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You searched for subject:(Genes KIF7). One record found.

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Universidade Estadual de Campinas

1. Araujo, Tânia Kawasaki de, 1985-. Utilização da técnica de Open Array para investigação de genes associados a fendas labiopalatais em amostra da população brasileira: Association study between genes and cleft lip and palate in Brazilian population using the openarray technique.

Degree: 2015, Universidade Estadual de Campinas

Abstract: Nonsyndromic cleft lip and palate (NSCLP) is the most common craniofacial birth defect. The aim of this study was to evaluate associations between 39 genes and the etiology of NSCLP in a Brazilian population. This case-control association study was designed with 81.29% statistical power according to logistic regression. The case group was composed of 182 patients with NSCLP enrolled in the Brazilian Database on Orofacial Clefts. The controls included 355 healthy individuals with no history of oral clefting in the past three generations. All samples were genotyped by TaqMan®OpenArrayTM system for 253 single nucleotide polymorphisms (SNPs) in 39 genes, including two that had recently been associated with this process. The SNPs selection was made by SNPbrowser 4.0 (Applied Biosystems) in order to establish the best SNPs to explor the association between each gene and NSCLP. The association analysis was performed using logistic regression and stepwise regression. The results were corrected for multiple testing (Bonferroni correction). Twenty-four SNPs in 16 genes were significantly associated with the etiology of NSCLP, including MSX1, SPRY1, MSX2, PRSS35, TFAP2A, SHH, VAX1, TBX10, WNT11, PAX9, BMP4, JAG2, AXIN2, DVL2, KIF7 and TCBE3. Stepwise regression analysis revealed that 11 genes contributed to 15.5% of the phenotype of NSCLP in the sample. This is the first study to associate KIF7 and TCEB3 with NSCLP Advisors/Committee Members: UNIVERSIDADE ESTADUAL DE CAMPINAS (CRUESP), Lopes, Vera Lúcia Gil da Silva, 1967- (advisor), Secolin, Rodrigo (coadvisor), Universidade Estadual de Campinas. Faculdade de Ciências Médicas (institution), Programa de Pós-Graduação em Ciências Médicas (nameofprogram), Neves, Lucimara Teixeira das (committee member), Bicudo, Lucilene Arilho Ribeiro (committee member), Melo, Mônica Barbosa de (committee member), Morelli, Claudia Vianna Maurer (committee member).

Subjects/Keywords: Fenda labial; Fenda palatina; Estudos de casos e controles; Gene KIF7; Gene TCEB3; Cleft lip; Cleft palate; Case-control studies; Genes, KIF7; Genes, TCEB3

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APA (6th Edition):

Araujo, Tânia Kawasaki de, 1. (2015). Utilização da técnica de Open Array para investigação de genes associados a fendas labiopalatais em amostra da população brasileira: Association study between genes and cleft lip and palate in Brazilian population using the openarray technique. (Thesis). Universidade Estadual de Campinas. Retrieved from http://repositorio.unicamp.br/jspui/handle/REPOSIP/313118

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Araujo, Tânia Kawasaki de, 1985-. “Utilização da técnica de Open Array para investigação de genes associados a fendas labiopalatais em amostra da população brasileira: Association study between genes and cleft lip and palate in Brazilian population using the openarray technique.” 2015. Thesis, Universidade Estadual de Campinas. Accessed October 20, 2020. http://repositorio.unicamp.br/jspui/handle/REPOSIP/313118.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Araujo, Tânia Kawasaki de, 1985-. “Utilização da técnica de Open Array para investigação de genes associados a fendas labiopalatais em amostra da população brasileira: Association study between genes and cleft lip and palate in Brazilian population using the openarray technique.” 2015. Web. 20 Oct 2020.

Vancouver:

Araujo, Tânia Kawasaki de 1. Utilização da técnica de Open Array para investigação de genes associados a fendas labiopalatais em amostra da população brasileira: Association study between genes and cleft lip and palate in Brazilian population using the openarray technique. [Internet] [Thesis]. Universidade Estadual de Campinas; 2015. [cited 2020 Oct 20]. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/313118.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Araujo, Tânia Kawasaki de 1. Utilização da técnica de Open Array para investigação de genes associados a fendas labiopalatais em amostra da população brasileira: Association study between genes and cleft lip and palate in Brazilian population using the openarray technique. [Thesis]. Universidade Estadual de Campinas; 2015. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/313118

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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