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1.
Maisel, Priscila de Oliveira Pinto.
Os caminhos da cobra na po?tica da artista Bernadete Andrade.
Degree: 2014, Universidade Federal do Amazonas
URL: http://tede.ufam.edu.br/handle/tede/4341
► A artista pl?stica amazonense Bernadete Andrade (1953-2007) traz em seu conjunto de obras refer?ncias de seu meio cultural. Nesta pesquisa buscamos compreender as rela??es intr?nsecas…
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▼ A artista pl?stica amazonense Bernadete Andrade (1953-2007) traz em seu conjunto de obras refer?ncias de seu meio cultural. Nesta pesquisa buscamos compreender as rela??es intr?nsecas e extr?nsecas ocorridas no processo de cria??o em artes, discutindo as inter-rela??es culturais e os elementos visuais presentes na sua obra. Nosso objetivo ? percorrer parte deste processo de cria??o para interpretarmos as imagens da serpente encontradas em seus desenhos, pinturas e interven??es art?sticas, no per?odo de 1989 a 2006. Quanto aos procedimentos metodol?gicos e t?cnicos, recorremos ? Cr?tica Gen?tica para a an?lise de documentos de processo, tais como esbo?os, rascunhos, textos, cadernos de estudo, entre outros. Utilizamo-nos, tamb?m, da pesquisa bibliogr?fica para embasamento do contexto cultural da artista. Seguimos um m?todo multidisciplinar de estudo e estabelecemos uma rede complexa, o que justifica nossa abordagem semi?tico-sist?mica. Observamos, assim, as rela??es intersemi?ticas constru?das na semiosfera da artista, que envolvem aspectos da cultura amaz?nica e universal. E percebemos o caminho percorrido por ela na elabora??o e amadurecimento de seu estilo e escolhas tem?ticas, fazendo liga??o estrutural e conceitual entre suas obras, a partir da imagem da cobra, no decorrer de dezessete anos de sua carreira. Nossa hip?tese, portanto, ? de que a linha e a cobra foram utilizadas pela artista como met?foras da cria??o.
The Amazonian artist Bernadete Andrade (1953-2007) expresses in her body of work references of her culture. In this research we seek to understand the intrinsic and extrinsic relations in the creative process of art, discussing the cultural interrelations and visual elements expressed in her work. Our objective in this study is to analyze this creation process to interpret the images of the snake found in her drawings, paintings and artistic interventions, from 1989 to 2006. By utilizing methodological and technical principals of Genetic Criticism we seek to analyze and document the creative process involved in the creation of her work by analyzing records such as sketches, drafts, texts and draft books. We are also utilizing bibliographic research as the basis for the cultural context of the artist by following a multidisciplinary methodology and established a complex network, which justifies our semiotic systems approach. Thus observing the relationships built in inter-semiotic Semiosphere of the artist herself and the involvement of uniquely Amazonian and universal concepts of cultural influence on the artistic creative process. Through this analysis we see the path of Bernadete Andrade in the development and maturation of her style and thematic choices, thus making definitive structural and conceptual links between the thematic of her works utilizing the image of the snake over the course of seventeen years of her career. Our hypothesis is therefore that the line itself and the snake were used as metaphors for the artist's concept of creation.
N?o Informada
Advisors/Committee Members: Barros, Rosemara Staub de, 017.617.848-11, http://lattes.cnpq.br/2680914238480876, Cirillo, Aparecido Jos?, Pinto, Marilina Concei??o Oliveira Bessa Serra.
Subjects/Keywords: Cr?tica gen?tica; Arte na Amaz?nia; Bernadete Andrade; Genetic criticism; Amazonian art; OUTROS
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APA (6th Edition):
Maisel, P. d. O. P. (2014). Os caminhos da cobra na po?tica da artista Bernadete Andrade. (Masters Thesis). Universidade Federal do Amazonas. Retrieved from http://tede.ufam.edu.br/handle/tede/4341
Chicago Manual of Style (16th Edition):
Maisel, Priscila de Oliveira Pinto. “Os caminhos da cobra na po?tica da artista Bernadete Andrade.” 2014. Masters Thesis, Universidade Federal do Amazonas. Accessed March 06, 2021.
http://tede.ufam.edu.br/handle/tede/4341.
MLA Handbook (7th Edition):
Maisel, Priscila de Oliveira Pinto. “Os caminhos da cobra na po?tica da artista Bernadete Andrade.” 2014. Web. 06 Mar 2021.
Vancouver:
Maisel PdOP. Os caminhos da cobra na po?tica da artista Bernadete Andrade. [Internet] [Masters thesis]. Universidade Federal do Amazonas; 2014. [cited 2021 Mar 06].
Available from: http://tede.ufam.edu.br/handle/tede/4341.
Council of Science Editors:
Maisel PdOP. Os caminhos da cobra na po?tica da artista Bernadete Andrade. [Masters Thesis]. Universidade Federal do Amazonas; 2014. Available from: http://tede.ufam.edu.br/handle/tede/4341

Universidade Nova
2.
CHINJENGUE, Nataniel Paulino.
Fasciola hepatica: diversidade gen�tica e avalia��o de SNPs associados a resist�ncia ao albendazol em Portugal e Brasil.
Degree: 2016, Universidade Nova
URL: https://www.rcaap.pt/detail.jsp?id=oai:run.unl.pt:10362/20070
► Nos �ltimos anos, em muitos pa�ses, incluindo Portugal, a fasciolose tem vindo a ser considerada uma doen�a emergente, resultando num problema de sa�de humana e…
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▼ Nos �ltimos anos, em muitos pa�ses, incluindo Portugal, a fasciolose tem vindo a ser considerada uma doen�a emergente, resultando num problema de sa�de humana e animal, e com elevado impacte econ�mico. O conhecimento da estrutura gen�tica de popula��es de Fasciola hepatica � essencial quando se avalia o potencial de desenvolvimento e extens�o da resist�ncia aos anti-helm�nticos, tais como f�rmacos triclorobendazol e albendazol. A esp�cie F. hepatica pode ser encontrada em todos os continentes, exceto a Ant�rtida, enquanto que F. gigantica se encontra apenas na �frica e na �sia. Ambas as esp�cies de Fasciola utilizam como hospedeiros intermedi�rios moluscos de �gua doce da fam�lia Lymnaeidae. Utilizou-se uma amostra com um total de 94 vermes. Oitenta e sete vermes adultos de F. hepatica da cole��o do Departamento de Helmintologia M�dica do IHMT, fixados em etanol a 70% e armazenados a -20 �C, obtidos entre 2009 e 2010 em matadouros de Portugal e provenientes de
diversas regi�es do pa�s. Sete vermes tinham sido recolhidos no Brasil em 2015. Extraiu-se o DNA gen�mico atrav�s do protocolo de CTAB. Avaliaram-se tr�s marcadores nucleares: ITS1, para identifica��o da esp�cie, o gene ribossomal 28S e o gene para TubB3, que � um marcador candidato de resist�ncia aos f�rmacos. Avaliou-se tamb�m um marcador mitocondrial: citocromo c oxidase I. Os marcadores foram amplificados por PCR e sequenciados. No caso de 28S e de TubB3, SNPs de interesse foram genotipados com PCR espec�fico desenvolvido no �mbito deste trabalho, e no qual se testou a efici�ncia de desemparelhamentos em bases na 2� e na 3� posi��es antes do extremo 3?. Redes filogen�ticas foram geradas, para alinhamentos de sequ�ncias com bases amb�guas ou heterozig�ticas, no programa SplitsTree4, utilizando o algoritmo NeighborNet e as dist�ncias calculadas atrav�s do modelo Kimura-2- parameter. A regi�o ITS1 permitiu identificar as amostras como F. hepatica e mostrou ser bastante conservada. A
regi�o 28S mostrou heterozigotia na posi��o 115, que separa duas linhagens encontradas no leste Europeu, em todas as amostras Portuguesas e Brasileiras, sugerindo que esteja a ocorrer sele��o de heterozigoto ou reprodu��o partenog�nica. As regi�es COI e TubB3 apresentaram diversidade intra-populacional em Portugal e no Brasil e em rela��o a outras regi�es, assim como heterozigotia em v�rias posi��es, e poder�o ser usadas em estudos populacionais alargados desta esp�cie nos dois pa�ses. Contudo, a altera��o n�o sin�nima na posi��o 311 de TubB3 n�o foi detetada nas amostras estudadas, sugerindo que este gene n�o est� envolvido em resist�ncia a f�rmacos em F. hepatica, pelo menos em Portugal ou no Brasil. O PCR espec�fico para alelos mostrou ser uma alternativa � sequencia��o para genotipagem de SNPs espec�ficos num n�mero grande de amostras, particularmente em estudos populacionais e na pesquisa de marcadores de resist�ncia a f�rmacos.
In recent years, in many countries, including Portugal, fascioliasis has been considered an emerging disease, being a human and animal health…
Advisors/Committee Members: MAUR�CIO, Isabel, CALADO, Manuela.
Subjects/Keywords: Parasitologia m�dica; F�gado patologia; Gen�tica; Portugal; Brasil
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
CHINJENGUE, N. P. (2016). Fasciola hepatica: diversidade gen�tica e avalia��o de SNPs associados a resist�ncia ao albendazol em Portugal e Brasil. (Thesis). Universidade Nova. Retrieved from https://www.rcaap.pt/detail.jsp?id=oai:run.unl.pt:10362/20070
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
CHINJENGUE, Nataniel Paulino. “Fasciola hepatica: diversidade gen�tica e avalia��o de SNPs associados a resist�ncia ao albendazol em Portugal e Brasil.” 2016. Thesis, Universidade Nova. Accessed March 06, 2021.
https://www.rcaap.pt/detail.jsp?id=oai:run.unl.pt:10362/20070.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
CHINJENGUE, Nataniel Paulino. “Fasciola hepatica: diversidade gen�tica e avalia��o de SNPs associados a resist�ncia ao albendazol em Portugal e Brasil.” 2016. Web. 06 Mar 2021.
Vancouver:
CHINJENGUE NP. Fasciola hepatica: diversidade gen�tica e avalia��o de SNPs associados a resist�ncia ao albendazol em Portugal e Brasil. [Internet] [Thesis]. Universidade Nova; 2016. [cited 2021 Mar 06].
Available from: https://www.rcaap.pt/detail.jsp?id=oai:run.unl.pt:10362/20070.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
CHINJENGUE NP. Fasciola hepatica: diversidade gen�tica e avalia��o de SNPs associados a resist�ncia ao albendazol em Portugal e Brasil. [Thesis]. Universidade Nova; 2016. Available from: https://www.rcaap.pt/detail.jsp?id=oai:run.unl.pt:10362/20070
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
3.
Leal, Viviann Greicy Batista.
Determina??o de desempenho zoot?cnico e morfometria de linhagens de tambaqui (Colossoma macropomum) melhorados geneticamente.
Degree: 2019, Universidade Federal do Amazonas
URL: https://tede.ufam.edu.br/handle/tede/7499
► O melhoramento gen?tico do tambaqui Colossoma macropomum visa impulsionar a produ??o desta esp?cie no pa?s, pois foi desenvolvido para aumentar a taxa de crescimento deste…
(more)
▼ O melhoramento gen?tico do tambaqui Colossoma macropomum visa impulsionar a produ??o desta esp?cie no pa?s, pois foi desenvolvido para aumentar a taxa de crescimento deste peixe. O objetivo deste trabalho foi avaliar o desempenho zoot?cnico e caracter?sticas morfom?tricas de 3 linhagens geneticamente melhoradas de tambaqui em rela??o a peixes n?o melhorados e analisar o impacto do melhoramento gen?tico no tempo de 122 dias de cria??o para a produ??o de tambaqui curumim com peso m?dio de 500g. Os juvenis utilizados para este estudo s?o oriundos do acasalamento de 6 reprodutores (3 machos e 3 f?meas) do Programa de Melhoramento Gen?tico AquaBrasil que formaram os tratamentos (linhagens A, B e C) para o grupo controle foram utilizados juvenis oriundos de um casal de reprodutores n?o melhorados. Foram identificados, por meio de microchips, 160 juvenis sendo 40 peixes de cada linhagem melhorada e 40 peixes n?o melhorados (controle). Foram alojados em um viveiro escavado com ?rea de 600 m?, com densidade de 0,26 peixes. m?. Os juvenis iniciaram o experimento com peso m?dio de 58, 08 ? 24, 44g e comprimento total de 17, 73 ? 1, 72 cm. Foram alimentados com ra??o comercial com n?veis de prote?na bruta que decresceram a cada m?s: 36, 32 e 28%, sendo fornecida duas vezes ao dia (8:00 e 17:00 horas), a taxa alimentar variou de 7-2% da biomassa. Foram realizadas biometrias mensais para a obten??o de peso e medidas corporais como comprimento total, padr?o, comprimento da cabe?a, altura e largura do corpo. Os dados foram submetidos a an?lise de vari?ncia e teste de Tukey (5% ). A taxa de sobreviv?ncia foi de 100%. A linhagem B apresentou a menor m?dia para ganho de peso (808, 70g) diferenciando-se das linhagens A (873,73g), C (886,41g) e controle (875,45g), estas n?o diferiram entre si. Os peixes da linhagem C apresentaram a maior m?dia para a taxa de crescimento espec?fico (2,52%) demonstrando um maior crescimento. Para as caracter?sticas morfom?tricas a linhagem B obteve a menor conforma??o corporal, por?m apresentou diferen?a para a raz?o morfom?trica largura do corpo/comprimento padr?o, entretanto foi igual ? linhagem C, a qual apresentou a melhor conforma??o corporal e a maior rela??o entre o comprimento da cabe?a e comprimento padr?o. Mesmo com essas diferen?as as 3 linhagens de tambaqui melhoradas, assim como os peixes n?o melhorados superaram o peso estabelecido de 500g em 122 dias de cria??o. Por?m, para a continua??o do Programa de Melhoramento Gen?tico de Tambaqui no Amazonas, sugere-se a utiliza??o dos peixes da linhagem C que demonstraram melhores resultados entre as linhagens melhoradas
The genetic improvement of tambaqui Colossoma macropomum aims to boost the production of this species in the country, as it was developed to increase the growth rate of this fish. The objective of this work was to evaluate the zootechnical performance and morphometric characteristics of 3 genetically improved tambaqui strains in relation to unimproved fish and to analyze the impact of genetic improvement on the 122 days of breeding…
Advisors/Committee Members: Lima, Jackson Pantoja, 663.591.712-87, http://lattes.cnpq.br/1227404149595373, Almeida, Fernanda Ferreira Loureiro de, http://lattes.cnpq.br/1190817093943782, Gon?alves, Ligia Uribe, http://lattes.cnpq.br/7519034481265162, Mattos, Bruno Olivetti de, http://lattes.cnpq.br/3660814382793156, [email protected].
Subjects/Keywords: Tambaqui (Peixe) - Cria??o; Peixes - Gen?tica; Peixes - Amazonas (Estado); CI?NCIAS BIOL?GICAS: GEN?TICA; Amazonas; Crescimento; Melhoramento Gen?tico; Piscicultura; Tambaqui-curumim
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Leal, V. G. B. (2019). Determina??o de desempenho zoot?cnico e morfometria de linhagens de tambaqui (Colossoma macropomum) melhorados geneticamente. (Masters Thesis). Universidade Federal do Amazonas. Retrieved from https://tede.ufam.edu.br/handle/tede/7499
Chicago Manual of Style (16th Edition):
Leal, Viviann Greicy Batista. “Determina??o de desempenho zoot?cnico e morfometria de linhagens de tambaqui (Colossoma macropomum) melhorados geneticamente.” 2019. Masters Thesis, Universidade Federal do Amazonas. Accessed March 06, 2021.
https://tede.ufam.edu.br/handle/tede/7499.
MLA Handbook (7th Edition):
Leal, Viviann Greicy Batista. “Determina??o de desempenho zoot?cnico e morfometria de linhagens de tambaqui (Colossoma macropomum) melhorados geneticamente.” 2019. Web. 06 Mar 2021.
Vancouver:
Leal VGB. Determina??o de desempenho zoot?cnico e morfometria de linhagens de tambaqui (Colossoma macropomum) melhorados geneticamente. [Internet] [Masters thesis]. Universidade Federal do Amazonas; 2019. [cited 2021 Mar 06].
Available from: https://tede.ufam.edu.br/handle/tede/7499.
Council of Science Editors:
Leal VGB. Determina??o de desempenho zoot?cnico e morfometria de linhagens de tambaqui (Colossoma macropomum) melhorados geneticamente. [Masters Thesis]. Universidade Federal do Amazonas; 2019. Available from: https://tede.ufam.edu.br/handle/tede/7499

Universidad de Cantabria
4.
Prieto Guti?rrez, Noelia.
Bio?tica y cuidado de las ?lceras por presi?n : perspectiva de las enfermeras hospitalarias de Cantabria.
Degree: M?ster en Gesti?n Integral e Investigaci?n de las Heridas Cr?nicas, 2015, Universidad de Cantabria
URL: http://hdl.handle.net/10902/6591
► Como objetivo principal nos planteamos explorar la percepci?n que existe en los profesionales de enfermer?a del ?rea hospitalaria del Servicio C?ntabro de Salud en relaci?n…
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▼ Como objetivo principal nos planteamos explorar la percepci?n que existe en los profesionales de enfermer?a del ?rea hospitalaria del Servicio C?ntabro de Salud en relaci?n a sus conocimientos y pr?ctica cl?nica habitual en materia de prevenci?n y cuidado de las ?lceras por presi?n y sus implicaciones ?ticas. La reflexi?n individualizada a trav?s de entrevistas semiestructuradas a informantes clave, permitir? conocer de forma m?s profunda las percepciones y valores del profesional de enfermer?a en su d?a a d?a ante este tipo de lesiones. Se establecer? por tanto, una perspectiva cualitativa con enfoque fenomenol?gico.
Advisors/Committee Members: Zabala Blanco, Jaime (advisor), Universidad de Cantabria (other).
Subjects/Keywords: Bio?tica
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APA ·
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MLA ·
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APA (6th Edition):
Prieto Guti?rrez, N. (2015). Bio?tica y cuidado de las ?lceras por presi?n : perspectiva de las enfermeras hospitalarias de Cantabria. (Masters Thesis). Universidad de Cantabria. Retrieved from http://hdl.handle.net/10902/6591
Chicago Manual of Style (16th Edition):
Prieto Guti?rrez, Noelia. “Bio?tica y cuidado de las ?lceras por presi?n : perspectiva de las enfermeras hospitalarias de Cantabria.” 2015. Masters Thesis, Universidad de Cantabria. Accessed March 06, 2021.
http://hdl.handle.net/10902/6591.
MLA Handbook (7th Edition):
Prieto Guti?rrez, Noelia. “Bio?tica y cuidado de las ?lceras por presi?n : perspectiva de las enfermeras hospitalarias de Cantabria.” 2015. Web. 06 Mar 2021.
Vancouver:
Prieto Guti?rrez N. Bio?tica y cuidado de las ?lceras por presi?n : perspectiva de las enfermeras hospitalarias de Cantabria. [Internet] [Masters thesis]. Universidad de Cantabria; 2015. [cited 2021 Mar 06].
Available from: http://hdl.handle.net/10902/6591.
Council of Science Editors:
Prieto Guti?rrez N. Bio?tica y cuidado de las ?lceras por presi?n : perspectiva de las enfermeras hospitalarias de Cantabria. [Masters Thesis]. Universidad de Cantabria; 2015. Available from: http://hdl.handle.net/10902/6591
5.
Mendes, Abra?o Caetano.
Propriedades gen?ricas de autofun??es e autovalores de operadores el?pticos na forma divergente em variedades Riemannianas.
Degree: 2020, Universidade Federal do Amazonas
URL: https://tede.ufam.edu.br/handle/tede/7732
► Neste trabalho, provamos propriedades gen?ricas de autovalores e autofun??es de fam?lias a dois e tr?s par?metros de operadores el?pticos na forma divergente em variedades Riemannianas…
(more)
▼ Neste trabalho, provamos propriedades gen?ricas de autovalores e autofun??es de fam?lias
a dois e tr?s par?metros de operadores el?pticos na forma divergente em variedades Riemannianas
compactas com bordo. Assumiremos as condi??es de fronteira de Dirichlet,
T-Neumann e T-Robin. As principais ferramentas que utilizamos foram desenvolvidas
por K. Uhlenbeck em [Generic Properties of Eigenfunctions, Amer. J. Math. 98 (1976)
1059-1078].
In this work, we prove generic properties of eigenvalues and eigenfunctions to two
and to three parameters families of the elliptic operators in the divergence form on
compact Riemannian manifolds with boundary. We assume the Dirichlet, T-Neumann
and T-Robin boundary conditions. The main tools that we used were developed by K.
Uhlenbeck in [Generic Properties of Eigenfunctions, Amer. J. Math. 98 (1976) 1059-
1078].
FAPEAM - Funda??o de Amparo ? Pesquisa do Estado do Amazonas
CAPES - Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior
Advisors/Committee Members: Marrocos, Marcus Ant?nio Mendon?a, http://lattes.cnpq.br/8619708073570281, Gomes, Jos? Nazareno Vieira, http://lattes.cnpq.br/5896951132632512, Tsonev, Dragomir Mitkov, http://lattes.cnpq.br/1236278525981498, Miyagaki, Ol?mpio Hiroshi, http://lattes.cnpq.br/2646698407526867.
Subjects/Keywords: Variedades Riemannianas; Operadores el?pticos; Condi??o de Dirichlet; Condi??o de T-Neumann; Condi??o de T-Robin; CI?NCIAS EXATAS E DA TERRA: MATEM?TICA; Operadores el?pticos; Propriedades gen?ricas; Condi??o de Dirichlet; Condi??o de T-Neumann; Condi??o de T-Robin
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Mendes, A. C. (2020). Propriedades gen?ricas de autofun??es e autovalores de operadores el?pticos na forma divergente em variedades Riemannianas. (Doctoral Dissertation). Universidade Federal do Amazonas. Retrieved from https://tede.ufam.edu.br/handle/tede/7732
Chicago Manual of Style (16th Edition):
Mendes, Abra?o Caetano. “Propriedades gen?ricas de autofun??es e autovalores de operadores el?pticos na forma divergente em variedades Riemannianas.” 2020. Doctoral Dissertation, Universidade Federal do Amazonas. Accessed March 06, 2021.
https://tede.ufam.edu.br/handle/tede/7732.
MLA Handbook (7th Edition):
Mendes, Abra?o Caetano. “Propriedades gen?ricas de autofun??es e autovalores de operadores el?pticos na forma divergente em variedades Riemannianas.” 2020. Web. 06 Mar 2021.
Vancouver:
Mendes AC. Propriedades gen?ricas de autofun??es e autovalores de operadores el?pticos na forma divergente em variedades Riemannianas. [Internet] [Doctoral dissertation]. Universidade Federal do Amazonas; 2020. [cited 2021 Mar 06].
Available from: https://tede.ufam.edu.br/handle/tede/7732.
Council of Science Editors:
Mendes AC. Propriedades gen?ricas de autofun??es e autovalores de operadores el?pticos na forma divergente em variedades Riemannianas. [Doctoral Dissertation]. Universidade Federal do Amazonas; 2020. Available from: https://tede.ufam.edu.br/handle/tede/7732
6.
Lima, Aline Ara?jo Patr?cio.
Diversidade gen?tica entre e dentro de popula??es de Astrocaryum acaule Mart. (ARECACEAE).
Degree: 2017, Universidade Federal do Amazonas
URL: https://tede.ufam.edu.br/handle/tede/8022
► Astrocaryum acaule Mart. (Arecaceae) possui frutos comest?veis, a semente da planta ? utilizada para a fabrica??o de bioj?ias e as folhas para extra??o de fibras.…
(more)
▼ Astrocaryum acaule Mart. (Arecaceae) possui frutos comest?veis, a semente da planta ? utilizada para a fabrica??o de bioj?ias e as folhas para extra??o de fibras. Com o caule subterr?neo, esta esp?cie tem sido visada no melhoramento interespec?fico com A. aculeatum para a redu??o do porte dessa importante fruteira da Amaz?nia. O objetivo deste estudo foi avaliar a diversidade gen?tica entre e dentro de popula??es de A. acaule por meio de marcadores AFLP. Foram estudadas tr?s popula??es localizadas na cidade de Manaus. Em cada popula??o foram coletadas aleatoriamente amostras foliares de 30 plantas. Tr?s combina??es de primers AFLP foram analisadas nas popula??es: E+ACA/M+CGC, E+AAC/M+CAC e E+AAC/M+CGA e estimada a porcentagem de locos polim?rficos. A partir dos dados bin?rios obtidos das genotipagens foi realizada an?lise de vari?ncia molecular, constru?do o dendrograma e verificado os padr?es gen?ticos de diferencia??o e subestrutura??o populacional. Dos 200 locos revelados, 198 (99%) foram polim?rficos. O dendrograma gerado com base no complemento aritm?tico da dist?ncia gen?tica de Jaccard e m?todo de agrupamento UPGMA das 90 subamostras de A. acaule revelou que os indiv?duos da popula??o do Tarum?-A?u se destacam como sendo geneticamente diferentes das outras duas popula??es, UFAM e Tup? e o dendrograma obtido com base na dist?ncia gen?tica de Nei confirmou esta informa??o. Os valores da heterozigosidade esperada (He) e o ?ndice de diversidade gen?tica de Shannon e Weaver (I) n?o apresentaram grandes varia??es entre as tr?s popula??es. Contudo, os maiores valores de He (0,2169) e I (0,3413) foram encontrados na popula??o Tarum?-A?u, indicando maior diversidade gen?tica dentro desta popula??o. O resultado da An?lise Molecular de Vari?ncia atribuiu 25,42% e 74,58% da varia??o entre e dentro das popula??es, respectivamente. Assim, planos de uso e conserva??o da esp?cie devem observar a variabilidade gen?tica encontrada nessas popula??es, visando garantir a conserva??o de seus recursos gen?ticos. Os marcadores moleculares do tipo AFLP revelam alto conte?do de informa??o gen?tica em A. acaule e podem ser utilizados para an?lises gen?ticas, visando obter informa??es para a sustentabilidade gen?tica e manejo da esp?cie. A distribui??o da diversidade gen?tica nas popula??es estudadas de A. acaule ? maior dentro das popula??es que entre elas, sendo necess?rio obter amostras representativas de cada um dos grupos geneticamente distintos para a conserva??o gen?tica das popula??es estudadas.
Astrocaryum acaule Mart. (Arecaceae) has edible fruits, the seed is used for the manufacture of bioj?ias, the leaves for fiber extraction. With the subterranean stem, this species can be targeted in the interspecific improvement with A. aculeatum to reduce the size of this important palm of the Amazon. The objective of this study was to evaluate the genetic diversity among and within populations of A. acaule by means of AFLP markers. The three populations studied were located in the city of Manaus, and samples of 30 plants were…
Advisors/Committee Members: Lopes, Maria Teresa Gomes, http://lattes.cnpq.br/9307727443790246, Costa Neto, Pedro de Queiroz, http://lattes.cnpq.br/9441888603413825, Martins, Lucia Helena Pinheiro, http://lattes.cnpq.br/6681836743502942.
Subjects/Keywords: Tucum?-do-Amazonas; Palmeiras amaz?nicas; Tarum?-A?u; A. acaule; Amplified Fragment Length Polimorfism; CI?NCIAS AGR?RIAS: RECURSOS FLORESTAIS E ENGENHARIA FLORESTAL; Variabilidade gen?tica; Marcador molecular; Palmeira; AFLP
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APA (6th Edition):
Lima, A. A. P. (2017). Diversidade gen?tica entre e dentro de popula??es de Astrocaryum acaule Mart. (ARECACEAE). (Masters Thesis). Universidade Federal do Amazonas. Retrieved from https://tede.ufam.edu.br/handle/tede/8022
Chicago Manual of Style (16th Edition):
Lima, Aline Ara?jo Patr?cio. “Diversidade gen?tica entre e dentro de popula??es de Astrocaryum acaule Mart. (ARECACEAE).” 2017. Masters Thesis, Universidade Federal do Amazonas. Accessed March 06, 2021.
https://tede.ufam.edu.br/handle/tede/8022.
MLA Handbook (7th Edition):
Lima, Aline Ara?jo Patr?cio. “Diversidade gen?tica entre e dentro de popula??es de Astrocaryum acaule Mart. (ARECACEAE).” 2017. Web. 06 Mar 2021.
Vancouver:
Lima AAP. Diversidade gen?tica entre e dentro de popula??es de Astrocaryum acaule Mart. (ARECACEAE). [Internet] [Masters thesis]. Universidade Federal do Amazonas; 2017. [cited 2021 Mar 06].
Available from: https://tede.ufam.edu.br/handle/tede/8022.
Council of Science Editors:
Lima AAP. Diversidade gen?tica entre e dentro de popula??es de Astrocaryum acaule Mart. (ARECACEAE). [Masters Thesis]. Universidade Federal do Amazonas; 2017. Available from: https://tede.ufam.edu.br/handle/tede/8022
7.
Margrét Guðrún Ásbjarnardóttir 1981-.
Genetic variation within the Icelandic cattle breed: assessment using microsatellites and analysis of single nucleotide polymorphisms in the Leptin and DGAT1 genes
.
Degree: 2011, Agricultural University of Iceland
URL: http://hdl.handle.net/1946/7341
► Sufficient genetic variation within domestic breeds is a crucial factor in all breeding work. It is a prerequisite for future breeding progress and is used…
(more)
▼ Sufficient genetic variation within domestic breeds is a crucial factor in all breeding work. It is a prerequisite for future breeding progress and is used in research and development of
breeding methods at the molecular level. The present study estimates genetic variation within the Icelandic cattle breed using two approaches. The data consisted of genomic
DNA samples from 100 heifers in first pregnancy collected at 45 dairy farms located in the four major dairy regions in Iceland. First, the samples were genotyped with a set of eleven
microsatellite markers and various diversity indices calculated. Second, parts of the Leptin and DGAT1 genes were sequenced in order to search for single nucleotide polymorphisms (SNPs), (several in the Leptin gene and a well known dinucleotide substitution (K232A) in the DGAT1 gene). Polymorphisms in these regions have been identified and associated with commercial traits in different dairy breeds and the purpose was to explore their frequency in Icelandic cattle, as well as to search for breed specific polymorphisms. The Icelandic cattle breed is the only cattle breed in Iceland and has been, more or less, isolated
for over 1000 years; therefore it is considered a closed population. Results from the microsatellite analysis revealed a mean number of observed alleles per locus of 6.182, ranging from 4 (ETH3) to 9 (TGLA53) for individual markers. Mean observed and expected heterozygosity were calculated as 0.626 and 0.685, respectively. Polymorphism information content was high ( 0.5) for all the markers indicating that they can be considered suitable for further research of the Icelandic cattle breed and could be adopted for breeding purposes and parentage testing. Average within population inbreeding coefficient of Icelandic cattle ranged between 8.8 and 9.7% for the three approaches applied and the effective number of individuals was estimated to be 111 individuals (lower and upper 95% confidence limits set as 99.76 and 127.39, respectively). No subdivision of the sample was observed and the breed is not likely to have experienced recent bottlenecks. Three out of the five previously known SNPs were identified in the Leptin gene of Icelandic cattle and a new polymorphism, not previously described in other cattle breeds, was found in intron 2. All heifers analysed were homozygous (carrying the GC/GC dinucleotide) for the K232A polymorphisms in the DGAT1 gene. Together, these results indicate a substantial amount of genetic variation within the Icelandic cattle breed
despite its long isolation and the progressive breeding strategies used for the population in later decades.; Allt kynbótastarf í búfjárstofnum byggist á erfðafjölbreytileika. Hann er grunnforsenda ræktunarframfara og nýtist ennfremur við rannsóknir og þróun kynbótaaðferða sem byggja á sameindaerfðafræði. Í rannsókn þessari var erfðafjölbreytileiki innan íslenska kúastofnsins metinn með tveimur aðferðum sem beitt var á safn erfðaefnis úr 100 íslenskum fyrsta kálfs kvígum. Sýnum var safnað á 45 kúabúum af fjórum megin…
Subjects/Keywords: Íslenskar kýr;
Erfðabreytileiki;
Leptin gen;
DGAT1 gen
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APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
1981-, M. G. . (2011). Genetic variation within the Icelandic cattle breed: assessment using microsatellites and analysis of single nucleotide polymorphisms in the Leptin and DGAT1 genes
. (Thesis). Agricultural University of Iceland. Retrieved from http://hdl.handle.net/1946/7341
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
1981-, Margrét Guðrún Ásbjarnardóttir. “Genetic variation within the Icelandic cattle breed: assessment using microsatellites and analysis of single nucleotide polymorphisms in the Leptin and DGAT1 genes
.” 2011. Thesis, Agricultural University of Iceland. Accessed March 06, 2021.
http://hdl.handle.net/1946/7341.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
1981-, Margrét Guðrún Ásbjarnardóttir. “Genetic variation within the Icelandic cattle breed: assessment using microsatellites and analysis of single nucleotide polymorphisms in the Leptin and DGAT1 genes
.” 2011. Web. 06 Mar 2021.
Vancouver:
1981- MG. Genetic variation within the Icelandic cattle breed: assessment using microsatellites and analysis of single nucleotide polymorphisms in the Leptin and DGAT1 genes
. [Internet] [Thesis]. Agricultural University of Iceland; 2011. [cited 2021 Mar 06].
Available from: http://hdl.handle.net/1946/7341.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
1981- MG. Genetic variation within the Icelandic cattle breed: assessment using microsatellites and analysis of single nucleotide polymorphisms in the Leptin and DGAT1 genes
. [Thesis]. Agricultural University of Iceland; 2011. Available from: http://hdl.handle.net/1946/7341
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universidade do Estado do Rio de Janeiro
8.
Andrezza do Espirito Santo Cucinelli.
Caracterização funcional do gene dip1180 e influência na patogenicidade de cepas de Corynebacterium diphtheriae de origens diversas.
Degree: Master, 2016, Universidade do Estado do Rio de Janeiro
URL: http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=10960
;
► A difteria é uma doença infectocontagiosa, imunoprevenível e de evolução aguda causada, principalmente, pelo Corynebacterium diphtheriae. Além da difteria clássica, o bacilo diftérico tem sido…
(more)
▼ A difteria é uma doença infectocontagiosa, imunoprevenível e de evolução aguda causada, principalmente, pelo Corynebacterium diphtheriae. Além da difteria clássica, o bacilo diftérico tem sido isolado de quadros de infecções invasivas atípicas, associadas a cepas não produtoras de toxina diftérica (TD), indicando o envolvimento de outros fatores de virulência. O primeiro pangenoma desta espécie permitiu identificar 57 ilhas genômicas, com conteúdo gênico altamente diferenciado, evidenciando indícios de transferência gênica horizontal, podendo esta ser uma estratégia para estabelecer diferenças nas interações hospedeiro-patógeno. A importância das hemolisinas na virulência de diferentes espécies bacterianas tem sido cada vez mais enfatizada na literatura, especialmente por serem passíveis de transferência. Algumas cepas de C. diphtheriae podem ser produtoras de hemolisinas, uma vez que são classificadas quanto a atividade hemolí
tica. Contudo, pouco se sabe sobre sua virulência, sendo este o propósito deste trabalho. Inicialmente, foi avaliada a presença de possíveis sequências gênicas codificadoras de hemolisinas em C. diphtheriae. Foi encontrada a sequência de uma proteína com função de citotoxina/hemolisina na cepa NCTC13129, utilizada como modelo para: encontrar sequências nas demais cepas desta espécie; prever a estrutura tridimensional e a semelhança funcional com proteínas de outras espécies; confeccionar primers para avaliação in vitro, através de PCR e construir cepa mutante, por recombinação homóloga. A influência deste gene na patogenicidade da espécie foi avaliada a partir de ensaios sobre a atividade hemolí
tica, interação em superfícies bióticas e abióticas e avaliação da capacidade de causar infecção hematogênica e do osso, in vivo, utilizando camundongos. A sequência codificante da hemolisina DIP1180, encontrada na cepa selvagem, apresentou elevada similaridade nas demais cepas desta espécie, com estrutura tridimensional altamente similar a de hemolisinas de espécies do gênero Streptococcus, reiterando sua possível atividade hemolí
tica. Através do truncamento do gene dip1180, foi possível demonstrar a dependência da atividade hemolí
tica em relação à expressão deste gene em C.diphtheriae. Cepas não produtoras de TD apresentaram atividade hemolí
tica mais intensa. A condição de microareofilia pareceu favorecer a hemólise, exceto para as cepas não hemolíticas, MA 136 e cepa mutante LDCIC-A1. A redução na capacidade de aderir ao poliestireno e ao vidro, observada na cepa mutante demonstrou a influência deste gene na produção de biofilme. No entanto, a privação de ferro no meio de cultivo foi capaz de promover uma expressiva redução na produção de biofilme demonstrando a relevância deste íon na aderência de C. diphtheriae, independente da presença dos genes tox e dip1180. A análise in vivo da influência do gene dip1180 sobre a atividade artritogênica de C. diphtheriae, demonstrou uma redução perceptível da gravidade das lesões apresentadas pelos camundongos infectados com a cepa mutante. Os dados obtidos…
Advisors/Committee Members: Ana Luiza de Mattos Guaraldi, Ana Claudia de Paula Rosa Ignacio, Alessandra Mattos Saliba, Débora Leandro Rama Gomes, Raphael do Carmo Valente.
Subjects/Keywords: C. diphtheriae; Hemolisina; Gene dip1180; Infecções invasivas; Biofilme; C. diphtheriae; Hemolysin; . Gen dip1180; Invasive infections; Biofilm; GENETICA MOLECULAR E DE MICROORGANISMOS; Corynebacterium diphtheriae Teses; Proteínas Hemolisinas; Fatores de virulência
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APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Cucinelli, A. d. E. S. (2016). Caracterização funcional do gene dip1180 e influência na patogenicidade de cepas de Corynebacterium diphtheriae de origens diversas. (Masters Thesis). Universidade do Estado do Rio de Janeiro. Retrieved from http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=10960 ;
Chicago Manual of Style (16th Edition):
Cucinelli, Andrezza do Espirito Santo. “Caracterização funcional do gene dip1180 e influência na patogenicidade de cepas de Corynebacterium diphtheriae de origens diversas.” 2016. Masters Thesis, Universidade do Estado do Rio de Janeiro. Accessed March 06, 2021.
http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=10960 ;.
MLA Handbook (7th Edition):
Cucinelli, Andrezza do Espirito Santo. “Caracterização funcional do gene dip1180 e influência na patogenicidade de cepas de Corynebacterium diphtheriae de origens diversas.” 2016. Web. 06 Mar 2021.
Vancouver:
Cucinelli AdES. Caracterização funcional do gene dip1180 e influência na patogenicidade de cepas de Corynebacterium diphtheriae de origens diversas. [Internet] [Masters thesis]. Universidade do Estado do Rio de Janeiro; 2016. [cited 2021 Mar 06].
Available from: http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=10960 ;.
Council of Science Editors:
Cucinelli AdES. Caracterização funcional do gene dip1180 e influência na patogenicidade de cepas de Corynebacterium diphtheriae de origens diversas. [Masters Thesis]. Universidade do Estado do Rio de Janeiro; 2016. Available from: http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=10960 ;

Universidad de Cantabria
9.
Molina Hoyo, Ester.
CD21/CR2 as a possible Myc target gene in hematopoietic cell lines.
Degree: Máster en Biología Molecular y Biomedicina, 2014, Universidad de Cantabria
URL: http://hdl.handle.net/10902/6080
► c-Myc is a transcription factor which belongs to the family of basic-helix/loop/helix-leucine zipper proteins. It is found deregulated in more than 50% of human tumors,…
(more)
▼ c-Myc is a transcription factor which belongs to the family of basic-helix/loop/helix-leucine zipper proteins. It is found deregulated in more than 50% of human tumors, including Burkitt lymphoma, a human B-cell tumor, where Myc is chromosomally translocated. There is an African epidemic version of Burkitt lymphoma associated with the infection of Epstein-Barr virus (EBV). CD21/CR2 is the co-receptor of B-cell receptor (BCR) that serves as receptor for this virus. We explored whether CR2 could be a potential Myc target gene, since previous results in our laboratory showed that CR2 and Myc were correlated. We have used several hematopoietic cell lines (Raji and K562) in which we have measured CR2 mRNA levels by qPCR upon different conditions of Myc expression. Our results indicate that Myc overexpression in K562 cells results in CR2 overexpression and this effect is reproduced in the absence of protein synthesis. Moreover, in Burkitt cells, inhibition of Myc through the drug JQ1 (which impairs Myc transcription) resulted in CR2 mRNA decrease. The bioinformatic analysis of the ChIP-seq data of the ENCODE project revealed that Myc is bound to the CR2 promoter. Altogether the data strongly suggest that CR2 is a novel Myc target gene and this may explain the association of Burkitt lymphoma in EBV infection.
Advisors/Committee Members: León Serrano, Javier (advisor), Universidad de Cantabria (other).
Subjects/Keywords: Gen diana Myc
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APA ·
Chicago ·
MLA ·
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CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Molina Hoyo, E. (2014). CD21/CR2 as a possible Myc target gene in hematopoietic cell lines. (Masters Thesis). Universidad de Cantabria. Retrieved from http://hdl.handle.net/10902/6080
Chicago Manual of Style (16th Edition):
Molina Hoyo, Ester. “CD21/CR2 as a possible Myc target gene in hematopoietic cell lines.” 2014. Masters Thesis, Universidad de Cantabria. Accessed March 06, 2021.
http://hdl.handle.net/10902/6080.
MLA Handbook (7th Edition):
Molina Hoyo, Ester. “CD21/CR2 as a possible Myc target gene in hematopoietic cell lines.” 2014. Web. 06 Mar 2021.
Vancouver:
Molina Hoyo E. CD21/CR2 as a possible Myc target gene in hematopoietic cell lines. [Internet] [Masters thesis]. Universidad de Cantabria; 2014. [cited 2021 Mar 06].
Available from: http://hdl.handle.net/10902/6080.
Council of Science Editors:
Molina Hoyo E. CD21/CR2 as a possible Myc target gene in hematopoietic cell lines. [Masters Thesis]. Universidad de Cantabria; 2014. Available from: http://hdl.handle.net/10902/6080

University of Iceland
10.
Helga Hjartardóttir 1988-.
Cloning of TCEA1, TCEA1Mut and TCEA1Del genes into mammalian expression vector pcDNA4/TO
.
Degree: 2011, University of Iceland
URL: http://hdl.handle.net/1946/8649
► The RNA polymerase II complex transcribes all protein coding genes in the eukaryotic genome. Its functionality depends on multiple transcription factors and subunits, including the…
(more)
▼ The RNA polymerase II complex transcribes all protein coding genes in the eukaryotic genome. Its functionality depends on multiple transcription factors and subunits, including the elongation factor TFIIS. TFIIS stimulates recovery of backtracked RNA polymerase complexes by transcript cleavage, and loss of function mutations can cause transcriptional blocking of genes with backtracked polymerases. In S. Cerevisiae this elongation factor is not neseccary for cell survival but without it polymerase recovery is a much slower process and this can effect cell viability. Interestingly mutations in certain domains of the yeast TFIIS can not only stop its catalytic effect on transcript cleavage but also inhibit unstimulated RNA polymerase recovery, thus having a leathal effect. To study the effect of mutations in the human TFIIS, encoded by the TCEA1 gene on chromosome 8, the gene has been mutated and has to be cloned into a mammalian expression vector.
Subjects/Keywords: Líffræði;
Frumur;
Gen
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
1988-, H. H. (2011). Cloning of TCEA1, TCEA1Mut and TCEA1Del genes into mammalian expression vector pcDNA4/TO
. (Thesis). University of Iceland. Retrieved from http://hdl.handle.net/1946/8649
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
1988-, Helga Hjartardóttir. “Cloning of TCEA1, TCEA1Mut and TCEA1Del genes into mammalian expression vector pcDNA4/TO
.” 2011. Thesis, University of Iceland. Accessed March 06, 2021.
http://hdl.handle.net/1946/8649.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
1988-, Helga Hjartardóttir. “Cloning of TCEA1, TCEA1Mut and TCEA1Del genes into mammalian expression vector pcDNA4/TO
.” 2011. Web. 06 Mar 2021.
Vancouver:
1988- HH. Cloning of TCEA1, TCEA1Mut and TCEA1Del genes into mammalian expression vector pcDNA4/TO
. [Internet] [Thesis]. University of Iceland; 2011. [cited 2021 Mar 06].
Available from: http://hdl.handle.net/1946/8649.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
1988- HH. Cloning of TCEA1, TCEA1Mut and TCEA1Del genes into mammalian expression vector pcDNA4/TO
. [Thesis]. University of Iceland; 2011. Available from: http://hdl.handle.net/1946/8649
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Iceland
11.
Ásdís Olsen Pétursdóttir 1993-.
Afritafjöldabreytingar í eggjastokkakrabbameinum
.
Degree: 2015, University of Iceland
URL: http://hdl.handle.net/1946/21525
► Krabbameinsfrumur verða oft til við það að eintakafjöldi ákveðinna gena í líkamsfrumum margfaldast og endurröðun verður milli þeirra. Oft er valið fyrir þeim stökkbreytingum sem…
(more)
▼ Krabbameinsfrumur verða oft til við það að eintakafjöldi ákveðinna gena í líkamsfrumum margfaldast og endurröðun verður milli þeirra. Oft er valið fyrir þeim stökkbreytingum sem ýta undir vöxt krabbameina og framvindu þeirra. Með því að finna staðsetningu slíkra afritafjöldabreytinga (e. copy number variations) er hægt að finna mikilvæg krabbameinsgen, það er æxlis- og æxlisbæligen. Til að bera kennsl á þessar breytingar og kanna undirliggjandi gen voru genamengi tíu sjúklinga með eggjastokkakrabbamein borin saman með hjálp þáttapörunar við örflögur (e. array comparative genomic hybridization (aCGH)). Æxlissýnin voru af þremur gerðum, þ.e. jaðaræxli (e. boarderline) og illkynja æxli þar sem sjúklingur var annað hvort BRCA2 arfberi eða ekki. Svæði sem innihéldu stórar afritafjöldabreytingar (e. copy number variations) voru skoðuð ásamt svæðum þar sem breytingar voru í meira en þremur af tíu sýnum. Svæðin voru borin saman við genabanka með hjálp Genome Browser til að finna gen innan þeirra og sérstaklega voru áður þekkt æxlis- og æxlisbæligen athuguð. Niðurstöður sýndu að meira var af litningsbrotum í illkynja æxlunum en í jaðaræxlunum. Á þeim svæðum sem voru með úrfellingar eða margfaldanir í meira en 30 % sýnanna fundust nokkur áður þekkt æxlis- og æxlisbæligen.
Subjects/Keywords: Sameindalíffræði;
Krabbameinsrannsóknir;
Gen
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APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
1993-, . O. P. (2015). Afritafjöldabreytingar í eggjastokkakrabbameinum
. (Thesis). University of Iceland. Retrieved from http://hdl.handle.net/1946/21525
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
1993-, Ásdís Olsen Pétursdóttir. “Afritafjöldabreytingar í eggjastokkakrabbameinum
.” 2015. Thesis, University of Iceland. Accessed March 06, 2021.
http://hdl.handle.net/1946/21525.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
1993-, Ásdís Olsen Pétursdóttir. “Afritafjöldabreytingar í eggjastokkakrabbameinum
.” 2015. Web. 06 Mar 2021.
Vancouver:
1993- OP. Afritafjöldabreytingar í eggjastokkakrabbameinum
. [Internet] [Thesis]. University of Iceland; 2015. [cited 2021 Mar 06].
Available from: http://hdl.handle.net/1946/21525.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
1993- OP. Afritafjöldabreytingar í eggjastokkakrabbameinum
. [Thesis]. University of Iceland; 2015. Available from: http://hdl.handle.net/1946/21525
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Iceland
12.
Hjörleifur Einarsson 1989-.
Search for fusion genes in breast cancers which have amplified regions
.
Degree: 2014, University of Iceland
URL: http://hdl.handle.net/1946/18596
► Breast cancer is the most common cancer in women and genomic aberrations are common in the tumors. Amplifications of chromosomes and chromosomal translocations are examples…
(more)
▼ Breast cancer is the most common cancer in women and genomic aberrations are common in the tumors. Amplifications of chromosomes and chromosomal translocations are examples of such aberrations which can affect tumor development by upregulating gene expression and through the formation of fusion genes. The aim of this assignment is to search for fusion genes in breast cancer tumors with emphasis on known amplified regions. Special focus is on the 8p11-12 region which is amplified in 10-15% of all breast cancers and only one gene in the region has been linked to tumor development. To predict possible fusion genes we ran paired-end RNA sequencing data for chosen breast cancer cell lines and breast cancer tumors through SOAPfuse, an algorithm that detects fusion genes. Chosen fusion gene predictions were further analyzed using Sanger sequencing for validation. With these methods we were able to find and verify fusion genes that were previously known in the MCF7 breast cancer cell line. SOAPfuse analysis for the samples revealed fusion genes which were formed due to translocations, chromosomal inversions and deletions. Some of these fusions were recurrent while others were special for each sample. A NOTCH2NL fusion was detected by SOAPfuse in the T-47D breast cancer cell line and in 5/8 ER+ breast cancer tumors. We verified the fusion in T-47D using Sanger sequencing. NOTCH family genes have previously been found in fusion genes which affect tumor development in breast cancers. Other interesting fusion genes await verification and chosen verified fusion genes will be further studied in Icelandic breast cancer tumors.; Brjóstakrabbamein er algengasta krabbamein í konum og eru erfðabrenglanir algengar í æxlunum. Magnanir á litningasvæðum og litningayfirfærslur eru dæmi um slíkar brenglanir sem geta leitt til æxlismyndunar vegna yfirtjáningar gena eða myndunar samrunagena. Markmið þessa verkefnis er að leita að samrunagenum í brjóstakrabbameinum með áherslu á þekkt mögnunarsvæði. Sérstök áhersla er á 8p11-12 svæðið en það er magnað i 10-15% brjóstaæxla og aðeins eitt áhrifagen æxlismyndunar hefur verið skilgreint á þessu svæði. Til að finna möguleg samrunagen keyrðum við háhraðaraðgreiningargögn fyrir valin brjóstakrabbameinsæxli og brjóstakrabbameins frumulínur í gegnum SOAPfuse forritið sem finnur (leitar eftir) samrunagenum. Af þessum mögulegu samrunagenum voru nokkur valin til frekari greiningar með Sanger raðgreiningu til að staðfesta að þau væru til staðar. Með þessum aðferðum tókst okkur að finna og staðfesta fyrirfram þekkt samrunagen í MCF7 brjóstakrabbameinsfrumulínunni. Könnun á greiningu úr SOAPfuse leiddi í ljós samrunagen sem hafa orðið til vegna litningayfirfærslu, viðsnúninga litningabúta og samruna litningasvæða á sama litningi. Sum samrunagenin koma fyrir í mörgum sýnum, meðan önnur eru einstök fyrir hvert sýni. NOTCH2NL samruni var fundinn af SOAPfuse í T-47D brjóstakrabbameinsfrumulínunni og í 5/8 ER+ brjóstakrabbameinum. NOTCH2NL samruninn var staðfestur…
Subjects/Keywords: Sameindalíffræði;
Brjóstakrabbamein;
Gen
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
1989-, H. E. (2014). Search for fusion genes in breast cancers which have amplified regions
. (Thesis). University of Iceland. Retrieved from http://hdl.handle.net/1946/18596
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
1989-, Hjörleifur Einarsson. “Search for fusion genes in breast cancers which have amplified regions
.” 2014. Thesis, University of Iceland. Accessed March 06, 2021.
http://hdl.handle.net/1946/18596.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
1989-, Hjörleifur Einarsson. “Search for fusion genes in breast cancers which have amplified regions
.” 2014. Web. 06 Mar 2021.
Vancouver:
1989- HE. Search for fusion genes in breast cancers which have amplified regions
. [Internet] [Thesis]. University of Iceland; 2014. [cited 2021 Mar 06].
Available from: http://hdl.handle.net/1946/18596.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
1989- HE. Search for fusion genes in breast cancers which have amplified regions
. [Thesis]. University of Iceland; 2014. Available from: http://hdl.handle.net/1946/18596
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universitat de Valencia
13.
Luna del Valle, Irene.
Estudio del gen WT1 en la leucemia mieloblástica aguda
.
Degree: 2016, Universitat de Valencia
URL: http://hdl.handle.net/10550/53096
► En los últimos años se ha producido un notable progreso en la elucidación de la patogénesis molecular de las Leucemias Mieloblásticas Agudas (LMA). Sin embargo,…
(more)
▼ En los últimos años se ha producido un notable progreso en la elucidación de la patogénesis molecular de las Leucemias Mieloblásticas Agudas (LMA). Sin embargo, la mayoría de las alteraciones genéticas que subyacen en esta patología son todavía desconocidas. La LMA se caracteriza por la presencia de un “stop madurativo” de las células de la línea mieloide, que escapan de la inhibición de las señales anti-proliferativas y adquieren una capacidad indefinida de auto-renovación. Los posibles mecanismos que pueden explicar el crecimiento incontrolado de las células cancerígenas son la pérdida de función de los genes supresores de tumores y/o la activación de los oncogenes. Aunque ambas son funciones opuestas que en principio deberían ser mutuamente excluyentes en una misma proteína, existen evidencias de que una misma proteína puede mostrar ambas funciones bajo condiciones celulares diferentes. Un ejemplo de ello es el
gen del tumor de Wilms (WT1), el cual presenta este tipo de comportamiento dual dependiendo del tipo celular donde se está expresando. El
gen WT1 fue originariamente definido como un
gen supresor tumoral al encontrarse mutado en un 15% de los tumores de Wilms. Sin embargo, el estudio del papel de WT1 en las células cancerígenas ha revelado un inesperado papel como oncogén. La mayoría de estudios se ha realizado en casos de leucemia donde se ha demostrado la importancia biológica y clínica de WT1 en la supervivencia, diferenciación y proliferación celular. En la presente tesis se ha estudiado a un total de 274 pacientes diagnosticados de LMA de novo en un sólo centro para analizar en profundidad el papel de la expresión total de WT1, la expresión de sus 4 isoformas principales, las variaciones genéticas del
gen, tanto mutaciones como el polimorfismo SNP rs16754 y la expresión de los miRNA que podrían estar involucrados en la regulación epigené
tica de WT1, con el objetivo de elucidar el papel de WT1 en la leucemogénesis. Los resultados de esta tesis muestran una expresión de WT1 total mayor en la leucemia en comparación con su contrapartida sana de células CD34+ de sangre de cordón umbilical, que, además, parece conferir una peor supervivencia a los pacientes que pertenecen al subgrupo FAB M0. En cuanto a las cuatro isoformas principales de WT1, los resultados de esta tesis parecen sugerir que dicha sobreexpresión de WT1 total pueda ser debida a un aumento en la expresión de las isoformas A, B y/o C junto a una disminución relativa de la isoforma D. Además, la mejor supervivencia observada en los pacientes que sobreexpresan la isoforma D hace presuponer que dicha isoforma pueda tener un papel protector en la LMA, aunque este resultado debería ser confirmado con futuros estudios funcionales. Tras el cribado de alteraciones genéticas de WT1 por High Resolution Melting, se encontró la presencia de un 30% de pacientes con la presencia del SNP rs16754 de WT1 en heterocigosis, consistente con lo esperable en la población caucásica. La presencia del alelo menor de dicho SNP no mostró diferencias significativas…
Advisors/Committee Members: Sanz Alonso, Miguel Ángel (advisor).
Subjects/Keywords: Leucemia;
Gen Wt1
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Luna del Valle, I. (2016). Estudio del gen WT1 en la leucemia mieloblástica aguda
. (Doctoral Dissertation). Universitat de Valencia. Retrieved from http://hdl.handle.net/10550/53096
Chicago Manual of Style (16th Edition):
Luna del Valle, Irene. “Estudio del gen WT1 en la leucemia mieloblástica aguda
.” 2016. Doctoral Dissertation, Universitat de Valencia. Accessed March 06, 2021.
http://hdl.handle.net/10550/53096.
MLA Handbook (7th Edition):
Luna del Valle, Irene. “Estudio del gen WT1 en la leucemia mieloblástica aguda
.” 2016. Web. 06 Mar 2021.
Vancouver:
Luna del Valle I. Estudio del gen WT1 en la leucemia mieloblástica aguda
. [Internet] [Doctoral dissertation]. Universitat de Valencia; 2016. [cited 2021 Mar 06].
Available from: http://hdl.handle.net/10550/53096.
Council of Science Editors:
Luna del Valle I. Estudio del gen WT1 en la leucemia mieloblástica aguda
. [Doctoral Dissertation]. Universitat de Valencia; 2016. Available from: http://hdl.handle.net/10550/53096
14.
Arslan, Nur.
Asmanın külleme (Erysiphe necator) hastalığına farklı tolerans seviyelerinde tepkisinin WRKY1, DHN1a ve Myc2 gen ifadelerinde Real-time PCR ile belirlenmesi ve metil jasmonatın etkisi: Determination in WRKY, DHN1a and Myc2 gene expression with Real-time PCR in response from the different tolerance level of powdery mildew (Eryshpe necator) disease in grapevine and effect of methyl jasmonate.
Degree: Ziraat Fakültesi, 2018, University of Ankara
URL: http://hdl.handle.net/20.500.12575/68868
► Asma sofralık, şaraplık ve kurutmalık ürün olarak en çok tüketilen bahçe bitkileri arasında yer almaktadır. Külleme (Eryshpe necator) Dünya bağcılığını tehdit eden ve önemli verim…
(more)
▼ Asma sofralık, şaraplık ve kurutmalık ürün olarak en çok tüketilen bahçe bitkileri arasında yer almaktadır. Külleme (Eryshpe necator) Dünya bağcılığını tehdit eden ve önemli verim ve kalite kayıplarına yol açan bir hastalıktır. Külleme hastalığına Vitis vinifera L. türüne ait çeşitlerin tamamına yakını duyarlıdır. Bu çalışmada, Boğazkere (Vitis vinifera L. küllemeye hassas), Cabernet Sauvignon (Vitis vinifera L. küllemeye hassas), Regent (Hibrit Vitis vinifera L. küllemeye tolerant) ve Kishmish Vatkana (Vitis vinifera L. küllemeye Tolerant) çeşitlerinin, külleme ve külleme + MeJa uygulamaları sonrası transkripsiyon faktörü genlerden Myc2, WRKY1 ve DHN1a'nın Real-time PCR ile
gen ifade seviyelerinin belirlenmesi amaçlanmıştır. Araştırmada karşılaştırdığımız hassas ve tolerant çeşitlere ait dal çelikleri köklendirilmelerinin ardından, doğal ortamdan alınan külleme etmeni ile inoküle edilmiştir ve ardından 50µM MeJa uygulaması gerçekleştirilmiştir. Çeşitlere ait yaprak örnekleri uygulamaların ardından 0., 6., 12., 24., 48., 72., 96. ve 120. saatlerde toplanmıştır. Külleme ve külleme + MeJa uygulamalarının Real-time PCR analizleri WRKY1, DHN1a, Myc2 genlerinde gerçekleştirilmiştir. Actin1 geni referans
gen olarak kullanılmıştır. Araştırma sonucunda hassas ve tolerant çeşitlerin farklı mekanizmaları kullandığı ve transkripsiyon faktörü genlerin külleme etmeni ve MeJa varlığında uyarıldığı görülmüştür. Külleme etmeninin 3 gende ve 4 çeşitte farklı ifadeler gösterdiği ve MeJa uygulamasının Erysiphe necator üzerinde etkili bir uyarıcı olduğu belirlenmiştir.
Grape is globally among the most consumed horticulture as table grapes, wine and dried. Powdery mildew (Erysiphe necator) is a disease that threatens the world of viticulture and leads to significant yield and quality losses. Almost all of Vitis vinifera L. species is susceptible in Powdery mildew. In this study, Bogazkere (Vitis vinifera L. Powdery mildew susceptible genotype), Cabernet Sauvignon (Vitis vinifera L. Powdery mildew susceptible genotype), Regent (Hibrit Vitis vinifera L. Powdery mildew resistant genotype) and Kishmish Vatkania (Vitis vinifera L. Powdery mildew resistant genotype) varieties were made with the aim of determining at gene expression levels by Real-time PCR of Myc2, WRKY1 and DHN1a, which are transcription factor genes after Powdery mildew and Powdery mildew + MeJa treatments. After cuttings of the susceptible and resistant genotype which we compared in the study were rooted, they were inoculated with Powdery mildew agent from the natural environment and then 50 μM MeJa treatment was carried out. Leaf samples of varieties were collected at 0., 6., 12., 24., 48., 72., 96. and 120. hours after treatments. Real-time PCR analyzes of the Powdery mildew and Powdery mildew + MeJa treatments were investigated in the WRKY1, DHN1a, Myc2 genes. Actin1 gene was used as housekeeping gene. It has been shown that susceptible and resistant genotypes use different mechanisms and that transcription factor genes are stimulating in the presence of Powdery mildew…
Advisors/Committee Members: Akkurt, Murat (advisor).
Subjects/Keywords: Gen ifadesi; MeJa; Gene expression
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Arslan, N. (2018). Asmanın külleme (Erysiphe necator) hastalığına farklı tolerans seviyelerinde tepkisinin WRKY1, DHN1a ve Myc2 gen ifadelerinde Real-time PCR ile belirlenmesi ve metil jasmonatın etkisi: Determination in WRKY, DHN1a and Myc2 gene expression with Real-time PCR in response from the different tolerance level of powdery mildew (Eryshpe necator) disease in grapevine and effect of methyl jasmonate. (Doctoral Dissertation). University of Ankara. Retrieved from http://hdl.handle.net/20.500.12575/68868
Chicago Manual of Style (16th Edition):
Arslan, Nur. “Asmanın külleme (Erysiphe necator) hastalığına farklı tolerans seviyelerinde tepkisinin WRKY1, DHN1a ve Myc2 gen ifadelerinde Real-time PCR ile belirlenmesi ve metil jasmonatın etkisi: Determination in WRKY, DHN1a and Myc2 gene expression with Real-time PCR in response from the different tolerance level of powdery mildew (Eryshpe necator) disease in grapevine and effect of methyl jasmonate.” 2018. Doctoral Dissertation, University of Ankara. Accessed March 06, 2021.
http://hdl.handle.net/20.500.12575/68868.
MLA Handbook (7th Edition):
Arslan, Nur. “Asmanın külleme (Erysiphe necator) hastalığına farklı tolerans seviyelerinde tepkisinin WRKY1, DHN1a ve Myc2 gen ifadelerinde Real-time PCR ile belirlenmesi ve metil jasmonatın etkisi: Determination in WRKY, DHN1a and Myc2 gene expression with Real-time PCR in response from the different tolerance level of powdery mildew (Eryshpe necator) disease in grapevine and effect of methyl jasmonate.” 2018. Web. 06 Mar 2021.
Vancouver:
Arslan N. Asmanın külleme (Erysiphe necator) hastalığına farklı tolerans seviyelerinde tepkisinin WRKY1, DHN1a ve Myc2 gen ifadelerinde Real-time PCR ile belirlenmesi ve metil jasmonatın etkisi: Determination in WRKY, DHN1a and Myc2 gene expression with Real-time PCR in response from the different tolerance level of powdery mildew (Eryshpe necator) disease in grapevine and effect of methyl jasmonate. [Internet] [Doctoral dissertation]. University of Ankara; 2018. [cited 2021 Mar 06].
Available from: http://hdl.handle.net/20.500.12575/68868.
Council of Science Editors:
Arslan N. Asmanın külleme (Erysiphe necator) hastalığına farklı tolerans seviyelerinde tepkisinin WRKY1, DHN1a ve Myc2 gen ifadelerinde Real-time PCR ile belirlenmesi ve metil jasmonatın etkisi: Determination in WRKY, DHN1a and Myc2 gene expression with Real-time PCR in response from the different tolerance level of powdery mildew (Eryshpe necator) disease in grapevine and effect of methyl jasmonate. [Doctoral Dissertation]. University of Ankara; 2018. Available from: http://hdl.handle.net/20.500.12575/68868

Universidad de Cantabria
15.
Cembranos Bruzón, Rebeca.
Influencia del polimorfismo genético inserción/deleción del gen del enzima convertidor de la Angiotensina (ACE) sobre variables antropométricas y somatotipos en jugadores de balonmano.
Degree: Máster U. en Condicionantes Genéticos, Nutricionales y Ambientales del Crecimiento y el Desarrollo, 2011, Universidad de Cantabria
URL: http://hdl.handle.net/10902/513
► Numerosos estudios previos realizados en deportistas de diversas disciplinas deportivas (tanto a nivel profesional como amateur) evidencian una posible relación entre el rendimiento deportivo y…
(more)
▼ Numerosos estudios previos realizados en deportistas de diversas disciplinas deportivas (tanto a nivel profesional como amateur) evidencian una posible relación entre el rendimiento deportivo y la presencia o ausencia del polimorfismo inserción/deleción del
gen de la Enzima Convertidora de la Angiotensina I (ACE). Dichos trabajos han puesto de manifiesto la relación existente entre el alelo I (inserción) de dicho polimorfismo y el rendimiento en actividades físicas de resistencia; mientras que la presencia del alelo D (deleción) se asocia con actividades de mayor potencia. El balonmano es un deporte colectivo que aúna resistencia y explosividad en todas sus facetas del juego. Esta resistencia y esta velocidad, vienen marcadas por una serie de condiciones físicas de los propios jugadores, la predisposición de los mismos, el entrenamiento e incluso las medidas antropométricas. Existe también otro componente que hasta hace unos años, con el avance de la ciencia no ha sido tan accesible para su estudio; y es el factor genético. Nuestra gené
tica regula y limita tanto características físicas como fisiológicas. Se ha estudiado las posibles semejanzas y diferencias entre jugadores y jugadoras profesionales de balonmano (16 hombres y 11 mujeres); así como las relaciones en cuanto a la posición en el juego, las características antropométricas, el reparto de los porcentajes en la composición corporal y el somatotipo de cada una de ellos. El presente estudio trata encontrar la posible influencia así como de cuánto de influente es el
gen del ACE, y en qué grado modifica e interfiere en la capacidad de hipertrofia muscular del deportista. El estudio realizado analiza las posibles interacciones con este
gen. Para ello, se comparan los parámetros peso y altura que proporcionan el índice de masa corporal (IMC), a través del sumatorio de seis pliegues se obtiene el valor del porcentaje de grasa según Faukner y porcentaje de músculo según Matiegka. Estos porcentajes unidos al resto, nos determinan el somatotipo (o morfotipo) del jugador en cada caso. Y por último, en función de la posiciones del juego, se ha intentado de nuevo averiguar si existe algún tipo de relación. Para la determinación polimorfismo del
gen ACE, se extrajo una muestra de sangre que posteriormente se analizó en el laboratorio. El tratamiento de datos se realizó mediante el paquete estadístico SPSS versión 18.0. Las pruebas estadísticas realizadas correlacionan variables con un mayor o menor grado de significación.
Advisors/Committee Members: González-Lamuño Leguina, Domingo (advisor), Universidad de Cantabria (other).
Subjects/Keywords: Polimorfismo del gen ACE
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Record Details
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Cembranos Bruzón, R. (2011). Influencia del polimorfismo genético inserción/deleción del gen del enzima convertidor de la Angiotensina (ACE) sobre variables antropométricas y somatotipos en jugadores de balonmano. (Masters Thesis). Universidad de Cantabria. Retrieved from http://hdl.handle.net/10902/513
Chicago Manual of Style (16th Edition):
Cembranos Bruzón, Rebeca. “Influencia del polimorfismo genético inserción/deleción del gen del enzima convertidor de la Angiotensina (ACE) sobre variables antropométricas y somatotipos en jugadores de balonmano.” 2011. Masters Thesis, Universidad de Cantabria. Accessed March 06, 2021.
http://hdl.handle.net/10902/513.
MLA Handbook (7th Edition):
Cembranos Bruzón, Rebeca. “Influencia del polimorfismo genético inserción/deleción del gen del enzima convertidor de la Angiotensina (ACE) sobre variables antropométricas y somatotipos en jugadores de balonmano.” 2011. Web. 06 Mar 2021.
Vancouver:
Cembranos Bruzón R. Influencia del polimorfismo genético inserción/deleción del gen del enzima convertidor de la Angiotensina (ACE) sobre variables antropométricas y somatotipos en jugadores de balonmano. [Internet] [Masters thesis]. Universidad de Cantabria; 2011. [cited 2021 Mar 06].
Available from: http://hdl.handle.net/10902/513.
Council of Science Editors:
Cembranos Bruzón R. Influencia del polimorfismo genético inserción/deleción del gen del enzima convertidor de la Angiotensina (ACE) sobre variables antropométricas y somatotipos en jugadores de balonmano. [Masters Thesis]. Universidad de Cantabria; 2011. Available from: http://hdl.handle.net/10902/513

University of Iceland
16.
Ólafur Hreiðar Ólafsson 1997-.
Rannsókn á tengslum erfðabreytileika í og við genin TTN/CCDC141 við hjartsláttartruflanir í gáttum
.
Degree: 2020, University of Iceland
URL: http://hdl.handle.net/1946/35721
► Inngangur: Víðtækar erfðamengisrannsóknir hafa fundið tengsl á milli 170 erfðabreytileika og gáttatifs en minna er vitað um erfðafræði annarra hjartsláttartruflana í gáttum. Nýlegar rannsóknir Íslenskrar…
(more)
▼ Inngangur: Víðtækar erfðamengisrannsóknir hafa fundið tengsl á milli 170 erfðabreytileika og gáttatifs en minna er vitað um erfðafræði annarra hjartsláttartruflana í gáttum. Nýlegar rannsóknir Íslenskrar erfðagreiningar hafa gefið vísbendingar um tengsl erfðabreytileika á svæðinu TTN/CCDC141 við ýmsar hjartsláttartruflanir í gáttum. Markmið þessarar rannsóknar var að meta betur þessi tengsl. Efni og aðferðir: Við safngreindum upplýsingar úr víðtækri erfðamengisleit fyrir hjartsláttartruflanir í gáttum frá Íslandi, UK Biobank og Copenhagen Hospital Biobank en afmörkuðum okkur við svæðið TTN/CCDC141. Við könnuðum tengsl 8366 erfðabreytileika á svæðinu við fjórar hjartsláttartruflanir og notuðum Bonferroni leiðréttingu til að fá marktækniþröskuldinn 6,0×10-6 . Einnig skoðuðum við tengsl erfðabreytileika sem tengdust hjartsláttartruflunum við hjartalínuritsmælingar frá Landspítala og rannsóknum Íslenskrar erfðagreiningar. Niðurstöður: Við fundum tengsl við fjórar hjartsláttartruflanir í gáttum. Erfðabreytileikinn rs2288327 tengdist gáttatifi (P = 2,8 × 10-29, OR (e. odds-ratio, gagnlíkindahlutfall) = 1,11), rs10660645 tengdist sjúkum sínushnúti (P = 6,8 × 10-9 , OR = 1,13), rs13031826 tengdist gáttasleglarofi (= 2,65 × 10-17, OR = 1,23), rs10497529 tengdist ofansleglahraðtakti (P = 1,7 × 10-11, OR = 1,23) og einnig tengdist rs1873164 ofansleglahraðtakti (P = 1,4 × 10-12, OR = 1,22). Allir þessir breytileikar sýndu minna marktæk tengsl við aðra hjartsláttartruflun í gáttum, eina eða fleiri. Skilyrt greining sýndi hins vegar að þau tengsl voru afleiðing tengslaójafnvægis. Allir erfðabreytileikarnir höfðu tengsl við ýmsar hjartalínuritsmælingar, en tengslamynstrið var mismunandi á milli breytileikanna. Engin marktæk tengsl fundust milli þessara erfðabreytileika og háþrýstings, hjartavöðvakvilla, hjartabilunar og kransæðasjúkdóms, sem bendir til þess að áhrif á rafleiðni hjartans miðli tengslum erfðabreytileikanna við hjartsláttartruflanirnar, fremur en aðrir hjartasjúkdómar. Ályktanir: Við sýndum að það eru fimm erfðabreytileikar á svæðinu TTN/CCDC141 sem tengjast mismunandi hjartsláttartruflunum í gáttum og einnig hjartalínuritsmælingum sem mæla rafleiðni í hjartanu. Engu öðru svæði í erfðamenginu hefur verið lýst með víðtækri erfðamengisrannsókn sem hefur áhrif á svona margar mismunandi hjartsláttartruflanir í gáttum. Þessar niðurstöður kalla á frekari rannsóknir til að skilja betur áhrif þessa svæðis á rafleiðni í hjarta.
Subjects/Keywords: Læknisfræði;
Hjartsláttartruflanir;
Gen;
Erfðabreytileiki;
Gáttatif
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APA ·
Chicago ·
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APA (6th Edition):
1997-, . H. . (2020). Rannsókn á tengslum erfðabreytileika í og við genin TTN/CCDC141 við hjartsláttartruflanir í gáttum
. (Thesis). University of Iceland. Retrieved from http://hdl.handle.net/1946/35721
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
1997-, Ólafur Hreiðar Ólafsson. “Rannsókn á tengslum erfðabreytileika í og við genin TTN/CCDC141 við hjartsláttartruflanir í gáttum
.” 2020. Thesis, University of Iceland. Accessed March 06, 2021.
http://hdl.handle.net/1946/35721.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
1997-, Ólafur Hreiðar Ólafsson. “Rannsókn á tengslum erfðabreytileika í og við genin TTN/CCDC141 við hjartsláttartruflanir í gáttum
.” 2020. Web. 06 Mar 2021.
Vancouver:
1997- H. Rannsókn á tengslum erfðabreytileika í og við genin TTN/CCDC141 við hjartsláttartruflanir í gáttum
. [Internet] [Thesis]. University of Iceland; 2020. [cited 2021 Mar 06].
Available from: http://hdl.handle.net/1946/35721.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
1997- H. Rannsókn á tengslum erfðabreytileika í og við genin TTN/CCDC141 við hjartsláttartruflanir í gáttum
. [Thesis]. University of Iceland; 2020. Available from: http://hdl.handle.net/1946/35721
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Iceland
17.
Sölvi Rúnar Vignisson 1989-.
Þróunarleg sérstaða íslenskra skógarþrasta, metin út frá hvatbera DNA
.
Degree: 2012, University of Iceland
URL: http://hdl.handle.net/1946/11592
► Skógarþrestir skiptast í tvær undirtegundir Turdus iliacus iliacus og T. i. coburni. T. i. coburni er undirtegund sem verpir á Íslandi og stöku sinnum í…
(more)
▼ Skógarþrestir skiptast í tvær undirtegundir Turdus iliacus iliacus og T. i. coburni. T. i. coburni er undirtegund sem verpir á Íslandi og stöku sinnum í Færeyjum. Íslenska undirtegundin hefur vetursetu á Írlandi, Skotlandi, Bretlandi, norður Frakklandi og á Íberíuskaga og er töluvert stærri, dekkri og hefur gulbrúnni grunnlit í andliti, á brjósti og undirstélþökum samanborið við T. i. iliacus sem er útbreidd á meginlandi Evrópu og allt austur að 165°A, nánar tiltekið Chukotka Autonomous Okrug í Rússlandi. Ég safnaði sýnum af fuglum sem veiddir voru í Skógræktinni í Fossvogi, einangraði DNA og bar það saman við áður birtar erlendar DNA raðir. Með strikamerkingu (e. barcoding) fann ég vísbendingar fyrir því að það sé lítil sem engin aðgreining í hvatbera DNA með því að athuga hluta af COI (cytochrome c oxidase subunit I) geninu sem bendir til þess að sú aðgreining sem við sjáum í svipfari fuglanna sé fremur nýleg í þrónunarfræðilegum skilningi. Þessi aðgreining gæti hafa verið drifin áfram af náttúrulegu vali eða hröðum tilviljunakenndum breytingum sem gætu hafa átt sér stað í litlum landnámsstofni skógarþrasta á Íslandi. Því er með vissu hægt að segja að þessi gögn styðji ekki kenningu um langan aðskilnað íslenskra skógarþrasta frá öðrum skógarþröstum á meginlandi Evrasíu.; The Redwing is a bird in the thrush family Turdidae. It has two subspecies Turdus iliacus iliacus and T. i. coburni. T. i. coburni breeds in Iceland and the Faroe Islands and winters in Ireland, Scotland, northern France and in Iberia. It is darker overall, larger and has buffier underparts compared to T.i iliacus which breeds in Eurasia. Data collection took place in Skógrækt Fossvogar, Reykjavík Iceland. I looked at sequence variation of the mtDNA COI (cytochrome c oxidase subunit I) used for an international barcode survey, and compared them with previously published sequences of T. i. iliacus. My data reveals that the isolated Icelandic stock in Iceland lacks the support in mtDNA gene trees for avian subspecies. However, phenotypic variation can evolve rapidly so the separation of the subspecies has most likely happened recently and even after the last cold period of the last ice age. In conclusion, there is no support in my data for old separation of the two redwing subspecies, the Icelandic redwing and the redwing on the mainland Europe.
Subjects/Keywords: Líffræði;
Skógarþröstur;
Gen;
Samanburðarrannsóknir
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
1989-, S. R. V. (2012). Þróunarleg sérstaða íslenskra skógarþrasta, metin út frá hvatbera DNA
. (Thesis). University of Iceland. Retrieved from http://hdl.handle.net/1946/11592
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
1989-, Sölvi Rúnar Vignisson. “Þróunarleg sérstaða íslenskra skógarþrasta, metin út frá hvatbera DNA
.” 2012. Thesis, University of Iceland. Accessed March 06, 2021.
http://hdl.handle.net/1946/11592.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
1989-, Sölvi Rúnar Vignisson. “Þróunarleg sérstaða íslenskra skógarþrasta, metin út frá hvatbera DNA
.” 2012. Web. 06 Mar 2021.
Vancouver:
1989- SRV. Þróunarleg sérstaða íslenskra skógarþrasta, metin út frá hvatbera DNA
. [Internet] [Thesis]. University of Iceland; 2012. [cited 2021 Mar 06].
Available from: http://hdl.handle.net/1946/11592.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
1989- SRV. Þróunarleg sérstaða íslenskra skógarþrasta, metin út frá hvatbera DNA
. [Thesis]. University of Iceland; 2012. Available from: http://hdl.handle.net/1946/11592
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Iceland
18.
Ástrós Sigurðardóttir 1987-.
Einangrun erfðavísis glólita í íslenska hestinum
.
Degree: 2012, University of Iceland
URL: http://hdl.handle.net/1946/11643
► Grunnlitir í hrossum eru jarpur, brúnn og rauður. Litaákvörðun á grunnlit hrossa er í Agouti (A) og Extension (E) setum sem táknuð eru af Agouti-signalling…
(more)
▼ Grunnlitir í hrossum eru jarpur, brúnn og rauður. Litaákvörðun á grunnlit hrossa er í Agouti (A) og Extension (E) setum sem táknuð eru af Agouti-signalling próteini (ASIP) og melanocortin-1 viðtaka (MC1R). Frekari litaákvörðun verður m.a. í MATP geni, eða í C seti. Stökkbreytt MATP verður CCr og deyfir grunnlitina. Glóbrúnn, muskóttur eða mórauður er rauðbrúnleitur litur í hestum sem hefur hvergi fundist annars staðar en á Íslandi. Glóbrúna litaafbrigðið kemur einungis fram hjá hrossum sem bera leirljósa erfðavísinn, C+CCr. Eins basa breytingar hafa fundist í OCA2 geni í hrossum. Tvær breytinganna finnast í útröð fimm, sú fyrri er G469A og veldur amínósýrubreytingunni A157T, sú seinni er A541G og veldur amínósýrubreytingunni I181V. Ellefu glóbrún hross voru greind með tilliti til þessara tveggja breytileika í útröð fimm og kom í ljós að þau voru annað hvort GA-AG eða AA-GG ásamt því að vera af arfgerðinni C+CCr. Ásamt glóbrúnu hrossunum voru önnur hross skoðuð þar sem brúna litaafbrigðið var í meirihluta, eitt dökkbrúnt hross kom upp með arfgerðina C+CCr og GA-AA. Það má því álykta að seinni breytileikinn, A541G, hafi afgerandi áhrif á glóbrúna litaákvörðun í íslenska hestinum.
Subjects/Keywords: Líffræði;
Hestalitir;
Gen;
Íslenski hesturinn
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Record Details
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
1987-, . S. (2012). Einangrun erfðavísis glólita í íslenska hestinum
. (Thesis). University of Iceland. Retrieved from http://hdl.handle.net/1946/11643
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
1987-, Ástrós Sigurðardóttir. “Einangrun erfðavísis glólita í íslenska hestinum
.” 2012. Thesis, University of Iceland. Accessed March 06, 2021.
http://hdl.handle.net/1946/11643.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
1987-, Ástrós Sigurðardóttir. “Einangrun erfðavísis glólita í íslenska hestinum
.” 2012. Web. 06 Mar 2021.
Vancouver:
1987- S. Einangrun erfðavísis glólita í íslenska hestinum
. [Internet] [Thesis]. University of Iceland; 2012. [cited 2021 Mar 06].
Available from: http://hdl.handle.net/1946/11643.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
1987- S. Einangrun erfðavísis glólita í íslenska hestinum
. [Thesis]. University of Iceland; 2012. Available from: http://hdl.handle.net/1946/11643
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Iceland
19.
Arnar Ingi Vilhjálmsson 1995-.
Fínstilling á aðstæðum til að framkalla frumuklóna í hreyfitaugafrumum í Drosophila melanogaster
.
Degree: 2019, University of Iceland
URL: http://hdl.handle.net/1946/32404
► Rannsóknarhópur í taugalíffræði við Háskóla Íslands rannsakar hlutverk gena í hreyfitaugafrumum í Drosophila melanogaster. Markmið þessara rannsóknarverkefnis var að meta hvenær í fósturþroskun væri hentugast…
(more)
▼ Rannsóknarhópur í taugalíffræði við Háskóla Íslands rannsakar hlutverk gena í hreyfitaugafrumum í Drosophila melanogaster. Markmið þessara rannsóknarverkefnis var að meta hvenær í fósturþroskun væri hentugast að virkja flippasa til að fá fram frumuklóna í hreyfitaugafrumum án mikilla áhrifa á vöðva og aðra vefi. Þetta var gert með því að nota FLP-out stofn og tvo MARCM stofna sem fóru í hitalost á mismunandi tímum fósturþroskunnar. Við hitalostið mynduðust frumuklónar með flúrljómandi merki í lirfum sem var hægt að taka myndir af undir flúrljómandi víðsjá. Niðurstöðurnar sem fengust gáfu vísbendingar um umfang frumuklónanna og stærð þeirra, en ekki fengust allar þær niðurstöður sem var ætlast til vegna mikilla affalla á fóstrum. Því hefur ekki tekist að svara rannsóknarspurningunum að fullu og þær niðurstöður sem fengust gefa aðeins vísbendingar um umfang frumuklónanna á þeim tímabilum þroskunnar sem tókst að prófa.
Subjects/Keywords: Líffræði;
Taugalíffræði;
Gen;
Hreyfitaugar
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
1995-, A. I. V. (2019). Fínstilling á aðstæðum til að framkalla frumuklóna í hreyfitaugafrumum í Drosophila melanogaster
. (Thesis). University of Iceland. Retrieved from http://hdl.handle.net/1946/32404
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
1995-, Arnar Ingi Vilhjálmsson. “Fínstilling á aðstæðum til að framkalla frumuklóna í hreyfitaugafrumum í Drosophila melanogaster
.” 2019. Thesis, University of Iceland. Accessed March 06, 2021.
http://hdl.handle.net/1946/32404.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
1995-, Arnar Ingi Vilhjálmsson. “Fínstilling á aðstæðum til að framkalla frumuklóna í hreyfitaugafrumum í Drosophila melanogaster
.” 2019. Web. 06 Mar 2021.
Vancouver:
1995- AIV. Fínstilling á aðstæðum til að framkalla frumuklóna í hreyfitaugafrumum í Drosophila melanogaster
. [Internet] [Thesis]. University of Iceland; 2019. [cited 2021 Mar 06].
Available from: http://hdl.handle.net/1946/32404.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
1995- AIV. Fínstilling á aðstæðum til að framkalla frumuklóna í hreyfitaugafrumum í Drosophila melanogaster
. [Thesis]. University of Iceland; 2019. Available from: http://hdl.handle.net/1946/32404
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Iceland
20.
Aðalheiður Elín Lárusdóttir 1992-.
Hlutverk BLIMP1 og EZH2 í lifun Waldenström macroglobulinemia
.
Degree: 2016, University of Iceland
URL: http://hdl.handle.net/1946/24635
► Hlutverk BLIMP1 og EZH2 í lifun Waldenström macroglobulinemia Höfundur: Aðalheiður Elín Lárusdóttir. Leiðbeinandi: dr. Erna Magnúsdóttir. Inngangur: Umritunarþátturinn BLIMP1 er nauðsynlegur í þroskun plasmafruma og…
(more)
▼ Hlutverk BLIMP1 og EZH2 í lifun Waldenström macroglobulinemia
Höfundur: Aðalheiður Elín Lárusdóttir.
Leiðbeinandi: dr. Erna Magnúsdóttir.
Inngangur: Umritunarþátturinn BLIMP1 er nauðsynlegur í þroskun plasmafruma og seytingu ónæmisglóbúlíns. BLIMP1 hamlar bæði gen sem örva frumuskiptingu og gen sem taka þátt í þroskun B-fruma, áður en sérhæfing í plasmafrumu hefst. Hlutverk BLIMP1 í B-frumukrabbameinum er margþætt en það hagar ýmist sem æxlisbæligen eða æxlisgen. EZH2 er hluti fjölkamba bæliflókans 2 (e. Polycomb-Repressive Complex 2). EZH2 er histónmeþýltransferasi, virki efnahvati flókans sem bætir meþýlhópum á histón H3 (H3K27) og á K26 á históni H1. EZH2 kemur við sögu í þroskun B-fruma og er mikilvægt í lifun mergæxlis (e. multiple myeloma). Nýleg gögn benda til þess að BLIMP1 og EZH2 vinni saman við þöggun ýmissa gena í plasmablöstum músa. Waldemström macroglobulinemia (hér eftir WM) er eitilfrumukrabbamein (e. lymphoid neoplasm) sem einkennist af íferð í beinmerg og offramleiðslu einstofna IgM mótefnis. Virkni BLIMP1 og EZH2 í WM hefur ekki verið skoðað. Leitast var við að skoða áhrif BLIMP1 og EZH2 á lifun WM fruma.
Efniviður og aðferðir: Unnið var með nýlega WM frumulínu, RPCI-WMI. Klónar með niðurslætti (e. knock-down) á EZH2 og BLIMP1 voru útbúnir. Áhrif niðursláttar EZH2 og BLIMP1 á frumuskiptingu og frumudauða voru skoðuð í frumuflæðisjá.
Niðurstöður: Niðursláttur á BLIMP1 og EZH2 hindrar frumuskiptingu með því að stýra RPCI-WMI frumum yfir í frumudauða.
Ályktanir: EZH2 og BLIMP1 eru mikilvæg prótín í lifun RPCI-WMI fruma, án þeirra lifa þær ekki af. Gögnin benda til þess að í RPCI-WMI sé BLIMP1 æxlisbæligen. Rannsaka þarf betur samvinnu EZH2 og BLIMP1 í WM í samhengi við önnur prótín sem koma við sögu í stýrðum frumudauða.
Subjects/Keywords: Læknisfræði;
Frumur;
Gen;
Krabbamein
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
1992-, A. E. L. (2016). Hlutverk BLIMP1 og EZH2 í lifun Waldenström macroglobulinemia
. (Thesis). University of Iceland. Retrieved from http://hdl.handle.net/1946/24635
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
1992-, Aðalheiður Elín Lárusdóttir. “Hlutverk BLIMP1 og EZH2 í lifun Waldenström macroglobulinemia
.” 2016. Thesis, University of Iceland. Accessed March 06, 2021.
http://hdl.handle.net/1946/24635.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
1992-, Aðalheiður Elín Lárusdóttir. “Hlutverk BLIMP1 og EZH2 í lifun Waldenström macroglobulinemia
.” 2016. Web. 06 Mar 2021.
Vancouver:
1992- AEL. Hlutverk BLIMP1 og EZH2 í lifun Waldenström macroglobulinemia
. [Internet] [Thesis]. University of Iceland; 2016. [cited 2021 Mar 06].
Available from: http://hdl.handle.net/1946/24635.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
1992- AEL. Hlutverk BLIMP1 og EZH2 í lifun Waldenström macroglobulinemia
. [Thesis]. University of Iceland; 2016. Available from: http://hdl.handle.net/1946/24635
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
21.
Sánchez Pinto, Francisco José Melchor.
Determinación de las frecuencias alélicas de las variantes polimórficas: intrón 3, intrón 6 y codón 72 del gen supresor de tumores tp53 en dos muestras poblacionales del departamento de Lima- Perú.
Degree: 2015, National University of San Marcos
URL: http://hdl.handle.net/20.500.12672/4564
► – The TP53 gene encodes a protein of 53 kDa with important regulatory role in cellular processes such as proliferation, cell death and preservation of…
(more)
▼ – The TP53 gene encodes a protein of 53 kDa with important regulatory role in cellular processes such as proliferation, cell death and preservation of genetic material. Polymorphisms of this gene have a high diversity in the distribution of allele frequencies between ethnic groups and have been linked to cancer susceptibility. By studying PCR-RFLP, was determined the allele frequencies of the polymorphisms, intron 3, intron 6 and codon 72 in 58 students of the University of UNMSM (Lima) and 37 at the University of Jose Faustino Sanchez Carrion. The Allelic and genotypic frequency was measured with the SPSS 11.5 statistical program; and with the Arlequin program ver. 3.5, through Nei index, was established the degree of genetic differentiation between the two populations by considering the intron 3, intron 6 and codon 72, which resulted in 1.793, 1.141 and 0.323 respectively. Both populations are in Hardy-Weinberg equilibrium (p> 0.05) for the three polymorphisms. At codon 72, the allele frequency for proline was 30.1 % in the sample of Lima and 29.7 % in the sample of Huacho. The allele frequency for arginine was 69.8 % for Lima and 70.2 % in Huacho. Regarding the intron 6, the allele frequency for W in Lima was 98.2 % and 81 % in Huacho. In contrast for the M was obtained an allelic frequency of 1.7 % for the studied population of Lima and 18.9 % in Huacho. On the other hand, for the intron 3 the allele frequency for W was 94.6 % for Lima and 90 % in Huacho. In contrast, the allele frequency for M in Lima was 5.3 % and 10 % in Huacho. The dominance of the Arg allele at codon 72 for both populations analyzed is highlighted; and the W allele both intron 6 and intron 3; and the W allele both intron 6 and intron 3. The comparison of allele frequencies of African and Asian descent revealed statistically significant differences (p <0.001); however, was observed a similarity with American and Caucasian populations. KEY WORDS: TP53 gene polymorphism Arg72Pro, intron 6, intron 3, Peruvian populations
Advisors/Committee Members: Velásquez Reinoso, Margarita Rosa Eugenia (advisor).
Subjects/Keywords: Gen TP53; Polimorfismo Arg72Pro
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Sánchez Pinto, F. J. M. (2015). Determinación de las frecuencias alélicas de las variantes polimórficas: intrón 3, intrón 6 y codón 72 del gen supresor de tumores tp53 en dos muestras poblacionales del departamento de Lima- Perú. (Thesis). National University of San Marcos. Retrieved from http://hdl.handle.net/20.500.12672/4564
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Sánchez Pinto, Francisco José Melchor. “Determinación de las frecuencias alélicas de las variantes polimórficas: intrón 3, intrón 6 y codón 72 del gen supresor de tumores tp53 en dos muestras poblacionales del departamento de Lima- Perú.” 2015. Thesis, National University of San Marcos. Accessed March 06, 2021.
http://hdl.handle.net/20.500.12672/4564.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Sánchez Pinto, Francisco José Melchor. “Determinación de las frecuencias alélicas de las variantes polimórficas: intrón 3, intrón 6 y codón 72 del gen supresor de tumores tp53 en dos muestras poblacionales del departamento de Lima- Perú.” 2015. Web. 06 Mar 2021.
Vancouver:
Sánchez Pinto FJM. Determinación de las frecuencias alélicas de las variantes polimórficas: intrón 3, intrón 6 y codón 72 del gen supresor de tumores tp53 en dos muestras poblacionales del departamento de Lima- Perú. [Internet] [Thesis]. National University of San Marcos; 2015. [cited 2021 Mar 06].
Available from: http://hdl.handle.net/20.500.12672/4564.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Sánchez Pinto FJM. Determinación de las frecuencias alélicas de las variantes polimórficas: intrón 3, intrón 6 y codón 72 del gen supresor de tumores tp53 en dos muestras poblacionales del departamento de Lima- Perú. [Thesis]. National University of San Marcos; 2015. Available from: http://hdl.handle.net/20.500.12672/4564
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Iceland
22.
Hrafnhildur Agnarsdóttir 1993-.
The Evolution of Nucleotide Excision Repair Genes in Eukaryotes
.
Degree: 2018, University of Iceland
URL: http://hdl.handle.net/1946/30449
► Major advances in genetics and biotechnology have enabled us to study and compare the genomes of different organisms. With this information available, the evolutionary origin…
(more)
▼ Major advances in genetics and biotechnology have enabled us to study and compare the genomes of different organisms. With this information available, the evolutionary origin of specific genes has been established, along with the fact that some genes are more conserved than others, mainly genes encoding for key metabolic and cellular processes such as replication, transcription and translation. Genes encoding for DNA repair seem to be highly conserved, and may indicate parallel evolution of similar functions in bacteria and archea. Curiously, many DNA repair genes are conserved in humans and yeast, but some seem to have been lost in certain eukaryotic taxa. This study set out to study the perservation of genes involved in the nucleotide excision repair pathway (NER) and map the losses of specific genes among eukaryote groups. The approach was to bioinformatically identify orthologs of proteins involved in this process, using KEGG and Orthodb, and construct a map of perservation and losses.
The key genes in the process were perserved in all taxa, but six genes,thought to be involved in DNA damage detection, DDB2, ERCC6, ERCC8, XPA, TTDA, and CETN2 showed taxonomic-specific losses throughout the eukaryotic domain. For instance DDB2 was found to be lost in three clades (fungi, nematodes and insects), while preserved in vertebrates and plants. Also ERCC6 and ERCC8 were found to be lost two and three times respectively, both lost from species within basidiomycota and dipterans, while ERCC8 was found to be lost earlier in the insect group (also missing from hymenoptera) and four nematode species. A more comprehensive map of the gene content and of the phylogenetic origins of eukaryotes, and the functions of these genes could help us better understand the mechanism of DNA repair and the evolution of conserved systems.; Gríðarlegar framfarir í erfða- og líftækni hafa gert okkur kleift að kanna og bera saman erfðamengi ólíkra lífvera. Með þessar upplýsingar að leiðarljósi hefur þróunarlegur uppruni ákveðinna gena verið skilgreindur, ásamt því að hafa sýnt fram á að sum gen eru betur varðveitt en önnur, einkum þau sem kóða fyrir mikilvægum efnaskipta- og frumuferlum s.s. afritun, umritun og þýðingu. Gen sem kóða fyrir DNA viðgerð virðast vel varðveitt, og gætu gefið til kynna að samhliða þróun svipaðrar virkni í bakteríum og arkeum hafi átt sér stað. Áhugavert er að mörg DNA viðgerðargen eru varðveitt í mönnum og gersveppum, en sum virðast hafa tapast í ákveðnum hópum heilkjörnunga. Markmið þessa verkefnis var að kanna varðveislu þeirra gena er taka þátt í kirniskerðiviðgerð (NER) og kortleggja tap ákveðinna gena meðal heilkjörnungahópa. Lífupplýsingafræðileg nálgun var notuð til að bera kennsl á hliðstæður próteina er taka þátt í þessu ferli með gagnagrunnum frá KEGG og Orthodb, og út frá þeim, kortleggja varðveislu og tap.
Lykilgen í kirniskerðiviðgerðaferlinu voru varðveitt í öllum hópum, en sex þeirra sem talin eru taka þátt í að bera kennsl á DNA skemmdir, DDB2, ERCC6, ERCC8, XPA, TTDA og CETN2, sýndu töp innan…
Subjects/Keywords: Líffræði;
Gen;
DNA-rannsóknir
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
1993-, H. A. (2018). The Evolution of Nucleotide Excision Repair Genes in Eukaryotes
. (Thesis). University of Iceland. Retrieved from http://hdl.handle.net/1946/30449
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
1993-, Hrafnhildur Agnarsdóttir. “The Evolution of Nucleotide Excision Repair Genes in Eukaryotes
.” 2018. Thesis, University of Iceland. Accessed March 06, 2021.
http://hdl.handle.net/1946/30449.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
1993-, Hrafnhildur Agnarsdóttir. “The Evolution of Nucleotide Excision Repair Genes in Eukaryotes
.” 2018. Web. 06 Mar 2021.
Vancouver:
1993- HA. The Evolution of Nucleotide Excision Repair Genes in Eukaryotes
. [Internet] [Thesis]. University of Iceland; 2018. [cited 2021 Mar 06].
Available from: http://hdl.handle.net/1946/30449.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
1993- HA. The Evolution of Nucleotide Excision Repair Genes in Eukaryotes
. [Thesis]. University of Iceland; 2018. Available from: http://hdl.handle.net/1946/30449
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
23.
Matos, Jair da Silva.
Aritm?tica e aplica??es.
Degree: 2017, Universidade Federal do Amazonas
URL: http://tede.ufam.edu.br/handle/tede/6123
► Essa disserta??o de conclus?o de curso tem por objetivo apresentar sucintamente algumas aplica??es imediatas, embora n?o-triviais de Teoria dos N?meros-Aritm?tica, dentre as quais podemos destacar…
(more)
▼ Essa disserta??o de conclus?o de curso tem por objetivo apresentar sucintamente algumas aplica??es
imediatas, embora n?o-triviais de Teoria dos N?meros-Aritm?tica, dentre as quais podemos
destacar o Algoritmo de Euclides, congru?ncias modulares e o Teorema Chin?s dos
Restos. Al?m destes t?picos abordados, damos uma aten??o especial no in?cio deste trabalho
de conclus?o de curso a alguns dos grandes matem?ticos que contribu?ram ? aritm?tica entre
eles, Diofante de Alexandria, Pierre de Fermat, Euclides de Alexandria entre outros. A estrutura
da disserta??o ? a seguinte: No cap?tulo 2 tratamos da revis?o te?rica sobre os n?meros
inteiros e suas propriedades. Destacamos o Princ?pio da Boa Ordena??o, que caracteriza os
n?meros inteiros, tratamos de algumas proposi??es importantes, m?ximo divisor comum e suas
propriedades, n?meros primos, o Teorema Fundamental da Aritm?tica, o Pequeno Teorema de
Fermat, n?meros de Fermat, n?meros de Mersenne, n?meros Perfeitos e finalizamos o cap?tulo
2 com o estudo das congru?ncias e a aritm?tica dos restos. No cap?tulo 3 apresentamos algumas
aplica??es e iniciamos com as Equa??es Diofantinas Lineares, Congru?ncias Lineares e suas
resolu??es, o Teorema Chin?s dos Restos, Classes Residuais e, finalmente, resolvemos problemas
que fizeram parte dos Exames Nacionais de Qualifica??o do PROFMAT desde 2012 at?
2017. Tais problemas s?o resolvidos com as ferramentas propostas no texto, lemas, teoremas,
proposi??es e propriedades, que facilitam a resolu??o. Acreditamos que tais conte?dos servem
para contribuir na forma??o do futuro professor do Ensino B?sico, assim como aprofundar os
conhecimentos daqueles que j? labutam na ?rea do Ensino de Matem?tica.
This dissertation aims to present succinctly some immediate, thout not trivial, Number Theory-
Arithmetic applications, among which we can highlight the Euclidean Algorithm, Modular
Congruences and the Chinese Remainder Theorem. In addition to these topics, we give special
attention at the great mathematicians who contributed to the arithmetic among them, Diophantus
od Alexandria, Pierre de Fermat, Euclides of Alexandria among others. The structure of the
dissertation is as follows: in chapter 2 we deal with the theoretical revision of integers and their
properties. We emphasize the Well Ordering Principle, wich characterizes whole number, we
deal with some important propositions, common maximum divisor and it?s properties, prime
numbers, the Fundamental Theorem of Arithmetic, Fermat?s Little Theorem, Fermat numbers,
Mersenne?s Numbers, Numbers Perfect, and we end with the study of Congruences and the
Arithmetic of the Remains. In chapter 3 we present some applications that we started with the
Linear Diophantine Equations, Linear Congruences and Their resolutions, the Chinese Residue
Theorem, Residual Classes, and finaly we solve problems that were part of the PROFMAT National
Qualification Exams from 2012 to 2017. Such proplems are solved with the tools proposed
in the text, lemmas, theorems, propositions and…
Advisors/Committee Members: Oliveira, Nilomar Vieira de, 32311230204, http://lattes.cnpq.br/4870990824639847, Prata, Roberto Antonio Cordeiro, Amorim Neto, Alcides de Castro, [email protected].
Subjects/Keywords: Aritm?tica; Exame de Qualifica??o; Hist?ria da Aritm?tica; CI?NCIAS EXATAS E DA TERRA: MATEM?TICA
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Matos, J. d. S. (2017). Aritm?tica e aplica??es. (Masters Thesis). Universidade Federal do Amazonas. Retrieved from http://tede.ufam.edu.br/handle/tede/6123
Chicago Manual of Style (16th Edition):
Matos, Jair da Silva. “Aritm?tica e aplica??es.” 2017. Masters Thesis, Universidade Federal do Amazonas. Accessed March 06, 2021.
http://tede.ufam.edu.br/handle/tede/6123.
MLA Handbook (7th Edition):
Matos, Jair da Silva. “Aritm?tica e aplica??es.” 2017. Web. 06 Mar 2021.
Vancouver:
Matos JdS. Aritm?tica e aplica??es. [Internet] [Masters thesis]. Universidade Federal do Amazonas; 2017. [cited 2021 Mar 06].
Available from: http://tede.ufam.edu.br/handle/tede/6123.
Council of Science Editors:
Matos JdS. Aritm?tica e aplica??es. [Masters Thesis]. Universidade Federal do Amazonas; 2017. Available from: http://tede.ufam.edu.br/handle/tede/6123
24.
[No author].
Estudo explorat??rio sobre ??tica nas empresas
.
Degree: 2002, Fundação Escola de Comércio Ãlvares Penteado
URL: http://132.0.0.61:8080/tede/handle/tede/616
► A research about ethic in the companies. Since the beginning of the civilization so much has been said about ethic but, mainly nowadays. Governments talk…
(more)
▼ A research about ethic in the companies. Since the beginning of the civilization so much has been said about ethic but, mainly nowadays. Governments talk about ethic, politicians, religions, in short, everyone talks about ethic. The world of today, which surprises us for the high technology and, at the same time, causes preoccupation with misery, the disrespect with nature, the disrespect with the human being and so many other misfortunes. Everything happens so close in this country, in this city, on the street that we live on. In view of this, the ethic becomes imperious. And, there isn't how to separate the idea of the being that lives in society from the idea of business' society, the companies. This work tries to summarize the historical development of ethic since its origin from the ancient Greece, passing highlighting the ambient in Brazil, since Portuguese influence until nowadays. In the chapter where historical issues are present, there is a subsection where to treat the development and the appearance of the ethic in the companies from the late 40s, mainly in the United States of America. Since it is a research, the studies done in this work, both of them quantity and quality, they are very important in order to characterize the situation of the ethic codes in the companies, and as well the preoccupation with the theme, which companies adopt and the main components of the ethic code. The quantity research demonstrated the preoccupation and importance that the companies are giving to the theme. The quality research, done in the USA, must contribute, it is our expectation, to the improvement and development of the ethic codes in the Brazilian companies.
Advisors/Committee Members: Robles Junior, Antonio (advisor), CPF:02246422868 (advisor), http://lattes.cnpq.br/4447961036109424 (advisor).
Subjects/Keywords: ??tica;
??tica empresarial;
Ethics;
Business ethics
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
author], [. (2002). Estudo explorat??rio sobre ??tica nas empresas
. (Thesis). Fundação Escola de Comércio Ãlvares Penteado. Retrieved from http://132.0.0.61:8080/tede/handle/tede/616
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
author], [No. “Estudo explorat??rio sobre ??tica nas empresas
.” 2002. Thesis, Fundação Escola de Comércio Ãlvares Penteado. Accessed March 06, 2021.
http://132.0.0.61:8080/tede/handle/tede/616.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
author], [No. “Estudo explorat??rio sobre ??tica nas empresas
.” 2002. Web. 06 Mar 2021.
Vancouver:
author] [. Estudo explorat??rio sobre ??tica nas empresas
. [Internet] [Thesis]. Fundação Escola de Comércio Ãlvares Penteado; 2002. [cited 2021 Mar 06].
Available from: http://132.0.0.61:8080/tede/handle/tede/616.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
author] [. Estudo explorat??rio sobre ??tica nas empresas
. [Thesis]. Fundação Escola de Comércio Ãlvares Penteado; 2002. Available from: http://132.0.0.61:8080/tede/handle/tede/616
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
25.
Queiroz, Gide?o Teixeira.
Ensino de Geometria: uma abordagem a partir do uso do Origami.
Degree: 2019, Universidade Federal do Amazonas
URL: https://tede.ufam.edu.br/handle/tede/7435
► Nesse trabalho disserta-se sobre a t?cnica milenar do origami e suas possibilidades de uso na abordagem de resolu??o de problemas de geometria. Inicialmente faz-se um…
(more)
▼ Nesse trabalho disserta-se sobre a t?cnica milenar do origami e suas possibilidades de uso na
abordagem de resolu??o de problemas de geometria. Inicialmente faz-se um itiner?rio hist?rico
mostrando a evolu??o do origami e sua expans?o pelo mundo. Descrevem-se suas caracter?sticas,
classifica??es e algumas de suas aplica??es pr?ticas decorrentes de estudos te?ricos mais
complexos e recentes. Depois se inicia uma discuss?o da matem?tica decorrente dos princ?pios
b?sicos da constru??o de modelos de origami como os Axiomas de Huzita-Justin ou Huzita-
Hatori, Teorema de Maekawa-Justin, Teorema de Kawasaki-Justin e Teorema de Haga. Nesse
ultimo d?-se mais ?nfase por envolver diversos conceitos geom?tricos importantes como semelhan?a
de tri?ngulos, teorema de Pit?goras e fra??es. Finaliza-se mostrando o uso do origami
na resolu??o de alguns problemas geom?tricos interessantes de Olimp?adas de Matem?tica.
In this work, the millenarian technique of origami and its possibilities of use in the problemsolving approach to geometry are discussed. Initially a historical itinerary is made showing the evolution of origami and its expansion around the world. Its characteristics, classifications and some of its practical applications derived from more complex and recent theoretical studies are described. Then begins a discussion of mathematics stemming from the basic principles of building origami models such as Huzita-Justin or Huzita-Hatori Axioms, Maekawa-Justin Theorem, Kawasaki-Justin Theorem, and Haga?s Theorem. In this last one more emphasis is given to involve several important geometric concepts as similarity of triangles, the theorem of Pythagoras and fractions. It ends by showing the use of origami in solving some interesting geometric problems of Mathematical Olympiads.
Advisors/Committee Members: Nascimento, Carlos Wagner Marques do, 5720694292404145, http://lattes.cnpq.br/5720694292404145, Prata, Roberto Ant?nio Cordeiro, http://lattes.cnpq.br/5159150780688575, Amorim Neto, Alcides de Castro, http://lattes.cnpq.br/2095519556544958, [email protected].
Subjects/Keywords: Geometria; Origami; Matem?tica; CI?NCIAS EXATAS E DA TERRA; Matem?tica; Origami; Geometria
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Queiroz, G. T. (2019). Ensino de Geometria: uma abordagem a partir do uso do Origami. (Masters Thesis). Universidade Federal do Amazonas. Retrieved from https://tede.ufam.edu.br/handle/tede/7435
Chicago Manual of Style (16th Edition):
Queiroz, Gide?o Teixeira. “Ensino de Geometria: uma abordagem a partir do uso do Origami.” 2019. Masters Thesis, Universidade Federal do Amazonas. Accessed March 06, 2021.
https://tede.ufam.edu.br/handle/tede/7435.
MLA Handbook (7th Edition):
Queiroz, Gide?o Teixeira. “Ensino de Geometria: uma abordagem a partir do uso do Origami.” 2019. Web. 06 Mar 2021.
Vancouver:
Queiroz GT. Ensino de Geometria: uma abordagem a partir do uso do Origami. [Internet] [Masters thesis]. Universidade Federal do Amazonas; 2019. [cited 2021 Mar 06].
Available from: https://tede.ufam.edu.br/handle/tede/7435.
Council of Science Editors:
Queiroz GT. Ensino de Geometria: uma abordagem a partir do uso do Origami. [Masters Thesis]. Universidade Federal do Amazonas; 2019. Available from: https://tede.ufam.edu.br/handle/tede/7435

Universidad de Extremadura
26.
Gamero Villarroel, Carmen.
Estudio de la influencia de la variabilidad genética en genes de obesidad sobre la etiopatogenia de los trastornos de la alimentación
.
Degree: 2016, Universidad de Extremadura
URL: http://hdl.handle.net/10662/4433
► En los últimos años se han identificado una serie de proteínas capaces de regular la conducta alimentaria y/o modular los rasgos psicopatológicos que presentan los…
(more)
▼ En los últimos años se han identificado una serie de proteínas capaces de regular la conducta alimentaria y/o modular los rasgos psicopatológicos que presentan los pacientes con Trastornos de la Conducta Alimentaria (TCA). El objetivo del trabajo fue establecer si la existencia de polimorfismos en los genes BDNF, NEGR1 y MC4R, relacionados con los mecanismos de regulación de la ingesta, puede influenciar el riesgo a desarrollar un TCA y/o modular parámetros fisiológicos y psicopatológicos. Analizamos 6 polimorfismos del
gen BDNF y 21 del
gen NEGR1 en 169 mujeres con TCA y 312 controles sanos y la secuencia completa del
gen MC4R en tres grupos (170 obesos, 77 mujeres no obesas con comportamiento por atracón diagnosticadas de Bulimina Nerviosa, BN o Trastorno por Atracón y 20 mujeres con Anorexia Nerviosa, AN). Nuestros resultados muestran que ninguno de los SNPs o haplotipos de los genes BDNF y NEGR1 influía en el riesgo de padecer un TCA. Sin embargo, el genotipo TT del SNP rs16917237 del
gen BDNF se asociaba con un aumento del peso e IMC y la presencia de dos haplotipos mostraba un marcado efecto sobre las puntuaciones del cuestionario SCL-90R. En cuanto al
gen NEGR1, destacó la presencia de una región central asociada con mayores puntaciones en varias escalas del cuestionario EDI-2 en pacientes con BN. Finalmente, se identificaron 10 variantes del
gen MC4R en pacientes obesos y solo dos pacientes con comportamiento por atracón eran portadoras del polimorfismo I125L. Podemos concluir que ciertos polimorfismos de los genes BDNF y NEGR1 pueden tener una influencia relevante en determinados rasgos de la personalidad característicos de pacientes con TCA.
Advisors/Committee Members: Gervasini Rodríguez, Guillermo (advisor).
Subjects/Keywords: Gen BDNF;
Gen NEGR1;
Gen MC4R;
BDNF gene;
NEGR1 gene;
MC4R gene;
Trastornos de la conducta alimentaria;
Anorexia;
Bulimia;
Eating disorders
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Gamero Villarroel, C. (2016). Estudio de la influencia de la variabilidad genética en genes de obesidad sobre la etiopatogenia de los trastornos de la alimentación
. (Thesis). Universidad de Extremadura. Retrieved from http://hdl.handle.net/10662/4433
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Gamero Villarroel, Carmen. “Estudio de la influencia de la variabilidad genética en genes de obesidad sobre la etiopatogenia de los trastornos de la alimentación
.” 2016. Thesis, Universidad de Extremadura. Accessed March 06, 2021.
http://hdl.handle.net/10662/4433.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Gamero Villarroel, Carmen. “Estudio de la influencia de la variabilidad genética en genes de obesidad sobre la etiopatogenia de los trastornos de la alimentación
.” 2016. Web. 06 Mar 2021.
Vancouver:
Gamero Villarroel C. Estudio de la influencia de la variabilidad genética en genes de obesidad sobre la etiopatogenia de los trastornos de la alimentación
. [Internet] [Thesis]. Universidad de Extremadura; 2016. [cited 2021 Mar 06].
Available from: http://hdl.handle.net/10662/4433.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Gamero Villarroel C. Estudio de la influencia de la variabilidad genética en genes de obesidad sobre la etiopatogenia de los trastornos de la alimentación
. [Thesis]. Universidad de Extremadura; 2016. Available from: http://hdl.handle.net/10662/4433
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
27.
Ferreira, Alex dos Santos.
A modelagem matem?tica aplicada ao estudo da geometria plana e espacial: ?rea, per?metro e volume.
Degree: 2020, Universidade Federal do Amazonas
URL: https://tede.ufam.edu.br/handle/tede/7785
► Esta disserta??o tem como objetivo abordar a modelagem matem?tica como ferramenta facili- tadora dentro do processo de ensino-aprendizagem, buscando associar a matem?tica ensinada dentro de…
(more)
▼ Esta disserta??o tem como objetivo abordar a modelagem matem?tica como ferramenta facili-
tadora dentro do processo de ensino-aprendizagem, buscando associar a matem?tica ensinada
dentro de sala de aula com o cotidiano do aluno, tendo como prioridade a obten??o do conhe-
cimento por parte do educando. Nessa perspectiva, procurou-se responder qual a import?ncia
e contribui??o do uso da modelagem matem?tica no estudo da geometria plana e espacial no
segundo ano do ensino m?dio? Com isso, buscando produzir uma intera??o entre professor e
aluno, foi deixado para os educandos que eles escolhessem o tema no qual seria estudado os
conte?dos matem?ticos a partir da modelagem. Desse modo, procurou-se entender a aplica??o
dessa estrat?gia como meio facilitador, favorecendo o ensino da geometria e contribuindo para
uma aprendizagem significativa de trinta e um alunos da segunda s?rie do ensino m?dio. Nesse
sentido, foi realizada uma pesquisa bibliogr?fica, na qual buscou-se entender o processo de uti-
liza??o da modelagem, as diferentes concep??es, os obst?culos e a import?ncia da mesma para
o ensino-aprendizagem da matem?tica. Dando continuidade, foi realizada uma atividade com
a modelagem em uma escola estadual na cidade de Beruri-Am, aonde se estudou os conte?dos
matem?ticos a partir do tema Abastecimento de ?gua. Em resumo, concluiu-se que a modela-
gem quando se trabalhada de forma correta, se mostra ser uma ferramenta de suma import?ncia
no ensino e aprendizagem da matem?tica, despertando nos alunos o interesse e a curiosidade
por novos conhecimentos dentro e fora da sala de aula.
This dissertation aimed to approach mathematical modeling as a facilitating tool within the
teaching-learning process, seeking to associate the mathematics taught in the classroom with
the student?s daily life, having as priority the student?s knowledge acquisition. From this pers-
pective, we sought to answer the importance and contribution of the use of mathematical mode-
ling in the study of flat and spatial geometry in the second year of high school? Thus, seeking
to produce an interaction between teacher and student, it was left to the students to choose the
theme in which would be studied the mathematical contents from modeling. Thus, we sought
to understand the application of this strategy as a facilitating means, favoring the teaching of
geometry and contributing to a meaningful learning of thirty-one students in the second grade of
high school. In this sense, a bibliographic research was carried out, which sought to understand
the process of using modeling, the different conceptions, the obstacles and its importance for
the teaching-learning of mathematics. Continuing, an activity was performed with modeling in
a state school in the city of Beruri-Am, where we studied the mathematical contents from the
theme Water Supply. In short, it was concluded that modeling, when worked correctly, proves to
be a very important tool in teaching and learning mathematics, arousing in students the interest
and…
Advisors/Committee Members: Oliveira, Disney Douglas de Lima, http://lattes.cnpq.br/0809035825922353, Oliveira, Nilomar Vieira de, http://lattes.cnpq.br/4870990824639847, Sousa, Jeanne, http://lattes.cnpq.br/3452575521411050.
Subjects/Keywords: Geometria; Matem?tica - Estudo e ensino; Matem?tica (Ensino m?dio); Estrat?gias de aprendizagem; Modelagem matem?tica; CI?NCIAS EXATAS E DA TERRA: MATEM?TICA; Modelagem matem?tica; Ensino e aprendizagem; Estrat?gia; Geometria
Record Details
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Ferreira, A. d. S. (2020). A modelagem matem?tica aplicada ao estudo da geometria plana e espacial: ?rea, per?metro e volume. (Masters Thesis). Universidade Federal do Amazonas. Retrieved from https://tede.ufam.edu.br/handle/tede/7785
Chicago Manual of Style (16th Edition):
Ferreira, Alex dos Santos. “A modelagem matem?tica aplicada ao estudo da geometria plana e espacial: ?rea, per?metro e volume.” 2020. Masters Thesis, Universidade Federal do Amazonas. Accessed March 06, 2021.
https://tede.ufam.edu.br/handle/tede/7785.
MLA Handbook (7th Edition):
Ferreira, Alex dos Santos. “A modelagem matem?tica aplicada ao estudo da geometria plana e espacial: ?rea, per?metro e volume.” 2020. Web. 06 Mar 2021.
Vancouver:
Ferreira AdS. A modelagem matem?tica aplicada ao estudo da geometria plana e espacial: ?rea, per?metro e volume. [Internet] [Masters thesis]. Universidade Federal do Amazonas; 2020. [cited 2021 Mar 06].
Available from: https://tede.ufam.edu.br/handle/tede/7785.
Council of Science Editors:
Ferreira AdS. A modelagem matem?tica aplicada ao estudo da geometria plana e espacial: ?rea, per?metro e volume. [Masters Thesis]. Universidade Federal do Amazonas; 2020. Available from: https://tede.ufam.edu.br/handle/tede/7785

Ruhr Universität Bochum
28.
Schmitz, Caroline Doris.
Absolute Anzahl und altersabhängige Veränderung der
Anzahl regulatorischer T-Zellen bei gesunden und an atopischer
Dermatitit erkrankten Kindern und Jugendlichen.
Degree: 2009, Ruhr Universität Bochum
URL: http://nbn-resolving.de/urn/resolver.pl?urn=urn:nbn:de:hbz:294-25553
► Regulatorische T-Zellen zeichnen sich durch die Oberflächenproteine CD4 und CD25 aus, entwickeln sich teilweise FOXP3- abhängig und werden anhand von CD45RA und CD45RO in naive-like…
(more)
▼ Regulatorische T-Zellen zeichnen sich durch die
Oberflächenproteine CD4 und CD25 aus, entwickeln sich teilweise
FOXP3- abhängig und werden anhand von CD45RA und CD45RO in
naive-like und memory-like regulatorische T-Zellen unterschieden.
Sie spielen eine zentrale Rolle in der Immunhomöostase. Ihre Rolle
im Krankheitsbild der atopischen Dermatitis ist wenig erforscht.
Mit Hilfe durchflusszytometrischer Untersuchungen wurde in der
vorliegenden Studie erstmalig vergleichend die absolute Anzahl und
die altersabhängige Veränderung der Anzahl regulatorischer T-Zellen
bei gesunden und an atopischer Dermatitis erkrankten Kindern und
Jugendlichen untersucht. Patienten mit atopischer Dermatitis wiesen
höhere, vor allem in den ersten vier Lebensjahren deutlich höhere
Anzahlen regulatorischer T-Zellen auf. Die Anzahl naive-like
regulatorischer T-Zellen verringerte sich in beiden
Probandengruppen mit dem Alter statistisch signifikant, umgekehrt
stieg die Anzahl der memory-like regulatorischen
T-Zellen.
Advisors/Committee Members: Medizin.
Subjects/Keywords: Immunologie; Lymphozyt; Forkhead-Gen; Endogenes Ekzem;
Durchflusszytometrie
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Schmitz, C. D. (2009). Absolute Anzahl und altersabhängige Veränderung der
Anzahl regulatorischer T-Zellen bei gesunden und an atopischer
Dermatitit erkrankten Kindern und Jugendlichen. (Thesis). Ruhr Universität Bochum. Retrieved from http://nbn-resolving.de/urn/resolver.pl?urn=urn:nbn:de:hbz:294-25553
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Schmitz, Caroline Doris. “Absolute Anzahl und altersabhängige Veränderung der
Anzahl regulatorischer T-Zellen bei gesunden und an atopischer
Dermatitit erkrankten Kindern und Jugendlichen.” 2009. Thesis, Ruhr Universität Bochum. Accessed March 06, 2021.
http://nbn-resolving.de/urn/resolver.pl?urn=urn:nbn:de:hbz:294-25553.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Schmitz, Caroline Doris. “Absolute Anzahl und altersabhängige Veränderung der
Anzahl regulatorischer T-Zellen bei gesunden und an atopischer
Dermatitit erkrankten Kindern und Jugendlichen.” 2009. Web. 06 Mar 2021.
Vancouver:
Schmitz CD. Absolute Anzahl und altersabhängige Veränderung der
Anzahl regulatorischer T-Zellen bei gesunden und an atopischer
Dermatitit erkrankten Kindern und Jugendlichen. [Internet] [Thesis]. Ruhr Universität Bochum; 2009. [cited 2021 Mar 06].
Available from: http://nbn-resolving.de/urn/resolver.pl?urn=urn:nbn:de:hbz:294-25553.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Schmitz CD. Absolute Anzahl und altersabhängige Veränderung der
Anzahl regulatorischer T-Zellen bei gesunden und an atopischer
Dermatitit erkrankten Kindern und Jugendlichen. [Thesis]. Ruhr Universität Bochum; 2009. Available from: http://nbn-resolving.de/urn/resolver.pl?urn=urn:nbn:de:hbz:294-25553
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Ruhr Universität Bochum
29.
Blißenbach, Maik.
Einfluss des Rev Proteins auf die Verpackung der
genomischen RNA des Humanen Immundefizienzvirus.
Degree: 2010, Ruhr Universität Bochum
URL: http://nbn-resolving.de/urn/resolver.pl?urn=urn:nbn:de:hbz:294-28217
► Obwohl es einen breiten Konsens für die wichtige Rolle des Rev Proteins in der Replikation des Humanen Immundefizienzvirus gibt, sind die Ausmaße der Einzeleffekte des…
(more)
▼ Obwohl es einen breiten Konsens für die wichtige
Rolle des Rev Proteins in der Replikation des Humanen
Immundefizienzvirus gibt, sind die Ausmaße der Einzeleffekte des
Proteins nach wie vor unklar. In dieser Arbeit wurde der Export
genomischer HIV-1 RNA in verschiedenen Zelllinien sowie primärer
Zellkultur untersucht. Dabei zeigte Rev eine 3-12fache Erhöhung der
Mengen an ungespleißter HIV-1 RNA im Zytoplasma. Zugleich stiegen
die Verpackung der genomischen RNA um mehr als 800fach, infektiöse
Titer um mehr als das 1000fache. Diese Daten widersprechen dem
Modell des Rev Proteins als reinem Exportfaktor. Vielmehr scheint
es eine Verbindung zwischen Export und Verpackung zu geben, da die
Kopplung der genomischen HIV-1 RNA an den zellulären
Kernexportfaktor TAP eine effektive Verpackung der RNA ermöglichte,
ohne die zytoplasmatischen RNA-Transkriptzahlen stark zu verändern.
Gesteigerte Gag/Pol-Mengen und erhöhte Titer stützen diese These.
Rev scheint also mehr ein Verpackungsfaktor zu
sein.
Advisors/Committee Members: Chemie.
Subjects/Keywords: HIV; Verpackung; Gen rev; Intrazellulärer
Transport
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Blißenbach, M. (2010). Einfluss des Rev Proteins auf die Verpackung der
genomischen RNA des Humanen Immundefizienzvirus. (Thesis). Ruhr Universität Bochum. Retrieved from http://nbn-resolving.de/urn/resolver.pl?urn=urn:nbn:de:hbz:294-28217
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Blißenbach, Maik. “Einfluss des Rev Proteins auf die Verpackung der
genomischen RNA des Humanen Immundefizienzvirus.” 2010. Thesis, Ruhr Universität Bochum. Accessed March 06, 2021.
http://nbn-resolving.de/urn/resolver.pl?urn=urn:nbn:de:hbz:294-28217.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Blißenbach, Maik. “Einfluss des Rev Proteins auf die Verpackung der
genomischen RNA des Humanen Immundefizienzvirus.” 2010. Web. 06 Mar 2021.
Vancouver:
Blißenbach M. Einfluss des Rev Proteins auf die Verpackung der
genomischen RNA des Humanen Immundefizienzvirus. [Internet] [Thesis]. Ruhr Universität Bochum; 2010. [cited 2021 Mar 06].
Available from: http://nbn-resolving.de/urn/resolver.pl?urn=urn:nbn:de:hbz:294-28217.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Blißenbach M. Einfluss des Rev Proteins auf die Verpackung der
genomischen RNA des Humanen Immundefizienzvirus. [Thesis]. Ruhr Universität Bochum; 2010. Available from: http://nbn-resolving.de/urn/resolver.pl?urn=urn:nbn:de:hbz:294-28217
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
30.
Arslan, Nur.
Asmanın külleme (Erysiphe necator) hastalığına farklı tolerans seviyelerinde tepkisinin WRKY1, DHN1a ve Myc2 gen ifadelerinde Real-time PCR ile belirlenmesi ve metil jasmonatın etkisi: Determination in WRKY, DHN1a and Myc2 gene expression with Real-time PCR in response from the different tolerance level of powdery mildew (Eryshpe necator) disease in grapevine and effect of methyl jasmonate.
Degree: Ziraat Fakültesi, 2018, University of Ankara
URL: http://hdl.handle.net/20.500.12575/68840
► Asma sofralık, şaraplık ve kurutmalık ürün olarak en çok tüketilen bahçe bitkileri arasında yer almaktadır. Külleme (Eryshpe necator) Dünya bağcılığını tehdit eden ve önemli verim…
(more)
▼ Asma sofralık, şaraplık ve kurutmalık ürün olarak en çok tüketilen bahçe bitkileri arasında yer almaktadır. Külleme (Eryshpe necator) Dünya bağcılığını tehdit eden ve önemli verim ve kalite kayıplarına yol açan bir hastalıktır. Külleme hastalığına Vitis vinifera L. türüne ait çeşitlerin tamamına yakını duyarlıdır. Bu çalışmada, Boğazkere (Vitis vinifera L. küllemeye hassas), Cabernet Sauvignon (Vitis vinifera L. küllemeye hassas), Regent (Hibrit Vitis vinifera L. küllemeye tolerant) ve Kishmish Vatkana (Vitis vinifera L. küllemeye Tolerant) çeşitlerinin, külleme ve külleme + MeJa uygulamaları sonrası transkripsiyon faktörü genlerden Myc2, WRKY1 ve DHN1a'nın Real-time PCR ile
gen ifade seviyelerinin belirlenmesi amaçlanmıştır. Araştırmada karşılaştırdığımız hassas ve tolerant çeşitlere ait dal çelikleri köklendirilmelerinin ardından, doğal ortamdan alınan külleme etmeni ile inoküle edilmiştir ve ardından 50µM MeJa uygulaması gerçekleştirilmiştir. Çeşitlere ait yaprak örnekleri uygulamaların ardından 0., 6., 12., 24., 48., 72., 96. ve 120. saatlerde toplanmıştır. Külleme ve külleme + MeJa uygulamalarının Real-time PCR analizleri WRKY1, DHN1a, Myc2 genlerinde gerçekleştirilmiştir. Actin1 geni referans
gen olarak kullanılmıştır. Araştırma sonucunda hassas ve tolerant çeşitlerin farklı mekanizmaları kullandığı ve transkripsiyon faktörü genlerin külleme etmeni ve MeJa varlığında uyarıldığı görülmüştür. Külleme etmeninin 3 gende ve 4 çeşitte farklı ifadeler gösterdiği ve MeJa uygulamasının Erysiphe necator üzerinde etkili bir uyarıcı olduğu belirlenmiştir.
Grape is globally among the most consumed horticulture as table grapes, wine and dried. Powdery mildew (Erysiphe necator) is a disease that threatens the world of viticulture and leads to significant yield and quality losses. Almost all of Vitis vinifera L. species is susceptible in Powdery mildew. In this study, Bogazkere (Vitis vinifera L. Powdery mildew susceptible genotype), Cabernet Sauvignon (Vitis vinifera L. Powdery mildew susceptible genotype), Regent (Hibrit Vitis vinifera L. Powdery mildew resistant genotype) and Kishmish Vatkania (Vitis vinifera L. Powdery mildew resistant genotype) varieties were made with the aim of determining at gene expression levels by Real-time PCR of Myc2, WRKY1 and DHN1a, which are transcription factor genes after Powdery mildew and Powdery mildew + MeJa treatments. After cuttings of the susceptible and resistant genotype which we compared in the study were rooted, they were inoculated with Powdery mildew agent from the natural environment and then 50 μM MeJa treatment was carried out. Leaf samples of varieties were collected at 0., 6., 12., 24., 48., 72., 96. and 120. hours after treatments. Real-time PCR analyzes of the Powdery mildew and Powdery mildew + MeJa treatments were investigated in the WRKY1, DHN1a, Myc2 genes. Actin1 gene was used as housekeeping gene. It has been shown that susceptible and resistant genotypes use different mechanisms and that transcription factor genes are stimulating in the presence of Powdery…
Advisors/Committee Members: Akkurt, Murat (advisor).
Subjects/Keywords: Erysiphe necator; Gen ifadesi; Myc2; Gene expression
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Arslan, N. (2018). Asmanın külleme (Erysiphe necator) hastalığına farklı tolerans seviyelerinde tepkisinin WRKY1, DHN1a ve Myc2 gen ifadelerinde Real-time PCR ile belirlenmesi ve metil jasmonatın etkisi: Determination in WRKY, DHN1a and Myc2 gene expression with Real-time PCR in response from the different tolerance level of powdery mildew (Eryshpe necator) disease in grapevine and effect of methyl jasmonate. (Doctoral Dissertation). University of Ankara. Retrieved from http://hdl.handle.net/20.500.12575/68840
Chicago Manual of Style (16th Edition):
Arslan, Nur. “Asmanın külleme (Erysiphe necator) hastalığına farklı tolerans seviyelerinde tepkisinin WRKY1, DHN1a ve Myc2 gen ifadelerinde Real-time PCR ile belirlenmesi ve metil jasmonatın etkisi: Determination in WRKY, DHN1a and Myc2 gene expression with Real-time PCR in response from the different tolerance level of powdery mildew (Eryshpe necator) disease in grapevine and effect of methyl jasmonate.” 2018. Doctoral Dissertation, University of Ankara. Accessed March 06, 2021.
http://hdl.handle.net/20.500.12575/68840.
MLA Handbook (7th Edition):
Arslan, Nur. “Asmanın külleme (Erysiphe necator) hastalığına farklı tolerans seviyelerinde tepkisinin WRKY1, DHN1a ve Myc2 gen ifadelerinde Real-time PCR ile belirlenmesi ve metil jasmonatın etkisi: Determination in WRKY, DHN1a and Myc2 gene expression with Real-time PCR in response from the different tolerance level of powdery mildew (Eryshpe necator) disease in grapevine and effect of methyl jasmonate.” 2018. Web. 06 Mar 2021.
Vancouver:
Arslan N. Asmanın külleme (Erysiphe necator) hastalığına farklı tolerans seviyelerinde tepkisinin WRKY1, DHN1a ve Myc2 gen ifadelerinde Real-time PCR ile belirlenmesi ve metil jasmonatın etkisi: Determination in WRKY, DHN1a and Myc2 gene expression with Real-time PCR in response from the different tolerance level of powdery mildew (Eryshpe necator) disease in grapevine and effect of methyl jasmonate. [Internet] [Doctoral dissertation]. University of Ankara; 2018. [cited 2021 Mar 06].
Available from: http://hdl.handle.net/20.500.12575/68840.
Council of Science Editors:
Arslan N. Asmanın külleme (Erysiphe necator) hastalığına farklı tolerans seviyelerinde tepkisinin WRKY1, DHN1a ve Myc2 gen ifadelerinde Real-time PCR ile belirlenmesi ve metil jasmonatın etkisi: Determination in WRKY, DHN1a and Myc2 gene expression with Real-time PCR in response from the different tolerance level of powdery mildew (Eryshpe necator) disease in grapevine and effect of methyl jasmonate. [Doctoral Dissertation]. University of Ankara; 2018. Available from: http://hdl.handle.net/20.500.12575/68840
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