increasing, and it is estimated that up to 9% of pregnancies are complicated by
diabetes in the United States. Traditional treatment and monitoring of
gestational diabetes mellitus relies on patient’s compliance to document glycemic levels. This proposed study will evaluate the effectiveness of telemedicine using a wireless glucose meter that transmits information to the providers in real time. The prospective open cohort randomized clinical trial will take place in medical centers around Boston. Two hundred participants diagnosed with
gestational diabetes will be recruited over a period of 24 months from these centers and randomly placed into two groups. One group will follow traditional treatment, and the intervention group will be asked to use iGlucose meter system. Glycemic levels and frequency of prenatal visits will be evaluated and analyzed. If telemedicine proves to be efficacious in treating GDM, this would give providers a new treatment plan to consider to effectively manage blood glucose levels and reduce poor perinatal outcomes related to
gestational diabetes mellitus.
Advisors/Committee Members: Yarrington, Christina (advisor).
Subjects/Keywords: Obstetrics; Gestational diabetes; Mellitus; Telemedicine
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APA (6th Edition):
Poels, C. V. (2018). Effect of wireless glucose meter on hyperglycemia and prenatal visits. (Masters Thesis). Boston University. Retrieved from http://hdl.handle.net/2144/33040
Chicago Manual of Style (16th Edition):
Poels, Chenin Veronica. “Effect of wireless glucose meter on hyperglycemia and prenatal visits.” 2018. Masters Thesis, Boston University. Accessed January 18, 2021.
http://hdl.handle.net/2144/33040.
MLA Handbook (7th Edition):
Poels, Chenin Veronica. “Effect of wireless glucose meter on hyperglycemia and prenatal visits.” 2018. Web. 18 Jan 2021.
Vancouver:
Poels CV. Effect of wireless glucose meter on hyperglycemia and prenatal visits. [Internet] [Masters thesis]. Boston University; 2018. [cited 2021 Jan 18].
Available from: http://hdl.handle.net/2144/33040.
Council of Science Editors:
Poels CV. Effect of wireless glucose meter on hyperglycemia and prenatal visits. [Masters Thesis]. Boston University; 2018. Available from: http://hdl.handle.net/2144/33040
Louisiana State University
2.
Wang, Yujie.
A Cohort Study of a History of Gestational Diabetes Mellitus and the Risk of Incident Type 2 Diabetes in Louisiana Women.
Degree: MS, Human Ecology, 2011, Louisiana State University
URL: etd-07012011-144141
;
https://digitalcommons.lsu.edu/gradschool_theses/178
► Gestational diabetes mellitus (GDM) is one of the most common pregnancy complications. It has been shown that a history of GDM is associated with an…
(more)
▼ Gestational diabetes mellitus (GDM) is one of the most common pregnancy complications. It has been shown that a history of GDM is associated with an increased risk of incident type 2 diabetes in women. In this project, we aim to investigate 1) the trend of GDM incidence in Louisiana State University Health Care Services Division (LSUHCSD) hospital system during 1997 to 2009; 2) the race-specific association between a history of GDM and the risk of incident type 2 diabetes and how the risk changes over years after the index pregnancy. We conducted a retrospective study among women aged 13-50 years. Pregnancies, GDM cases and type 2 diabetes cases were identified by using the International Classification of Disease (ICD) -9 code from the Louisiana State University Hospital-Based Longitudinal Study (LSUHLS) database. The annual incidence of GDM and it standard error (SE) were calculated. Cox proportional hazards regression models were used to estimate the association of a history of GDM with the risk of incident type 2 diabetes. The association between previous GDM and the risk of type 2 diabetes in different postpartum periods was examined using logistic regression. The incidence of GDM increased in most years from 1997 to 2009 and reached a peak in 2002. The incidence of GDM increased with age and reached the peak at 35-39 years of age. Among the three study races, Asians had a significantly higher incidence of GDM than Whites and African Americans. Between 1990 and 2009, 1,142 GDM women and 18,856 non-GDM women presented their first record of pregnancy in the LSUHLS database. During a mean follow-up of 8.6 years, 1,067 women without a history of GDM and 327 women with a history of GDM developed type 2 diabetes. The multivariable-adjusted (age, smoking, income, postpartum body mass index (BMI), postpartum systolic blood pressure, and race) hazard ratio of type 2 diabetes suggested that a history of GDM is a strong predictor of subsequent type 2 diabetes among Louisiana women, especially among African American women. In addition, risk of type 2 diabetes was decreased by the time after the index delivery.
Subjects/Keywords: gestational diabetes mellitus; type 2 diabetes; Louisiana
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APA (6th Edition):
Wang, Y. (2011). A Cohort Study of a History of Gestational Diabetes Mellitus and the Risk of Incident Type 2 Diabetes in Louisiana Women. (Masters Thesis). Louisiana State University. Retrieved from etd-07012011-144141 ; https://digitalcommons.lsu.edu/gradschool_theses/178
Chicago Manual of Style (16th Edition):
Wang, Yujie. “A Cohort Study of a History of Gestational Diabetes Mellitus and the Risk of Incident Type 2 Diabetes in Louisiana Women.” 2011. Masters Thesis, Louisiana State University. Accessed January 18, 2021.
etd-07012011-144141 ; https://digitalcommons.lsu.edu/gradschool_theses/178.
MLA Handbook (7th Edition):
Wang, Yujie. “A Cohort Study of a History of Gestational Diabetes Mellitus and the Risk of Incident Type 2 Diabetes in Louisiana Women.” 2011. Web. 18 Jan 2021.
Vancouver:
Wang Y. A Cohort Study of a History of Gestational Diabetes Mellitus and the Risk of Incident Type 2 Diabetes in Louisiana Women. [Internet] [Masters thesis]. Louisiana State University; 2011. [cited 2021 Jan 18].
Available from: etd-07012011-144141 ; https://digitalcommons.lsu.edu/gradschool_theses/178.
Council of Science Editors:
Wang Y. A Cohort Study of a History of Gestational Diabetes Mellitus and the Risk of Incident Type 2 Diabetes in Louisiana Women. [Masters Thesis]. Louisiana State University; 2011. Available from: etd-07012011-144141 ; https://digitalcommons.lsu.edu/gradschool_theses/178
Boston University
3.
Crocker, Audrey.
Recurrent gestational diabetes mellitus: the effect of a lifestyle intervention.
Degree: MS, Physician Assistant Program, 2018, Boston University
URL: http://hdl.handle.net/2144/32966
► Gestational diabetes mellitus (GDM) is the most common complication of pregnancy that affects 1-14% of all pregnancies. If not properly managed, GDM can be a…
(more)
▼ Gestational diabetes mellitus (GDM) is the most common complication of pregnancy that affects 1-14% of all pregnancies. If not properly managed, GDM can be a devastating disease, leading to birth complications such as shoulder dystocia and neonatal hypoglycemia. GDM has many long-term implications as well, such as increased risk of obesity and type 2
diabetes mellitus (T2DM) in both the mother and the offspring. Additionally, women with a history of GDM are at increased risk of recurrent GDM in a subsequent pregnancy and multiple episodes of GDM further increases a woman’s risk for these short and long-term consequences. For this reason, a diagnosis of GDM provides an opportunity to target GDM and T2DM risk factors to prevent recurrence of GDM and halt the
diabetes disease course. Research has shown that diet and physical activity interventions provided after a pregnancy complicated by GDM can delay or prevent the onset of T2DM yet literature on prevention of recurrent GDM is lacking.
This thesis will propose a new intervention applied to the inter-pregnancy interval (IPI), designed to reduce incidence of recurrent GDM. The study will examine the effect of a diet and physical activity intervention for women with a recent pregnancy complicated by GDM on recurrence in a subsequent pregnancy and weight gain in the IPI. We hypothesize that our intervention will reduce incidence of GDM recurrence compared to the control group and that women in the intervention group will lose more weight compared to women in the control group. The results of this study will provide a background for further study on the prevention of GDM recurrence with the hope that prevention of recurrent GDM will prevent the short and long-term sequela of GDM.
Advisors/Committee Members: Lee-Parritz, Aviva (advisor).
Subjects/Keywords: Medicine; Diabetes; Gestational diabetes mellitus; Recurrent gestational diabetes
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APA (6th Edition):
Crocker, A. (2018). Recurrent gestational diabetes mellitus: the effect of a lifestyle intervention. (Masters Thesis). Boston University. Retrieved from http://hdl.handle.net/2144/32966
Chicago Manual of Style (16th Edition):
Crocker, Audrey. “Recurrent gestational diabetes mellitus: the effect of a lifestyle intervention.” 2018. Masters Thesis, Boston University. Accessed January 18, 2021.
http://hdl.handle.net/2144/32966.
MLA Handbook (7th Edition):
Crocker, Audrey. “Recurrent gestational diabetes mellitus: the effect of a lifestyle intervention.” 2018. Web. 18 Jan 2021.
Vancouver:
Crocker A. Recurrent gestational diabetes mellitus: the effect of a lifestyle intervention. [Internet] [Masters thesis]. Boston University; 2018. [cited 2021 Jan 18].
Available from: http://hdl.handle.net/2144/32966.
Council of Science Editors:
Crocker A. Recurrent gestational diabetes mellitus: the effect of a lifestyle intervention. [Masters Thesis]. Boston University; 2018. Available from: http://hdl.handle.net/2144/32966
University of Alberta
4.
Beka, Qendresa.
Gestational Diabetes Mellitus and Mental Illness in
Alberta.
Degree: MS, Department of Public Health Sciences, 2016, University of Alberta
URL: https://era.library.ualberta.ca/files/cwp988k027
► Introduction: Research has shown a bidirectional relationship between type 2 diabetes and mental illness, and worse health outcomes for patients with both illnesses than those…
(more)
▼ Introduction: Research has shown a bidirectional
relationship between type 2 diabetes and mental illness, and worse
health outcomes for patients with both illnesses than those with
either condition alone. However, there is limited research on the
relationship between mental illness and gestational diabetes
mellitus (GDM), and their impact on future health outcomes. This
thesis investigated three questions: (1) the impact of GDM on the
development of mental illness during pregnancy and post-partum; (2)
the impact of mental illness prior to pregnancy on the development
of GDM in pregnancy; and (3) the impact of GDM, mental illness, and
both illnesses on the development of type 2 diabetes, hypertension
and cardiovascular disease (CVD). Methods: Administrative data from
a population perinatal health registry was linked to physician
claims, hospitalization records and outpatient visits to identify
diagnosis of mental illness, diabetes, hypertension and
cardiovascular disease among women who delivered in Alberta, Canada
between April 1, 1999 and March 31, 2010. For the first study,
generalized estimating equations (GEE) were used to determine the
odds ratios of developing a mental illness during pregnancy and
post-partum among women with GDM. GEE was also used for the second
study, determining the odds ratio of GDM comparing women with and
without a history of mental illness. The third study used
cumulative incidence curves and cox proportional hazards to compare
the development of diabetes, hypertension and cardiovascular
disease among women with the following conditions during pregnancy:
no GDM or mental illness, mental illness only, GDM only, or both
GDM and mental illness. Results: GDM in pregnancy was not
associated with diagnosis of incident mental illness in pregnancy
(OR=1.06, 95%CI=0.98,1.13) or post-partum (OR=1.03,
95%CI=0.97,1.10). Theodds of developing GDM was higher for women
with a history of mental illness than without (OR=1.10,
95%CI=1.06,1.14). Women with both GDM and mental illness had the
highest hazard rates for diabetes (22.4, 95%CI=19.2, 26.1),
hypertension (2.0, 95%CI=1.7,2.3) and CVD (1.7, 95%CI=0.9,3.4).
Women with GDM only had a significantly higher risk of diabetes
(20.5, 95%CI=18.4, 22.9) and hypertension (1.7, 95%CI=1.6, 1.9)
than women with mental illness (1.3, 95%CI=1.1, 1.5) and (1.1,
95%CI=1.1,1.2) respectfully. The risk for cardiovascular disease
was higher for women with only mental illness (1.6, 95%CI=1.3, 1.9)
than those with only GDM (1.5, 95%CI=1.0, 2.3). Conclusion: GDM
does not increase the risk of developing a mental illness in
pregnancy or post-partum. However, women with a history of mental
disorders prior to pregnancy have an increased risk of GDM. GDM and
mental illness in pregnancy each result in increased rates of
chronic disease and the highest risk is for women with both GDM and
mental illness.
Subjects/Keywords: GDM; gestational diabetes mellitus; mental illness; perinatal
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APA (6th Edition):
Beka, Q. (2016). Gestational Diabetes Mellitus and Mental Illness in
Alberta. (Masters Thesis). University of Alberta. Retrieved from https://era.library.ualberta.ca/files/cwp988k027
Chicago Manual of Style (16th Edition):
Beka, Qendresa. “Gestational Diabetes Mellitus and Mental Illness in
Alberta.” 2016. Masters Thesis, University of Alberta. Accessed January 18, 2021.
https://era.library.ualberta.ca/files/cwp988k027.
MLA Handbook (7th Edition):
Beka, Qendresa. “Gestational Diabetes Mellitus and Mental Illness in
Alberta.” 2016. Web. 18 Jan 2021.
Vancouver:
Beka Q. Gestational Diabetes Mellitus and Mental Illness in
Alberta. [Internet] [Masters thesis]. University of Alberta; 2016. [cited 2021 Jan 18].
Available from: https://era.library.ualberta.ca/files/cwp988k027.
Council of Science Editors:
Beka Q. Gestational Diabetes Mellitus and Mental Illness in
Alberta. [Masters Thesis]. University of Alberta; 2016. Available from: https://era.library.ualberta.ca/files/cwp988k027
University of Manchester
5.
Hulme, Charlotte.
Understanding placental function in pregnancies complicated by diabetes mellitus : a systems biology approach.
Degree: PhD, 2016, University of Manchester
URL: https://www.research.manchester.ac.uk/portal/en/theses/understanding-placental-function-in-pregnancies-complicated-by-diabetes-mellitus-a-systems-biology-approach(3af489f0-82c7-4f0d-8735-0dda3b8f007a).html
;
http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.677833
► Pregnancies complicated with diabetes mellitus (DM) are associated with poor maternal and fetal outcomes, such as birth trauma, fetal overgrowth (macrosomia) and programming of the…
(more)
▼ Pregnancies complicated with diabetes mellitus (DM) are associated with poor maternal and fetal outcomes, such as birth trauma, fetal overgrowth (macrosomia) and programming of the fetus to develop metabolic syndrome in adult life. Maternal hyperglycemia is thought to contribute to fetal macrosomia, however the role of the placenta in these pregnancies is incompletely understood, therefore we aimed to investigate the specific consequences of high glucose on placental metabolism. To achieve this aim an in vitro model of placental exposure to high glucose was developed. This model was used with the aim of analysing how high glucose alters the transcriptome and metabolome of these cells, using a systems biology approach to identify candidate functional pathways which may be altered in placenta as a result of hyperglycemia. These candidate functional pathways were validated in an ex vivo model of placenta exposed to high glucose and in placental tissue from pregnancies complicated by DM. A trophoblast cell line (BeWo) was cultured in low (5 mM) and high (12 mM or 25 mM) D-glucose conditions for 48 hours. Transcriptomic and metabolomic analysis of these cells was performed using microarrays, and gas- and liquid-chromatography-mass spectrometry, respectively. Transcript and metabolite changes were independently analysed and integrated, using network analysis. From the integrated analysis of the ‘omic datasets, β-fatty acid oxidation (β-FAO), purine metabolism, phosphatidylinositol/PI3K phosphate pathway and lipid metabolism, were identified as candidates for further study. Changes within the PI3K pathway and lipid metabolism/β-fatty acid oxidation were validated in an ex vivo placental explant model of high glucose and in placental tissue from women with DM, compared to uncomplicated pregnancies. mRNA, protein expression and protein activation of key molecules within the PI3K pathway were not significantly altered in placenta as a response of high glucose ex vivo or DM in vivo. The second candidate functional pathway, lipid metabolism, has previously been implicated in association with placental dysfunction in pregnancies complicated by DM. Placental fatty acid transporter and lipase protein expression, as well as, relative abundance of different fatty acids were unaltered in response to high glucose or DM. High glucose levels increased triglyceride levels within the placenta, indicating reduced rates of β-FAO. The effect of high glucose could be ameliorated using a PPARα agonist. This may provide a novel therapeutic intervention to prevent excess esterification of fatty acids to triglycerides in maternal diabetes, which may in turn influence fetal growth. This study illustrates how a systems biology approach can be used to identify novel candidate functional pathways that are altered within the trophoblast in response to high glucose. Thus, improving understanding of placental dysfunction in these pregnancies and providing novel candidate pathways for future study, which may represent potential therapeutic targets for…
Subjects/Keywords: 618.3; Diabetes mellitus; Placenta; Pregnancy; Gestational diabetes; Hyperglycemia; Systems biology
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APA (6th Edition):
Hulme, C. (2016). Understanding placental function in pregnancies complicated by diabetes mellitus : a systems biology approach. (Doctoral Dissertation). University of Manchester. Retrieved from https://www.research.manchester.ac.uk/portal/en/theses/understanding-placental-function-in-pregnancies-complicated-by-diabetes-mellitus-a-systems-biology-approach(3af489f0-82c7-4f0d-8735-0dda3b8f007a).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.677833
Chicago Manual of Style (16th Edition):
Hulme, Charlotte. “Understanding placental function in pregnancies complicated by diabetes mellitus : a systems biology approach.” 2016. Doctoral Dissertation, University of Manchester. Accessed January 18, 2021.
https://www.research.manchester.ac.uk/portal/en/theses/understanding-placental-function-in-pregnancies-complicated-by-diabetes-mellitus-a-systems-biology-approach(3af489f0-82c7-4f0d-8735-0dda3b8f007a).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.677833.
MLA Handbook (7th Edition):
Hulme, Charlotte. “Understanding placental function in pregnancies complicated by diabetes mellitus : a systems biology approach.” 2016. Web. 18 Jan 2021.
Vancouver:
Hulme C. Understanding placental function in pregnancies complicated by diabetes mellitus : a systems biology approach. [Internet] [Doctoral dissertation]. University of Manchester; 2016. [cited 2021 Jan 18].
Available from: https://www.research.manchester.ac.uk/portal/en/theses/understanding-placental-function-in-pregnancies-complicated-by-diabetes-mellitus-a-systems-biology-approach(3af489f0-82c7-4f0d-8735-0dda3b8f007a).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.677833.
Council of Science Editors:
Hulme C. Understanding placental function in pregnancies complicated by diabetes mellitus : a systems biology approach. [Doctoral Dissertation]. University of Manchester; 2016. Available from: https://www.research.manchester.ac.uk/portal/en/theses/understanding-placental-function-in-pregnancies-complicated-by-diabetes-mellitus-a-systems-biology-approach(3af489f0-82c7-4f0d-8735-0dda3b8f007a).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.677833
University of Wollongong
6.
Cinnadaio, Nancy.
Dietary change after gestational diabetes
mellitus for prevention of type two diabetes
mellitus.
Degree: Masters of Science -
Research, 2013, University of Wollongong
URL: 1111
NUTRITION
AND
DIETETICS
;
https://ro.uow.edu.au/theses/4435
► Women with a history of gestational diabetes mellitus (GDM) are at an increased risk of developing type two diabetes mellitus (T2DM). Nutritional guidelines for…
(more)
▼ Women with a history of
gestational diabetes mellitus (GDM) are at an increased
risk of developing type two diabetes mellitus (T2DM).
Nutritional guidelines for the prevention of T2DM
recommend a reduction of 7% of body weight if overweight,
reduction in the intake of fat and an increase in the
intake of dietary fibre. Current research indicates
overweight and obesity and consumption of excessive
dietary fat, are prevalent problems amongst women with
prior GDM. Thus, there is a need to develop interventions
targeted towards lifestyle change in these women. This
thesis is a secondary analysis of dietary data from a
pilot behavioural lifestyle intervention in women with
prior GDM: the Healthy Living Program after Gestational
Diabetes Mellitus (HeLP GDM) study. The following two
central hypotheses were tested: 1.
dietary change was achieved in the HeLP GDM
study 2. the associated dietary
intakes collected from two dietary assessment methods
provided relatively comparable estimates of macronutrient
intake. Methods: In the HeLP GDM study
59 overweight or obese women with prior GDM were
randomised to either a six month telephone diet and
physical activity behavioural change intervention group
or a no treatment control group. For this thesis changes
in intake of energy, fat and fibre from baseline to six
months were analysed using nutrient estimates obtained
from three day estimated food records and seven day
telephone diet histories. Additionally change in body
weight from baseline to six months was assessed using
selfreported weight. To assess relative validity baseline
diet history and food record paired data were compared
for group differences. Change in bias from baseline to
six months was assessed using paired t tests with
individual precision and presence of systematic error
determined by Bland Altman scatterplots.
Results: At six months diet history analysis
demonstrated the intervention group compared to the
control group reduced energy by -1251 kJ (95%CI -2169,
-332), total fat by -16.8 g (95% CI -28.5, -5.0) and
saturated fat by -7.2 g (95% CI -12.2, -2.1). Analysis of
food record data demonstrated only a relative reduction
in saturated fat of -4.7 g (95% CI -9.0, -0.4) in the
intervention group. The reduction in energy by -849 kJ
(95% CI -1774, 76) and total fat by - 11.5 kJ (95% CI
-23.2, 0.2) approached but failed to achieve statistical
significance. Intervention participants were more likely
than control participants to consume an intake of total
fat less than ≤30 of total energy [9.2 greater odds (95%
…
Subjects/Keywords: Gestational diabetes mellitus; prevention; type two diabetes mellitus; diet; lifestyle; fat; fibre; diet history
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APA ·
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Manager
APA (6th Edition):
Cinnadaio, N. (2013). Dietary change after gestational diabetes
mellitus for prevention of type two diabetes
mellitus. (Masters Thesis). University of Wollongong. Retrieved from 1111 NUTRITION AND DIETETICS ; https://ro.uow.edu.au/theses/4435
Chicago Manual of Style (16th Edition):
Cinnadaio, Nancy. “Dietary change after gestational diabetes
mellitus for prevention of type two diabetes
mellitus.” 2013. Masters Thesis, University of Wollongong. Accessed January 18, 2021.
1111 NUTRITION AND DIETETICS ; https://ro.uow.edu.au/theses/4435.
MLA Handbook (7th Edition):
Cinnadaio, Nancy. “Dietary change after gestational diabetes
mellitus for prevention of type two diabetes
mellitus.” 2013. Web. 18 Jan 2021.
Vancouver:
Cinnadaio N. Dietary change after gestational diabetes
mellitus for prevention of type two diabetes
mellitus. [Internet] [Masters thesis]. University of Wollongong; 2013. [cited 2021 Jan 18].
Available from: 1111 NUTRITION AND DIETETICS ; https://ro.uow.edu.au/theses/4435.
Council of Science Editors:
Cinnadaio N. Dietary change after gestational diabetes
mellitus for prevention of type two diabetes
mellitus. [Masters Thesis]. University of Wollongong; 2013. Available from: 1111 NUTRITION AND DIETETICS ; https://ro.uow.edu.au/theses/4435
University of Helsinki
7.
Järvinen, Ilkka.
Memory functions in adults with a history of prenatal hyperglycaemia and/or neonatal hypoglycaemia.
Degree: Medicinska fakulteten, 2017, University of Helsinki
URL: http://hdl.handle.net/10138/181437
► Sekä syntymää edeltävä hyperglykemia (joka liittyy raskaudenaikaiseen diabetekseen) että vastasyntyneen hypoglykemia ovat riskitekijöitä lapsen neurokognitiiviselle kehitykselle: Äidin raskaudenaikaisen diabeteksen on raportoitu olevan yhteydessä häiriöihin jälkeläisten…
(more)
▼ Sekä syntymää edeltävä hyperglykemia (joka liittyy raskaudenaikaiseen diabetekseen) että vastasyntyneen hypoglykemia ovat riskitekijöitä lapsen neurokognitiiviselle kehitykselle: Äidin raskaudenaikaisen diabeteksen on raportoitu olevan yhteydessä häiriöihin jälkeläisten muistitoiminnoissa, aina nuoruusikään asti. Vastasyntyneen hypoglykemian on myös raportoitu olevan yhteydessä hermoston kehityksen häiriöihin, samoin nuoruusikään asti. Syntymää edeltävän hyperglykemian yhteyttä muistin ongelmiin ei kuitenkaan tietääksemme ole aiemmin tutkittu aikuisilla. Vastasyntyneen hypoglykemian yhteyttä muistin ongelmiin ei puolestaan ole tietääksemme tutkittu missään ikävaiheessa. Myöskään näiden riskitekijöiden erillisiä ja yhteisvaikutuksia ei ole aiemmin suoraan vertailtu. Hypoteesimme oli, että nämä riskitekijät, yhdessä ja erikseen, olisivat vielä keski-iässäkin yhteydessä lieviin muistiongelmiin.
Tutkimme muistitoimintoja vuosina 1971–1974 syntyneen kohortin seurantatutkimuksessa. Kohorttia oli seurattu prospektiivisesti syntymästä lähtien. Tutkimuksen osallistujat olivat altistuneet syntymää edeltävälle hyperglykemialle (n = 22), vastasyntyneen hypoglykemialle (n = 14) tai molemmille (n = 7). Tutkimukseen osallistui myös kontrolleja, joilla ei ollut varhaisia riskitekijöitä (n = 40). Kartoitimme kattavasti osallistujien muistitoimintoja, mukaan lukien työmuistia sekä kielellisen ja näönvaraisen aineksen välitöntä ja viivästettyä mieleenpalautusta.
Havaitsimme yhdysvaikutuksen varhaisen riskin ja työmuistia mittaavan numerosarjatehtävän tyypin välillä: erot numerosarjatehtävien välillä vaihtelivat ryhmien välillä. Kuitenkaan mitkään parittaiset erot ryhmien välillä eivät olleet merkitseviä. Siten interaktio ei liittynyt mihinkään tiettyihin ryhmiin eikä luultavasti myöskään ollut kliinisesti merkittävä. Interaktio ei ollut merkitsevä, kun gestaatioikä ja syntymäpaino kontrolloitiin. Tutkimamme varhaiset riskit eivät olleet yhteydessä muiden muistitehtävien tuloksiin.
Hypoteesiemme vastaisesti tuloksemme viittaavat siihen, että syntymää edeltävä hyperglykemia, vastasyntyneen hypoglykemia ja niiden yhdistelmä ovat verrattain hyvänlaatuisia häiriöitä, etenkin silloin, kun muita syntymään liittyviä riskitekijöitä ei ole: syntymää edeltävän hyperglykemian yhteys neurokognitiivisiin haittoihin vaikuttaa tasoittuvan aikuisuuteen mennessä. Vastasyntyneen hypoglykemialla taas ei vaikuta olevan juurikaan pitkäaikaisia haittavaikutuksia.
Subjects/Keywords: diabetes mellitus; pregnancy; gestational diabetes mellitus; neonatal hypoglycaemia; memory; middle age; Psychology; Psykologia; Psykologi
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APA (6th Edition):
Järvinen, I. (2017). Memory functions in adults with a history of prenatal hyperglycaemia and/or neonatal hypoglycaemia. (Masters Thesis). University of Helsinki. Retrieved from http://hdl.handle.net/10138/181437
Chicago Manual of Style (16th Edition):
Järvinen, Ilkka. “Memory functions in adults with a history of prenatal hyperglycaemia and/or neonatal hypoglycaemia.” 2017. Masters Thesis, University of Helsinki. Accessed January 18, 2021.
http://hdl.handle.net/10138/181437.
MLA Handbook (7th Edition):
Järvinen, Ilkka. “Memory functions in adults with a history of prenatal hyperglycaemia and/or neonatal hypoglycaemia.” 2017. Web. 18 Jan 2021.
Vancouver:
Järvinen I. Memory functions in adults with a history of prenatal hyperglycaemia and/or neonatal hypoglycaemia. [Internet] [Masters thesis]. University of Helsinki; 2017. [cited 2021 Jan 18].
Available from: http://hdl.handle.net/10138/181437.
Council of Science Editors:
Järvinen I. Memory functions in adults with a history of prenatal hyperglycaemia and/or neonatal hypoglycaemia. [Masters Thesis]. University of Helsinki; 2017. Available from: http://hdl.handle.net/10138/181437
University of New South Wales
8.
Shahid, Farhana.
Understanding psycho-social factors influencing lifestyle of women with a history of gestational diabetes in Pakistan.
Degree: Community Medicine, 2012, University of New South Wales
URL: http://handle.unsw.edu.au/1959.4/52619
;
https://unsworks.unsw.edu.au/fapi/datastream/unsworks:11292/SOURCE01?view=true
► Lifestyle interventions are proven to be effective in preventing or delaying type 2 diabetes mellitus (T2DM) in high risk individuals, such as women with a…
(more)
▼ Lifestyle interventions are proven to be effective in preventing or delaying type 2
diabetes mellitus (T2DM) in high risk individuals, such as women with a history of
gestational diabetes mellitus (GDM) referred to henceforth as GDM women. This thesis was designed to address the lack of understanding of factors that affect lifestyle of GDM women in Pakistan and identify suitable approaches for intervention. A series of studies were conducted to develop valid and reliable measures for constructs in the trans-theoretical model (TTM), family support and diet and to test a model for lifestyle change. The study participants were recruited from a tertiary care hospital in Karachi, Pakistan. The qualitative study used in-depth interviews (n=24) and group discussions (n=17) and was analysed thematically. Measures were developed and tested in a cross sectional survey of post-natal women (n=331). Exploratory factor analysis was used to examine the construct validity of measures and Partial least Square (PLS) to predict diet and physical activity of GDM women in Pakistan. The qualitative findings revealed lack of knowledge, social support, cultural expectations and gender role as influencing lifestyle of GDM women. Variables that included TTM constructs (pros and cons, self efficacy and stages of change), family support and selected demographic factors predicted 44 percent of variance in dietary fat intake and 38 percent of physical activity of GDM women. These models explained much less of the variance in non-GDM women. Self-efficacy, cons for change and positive family support were the most significant predicators of dietary behaviour. Self-efficacy and cons for change were significant predictors of physical activity. This study makes an original contribution to the gap in knowledge of factors that affect lifestyle behaviours of GDM women in a South Asian context, and specifically Pakistan. The findings indicate that interventions for GDM women using strategies to improve self efficacy, addressing perceived cons, and using family support would be effective. Culturally specific messages, delivered by a health care provider targeting weight management would be acceptable for GDM women in Pakistan. The findings inform the design of a lifestyle intervention for this target group.
Advisors/Committee Members: Jayasuriya, Rohan, Public Health & Community Medicine, Faculty of Medicine, UNSW, Razee, Husna, Public Health & Community Medicine, Faculty of Medicine, UNSW, Iqbal, Romaina, Department of Community Health Sciences, The Aga Khan University, Karachi, Pakistan.
Subjects/Keywords: Prevention of Type 2 diabetes mellitus; Gestational Diabetes Mellitus; Pakistan; Lifestyle; Psycho-social factors
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APA (6th Edition):
Shahid, F. (2012). Understanding psycho-social factors influencing lifestyle of women with a history of gestational diabetes in Pakistan. (Doctoral Dissertation). University of New South Wales. Retrieved from http://handle.unsw.edu.au/1959.4/52619 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:11292/SOURCE01?view=true
Chicago Manual of Style (16th Edition):
Shahid, Farhana. “Understanding psycho-social factors influencing lifestyle of women with a history of gestational diabetes in Pakistan.” 2012. Doctoral Dissertation, University of New South Wales. Accessed January 18, 2021.
http://handle.unsw.edu.au/1959.4/52619 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:11292/SOURCE01?view=true.
MLA Handbook (7th Edition):
Shahid, Farhana. “Understanding psycho-social factors influencing lifestyle of women with a history of gestational diabetes in Pakistan.” 2012. Web. 18 Jan 2021.
Vancouver:
Shahid F. Understanding psycho-social factors influencing lifestyle of women with a history of gestational diabetes in Pakistan. [Internet] [Doctoral dissertation]. University of New South Wales; 2012. [cited 2021 Jan 18].
Available from: http://handle.unsw.edu.au/1959.4/52619 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:11292/SOURCE01?view=true.
Council of Science Editors:
Shahid F. Understanding psycho-social factors influencing lifestyle of women with a history of gestational diabetes in Pakistan. [Doctoral Dissertation]. University of New South Wales; 2012. Available from: http://handle.unsw.edu.au/1959.4/52619 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:11292/SOURCE01?view=true
University of Guelph
9.
Carty, Adele Pauline.
Child Health in the Province of Ontario: Establishing baselines for reproductive health and vaccine preventable diseases.
Degree: MS, Department of Population Medicine, 2015, University of Guelph
URL: https://atrium.lib.uoguelph.ca/xmlui/handle/10214/9182
► This thesis was an investigation of child health in the province of Ontario through the lens of reproductive health, and vaccine preventable diseases (VPD). Two…
(more)
▼ This thesis was an investigation of child health in the province of Ontario through the lens of reproductive health, and vaccine preventable diseases (VPD). Two studies were conducted; the first examined the association between pre-pregnancy BMI and the risk of developing
gestational diabetes mellitus (GDM) and
gestational hypertension (GH) in a rural Southern Ontario community hospital. In multivariable logistic regression, pre-pregnancy BMI was significantly associated with the risk of developing both GDM and GH. The second study examined immunization compliance for measles, mumps, and rubella among children seven years of age residing in the city of Guelph. A significant difference was identified in overall immunization compliance to National Advisory Committee on Immunization Standards (NACI) between the city of Guelph’s priority neighbourhoods, and non-priority neighbourhoods. These findings will aid in identifying populations at risk for the development of poor child health outcomes, for whom public health initiatives should be targeted.
Advisors/Committee Members: Papadopoulos, Andrew (advisor).
Subjects/Keywords: gestational diabetes mellitus; gestational hypertension; pre-pregnancy body mass index; measles; mumps; rubella; vaccine compliance
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APA (6th Edition):
Carty, A. P. (2015). Child Health in the Province of Ontario: Establishing baselines for reproductive health and vaccine preventable diseases. (Masters Thesis). University of Guelph. Retrieved from https://atrium.lib.uoguelph.ca/xmlui/handle/10214/9182
Chicago Manual of Style (16th Edition):
Carty, Adele Pauline. “Child Health in the Province of Ontario: Establishing baselines for reproductive health and vaccine preventable diseases.” 2015. Masters Thesis, University of Guelph. Accessed January 18, 2021.
https://atrium.lib.uoguelph.ca/xmlui/handle/10214/9182.
MLA Handbook (7th Edition):
Carty, Adele Pauline. “Child Health in the Province of Ontario: Establishing baselines for reproductive health and vaccine preventable diseases.” 2015. Web. 18 Jan 2021.
Vancouver:
Carty AP. Child Health in the Province of Ontario: Establishing baselines for reproductive health and vaccine preventable diseases. [Internet] [Masters thesis]. University of Guelph; 2015. [cited 2021 Jan 18].
Available from: https://atrium.lib.uoguelph.ca/xmlui/handle/10214/9182.
Council of Science Editors:
Carty AP. Child Health in the Province of Ontario: Establishing baselines for reproductive health and vaccine preventable diseases. [Masters Thesis]. University of Guelph; 2015. Available from: https://atrium.lib.uoguelph.ca/xmlui/handle/10214/9182
University of Kentucky
10.
Roberson, Lauren Brinkman.
EXAMINING REASONS FOR LOW FIDELITY TO EDUCATIONAL PROGRAMS IN PATIENTS WITH GESTATIONAL DIABETES: A QUALITATIVE STUDY.
Degree: 2014, University of Kentucky
URL: https://uknowledge.uky.edu/foodsci_etds/18
► Gestational diabetes mellitus (GDM) is an increasing problem in the U.S. Many comorbidities are associated with GDM: increased risk for type 2 diabetes, neonatal hypoglycemia…
(more)
▼ Gestational diabetes mellitus (GDM) is an increasing problem in the U.S. Many comorbidities are associated with GDM: increased risk for type 2 diabetes, neonatal hypoglycemia and fetal malformation. Healthcare organizations develop GDM educational programs to provide women with knowledge and skills to manage GDM and reduce health risks. While there are significant benefits to attending GDM educational programs, attendance rates are low. Little research has been conducted to determine reasons for low attendance in GDM educational programs. The purpose of this study was to explore the experiences of women with GDM and to describe factors influencing GDM educational program attendance. Semi-structured telephone interviews were conducted with GDM program participants at a large hospital in central Kentucky. The sample size was N=21. Results indicated that meal management changes and blood glucose monitoring characterized the GDM experience and many attended the educational program to receive information on these topics. Few participants reported barriers to attendance. The majority was satisfied with information received. Motivators to attendance included flexibility, location, and support of family members.. Participants preferred face-to-face meetings although some expressed a need for online classes and communication via text messaging. Participants expressed the need for GDM information postpartum.
Subjects/Keywords: gestational diabetes mellitus; gestational diabetes educational programs; attendance; diabetes educators; qualitative research; Dietetics and Clinical Nutrition
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APA (6th Edition):
Roberson, L. B. (2014). EXAMINING REASONS FOR LOW FIDELITY TO EDUCATIONAL PROGRAMS IN PATIENTS WITH GESTATIONAL DIABETES: A QUALITATIVE STUDY. (Masters Thesis). University of Kentucky. Retrieved from https://uknowledge.uky.edu/foodsci_etds/18
Chicago Manual of Style (16th Edition):
Roberson, Lauren Brinkman. “EXAMINING REASONS FOR LOW FIDELITY TO EDUCATIONAL PROGRAMS IN PATIENTS WITH GESTATIONAL DIABETES: A QUALITATIVE STUDY.” 2014. Masters Thesis, University of Kentucky. Accessed January 18, 2021.
https://uknowledge.uky.edu/foodsci_etds/18.
MLA Handbook (7th Edition):
Roberson, Lauren Brinkman. “EXAMINING REASONS FOR LOW FIDELITY TO EDUCATIONAL PROGRAMS IN PATIENTS WITH GESTATIONAL DIABETES: A QUALITATIVE STUDY.” 2014. Web. 18 Jan 2021.
Vancouver:
Roberson LB. EXAMINING REASONS FOR LOW FIDELITY TO EDUCATIONAL PROGRAMS IN PATIENTS WITH GESTATIONAL DIABETES: A QUALITATIVE STUDY. [Internet] [Masters thesis]. University of Kentucky; 2014. [cited 2021 Jan 18].
Available from: https://uknowledge.uky.edu/foodsci_etds/18.
Council of Science Editors:
Roberson LB. EXAMINING REASONS FOR LOW FIDELITY TO EDUCATIONAL PROGRAMS IN PATIENTS WITH GESTATIONAL DIABETES: A QUALITATIVE STUDY. [Masters Thesis]. University of Kentucky; 2014. Available from: https://uknowledge.uky.edu/foodsci_etds/18
11.
Spaulonci, Cristiane Pavão.
Comparação entre a metformina e a insulina no tratamento do diabetes gestacional: ensaio clínico randomizado.
Degree: Mestrado, Obstetrícia e Ginecologia, 2012, University of São Paulo
URL: http://www.teses.usp.br/teses/disponiveis/5/5139/tde-25042012-093028/
;
► Objetivo: Avaliar o controle glicêmico em pacientes que utilizaram metformina ou insulina para tratamento do diabetes gestacional, identificando fatores preditores da necessidade de insulina complementar…
(more)
▼ Objetivo: Avaliar o controle glicêmico em pacientes que utilizaram metformina ou insulina para tratamento do diabetes gestacional, identificando fatores preditores da necessidade de insulina complementar nas pacientes que tiveram, como terapêutica inicial, a metformina. Método: pacientes com DG que não obtiveram controle glicêmico com dieta e exercícios físicos foram randomizadas para receber metformina (n=46) ou insulina (n=46). Os critérios de inclusão foram: gestação única, realização de dieta e exercícios físicos por período mínimo de uma semana, sem controle glicêmico satisfatório, ausência de fatores de risco para acidose láctica, ausência de anormalidades anatômicas e/ou cromossômicas do produto conceptual. Foram excluídas as gestantes que apresentaram perda de seguimento pré-natal. Resultado: A comparação das médias glicêmicas pré-tratamento medicamentoso não mostrou diferença estatisticamente significativa entre os grupos (p=0,790). Porém, após a introdução dos medicamentos, foram observados médias glicêmicas menores no grupo metformina, ao longo do dia (p=0,020), principalmente, após o jantar (p=0,042). Pacientes que utilizaram metformina tiveram menor ganho de peso (p=0,002) e, também, menor frequência de hipoglicemia neonatal (p=0,032). Doze pacientes do grupo metformina (26,08%) necessitaram de insulina complementar para controle glicêmico. A idade gestacional precoce (odds ratio 0,71, CI95% 0,52-0,97; p=0,032) e a média glicêmica pré-tratamento medicamentoso (odds ratio 1,061, CI95% 1,001-1,124; p=0,046) foram identificadas como preditoras da necessidade de insulina complementar. Conclusão: A metformina foi eficaz em propiciar controle glicêmico adequado, com menor ganho de peso e menor frequência de hipoglicemia neonatal. Foi identificado grupo de pacientes com maior probabilidade de necessitar de complementação com insulina para atingir controle glicêmico
Objective: To evaluate glycemic control in women receiving metformin or insulin for the treatment of gestational diabetes, and to identify factors predicting the need for supplemental insulin in women initially treated with metformin. Methods: Women with gestational diabetes who did not achieve glycemic control with diet and exercise were randomized to receive either metformin (n=46) or insulin (n=46). Criteria for inclusion were singleton pregnancy, diet and exercise for a minimum period of one week without satisfactory glycemic control, absence of risk factors for lactic acidosis, and absence of anatomic and/or chromosome anomalies of the conceptus. Patients who were lost to prenatal follow-up were excluded. Results: Comparison of mean pretreatment glucose levels showed no significant difference between groups (P=.790). However, lower mean glucose levels across the day were observed in the metformin group after introduction of the drug (P=.020), especially after dinner (P=.042). Women using metformin presented less weight gain (P=.002) and a lower frequency of neonatal hypoglycemia (P=.032). Twelve women in the metformin group (26.08%) required…
Advisors/Committee Members: Francisco, Rossana Pulcineli Vieira.
Subjects/Keywords: Diabetes gestacional; Diabetes mellitus; Diabetes mellitus; Ensaio clínico controlado e randomizado; Gestação; Gestational diabetes; Metformin; Metformina; Pregnancy; Randomized clinical trial
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APA ·
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APA (6th Edition):
Spaulonci, C. P. (2012). Comparação entre a metformina e a insulina no tratamento do diabetes gestacional: ensaio clínico randomizado. (Masters Thesis). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/5/5139/tde-25042012-093028/ ;
Chicago Manual of Style (16th Edition):
Spaulonci, Cristiane Pavão. “Comparação entre a metformina e a insulina no tratamento do diabetes gestacional: ensaio clínico randomizado.” 2012. Masters Thesis, University of São Paulo. Accessed January 18, 2021.
http://www.teses.usp.br/teses/disponiveis/5/5139/tde-25042012-093028/ ;.
MLA Handbook (7th Edition):
Spaulonci, Cristiane Pavão. “Comparação entre a metformina e a insulina no tratamento do diabetes gestacional: ensaio clínico randomizado.” 2012. Web. 18 Jan 2021.
Vancouver:
Spaulonci CP. Comparação entre a metformina e a insulina no tratamento do diabetes gestacional: ensaio clínico randomizado. [Internet] [Masters thesis]. University of São Paulo; 2012. [cited 2021 Jan 18].
Available from: http://www.teses.usp.br/teses/disponiveis/5/5139/tde-25042012-093028/ ;.
Council of Science Editors:
Spaulonci CP. Comparação entre a metformina e a insulina no tratamento do diabetes gestacional: ensaio clínico randomizado. [Masters Thesis]. University of São Paulo; 2012. Available from: http://www.teses.usp.br/teses/disponiveis/5/5139/tde-25042012-093028/ ;
University of Adelaide
12.
Han, Shanshan.
Dietary and lifestyle advice for women to prevent and treat pregnancy hyperglycaemia: identifying and closing research gaps.
Degree: 2014, University of Adelaide
URL: http://hdl.handle.net/2440/119558
► Background Increased glycaemia during pregnancy is associated with adverse health outcomes for women and their babies. This thesis aimed to investigate and evaluate the strategies…
(more)
▼ Background Increased glycaemia during pregnancy is associated with adverse health outcomes for women and their babies. This thesis aimed to investigate and evaluate the strategies used for preventing, diagnosing and managing pregnancy hyperglycaemia. Methods Research methodologies used included Cochrane systematic review, qualitative semi-structured interview and a follow-up cohort study of women and babies within a randomised trial. Results Three Cochrane systematic reviews were conducted in identified research gaps. The first review assessed the effects of physical exercise for preventing
gestational diabetes mellitus (GDM). Evidence from five randomised controlled trials involving 922 women and their babies suggested no differences in the incidence of GDM, caesarean section or operative vaginal birth between women who received additional exercise interventions and those having routine antenatal care. The second review assessed nine randomised trials involving 429 women and 436 babies investigated eleven different types of dietary advice within six different comparisons. No one type of dietary advice was more effective than others in reducing the risk of caesarean section, operative vaginal birth, large-for-
gestational age or macrosomic infants. The third review assessed the effects of different types of management strategies for pregnant women with borderline GDM. Evidence from four randomised controlled trials involving 521 women and their babies suggested additional interventions, including dietary counselling and metabolic monitoring, helped reduce the number of macrosomic and large-for-
gestational-age babies without increasing the risks of caesarean section or operative vaginal birth. All three systematic reviews highlighted the need for further, larger, well-designed trials. The qualitative semi-structured interview study explored women’s views on their diagnosis and management for borderline GDM. Twenty-two women attended the interviews. The diagnosis of borderline GDM caused concern for one third of women. The majority of women believed managing their borderline GDM was important and they planned to improve their lifestyle. Factors affecting women’s ability to achieve intended lifestyle changes varied greatly. The most important enabler was thinking about baby’s health. The most significant barrier was a lack of family support. The follow-up cohort study within a randomised trial followed 245 mother-baby pairs at four to 12 months after birth to assess their health. Additional lifestyle interventions during pregnancy for women with borderline GDM had no impact on primary outcomes of maternal weight retention at four months postpartum or their babies’ weight at four to 12 months of age, or any secondary outcomes, except infant subcutaneous adiposity at four months of age. Conclusion Synthesis of available evidence on different strategies for preventing and managing pregnancy hyperglycaemia does not yet permit clear guidance for clinical practice but indicates the need for further trials with long-term follow…
Advisors/Committee Members: Crowther, Caroline (advisor), Middleton, Philippa (advisor), School of Paediatrics and Reproductive Health (school).
Subjects/Keywords: pregnancy hyperglycaemia; gestational diabetes mellitus; prevention; treatment; diet; exercise; lidestyle
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APA ·
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Manager
APA (6th Edition):
Han, S. (2014). Dietary and lifestyle advice for women to prevent and treat pregnancy hyperglycaemia: identifying and closing research gaps. (Thesis). University of Adelaide. Retrieved from http://hdl.handle.net/2440/119558
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Han, Shanshan. “Dietary and lifestyle advice for women to prevent and treat pregnancy hyperglycaemia: identifying and closing research gaps.” 2014. Thesis, University of Adelaide. Accessed January 18, 2021.
http://hdl.handle.net/2440/119558.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Han, Shanshan. “Dietary and lifestyle advice for women to prevent and treat pregnancy hyperglycaemia: identifying and closing research gaps.” 2014. Web. 18 Jan 2021.
Vancouver:
Han S. Dietary and lifestyle advice for women to prevent and treat pregnancy hyperglycaemia: identifying and closing research gaps. [Internet] [Thesis]. University of Adelaide; 2014. [cited 2021 Jan 18].
Available from: http://hdl.handle.net/2440/119558.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Han S. Dietary and lifestyle advice for women to prevent and treat pregnancy hyperglycaemia: identifying and closing research gaps. [Thesis]. University of Adelaide; 2014. Available from: http://hdl.handle.net/2440/119558
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
AUT University
13.
Bristow, Sarah Marie.
Toddler food and activity patterns and body composition: a study of the offspring of mothers treated for gestational diabetes mellitus
.
Degree: 2010, AUT University
URL: http://hdl.handle.net/10292/1010
► Accumulation of excess body fat tracks from an early age and interventions aimed at preventing childhood obesity may need to begin early in life, particularly…
(more)
▼ Accumulation of excess body fat tracks from an early age and interventions aimed at preventing childhood obesity may need to begin early in life, particularly for children exposed to
gestational diabetes mellitus (GDM). There is evidence from animal studies food and activity patterns in offspring may be programmed by an adverse intrauterine environment, however evidence of an effect in humans is lacking. The ethnic diversity of young people in New Zealand is increasing but little is known with respect to the early life ethnic differences in food and activity patterns and body composition. Understanding differences may help explain the genesis of ethnic disparity in the prevalence of obesity and associated health conditions The primary aim of this study was to examine and compare food and activity patterns and body composition in a sample of 147 children at the mid-toddler stage of development. The average age was 27.7 months and 48 European (F 26; M 28), 41 Polynesian (F 22; M 19), 36 Indian (F 17; M 19), 18 Asian (F 12; M 6) and 4 Other (F 3; M 1) children were studied. Because the children in this study were born to mothers treated for GDM, the effects of maternal glucose control and GDM treatment (metformin versus insulin) on food and activity patterns were also examined. Food and activity data were collected by a food frequency questionnaire, 24-hour food recall and a 24-hour activity recall. Body composition was measured using anthropometry, bioimpedance analysis (BIA) and dual-energy x-ray absorptiometry (DEXA) when possible. DEXA scans were used to validate a BIA equation to predict fat free mass. When compared with the Ministry of Health (MoH) nutritional guidelines, two-thirds of toddlers did not consume breads and cereals four or more time per day, and one-third and one-quarter did not consume fruit and vegetables twice a day respectively. Three-quarters of toddlers consumed treat foods at least once a day, and takeaways at least twice a week and more than two-thirds consumed sweet drinks at least once a day. Toddlers slept on average 12.5 hours per 24 hour period, watched 1.0 hour of television, and played actively for almost 5.0 hours. Overall girls had a higher fatness (3%) than boys. No associations between food and activity patterns and body composition at 2 years of age were found, and no associations between maternal glucose control, GDM treatment (metformin versus insulin) or food and activity patterns at 2 years of age were found. Marked ethnic differences in food and activity patterns and body composition were found. Specifically: - Less Indian children consumed fruit twice a day and meat once a day than European children, and more Polynesian children consumed takeaways at least five times a week than European children. - Polynesian, Asian and Indian toddlers slept for 1.0 hour less than European toddlers and watched around 0.5 hours more television per day. - Polynesian toddlers were taller and heavier than other ethnic groups and had on average 2% more body fat than European toddlers. - After…
Advisors/Committee Members: Rush, Elaine (advisor), Rowan, Janet (advisor).
Subjects/Keywords: Toddler;
Obesity;
Nutrition;
Physical activity;
Gestational diabetes mellitus;
Children
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Manager
APA (6th Edition):
Bristow, S. M. (2010). Toddler food and activity patterns and body composition: a study of the offspring of mothers treated for gestational diabetes mellitus
. (Thesis). AUT University. Retrieved from http://hdl.handle.net/10292/1010
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Bristow, Sarah Marie. “Toddler food and activity patterns and body composition: a study of the offspring of mothers treated for gestational diabetes mellitus
.” 2010. Thesis, AUT University. Accessed January 18, 2021.
http://hdl.handle.net/10292/1010.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Bristow, Sarah Marie. “Toddler food and activity patterns and body composition: a study of the offspring of mothers treated for gestational diabetes mellitus
.” 2010. Web. 18 Jan 2021.
Vancouver:
Bristow SM. Toddler food and activity patterns and body composition: a study of the offspring of mothers treated for gestational diabetes mellitus
. [Internet] [Thesis]. AUT University; 2010. [cited 2021 Jan 18].
Available from: http://hdl.handle.net/10292/1010.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Bristow SM. Toddler food and activity patterns and body composition: a study of the offspring of mothers treated for gestational diabetes mellitus
. [Thesis]. AUT University; 2010. Available from: http://hdl.handle.net/10292/1010
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Univerzitet u Beogradu
14.
Stefanović, Tomislav Ž., 1963-.
Korelacija ultrazvučnih pokazatelja fetalne makrozomijei
parametara kontrole glikemije u trudnoći.
Degree: Medicinski fakultet, 2016, Univerzitet u Beogradu
URL: https://fedorabg.bg.ac.rs/fedora/get/o:12566/bdef:Content/get
► Medicina - Humana reprodukcija / Medicine - Human reproduction
Cilj: Makrozomija i trudnički šećer (GDM) su poslednjih decenija rastući problem akušera, a njihova prevencija, dijagnostika…
(more)
▼ Medicina - Humana reprodukcija / Medicine - Human
reproduction
Cilj: Makrozomija i trudnički šećer (GDM) su
poslednjih decenija rastući problem akušera, a njihova prevencija,
dijagnostika i adekvatno praćenje su postali standard adekvatne
prenatalne nege. To omogućava pravovremeno reagovanje akušera i
sprečavanje komplikacija. Ova dva važna patološka entiteta su
međusobno povezana mnogobrojnim zajedničkim patofiziološkim
procesima, a GDM je najčešći i najpreventabilniji uzrok makrozomije
ploda. Novije studije pokazuju da je ultrazvuk moćno sredstvo
akušera u otkrivanju makrozomije i GDM-a. Međutim, u dosadašnjim
istraživanjima se radilo o studijama preseka, a ne o prospektivnim
studijama, koje bi evaluacijom ultrazvučnih parametara u predikciji
ovih entiteta u različitim periodima trudnoće dale odgovor o
optimalnom, a što ranijem periodu trudnoće za ultrazvučnu detekciju
makrozomije i GDMa. Zato je cilj disertacije bio da se u različitim
periodima trudnoće odrede optimalne granične vrednosti ultrazvučnih
markera koje bi služile za otkrivanje GDM-a i makrozomije ploda. On
je podrazumevao i ispitivanje dijagnostičke validnosti evaluiranih
ultrazvučnih markera glikoregulacije trudnica, a u koje spadaju
količina plodove vode (AFI), debljina potkožnog masnog tkiva na
nivou stomaka fetusa (ASCT), dužina fetalne jetre (LL) i obim
fetalnog stomaka (AC), u otkrivanju makrozomije ploda i trudničkog
šećera. Metodologija: Prospektivna kohortna studija izvedena je u
Bolnici za ginekologiju i akušerstvo Kliničko-bolničkog centra
„Zemun“ i u Institutu za ginekologiju i akušerstvo, Kliničkog
centra Srbije, u periodu od januara 2013. godine do oktobra 2013.
godine. Disertacija je obuhvatila 528 trudnica sa jednoplodnom
trudnoćom i najmanje jednim prisutnim faktorom rizika GDM, upućenih
na redovan ultrazvučni pregled u 23. nedelji trudnoće (n.g.).
Nedelju dana nakon inicijalnog ultrazvučnog pregleda, koji je
obuhvatao merenje AC, ASCT i AFI, trudnice su podvrgnute oralnom
testu opterećenja sa 100 g glukoze (OGTT), „zlatnom“ dijagnostičkom
standardu za GDM. Ultrazvučni pregledi su ponavljani u 28. nedelji,
32. nedelji i konačno u 36. nedelji trudnoće. Analizirane su one
trudnice kojima su obavljeni svi predviđeni ultrazvučni pregledi po
studijskom protokolu i koje su se porodile nakon 36. n.g. u
ustanovama u kojima je istraživanje obavljeno...
Advisors/Committee Members: Gojnić Dugalić, Miroslava, 1968-.
Subjects/Keywords: Gestational diabetes mellitus; macrosomy; ultrasound;
fetal liver; fetal adipose tissue
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APA (6th Edition):
Stefanović, Tomislav Ž., 1. (2016). Korelacija ultrazvučnih pokazatelja fetalne makrozomijei
parametara kontrole glikemije u trudnoći. (Thesis). Univerzitet u Beogradu. Retrieved from https://fedorabg.bg.ac.rs/fedora/get/o:12566/bdef:Content/get
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Stefanović, Tomislav Ž., 1963-. “Korelacija ultrazvučnih pokazatelja fetalne makrozomijei
parametara kontrole glikemije u trudnoći.” 2016. Thesis, Univerzitet u Beogradu. Accessed January 18, 2021.
https://fedorabg.bg.ac.rs/fedora/get/o:12566/bdef:Content/get.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Stefanović, Tomislav Ž., 1963-. “Korelacija ultrazvučnih pokazatelja fetalne makrozomijei
parametara kontrole glikemije u trudnoći.” 2016. Web. 18 Jan 2021.
Vancouver:
Stefanović, Tomislav Ž. 1. Korelacija ultrazvučnih pokazatelja fetalne makrozomijei
parametara kontrole glikemije u trudnoći. [Internet] [Thesis]. Univerzitet u Beogradu; 2016. [cited 2021 Jan 18].
Available from: https://fedorabg.bg.ac.rs/fedora/get/o:12566/bdef:Content/get.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Stefanović, Tomislav Ž. 1. Korelacija ultrazvučnih pokazatelja fetalne makrozomijei
parametara kontrole glikemije u trudnoći. [Thesis]. Univerzitet u Beogradu; 2016. Available from: https://fedorabg.bg.ac.rs/fedora/get/o:12566/bdef:Content/get
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Manitoba
15.
Rogers, Colleen Kem.
Calcium and vitamin D nutrition during pregnancy: a survey of family physicians and a chart review of pregnant women with gestational diabetes mellitus.
Degree: Human Nutritional Sciences, 2015, University of Manitoba
URL: http://hdl.handle.net/1993/31051
► Introduction: Adequate calcium and vitamin D are needed for maternal and fetal health. Many pregnant women are not consuming enough calcium and are at high…
(more)
▼ Introduction: Adequate calcium and vitamin D are needed for maternal and fetal health. Many pregnant women are not consuming enough calcium and are at high risk for vitamin D deficiency. Objectives: To 1) investigate the nutrition-related knowledge, opinions, and clinical practices of family physicians (FPs) towards prenatal calcium and vitamin D; and 2) determine the prevalence of meeting a predefined cut-off serum 25-hydroxyvitamin D concentration ([25-OHD]) for vitamin D sufficiency (≥ 75 nmol/L) in a cohort of pregnant women with
gestational diabetes mellitus (GDM). Methods: Part 1: 500 surveys were mailed out to randomly selected FPs across Manitoba. Part 2: data were collected via retrospective chart review of 35 pregnant women with GDM attending a teaching hospital in Winnipeg, Manitoba between January 1, 2010 and December 31, 2013 and having one serum [25-OHD] measurement during their pregnancy. Results: Approximately one-third of FPs are discussing calcium and vitamin D requirements and supplements with their prenatal patients. The top three perceived barriers to delivery of calcium and vitamin D advice were more urgent issues, lack of time, and forgetting to do so. The mean serum [25-OHD] was 52.5 ± 24.1 nmol/L (range 14-109 nmol/L). Over half of women (51.4%) were vitamin D deficient ([25-OHD] < 50 nmol/L), and 28.6% of women were insufficient ([25-OHD] 50-74 nmol/L). Conclusions: Physicians would benefit from more training in nutrition. Multiple barriers exist that prevent FPs from providing calcium and vitamin D advice. Women with GDM have a high prevalence of vitamin D deficiency in our study.
Advisors/Committee Members: Taylor, Carla (Human Nutritional Sciences) (supervisor), Aliani, Michel (Human Nutritional Sciences) Salamon, Elizabeth (Community Health Sciences) (examiningcommittee).
Subjects/Keywords: Vitamin D; Calcium; Pregnancy; Gestational diabetes mellitus; Manitoba
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APA (6th Edition):
Rogers, C. K. (2015). Calcium and vitamin D nutrition during pregnancy: a survey of family physicians and a chart review of pregnant women with gestational diabetes mellitus. (Masters Thesis). University of Manitoba. Retrieved from http://hdl.handle.net/1993/31051
Chicago Manual of Style (16th Edition):
Rogers, Colleen Kem. “Calcium and vitamin D nutrition during pregnancy: a survey of family physicians and a chart review of pregnant women with gestational diabetes mellitus.” 2015. Masters Thesis, University of Manitoba. Accessed January 18, 2021.
http://hdl.handle.net/1993/31051.
MLA Handbook (7th Edition):
Rogers, Colleen Kem. “Calcium and vitamin D nutrition during pregnancy: a survey of family physicians and a chart review of pregnant women with gestational diabetes mellitus.” 2015. Web. 18 Jan 2021.
Vancouver:
Rogers CK. Calcium and vitamin D nutrition during pregnancy: a survey of family physicians and a chart review of pregnant women with gestational diabetes mellitus. [Internet] [Masters thesis]. University of Manitoba; 2015. [cited 2021 Jan 18].
Available from: http://hdl.handle.net/1993/31051.
Council of Science Editors:
Rogers CK. Calcium and vitamin D nutrition during pregnancy: a survey of family physicians and a chart review of pregnant women with gestational diabetes mellitus. [Masters Thesis]. University of Manitoba; 2015. Available from: http://hdl.handle.net/1993/31051
Iowa State University
16.
Clark, Kendra Leah.
Deciphering the ovarian proteomic impacts of obesity.
Degree: 2019, Iowa State University
URL: https://lib.dr.iastate.edu/etd/17659
► The ovary is the female reproductive organ responsible for the production of both the female gamete, the oocyte, and two major female sex hormones, estradiol…
(more)
▼ The ovary is the female reproductive organ responsible for the production of both the female gamete, the oocyte, and two major female sex hormones, estradiol and progesterone. During embryonic development, oocytes are formed from primordial germ cells and eventually become surrounded by squamous granulosa cells in a follicular structure, termed primordial. The oocyte numbers encased in primordial follicles are finite at birth and remain arrested in the diplotene stage of meiosis until ovulation or they degenerate through atresia. Once the pool of primordial follicles is depleted, ovarian senescence occurs. We hypothesized that the maternal metabolic changes that occur during lean gestational diabetes mellitus would impact offspring ovarian function both basally and in response to a dietary stressor later in life. We observed impacts on follicle numbers and alterations in the ovarian proteome, suggesting possible impacts on fertility and oocyte quality in relation to in utero and metabolic stressors. Additionally, we hypothesized that the ovarian DNA damage response is altered during obesity in adulthood. An elevated response in markers of DNA damage was observed, indicating that the metabolic status of the ovary during obesity initiates a low-level DNA damage response. Intercellular communication is also affected by a metabolic syndrome such as obesity or GDM exposure, with reduction of the gap junction protein Connexin-43 expression in antral follicles from ovaries that experienced obesity. Finally, to elucidate the molecular mechanisms behind the induction of the DNA damage response in the ovary after phosphoramide mustard exposure, we hypothesized that the DNA damage response would be blunted due to reduced abundance of the ATM protein. Using an Atm+/- mouse model to investigate impacts on folliculogenesis and the ovarian proteome, we determined that Atm haploinsufficiency results in an irregular DNA damage response, alters the ovarian proteome, and impacts the rate of follicle loss after phosphoramide mustard exposure. Taken together, these findings demonstrate that the DNA damage response is initiated in the ovary during times of metabolic stress and in the absence of Atm, unhealthy follicles remain in the ovary, potentially contributing to poor oocyte quality or infertility.
Subjects/Keywords: gap junction; gestational diabetes mellitus; obesity; oncofertility; ovary; Genetics
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APA (6th Edition):
Clark, K. L. (2019). Deciphering the ovarian proteomic impacts of obesity. (Thesis). Iowa State University. Retrieved from https://lib.dr.iastate.edu/etd/17659
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Clark, Kendra Leah. “Deciphering the ovarian proteomic impacts of obesity.” 2019. Thesis, Iowa State University. Accessed January 18, 2021.
https://lib.dr.iastate.edu/etd/17659.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Clark, Kendra Leah. “Deciphering the ovarian proteomic impacts of obesity.” 2019. Web. 18 Jan 2021.
Vancouver:
Clark KL. Deciphering the ovarian proteomic impacts of obesity. [Internet] [Thesis]. Iowa State University; 2019. [cited 2021 Jan 18].
Available from: https://lib.dr.iastate.edu/etd/17659.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Clark KL. Deciphering the ovarian proteomic impacts of obesity. [Thesis]. Iowa State University; 2019. Available from: https://lib.dr.iastate.edu/etd/17659
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
17.
Gizeli de Fátima Ribeiro dos Anjos.
Dopplervelocimetria da artéria oftálmica em gestantes com diabetes mellitus gestacional.
Degree: 2012, Federal University of Uberlândia
URL: http://www.bdtd.ufu.br//tde_busca/arquivo.php?codArquivo=4220
► To evaluate the patterns of the ophthalmic artery Doppler velocimetry in pregnant women with gestational diabetes mellitus (GDM), comparing them with those found in normal…
(more)
▼ To evaluate the patterns of the ophthalmic artery Doppler velocimetry in pregnant women with gestational diabetes mellitus (GDM), comparing them with those found in normal pregnant women. This is an observational study that examined the ophthalmic artery Doppler indices in two groups: one consisting of 40 pregnant women diagnosed with GDM and the other for 40 normal pregnant women, treated at the Hospital Clinics of the Federal University of Uberlândia. The study was approved by the Ethics Committee and Research institution under the number 293/10. The patients underwent Doppler ultrasound of the ophthalmic artery from 27 weeks. The variables analyzed were: pulsatility index (PI), resistance index (RI), peak velocity ratio (PVR), peak systolic velocity (PSV) and end distolic velocity (EDV). To analyze the normality of the samples was used Lillefors test and Studentst- tests and Mann-Whitney test to compare means and medians, as data normality. The significance level used was of 95%. The mean age of pregnant women with GDM was 30,0 5,5 years and pregnant women at 24,2 5,5 years. The mean gestational ages were 33,7 2,7 weeks and 33, 9 2,7 weeks in groups of GDM and normal pregnant women. There was no significant difference between the mean gestational age between the two groups analyzed (p = 0,701). The median and mean values with standard deviation of the variables of the ophthalmic artery Doppler group GDM and normal pregnant women were: PI = 1,68 0,60 / 1,64 0,46 (p = 0,695); RI = 0,75 / 0,75 (p = 0,980); RPV = 0,54 0,11 / 0,50 0,11 (p=0,117); PVS(cm/s)= 33,05 / 31,91 (p=0,721) e EDV(cm/s)= 6,24 / 7,89 (p=0,485). Twenty-six patients (65%) underwent mapping of the retina with normal results. There were no significant changes in flow patterns of ophthalmic arteries in the group of pregnant women with GDM, showing that the time of exposure to the disease during pregnancy was short to cause significant vascular disorders within central.
Avaliar os padrões dopplervelocimétricos da artéria oftálmica em portadoras de Diabetes Mellitus Gestacional (DMG), comparando-os com os achados em gestantes normais. Trata-se de um estudo observacional que analisou os índices Doppler das artérias oftálmicas em dois grupos: um constituído por 40 gestantes com diagnóstico de DMG e o outro por 40 gestantes normais, atendidas no Hospital das Clínicas da Universidade federal de Uberlândia. O estudo foi aprovado pelo Comitê de Ética e Pesquisa da Instituição sob o número 293/10. As pacientes foram submetidas a ultrassom com Doppler da artéria oftálmica a partir de 27 semanas. As variáveis analisadas foram: índice de pulsatilidade (IP), índice de resistência (IR), razão entre picos de velocidade (RPV), pico de velocidade sistólica (PVS) e velocidade diastólica final (VDF). Para análise de normalidade das amostras, foram empregados o teste de Lillefors e os testes t student e Mann-Whitney para comparação entre as médias e medianas, conforme normalidade dos dados. O nível de significância empregado foi de 95%. A idade média das gestantes com…
Advisors/Committee Members: Maria Celia dos Santos, Angélica Lemos Debs Diniz, Miguel Hernandes Neto, Adriana Wagner.
Subjects/Keywords: Dopplervelocimetria; Artéria oftálmica; Diabetes mellitus; Gestacional; CIENCIAS DA SAUDE; Ciências médicas; Diabetes; Artérias; Mulheres grávidas; Doppler; Ophthalmic artery; Gestational diabetes mellitus.
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APA (6th Edition):
Anjos, G. d. F. R. d. (2012). Dopplervelocimetria da artéria oftálmica em gestantes com diabetes mellitus gestacional. (Thesis). Federal University of Uberlândia. Retrieved from http://www.bdtd.ufu.br//tde_busca/arquivo.php?codArquivo=4220
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Anjos, Gizeli de Fátima Ribeiro dos. “Dopplervelocimetria da artéria oftálmica em gestantes com diabetes mellitus gestacional.” 2012. Thesis, Federal University of Uberlândia. Accessed January 18, 2021.
http://www.bdtd.ufu.br//tde_busca/arquivo.php?codArquivo=4220.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Anjos, Gizeli de Fátima Ribeiro dos. “Dopplervelocimetria da artéria oftálmica em gestantes com diabetes mellitus gestacional.” 2012. Web. 18 Jan 2021.
Vancouver:
Anjos GdFRd. Dopplervelocimetria da artéria oftálmica em gestantes com diabetes mellitus gestacional. [Internet] [Thesis]. Federal University of Uberlândia; 2012. [cited 2021 Jan 18].
Available from: http://www.bdtd.ufu.br//tde_busca/arquivo.php?codArquivo=4220.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Anjos GdFRd. Dopplervelocimetria da artéria oftálmica em gestantes com diabetes mellitus gestacional. [Thesis]. Federal University of Uberlândia; 2012. Available from: http://www.bdtd.ufu.br//tde_busca/arquivo.php?codArquivo=4220
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
18.
Abreu, Laísa Ribeiro Silva de.
Composição corporal de recém-nascidos e de mães com diabetes mellitus gestacional e de recém-nascidos e mães com tolerância normal à glicose.
Degree: Mestrado, Nutrição em Saúde Pública, 2014, University of São Paulo
URL: http://www.teses.usp.br/teses/disponiveis/6/6138/tde-04112014-101809/
;
► Introdução - Em 2012, a Federação Internacional de Diabetes relatou haver no mundo mais de 371 milhões de pessoas diagnosticadas com Diabetes Mellitus. O Brasil…
(more)
▼ Introdução - Em 2012, a Federação Internacional de Diabetes relatou haver no mundo mais de 371 milhões de pessoas diagnosticadas com Diabetes Mellitus. O Brasil ocupa o 3o lugar neste ranking, devido à urbanização crescente, inatividade física e ao aumento do consumo de alimentos com altas densidades energéticas, gordura saturada, açúcar e sal. O subgrupo de gestantes acometidas por Diabetes Mellitus Gestacional (DMG) (7,6 por cento ), ganha destaque, uma vez que sua incidência acompanha o aumento de sobrepeso e obesidade em mulheres em idade fértil. O ambiente intraútero está alterado nesta condição metabólica, sendo um fator determinante na deposição de gordura fetal. Por sua vez, a porcentagem de gordura corporal de recém-nascidos (RNs) de mães com DMG ultrapassa a faixa de normalidade, expondo a prole a riscos em curto e longo prazo. Objetivo - Comparar medidas antropométricas e composição corporal de RNs e mães portadoras de diabetes mellitus gestacional com as de RNs e mães com tolerância normal à glicose. Métodos - Este estudo caso-controle foi realizado no Hospital Municipal e Maternidade Escola Dr Mário de Moraes Altenfelder Silva - Vila Nova Cachoeirinha e comparou as composições corporais de 62 pares de RNs a termo e mães portadoras de DMG com as de 211 pares de RNs a termo e mães com tolerância normal à glicose (TNG), obtidas através de pletismografia por deslocamento de ar e bioimpedância segmentada, respectivamente. Para detectar diferenças estatisticamente significativas foram utilizados os testes T-Student e Chiquadrado (X²), considerando-se um nível de significância de 5 por cento . Resultados Não houve diferença estatisticamente significativa (p<0,05) entre RNs filhos de mães com DMG e de mães com TNG quanto ao peso ao nascer, porém observou-se, respectivamente, diferença significativa na porcentagem de gordura corporal (10,9 x 9 por cento , p=0,004), massa de gordura corporal (0,36 x 0,3kg, p=0,016), porcentagem de massa livre de gordura (89,2 x 91 por cento , p=0,01) e circunferência abdominal (32,8 x 31,2cm, p<0,001). Em relação às mães, detectou-se diferença estatisticamente significativa, respectivamente, quanto à idade da mãe (29 x 25,9 anos, p=0,001), porcentagem de gordura corporal (36,9 x 32,1 por cento , p<0,001), massa de gordura corporal (33,6 x 24,0 kg, p<0,001), massa livre de gordura (53,6 x 48,3, p<0,001), todas as composições segmentares de massa gorda e massa livre de gordura (p<0,001), ganho de peso durante a gestação (13,7 x 11,0 kg, p=0,022) e IMC pré-gestacional (30,4 x 25,3 kg/m2, p<0,001). Conclusão RNs de portadoras de DMG, embora possuam peso ao nascer semelhante aos RNs de mães com TNG, apresentam maior adiposidade corporal, e, portanto, um risco aumentado de desenvolverem doenças metabólicas e obesidade em diferentes fases da vida, realimentando o ciclo da epidemia de obesidade mundial.
Introduction - In 2012, the International Diabetes Federation reported that there are more than 371 million people diagnosed with Diabetes Mellitus worldwide. Brazil ranks third due…
Advisors/Committee Members: Rondo, Patricia Helen de Carvalho.
Subjects/Keywords: Body Composition; Composição Corporal; Diabetes; Diabetes Mellitus Gestacional; Gestational; Newborn; Recém-Nascido
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APA ·
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Export
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APA (6th Edition):
Abreu, L. R. S. d. (2014). Composição corporal de recém-nascidos e de mães com diabetes mellitus gestacional e de recém-nascidos e mães com tolerância normal à glicose. (Masters Thesis). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/6/6138/tde-04112014-101809/ ;
Chicago Manual of Style (16th Edition):
Abreu, Laísa Ribeiro Silva de. “Composição corporal de recém-nascidos e de mães com diabetes mellitus gestacional e de recém-nascidos e mães com tolerância normal à glicose.” 2014. Masters Thesis, University of São Paulo. Accessed January 18, 2021.
http://www.teses.usp.br/teses/disponiveis/6/6138/tde-04112014-101809/ ;.
MLA Handbook (7th Edition):
Abreu, Laísa Ribeiro Silva de. “Composição corporal de recém-nascidos e de mães com diabetes mellitus gestacional e de recém-nascidos e mães com tolerância normal à glicose.” 2014. Web. 18 Jan 2021.
Vancouver:
Abreu LRSd. Composição corporal de recém-nascidos e de mães com diabetes mellitus gestacional e de recém-nascidos e mães com tolerância normal à glicose. [Internet] [Masters thesis]. University of São Paulo; 2014. [cited 2021 Jan 18].
Available from: http://www.teses.usp.br/teses/disponiveis/6/6138/tde-04112014-101809/ ;.
Council of Science Editors:
Abreu LRSd. Composição corporal de recém-nascidos e de mães com diabetes mellitus gestacional e de recém-nascidos e mães com tolerância normal à glicose. [Masters Thesis]. University of São Paulo; 2014. Available from: http://www.teses.usp.br/teses/disponiveis/6/6138/tde-04112014-101809/ ;
Universidade do Rio Grande do Sul
19.
Reinheimer, Shaline Modena.
Incidência de iniciação ao aleitamento materno e fatores associados em coorte de mulheres que tiveram diabetes mellitus gestacional.
Degree: 2017, Universidade do Rio Grande do Sul
URL: http://hdl.handle.net/10183/159183
► Diabetes mellitus gestacional (DMG) é uma condição cada vez mais frequente na população, uma vez que os novos critérios adotados consideram menores valores de glicemia…
(more)
▼ Diabetes mellitus gestacional (DMG) é uma condição cada vez mais frequente na população, uma vez que os novos critérios adotados consideram menores valores de glicemia para diagnóstico e cada vez mais mulheres iniciam a gestação com excesso de peso, fator de risco para DMG. Cerca de 50% das mulheres que tiveram DMG irão desenvolver diabetes mellitus tipo 2 (DM2) entre 5 e 10 anos após o parto. Uma das intervenções utilizada para prevenção do DM2 é o aleitamento materno (AM). Entretanto, são escassas as informações sobre AM em mulheres que tiveram DMG. Sendo assim, o objetivo deste estudo é avaliar o aleitamento materno em mulheres que tiveram diabetes gestacional e os fatores associados à não iniciação. Trata-se de um estudo de coorte, com dados da linha de base e seguimento de um estudo maior, LINDA-Brasil, realizado nas cidades de Porto Alegre (RS), Pelotas (RS) e Fortaleza (CE), de março de 2013 a dezembro de 2016. Gestantes com DMG foram arroladas em serviços de pré-natal de alto risco. Foram coletados dados demográficos, sócio-econômicos, de estilo de vida e contato. O seguimento foi realizado por ligações telefônicas e foram coletadas informações do parto, dados do recém-nascido e amamentação. Essas ligações foram realizadas um mês após o recrutamento e dois meses após o parto. A descrição dos dados foi apresentada através de frequências relativas e absolutas ou média e desvio padrão. Análise de Regressão de Poisson foi utilizada para estimar o risco relativo de não ter iniciado aleitamento materno. Todas as participantes assinaram termo de consentimento livre e esclarecido. Foram incluídas 2523 mulheres. A média de idade foi 31,3 (±6,3) anos, sendo a maioria branca (49,5%), com ensino médio completo (38,3%) e renda entre 1 e 2 salários mínimos (39,9%). Não ter amamentado o último bebê (RR = 3,82; IC95%: 1,86 – 7,84), fumo durante a gestação (RR = 2,09; IC95%: 1,17 – 3,75), bebê com problemas ao nascer (RR = 3,11; IC95%: 1,90 – 5,12), prematuridade (RR = 1,60; IC95%: 1,09 – 2,57), consumo de bebidas adoçadas (RR = 1,10; IC95%: 1,02 – 1,19) e não ter intenção de amamentar o bebê (RR = 4,75; IC95%: 1,92 – 11,72) foram relacionadas à não iniciação ao aleitamento materno. Experiências anteriores, problemas com o bebê e comportamento materno, como fumo na gestação, consumo de bebidas adoçadas e não ter intenção de amamentar são fatores associados à não iniciação ao aleitamento materno em mulheres que tiveram diabetes mellitus gestacional.
Gestational diabetes mellitus (GDM) is an increasingly frequent condition in the population, since the new criteria adopted consider lower values of glycemia for diagnosis, and more and more women are starting gestation with excess weight, a risk factor for GDM. About 50% of women who have GDM will develop type 2 diabetes mellitus (DM2) between 5 and 10 years after giving birth. One of the interventions used to prevent DM2 is breastfeeding. However, there is little information on AM in women who have GDM. Therefore, the objective of this study is to evaluate breastfeeding in…
Advisors/Committee Members: Drehmer, Michele.
Subjects/Keywords: Aleitamento materno; Pregnancy; Diabetes gestacional; Gestational diabetes mellitus; Gravidez de alto risco; Breastfeeding
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APA (6th Edition):
Reinheimer, S. M. (2017). Incidência de iniciação ao aleitamento materno e fatores associados em coorte de mulheres que tiveram diabetes mellitus gestacional. (Thesis). Universidade do Rio Grande do Sul. Retrieved from http://hdl.handle.net/10183/159183
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Reinheimer, Shaline Modena. “Incidência de iniciação ao aleitamento materno e fatores associados em coorte de mulheres que tiveram diabetes mellitus gestacional.” 2017. Thesis, Universidade do Rio Grande do Sul. Accessed January 18, 2021.
http://hdl.handle.net/10183/159183.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Reinheimer, Shaline Modena. “Incidência de iniciação ao aleitamento materno e fatores associados em coorte de mulheres que tiveram diabetes mellitus gestacional.” 2017. Web. 18 Jan 2021.
Vancouver:
Reinheimer SM. Incidência de iniciação ao aleitamento materno e fatores associados em coorte de mulheres que tiveram diabetes mellitus gestacional. [Internet] [Thesis]. Universidade do Rio Grande do Sul; 2017. [cited 2021 Jan 18].
Available from: http://hdl.handle.net/10183/159183.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Reinheimer SM. Incidência de iniciação ao aleitamento materno e fatores associados em coorte de mulheres que tiveram diabetes mellitus gestacional. [Thesis]. Universidade do Rio Grande do Sul; 2017. Available from: http://hdl.handle.net/10183/159183
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Gothenburg / Göteborgs Universitet
20.
Svensson, Henrik.
Human adipose tissue morphology and function : relation to insulin sensitivity and glucose tolerance with focus on pregnancy and women with previous gestational diabetes mellitus.
Degree: 2015, University of Gothenburg / Göteborgs Universitet
URL: http://hdl.handle.net/2077/39574
► Obesity is a global health problem and affects women of reproductive age. During pregnancy, obesity increases the risk for gestational diabetes mellitus (GDM), in turn…
(more)
▼ Obesity is a global health problem and affects women of reproductive age. During pregnancy, obesity increases the risk for gestational diabetes mellitus (GDM), in turn predisposing for type 2 diabetes (T2D). Not only the amount and distribution of adipose tissue (AT) but also the AT morphology and function are of importance in pathogenesis of metabolic disease related to obesity. The aims of this thesis were 1) to compare subcutaneous (SC) and visceral AT regarding release of adipokines, implicated in insulin resistance/inflammation, using an in vitro system reflecting the release in vivo, and 2) to characterize AT morphology and function in normal weight (NW) and obese pregnant women in trimester 1 and 3, and in women with previous GDM, and identify AT-related factors associated with insulin resistance and impaired glucose metabolism.
AT biopsies were obtained from 1) patients undergoing surgery at Sahlgrenska University Hospital, and 2) women in the Pregnancy Obesity Nutrition and Child Health (PONCH) study. AT adipokine release and immune cell/blood vessel density, and adipocyte size/number and lipolytic activity were analyzed. Women were examined regarding insulin resistance (HOMA-IR), glucose tolerance, body composition and blood chemistry.
Chemerin, cytokines, and dipeptidyl peptidase 4 were more abundantly released from visceral than SC AT; adiponectin release was higher from the SC depot. During pregnancy, NW women accumulated fat in existing adipocytes (which became larger) and adiponectin levels were reduced. Obese women had signs of adipocyte recruitment and maintained adiponectin levels. Fat mass and the proportion of very large adipocytes were associated with HOMA-IR in trimester 3. In women with previous GDM, follow-up body mass index (BMI) was the best discriminator of normal vs impaired glucose metabolism, and waist-to-height ratio and adipocyte volume were associated with HOMA-IR.
To conclude, adipokines implicated in metabolic dysfunction are released from AT in a depot-dependent manner. AT mass/morphology contribute to gestational insulin resistance. During pregnancy, AT morphology appears to change oppositely in NW and obese women, possibly protecting obese women against even more severe insulin resistance. To prevent T2D, BMI and abdominal fat accumulation should be controlled in women after GDM.
Subjects/Keywords: Adipose tissue; Adipocyte; Adipokines; Insulin resistance; Pregnancy; Gestational diabetes mellitus; Type 2 diabetes
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APA (6th Edition):
Svensson, H. (2015). Human adipose tissue morphology and function : relation to insulin sensitivity and glucose tolerance with focus on pregnancy and women with previous gestational diabetes mellitus. (Thesis). University of Gothenburg / Göteborgs Universitet. Retrieved from http://hdl.handle.net/2077/39574
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Svensson, Henrik. “Human adipose tissue morphology and function : relation to insulin sensitivity and glucose tolerance with focus on pregnancy and women with previous gestational diabetes mellitus.” 2015. Thesis, University of Gothenburg / Göteborgs Universitet. Accessed January 18, 2021.
http://hdl.handle.net/2077/39574.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Svensson, Henrik. “Human adipose tissue morphology and function : relation to insulin sensitivity and glucose tolerance with focus on pregnancy and women with previous gestational diabetes mellitus.” 2015. Web. 18 Jan 2021.
Vancouver:
Svensson H. Human adipose tissue morphology and function : relation to insulin sensitivity and glucose tolerance with focus on pregnancy and women with previous gestational diabetes mellitus. [Internet] [Thesis]. University of Gothenburg / Göteborgs Universitet; 2015. [cited 2021 Jan 18].
Available from: http://hdl.handle.net/2077/39574.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Svensson H. Human adipose tissue morphology and function : relation to insulin sensitivity and glucose tolerance with focus on pregnancy and women with previous gestational diabetes mellitus. [Thesis]. University of Gothenburg / Göteborgs Universitet; 2015. Available from: http://hdl.handle.net/2077/39574
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Sydney
21.
Rudland, Victoria Louise.
HETEROGENEITY OF GESTATIONAL DIABETES MELLITUS
.
Degree: 2016, University of Sydney
URL: http://hdl.handle.net/2123/15872
► Gestational diabetes mellitus (GDM) is a complex, heterogeneous disorder. As the prevalence of GDM increases, it is increasingly important to identify subgroups of women within…
(more)
▼ Gestational diabetes mellitus (GDM) is a complex, heterogeneous disorder. As the prevalence of GDM increases, it is increasingly important to identify subgroups of women within the GDM umbrella whose pathophysiology and associated pregnancy risk necessitates a different management approach in order to optimise maternal and neonatal outcomes. Glucokinase maturity-onset diabetes of the young (GCK-MODY) and islet autoimmunity are two such clinical entities. Recently, new pregnancy-specific screening criteria (NSC) for GCK-MODY were proposed to identify women with GDM who warrant GCK genetic testing. We tested the NSC and HbA1c in a multiethnic GDM cohort. The prevalence of GCK-MODY in women with GDM was ~1%. The NSC performed well for Anglo-Celtic women, but less well for women from other ethnic backgrounds. Antepartum HbA1c was not higher in those with GCK-MODY. We report the first two cases of antepartum fetal GCK genotyping and demonstrate how knowledge of fetal GCK genotype guides the management of maternal hyperglycaemia. We examined the prevalence, clinical significance and antepartum to post-partum trajectory of glutamic acid decarboxylase autoantibodies (GADA), insulinoma-associated antigen-2 autoantibodies (IA-2A), insulin autoantibodies (IAA) and zinc transporter 8 autoantibodies (ZnT8A) in a multiethnic GDM cohort. 9.9% of women were positive for one islet autoantibody antepartum. No participant had multiple islet autoantibodies. ZnT8A were the most common islet autoantibody. For women with positive GADA, IA-2A or IAA antepartum, islet autoantibody positivity typically persisted post-partum and 20% of women had post-partum glucose levels consistent with diabetes. In contrast, women with positive ZnT8A antepartum typically demonstrated normal ZnT8A titres post-partum and normal post-partum glucose tolerance. ZnT8A may be a marker for islet autoimmunity in a proportion of women with GDM, but the clinical relevance of ZnT8A in GDM needs further research.
Subjects/Keywords: gestational diabetes mellitus;
glucokinase;
maturity-onset diabetes of the young;
islet auto-antibodies;
autoimmunity;
heterogeniety
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APA (6th Edition):
Rudland, V. L. (2016). HETEROGENEITY OF GESTATIONAL DIABETES MELLITUS
. (Thesis). University of Sydney. Retrieved from http://hdl.handle.net/2123/15872
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Rudland, Victoria Louise. “HETEROGENEITY OF GESTATIONAL DIABETES MELLITUS
.” 2016. Thesis, University of Sydney. Accessed January 18, 2021.
http://hdl.handle.net/2123/15872.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Rudland, Victoria Louise. “HETEROGENEITY OF GESTATIONAL DIABETES MELLITUS
.” 2016. Web. 18 Jan 2021.
Vancouver:
Rudland VL. HETEROGENEITY OF GESTATIONAL DIABETES MELLITUS
. [Internet] [Thesis]. University of Sydney; 2016. [cited 2021 Jan 18].
Available from: http://hdl.handle.net/2123/15872.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Rudland VL. HETEROGENEITY OF GESTATIONAL DIABETES MELLITUS
. [Thesis]. University of Sydney; 2016. Available from: http://hdl.handle.net/2123/15872
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Universitat Autònoma de Barcelona
22.
Monroy Rodríguez, Gabriela.
Diabetes gestacional: influencia de la lactancia en el metabolismo hidrocarbonado.
Degree: Departament de Medicina, 2017, Universitat Autònoma de Barcelona
URL: http://hdl.handle.net/10803/458699
► Breastfeeding has been shown to reduce the risk of developing type 2 diabetes without the mechanisms involved being clearly understood. Glucose profiles in normotolerant women,…
(more)
▼ Breastfeeding has been shown to reduce the risk of developing type 2
diabetes without the mechanisms involved being clearly understood. Glucose profiles in normotolerant women, measured by continuous glucose monitoring (CGM), have not shown significant fluctuations during breastfeeding episodes even in those with
gestational diabetes mellitus (GDM) history. Several studies have proven that smoking influences glycemic values and active smoker women could show this effect during lactancy. The objective of the present study was to analyze the influence of GDM, breastfeeding and smoking on the postpartum glucometric parameters by CGM. METHODS: A prospective observational study was carried out evaluating the glucose levels during the postpartum of normotolerant women with and without previous GDM. Mean glucose values and glycemic variability parameters were assessed by multiple linear regression analysis. History of GDM, breastfeeding, smoking, pregestational body mass index (BMI),
gestational age, postpartum interval and maternal age were included as independent variables. UNIANOVA test was used to estimate the effect of the three main variables. The accute effect of suckling on postprandial and fasting glucose levels was analyzed. Results: CGM was performed in 44 women, 22 with previous GDM and 26 with predominant breastfeeding. Smoking was the only independent variable for mean glucose (β = 0.415 p = 0.005). Breastfeeding and smoking were independent variables for glycemic variability. The estimated difference by GDM was ≈ 0.194 mmol / L (3,495 mg / dL) (p = 0.205); breastfeeding ≈ -0.158 mmol/L (-2.857 mg/dL)(p = .032), and ≈0.411 mmol / L (7.409 mg / dL) (p = 0.049) for smoking. In fed-state, suckling reduced glucose levels between 61 and 85 min, with the highest effect observed at 71-75 min (-12.23 mg, p = 0.024). In fasting 150-min intervals, there were no differences in glucose levels between those episodes affected or not by suckling (-0.262 mg / dL ± 1.22 SE p = 0.831). Conclusions: Women with or without previous GDM did not differ in terms of mean glucose levels and glycemic variability. Women who breastfeed their infants do not present significant differences in their glucose levels compared with artificially feeding women. In breastfeeding women, postprandial episodes show a decrease in glucose concentration from ≈85 min after the commencement of suckling. No significant changes are observed in fasting state. Active smoking women have higher glucose levels. In terms of glycemic variability, of the three factors studied, the greatest differences are observed for smoking.
Advisors/Committee Members: [email protected] (authoremail), true (authoremailshow), Corcoy i Pla, Rosa (director), Leiva Hidalgo, Alberto de (tutor), true (authorsendemail).
Subjects/Keywords: Diabetis mellitus gestacional; Dabetes mellitus gestacional; Gestational diabetes mellitus; Lactància; Lactancia; Breast feeding; Tabaquisme; Tabaquismo; Smoking; Ciències de la Salut; 61
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APA (6th Edition):
Monroy Rodríguez, G. (2017). Diabetes gestacional: influencia de la lactancia en el metabolismo hidrocarbonado. (Thesis). Universitat Autònoma de Barcelona. Retrieved from http://hdl.handle.net/10803/458699
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Monroy Rodríguez, Gabriela. “Diabetes gestacional: influencia de la lactancia en el metabolismo hidrocarbonado.” 2017. Thesis, Universitat Autònoma de Barcelona. Accessed January 18, 2021.
http://hdl.handle.net/10803/458699.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Monroy Rodríguez, Gabriela. “Diabetes gestacional: influencia de la lactancia en el metabolismo hidrocarbonado.” 2017. Web. 18 Jan 2021.
Vancouver:
Monroy Rodríguez G. Diabetes gestacional: influencia de la lactancia en el metabolismo hidrocarbonado. [Internet] [Thesis]. Universitat Autònoma de Barcelona; 2017. [cited 2021 Jan 18].
Available from: http://hdl.handle.net/10803/458699.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Monroy Rodríguez G. Diabetes gestacional: influencia de la lactancia en el metabolismo hidrocarbonado. [Thesis]. Universitat Autònoma de Barcelona; 2017. Available from: http://hdl.handle.net/10803/458699
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
23.
Cezar, Nathália Joanne Bispo.
Participação de Genes Relacionados ao Processo Inflamatório no Diabetes Mellitus Gestacional.
Degree: Mestrado, Genética, 2013, University of São Paulo
URL: http://www.teses.usp.br/teses/disponiveis/17/17135/tde-13062013-085547/
;
► O diabetes mellitus gestacional (DMG) é o distúrbio metabólico mais comum da gravidez. A definição padrão do DMG consiste no metabolismo anormal da glicose diagnosticado…
(more)
▼ O diabetes mellitus gestacional (DMG) é o distúrbio metabólico mais comum da gravidez. A definição padrão do DMG consiste no metabolismo anormal da glicose diagnosticado pela primeira vez durante a gestação. Mulheres que têm história de DMG geralmente apresentam diabetes pós-parto, resistência à insulina, síndrome metabólica, hipertensão e dislipidemia. A detecção precoce deste estado metabólico anormal é importante para eventual intervenção na tentativa de impedir ou mesmo retardar o aparecimento dos outros tipos de diabetes. Alguns estudos têm apontado, em mulheres com DMG, indução de genes envolvidos com resposta imune, particularmente aqueles associados com inflamação. A identificação de genes de inflamação induzidos em gestantes com DMG tem fornecido a base para elucidar a ligação entre vias inflamatórias e DMG. Para testar esta hipótese foi realizada a comparação do perfil transcricional de células mononucleares de sangue periférico (PBMCs) de pacientes com DMG e controles. As amostras de RNA total foram hibridadas utilizando oligo microarrays Agilent ® 4 x 44 K englobando o genoma funcional humano total. Os mRNAs diferencialmente expressos foram identificados aplicando-se a análise de Rank Products, e posteriormente submetidos ao agrupamento hierárquico de Pearson por meio do software Cluster. Utilizando o programa TreeView, foi realizada a construção dos dendrogramas com as representações espaciais dos mRNAs, classificados de acordo com suas funções moleculares e vias biológicas. A partir do banco de dados DAVID, foram identificados 130 processos biológicos significantes (P<0.05) incluindo os de resposta imune e defesa, resposta inflamatória, regulação de citocinas, apoptose, desenvolvimento de vasos sanguíneos e proliferação celular. Entre as vias de maior relevância destacamos a via de interação entre receptores de citocinas e a de sinalização do receptor NOD-like, além das vias de câncer, lúpus e asma. Adicionalmente, encontramos os transcritos dos genes IGFBP2, TCF3, OLR1, TCF7L2, previamente associados a alterações metabólicas, diferencialmente expressos nas gestantes com DMG. Também observamos que genes do complexo principal de histocompatibilidade (MHC), HLA-DRB6, HLA-DQA2, HLA-DQB2, HLA-DQB1, HLA-DOA, apresentaram mRNAs induzidos nas pacientes com DMG. A partir deste estudo, constatamos que vias relacionadas ao sistema imunológico e categorias funcionais associadas à inflamação participam da patogenia do DMG. Além disso, evidenciamos que transcritos de genes que pertencem ao MHC e aqueles envolvidos em processos metabólicos, estiveram diferencialmente expressos no DMG. Estes resultados confirmam nossa hipótese inicial e contribuem para o melhor entendimento das bases genéticas desta doença.
Gestational Diabetes Mellitus (GDM) is the most common metabolic disorder found during pregnancy. The standard definition of GDM is the abnormal glucose metabolism first diagnosed during pregnancy. Women who have a history of GDM usually present postpartum diabetes, insulin resistance, metabolic syndrome,…
Advisors/Committee Members: Passos Junior, Geraldo Aleixo da Silva.
Subjects/Keywords: Microarrays; Diabetes mellitus gestacional; Expressão gênica; Gene expression; Genes de inflamação; Gestational diabetes mellitus; Inflammation genes; Microarrays
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APA ·
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APA (6th Edition):
Cezar, N. J. B. (2013). Participação de Genes Relacionados ao Processo Inflamatório no Diabetes Mellitus Gestacional. (Masters Thesis). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/17/17135/tde-13062013-085547/ ;
Chicago Manual of Style (16th Edition):
Cezar, Nathália Joanne Bispo. “Participação de Genes Relacionados ao Processo Inflamatório no Diabetes Mellitus Gestacional.” 2013. Masters Thesis, University of São Paulo. Accessed January 18, 2021.
http://www.teses.usp.br/teses/disponiveis/17/17135/tde-13062013-085547/ ;.
MLA Handbook (7th Edition):
Cezar, Nathália Joanne Bispo. “Participação de Genes Relacionados ao Processo Inflamatório no Diabetes Mellitus Gestacional.” 2013. Web. 18 Jan 2021.
Vancouver:
Cezar NJB. Participação de Genes Relacionados ao Processo Inflamatório no Diabetes Mellitus Gestacional. [Internet] [Masters thesis]. University of São Paulo; 2013. [cited 2021 Jan 18].
Available from: http://www.teses.usp.br/teses/disponiveis/17/17135/tde-13062013-085547/ ;.
Council of Science Editors:
Cezar NJB. Participação de Genes Relacionados ao Processo Inflamatório no Diabetes Mellitus Gestacional. [Masters Thesis]. University of São Paulo; 2013. Available from: http://www.teses.usp.br/teses/disponiveis/17/17135/tde-13062013-085547/ ;
24.
Carvalho, Teresa Maria de Jesus Ponte.
Influência do diabetes mellitus gestacional na disposição cinética e metabolismo estereosseletivos do labetalol em pacientes com hipertensão arterial.
Degree: PhD, Toxicologia, 2009, University of São Paulo
URL: http://www.teses.usp.br/teses/disponiveis/60/60134/tde-13072009-151617/
;
► O labetalol, um anti-hipertensivo considerado seguro para uso em gestantes, está disponível na clínica como mistura de dois racematos (quatro estereoisômeros), sendo o isômero (R,R)…
(more)
▼ O labetalol, um anti-hipertensivo considerado seguro para uso em gestantes, está disponível na clínica como mistura de dois racematos (quatro estereoisômeros), sendo o isômero (R,R) antagonista e o (S,R) responsável pela atividade bloqueadora. O estudo investiga a influência do diabetes mellitus gestacional (DMG) na disposição cinética e no metabolismo estereosseletivos do labetalol administrado por via endovenosa ou oral. Foram investigadas 30 gestantes hipertensas distribuídas em 04 grupos: não diabéticas tratadas com dose única de 40 mg de cloridrato de labetalol endovenoso (grupo EVH, n=8) ou 100 mg de cloridrato de labetalol via oral (grupo VOH, n=9) e diabéticas tratadas com 40 mg de cloridrato de labetalol endovenoso (grupo EVD, n=6) ou 100 mg de cloridrato de labetalol via oral (grupo VOD, n=7). As amostras seriadas de sangue foram coletadas até 12 h (via oral) ou 15 h (via endovenosa) após a administração do cloridrato de labetalol. Os estereoisômeros do labetalol em plasma foram analisados em coluna de fase quiral Chirobiotic V empregando LC-MS-MS. Os parâmetros farmacocinéticos do labetalol inalterado e labetalol glicuronídeo foram calculados com auxílio do programa WinNonlin e avaliados empregando os testes de Mann-Whitney e Friedman com pós-teste de Dunn (p<0,05). A farmacocinética do labetalol não é estereosseletiva em gestantes diabéticas e não diabéticas tratadas com o fármaco por via endovenosa. No entanto, a administração oral de labetalol resulta em menores valores de área sob a curva concentração plasmática versus tempo (AUC) para o isômero ativo (R,R)-labetalol tanto em gestantes diabéticas (60,9 vs 162,7 vs 157,9 vs 114,6 ng.h/mL, respectivamente para (R,R,); (SR); (S,S,) e (R,S)) quanto não diabéticas (45,6 vs 84,2 vs 89,4 vs 78,3 ng.h/mL, respectivamente para (R,R,); (SR); (S,S,) e (R,S)). O DMG resulta em alterações na disposição cinética dos estereoisômeros do labetalol na administração oral. Os valores de AUC do isômero inativo (S,S)-labetalol (157,9 vs 89,4 ng.h/mL) e para o isômero -bloqueador (S,R)-labetalol (162.7 vs 84.2 ng.h/mL) são maiores (p<0,05) nas gestantes diabéticas do que nas gestantes não diabéticas. As gestantes diabéticas também mostram maior biodisponibilidade oral do isômero (S,R)-labetalol (54,7 vs 24,0 %) explicada pela reduzida eliminação pré-sistêmica conseqüente da menor capacidade de conjugação com o ácido glicurônico (68,4 vs 77,9 %). Os valores de AUC do isômero (S,R) aproximadamente 100 % maiores nas gestantess diabéticas tratadas com o fármaco por via oral (162,7 vs 84,2 ng.h/mL) pode ter relevância clínica considerando a atividade -bloqueadora do referido isômero.
Labetalol, a hypertensive agent considered to be safe for use by pregnant women, is clinically available as a mixture of two racemates, with the (R,R) isomer being a antagonist and the (S,R) isomer being responsible for the blocking activity. The study investigated the influence of gestational diabetes mellitus (GDM) on the kinetic disposition and stereoselective metabolism of labetalol…
Advisors/Committee Members: Lanchote, Vera Lucia.
Subjects/Keywords: diabetes mellitus gestacional; estereoisômeros; farmacocinética; gestational diabetes mellitus; gravidez; hipertensão arterial; hypertension; labetalol; labetalol; metabolismo; pharmacokinetics; pregnancy; stereoisomers
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APA (6th Edition):
Carvalho, T. M. d. J. P. (2009). Influência do diabetes mellitus gestacional na disposição cinética e metabolismo estereosseletivos do labetalol em pacientes com hipertensão arterial. (Doctoral Dissertation). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/60/60134/tde-13072009-151617/ ;
Chicago Manual of Style (16th Edition):
Carvalho, Teresa Maria de Jesus Ponte. “Influência do diabetes mellitus gestacional na disposição cinética e metabolismo estereosseletivos do labetalol em pacientes com hipertensão arterial.” 2009. Doctoral Dissertation, University of São Paulo. Accessed January 18, 2021.
http://www.teses.usp.br/teses/disponiveis/60/60134/tde-13072009-151617/ ;.
MLA Handbook (7th Edition):
Carvalho, Teresa Maria de Jesus Ponte. “Influência do diabetes mellitus gestacional na disposição cinética e metabolismo estereosseletivos do labetalol em pacientes com hipertensão arterial.” 2009. Web. 18 Jan 2021.
Vancouver:
Carvalho TMdJP. Influência do diabetes mellitus gestacional na disposição cinética e metabolismo estereosseletivos do labetalol em pacientes com hipertensão arterial. [Internet] [Doctoral dissertation]. University of São Paulo; 2009. [cited 2021 Jan 18].
Available from: http://www.teses.usp.br/teses/disponiveis/60/60134/tde-13072009-151617/ ;.
Council of Science Editors:
Carvalho TMdJP. Influência do diabetes mellitus gestacional na disposição cinética e metabolismo estereosseletivos do labetalol em pacientes com hipertensão arterial. [Doctoral Dissertation]. University of São Paulo; 2009. Available from: http://www.teses.usp.br/teses/disponiveis/60/60134/tde-13072009-151617/ ;
25.
Antunes, Natalicia de Jesus.
Influência do Diabetes mellitus gestacional na disposição cinética e no metabolismo enantiosseletivos do metoprolol em parturientes hipertensas.
Degree: Mestrado, Toxicologia, 2010, University of São Paulo
URL: http://www.teses.usp.br/teses/disponiveis/60/60134/tde-03112010-222228/
;
► O metoprolol, um fármaco aceito no tratamento da hipertensão durante a gestação, está disponível na clínica como mistura racêmica dos enantiômeros S-(-) e R-(+), embora…
(more)
▼ O metoprolol, um fármaco aceito no tratamento da hipertensão durante a gestação, está disponível na clínica como mistura racêmica dos enantiômeros S-(-) e R-(+), embora o S-(-)-metoprolol seja considerado o eutômero em termos do bloqueio do receptor 1 adrenérgico. O presente estudo avalia a influência do
Diabetes mellitus gestacional na disposição cinética e no metabolismo enantiosseletivos do metoprolol em parturientes hipertensas. As parturientes hipertensas investigadas (n=35) com idade gestacional de 35-42 semanas e fenotipadas como metabolizadoras extensivas tipo metoprolol, foram distribuídas nos grupos controle (n=24) ou portadoras de
Diabetes mellitus gestacional (n=11). As parturientes foram tratadas com dose única oral de 100 mg de tartarato de metoprolol racêmico 1-11 h antes do parto. Foram coletadas amostras seriadas de sangue materno (0-24h) e no momento do parto foram coletados simultaneamente sangue materno, sangue do cordão umbilical e líquido amniótico. Os enantiômeros do metoprolol e seus metabólitos foram quantificados por LC-MS/MS ou por detecção por fluorescência. A disposição cinética do metoprolol é enantiosseletiva em parturientes hipertensas com observação de maiores concentrações plasmáticas (AUC0- 113,42 vs 62,65 ng.h/mL) e menor clearance total aparente (344,21 vs 623,14 L/h) para o eutômero S-(-)-metoprolol. A formação do metabólito -hidroximetoprolol também é estereosseletiva com favorecimento do novo centro quiral 1R (AUC0- 1R/1S=2,84). O favorecimento da formação do R-(+)-ácido O-desmetilmetoprolóico (AUC0- 2,77 vs 2,66 g.h/mL) explica o acúmulo plasmático do S-(-)-metoprolol. O
Diabetes mellitus gestacional compensado prolonga o tmax para ambos os enantiômeros do metoprolol (1,5 vs 2,5 h) e ácido O-desmetilmetoprolóico (2,0 vs 3,5 h) e para todos os isômeros do -hidroximetoprolol (2,0 vs 3,0 h). O
Diabetes mellitus gestacional compensado não altera as razões isoméricas de concentrações plasmáticas do metoprolol, -hidroximetoprolol e ácido O-desmetilmetoprolóico. As razões de concentrações líquido amniótico/plasma materno obtidas para ambos os enantiômeros do metoprolol (3,0 para o R-(+)-metoprolol e 3,2 para o S-(-)-metoprolol) e para os isômeros do -hidroximetoprolol (5,1 para o 1\'S,2R; 4,0 para o 1\'S,2S; 1,6 para o 1\'R,2R e 2,3 para o 1\'R,2S) evidenciam maiores concentrações dos fármacos no líquido amniótico do que no plasma materno. No entanto, os enantiômeros do ácido O-desmetilmetoprolóico atingem menores concentrações no líquido amniótico do que no plasma materno das parturientes hipertensas (líquido amniótico/plasma materno = 0,29 e 0,37 respectivamente para os enantiômeros R-(+)- e S-(-)). A distribuição transplacentária é próxima a 1 para ambos os enantiômeros do metoprolol e para todos os isômeros do -hidroximetoprolol e próxima a 0,8 para ambos os enantiômeros do ácido O-desmetilmetoprolóico em parturientes hipertensas. O
Diabetes mellitus gestacional compensado reduz em aproximadamente 20% a distribuição transplacentária dos isômeros 1S,2S; 1R,2R; e…
Advisors/Committee Members: Lanchote, Vera Lucia.
Subjects/Keywords: Diabetes mellitus gestacional; enantiômeros; enantiomers; farmacocinética; gestational Diabetes mellitus; hipertensão arterial; hypertension; metoprolol; metoprolol; parturient; parturientes; pharmacokinetics
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APA ·
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APA (6th Edition):
Antunes, N. d. J. (2010). Influência do Diabetes mellitus gestacional na disposição cinética e no metabolismo enantiosseletivos do metoprolol em parturientes hipertensas. (Masters Thesis). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/60/60134/tde-03112010-222228/ ;
Chicago Manual of Style (16th Edition):
Antunes, Natalicia de Jesus. “Influência do Diabetes mellitus gestacional na disposição cinética e no metabolismo enantiosseletivos do metoprolol em parturientes hipertensas.” 2010. Masters Thesis, University of São Paulo. Accessed January 18, 2021.
http://www.teses.usp.br/teses/disponiveis/60/60134/tde-03112010-222228/ ;.
MLA Handbook (7th Edition):
Antunes, Natalicia de Jesus. “Influência do Diabetes mellitus gestacional na disposição cinética e no metabolismo enantiosseletivos do metoprolol em parturientes hipertensas.” 2010. Web. 18 Jan 2021.
Vancouver:
Antunes NdJ. Influência do Diabetes mellitus gestacional na disposição cinética e no metabolismo enantiosseletivos do metoprolol em parturientes hipertensas. [Internet] [Masters thesis]. University of São Paulo; 2010. [cited 2021 Jan 18].
Available from: http://www.teses.usp.br/teses/disponiveis/60/60134/tde-03112010-222228/ ;.
Council of Science Editors:
Antunes NdJ. Influência do Diabetes mellitus gestacional na disposição cinética e no metabolismo enantiosseletivos do metoprolol em parturientes hipertensas. [Masters Thesis]. University of São Paulo; 2010. Available from: http://www.teses.usp.br/teses/disponiveis/60/60134/tde-03112010-222228/ ;
26.
Langstaff, Samantha.
Bringing an Evidence-Based Nutrition and Exercise Lifestyle Intervention Program (NELIP) for Obese Pregnant Women into Clinical Practice.
Degree: 2015, University of Western Ontario
URL: https://ir.lib.uwo.ca/etd/3290
► One purpose was to identify the need for specialized care (My Clinic) for women with a pre-pregnancy body mass index (BMI) of ≥ 35 kg/m2..…
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▼ One purpose was to identify the need for specialized care (My Clinic) for women with a pre-pregnancy body mass index (BMI) of ≥ 35 kg/m2.. Women receiving My Clinic care were compared to a matched cohort control group (perinatal database, N=47). My Clinic care significantly reduced rates of macrosomia (5% vs 28%, p=0.02) and small birth weight babies (0% vs 6%, p=0.00) compared to perinatal database.
The second purpose was to test the efficacy of a Nutrition and Exercise Lifestyle Intervention Program (NELIP) in this clinical setting to prevent excessive weight gain, macrosmia, small birth weight babies and pregnancy complications. Twelve women with a BMI ≥ 35 kg/m2 were randomized between 12-20 weeks of pregnancy to Nutrition-only, Exercise-only, or full NELIP. Exercise-only intervention reduced rate of weight gain (0.15 ± 0.13 kg/week vs 0.61 ± 0.12 kg/week, p=0.01) compared to Nutrition-only. Combining a nutrition and exercise intervention appeared difficult for this population, as 100% of the women randomized to full NELIP did not complete the program.
Subjects/Keywords: Obesity; gestational weight gain; exercise and pregnancy; nutrition and pregnancy; gestational diabetes mellitus; macrosomia; Obstetrics and Gynecology
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APA ·
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APA (6th Edition):
Langstaff, S. (2015). Bringing an Evidence-Based Nutrition and Exercise Lifestyle Intervention Program (NELIP) for Obese Pregnant Women into Clinical Practice. (Thesis). University of Western Ontario. Retrieved from https://ir.lib.uwo.ca/etd/3290
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Langstaff, Samantha. “Bringing an Evidence-Based Nutrition and Exercise Lifestyle Intervention Program (NELIP) for Obese Pregnant Women into Clinical Practice.” 2015. Thesis, University of Western Ontario. Accessed January 18, 2021.
https://ir.lib.uwo.ca/etd/3290.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Langstaff, Samantha. “Bringing an Evidence-Based Nutrition and Exercise Lifestyle Intervention Program (NELIP) for Obese Pregnant Women into Clinical Practice.” 2015. Web. 18 Jan 2021.
Vancouver:
Langstaff S. Bringing an Evidence-Based Nutrition and Exercise Lifestyle Intervention Program (NELIP) for Obese Pregnant Women into Clinical Practice. [Internet] [Thesis]. University of Western Ontario; 2015. [cited 2021 Jan 18].
Available from: https://ir.lib.uwo.ca/etd/3290.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Langstaff S. Bringing an Evidence-Based Nutrition and Exercise Lifestyle Intervention Program (NELIP) for Obese Pregnant Women into Clinical Practice. [Thesis]. University of Western Ontario; 2015. Available from: https://ir.lib.uwo.ca/etd/3290
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
27.
Evangelista, Adriane Feijó.
Análise Integrativa de Perfis Transcricionais de Pacientes com Diabetes Mellitus Tipo 1, Tipo 2 e Gestacional, Comparando-os com Manifestações Demográficas, Clínicas, Laboratoriais, Fisiopatológicas e Terapêuticas.
Degree: PhD, Genética, 2012, University of São Paulo
URL: http://www.teses.usp.br/teses/disponiveis/17/17135/tde-14062012-124439/
;
► O diabetes mellitus tipo 1 (DM1) tem etiologia autoimune, enquanto o diabetes mellitus tipo 2 (DM2) e o diabetes mellitus gestacional (DMG) são considerados como…
(more)
▼ O diabetes mellitus tipo 1 (DM1) tem etiologia autoimune, enquanto o diabetes mellitus tipo 2 (DM2) e o diabetes mellitus gestacional (DMG) são considerados como distúrbios metabólicos. Neste trabalho, foi realizada análise do transcriptoma das células mononucleares do sangue periférico (do inglês, peripheral mononuclear blood cells - PBMCs), obtidas de pacientes com DM1, DM2 e DMG, realizando análises por module maps a fim de comparar características patogênicas e aspectos gerais do tratamento com anotações disponíveis de genes modulados, tais como: a) análises disponíveis a partir de estudos de associação em larga escala (do inglês genome-wide association studies GWAS); b) genes associados ao diabetes em estudos clássicos de ligação disponíveis em bancos de dados públicos; c) perfis de expressão de células imunológicas fornecidos pelo grupo ImmGen (Immunological Project). Foram feitos microarrays do transcriptoma total da plataforma Agilent (Whole genome onecolor Agilent 4x44k) para 56 pacientes (19 DM1, 20 DM2 e 17 DMG). Para a compreensão dos resultados foram aplicados filtros não-informativos e as listas de genes diferencialmente expressos foram obtidas por análise de partição e análise estatística não-paramétrica (rank products), respectivamente. Posteriormente, análises de enriquecimento funcional foram feitas pelo DAVID e os module maps construídos usando a ferramenta Genomica. As análises funcionais contribuíram para discriminar os pacientes a partir de genes envolvidos na inflamação, em especial DM1 e DMG. Os module maps de genes diferencialmente expressos revelaram: a) genes modulados exibiram perfis de transcrição típicos de macrófagos e células dendríticas, b) genes modulados foram associados com genes previamente descritos como genes de complicação ao diabetes a partir de estudos de ligação e de meta-análises; c) a duração da doença, obesidade, número de gestações, níveis de glicose sérica e uso de medicações, tais como metformina, influenciaram a expressão gênica em pelo menos um tipo de diabetes. Esse é o primeiro estudo de module maps mostrando a influência de padrões epidemiológicos, clínicos, laboratoriais, imunopatogênicos e de tratamento na modulação dos perfis transcricionais em pacientes com os três tipos clássicos de diabetes: DM1, DM2 e DMG.
Type 1 diabetes (T1D) is an autoimmune disease while type 2 (T2D) and gestational diabetes (GDM) are considered as metabolic disturbances. We performed a transcriptome analysis of peripheral mononuclear blood cells obtained from T1D, T2D and GDM patients, and we took advantage of the module map approach to compare pathogenic and treatment features of our patient series with available annotation of modulated genes from i) genome-wide association studies; ii) genes provided by diabetes meta-analysis in public databases, iii) immune cell gene expression profiles provided by the ImmGen project. Whole genome one-color Agilent 4x44k microarray was performed for 56 (19 T1D, 20 T2D, 17 GDM) patients. Noninformative filtered and differentially…
Advisors/Committee Members: Donadi, Eduardo Antonio, Passos Junior, Geraldo Aleixo da Silva.
Subjects/Keywords: Bioinformatic analysis by module maps; Bioinformática; Diabetes mellitus gestacional; Diabetes mellitus tipo 1; Diabetes mellitus tipo 2; Expressão gênica; Gene expression; Gestational diabetes mellitus; Microarrays; Microarrays; Module maps; Type 1 diabetes mellitus; Type 2 diabetes mellitus
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APA (6th Edition):
Evangelista, A. F. (2012). Análise Integrativa de Perfis Transcricionais de Pacientes com Diabetes Mellitus Tipo 1, Tipo 2 e Gestacional, Comparando-os com Manifestações Demográficas, Clínicas, Laboratoriais, Fisiopatológicas e Terapêuticas. (Doctoral Dissertation). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/17/17135/tde-14062012-124439/ ;
Chicago Manual of Style (16th Edition):
Evangelista, Adriane Feijó. “Análise Integrativa de Perfis Transcricionais de Pacientes com Diabetes Mellitus Tipo 1, Tipo 2 e Gestacional, Comparando-os com Manifestações Demográficas, Clínicas, Laboratoriais, Fisiopatológicas e Terapêuticas.” 2012. Doctoral Dissertation, University of São Paulo. Accessed January 18, 2021.
http://www.teses.usp.br/teses/disponiveis/17/17135/tde-14062012-124439/ ;.
MLA Handbook (7th Edition):
Evangelista, Adriane Feijó. “Análise Integrativa de Perfis Transcricionais de Pacientes com Diabetes Mellitus Tipo 1, Tipo 2 e Gestacional, Comparando-os com Manifestações Demográficas, Clínicas, Laboratoriais, Fisiopatológicas e Terapêuticas.” 2012. Web. 18 Jan 2021.
Vancouver:
Evangelista AF. Análise Integrativa de Perfis Transcricionais de Pacientes com Diabetes Mellitus Tipo 1, Tipo 2 e Gestacional, Comparando-os com Manifestações Demográficas, Clínicas, Laboratoriais, Fisiopatológicas e Terapêuticas. [Internet] [Doctoral dissertation]. University of São Paulo; 2012. [cited 2021 Jan 18].
Available from: http://www.teses.usp.br/teses/disponiveis/17/17135/tde-14062012-124439/ ;.
Council of Science Editors:
Evangelista AF. Análise Integrativa de Perfis Transcricionais de Pacientes com Diabetes Mellitus Tipo 1, Tipo 2 e Gestacional, Comparando-os com Manifestações Demográficas, Clínicas, Laboratoriais, Fisiopatológicas e Terapêuticas. [Doctoral Dissertation]. University of São Paulo; 2012. Available from: http://www.teses.usp.br/teses/disponiveis/17/17135/tde-14062012-124439/ ;
28.
Pelá, Flávia Porto.
Associação do polimorfismo INS-VNTR com a susceptibilidade ao diabetes mellitus tipo 1, tipo 2 e gestacional na população urbana brasileira.
Degree: Mestrado, Genética, 2012, University of São Paulo
URL: http://www.teses.usp.br/teses/disponiveis/17/17135/tde-22042013-110542/
;
► O diabetes mellitus (DM) é definido como doença metabólica, caracterizado pela hiperglicemia, causada pela disfunção da secreção de insulina, atividade da insulina ou ambas. É…
(more)
▼ O
diabetes mellitus (DM) é definido como doença metabólica, caracterizado pela hiperglicemia, causada pela disfunção da secreção de insulina, atividade da insulina ou ambas. É classificado em quatro classes clínicas i)
diabetes mellitus tipo 1 (DM1), ii)
diabetes mellitus tipo 2 (DM2), iii)
diabetes mellitus gestacional (DMG), iv) outros tipos específicos. Dentre os genes conhecidos por influenciarem o mecanismo de produção e liberação de insulina no organismo humano, o gene da insulina (INS) é o mais bem caracterizado nas classes clínicas do DM. A região promotora do gene INS tem sido alvo de estudo em diversas amostras populacionais do mundo, devido a sua capacidade de modular os níveis de expressão de insulina no timo e no pâncreas, de acordo, com a classe alélica que compõe o genótipo do indivíduo. Localizada a 596pb acima do sítio de transcrição do gene da insulina, é estruturada em alelos minissatélites distribuídos in tandem (ACAGGGGTGTGGGG). O alelo classe I (30 - 60 repetições) tem sido associado com predisposição ao DM1, enquanto o alelo classe III (120 - 170 repetições) tem efeito de proteção ao DM1, no entanto, esse alelo tem apresentado correlação ao DM2, à obesidade em crianças e jovens e, aumento de riscos cardiovasculares. O presente trabalho tem como objetivo analisar o polimorfismo da região promotora do gene da insulina sobre os fenótipos do DM e a possível influência desse em características demográficas, clínicas e laboratoriais desses pacientes. Foram analisados 189 pacientes com DM1, 116 pacientes com DM2, 68 pacientes com DMG e 339 indivíduos controle da região de Ribeirão Preto, SP. O DNA genômico foi extraído por salting-out, seguido da amplificação e digestão enzimática do fragmento referente a região promotora do gene INS, o qual contém na sequência downstream, o polimorfismo -23HphI, cujo desequilíbrio de ligação (r2 1) com o polimorfismo INSVNTR, permite inferir os genótipos por intermédio da análise do polimorfismo -23HphI. Observamos que o alelo classe I e o genótipo classe I : classe I estão relacionados à predisposição ao DM1, enquanto o alelo classe III, predominantemente em homozigose, está associado à proteção ao DM1. Em relação ao DM2, o genótipo classe I : classe III foi associado à susceptibilidade a doença e, nenhum genótipo foi correlacionado ao DMG. De acordo com os dados demográficos, clínicos e laboratoriais, variáveis como gênero e pigmentação da pele têm influenciado na frequência do polimorfismo INSVNTR em pacientes com DM1, como por exemplo, a maior frequência de homens com genótipo classe I : classe I no conjunto DM1. Em contrapartida, nesse mesmo grupo de pacientes, o genótipo classe III : classe III evidenciou maior susceptibilidade ao desenvolvimento de retinopatia (p=0,0020; OR= 0,05333; 95% I.C. 0,007839 - 0,3629). Em pacientes com DM2, a comparação entre gêneros evidenciou maior frequência do genótipo classe III : classe III em mulheres. E, em relação ao DMG, os genótipos de classe I : classe I e classe I : classe III estavam…
Advisors/Committee Members: Donadi, Eduardo Antonio.
Subjects/Keywords: -23HphI; -23HphI; INS-VNTR; INS-VNTR; Brazilian population; Diabetes mellitus gestacional; Diabetes mellitus tipo 1; Diabetes mellitus tipo 2; Gestational diabetes mellitus; Insulina; População brasileira; Type 1 diabetes mellitus; Type 2 diabetes mellitus
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APA ·
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MLA ·
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Export
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Manager
APA (6th Edition):
Pelá, F. P. (2012). Associação do polimorfismo INS-VNTR com a susceptibilidade ao diabetes mellitus tipo 1, tipo 2 e gestacional na população urbana brasileira. (Masters Thesis). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/17/17135/tde-22042013-110542/ ;
Chicago Manual of Style (16th Edition):
Pelá, Flávia Porto. “Associação do polimorfismo INS-VNTR com a susceptibilidade ao diabetes mellitus tipo 1, tipo 2 e gestacional na população urbana brasileira.” 2012. Masters Thesis, University of São Paulo. Accessed January 18, 2021.
http://www.teses.usp.br/teses/disponiveis/17/17135/tde-22042013-110542/ ;.
MLA Handbook (7th Edition):
Pelá, Flávia Porto. “Associação do polimorfismo INS-VNTR com a susceptibilidade ao diabetes mellitus tipo 1, tipo 2 e gestacional na população urbana brasileira.” 2012. Web. 18 Jan 2021.
Vancouver:
Pelá FP. Associação do polimorfismo INS-VNTR com a susceptibilidade ao diabetes mellitus tipo 1, tipo 2 e gestacional na população urbana brasileira. [Internet] [Masters thesis]. University of São Paulo; 2012. [cited 2021 Jan 18].
Available from: http://www.teses.usp.br/teses/disponiveis/17/17135/tde-22042013-110542/ ;.
Council of Science Editors:
Pelá FP. Associação do polimorfismo INS-VNTR com a susceptibilidade ao diabetes mellitus tipo 1, tipo 2 e gestacional na população urbana brasileira. [Masters Thesis]. University of São Paulo; 2012. Available from: http://www.teses.usp.br/teses/disponiveis/17/17135/tde-22042013-110542/ ;
Tampere University
29.
Vilmi-Kerälä, Tiina.
Cardiovascular Risk Factors and Arterial Function After Gestational Diabetes Mellitus : Role of obesity and metabolic syndrome
.
Degree: 2018, Tampere University
URL: https://trepo.tuni.fi/handle/10024/104072
► Raskausdiabetes eli gestationaalinen diabetes mellitus (GDM) tarkoittaa poikkeavaa glukoosiaineenvaihduntaa, joka todetaan ensimmäisen kerran raskauden aikana. Vuonna 2016 GDM komplisoi 17,5% raskauksista Suomessa. Yleensä poikkeava glukoosiaineenvaihdunta…
(more)
▼ Raskausdiabetes eli gestationaalinen diabetes mellitus (GDM) tarkoittaa poikkeavaa glukoosiaineenvaihduntaa, joka todetaan ensimmäisen kerran raskauden aikana. Vuonna 2016 GDM komplisoi 17,5% raskauksista Suomessa. Yleensä poikkeava glukoosiaineenvaihdunta normalisoituu synnytyksen jälkeen, mutta raskausdiabeetikoilla on todettu seitsemän kertaa suurempi riski sairastua tyypin 2 diabetekseen (T2DM) myöhemmin elämänsä aikana. Lisäksi raskausdiabeetikoilla on tulevaisuudessa lisääntynyt sydän- ja verisuonitauti- sekä metabolisen oireyhtymän (MBO) riski. Jälkimmäisellä tarkoitetaan valtimotaudin riskitekijöiden kasaumaa. Vaikka MBO on liitetty kohonneeseen sydän- ja verisuonitautiriskiin, sen käyttöä kliinisessä työssä on myös kyseenalaistettu.
Väitöskirjatutkimuksen tavoitteena on ollut selvittää, onko aiemmissa tutkimuksissa osoitettu raskausdiabeteksen jälkeinen kohonnut sydän- ja verisuonitautiriski todettavissa herkillä määrityksillä jo muutama vuosi synnytyksen jälkeen. Lisäksi on pyritty tutkimaan lisääntyvän lihavuuden vaikutuksia tuloksiin. Tutkimuksessa analysoitiin myös MBO-diagnoosin käyttökelpoisuutta kliinisessä työssä arvioitaessa yksilön sydän- ja verisuonitautiriskiä.
Tutkimuksen kahteen, GDM- ja kontrollikohorttiin valittiin yhteensä 240 vuosina 2008–2011 Kanta-Hämeen keskussairaalassa synnyttänyttä naista, joista 120 oli raskausaikana glukoosirasituskokeella diagnosoitu GDM ja 120 todettu normaali sokeriaineenvaihdunta. Osatöissä I–III verrattiin näiden tutkimuskohorttien seurantatutkimusten – haastattelun, fysikaalisten mittausten, laboratorio- ja valtimoiden toimintakokeiden – tuloksia MBO:n esiintyvyyden, sokeri- ja rasva-aineenvaihdunnan, matala-asteisen tulehdustilan sekä valtimoiden elastisuuden suhteen. Arvioitaessa lihavuuden vaikutusta tuloksiin tutkimuspotilaat jaettiin neljään alaryhmään GDM-statuksen sekä painoindeksin mukaan. Yhteensä 27 naisella alkuperäisestä 240 tutkimuspotilaan populaatiosta todettiin MBO. Osatyössä IV verrattiin pareittain näiden 27 MBO:ää sairastavan naisen valtimoiden elastisuustuloksia 27 tunnettujen sydän- ja verisuonitaudin riskitekijöiden suhteen täsmätyn oireyhtymää sairastamattoman naisen vastaaviin tuloksiin.
Osatöissä I–III keskimäärin 3,7 vuotta synnytyksen jälkeen tehdyissä seurantatutkimuksissa todettiin, että raskausdiabeetikoilla esiintyi 2,4-kertaisesti metabolista oireyhtymää verrattuna raskausaikana glukoosiaineenvaihdunnaltaan terveiksi todettuihin naisiin. Myös insuliiniresistenssi oli merkittävästi yleisempää raskausdiabeteksen sairastaneilla naisilla. Matala-asteiseen tulehdusreaktioon viittaava seerumin metalloproteinaasin inhibiittoripitoisuus oli koholla raskausdiabeteksen jälkeen. Lisäksi GDM-ryhmässä naisilla oli suurempi pulssiaallon kulkunopeus viitaten kontrolliryhmän naisia jäykempiin valtimoihin. Suurin osa löydöksistä korostui lihavilla naisilla ylittäen aiemmin sairastetun GDM:n aiheuttaman vaikutuksen. Osatyössä IV tutkittiin metabolista oireyhtymää sairastavien naisten verisuonten elastisuutta. Tuloksia verrattiin tarkasti…
Subjects/Keywords: raskausdiabetes
;
lihavuus
;
metabolinen oireyhtymä
;
pitkäaikaisennuste
;
gestational diabetes mellitus
;
obesity
;
metabolic syndrome
;
long-term outcome
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APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Vilmi-Kerälä, T. (2018). Cardiovascular Risk Factors and Arterial Function After Gestational Diabetes Mellitus : Role of obesity and metabolic syndrome
. (Doctoral Dissertation). Tampere University. Retrieved from https://trepo.tuni.fi/handle/10024/104072
Chicago Manual of Style (16th Edition):
Vilmi-Kerälä, Tiina. “Cardiovascular Risk Factors and Arterial Function After Gestational Diabetes Mellitus : Role of obesity and metabolic syndrome
.” 2018. Doctoral Dissertation, Tampere University. Accessed January 18, 2021.
https://trepo.tuni.fi/handle/10024/104072.
MLA Handbook (7th Edition):
Vilmi-Kerälä, Tiina. “Cardiovascular Risk Factors and Arterial Function After Gestational Diabetes Mellitus : Role of obesity and metabolic syndrome
.” 2018. Web. 18 Jan 2021.
Vancouver:
Vilmi-Kerälä T. Cardiovascular Risk Factors and Arterial Function After Gestational Diabetes Mellitus : Role of obesity and metabolic syndrome
. [Internet] [Doctoral dissertation]. Tampere University; 2018. [cited 2021 Jan 18].
Available from: https://trepo.tuni.fi/handle/10024/104072.
Council of Science Editors:
Vilmi-Kerälä T. Cardiovascular Risk Factors and Arterial Function After Gestational Diabetes Mellitus : Role of obesity and metabolic syndrome
. [Doctoral Dissertation]. Tampere University; 2018. Available from: https://trepo.tuni.fi/handle/10024/104072
University of Alberta
30.
Carson, Glenda A.
Encountering the Other in Nurse-Patient Pedagogic
Relationships: Becoming We.
Degree: PhD, Faculty of Nursing, 2012, University of Alberta
URL: https://era.library.ualberta.ca/files/pn89d732v
► The patient teaching relationship is entwined within the dialogue between nurse and patient. Using interpretive phenomenology, consistent with the philosophy of Martin Heidegger, this research…
(more)
▼ The patient teaching relationship is entwined within
the dialogue between nurse and patient. Using interpretive
phenomenology, consistent with the philosophy of Martin Heidegger,
this research study explores the meaning of the relationships that
develop for patients with nurses during their learning experiences
about gestational diabetes mellitus. It affords a better
understanding of how patients engage with the Other in their mutual
relationships and what influences their Being-in-the-World. The
learning relationship occurs in the context of community, which,
for this study is the acute care nursing units and ambulatory
clinics that provide prenatal care for women experiencing
gestational diabetes. Understanding, for this exploratory study,
rests within the insight gained into the everyday experience of
patient education, within the relational pedagogical space where
patient and nurse connect as learner and teacher. A hermeneutical
spiral of interpretation was used to identify four major themes:
(1) Attuning to a New World Of Being: What is Happening to Me?; (2)
Towards A Connectedness With The Other: Attuning To Possibilities;
(3) Becoming We: Needing Creates Something Special and (4) Meeting
Expectations And Reconciling Differences. The findings of this
study have implications for patient education, nursing practice and
education, health policy and research.
Subjects/Keywords: Gestational Diabetes Mellitus; Phenomenology; Relational pedagogy; Heidegger; Interpretive Inquiry; Patient Education; Nursing
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Carson, G. A. (2012). Encountering the Other in Nurse-Patient Pedagogic
Relationships: Becoming We. (Doctoral Dissertation). University of Alberta. Retrieved from https://era.library.ualberta.ca/files/pn89d732v
Chicago Manual of Style (16th Edition):
Carson, Glenda A. “Encountering the Other in Nurse-Patient Pedagogic
Relationships: Becoming We.” 2012. Doctoral Dissertation, University of Alberta. Accessed January 18, 2021.
https://era.library.ualberta.ca/files/pn89d732v.
MLA Handbook (7th Edition):
Carson, Glenda A. “Encountering the Other in Nurse-Patient Pedagogic
Relationships: Becoming We.” 2012. Web. 18 Jan 2021.
Vancouver:
Carson GA. Encountering the Other in Nurse-Patient Pedagogic
Relationships: Becoming We. [Internet] [Doctoral dissertation]. University of Alberta; 2012. [cited 2021 Jan 18].
Available from: https://era.library.ualberta.ca/files/pn89d732v.
Council of Science Editors:
Carson GA. Encountering the Other in Nurse-Patient Pedagogic
Relationships: Becoming We. [Doctoral Dissertation]. University of Alberta; 2012. Available from: https://era.library.ualberta.ca/files/pn89d732v
◁ [1] [2] [3] [4] ▶
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Open Access Theses and Dissertations
