subject:(Gastric Ulceration)

University of Helsinki

1. Forsman, Cecilia. The association between gastric ulceration and clinical signs in adult horses.

Degree: Department of Equine and Small Animal Medicine; Helsingin yliopisto, Eläinlääketieteellinen tiedekunta, Kliinisen hevos- ja pieneläinlääketieteen osasto; Helsingfors universitet, Veterinärmedicinska fakulteten, Avdelningen för klinisk häst- och smådjursmedicin, 2014, University of Helsinki

URL: http://hdl.handle.net/10138/135173

► Clinical signs associated with equine gastric ulceration are commonly reported in the literature, but are vague and often unsubstantiated. Clinical signs of gastric ulceration in… (more)

▼ Clinical signs associated with equine gastric ulceration are commonly reported in the literature, but are vague and often unsubstantiated. Clinical signs of gastric ulceration in yearlings and mature horses are less well recognized than in foals, but may be more important economically. There are no studies in the literature that have investigated the statistical association between clinical signs and gastric ulceration. The aim of this study was to determine whether there is a statistical association between commonly reported clinical signs of gastric ulceration and gastric ulcer severity as determined by endoscopic examination of the stomach. The hypothesis of this study was that there is no association between the severity of gastric ulceration and the owners perception of clinical signs of gastric ulceration. To achieve statistical significance, the study included 100 horses. A gastroscopic examination was performed on all the horses and documented on video. Owners were then asked to fill in a questionnaire documenting the clinical signs exhibited by their horses in the 3 months prior to the examination. The ulcers where graded into four categories1) presence or absence of gastric ulcers; 2) presence or absence of clinical significant gastric ulcers (i.e. needing treatment or not); 3) presence or absence of glandular ulcers; and 4) presence or absence of non-glandular ulcers. The four categories where compared to the clinical signs using a Pearson Chi-Square or Mann- Whitney U-test. Significance was set at p<0.05. A statistical association was found between clinical significant ulcers and losing weight (p=0,01) and between ulcer or no ulcer and losing weight (p=0,051). The results suggest that an owners perception of their horse losing weight could be associated with the presence of gastric ulcers and an increased severity of gastric ulcers, and can be used as an indication to perform gastroscopy on these individuals. There was no association between gastric ulcer severity and the owners perception of colic, crib-biting, flank-biting, fussy eating, changes in behaviour, chronic diarrhoea, bruxism, poor body condition, poor coat condition and poor performance, and requests from owners to have gastroscopy performed on their horses based upon these clinical signs should be approached with caution.

Subjects/Keywords: equine gastric ulceration; clinical sign; statistics; Hevosten sisätaudit; Hästar internmedicin; Equine Internal Medicine; equine gastric ulceration; clinical sign; statistics

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Forsman, C. (2014). The association between gastric ulceration and clinical signs in adult horses. (Thesis). University of Helsinki. Retrieved from http://hdl.handle.net/10138/135173

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Forsman, Cecilia. “The association between gastric ulceration and clinical signs in adult horses.” 2014. Thesis, University of Helsinki. Accessed March 08, 2021. http://hdl.handle.net/10138/135173.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Forsman, Cecilia. “The association between gastric ulceration and clinical signs in adult horses.” 2014. Web. 08 Mar 2021.

Vancouver:

Forsman C. The association between gastric ulceration and clinical signs in adult horses. [Internet] [Thesis]. University of Helsinki; 2014. [cited 2021 Mar 08]. Available from: http://hdl.handle.net/10138/135173.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Forsman C. The association between gastric ulceration and clinical signs in adult horses. [Thesis]. University of Helsinki; 2014. Available from: http://hdl.handle.net/10138/135173

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Virginia Tech

2. Ward, Deborah Marie. Effect of Dosing Interval on the Efficacy of Misoprostol in the Prevention of Aspirin-Induced gastric Injury in the Dog.

Degree: MS, Veterinary Medical Sciences, 2000, Virginia Tech

URL: http://hdl.handle.net/10919/31629

► The effect of reduced frequency of administration of misoprostol on its ability to prevent aspirin-induced gastric injury was evaluated. Twenty-four random-source dogs were divided into… (more)

▼ The effect of reduced frequency of administration of misoprostol on its ability to prevent aspirin-induced gastric injury was evaluated. Twenty-four random-source dogs were divided into 4 groups which received aspirin and misoprostol as follows: Group I, 25 mg/kg aspirin PO TID and placebo PO TID; Group II, 25 mg/kg aspirin PO TID and misoprostol 3 ug/kg PO TID; Group III, 25 mg/kg aspirin PO TID, misoprostol 3 ug/kg PO BID and placebo PO QD; and Group IV, 25 mg/kg aspirin PO TID, misoprostol 3 ug/kg PO QD and placebo PO BID for 28 days. Groups were stratified to contain an equal number of dogs positive or negative for Helicobacter spp. based on results of ‘CLO test’. Gastroscopy was performed on days –9, 5, 14 and 28. Each region of the stomach was evaluated separately and visible lesions were scored on a scale of 1 (submucosal hemorrhage) to 11 (perforating ulcer). The scores for each region were summed and the median total score for each group at each day and median total score within each group between days was compared using a Kruskal-Wallis test. No difference in total score was identified between Group I and IV on any day. Median total scores for Groups II and III were significantly(p < 0.05) lower compared to Groups I and IV on day 5. Significant difference was observed on Day 14 between the total score of Group III and Group IV. Group III had a significantly lower score (p < 0.05) than Groups I, II and IV on day 28. Gastric erosions were present in all groups in the study. This study suggests that misoprostol 3 ug/kg PO BID dosing is as effective as misoprostol 3 ug/kg PO TID dosing at preventing aspirin-induced gastric injury in this model. However, misoprostol 3 ug/kg PO TID dosing was less effective in preventing aspirin-induced gastric injury on days 14 and 28 than in previous studies. The lack of efficacy of TID dosing on days 14 and 28 may be related to higher salicylate concentrations in Group II dogs or individual variation within the small study population. Advisors/Committee Members: Leib, Michael S. (committeechair), Monroe, William Edward (committee member), Johnston, Spencer A. (committee member), Duncan, Robert B. Jr. (committee member).

Subjects/Keywords: NSAIDs; dogs; gastric ulceration; Aspirin; misoprostol

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Ward, D. M. (2000). Effect of Dosing Interval on the Efficacy of Misoprostol in the Prevention of Aspirin-Induced gastric Injury in the Dog. (Masters Thesis). Virginia Tech. Retrieved from http://hdl.handle.net/10919/31629

Chicago Manual of Style (16^th Edition):

Ward, Deborah Marie. “Effect of Dosing Interval on the Efficacy of Misoprostol in the Prevention of Aspirin-Induced gastric Injury in the Dog.” 2000. Masters Thesis, Virginia Tech. Accessed March 08, 2021. http://hdl.handle.net/10919/31629.

MLA Handbook (7^th Edition):

Ward, Deborah Marie. “Effect of Dosing Interval on the Efficacy of Misoprostol in the Prevention of Aspirin-Induced gastric Injury in the Dog.” 2000. Web. 08 Mar 2021.

Vancouver:

Ward DM. Effect of Dosing Interval on the Efficacy of Misoprostol in the Prevention of Aspirin-Induced gastric Injury in the Dog. [Internet] [Masters thesis]. Virginia Tech; 2000. [cited 2021 Mar 08]. Available from: http://hdl.handle.net/10919/31629.

Council of Science Editors:

Ward DM. Effect of Dosing Interval on the Efficacy of Misoprostol in the Prevention of Aspirin-Induced gastric Injury in the Dog. [Masters Thesis]. Virginia Tech; 2000. Available from: http://hdl.handle.net/10919/31629

Virginia Tech

3. Graham, Allison Heather. Effects of Prednisone or Prednisone with Ultralow-Dose Aspirin on the Gastroduodenal Mucosa of Healthy Dogs.

Degree: MS, Veterinary Medical Sciences, 2009, Virginia Tech

URL: http://hdl.handle.net/10919/31530

► This study tested the hypothesis that administration of immunosuppressive doses of prednisone in conjunction with ultralow-dose aspirin (0.5 mg/kg/day) would result in gastroduodenal lesion scores… (more)

▼ This study tested the hypothesis that administration of immunosuppressive doses of prednisone in conjunction with ultralow-dose aspirin (0.5 mg/kg/day) would result in gastroduodenal lesion scores similar to those found in dogs administered only immunosuppressive doses of prednisone, but that the gastroduodenal scores from both of these treatment groups would be significantly higher than placebo when administered to healthy dogs for 27 days. Eighteen healthy adult purpose-bred dogs were divided randomly into three groups. Group I received placebo capsules and placebo suspension, Group II received prednisone capsules (mean 2.3 mg/kg, range 2.0-2.4) and placebo suspension, and Group III received prednisone capsules (mean 2.3 mg/kg, range 2.3-2.5) and aspirin suspension (0.5 mg/kg) by mouth once daily for 27 days. Gastroduodenoscopy was performed on days -7 (baseline), 5, 14, and 27 of treatment. Four regions of the stomach (angularis incisura, body, pylorus, and cardia) and the proximal descending duodenum were systematically scored on a scale of 1 (normal) to 11 (perforating ulcer) by an experienced observer who was blinded to the treatment groups and clinical signs of each subject. Dogs were observed every 8 hours for vomiting, diarrhea, and inappetence. Feces were scored on a scale of 1-5 with diarrhea defined as a fecal score <4. Lesion scores for each group, at each location, and total scores, at each time period were evaluated for the effects of time and treatment using a Kruskal-Wallis test. Total dog days of vomiting and dog days of diarrhea in each group were compared using a Wilcoxon rank sums test. Significance was determined at p<0.05. There were no significant differences in median total gastric lesion scores between any of the groups at any time during the study. There was no location effect on regional gastroduodenal lesion scores and there was no significant change in gastroduodenal lesion scores over time in any of the groups during treatment. Significantly more dog-days of diarrhea occurred within the prednisone and aspirin group during the experimental period (Period 2) in comparison to Period 1. However, no significant differences were found between any of the groups for dog-days of vomiting, diarrhea or inappetence at any time in the study. Advisors/Committee Members: Leib, Michael S. (committeechair), Ehrich, Marion F. (committee member), Grant, David C. (committee member), Troy, Gregory C. (committee member).

Subjects/Keywords: aspirin; prednisone; gastroduodenoscopy; gastric ulceration; canine

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Graham, A. H. (2009). Effects of Prednisone or Prednisone with Ultralow-Dose Aspirin on the Gastroduodenal Mucosa of Healthy Dogs. (Masters Thesis). Virginia Tech. Retrieved from http://hdl.handle.net/10919/31530

Chicago Manual of Style (16^th Edition):

Graham, Allison Heather. “Effects of Prednisone or Prednisone with Ultralow-Dose Aspirin on the Gastroduodenal Mucosa of Healthy Dogs.” 2009. Masters Thesis, Virginia Tech. Accessed March 08, 2021. http://hdl.handle.net/10919/31530.

MLA Handbook (7^th Edition):

Graham, Allison Heather. “Effects of Prednisone or Prednisone with Ultralow-Dose Aspirin on the Gastroduodenal Mucosa of Healthy Dogs.” 2009. Web. 08 Mar 2021.

Vancouver:

Graham AH. Effects of Prednisone or Prednisone with Ultralow-Dose Aspirin on the Gastroduodenal Mucosa of Healthy Dogs. [Internet] [Masters thesis]. Virginia Tech; 2009. [cited 2021 Mar 08]. Available from: http://hdl.handle.net/10919/31530.

Council of Science Editors:

Graham AH. Effects of Prednisone or Prednisone with Ultralow-Dose Aspirin on the Gastroduodenal Mucosa of Healthy Dogs. [Masters Thesis]. Virginia Tech; 2009. Available from: http://hdl.handle.net/10919/31530

Virginia Tech

4. Hepburn, Richard James. Investigation into the Presence of Helicobacter in the Equine Stomach by Urease Testing and Polymerase Chain Reaction and Further Investigation into the Application of the 13C-Urea Blood Test to the Horse.

Degree: MS, Veterinary Medical Sciences, 2004, Virginia Tech

URL: http://hdl.handle.net/10919/33587

► Equine gastric glandular mucosal ulceration can have a prevalence of 58%, yet its etiology is poorly understood. In man Helicobacter pylori is the most common… (more)

Subjects/Keywords: Helicobacter; Gastric Ulceration; Horse; 13C-Urea; Blood Test

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Hepburn, R. J. (2004). Investigation into the Presence of Helicobacter in the Equine Stomach by Urease Testing and Polymerase Chain Reaction and Further Investigation into the Application of the 13C-Urea Blood Test to the Horse. (Masters Thesis). Virginia Tech. Retrieved from http://hdl.handle.net/10919/33587

Chicago Manual of Style (16^th Edition):

Hepburn, Richard James. “Investigation into the Presence of Helicobacter in the Equine Stomach by Urease Testing and Polymerase Chain Reaction and Further Investigation into the Application of the 13C-Urea Blood Test to the Horse.” 2004. Masters Thesis, Virginia Tech. Accessed March 08, 2021. http://hdl.handle.net/10919/33587.

MLA Handbook (7^th Edition):

Hepburn, Richard James. “Investigation into the Presence of Helicobacter in the Equine Stomach by Urease Testing and Polymerase Chain Reaction and Further Investigation into the Application of the 13C-Urea Blood Test to the Horse.” 2004. Web. 08 Mar 2021.

Vancouver:

Hepburn RJ. Investigation into the Presence of Helicobacter in the Equine Stomach by Urease Testing and Polymerase Chain Reaction and Further Investigation into the Application of the 13C-Urea Blood Test to the Horse. [Internet] [Masters thesis]. Virginia Tech; 2004. [cited 2021 Mar 08]. Available from: http://hdl.handle.net/10919/33587.

Council of Science Editors:

Hepburn RJ. Investigation into the Presence of Helicobacter in the Equine Stomach by Urease Testing and Polymerase Chain Reaction and Further Investigation into the Application of the 13C-Urea Blood Test to the Horse. [Masters Thesis]. Virginia Tech; 2004. Available from: http://hdl.handle.net/10919/33587

Curtin University of Technology

5. McWilliams, Tracy. Proteome comparison of helicobacter pylori isolates associated with four disease groups .

Degree: 2006, Curtin University of Technology

URL: http://hdl.handle.net/20.500.11937/1114

► The Gram-negative bacterium Helicobacter pylori is found in human gastric mucosa. H. pylori, one of the most common chronic bacterial infections of humans, is present… (more)

▼ The Gram-negative bacterium Helicobacter pylori is found in human gastric mucosa. H. pylori, one of the most common chronic bacterial infections of humans, is present in almost half of the world population. It is associated with chronic gastritis, non-ulcer dyspepsia, gastric and duodenal ulcers, and malignant neoplasms. The aim of this study was to detect microbial candidate protein markers whose presence might be correlated with the development of four different clinical consequences of H. pylori infection, gastric ulceration [GU], duodenal ulceration [DU], non-ulcer dyspepsia [NUD] and gastritis [GI]. Eleven H. pylori isolates associated with these outcomes were analysed. The total complement of protein from these H. pylori isolates were resolved by two-dimensional polyacrylamide gel electrophoresis (2D-PAGE) and compared using PDQUEST pattern analysis software. Relationships between the isolates associated with specific disease outcomes were determined by cluster analysis.Fifty six disease specific proteins were then characterised by tryptic peptide-mass fingerprinting using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS). Up to 1165 protein species were resolved from each H. pylori strain. Proteome analysis revealed that only 470 (40%) of the proteins detected were common to all eleven isolates. Twenty six of the 56 disease specific proteins that were selected for identification consisted of spots whose expression is altered in response to stress conditions or those that can affect H. pylori cell division and the cell membrane. The remaining 30 proteins had no known function. This study has provided further confirmation of the extensive variation that the bacterium H. pylori exhibits at the proteome level. Most significantly this study has found, through the application of cluster analysis and protein matching, that isolates do form disease groups. Comparative proteome analysis is a useful method for highlighting the extensive strain variation that H. pylori exhibits and to determine if any disease specific proteins exist.

Subjects/Keywords: Helicobacter pylori; gastric ulceration; gastritis; duodenal ulceration; microbial candidate protein markers; bacterial infections; non-ulcer dyspepsia

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

McWilliams, T. (2006). Proteome comparison of helicobacter pylori isolates associated with four disease groups . (Thesis). Curtin University of Technology. Retrieved from http://hdl.handle.net/20.500.11937/1114

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

McWilliams, Tracy. “Proteome comparison of helicobacter pylori isolates associated with four disease groups .” 2006. Thesis, Curtin University of Technology. Accessed March 08, 2021. http://hdl.handle.net/20.500.11937/1114.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

McWilliams, Tracy. “Proteome comparison of helicobacter pylori isolates associated with four disease groups .” 2006. Web. 08 Mar 2021.

Vancouver:

McWilliams T. Proteome comparison of helicobacter pylori isolates associated with four disease groups . [Internet] [Thesis]. Curtin University of Technology; 2006. [cited 2021 Mar 08]. Available from: http://hdl.handle.net/20.500.11937/1114.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

McWilliams T. Proteome comparison of helicobacter pylori isolates associated with four disease groups . [Thesis]. Curtin University of Technology; 2006. Available from: http://hdl.handle.net/20.500.11937/1114

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Virginia Tech

6. Sennello, Kathleen Ann. Comparison of the Effects of Deracoxib, Buffered Aspirin, and Placebo on the Gastric Mucosa of Healthy Dogs.

Degree: MS, Veterinary Medical Sciences, 2005, Virginia Tech

URL: http://hdl.handle.net/10919/31788

► This study tested the hypothesis that administration of deracoxib, a cyclooxygenase-2 specific (COX-2) inhibitor, would result in lower gastric lesion scores than administration of buffered… (more)

▼ This study tested the hypothesis that administration of deracoxib, a cyclooxygenase-2 specific (COX-2) inhibitor, would result in lower gastric lesion scores than administration of buffered aspirin and gastric lesion scores similar to placebo when administered to healthy dogs for 28 days. Twenty-four, healthy, random source dogs were divided into three groups. Group I received buffered aspirin, 23.6 mg/kg PO q 8h, group II received deracoxib, 1.6 mg/kg PO q 24h and placebo twice daily PO q 8h after deracoxib administration, and group III received placebo PO q 8h. Gastroscopy was performed on days -7, 6, 14, and 28 of treatment. Four regions of the stomach (pylorus, incisura, cardia, and body) were evaluated separately and lesions scored on a scale of 1 (mucosal hemorrhage) to 12 (perforating ulcer) by an observer unaware of which treatments the dogs received. Dogs were observed every 8 hours for vomiting, diarrhea and anorexia. Feces were scored from 1-5 (scores <4 were considered diarrhea). Lesion scores for each group, at each location, and total scores, at each time period, were evaluated for the effects of time and treatment using a Kruskal-Wallis test. Total dog days of vomiting and dog days of diarrhea in each group were compared using a Wilcoxon rank sums test. Significance was determined at p<0.05. Significantly higher median total gastric lesion scores were found in the aspirin group compared to the deracoxib or placebo groups on days 6, 14, and 28. There were no significant differences in median total gastric lesion scores between the deracoxib or placebo groups at any time during the study. There was no location effect on gastric lesion scores and there was no significant change in gastric lesion scores over time in any of the groups during treatment. Significantly more dog-days of vomiting occurred in the aspirin group as compared to the deracoxib group. No significant differences were found between groups for dog-days of diarrhea. In this study, the administration of deracoxib to healthy dogs resulted in significantly lower gastric lesion scores compared to dogs receiving aspirin and lesion scores similar to those receiving placebo. Advisors/Committee Members: Leib, Michael S. (committeechair), Ehrich, Marion F. (committee member), Monroe, William Edward (committee member).

Subjects/Keywords: gastroscopy; cyclooxygenase; gastric ulceration; non-steroidal anti-inflammatory drugs; canine

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Sennello, K. A. (2005). Comparison of the Effects of Deracoxib, Buffered Aspirin, and Placebo on the Gastric Mucosa of Healthy Dogs. (Masters Thesis). Virginia Tech. Retrieved from http://hdl.handle.net/10919/31788

Chicago Manual of Style (16^th Edition):

Sennello, Kathleen Ann. “Comparison of the Effects of Deracoxib, Buffered Aspirin, and Placebo on the Gastric Mucosa of Healthy Dogs.” 2005. Masters Thesis, Virginia Tech. Accessed March 08, 2021. http://hdl.handle.net/10919/31788.

MLA Handbook (7^th Edition):

Sennello, Kathleen Ann. “Comparison of the Effects of Deracoxib, Buffered Aspirin, and Placebo on the Gastric Mucosa of Healthy Dogs.” 2005. Web. 08 Mar 2021.

Vancouver:

Sennello KA. Comparison of the Effects of Deracoxib, Buffered Aspirin, and Placebo on the Gastric Mucosa of Healthy Dogs. [Internet] [Masters thesis]. Virginia Tech; 2005. [cited 2021 Mar 08]. Available from: http://hdl.handle.net/10919/31788.

Council of Science Editors:

Sennello KA. Comparison of the Effects of Deracoxib, Buffered Aspirin, and Placebo on the Gastric Mucosa of Healthy Dogs. [Masters Thesis]. Virginia Tech; 2005. Available from: http://hdl.handle.net/10919/31788

Virginia Tech

7. Reimer, Michele E. The Gastroduodenal Effects of Buffered Aspirin, Carprofen, And Etodolac in the Healthy Dog and Comparison of the CLOtest® to Histopathologic Evaluation in Identifying the Presence of Helicobacter Spp. in Healthy Dogs.

Degree: MS, Veterinary Medical Sciences, 1999, Virginia Tech

URL: http://hdl.handle.net/10919/33049

► Twenty-four healthy, mixed breed dogs were divided into four groups. Group I received a placebo PO BID, group II received an average 16.5 (range, 15.1-17.8)… (more)

▼ Twenty-four healthy, mixed breed dogs were divided into four groups. Group I received a placebo PO BID, group II received an average 16.5 (range, 15.1-17.8) mg/kg buffered aspirin PO BID, group III received an average 2.2 (range, 2.0-2.4) mg/kg carprofen PO BID, and group IV received an average 12.8 (range, 11.7-13.8) mg/kg etodolac PO QD (with a placebo in the P.M.). All treatments continued for 28 consecutive days. Gastroduodenal endoscopy was performed on days – 9, 0, 5, 14 and 28. Multiple gastric biopsies were obtained endoscopically on day – 9 to determine each dog's Helicobacter spp. status. Five areas, consisting of four regions in the stomach and one in the proximal duodenum, were evaluated endoscopically, and each was assigned a score from 1 to 11 based on qualitative assessment of submucosal hemorrhage, erosion, or ulceration. These scores for each region were then summed to give a total score for each endoscopic evaluation. Erosions and submucosal hemorrhages were seen in all dogs receiving aspirin. Only minor gastric lesions were observed in the carprofen, etodolac, and control groups. No adverse clinical signs were noted in any dog given any treatment during the course of the study. There was no predilection site for lesion development in any group. Median total score on days 0, 5, 14, and 28 were as follows: group I, 5.0, 5.0, 5.0, 5.0; group II, 5.0, 27.0, 26.0, 27.5; group III, 5.0, 5.0, 6.0, 5.0; group IV, 5.0, 7.0, 5.0, 5.0, respectively. There was no significant difference between dogs receiving carprofen, etodolac, or placebo. The administration of carprofen, etodolac, or placebo to healthy dogs resulted in significantly less gastroduodenal lesion development than in dogs receiving buffered aspirin. Thirty healthy, random source, dogs were evaluated to determine the prevalence of Helicobacter spp., and to compare the ‘Campylobacter-like organism’ test (CLOtest®) to histopathologic identification of Helicobacter spp. organisms. Gastric mucosal biopsies from each of four gastric regions (cardia, pyloric antrum, greater curvature, and angularis incisura) were obtained endoscopically for use in the CLOtest® and for histopathologic evaluation. Twenty-seven of 30 dogs (90%) were positive for spiral bacteria suspected to be Helicobacter spp. by histopathologic evaluation in at least one of the four gastric regions. Three dogs (10%) were negative for Helicobacter spp. in all gastric regions by histopathologic evaluation. The CLOtest® was found to have a sensitivity, specificity, and positive predictive value of 84%, 81%, and 92%, respectively, when compared to histopathologic evaluation. When only the angularis incisura was evaluated, the sensitivity, specificity, and positive predictive value increased to 92%, 94%, and 96%, respectively. The angularis incisura had the highest, whereas the pyloric antrum had the lowest, prevalence of positive test results when compared to dogs determined to be overall Helicobacter spp. positive (histopathologic positive in at least one gastric region). The… Advisors/Committee Members: Johnston, Spencer A. (committeechair), Pfeiffer, Carl J. (committee member), Leib, Michael S. (committee member), Duncan, Robert B. Jr. (committee member).

Subjects/Keywords: Non-steroidal Anti-inflammatory drugs; Endoscopy; Gastric Ulceration; Carprofen; Helicobacter; Canine; Etodolac

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Reimer, M. E. (1999). The Gastroduodenal Effects of Buffered Aspirin, Carprofen, And Etodolac in the Healthy Dog and Comparison of the CLOtest® to Histopathologic Evaluation in Identifying the Presence of Helicobacter Spp. in Healthy Dogs. (Masters Thesis). Virginia Tech. Retrieved from http://hdl.handle.net/10919/33049

Chicago Manual of Style (16^th Edition):

Reimer, Michele E. “The Gastroduodenal Effects of Buffered Aspirin, Carprofen, And Etodolac in the Healthy Dog and Comparison of the CLOtest® to Histopathologic Evaluation in Identifying the Presence of Helicobacter Spp. in Healthy Dogs.” 1999. Masters Thesis, Virginia Tech. Accessed March 08, 2021. http://hdl.handle.net/10919/33049.

MLA Handbook (7^th Edition):

Reimer, Michele E. “The Gastroduodenal Effects of Buffered Aspirin, Carprofen, And Etodolac in the Healthy Dog and Comparison of the CLOtest® to Histopathologic Evaluation in Identifying the Presence of Helicobacter Spp. in Healthy Dogs.” 1999. Web. 08 Mar 2021.

Vancouver:

Reimer ME. The Gastroduodenal Effects of Buffered Aspirin, Carprofen, And Etodolac in the Healthy Dog and Comparison of the CLOtest® to Histopathologic Evaluation in Identifying the Presence of Helicobacter Spp. in Healthy Dogs. [Internet] [Masters thesis]. Virginia Tech; 1999. [cited 2021 Mar 08]. Available from: http://hdl.handle.net/10919/33049.

Council of Science Editors:

Reimer ME. The Gastroduodenal Effects of Buffered Aspirin, Carprofen, And Etodolac in the Healthy Dog and Comparison of the CLOtest® to Histopathologic Evaluation in Identifying the Presence of Helicobacter Spp. in Healthy Dogs. [Masters Thesis]. Virginia Tech; 1999. Available from: http://hdl.handle.net/10919/33049

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