subject:(Genes Homeobox MeSH )

Oregon State University

1. Bhatt, Shachi. Role of Pitx2 in regulation of cardiac remodelling.

Degree: MS, Genetics, 2008, Oregon State University

URL: http://hdl.handle.net/1957/9325

► Background: Heart morphogenesis involves chamber formation followed by septation. Septation is the remodeling of the heart from a single channel peristaltic pump to a two… (more)

Subjects/Keywords: Pitx2; Homeobox genes

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APA (6^th Edition):

Bhatt, S. (2008). Role of Pitx2 in regulation of cardiac remodelling. (Masters Thesis). Oregon State University. Retrieved from http://hdl.handle.net/1957/9325

Chicago Manual of Style (16^th Edition):

Bhatt, Shachi. “Role of Pitx2 in regulation of cardiac remodelling.” 2008. Masters Thesis, Oregon State University. Accessed January 15, 2021. http://hdl.handle.net/1957/9325.

MLA Handbook (7^th Edition):

Bhatt, Shachi. “Role of Pitx2 in regulation of cardiac remodelling.” 2008. Web. 15 Jan 2021.

Vancouver:

Bhatt S. Role of Pitx2 in regulation of cardiac remodelling. [Internet] [Masters thesis]. Oregon State University; 2008. [cited 2021 Jan 15]. Available from: http://hdl.handle.net/1957/9325.

Council of Science Editors:

Bhatt S. Role of Pitx2 in regulation of cardiac remodelling. [Masters Thesis]. Oregon State University; 2008. Available from: http://hdl.handle.net/1957/9325

University of Utah

2. Yun, Sanghee. The Roles of the LIM Homeobox Gene Lhx2 in Early Eye Development and Retinal Histogenesis.

Degree: PhD, Neurobiology & Anatomy, 2010, University of Utah

URL: http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/93/rec/1226

► The eye originates from the prosencephalon, a region of the brain. Eye development studies may assist research in the central nervous system (CNS), since several… (more)

▼ The eye originates from the prosencephalon, a region of the brain. Eye development studies may assist research in the central nervous system (CNS), since several CNS tissues (brain, spinal cord and eye etc.) exhibit similar gene expression profiles. In particular, homeobox genes have been shown to be crucial for patterning, specification and differentiation at tissue and cellular levels. Therefore, studying the function of single homeobox genes may be important for answering fundamental questions of developmental biology. In Chapter 1,1 review general eye structures and functions, and outline some genetic mutations causing anophthalmia (absence of eye) and microphthalmia (small eye). I focus on two developmental processes, patterning of optic vesicle and retinal histogenesis for this study. Moreover, molecular mechanisms are explored including the functions of homeobox genes involved in these two processes. Finally, the known functions of Lhx2 are introduced, which is crucial for eye development in several animal model systems. In Chapter 2,1 describe genetic inactivation experiments of Lhx2 and show that it plays important roles in optic vesicle patterning. Here, I tried to determine how Lhx2 inactivation causes anophthalmia and analyzed the expression patterns of both intrinsic and extrinsic factors crucial for optic vesicle patterning. I discovered that Lhx2 is required for optic vesicle patterning in both cell-autonomous and non-cell autonomous manners and surface ectoderm specification in a non-cell autonomous manner. In Chapter 3,1 describe experiments designed to test the function of Lhx2 in retinal progenitor cells by mating floxed Lhx2 mice with retinal specific ere line or inducible ere line. I discovered that Lhx2 is crucial for the maintenance of uncommitted progenitor cells, which have the potential to generate all cell types, by preventing cell cycle exit and differentiation. These studies also suggest that Lhx2 limits the acquisition of the biased progenitor state that has the capacity to generate only specific cell fates. In Chapter 4,1 summarize the diverse functions of Lhx2 during optic vesicle patterning and retinal histogenesis, and propose future studies that may help to elucidate molecular mechanisms mediated by Lhx2.

Subjects/Keywords: Eye; Homeobox Genes; Mice

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Yun, S. (2010). The Roles of the LIM Homeobox Gene Lhx2 in Early Eye Development and Retinal Histogenesis. (Doctoral Dissertation). University of Utah. Retrieved from http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/93/rec/1226

Chicago Manual of Style (16^th Edition):

Yun, Sanghee. “The Roles of the LIM Homeobox Gene Lhx2 in Early Eye Development and Retinal Histogenesis.” 2010. Doctoral Dissertation, University of Utah. Accessed January 15, 2021. http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/93/rec/1226.

MLA Handbook (7^th Edition):

Yun, Sanghee. “The Roles of the LIM Homeobox Gene Lhx2 in Early Eye Development and Retinal Histogenesis.” 2010. Web. 15 Jan 2021.

Vancouver:

Yun S. The Roles of the LIM Homeobox Gene Lhx2 in Early Eye Development and Retinal Histogenesis. [Internet] [Doctoral dissertation]. University of Utah; 2010. [cited 2021 Jan 15]. Available from: http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/93/rec/1226.

Council of Science Editors:

Yun S. The Roles of the LIM Homeobox Gene Lhx2 in Early Eye Development and Retinal Histogenesis. [Doctoral Dissertation]. University of Utah; 2010. Available from: http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/93/rec/1226

University of Utah

3. Ray, Russell Scott. An Examination of Chiropteran HoxD Regulation from an Evolutionary Perspective.

Degree: PhD, Human Genetics, 2010, University of Utah

URL: http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/1822/rec/78

► Here we present our efforts to develop a model system that is suitable for laboratory experiments addressing Chiropteran development, genetics and evolution. The bat, Myotis… (more)

▼ Here we present our efforts to develop a model system that is suitable for laboratory experiments addressing Chiropteran development, genetics and evolution. The bat, Myotis lucifugus was selected as a model organism to study Chiropteran biology. To build a model system, Myotis lucifugus specimens were collected from several locations across the United States. From the collected specimens, embryos and adult tissues were used to produce an assessment of embryonic development, primary cell cultures, and various genetic libraries. These resources were then used to investigate the Chiropteran HoxD complex. The HoxD 13 genomic locus was cloned and sequenced to derive a protein coding sequence, which showed strong conservation with the Human and mouse HOXD 13 proteins. HoxD 13 expression, however, was expanded in the Myotis lucifugus forelimb when compared to mouse. We therefore investigated the regulation of the HoxD complex by cloning and sequencing two Chiropteran global control regions (GCR) belonging to Myotis lucifugus and Rhinolophus ferrumequinum. The two Chiropteran GCRs were used in a series of unbiased triangulation alignments, looking for sequence changes that were shared between the two bat species but not found in Human or mouse GCRs. A number of exclusive Chiropteran changes were found regarding sequence order, large insertions, large deletions and small nucleotide changes. The GCR was finally examined in a mouse transgenic assay, to determine its activity domains. As compared with the previously reported Human GCR activity assay, we found new Chiropteran GCR activity domains in the stylopod and zeugopod that correlate with the expansion of HoxD 13 in the Chiropteran forelimb. Previously reported domains in the fore- and midbrains were absent, which also correlate with a mutation in a highly conserved tetrapod specific GCR sequence. In light of the proposed hypothesis that the highly clustered structure of Hox genes in tetrapods acts as a constraint against evolution in the absence of duplication events, our results suggest that the Hox genes are evolving in a circuitous route in the absence of duplications while respecting ancestral constraints.

Subjects/Keywords: Bats; Homeobox Genes; Myotis

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Ray, R. S. (2010). An Examination of Chiropteran HoxD Regulation from an Evolutionary Perspective. (Doctoral Dissertation). University of Utah. Retrieved from http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/1822/rec/78

Chicago Manual of Style (16^th Edition):

Ray, Russell Scott. “An Examination of Chiropteran HoxD Regulation from an Evolutionary Perspective.” 2010. Doctoral Dissertation, University of Utah. Accessed January 15, 2021. http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/1822/rec/78.

MLA Handbook (7^th Edition):

Ray, Russell Scott. “An Examination of Chiropteran HoxD Regulation from an Evolutionary Perspective.” 2010. Web. 15 Jan 2021.

Vancouver:

Ray RS. An Examination of Chiropteran HoxD Regulation from an Evolutionary Perspective. [Internet] [Doctoral dissertation]. University of Utah; 2010. [cited 2021 Jan 15]. Available from: http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/1822/rec/78.

Council of Science Editors:

Ray RS. An Examination of Chiropteran HoxD Regulation from an Evolutionary Perspective. [Doctoral Dissertation]. University of Utah; 2010. Available from: http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/1822/rec/78

University of Adelaide

4. Remiszewski, Jacqueline Lee. The role of Gbx2 in murine embryonic development : / by Jacqueline Lee Remiszewski.

Degree: 1999, University of Adelaide

URL: http://hdl.handle.net/2440/19603

► Experiments suggest that Gastrulation and Brain specific Homeobox 2 is more likely to function providing positional information along the anterior-posterior embryonic axis than to control… (more)

Subjects/Keywords: Homeobox genes

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APA (6^th Edition):

Remiszewski, J. L. (1999). The role of Gbx2 in murine embryonic development : / by Jacqueline Lee Remiszewski. (Thesis). University of Adelaide. Retrieved from http://hdl.handle.net/2440/19603

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Remiszewski, Jacqueline Lee. “The role of Gbx2 in murine embryonic development : / by Jacqueline Lee Remiszewski.” 1999. Thesis, University of Adelaide. Accessed January 15, 2021. http://hdl.handle.net/2440/19603.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Remiszewski, Jacqueline Lee. “The role of Gbx2 in murine embryonic development : / by Jacqueline Lee Remiszewski.” 1999. Web. 15 Jan 2021.

Vancouver:

Remiszewski JL. The role of Gbx2 in murine embryonic development : / by Jacqueline Lee Remiszewski. [Internet] [Thesis]. University of Adelaide; 1999. [cited 2021 Jan 15]. Available from: http://hdl.handle.net/2440/19603.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Remiszewski JL. The role of Gbx2 in murine embryonic development : / by Jacqueline Lee Remiszewski. [Thesis]. University of Adelaide; 1999. Available from: http://hdl.handle.net/2440/19603

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Utah

5. Cimbora, Daniel M. Molecular and genetic analysis of the Drosophila segmentation gene odd-paired a target of homeotic gene regulation in the embryonic midgut;.

Degree: PhD, Human Genetics;, 1996, University of Utah

URL: http://content.lib.utah.edu/cdm/singleitem/collection/etd1/id/247/rec/831

► During the process of animal development, initially uniform fields of cells acquire distinct identities. One manifestation of this process is the generation of unique morphology… (more)

▼ During the process of animal development, initially uniform fields of cells acquire distinct identities. One manifestation of this process is the generation of unique morphology within a metameric series, such as the segments of the Drosophila larva or the vertebrae of the mammalian skeleton. The Drosophila homeotic genes, and the homologous murine Hox genes, control morphologic diversification of the segmental pattern. These genes encode transcription factors that direct groups of cells down specific developmental pathways, by controlling the expression of so-called 'downstream' genes. To understand homeotic/Hox gene function, we must therefore identify these downstream genes and analyze their roles in mediating homeotic control of development. Unfortunately, few targets of the Drosophila homeotic genes, and even fewer of the murine Hox genes, have been identified. The work described here begins with a screen for novel targets of homeotic gene regulation. As a result of this screen, the Drosophila segmentation gene odd-paired was cloned and identified as a target of homeotic gene regulation. Genetic analysis demonstrates that odd-paired, like the homeotic genes that regulate its expression, is required for morphogenesis of specific constrictions in the embryonic midgut late in development. Temporal analysis of odd-paired function supports the hypothesis that odd-paired functions downstream of homeotic genes in the genetic hierarchy controlling midgut constriction formation. Phenotypic analysis also demonstrates that odd-paired is required in the early embryo, prior to homeotic gene expression, for segmental subdivision of the ectoderm and for formation of the mesodermal component of the midgut. Thus, odd-paired functions upstream of the homeotics to control ectodermal and mesodermal development, in addition to its proposed function downstream of the homeotics in controlling midgut constriction formation. Spatial analysis of odd-paired function in the early embryo suggests that inductive interactions between the ectoderm and mesoderm play a role in mesodermal development.

Subjects/Keywords: Genetics; Genes, Homeobox

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Cimbora, D. M. (1996). Molecular and genetic analysis of the Drosophila segmentation gene odd-paired a target of homeotic gene regulation in the embryonic midgut;. (Doctoral Dissertation). University of Utah. Retrieved from http://content.lib.utah.edu/cdm/singleitem/collection/etd1/id/247/rec/831

Chicago Manual of Style (16^th Edition):

Cimbora, Daniel M. “Molecular and genetic analysis of the Drosophila segmentation gene odd-paired a target of homeotic gene regulation in the embryonic midgut;.” 1996. Doctoral Dissertation, University of Utah. Accessed January 15, 2021. http://content.lib.utah.edu/cdm/singleitem/collection/etd1/id/247/rec/831.

MLA Handbook (7^th Edition):

Cimbora, Daniel M. “Molecular and genetic analysis of the Drosophila segmentation gene odd-paired a target of homeotic gene regulation in the embryonic midgut;.” 1996. Web. 15 Jan 2021.

Vancouver:

Cimbora DM. Molecular and genetic analysis of the Drosophila segmentation gene odd-paired a target of homeotic gene regulation in the embryonic midgut;. [Internet] [Doctoral dissertation]. University of Utah; 1996. [cited 2021 Jan 15]. Available from: http://content.lib.utah.edu/cdm/singleitem/collection/etd1/id/247/rec/831.

Council of Science Editors:

Cimbora DM. Molecular and genetic analysis of the Drosophila segmentation gene odd-paired a target of homeotic gene regulation in the embryonic midgut;. [Doctoral Dissertation]. University of Utah; 1996. Available from: http://content.lib.utah.edu/cdm/singleitem/collection/etd1/id/247/rec/831

University of Hong Kong

6. 陳俊良. Expression profiling and epigenetic regulation of Hox genes in cellular models of chondrogenesis.

Degree: 2010, University of Hong Kong

URL: http://hdl.handle.net/10722/128630

Subjects/Keywords: Chondrogenesis.; Homeobox genes.

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

陳俊良.. (2010). Expression profiling and epigenetic regulation of Hox genes in cellular models of chondrogenesis. (Thesis). University of Hong Kong. Retrieved from http://hdl.handle.net/10722/128630

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

陳俊良.. “Expression profiling and epigenetic regulation of Hox genes in cellular models of chondrogenesis.” 2010. Thesis, University of Hong Kong. Accessed January 15, 2021. http://hdl.handle.net/10722/128630.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

陳俊良.. “Expression profiling and epigenetic regulation of Hox genes in cellular models of chondrogenesis.” 2010. Web. 15 Jan 2021.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete

Vancouver:

陳俊良.. Expression profiling and epigenetic regulation of Hox genes in cellular models of chondrogenesis. [Internet] [Thesis]. University of Hong Kong; 2010. [cited 2021 Jan 15]. Available from: http://hdl.handle.net/10722/128630.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

陳俊良.. Expression profiling and epigenetic regulation of Hox genes in cellular models of chondrogenesis. [Thesis]. University of Hong Kong; 2010. Available from: http://hdl.handle.net/10722/128630

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation

Universidade Estadual de Campinas

7. Andrade, Simone Caixeta de, 1977-. Investigação do papel da homeoproteína BARX1 na morfogênese do dente molar em camundongos: Investigation of the role of BARX1 homeoprotein in molar tooth morphogenesis in mice.

Degree: 2012, Universidade Estadual de Campinas

URL: http://repositorio.unicamp.br/jspui/handle/REPOSIP/290038

► Abstract: The dentition is not only the largest component of the craniofacial complex of mammals, but a useful model of development, combined in a single… (more)

▼ Abstract: The dentition is not only the largest component of the craniofacial complex of mammals, but a useful model of development, combined in a single organ system, where phenomena of spatial organization, symmetry, complex shape acquisition and organ-specific cytodifferentiation occur. During the early stages of tooth development, series interactions take place between oral epithelial and mesenchyme by different signalling molecules along the future alveolar process. Bmp4 acts by activating Msx1 in the region of incisors and molars and it restricts the action of Barx1 only to the molars' region. The interaction between mesenchymal Bmp4 signal and Shh epithelial signal is part of the first events of tooth germ formation at the bud stage. The next stages are cap and bell. Mutations in Msx1 and Barx1 genes inhibit the development of the tooth germ beyond the bud stage. For the Msx1 gene, this condition is permanent, while for Barx1 is temporal and the growth of tooth germ is retaken after stage E14.5 in mice. This study investigates the genetic interaction between Msx1 and Barx1 in the first lower molar development at the bell stage (E16.5), the effect of the absence of Msx1 gene in the size of the vestigial structures MS, R2 and first lower molar bud (E13.5) and bell (E16.5). This study also aimed to assess whether Barx2, Barhl1 and Barhl2 genes were expressed in lower molars buds (E13.5). The results indicated that in the complete absence of Barx1, a single allele of Msx1 is not sufficient to promote the development of tooth bud to cap in E16.5 Barx1;Msx1 mice, and there was no expression of Bmp4 in these mice. The null expression of Barx2, Barhl1 and Barhl2 genes in lower molar buds in E13.5 wild-type mice indicates that genes of the Bar family do not exert any role in the development of lower molars. Still, allometric data on Msx1-/- (E13.5 and E16.5) indicates that Msx1 gene mutation and consequently the absence of Shh and SMAD1-5-8 expression do not prevent growth towards proximal-distal. It is concluded that there is interaction between Barx1 and Msx1. Barx1 is necessary to control the expression levels of Bmp4. Barx2 might play a role in the lower premolars and incisors morphogenesis. The delayed development of Msx1-/- lower molars is permanent at the bud stage, however, the tooth buds of these mice continue to exhibit growth towards proximal-distal at E16.5 stage Advisors/Committee Members: UNIVERSIDADE ESTADUAL DE CAMPINAS (CRUESP), Line, Sergio Roberto Peres, 1963- (advisor), Marques, Marcelo Rocha, 1976- (coadvisor), Universidade Estadual de Campinas. Faculdade de Odontologia de Piracicaba (institution), Programa de Pós-Graduação em Biologia Buco-Dental (nameofprogram), Gomes, Jose Rosa (committee member), Oliveira, Naila Francis Paulo de (committee member), Salmon, Cristiane Ribeiro (committee member), Andia, Denise Carleto (committee member).

Subjects/Keywords: Genes Homeobox; Fatores de transcrição; Histologia; Embriologia; Genes, Homeobox; Transcription factor; Histology; Embryology

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Andrade, Simone Caixeta de, 1. (2012). Investigação do papel da homeoproteína BARX1 na morfogênese do dente molar em camundongos: Investigation of the role of BARX1 homeoprotein in molar tooth morphogenesis in mice. (Thesis). Universidade Estadual de Campinas. Retrieved from http://repositorio.unicamp.br/jspui/handle/REPOSIP/290038

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Andrade, Simone Caixeta de, 1977-. “Investigação do papel da homeoproteína BARX1 na morfogênese do dente molar em camundongos: Investigation of the role of BARX1 homeoprotein in molar tooth morphogenesis in mice.” 2012. Thesis, Universidade Estadual de Campinas. Accessed January 15, 2021. http://repositorio.unicamp.br/jspui/handle/REPOSIP/290038.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Andrade, Simone Caixeta de, 1977-. “Investigação do papel da homeoproteína BARX1 na morfogênese do dente molar em camundongos: Investigation of the role of BARX1 homeoprotein in molar tooth morphogenesis in mice.” 2012. Web. 15 Jan 2021.

Vancouver:

Andrade, Simone Caixeta de 1. Investigação do papel da homeoproteína BARX1 na morfogênese do dente molar em camundongos: Investigation of the role of BARX1 homeoprotein in molar tooth morphogenesis in mice. [Internet] [Thesis]. Universidade Estadual de Campinas; 2012. [cited 2021 Jan 15]. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/290038.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Andrade, Simone Caixeta de 1. Investigação do papel da homeoproteína BARX1 na morfogênese do dente molar em camundongos: Investigation of the role of BARX1 homeoprotein in molar tooth morphogenesis in mice. [Thesis]. Universidade Estadual de Campinas; 2012. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/290038

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

8. Rodini, Camila de Oliveira. Expressão de transcritos de genes homeobox no carcinoma epidermóide de boca: análise por microarray, validação por qRT-PCR e relação com critérios clínicos de agressividade.

Degree: PhD, Patologia Bucal, 2009, University of São Paulo

URL: http://www.teses.usp.br/teses/disponiveis/23/23141/tde-08042009-112014/ ;

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A busca de marcadores moleculares para o refinamento diagnóstico, classificação e estabelecimento do prognóstico dos tumores, e individualização terapêutica tem sido foco de várias pesquisas.… (more)

▼

A busca de marcadores moleculares para o refinamento diagnóstico, classificação e estabelecimento do prognóstico dos tumores, e individualização terapêutica tem sido foco de várias pesquisas. O presente estudo teve como objetivo investigar, em carcinoma epidermóide de língua e/ou assoalho bucal, a presença de transcritos dos genes homeobox que pudessem se revelar marcadores moleculares de prognóstico e/ou agressividade tumoral. Após análise por microarray utilizando-se amostras de tumores e margens classificados como mais e menos agressivos, os genes homeobox HOXC13, HOXD10, HOXD11, IRX4, PROX1 e ZHX1 foram selecionados e sua hiper-expressão foi parcialmente validada por qRT-PCR. Observou-se aumento da expressão de HOXD10, HOXD11 e IRX4 em tumores com relação às margens correspondentes, bem como nos tumores menos agressivos em relação às suas respectivas margens. Por outro lado, os genes PROX1 e ZHX1 estavam mais expressos nas margens que nos tumores correspondentes. Esses resultados sugerem que a expressão alterada de HOXD10, HOXD11 e IRX4 pode participar no desenvolvimento do carcinoma epidermóide de língua e/ou assoalho bucal, enquanto os genes PROX1 e ZHX1 provavelmente exibem perda de função ou estão silenciados na neoplasia. Houve uma tendência de associação entre a expressão elevada de HOXD11 e presença de infiltrações linfática e perineural, e grau moderado de diferenciação da neoplasia, bem como entre a expressão elevada de HOXD10 e infiltração linfática. O gene IXR4 foi relacionado com um menor tempo de sobrevida global. Não foi possível estabelecer, dentre os genes homeobox validados por qRT-PCR, um gene ou uma combinação deles que pudesse(m) ser utilizado(s) como marcador(es) de agressividade tumoral.

The search for molecular markers to diagnosis improvement, treatment individualization and establishment of oral squamous cell carcinoma prognosis has been the focus of several studies. The present study investigated the presence of specific transcript of homeobox genes in squamous cell carcinoma of the tongue and/or floor of the mouth that might reflect relevant molecular markers of prognosis and/or tumor aggressiveness. After microarray analysis of tumor samples classified as more or less aggressive, and non tumoral margins, HOXC13, HOXD10, HOXD11, IRX4, PROX1 and ZHX1 selected and partially validated by qRT-PCR. Increased expression of HOXD10, HOXD11, IRX4 in tumors in comparison to margins as well as in less aggressive tumors related to their margins was observed. On the other hand, a decreased expression of PROX1 and ZHX1 was observed in margins compared to their respective tumors. These results suggest that the altered expression of HOXD10, HOXD11 and IRX4 may participate in the development of squamous cell carcinoma of the tongue and/or floor of the mouth, while PROX1 and ZHX1 probably present loss of function or are silenced in tumors. A tendency of association between increased expression of HOXD11 and lymphatic and perineural infiltration, as well as moderately differentiated tumors, and…

Advisors/Committee Members: Nunes, Fabio Daumas, Okamoto, Oswaldo Keith.

Subjects/Keywords: Carcinoma epidermóide de boca; Genes homeobox; Homeobox Genes; Oral squamous cell carcinoma; qRT-PCR; qRT-PCR

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Rodini, C. d. O. (2009). Expressão de transcritos de genes homeobox no carcinoma epidermóide de boca: análise por microarray, validação por qRT-PCR e relação com critérios clínicos de agressividade. (Doctoral Dissertation). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/23/23141/tde-08042009-112014/ ;

Chicago Manual of Style (16^th Edition):

Rodini, Camila de Oliveira. “Expressão de transcritos de genes homeobox no carcinoma epidermóide de boca: análise por microarray, validação por qRT-PCR e relação com critérios clínicos de agressividade.” 2009. Doctoral Dissertation, University of São Paulo. Accessed January 15, 2021. http://www.teses.usp.br/teses/disponiveis/23/23141/tde-08042009-112014/ ;.

MLA Handbook (7^th Edition):

Rodini, Camila de Oliveira. “Expressão de transcritos de genes homeobox no carcinoma epidermóide de boca: análise por microarray, validação por qRT-PCR e relação com critérios clínicos de agressividade.” 2009. Web. 15 Jan 2021.

Vancouver:

Rodini CdO. Expressão de transcritos de genes homeobox no carcinoma epidermóide de boca: análise por microarray, validação por qRT-PCR e relação com critérios clínicos de agressividade. [Internet] [Doctoral dissertation]. University of São Paulo; 2009. [cited 2021 Jan 15]. Available from: http://www.teses.usp.br/teses/disponiveis/23/23141/tde-08042009-112014/ ;.

Council of Science Editors:

Rodini CdO. Expressão de transcritos de genes homeobox no carcinoma epidermóide de boca: análise por microarray, validação por qRT-PCR e relação com critérios clínicos de agressividade. [Doctoral Dissertation]. University of São Paulo; 2009. Available from: http://www.teses.usp.br/teses/disponiveis/23/23141/tde-08042009-112014/ ;

University of Hong Kong

9. Wong, Pui-man, Molly. Hoxb3 mutation leads to interleukin-6 dependent plasmacytoma.

Degree: 2006, University of Hong Kong

URL: http://hdl.handle.net/10722/50205

Subjects/Keywords: Mutation (Biology); Plasmacytoma.; Homeobox genes.

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APA (6^th Edition):

Wong, Pui-man, M. (2006). Hoxb3 mutation leads to interleukin-6 dependent plasmacytoma. (Thesis). University of Hong Kong. Retrieved from http://hdl.handle.net/10722/50205

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Wong, Pui-man, Molly. “Hoxb3 mutation leads to interleukin-6 dependent plasmacytoma.” 2006. Thesis, University of Hong Kong. Accessed January 15, 2021. http://hdl.handle.net/10722/50205.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Wong, Pui-man, Molly. “Hoxb3 mutation leads to interleukin-6 dependent plasmacytoma.” 2006. Web. 15 Jan 2021.

Vancouver:

Wong, Pui-man M. Hoxb3 mutation leads to interleukin-6 dependent plasmacytoma. [Internet] [Thesis]. University of Hong Kong; 2006. [cited 2021 Jan 15]. Available from: http://hdl.handle.net/10722/50205.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Wong, Pui-man M. Hoxb3 mutation leads to interleukin-6 dependent plasmacytoma. [Thesis]. University of Hong Kong; 2006. Available from: http://hdl.handle.net/10722/50205

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Hong Kong

10. Cheng, Wai-chun. Studying Hoxb5 functions in enteric nervous system development by dominant-negative repressor engrailed-Hoxb5.

Degree: 2008, University of Hong Kong

URL: http://hdl.handle.net/10722/52786

Subjects/Keywords: Homeobox genes.; Gastrointestinal system.

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Cheng, W. (2008). Studying Hoxb5 functions in enteric nervous system development by dominant-negative repressor engrailed-Hoxb5. (Thesis). University of Hong Kong. Retrieved from http://hdl.handle.net/10722/52786

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Cheng, Wai-chun. “Studying Hoxb5 functions in enteric nervous system development by dominant-negative repressor engrailed-Hoxb5.” 2008. Thesis, University of Hong Kong. Accessed January 15, 2021. http://hdl.handle.net/10722/52786.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Cheng, Wai-chun. “Studying Hoxb5 functions in enteric nervous system development by dominant-negative repressor engrailed-Hoxb5.” 2008. Web. 15 Jan 2021.

Vancouver:

Cheng W. Studying Hoxb5 functions in enteric nervous system development by dominant-negative repressor engrailed-Hoxb5. [Internet] [Thesis]. University of Hong Kong; 2008. [cited 2021 Jan 15]. Available from: http://hdl.handle.net/10722/52786.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Cheng W. Studying Hoxb5 functions in enteric nervous system development by dominant-negative repressor engrailed-Hoxb5. [Thesis]. University of Hong Kong; 2008. Available from: http://hdl.handle.net/10722/52786

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Hong Kong

11. Wong, Shuk-ying, Esther. NANOG in ovarian cancer.

Degree: 2009, University of Hong Kong

URL: http://hdl.handle.net/10722/56613

Subjects/Keywords: Homeobox genes.; Ovaries - Cancer.

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Wong, Shuk-ying, E. (2009). NANOG in ovarian cancer. (Thesis). University of Hong Kong. Retrieved from http://hdl.handle.net/10722/56613

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Wong, Shuk-ying, Esther. “NANOG in ovarian cancer.” 2009. Thesis, University of Hong Kong. Accessed January 15, 2021. http://hdl.handle.net/10722/56613.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Wong, Shuk-ying, Esther. “NANOG in ovarian cancer.” 2009. Web. 15 Jan 2021.

Vancouver:

Wong, Shuk-ying E. NANOG in ovarian cancer. [Internet] [Thesis]. University of Hong Kong; 2009. [cited 2021 Jan 15]. Available from: http://hdl.handle.net/10722/56613.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Wong, Shuk-ying E. NANOG in ovarian cancer. [Thesis]. University of Hong Kong; 2009. Available from: http://hdl.handle.net/10722/56613

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Delaware

12. Bhatlekar, Seema. The role of HOX genes in regulating stem cell population in normal and malignant colon tissue.

Degree: PhD, University of Delaware, Department of Biological Sciences, 2014, University of Delaware

URL: http://udspace.udel.edu/handle/19716/13369

► Colorectal cancer (CRCs) is a leading cause of cancer-related deaths in the United States. Stem cells (SCs) that reside at the base of normal colonic… (more)

▼ Colorectal cancer (CRCs) is a leading cause of cancer-related deaths in the United States. Stem cells (SCs) that reside at the base of normal colonic crypts are functional units of the colon and over-population of SCs leads to colon tumorigenesis. This study was designed to better investigate regulatory mechanisms by which SCs are maintained in the normal colon and to determine what triggers their dysregulation during colon cancer development. HOX genes that are master regulatory transcription factors controlling development and organogenesis are seen to be aberrantly expressed in several cancers, including CRCs. The primary objective is to investigate the role of HOX genes in colon cancer development and to determine if HOX genes have a potential role in regulating the SC population of normal and malignant colonic tissues. A unique gene expression signature for human colonic SCs was identified using two-color microarray as a first step towards understanding regulatory mechanisms of colonic SCs. Our microarray results indicated that developmental genes, in particular HOXA4, HOXA9 and HOXD10 were upregulated in the crypt bottom (SC-enriched region) relative to middle and top sub-sections of colonic crypts. Accordingly, I hypothesized that " HOXA4, HOXA9 and HOXD10 genes are differentially expressed in normal and malignant colonic stem cells and aberrant expression of HOXA4, HOXA9 and HOXD10 genes is necessary for the self-renewal ability of colon cancer stem cells". The reason behind aberrant expression of HOX genes in CRCs is unknown. Real time PCR validated that HOXA4, HOXA9 and HOXD10 mRNAs are selectively expressed in the normal crypt bottom and are overexpressed in CRCs. Immunostaining showed that HOXA4, HOXA9 and HOXD10 proteins are co-expressed with the SC marker ALDH1 in cells at the normal crypt bottom, and the number of these co-expressing cells is increased in CRCs. HOXA4 and HOXA9 over-expression was also observed in colon CSCs that were isolated from SW480 and HT29 cancer cells. Thus, these findings showed that HOX genes are selectively expressed in colonic SCs and that HOX overexpression in CRCs parallels the SC overpopulation that occurs during CRC development. The study also suggests that developmental genes play key roles in the maintenance of normal SCs and crypt renewal, and contribute to the SC overpopulation that drives colon tumorigenesis. Because the mechanism by which HOX genes are contributing to the SC over population is unclear, functional studies were performed to investigate the role of HOX genes in regulating normal and malignant colonic SCs. Accordingly, siRNA-mediated knockdown of HOXA4 and HOXA9 in SW480 and HT29 cells was performed and the potential role of HOX genes in modulating proliferation and self-renewal ability of CSCs was evaluated. Our results revealed that proliferation of SW480 and HT29 cells transfected with either HOXA4 siRNA or HOXA9 siRNA was reduced compared to controls. It was also observed that HOXA4 and HOXA9 knockdown in SW480 and HT29 cells reduced gene… Advisors/Committee Members: Boman, Bruce M..

Subjects/Keywords: Homeobox genes.; Colon (Anatomy) – Cancer – Genetic aspects.; Tretinoin.

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Bhatlekar, S. (2014). The role of HOX genes in regulating stem cell population in normal and malignant colon tissue. (Doctoral Dissertation). University of Delaware. Retrieved from http://udspace.udel.edu/handle/19716/13369

Chicago Manual of Style (16^th Edition):

Bhatlekar, Seema. “The role of HOX genes in regulating stem cell population in normal and malignant colon tissue.” 2014. Doctoral Dissertation, University of Delaware. Accessed January 15, 2021. http://udspace.udel.edu/handle/19716/13369.

MLA Handbook (7^th Edition):

Bhatlekar, Seema. “The role of HOX genes in regulating stem cell population in normal and malignant colon tissue.” 2014. Web. 15 Jan 2021.

Vancouver:

Bhatlekar S. The role of HOX genes in regulating stem cell population in normal and malignant colon tissue. [Internet] [Doctoral dissertation]. University of Delaware; 2014. [cited 2021 Jan 15]. Available from: http://udspace.udel.edu/handle/19716/13369.

Council of Science Editors:

Bhatlekar S. The role of HOX genes in regulating stem cell population in normal and malignant colon tissue. [Doctoral Dissertation]. University of Delaware; 2014. Available from: http://udspace.udel.edu/handle/19716/13369

Columbia University

13. Gordon, Patricia Marie. A Competition Mechanism for a Homeotic Neuron Identity Transformation in Caenorhabditis Elegans.

Degree: 2015, Columbia University

URL: https://doi.org/10.7916/D87H1H90

► As embryos proceed through development, they must undergo a series of cell fate decisions. At each division, potency is progressively restricted until a terminally differentiated,… (more)

Subjects/Keywords: Caenorhabditis elegans; Caenorhabditis elegans – Genetics; Cell division; Cell differentiation; Homeobox genes

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APA (6^th Edition):

Gordon, P. M. (2015). A Competition Mechanism for a Homeotic Neuron Identity Transformation in Caenorhabditis Elegans. (Doctoral Dissertation). Columbia University. Retrieved from https://doi.org/10.7916/D87H1H90

Chicago Manual of Style (16^th Edition):

Gordon, Patricia Marie. “A Competition Mechanism for a Homeotic Neuron Identity Transformation in Caenorhabditis Elegans.” 2015. Doctoral Dissertation, Columbia University. Accessed January 15, 2021. https://doi.org/10.7916/D87H1H90.

MLA Handbook (7^th Edition):

Gordon, Patricia Marie. “A Competition Mechanism for a Homeotic Neuron Identity Transformation in Caenorhabditis Elegans.” 2015. Web. 15 Jan 2021.

Vancouver:

Gordon PM. A Competition Mechanism for a Homeotic Neuron Identity Transformation in Caenorhabditis Elegans. [Internet] [Doctoral dissertation]. Columbia University; 2015. [cited 2021 Jan 15]. Available from: https://doi.org/10.7916/D87H1H90.

Council of Science Editors:

Gordon PM. A Competition Mechanism for a Homeotic Neuron Identity Transformation in Caenorhabditis Elegans. [Doctoral Dissertation]. Columbia University; 2015. Available from: https://doi.org/10.7916/D87H1H90

Hong Kong University of Science and Technology

14. Zhou, Bo. Structural studies of geminin-hox and smad-hox complexes.

Degree: 2007, Hong Kong University of Science and Technology

URL: http://repository.ust.hk/ir/Record/1783.1-3159 ; https://doi.org/10.14711/thesis-b1006753 ; http://repository.ust.hk/ir/bitstream/1783.1-3159/1/th_redirect.html

► Embryonic development is tightly controlled. The clustered genes of the Hox family of homeobox proteins play an important part in regulating this development and also… (more)

▼ Embryonic development is tightly controlled. The clustered genes of the Hox family of homeobox proteins play an important part in regulating this development and also proliferation. They specify embryonic structures along the body axis, and are associated with normal and malignant cell growth. The cell cycle regulator, Geminin, controls replication by binding to the licensing factor Cdt1, and is involved in neural differentiation. Recently, the interaction between Geminin and Hox proteins was found to prevent Hox proteins from binding to DNA, inhibit Hox-dependent transcriptional activation of reporter and endogenous downstream target genes, and displace Cdt1 from its complex with Geminin. By establishing competitive regulation, Geminin functions as a coordinator of developmental and proliferative control. To understand molecular basis of interaction between Geminin and Hox proteins, structural information of this complex is essential. NMR titration experiment was used to demonstrate the interaction between the coiled-coil domain of Geminin and homeodomain of Hox protein and to map the interaction regions on Hox proteins. Based on the backbone assignment of Hox, it indicates that the N-terminal and C-terminal section of homeodomain is involved in strong binding. Almost all the assignment of backbone and sidechain atoms of both domains was completed. The structures of bound forms of both domains were calculated by Cyana with NOE distance constraints and backbone dihedral angle constraints obtained from TALOS. Intermolecular NOE constraints were used to dock these two bound forms together. In addition, the luciferase assay system was used to examine whether Geminin and the coiled-coil domain inhibit the transcriptional activation promoted by Hox in vivo. In the second part, the Hox-Smad complex was studied. Hox proteins have been identified as downstream transcription factors of TGFβ/BMP signaling pathways. Smad family proteins mediate signaling initiated by BMPs and upon TGFβ/BMP stimulation the common Smad, Smad4, can interact directly with Hox proteins and suppresses their DNA-binding activity. Although the interaction between the Smad4 MH1 domain and Hox homeodomain was found to regulate the transcription activity of Hox proteins, the mechanism is not well characterized and direct contact residues remain to be elucidated. In the present study, the interaction between the recombinant Hoxc9 homeodomain and Smad4 MH1 domain was investigated using GST pull-down assay, surface plasmon resonance (SPR) analysis as well as multidimensional nuclear magnetic resonance (NMR) techniques. Hoxc9 was precipitated with the GST-Smad4 MH1 fusion protein but not with GST alone, demonstrating a direct interaction between the two domains in vitro. Titration experiments showed that a strong and specific binding occurred between the two domains. NMR triple-resonance experiments and backbone assignments revealed that the N terminal arm of Hoxc9 was involved in the interaction with Smad4 MH1. In addition, SPR measurement verified a…

Subjects/Keywords: Homeobox genes ; Genetic translation

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APA (6^th Edition):

Zhou, B. (2007). Structural studies of geminin-hox and smad-hox complexes. (Thesis). Hong Kong University of Science and Technology. Retrieved from http://repository.ust.hk/ir/Record/1783.1-3159 ; https://doi.org/10.14711/thesis-b1006753 ; http://repository.ust.hk/ir/bitstream/1783.1-3159/1/th_redirect.html

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Zhou, Bo. “Structural studies of geminin-hox and smad-hox complexes.” 2007. Thesis, Hong Kong University of Science and Technology. Accessed January 15, 2021. http://repository.ust.hk/ir/Record/1783.1-3159 ; https://doi.org/10.14711/thesis-b1006753 ; http://repository.ust.hk/ir/bitstream/1783.1-3159/1/th_redirect.html.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Zhou, Bo. “Structural studies of geminin-hox and smad-hox complexes.” 2007. Web. 15 Jan 2021.

Vancouver:

Zhou B. Structural studies of geminin-hox and smad-hox complexes. [Internet] [Thesis]. Hong Kong University of Science and Technology; 2007. [cited 2021 Jan 15]. Available from: http://repository.ust.hk/ir/Record/1783.1-3159 ; https://doi.org/10.14711/thesis-b1006753 ; http://repository.ust.hk/ir/bitstream/1783.1-3159/1/th_redirect.html.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Zhou B. Structural studies of geminin-hox and smad-hox complexes. [Thesis]. Hong Kong University of Science and Technology; 2007. Available from: http://repository.ust.hk/ir/Record/1783.1-3159 ; https://doi.org/10.14711/thesis-b1006753 ; http://repository.ust.hk/ir/bitstream/1783.1-3159/1/th_redirect.html

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Illinois – Urbana-Champaign

15. Nallasamy, Shanmugasundaram. Role of Msx homeobox genes in uterus during embryo implantation.

Degree: PhD, 5274, 2012, University of Illinois – Urbana-Champaign

URL: http://hdl.handle.net/2142/32038

► Implantation of the embryo into the wall of the uterus is a crucial event in mammalian embryogenesis. This complex event involves a series of interactions… (more)

▼ Implantation of the embryo into the wall of the uterus is a crucial event in mammalian embryogenesis. This complex event involves a series of interactions between the developing embryo and the receptive endometrium ultimately leading to successful establishment of pregnancy. The sequential events of implantation include apposition of the blastocyst to the uterine luminal epithelium followed by adhesion to the epithelium and then penetration through the epithelium and basal lamina into the uterine stroma. Uterine sensitivity with respect to implantation has been classified as prereceptive, receptive, and nonreceptive phases. In the mouse, day 1–3 of pregnancy constitutes the prereceptive phase and day 4 is considered receptive. The window of uterine receptivity is transient and lasts for a limited time. On day 5 of pregnancy, the uterus is nonreceptive or refractory. Studies over the past decade have identified a variety of molecules including growth factors, cytokines, transcription factors, and extracellular matrix proteins as potential regulators of this complex process. This dissertation work investigates the critical role of Msx homeobox genes in the uterus during embryo implantation. The mammalian Msx homeobox genes, Msx1 and Msx2, encode transcription factors that control organogenesis and tissue interactions during embryonic development. Uterine specific deletion of Msx1 and Msx2 resulted in female infertility due to a failure in implantation. Further analysis indicated that mice lacking uterine Msx1 and Msx2 (Msx1d/dMsx2d/d) exhibited a failure in uterine receptivity due to enhanced estrogen signaling in the luminal epithelium, failure of microvilli remodeling, sustained epithelial cell polarity and persistent proliferative activity of luminal and glandular epithelium. More recent studies revealed that canonical Wnt/ β-catenin signaling were upregulated in the Msx1Msx2-null uteri, which in turn stimulated the production of a subset of fibroblast growth factors (FGFs) in the stromal cells. The FGFs subsequently activate FGFR-ERK-MAP kinase signaling pathway in the luminal epithelium resulting in sustained epithelial cellular proliferation. These results uncovered a unique signaling network, involving Msx1/2, Wnts, and FGFs, which regulate stromal-epithelial cross talk in the mouse uterus at the time of receptivity. The last chapter addresses the role of Msx homeobox genes during uterine stromal cell decidualization. As the embryo attaches to the uterine wall and invades into the stromal bed, the stromal cells surrounding the implanting blastocyst differentiate into decidual cells in a process known as decidualization. This process is critical for embryo survival, angiogenesis and successful establishment of pregnancy. We previously reported that Bone morphogenetic protein 2 (BMP2) regulates uterine stromal cell differentiation in the mouse and the human. Subsequent studies revealed that the expressions of Msx1 and Msx2 were markedly altered in response to exogenous BMP2. Functional studies performed using… Advisors/Committee Members: Bagchi, Indrani C. (advisor), Bagchi, Indrani C. (Committee Chair), Bagchi, Milan K. (committee member), Flaws, Jodi A. (committee member), Miller, Suzanne E. (committee member).

Subjects/Keywords: Msx homeobox genes; uterus; embryo implantation; uterine receptivity; decidualization; Mouse; Human

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APA (6^th Edition):

Nallasamy, S. (2012). Role of Msx homeobox genes in uterus during embryo implantation. (Doctoral Dissertation). University of Illinois – Urbana-Champaign. Retrieved from http://hdl.handle.net/2142/32038

Chicago Manual of Style (16^th Edition):

Nallasamy, Shanmugasundaram. “Role of Msx homeobox genes in uterus during embryo implantation.” 2012. Doctoral Dissertation, University of Illinois – Urbana-Champaign. Accessed January 15, 2021. http://hdl.handle.net/2142/32038.

MLA Handbook (7^th Edition):

Nallasamy, Shanmugasundaram. “Role of Msx homeobox genes in uterus during embryo implantation.” 2012. Web. 15 Jan 2021.

Vancouver:

Nallasamy S. Role of Msx homeobox genes in uterus during embryo implantation. [Internet] [Doctoral dissertation]. University of Illinois – Urbana-Champaign; 2012. [cited 2021 Jan 15]. Available from: http://hdl.handle.net/2142/32038.

Council of Science Editors:

Nallasamy S. Role of Msx homeobox genes in uterus during embryo implantation. [Doctoral Dissertation]. University of Illinois – Urbana-Champaign; 2012. Available from: http://hdl.handle.net/2142/32038

University of Hawaii – Manoa

16. Turano, Brian. Paragenetic studies of TgHbox1 during sea urchin embryogenesis.

Degree: PhD, 2009, University of Hawaii – Manoa

URL: http://hdl.handle.net/10125/9408

►

Microfiche.

x, 117 leaves, bound ill. (some col.) 29 cm

The HOM-C homeobox genes are responsible for regional specification along the anterior-posterior axis of the… (more)

▼

Microfiche.

x, 117 leaves, bound ill. (some col.) 29 cm

The HOM-C homeobox genes are responsible for regional specification along the anterior-posterior axis of the embryo which results in the determination of body structures. TgHbox1, an Antennapedia-class homeobox gene related to homeobox genes in the HOM-C cluster has been previously described in the sea urchin Tripneustes gratilla (Dolecki et aI., 1986). This dissertation is an investigation into the function of the TgHbox1 gene during sea urchin embryogenesis. Due to the lack of the ability to perform classical genetic studies to examine gene function in the sea urchin, a paragenetic approach was designed. This was accomplished by microinjection of batches of sea urchin eggs with one of the following gene-specific reagents: phosphorothioate-modified oligonucleotides with TgHbox1 antisense sequence, TgHbox1-specific polyclonal antibodies, a synthetic lacZ-TgHbox1 fusion mRNA encoding a potential dominant negative protein, or a bacterially expressed truncated TgHbox1 protein to inhibit function of the endogenous protein. The embryos were fertilized and followed visually through embryogenesis. The authenticity of all reagents was confirmed in vitro as well as in vivo. Additionally, the persistence of the reagents or their products were demonstrated to be in excess of the endogenous target molecules and to be present in the embryo during the relevant development stages. Morphological analysis of the embryos injected with the four different TgHbox1-specific reagents yielded no specific mutant embryonic phenotype or perturbation of embryogenesis. The findings suggest are consistent with any of the following: TgHbox1 function was not inhibited sufficiently by any of the gene-specific reagents, redundant homeobox genes or other genes were able to functionally compensate for the loss of TgHbox1 gene function, TgHbox1 has no function in the stages of development studied, or there was an unidentified conceptual or experimental flaw in each of the four approaches.

Subjects/Keywords: Sea urchins – Genetics; Homeobox genes

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APA (6^th Edition):

Turano, B. (2009). Paragenetic studies of TgHbox1 during sea urchin embryogenesis. (Doctoral Dissertation). University of Hawaii – Manoa. Retrieved from http://hdl.handle.net/10125/9408

Chicago Manual of Style (16^th Edition):

Turano, Brian. “Paragenetic studies of TgHbox1 during sea urchin embryogenesis.” 2009. Doctoral Dissertation, University of Hawaii – Manoa. Accessed January 15, 2021. http://hdl.handle.net/10125/9408.

MLA Handbook (7^th Edition):

Turano, Brian. “Paragenetic studies of TgHbox1 during sea urchin embryogenesis.” 2009. Web. 15 Jan 2021.

Vancouver:

Turano B. Paragenetic studies of TgHbox1 during sea urchin embryogenesis. [Internet] [Doctoral dissertation]. University of Hawaii – Manoa; 2009. [cited 2021 Jan 15]. Available from: http://hdl.handle.net/10125/9408.

Council of Science Editors:

Turano B. Paragenetic studies of TgHbox1 during sea urchin embryogenesis. [Doctoral Dissertation]. University of Hawaii – Manoa; 2009. Available from: http://hdl.handle.net/10125/9408

University of Hong Kong

17. Jakt, Lars Martin. Isolation of mouse Hoxb-3 protein binding sequences: a whole genome approach.

Degree: 1999, University of Hong Kong

URL: http://hdl.handle.net/10722/39628

Subjects/Keywords: Homeobox genes.; Genomes.; Mice - Genetics.

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APA (6^th Edition):

Jakt, L. M. (1999). Isolation of mouse Hoxb-3 protein binding sequences: a whole genome approach. (Thesis). University of Hong Kong. Retrieved from http://hdl.handle.net/10722/39628

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Jakt, Lars Martin. “Isolation of mouse Hoxb-3 protein binding sequences: a whole genome approach.” 1999. Thesis, University of Hong Kong. Accessed January 15, 2021. http://hdl.handle.net/10722/39628.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Jakt, Lars Martin. “Isolation of mouse Hoxb-3 protein binding sequences: a whole genome approach.” 1999. Web. 15 Jan 2021.

Vancouver:

Jakt LM. Isolation of mouse Hoxb-3 protein binding sequences: a whole genome approach. [Internet] [Thesis]. University of Hong Kong; 1999. [cited 2021 Jan 15]. Available from: http://hdl.handle.net/10722/39628.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Jakt LM. Isolation of mouse Hoxb-3 protein binding sequences: a whole genome approach. [Thesis]. University of Hong Kong; 1999. Available from: http://hdl.handle.net/10722/39628

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Hong Kong

18. 黃偉文. Generation and characterization of polyclonal antibodies specific to the mouse homeodomain protein HOXB-3.

Degree: 1999, University of Hong Kong

URL: http://hdl.handle.net/10722/33680

Subjects/Keywords: Immunoglobulins.; Homeobox genes.; Mice - Genetics.

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APA (6^th Edition):

黃偉文. (1999). Generation and characterization of polyclonal antibodies specific to the mouse homeodomain protein HOXB-3. (Thesis). University of Hong Kong. Retrieved from http://hdl.handle.net/10722/33680

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

黃偉文. “Generation and characterization of polyclonal antibodies specific to the mouse homeodomain protein HOXB-3.” 1999. Thesis, University of Hong Kong. Accessed January 15, 2021. http://hdl.handle.net/10722/33680.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

黃偉文. “Generation and characterization of polyclonal antibodies specific to the mouse homeodomain protein HOXB-3.” 1999. Web. 15 Jan 2021.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete

Vancouver:

黃偉文. Generation and characterization of polyclonal antibodies specific to the mouse homeodomain protein HOXB-3. [Internet] [Thesis]. University of Hong Kong; 1999. [cited 2021 Jan 15]. Available from: http://hdl.handle.net/10722/33680.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

黃偉文. Generation and characterization of polyclonal antibodies specific to the mouse homeodomain protein HOXB-3. [Thesis]. University of Hong Kong; 1999. Available from: http://hdl.handle.net/10722/33680

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation

University of Hong Kong

19. Ling, Kam-wing. Study of transgenic mice ectopically expressing the mouse Hoxb-3 gene.

Degree: 1998, University of Hong Kong

URL: http://hdl.handle.net/10722/35760

Subjects/Keywords: Homeobox genes.; Transgenic mice.

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Ling, K. (1998). Study of transgenic mice ectopically expressing the mouse Hoxb-3 gene. (Thesis). University of Hong Kong. Retrieved from http://hdl.handle.net/10722/35760

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Ling, Kam-wing. “Study of transgenic mice ectopically expressing the mouse Hoxb-3 gene.” 1998. Thesis, University of Hong Kong. Accessed January 15, 2021. http://hdl.handle.net/10722/35760.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Ling, Kam-wing. “Study of transgenic mice ectopically expressing the mouse Hoxb-3 gene.” 1998. Web. 15 Jan 2021.

Vancouver:

Ling K. Study of transgenic mice ectopically expressing the mouse Hoxb-3 gene. [Internet] [Thesis]. University of Hong Kong; 1998. [cited 2021 Jan 15]. Available from: http://hdl.handle.net/10722/35760.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Ling K. Study of transgenic mice ectopically expressing the mouse Hoxb-3 gene. [Thesis]. University of Hong Kong; 1998. Available from: http://hdl.handle.net/10722/35760

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

20. Antunes, Thaís Acquafreda. Perfil da expressão de genes homeobox em linhagens celulares de carcinoma epidermóide de boca estimuladas pelo ácido retinóico.

Degree: PhD, Patologia Bucal, 2009, University of São Paulo

URL: http://www.teses.usp.br/teses/disponiveis/23/23141/tde-19122009-121750/ ;

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O carcinoma epidermóide de boca, neoplasia maligna de boca mais comum, pode originar-se de lesões potencialmente malignas. O ácido retinóico, que atua no crescimento e… (more)

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O carcinoma epidermóide de boca, neoplasia maligna de boca mais comum, pode originar-se de lesões potencialmente malignas. O ácido retinóico, que atua no crescimento e diferenciação celular, tem sido comumente estudado como um possível quimioterápico na prevenção dessa progressão. Embora o mecanismo pelo qual o ácido retinóico previne essa progressão, e promove a parada do crescimento celular, não esteja estabelecido, sabe-se que os genes homeobox são importantes alvos do ácido retinóico durante o desenvolvimento embrionário e diferenciação tecidual. Este estudo visa determinar se a modulação da expressão desses genes está envolvida na inibição do crescimento pelo ácido retinóico em carcinoma epidermóide de boca. Para isso, foi realizado PCR array para avaliar a expressão de 84 genes homeobox na linhagem celular de carcinoma epidermóide de boca sensível ao ácido retinóico SSC-25, comparando com a linhagem resistente, SSC-9, após o tratamento com ácido retinóico por sete dias. Os resultados mostraram nove genes com perda de expressão e quatro com alta expressão. A validação por qPCR de 7 desses genes confirmou os resultados. Desses, três genes(ALX1, DLX3, TLX1) foram selecionados para terem a expressão avaliada em amostras tratadas por 3, 5 e 7 dias. O gene ALX1 apresentou baixa expressão apenas no dia 7. O gene DLX3 apresentou baixa expressão no terceiro dia com maior decréscimo no sétimo. Já o gene TLX1, mostrou baixa significativa no quinto dia, com valores semelhantes no sétimo. Os dados mostram genes homebox são modulados pelo ácido retinóico em linhagens de carcinoma epidermóide de boca. No entanto, esses genes não parecem ser alvo direto da inibição do crescimento promovida pelo ácido retinóico.

Oral squamous cell carcinoma, the most frequent oral cancer, may arise from potentially malignant oral lesions. Retinoic acid, which plays a role in cell growth and differentiation, has been frequently studied as a possible chemotherapeutic agent in the prevention of this progression. While the mechanism by which retinoic acid prevents progression and suppresses cell growth has not been completely elucidated, it is known that homeobox genes represent important targets of retinoic acid during embryogenesis and differentiation. The present study aims to determine if modulation of the expression of these genes is involved in inhibition of OSCC cell growth by retinoic acid. In order to achieve this goal a PCR array was performed to evaluate the expression of 84 homeobox genes in retinoic acid sensitive SCC-25 cells compared to retinoic acid resistant SCC-9 cells following treatment with retinoic acid for 7 days. Results showed that 9 homeobox genes are downregulated and 4 are upregulated by retinoic acid. The validation confirmed these results. Three genes (ALX1, DLX3, TLX1) were selected for having their expression evaluated on samples treated with retinoic acid for 3, 5 and 7 days. Three different patterns of gene expression were observed. Gene ALX1 showed down-regulation only on day 7. Homeobox gene DLX3 showed…

Advisors/Committee Members: Nunes, Fabio Daumas.

Subjects/Keywords: Carcinoma de Células Escamosas; Genes Homeobox; Homebox genes; Retinóides; Retinoids; Squamous cell carcinoma

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Antunes, T. A. (2009). Perfil da expressão de genes homeobox em linhagens celulares de carcinoma epidermóide de boca estimuladas pelo ácido retinóico. (Doctoral Dissertation). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/23/23141/tde-19122009-121750/ ;

Chicago Manual of Style (16^th Edition):

Antunes, Thaís Acquafreda. “Perfil da expressão de genes homeobox em linhagens celulares de carcinoma epidermóide de boca estimuladas pelo ácido retinóico.” 2009. Doctoral Dissertation, University of São Paulo. Accessed January 15, 2021. http://www.teses.usp.br/teses/disponiveis/23/23141/tde-19122009-121750/ ;.

MLA Handbook (7^th Edition):

Antunes, Thaís Acquafreda. “Perfil da expressão de genes homeobox em linhagens celulares de carcinoma epidermóide de boca estimuladas pelo ácido retinóico.” 2009. Web. 15 Jan 2021.

Vancouver:

Antunes TA. Perfil da expressão de genes homeobox em linhagens celulares de carcinoma epidermóide de boca estimuladas pelo ácido retinóico. [Internet] [Doctoral dissertation]. University of São Paulo; 2009. [cited 2021 Jan 15]. Available from: http://www.teses.usp.br/teses/disponiveis/23/23141/tde-19122009-121750/ ;.

Council of Science Editors:

Antunes TA. Perfil da expressão de genes homeobox em linhagens celulares de carcinoma epidermóide de boca estimuladas pelo ácido retinóico. [Doctoral Dissertation]. University of São Paulo; 2009. Available from: http://www.teses.usp.br/teses/disponiveis/23/23141/tde-19122009-121750/ ;

Freie Universität Berlin

21. Krämer, Nadine. Developmental molecular factors of the dentate gyrus in mice.

Degree: 2008, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-8178

► The dentate gyrus provides a good model for diverse areas of research concerning the cortical development, especially neurogenesis, neuronal migration, regionalization, axonal guidance and neuronal… (more)

▼ The dentate gyrus provides a good model for diverse areas of research concerning the cortical development, especially neurogenesis, neuronal migration, regionalization, axonal guidance and neuronal plasticity. Furthermore, the dentate gyrus has the special ability to produce functional neurons out of neuronal precursors the whole life long. Therefore it is an interesting object of research for potential neuronal processes of regeneration in the cortex. The aim of this study was to identify molecular factors of dentate gyrus development and to analyse their functions. The subject of the experiments was a comparison of expression patterns from Emx2-/- mutant versus wildtype mouse, because the transcription factor Emx2 plays a key role in hippocampal development. Thus, mice deficient in this factor show very specific developmental alterations in the hippocampus, which leads to the absence of a morphologically visible dentate gyrus in these Emx2-/- mutants. First some known genes, whose functions had already been described in literature extensively, were analysed during development by in situ hybridisation. Thereby investigating the different functional circuits like proliferation, differentiation and migration as well as the structural alterations of the dentate gyrus and the adjacent hippocampal fissure and marginal zone were of particular interest. Furthermore some candidate genes, for which a putative relation to Emx2 had not been described previously, were identified by screening microarrays. The results show that, in the Emx2-/- mutant dentate gyrus, the proneural cascade of bHLH genes is present, but abnormally confined to the germinal layer, the neuronal and glial migrating precursors are nearly absent, the glial scaffold is defective, the few produced astrocytes and granule cells are not able to migrate to their proper destination and in addition the granule cells are deficiently differentiated. The glial scaffolding is also lacking in the Emx2-/- mutant developing hippocampal fissure. The inner marginal zone (IMZ) seems to be developed properly, in contrast the outer marginal zone (OMZ) as well as the dentate marginal zone (DMZ) is atrophic. Most of the Reln-expressing cells that should occupy the OMZ and DMZ are missing, except a specific subpopulation, characterized by using additional markers, probably born in the hem and for which Emx2 is not essentially required. The microarray analysis reveals a group of genes whose expression is reduced in the Emx2-/- hippocampus. For most of them a putative relation to Emx2 pathways had not been recognized previously. Some candidates are development genes or are involved in functional maturation and show expression in the hippocampal plate and/or developing dentate gyrus. A second group of candidates labels neuronal, glial or vascular structures in the OMZ and likely represent markers for cell populations specifically absent in the mutant. The lack of these genes points at different pathways and processes altered in the Emx2-/-mutant, particularly the Notch and… Advisors/Committee Members: n (gender), Univ.-Prof. Dr. H. Martens (firstReferee), Univ.-Prof. Dr. T. Skutella (furtherReferee), Univ.-Prof. Dr. H. Fink (furtherReferee).

Subjects/Keywords: Mice, hippocampus, embryonic development, neurons, migration, genes; Genes, Homeobox (MeSH); gene expression; Gene Expression Regulation, Developmental (MeSH); transcription factors, neuroglia, polymerase chain reaction, DNA microarrays, in-situ hybridization; 600 Technik, Medizin, angewandte Wissenschaften::630 Landwirtschaft

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Krämer, N. (2008). Developmental molecular factors of the dentate gyrus in mice. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-8178

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Krämer, Nadine. “Developmental molecular factors of the dentate gyrus in mice.” 2008. Thesis, Freie Universität Berlin. Accessed January 15, 2021. http://dx.doi.org/10.17169/refubium-8178.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Krämer, Nadine. “Developmental molecular factors of the dentate gyrus in mice.” 2008. Web. 15 Jan 2021.

Vancouver:

Krämer N. Developmental molecular factors of the dentate gyrus in mice. [Internet] [Thesis]. Freie Universität Berlin; 2008. [cited 2021 Jan 15]. Available from: http://dx.doi.org/10.17169/refubium-8178.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Krämer N. Developmental molecular factors of the dentate gyrus in mice. [Thesis]. Freie Universität Berlin; 2008. Available from: http://dx.doi.org/10.17169/refubium-8178

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

22. Chile, Thais. Análise funcional e expressão do gene homeobox HOXB7 em adenocarcinomas pancreáticos ductais.

Degree: PhD, Endocrinologia, 2013, University of São Paulo

URL: http://www.teses.usp.br/teses/disponiveis/5/5135/tde-10052013-113753/ ;

►

O adenocarcinoma pancreático ductal representa a quarta causa de morte por câncer, visto que as taxas de incidência são praticamente idênticas às taxas de mortalidade,… (more)

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O adenocarcinoma pancreático ductal representa a quarta causa de morte por câncer, visto que as taxas de incidência são praticamente idênticas às taxas de mortalidade, o que justifica a natureza altamente agressiva do tumor. Em uma análise preliminar realizada por nosso grupo, avaliou-se a expressão do gene homeobox HOXB7 nas linhagens celulares MIA PaCa-2, BxPC-3 e Capan-1, bem como em tecidos pancreáticos normais, detectando-se o aumento significativo da expressão nas células derivadas de adenocarcinoma pancreático. Alterações na expressão de HOXB7 foram relatadas na formação e progressão de outros cânceres. Nessas condições, este estudo visou não somente avaliar a expressão deste gene em uma série de 29 adenocarcinomas pancreáticos ductais, 6 tecidos metastáticos e 24 tecidos peritumorais, comparando-os aos tecidos normais, mas também averiguar o efeito de sua inibição sobre o perfil de expressão das células citadas. A análise da expressão gênica demonstrou a hiperregulação do transcrito do gene HOXB7 nos tecidos tumorais, corroborando os resultados observados nas linhagens celulares MIA PaCa-2, BxPC-3 e Capan-1. A inibição realizada com RNA de interferência promoveu a modulação de diferentes processos biológicos nas três linhagens celulares pesquisadas, bem como a indução de apoptose e diminuição da proliferação das células MIA PaCa-2. Nesse contexto, o homeobox neste estudo investigado representa mais um componente associado à ampla rede de moléculas envolvidas na caracterização do câncer pancreático e um promissor alvo para futuras terapias biológicas

The pancreatic ductal adenocarcinoma is the fourth leading cause of cancer death, whereas the incidence rates are practically identical to mortality rates, which explains the highly aggressive tumor. In a preliminary analysis performed by our group, we evaluated the expression of the homeobox gene HOXB7 in cell lineages MIA PaCa-2, BxPC-3 and Capan-1, as well as in normal pancreatic tissue, detecting a significant increase in expression in cells derived from pancreatic adenocarcinoma. Changes in expression of HOXB7 were reported in the formation and progression of other cancers. Under these conditions, this study aimed to not only evaluate the expression of this gene in a series of 29 pancreatic ductal adenocarcinomas, 6 metastatic tissues and 24 peritumoral tissues, comparing them to normal tissues, but also examined the effect of its inhibition on the expression profile of the cells mentioned. The analysis of gene expression showed the hyper-regulation of HOXB7 gene transcript in the tumor tissues, confirming the results observed in cell lineages MIA PaCa-2, BxPC-3 and Capan-1. The inhibition performed with RNA interference promoted the modulation of different biological processes in all three cell lines investigated, as well as the induction of apoptosis and decreased in proliferation of the MIA PaCa-2 cells. In this context, the homeobox investigated in this study represents another component associated with the extensive network of molecules involved in…

Advisors/Committee Members: Giorgi, Ricardo Rodrigues.

Subjects/Keywords: Adenocarcinoma ductal do pâncreas; Expressão gênica; Gene expression; Gene HOXB7; Genes homeobox; Homeobox genes; HOXB7 gene; Interferência de RNA; Pancreatic ductal adenocarcinoma; RNA interference

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Chile, T. (2013). Análise funcional e expressão do gene homeobox HOXB7 em adenocarcinomas pancreáticos ductais. (Doctoral Dissertation). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/5/5135/tde-10052013-113753/ ;

Chicago Manual of Style (16^th Edition):

Chile, Thais. “Análise funcional e expressão do gene homeobox HOXB7 em adenocarcinomas pancreáticos ductais.” 2013. Doctoral Dissertation, University of São Paulo. Accessed January 15, 2021. http://www.teses.usp.br/teses/disponiveis/5/5135/tde-10052013-113753/ ;.

MLA Handbook (7^th Edition):

Chile, Thais. “Análise funcional e expressão do gene homeobox HOXB7 em adenocarcinomas pancreáticos ductais.” 2013. Web. 15 Jan 2021.

Vancouver:

Chile T. Análise funcional e expressão do gene homeobox HOXB7 em adenocarcinomas pancreáticos ductais. [Internet] [Doctoral dissertation]. University of São Paulo; 2013. [cited 2021 Jan 15]. Available from: http://www.teses.usp.br/teses/disponiveis/5/5135/tde-10052013-113753/ ;.

Council of Science Editors:

Chile T. Análise funcional e expressão do gene homeobox HOXB7 em adenocarcinomas pancreáticos ductais. [Doctoral Dissertation]. University of São Paulo; 2013. Available from: http://www.teses.usp.br/teses/disponiveis/5/5135/tde-10052013-113753/ ;

23. Campos, Marcia Sampaio. Expressão de genes homeobox em células de carcinoma epidermóide de boca estimuladas com EGF e TGF-beta.

Degree: PhD, Patologia Bucal, 2008, University of São Paulo

URL: http://www.teses.usp.br/teses/disponiveis/23/23141/tde-11042008-100919/ ;

►

Genes homeobox, vitais para muitos aspectos relacionados com crescimento e diferenciação celular, têm sido descritos desregulados em alguns cânceres. Seu papel na carcinogênese, principalmente de… (more)

▼

Genes homeobox, vitais para muitos aspectos relacionados com crescimento e diferenciação celular, têm sido descritos desregulados em alguns cânceres. Seu papel na carcinogênese, principalmente de carcinomas epidermóides de boca, permanence pouco claro e pobremente caracterizado. Desse modo, esse estudo objetivou avaliar, em cultura de células, o perfil de expressão de seis genes homeobox (ASH2L, HOXA7, HHEX, PKNOX1, PITX1, TGIF) selecionados dentre aqueles previamente identificados no Projeto Genoma Câncer de Cabeça e Pescoço (2001) sob estímulo de EGF e TGF-beta1. Para tal, linhagens celulares de carcinoma epidermóide de cabeça e pescoço primário (HN6) e metastático (HN31) e uma linhagem não-tumoral (HaCat) foram cultivadas sob condições-padrão. Após a confecção dos cDNAs de cada linhagem, por meio de RT-PCR, os transcritos foram amplificados e quantificados pela técnica de PCR em tempo real. Os dados foram normalizados com o gene HPRT e a quantificação relativa foi realizada seguindo o método do delta Ct. De acordo com os resultados foi possível verificar que o EGF produziu uma modulação variável da expressão dos genes avaliados em todas as linhagens celulares, enquanto que, em geral, o TGF-beta1 foi capaz de aumentar significantemente (ANOVA, p<0,05) a expressão dos transcritos de 5 genes homeobox (HOXA7, HHEX, PKNOX1, PITX1, TGIF). Particularmente transcritos dos genes PITX1 e TGIF foram signicantemente mais expressos nas linhagens tumorais (HN6 e HN31) frente à linhagem não-tumoral quando tratados com TGF-beta1. Desse modo, sugere-se que os genes homeobox estudados desempenhem diferentes funções na carcinoma epidermóide de boca, e que, especialmente PITX1 e TGIF atuem como oncogenes inibindo a resposta anti-proliferativa dependente de TGF-beta e levando a progressão tumoral.

Homeobox genes, vital to many aspects related with cellular growth and differentiation, had been described as deregulated in some cancers. Their role in carcinogenesis, mainly oral squamous cell carcinomas, remains unclear and poorly characterized. Thus, this study had the purpose to evaluate, in cell cultures, the expression profile of six homeobox genes (ASH2L, HOXA7, HHEX, PKNOX1, PITX1, TGIF) selected among genes previously identified in the Head and Neck Cancer Genoma Project (2001), under stimulation with EGF and TGF-beta1. Oral squamous cell carcinoma cell lines from primary tumour (HN6) and from methastasis (HN31), and a non-tumoral cell line (HaCat) were cultured under standard procedures. CDNAs were obtained by RT-PCR and the transcripts were amplified and quantified by real-time PCR. Data were normalized by HPRT gene and the relative quantification was made by the delta Ct method. According to the results, it was possible to observe that EGF produced a variable modulation of the analyzed genes, in all cell lines. Generally, TGF-beta1 was able to significantly increase (ANOVA, p<0,05) the expression of the transcripts of 5 homeobox genes (HOXA7, HHEX, PKNOX1, PITX1, TGIF). Transcripts of PITX1 and TGIF genes were particularly…

Advisors/Committee Members: Nunes, Fabio Daumas.

Subjects/Keywords: Carcinoma epidermóide de boca; Cell lines; EGF; EGF; Genes Homeobox; Homeobox genes; Linhagens celulares; Oral squamous cell carcinoma; PCR quantitativo; qPCR; TGF-beta; TGF-beta

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Campos, M. S. (2008). Expressão de genes homeobox em células de carcinoma epidermóide de boca estimuladas com EGF e TGF-beta. (Doctoral Dissertation). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/23/23141/tde-11042008-100919/ ;

Chicago Manual of Style (16^th Edition):

Campos, Marcia Sampaio. “Expressão de genes homeobox em células de carcinoma epidermóide de boca estimuladas com EGF e TGF-beta.” 2008. Doctoral Dissertation, University of São Paulo. Accessed January 15, 2021. http://www.teses.usp.br/teses/disponiveis/23/23141/tde-11042008-100919/ ;.

MLA Handbook (7^th Edition):

Campos, Marcia Sampaio. “Expressão de genes homeobox em células de carcinoma epidermóide de boca estimuladas com EGF e TGF-beta.” 2008. Web. 15 Jan 2021.

Vancouver:

Campos MS. Expressão de genes homeobox em células de carcinoma epidermóide de boca estimuladas com EGF e TGF-beta. [Internet] [Doctoral dissertation]. University of São Paulo; 2008. [cited 2021 Jan 15]. Available from: http://www.teses.usp.br/teses/disponiveis/23/23141/tde-11042008-100919/ ;.

Council of Science Editors:

Campos MS. Expressão de genes homeobox em células de carcinoma epidermóide de boca estimuladas com EGF e TGF-beta. [Doctoral Dissertation]. University of São Paulo; 2008. Available from: http://www.teses.usp.br/teses/disponiveis/23/23141/tde-11042008-100919/ ;

24. Lindsey, J. Suzanne. Characterization and hormonal regulation of the PEM homeobox gene.

Degree: PhD, 1996, Oregon Health Sciences University

URL: doi:10.6083/M4G73BXZ ; http://digitalcommons.ohsu.edu/etd/2713

Subjects/Keywords: Genes, Homeobox; Spermatogenesis; Testosterone; Gene Expression

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Lindsey, J. S. (1996). Characterization and hormonal regulation of the PEM homeobox gene. (Doctoral Dissertation). Oregon Health Sciences University. Retrieved from doi:10.6083/M4G73BXZ ; http://digitalcommons.ohsu.edu/etd/2713

Chicago Manual of Style (16^th Edition):

Lindsey, J Suzanne. “Characterization and hormonal regulation of the PEM homeobox gene.” 1996. Doctoral Dissertation, Oregon Health Sciences University. Accessed January 15, 2021. doi:10.6083/M4G73BXZ ; http://digitalcommons.ohsu.edu/etd/2713.

MLA Handbook (7^th Edition):

Lindsey, J Suzanne. “Characterization and hormonal regulation of the PEM homeobox gene.” 1996. Web. 15 Jan 2021.

Vancouver:

Lindsey JS. Characterization and hormonal regulation of the PEM homeobox gene. [Internet] [Doctoral dissertation]. Oregon Health Sciences University; 1996. [cited 2021 Jan 15]. Available from: doi:10.6083/M4G73BXZ ; http://digitalcommons.ohsu.edu/etd/2713.

Council of Science Editors:

Lindsey JS. Characterization and hormonal regulation of the PEM homeobox gene. [Doctoral Dissertation]. Oregon Health Sciences University; 1996. Available from: doi:10.6083/M4G73BXZ ; http://digitalcommons.ohsu.edu/etd/2713

University of Hong Kong

25. 張君樂. Analysis of lacZ gene expression patterns of a Hoxb3[lacZ] mouse mutant during early development.

Degree: 2005, University of Hong Kong

URL: http://hdl.handle.net/10722/131227

Subjects/Keywords: Mice - Genetics.; Gene expression.; Homeobox genes.

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

張君樂.. (2005). Analysis of lacZ gene expression patterns of a Hoxb3[lacZ] mouse mutant during early development. (Thesis). University of Hong Kong. Retrieved from http://hdl.handle.net/10722/131227

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

張君樂.. “Analysis of lacZ gene expression patterns of a Hoxb3[lacZ] mouse mutant during early development.” 2005. Thesis, University of Hong Kong. Accessed January 15, 2021. http://hdl.handle.net/10722/131227.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

張君樂.. “Analysis of lacZ gene expression patterns of a Hoxb3[lacZ] mouse mutant during early development.” 2005. Web. 15 Jan 2021.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete

Vancouver:

張君樂.. Analysis of lacZ gene expression patterns of a Hoxb3[lacZ] mouse mutant during early development. [Internet] [Thesis]. University of Hong Kong; 2005. [cited 2021 Jan 15]. Available from: http://hdl.handle.net/10722/131227.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

張君樂.. Analysis of lacZ gene expression patterns of a Hoxb3[lacZ] mouse mutant during early development. [Thesis]. University of Hong Kong; 2005. Available from: http://hdl.handle.net/10722/131227

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation

University of Utah

26. Makki, Nadja. Role of hoxa1 in mammalian hindbrain, inner ear and neural crest development.

Degree: PhD, Human Genetics;, 2010, University of Utah

URL: http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/1757/rec/999

► Homeobox transcription factors belong to a family of proteins involved in an array of developmental processes, the most important being specification of the anteriorposterior axis… (more)

Subjects/Keywords: Hoxa1; Mammalian; Hindbrain; Inner ear; Neural crest; Development; Rhombencephalon; Homeobox transcription factors; Hox genes

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Makki, N. (2010). Role of hoxa1 in mammalian hindbrain, inner ear and neural crest development. (Doctoral Dissertation). University of Utah. Retrieved from http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/1757/rec/999

Chicago Manual of Style (16^th Edition):

Makki, Nadja. “Role of hoxa1 in mammalian hindbrain, inner ear and neural crest development.” 2010. Doctoral Dissertation, University of Utah. Accessed January 15, 2021. http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/1757/rec/999.

MLA Handbook (7^th Edition):

Makki, Nadja. “Role of hoxa1 in mammalian hindbrain, inner ear and neural crest development.” 2010. Web. 15 Jan 2021.

Vancouver:

Makki N. Role of hoxa1 in mammalian hindbrain, inner ear and neural crest development. [Internet] [Doctoral dissertation]. University of Utah; 2010. [cited 2021 Jan 15]. Available from: http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/1757/rec/999.

Council of Science Editors:

Makki N. Role of hoxa1 in mammalian hindbrain, inner ear and neural crest development. [Doctoral Dissertation]. University of Utah; 2010. Available from: http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/1757/rec/999

Kyoto University / 京都大学

27. Guo, Long. Functional investigation of a non-coding variant associated with adolescent idiopathic scoliosis in zebrafish: elevated expression of the ladybird homeobox gene causes body axis deformation : ゼブラフィッシュを用いた思春期特発性脊柱側弯症に関連するノンコーディングバリアントの機能解析： ladybird homeobox遺伝子の発現亢進は体軸変形を誘導する.

Degree: 博士(医学), 2016, Kyoto University / 京都大学

URL: http://hdl.handle.net/2433/215453 ; http://dx.doi.org/10.14989/doctor.k19627

Final publication is available at http://www.plosgenetics.org/article/related/info%3Adoi%2F10.1371%2Fjournal.pgen.1005802

新制・課程博士

甲第19627号

医博第4134号

Subjects/Keywords: scoliosis; convergent extension; zebrafish; ladybird homeobox genes; non-canonical Wnt/PCP signaling

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Guo, L. (2016). Functional investigation of a non-coding variant associated with adolescent idiopathic scoliosis in zebrafish: elevated expression of the ladybird homeobox gene causes body axis deformation : ゼブラフィッシュを用いた思春期特発性脊柱側弯症に関連するノンコーディングバリアントの機能解析： ladybird homeobox遺伝子の発現亢進は体軸変形を誘導する. (Thesis). Kyoto University / 京都大学. Retrieved from http://hdl.handle.net/2433/215453 ; http://dx.doi.org/10.14989/doctor.k19627

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Guo, Long. “Functional investigation of a non-coding variant associated with adolescent idiopathic scoliosis in zebrafish: elevated expression of the ladybird homeobox gene causes body axis deformation : ゼブラフィッシュを用いた思春期特発性脊柱側弯症に関連するノンコーディングバリアントの機能解析： ladybird homeobox遺伝子の発現亢進は体軸変形を誘導する.” 2016. Thesis, Kyoto University / 京都大学. Accessed January 15, 2021. http://hdl.handle.net/2433/215453 ; http://dx.doi.org/10.14989/doctor.k19627.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Guo, Long. “Functional investigation of a non-coding variant associated with adolescent idiopathic scoliosis in zebrafish: elevated expression of the ladybird homeobox gene causes body axis deformation : ゼブラフィッシュを用いた思春期特発性脊柱側弯症に関連するノンコーディングバリアントの機能解析： ladybird homeobox遺伝子の発現亢進は体軸変形を誘導する.” 2016. Web. 15 Jan 2021.

Vancouver:

Guo L. Functional investigation of a non-coding variant associated with adolescent idiopathic scoliosis in zebrafish: elevated expression of the ladybird homeobox gene causes body axis deformation : ゼブラフィッシュを用いた思春期特発性脊柱側弯症に関連するノンコーディングバリアントの機能解析： ladybird homeobox遺伝子の発現亢進は体軸変形を誘導する. [Internet] [Thesis]. Kyoto University / 京都大学; 2016. [cited 2021 Jan 15]. Available from: http://hdl.handle.net/2433/215453 ; http://dx.doi.org/10.14989/doctor.k19627.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Guo L. Functional investigation of a non-coding variant associated with adolescent idiopathic scoliosis in zebrafish: elevated expression of the ladybird homeobox gene causes body axis deformation : ゼブラフィッシュを用いた思春期特発性脊柱側弯症に関連するノンコーディングバリアントの機能解析： ladybird homeobox遺伝子の発現亢進は体軸変形を誘導する. [Thesis]. Kyoto University / 京都大学; 2016. Available from: http://hdl.handle.net/2433/215453 ; http://dx.doi.org/10.14989/doctor.k19627

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

East Carolina University

28. Conaty, Lucy D. The effects of sodium butyrate on Hox gene expression in a human colorectal adenocarcinoma cell line, HT29.

Degree: MS, Biology: Molecular Biology and Biotechnology, 2013, East Carolina University

URL: http://hdl.handle.net/10342/4192

► Hox genes are a subgroup of the large family of homeobox containing genes, known to pattern anterior/posterior and proximal/distal axes during embryonic development. More recently… (more)

▼ Hox genes are a subgroup of the large family of homeobox containing genes, known to pattern anterior/posterior and proximal/distal axes during embryonic development. More recently Hox gene research has focused on the role of these genes during carcinogenesis. We studied the pattern of Hox gene expression in a human colorectal adenocarcinoma cell line, HT29, in response to treatment with a histone deacetylase inhibitor, sodium butyrate. Sodium butyrate treatment has been previously described to differentiate HT29 cells. The cells acquire differentiated characteristics after a seven-day treatment period with 5 mM sodium butyrate. These features include increased microvilli concentrations, tight junctions, and the formation of apical and basolateral domains. Our research aimed to study the role of Hox genes in colorectal cancer by analyzing their expression in both proliferative and growth-inhibited HT29 cells. The first phase of our research was to determine the pattern of expression for all 39 characterized human Hox genes using RT-PCR in order to select genes of interest that are differentially between proliferating and differentiated HT29 cells. The second was to verify the differential expression of these genes with qRT-PCR and Western blot. It was observed that most genes of cluster D were expressed in untreated but not treated HT29 cells. More specifically, D8 and D9 were the only two genes of this cluster with a differential pattern of expression than the other genes of their paralog groups. We hypothesized that D8 and D9 are responsible for maintaining the proliferative, undifferentiated state of the HT29 cells. Using qRT-PCR analysis, D8 was shown to be up-regulated in untreated HT29 cells in comparison to treated HT29 when normalized to housekeeping genes. However, D9 was shown to be down-regulated in untreated HT29 in comparison to treated HT29 when normalized to housekeeping genes. The Western blot for Hox D9 reflected the findings of RT-PCR but not qRT-PCR. Protein expression was present in untreated HT29 cell lysates, but not the sodium butyrate treated lysates. D8 showed no protein expression in either untreated or treated cell lysates. The effects of sodium butyrate treatment on HT29 cell proliferation and differentiation was assessed using growth curves and ultrastructural analysis by transmission electron microscopy. It was observed that when cells are seeded at a low density (9.6 x 10â�´) and recorded for seven days, sodium butyrate treatment effectively inhibited cellular proliferation. Electron micrographs showed that NaBT treated HT29 cells exhibited potential apical domains, increased concentrations of microvilli, tight junctions and approximately double the number of desmosomes at intercellular junctions. In addition, some of the treated cells exhibited the formation of mucin granules, specific to the phenotype of epithelial goblet cells. Advisors/Committee Members: Scemama, Jean-Luc (advisor).

Subjects/Keywords: Biology, Molecular; Molecular biology; Gene expression; Homeobox genes; Histones; Adenocarcinoma; Colon (Anatomy) – Cancer; Rectum – Cancer

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Conaty, L. D. (2013). The effects of sodium butyrate on Hox gene expression in a human colorectal adenocarcinoma cell line, HT29. (Masters Thesis). East Carolina University. Retrieved from http://hdl.handle.net/10342/4192

Chicago Manual of Style (16^th Edition):

Conaty, Lucy D. “The effects of sodium butyrate on Hox gene expression in a human colorectal adenocarcinoma cell line, HT29.” 2013. Masters Thesis, East Carolina University. Accessed January 15, 2021. http://hdl.handle.net/10342/4192.

MLA Handbook (7^th Edition):

Conaty, Lucy D. “The effects of sodium butyrate on Hox gene expression in a human colorectal adenocarcinoma cell line, HT29.” 2013. Web. 15 Jan 2021.

Vancouver:

Conaty LD. The effects of sodium butyrate on Hox gene expression in a human colorectal adenocarcinoma cell line, HT29. [Internet] [Masters thesis]. East Carolina University; 2013. [cited 2021 Jan 15]. Available from: http://hdl.handle.net/10342/4192.

Council of Science Editors:

Conaty LD. The effects of sodium butyrate on Hox gene expression in a human colorectal adenocarcinoma cell line, HT29. [Masters Thesis]. East Carolina University; 2013. Available from: http://hdl.handle.net/10342/4192

University of Missouri – Columbia

29. Burroughs-Garcia, Jessica, 1980-. Analysis of Gbx genes during neural development.

Degree: 2013, University of Missouri – Columbia

URL: https://doi.org/10.32469/10355/40233

► [ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] The understanding of how transcription factors regulate neural patterning in the anterior hindbrain, and how… (more)

▼ [ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] The understanding of how transcription factors regulate neural patterning in the anterior hindbrain, and how the assembly of specific neuronal circuits controlling motor behavior in the developing spinal cord are important concerns in the field of developmental biology. In this dissertation we used two animal models, mouse and zebrafish, to study how gastrulation-brain homeobox (Gbx) class transcription factors (Gbx1 and Gbx2), affect the formation of sensorimotor circuits in mice and the development of anterior hindbrain in zebrafish. We use gene inactivation to study the role of Gbx1 and gbx2 during mouse and zebrafish embryogenesis. Gbx1 mutant (Gbx1-/-) mice develop a severe defect in motor coordination specifically affecting hindlimb gait. Loss of Gbx1 also resulted in an aberrant projection of the Ia proprioceptive sensory fiber in the ventral horn of the developing spinal cord. In addition, we show that Gbx1-/- embryos exhibit a reduction of Islet 1+ (ISL1) ventral motor neurons beginning at E14.5. In a parallel study, we investigated the role of gbx2 in the development of the anterior hindbrain in zebrafish embryos (Burroughs-Garcia et al., 2011). Gbx2 is widely known in mice and other vertebrates for it role positioning the mid hindbrain boundary. Despite many studies in mice showing the need of Gbx2 for normal hindbrain development, only few studies have focused on this role for Gbx2 in other vertebrates. Since the expression of Gbx2 in anterior hindbrain is conserved among vertebrate, we investigated whether the role of Gbx2 is functionally conserved during anterior hindbrain development in zebrafish. Loss-of-function studies using antisense morpholino show that gbx2 mutant embryos exhibit similar developmental defects as seen in hypomorphic mice (Waters and Lewandoski, 2006). We showed that deletion of gbx2 results in a truncation of the anterior hindbrain region between rhombomere (r)1 and r3 (Burroughs-Garcia et al., 2011). Furthermore there is an abnormal clustering of nV cell bodies arising from r2 and r3. These phenotypes can be rescued by injecting mouse Gbx2 mRNA (Buckley et al., 2013). This dissertation provides the first functional analysis of Gbx1 during mouse embryonic development. Additionally, our results provide evidence that gbx2/Gbx2 has shared an evolutionarily conserved role during the development of the anterior hindbrain in zebrafish embryos. Advisors/Committee Members: Waters, Samuel T. (advisor).

Subjects/Keywords: Transcription factors – Animal models; Homeobox genes – Animal models; Developmental neurobiology – Animal models

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Burroughs-Garcia, Jessica, 1. (2013). Analysis of Gbx genes during neural development. (Thesis). University of Missouri – Columbia. Retrieved from https://doi.org/10.32469/10355/40233

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Burroughs-Garcia, Jessica, 1980-. “Analysis of Gbx genes during neural development.” 2013. Thesis, University of Missouri – Columbia. Accessed January 15, 2021. https://doi.org/10.32469/10355/40233.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Burroughs-Garcia, Jessica, 1980-. “Analysis of Gbx genes during neural development.” 2013. Web. 15 Jan 2021.

Vancouver:

Burroughs-Garcia, Jessica 1. Analysis of Gbx genes during neural development. [Internet] [Thesis]. University of Missouri – Columbia; 2013. [cited 2021 Jan 15]. Available from: https://doi.org/10.32469/10355/40233.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Burroughs-Garcia, Jessica 1. Analysis of Gbx genes during neural development. [Thesis]. University of Missouri – Columbia; 2013. Available from: https://doi.org/10.32469/10355/40233

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Hong Kong

30. 王兴安. Cross talk between Hox genes and sonic hedgehog signaling during mousehindbrain neurogenesis.

Degree: 2010, University of Hong Kong

URL: http://hdl.handle.net/10722/159170

Subjects/Keywords: Homeobox genes.; Cellular signal transduction.; Neurogenetics.

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

王兴安. (2010). Cross talk between Hox genes and sonic hedgehog signaling during mousehindbrain neurogenesis. (Thesis). University of Hong Kong. Retrieved from http://hdl.handle.net/10722/159170

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

王兴安. “Cross talk between Hox genes and sonic hedgehog signaling during mousehindbrain neurogenesis.” 2010. Thesis, University of Hong Kong. Accessed January 15, 2021. http://hdl.handle.net/10722/159170.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

王兴安. “Cross talk between Hox genes and sonic hedgehog signaling during mousehindbrain neurogenesis.” 2010. Web. 15 Jan 2021.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete

Vancouver:

王兴安. Cross talk between Hox genes and sonic hedgehog signaling during mousehindbrain neurogenesis. [Internet] [Thesis]. University of Hong Kong; 2010. [cited 2021 Jan 15]. Available from: http://hdl.handle.net/10722/159170.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

王兴安. Cross talk between Hox genes and sonic hedgehog signaling during mousehindbrain neurogenesis. [Thesis]. University of Hong Kong; 2010. Available from: http://hdl.handle.net/10722/159170

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation

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Open Access Theses and Dissertations